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Information on EC 3.4.22.B6 - cathepsin B-like protease

for references in articles please use BRENDA:EC3.4.22.B6
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B6 cathepsin B-like protease
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This record set is specific for:
UNIPROT: Q25030
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
the enzyme does not readily hyrolyze benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin (which is cleaved by cathespsin B). The enzyme is not able to cleave synthetic substrates having an Arg in position P2
Synonyms
tbcatb, catb2, cathepsin b-like cysteine proteinase, cmcatb, cathepsin b-like protease, tcocbc1, eimeripain, cathb3, trcb2, tcocbc6, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
AC-5 cathepsin B-like protease
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cathepsin B-like cysteine protease
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-
-
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CPB
-
-
-
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CPC protease
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-
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LmacatB
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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-
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CAS REGISTRY NUMBER
COMMENTARY hide
37353-41-6
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cystatin
Haemonchus contortus, GenBank accession number AF035945
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L-transepoxysuccinyl-L-leucylamido-(4-guanidino)-butane
E64
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q25030_HAECO
348
0
38826
TrEMBL
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
43000
x * 43000, SDS-PAGE, predicted: 36700 Da (with pro-region and without signal peptide), 29000 Da (without pro-region)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 43000, SDS-PAGE, predicted: 36700 Da (with pro-region and without signal peptide), 29000 Da (without pro-region)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
cystatin affinity chromatography
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
De Vries, E.; Bakker, N.; Krijgsveld, J.; Knox, D.P.; Heck, A.J.; Yatsuda, A.P.
An AC-5 cathepsin B-like protease purified from Haemonchus contortus excretory secretory products shows protective antigen potential for lambs
Vet. Res.
40
41
2009
Haemonchus contortus (Q25030), Haemonchus contortus
Manually annotated by BRENDA team