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Information on EC 3.4.22.B29 - calpain 9 and Organism(s) Rattus norvegicus and UniProt Accession O35920

for references in articles please use BRENDA:EC3.4.22.B29
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B29 calpain 9
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This record set is specific for:
Rattus norvegicus
UNIPROT: O35920
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The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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broad endopeptidase specificity
Synonyms
ncl-4, calpain 9, calpain-9, digestive tract-specific calpain, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
digestive tract-specific calpain
-
-
-
-
nCL-4
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
78990-62-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
peptide + H2O
hydrolyzed peptide
show the reaction diagram
-
-
-
?
additional information
?
-
specialized functions of nCL-4 in the digestive tract
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
specialized functions of nCL-4 in the digestive tract
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
calpastatin
-
-
NaCl
4% down-regulates the enzyme by more than 50% in the kidney and heart but not in the aorta
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
predominantly expressed in
Manually annotated by BRENDA team
predominantly expressed in
Manually annotated by BRENDA team
additional information
no expression in the uterus
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CAN9_RAT
690
0
79263
Swiss-Prot
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
overexpression in COS-7 cells
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
differential regulation of calpain 9 plays a role in hypertensive target organ damage
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (O14815), Mus musculus (Q9D805), Mus musculus C57/BL6J (Q9D805), Rattus norvegicus (O35920)
Manually annotated by BRENDA team
Lee, H.J.; Sorimachi, H.; Jeong, S.Y.; Ishiura, S.; Suzuki, K.
Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract
Biol. Chem.
379
175-183
1998
Homo sapiens (O14815), Homo sapiens, Mus musculus (Q9D805), Mus musculus, Rattus norvegicus (O35920)
Manually annotated by BRENDA team
Markmann, A.; Schaefer, S.; Linz, W.; Loehn, M.; Busch, A.E.; Wohlfart, P.
Down-regulation of calpain 9 is linked to hypertensive heart and kidney disease
Cell. Physiol. Biochem.
15
109-116
2005
Rattus norvegicus (O35920)
Manually annotated by BRENDA team