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Information on EC 3.4.22.B24 - calpain 4

for references in articles please use BRENDA:EC3.4.22.B24
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B24 calpain 4
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This record set is specific for:
UNIPROT: P04632
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
broad endopeptidase specificity
Synonyms
capn4, calpain small subunit 1, calpain 4, css-1, calpain regulatory subunit, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
calcium-activated neutral proteinase
-
-
-
-
calpain regulatory subunit
-
-
-
-
CANP
-
-
-
-
Capn4
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
78990-62-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
peptide + H2O
hydrolyzed peptide
show the reaction diagram
-
-
-
?
additional information
?
-
limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
translocates to the plasma membrane upon Ca2+ binding
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CPNS1_HUMAN
268
0
28316
Swiss-Prot
other Location (Reliability: 1)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
heterodimer of a large and a small subunit
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Bos taurus (P13135), Homo sapiens (P04632), Mus musculus (O88456), Rattus norvegicus (Q64537), Sus scrofa (P04574)
Manually annotated by BRENDA team
Strobl S.; Fernandez-Catalan C.; Braun M.; Huber R.; Masumoto H.; Nakagawa K.; Irie A.; Sorimachi H.; Bourenkow G.; Bartunik H.; Suzuki K.; Bode W.
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium
Proc. Natl. Acad. Sci. USA
97
588-592
2000
Homo sapiens (P04632)
Manually annotated by BRENDA team
Strausberg R.L.; Feingold E.A.; Grouse L.H.; Derge J.G.; et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Proc. Natl. Acad. Sci. USA
99
16899-16903
2002
Homo sapiens (P04632), Mus musculus (O88456)
Manually annotated by BRENDA team
Ohno, S.; Emori, Y.; Suzuki, K.
Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease
Nucleic Acids Res.
14
5559-5559
1986
Homo sapiens (P04632)
Manually annotated by BRENDA team
Miyake S.; Emori Y.; Suzuki K.
Gene organization of the small subunit of human calcium-activated neutral protease
Nucleic Acids Res.
14
8805-8817
1986
Homo sapiens (P04632)
Manually annotated by BRENDA team