Reference on EC 3.4.23.B24 - signal peptide peptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schrul, B.; Kapp, K.; Sinning, I.; Dobberstein, B.
Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes
Biochem. J.
427
523-534
2010
Homo sapiens
Gertsik, N.; Chau, D.M.; Li, Y.M.
gamma-Secretase inhibitors and modulators induce distinct conformational changes in the active sites of gamma-secretase and signal peptide peptidase
ACS Chem. Biol.
10
1925-1931
2015
Homo sapiens
Baldwin, M.; Russo, C.; Li, X.; Chishti, A.H.
Plasmodium falciparum signal peptide peptidase cleaves malaria heat shock protein 101 (HSP101). Implications for gametocytogenesis
Biochem. Biophys. Res. Commun.
450
1427-1432
2014
Plasmodium falciparum (C0KWU7), Plasmodium falciparum
Nam, S.E.; Paetzel, M.
Structure of signal peptide peptidase A with C-termini bound in the active sites: insights into specificity, self-processing, and regulation
Biochemistry
52
8811-8822
2013
Bacillus subtilis (O34525), Bacillus subtilis, Bacillus subtilis 168 (O34525)
Hoshi, M.; Ohki, Y.; Ito, K.; Tomita, T.; Iwatsubo, T.; Ishimaru, Y.; Abe, K.; Asakura, T.
Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana
BMC Biochem.
14
16
2013
Arabidopsis thaliana (O81062), Arabidopsis thaliana
Chen, C.Y.; Malchus, N.S.; Hehn, B.; Stelzer, W.; Avci, D.; Langosch, D.; Lemberg, M.K.
Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u
EMBO J.
33
2492-2506
2014
Homo sapiens
Nam, S.E.; Kim, A.C.; Paetzel, M.
Crystal structure of Bacillus subtilis signal peptide peptidase A
J. Mol. Biol.
419
347-358
2012
Bacillus subtilis (O34525), Bacillus subtilis, Bacillus subtilis 168 (O34525)
Hsu, F.F.; Yeh, C.T.; Sun, Y.J.; Chiang, M.T.; Lan, W.M.; Li, F.A.; Lee, W.H.; Chau, L.Y.
Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity
Oncogene
34
2360-2370
2015
Homo sapiens
Moss, C.X.; Brown, E.; Hamilton, A.; Van der Veken, P.; Augustyns, K.; Mottram, J.C.
An essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma brucei
PLoS ONE
10
e0123241
2015
Trypanosoma brucei
Allen, S.J.; Mott, K.R.; Matsuura, Y.; Moriishi, K.; Kousoulas, K.G.; Ghiasi, H.
Binding of HSV-1 glycoprotein K (gK) to signal peptide peptidase (SPP) is required for virus infectivity
PLoS ONE
9
e85360
2014
Homo sapiens
Mentrup, T.; Loock, A.C.; Fluhrer, R.; Schroeder, B.
Signal peptide peptidase and SPP-like proteases - possible therapeutic targets?
Biochim. Biophys. Acta
1864
2169-2182
2017
Mus musculus (Q3TD49), Mus musculus (Q9CUS9), Mus musculus (Q9D8V0), Mus musculus (Q9JJF9), Plasmodium falciparum (Q8IKQ9), Homo sapiens (Q8IUH8)
Yuecel, S.S.; Stelzer, W.; Lorenzoni, A.; Wozny, M.; Langosch, D.; Lemberg, M.K.
The metastable XBP1u transmembrane domain defines determinants for intramembrane proteolysis by signal peptide peptidase
Cell Rep.
26
3087-3099.e11
2019
Homo sapiens
Papadopoulou, A.A.; Mueller, S.A.; Mentrup, T.; Shmueli, M.D.; Niemeyer, J.; Haug-Kroeper, M.; von Blume, J.; Mayerhofer, A.; Feederle, R.; Schroeder, B.; Lichtenthaler, S.F.; Fluhrer, R.
Signal peptide peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins
EMBO Rep.
20
e46451
2019
Mus musculus (A2A6C4)
Papadopoulou, A.A.; Mueller, S.A.; Mentrup, T.; Shmueli, M.D.; Niemeyer, J.; Haug-Kroeper, M.; von Blume, J.; Mayerhofer, A.; Feederle, R.; Schroeder, B.; Lichtenthaler, S.F.; Fluhrer, R.
Signal peptide peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins
EMBO Rep.
20
e46451
2019
Mus musculus (A2A6C4), Homo sapiens (Q8IUH8)
Velcicky, J.; Bodendorf, U.; Rigollier, P.; Epple, R.; Beisner, D.R.; Guerini, D.; Smith, P.; Liu, B.; Feifel, R.; Wipfli, P.; Aichholz, R.; Couttet, P.; Dix, I.; Widmer, T.; Wen, B.; Brandl, T.
Discovery of the first potent, selective, and orally bioavailable signal peptide peptidase-like 2a (SPPL2a) inhibitor displaying pronounced immunomodulatory effects in vivo
J. Med. Chem.
61
865-880
2018
Rattus norvegicus (D3ZNG3), Homo sapiens (Q8TCT8), Mus musculus (Q9JJF9), Mus musculus
Cai, D.; Wang, H.; He, P.; Zhu, C.; Wang, Q.; Wei, X.; Nomura, C.T.; Chen, S.
A novel strategy to improve protein secretion via overexpression of the SppA signal peptide peptidase in Bacillus licheniformis
Microb. Cell Fact.
16
70
2017
Bacillus licheniformis, Bacillus licheniformis BL10
Bat-Ochir, C.; Kwak, J.Y.; Koh, S.K.; Jeon, M.H.; Chung, D.; Lee, Y.W.; Chae, S.K.
The signal peptide peptidase SppA is involved in sterol regulatory element-binding protein cleavage and hypoxia adaptation in Aspergillus nidulans
Mol. Microbiol.
100
635-655
2016
Aspergillus nidulans, Aspergillus nidulans A773
Hsu, F.F.; Chou, Y.T.; Chiang, M.T.; Li, F.A.; Yeh, C.T.; Lee, W.H.; Chau, L.Y.
Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation
Oncogene
38
1688-1701
2019
Homo sapiens
Ran, Y.; Ladd, G.Z.; Ceballos-Diaz, C.; Jung, J.I.; Greenbaum, D.; Felsenstein, K.M.; Golde, T.E.
Differential inhibition of signal peptide peptidase family members by established gamma-secretase inhibitors
PLoS ONE
10
e0128619
2015
Homo sapiens, Mus musculus, Plasmodium sp.
Schaefer, B.; Moriishi, K.; Behrends, S.
Insights into the mechanism of isoenzyme-specific signal peptide peptidase-mediated translocation of heme oxygenase
PLoS ONE
12
e0188344
2017
Homo sapiens
Plegge, T.; Spiegel, M.; Krueger, N.; Nehlmeier, I.; Winkler, M.; Gonzalez Hernandez, M.; Poehlmann, S.
Inhibitors of signal peptide peptidase and subtilisin/kexin-isozyme 1 inhibit Ebola virus glycoprotein-driven cell entry by interfering with activity and cellular localization of endosomal cathepsins
PLoS ONE
14
e0214968
2019
Homo sapiens
Pinter, N.; Hach, C.A.; Hampel, M.; Rekhter, D.; Zienkiewicz, K.; Feussner, I.; Poehlein, A.; Daniel, R.; Finkernagel, F.; Heimel, K.
Signal peptide peptidase activity connects the unfolded protein response to plant defense suppression by Ustilago maydis
PLoS Pathog.
15
e1007734
2019
Ustilago maydis (A0A0D1E4M7), Ustilago maydis, Ustilago maydis 521 (A0A0D1E4M7), Ustilago maydis FGSC 9021 (A0A0D1E4M7)
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