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EC Tree
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
broad endopeptidase specificity
Synonyms
capn12, calpain 12,
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Capn12
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peptide + H2O
hydrolyzed peptide
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Ca2+
calcium-regulated thiol protease
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SwissProt
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physiological function
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RNA knockdown of calpain 12 in skin from K14-H2B GFP mice leads to significant hair follicle catagen transformation compared with controls
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CAN12_MOUSE
720
0
80588
Swiss-Prot
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Mus musculus (Q9ER56)
brenda
Strausberg R.L.; Feingold E.A.; Grouse L.H.; Derge J.G.; et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Proc. Natl. Acad. Sci. USA
99
16899-16903
2002
Mus musculus (Q9ER56)
brenda
Dear, T.N.; meier, N.T.; Hunn, M.; Boehm, T.
Gene structure, chromosomal localization and expression pattern of Capn12, a new member of the calpain large subunit gene family
Genomics
68
152-160
2000
Mus musculus (Q9ER56), Mus musculus
brenda
Bochner, R.; Samuelov, L.; Sarig, O.; Li, Q.; Adase, C.A.; Isakov, O.; Malchin, N.; Vodo, D.; Shayevitch, R.; Peled, A.; Yu, B.D.; Fainberg, G.; Warshauer, E.; Adir, N.; Erez, N.; Gat, A.; Gottlieb, Y.; Rogers, T.; Pavlovsky, M.; Goldberg, I.; Shomron, N.; Sandilands, A.; Campbell, L.E.; MacCallum, S.; M, M.c.
Calpain 12 function revealed through the study of an atypical case of autosomal recessive congenital ichthyosis
J. Invest. Dermatol.
137
385-393
2017
Danio rerio, Homo sapiens, Mus musculus
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