Information on EC 3.4.23.B18 - mouse mammary tumor virus retropepsin

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The expected taxonomic range for this enzyme is: Mouse mammary tumor virus

EC NUMBER
COMMENTARY hide
3.4.23.B18
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
mouse mammary tumor virus retropepsin
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Processing of viral polyprotein. Selective for large aromatic residues (Tyr and Phe) at position P1. Phe and Leu are preferred at position P3. No hydrolysis of substrates with Gly or Ala at position P3. Medium-sized or large hydrophobic residues as Ile, Leu and Phe are preferred at position P4.
show the reaction diagram
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-
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
VFQNYPIVQ + H2O
VFQNY + PIVQ
show the reaction diagram
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medium-sized or large hydrophobic residues as Ile, Leu and Phe are preferred at position P4
-
-
?
VIQNYPIVQ + H2O
VIQNY + PIVQ
show the reaction diagram
-
medium-sized or large hydrophobic residues as Ile, Leu and Phe are preferred at position P4
-
-
?
VLQNYPIVQ + H2O
VLQNY + PIVQ
show the reaction diagram
-
medium-sized or large hydrophobic residues as Ile, Leu and Phe are preferred at position P4
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-
?
VSFNYPIVQ + H2O
VSFNY + PIVQ
show the reaction diagram
-
Phe and Leu are preferred at position P3. No hydrolysis of substrates with Gly or Ala at position P3
-
-
?
VSLNYPIVQ + H2O
VSLNY + PIVQ
show the reaction diagram
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Phe and Leu are preferred at position P3. No hydrolysis of substrates with Gly or Ala at position P3
-
-
?
VSQCYPIVG + H2O
VSQCY + PIVG
show the reaction diagram
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peptides with an Ile at position P2 are the best substrate, lower activity with Cys or Leu at position P2
-
-
?
VSQIYPIVG + H2O
VSQIY + PIVG
show the reaction diagram
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peptides with an Ile at position P2 are the best substrate, lower activity with Cys or Leu at position P2
-
-
?
VSQLYPIVG + H2O
VSQLY + PIVG
show the reaction diagram
-
peptides with an Ile at position P2 are the best substrate, lower activity with Cys or Leu at position P2
-
-
?
VSQNFPIVQ + H2O
VSQNF + PIVQ
show the reaction diagram
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selective for large aromatic residues (Tyr and Phe) at position P1
-
-
?
VSQNYPIVQ + H2O
VSQNY + PIVQ
show the reaction diagram
-
selective for large aromatic residues (Tyr and Phe) at position P1
-
-
?