Information on EC 3.4.22.B8 - Tpr proteinase (Porphyromonas gingivalis)

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The expected taxonomic range for this enzyme is: Porphyromonas gingivalis

EC NUMBER
COMMENTARY hide
3.4.22.B8
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
Tpr proteinase (Porphyromonas gingivalis)
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
37353-41-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Azocoll + H2O
?
show the reaction diagram
Bovine serum albumin + H2O
?
show the reaction diagram
casein + H2O
?
show the reaction diagram
denatured collagen + H2O
?
show the reaction diagram
no activity on native collagen
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ca2+
inhibitory concentration: 15-20 mM
Co2+
inhibitory below 5 mM
Cu2+
inhibitory below 5 mM
Fe2+
inhibitory below 5 mM
Hg2+
inhibitory below 5 mM
Mg2+
inhibitory concentration: 15-20 mM
Mn2+
inhibitory concentration: 5-10 mM
Ni2+
inhibitory below 5 mM
Zn2+
inhibitory below 5 mM
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
stimulates
cysteine
stimulates
dithiothreitol
stimulates
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
inactive at or below 20 C when azocoll is the substrate, inactive at 90 C
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
55000
-
2 * 55000
64000
x * 64000, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
2 * 55000
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
controll of trp expression in Escherichia coli appears to be quite different from expression in Porphyra gingivalis
-
expression in Escherichia coli