Reference on EC 3.4.23.45 - memapsin 1
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Farzan, M.; Schnitzler, C.E.; Vasilieva, N.; Leung, D.; Choe, H.
BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein
Proc. Natl. Acad. Sci. USA
97
9712-9717
2000
Homo sapiens
Fluhrer, R.; Capell, A.; Westmeyer, G.; Willem, M.; Hartung, B.; Condron, M.M.; Teplow, D.B.; Haass, C.; Walter, J.
A non-amyloidogenic function of BACE-2 in the secretory pathway
J. Neurochem.
81
1011-1020
2002
Homo sapiens
Ghosh, A.K.; Bilcer, G.; Harwood, C.; Kawahama, R.; Shin, D.; Hussain, K.A.; Hong, L.; Loy, J.A.; Nguyen, C.; Koelsch, G.; Ermolieff, J.; Tang, J.
Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase)
J. Med. Chem.
44
2865-2868
2001
Homo sapiens
Kim, Y.T.; Downs, D.; Wu, S.; Dashti, A.; Pan, Y.; Zhai, P.; Wang, X.; Zhang, X.C.; Lin, X.
Enzymic properties of recombinant BACE2
Eur. J. Biochem.
269
5668-5677
2002
Homo sapiens
Li, G.; Percontino, L.; Sun, Q.; Qazi, A.S.; Frederikse, P.H.
beta-Amyloid secretases and beta-amyloid degrading enzyme expression in lens
Mol. Vis.
9
179-183
2003
Mus musculus, Rattus norvegicus, Mus musculus C57B16/J
Motonaga, K.; Itoh, M.; Becker, L.E.; Goto, Y.I.; Takashima, S.
Elevated expression of beta-site amyloid precursor protein cleaving enzyme 2 in brains of patients with Down syndrome
Neurosci. Lett.
326
64-66
2002
Homo sapiens
Solans, A.; Estivill, X.; de La Luna, S.
A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase
Cytogenet. Cell Genet.
89
177-184
2000
Homo sapiens, Homo sapiens (Q9Y5Z0)
Turner, R.T.3rd.; Loy, J.A.; Nguyen, C.; Devasamudram, T.; Ghosh, A.K.; Koelsch, G.; Tang, J.
Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity
Biochemistry
41
8742-8746
2002
Homo sapiens
Vattemi, G.; Engel, W.K.; McFerrin, J.; Pastorino, L.; Buxbaum, J.D.; Askanas, V.
BACE1 and BACE2 in pathologic and normal human muscle
Exp. Neurol.
179
150-158
2003
Homo sapiens
Hussain, I.; Powell, D.J.; Howlett, D.R.; Chapman, G.A.; Gilmour, L.; Murdock, P.R.; Tew, D.G.; Meek, T.D.; Chapman, C.; Schneider, K.; Ratcliffe, S.J.; Tattersall, D.; Testa, T.T.; Southan, C.; Ryan, D.M.; Simmons, D.L.; Walsh, F.S.; Dingwall, C.; Christie, G.
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site
Mol. Cell. Neurosci.
16
609-619
2000
Homo sapiens (Q9Y5Z0)
Tang, J.; Koelsch, G.
Memapsin 1
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )
1
64-66
2004
Homo sapiens
-
Ostermann, N.; Eder, J.; Eidhoff, U.; Zink, F.; Hassiepen, U.; Worpenberg, S.; Maibaum, J.; Simic, O.; Hommel, U.; Gerhartz, B.
Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor
J. Mol. Biol.
355
249-261
2006
Homo sapiens
Lahiri, D.K.; Maloney, B.; Ge, Y.W.
Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells
J. Mol. Neurosci.
29
65-80
2006
Homo sapiens
Maloney, B.; Ge, Y.W.; Greig, N.H.; Lahiri, D.K.
Characterization of the human beta-secretase 2 (BACE2) 5-flanking region: identification of a 268-bp region as the basal BACE2 promoter
J. Mol. Neurosci.
29
81-99
2006
Homo sapiens
Chou, K.C.
Insights from modeling the tertiary structure of human BACE2
J. Proteome Res.
3
1069-1072
2004
Homo sapiens (Q9Y5Z0), Homo sapiens
Stockley, J.H.; O'Neill, C.
The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimers disease brain
Biochem. Soc. Trans.
35
574-576
2007
Homo sapiens
Stockley, J.H.; Ravid, R.; ONeill, C.
Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimers disease brain
FEBS Lett.
580
6550-6560
2006
Homo sapiens, Rattus norvegicus
Cheon, M.S.; Dierssen, M.; Kim, S.H.; Lubec, G.
Protein expression of BACE1, BACE2 and APP in Down syndrome brains
Amino Acids
35
339-343
2007
Homo sapiens
Sun, X.; He, G.; Song, W.
BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimers disease in Down syndrome
FASEB J.
20
1369-1376
2006
Homo sapiens
Kuhn, P.H.; Marjaux, E.; Imhof, A.; De Strooper, B.; Haass, C.; Lichtenthaler, S.F.
Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase
J. Biol. Chem.
282
11982-11995
2007
Homo sapiens
Venugopal, C.; Demos, C.M.; Rao, K.S.; Pappolla, M.A.; Sambamurti, K.
beta-Secretase: structure, function, and evolution
CNS Neurol. Disord. Drug Targets
7
278-294
2008
Homo sapiens
Castorina, A.; Tiralongo, A.; Giunta, S.; Carnazza, M.L.; Scapagnini, G.; DAgata, V.
Early effects of aluminum chloride on beta-secretase mRNA expression in a neuronal model of ss-amyloid toxicity
Cell Biol. Toxicol.
26
367-377
2010
Homo sapiens (Q9Y5Z0)
Ahmed, R.R.; Holler, C.J.; Webb, R.L.; Li, F.; Beckett, T.L.; Murphy, M.P.
BACE1 and BACE2 enzymatic activities in Alzheimers disease
J. Neurochem.
112
1045-1053
2010
Homo sapiens
Vassar, R.; Kovacs, D.M.; Yan, R.; Wong, P.C.
The beta-secretase enzyme BACE in health and Alzheimers disease: regulation, cell biology, function, and therapeutic potential
J. Neurosci.
29
12787-12794
2009
Homo sapiens
Casas, S.; Casini, P.; Piquer, S.; Altirriba, J.; Soty, M.; Cadavez, L.; Gomis, R.; Novials, A.
BACE2 plays a role in the insulin receptor trafficking in pancreatic beta-cells
Am. J. Physiol. Endocrinol. Metab.
299
E1087-E1095
2010
Homo sapiens
Esterhazy, D.; Stuetzer, I.; Wang, H.; Rechsteiner, M.P.; Beauchamp, J.; Doebeli, H.; Hilpert, H.; Matile, H.; Prummer, M.; Schmidt, A.; Lieske, N.; Boehm, B.; Marselli, L.; Bosco, D.; Kerr-Conte, J.; Aebersold, R.; Spinas, G.A.; Moch, H.; Migliorini, C.; Stoffel, M.
Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass
Cell Metab.
14
365-377
2011
Mus musculus
Azkona, G.; Amador-Arjona, A.; Obradors-Tarrago, C.; Varea, E.; Arque, G.; Pinacho, R.; Fillat, C.; De La Luna, S.; Estivill, X.; Dierssen, M.
Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2
Genes Brain Behav.
9
160-172
2010
Homo sapiens
Al-Tel, T.; Semreen, M.; Al-Qawasmeh, R.; Schmidt, M.; El-Awadi, R.; Ardah, M.; Zaarour, R.; Rao, S.; El-Agnaf, O.
Design, synthesis, and qualitative structure-activity evaluations of novel beta-secretase inhibitors as potential Alzheimers drug leads
J. Med. Chem.
54
8373-8385
2011
Homo sapiens
Holler, C.; Webb, R.; Laux, A.; Beckett, T.; Niedowicz, D.; Ahmed, R.; Liu, Y.; Simmons, C.; Dowling, A.; Spinelli, A.; Khurgel, M.; Estus, S.; Head, E.; Hersh, L.; Murphy, M.
BACE2 expression increases in human neurodegenerative disease
Am. J. Pathol.
180
337-350
2012
Homo sapiens (Q9Y5Z0), Homo sapiens
Stuetzer, I.; Selevsek, N.; Esterhazy, D.; Schmidt, A.; Aebersold, R.; Stoffel, M.
Systematic proteomic analysis identifies beta-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic beta-cells
J. Biol. Chem.
288
10536-10547
2013
Mus musculus (Q9JL18)
van Bebber, F.; Hruscha, A.; Willem, M.; Schmid, B.; Haass, C.
Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes
J. Neurochem.
127
471-481
2013
Danio rerio (X4Z0F5), Danio rerio
Abdul-Hay, S.O.; Sahara, T.; McBride, M.; Kang, D.; Leissring, M.A.
Identification of BACE2 as an avid beta-amyloid-degrading protease
Mol. Neurodegener.
7
46
2012
Homo sapiens (Q9Y5Z0)
Rochin, L.; Hurbain, I.; Serneels, L.; Fort, C.; Watt, B.; Leblanc, P.; Marks, M.S.; De Strooper, B.; Raposo, G.; van Niel, G.
BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells
Proc. Natl. Acad. Sci. USA
110
10658-10663
2013
Mus musculus (Q9JL18)
Mirsafian, H.; Mat Ripen, A.; Merican, A.F.; Bin Mohamad, S.
Amino acid sequence and structural comparison of BACE1 and BACE2 using evolutionary trace method
ScientificWorldJournal
2014
482463
2014
Homo sapiens (Q9Y5Z0)
Ghosh, A.K.; Reddy, B.S.; Yen, Y.C.; Cardenas, E.; Rao, K.V.; Downs, D.; Huang, X.; Tang, J.; Mesecar, A.D.
Design of potent and highly selective inhibitors for human beta-secretase 2 (memapsin 1), a target for type 2 diabetes
Chem. Sci.
7
3117-3122
2016
Homo sapiens (Q9Y5Z0), Homo sapiens
Ghosh, A.K.; Brindisi, M.; Yen, Y.C.; Lendy, E.K.; Kovela, S.; Cardenas, E.L.; Reddy, B.S.; Rao, K.V.; Downs, D.; Huang, X.; Tang, J.; Mesecar, A.D.
Highly selective and potent human beta-secretase 2 (BACE2) inhibitors against type 2 diabetes design, synthesis, X-ray structure and structure-activity relationship studies
ChemMedChem
14
545-560
2019
Homo sapiens (Q9Y5Z0), Homo sapiens
Fujimoto, K.; Matsuoka, E.; Asada, N.; Tadano, G.; Yamamoto, T.; Nakahara, K.; Fuchino, K.; Ito, H.; Kanegawa, N.; Moechars, D.; Gijsen, H.J.M.; Kusakabe, K.I.
Structure-based design of selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors targeting the flap to gain selectivity over BACE2
J. Med. Chem.
62
5080-5095
2019
Homo sapiens (Q9Y5Z0)
Kumalo, H.M.; Soliman, M.E.
A comparative molecular dynamics study on BACE1 and BACE2 flap flexibility
J. Recept. Signal Transduct. Res.
36
505-514
2016
Homo sapiens (Q9Y5Z0)
Wang, Z.; Xu, Q.; Cai, F.; Liu, X.; Wu, Y.; Song, W.
BACE2, a conditional beta-secretase, contributes to Alzheimer's disease pathogenesis
JCI Insight
4
e123431
2019
Mus musculus (Q9JL18), Mus musculus
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