Information on EC 3.4.22.B76 - Allium alpha-fibrinogenase AFTEII

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The expected taxonomic range for this enzyme is: Allium tuberosum

EC NUMBER
COMMENTARY hide
3.4.22.B76
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
Allium alpha-fibrinogenase AFTEII
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
the enzyme degrades the Aalpha-chain of human fibrinogen but not the Bbeta-chain
show the reaction diagram
-
-
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Human fibrinogen + H2O
?
show the reaction diagram
-
cleavage of the Aalpha-chain, but not of the Bbeta-chain or the gamma-chain by AFTEII
-
-
?
MeO-Suc-Arg-Pro-Tyr-4-nitroanilide + H2O
?
show the reaction diagram
-
i.e. S-2586, ATFEII is highly specific for the chromogenic chymotrypsin substrate
-
-
?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
leupeptin
-
complete inhibition of AFTEII at 1 mM
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45
-
AFTEII
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45000
-
x * 45000, AFTEII, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 45000, AFTEII, SDS-PAGE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
-
AFTEII may be useful as thrombolytic agent