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Adenocarcinoma
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9.
Altitude Sickness
Genetic variation in SENP1 and ANP32D as predictors of chronic mountain sickness.
Altitude Sickness
SENP1, but not fetal hemoglobin, differentiates Andean highlanders with chronic mountain sickness from healthy individuals among Andean highlanders.
Anemia
SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis.
Anemia
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia.
Arthritis, Rheumatoid
Epigenetics and rheumatoid arthritis: The role of SENP1 in the regulation of MMP-1 expression.
Astrocytoma
Inhibition of SUMO-specific protease 1 induces apoptosis of astroglioma cells by regulating NF-?B/Akt pathways.
Ataxia Telangiectasia
NF-?B Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress.
Atherosclerosis
Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function.
Atherosclerosis
Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior.
Atherosclerosis
SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation.
Autoimmune Diseases
Epigenetics and rheumatoid arthritis: The role of SENP1 in the regulation of MMP-1 expression.
Brain Ischemia
Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis.
Brain Ischemia
Role of pericyte-derived SENP1 in neuronal injury after brain ischemia.
Breast Neoplasms
A SUMOylation-dependent HIF-1?/CLDN6 negative feedback mitigates hypoxia-induced breast cancer metastasis.
Breast Neoplasms
Association of SENPs single-nucleotide polymorphism and breast cancer in Chinese population.
Breast Neoplasms
Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition.
Breast Neoplasms
Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer.
Breast Neoplasms
Regulation of post-translational modification in breast cancer treatment.
Breast Neoplasms
SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function.
Breast Neoplasms
SENP2 suppresses NF-?B activation and sensitizes breast cancer cells to doxorubicin.
Breast Neoplasms
SUMO Losing Balance: SUMO Proteases Disrupt SUMO Homeostasis to Facilitate Cancer Development and Progression.
Breast Neoplasms
SUMO protease SENP1 deSUMOylates and stabilizes c-Myc.
Breast Neoplasms
Transcriptional repression of estrogen receptor ? signaling by SENP2 in breast cancer cells.
Burkitt Lymphoma
Down-regulation of SENP1 Expression Increases Apoptosis of Burkitt Lymphoma Cells.
Carcinogenesis
Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers.
Carcinogenesis
Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression.
Carcinogenesis
Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort.
Carcinogenesis
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells.
Carcinogenesis
SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T.
Carcinogenesis
SENP1 regulates PTEN stability to dictate prostate cancer development.
Carcinogenesis
SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function.
Carcinogenesis
The Epstein-Barr Virus Oncoprotein, LMP1, Regulates the Function of SENP2, a SUMO-protease.
Carcinogenesis
The in vivo functions of desumoylating enzymes.
Carcinogenesis
The SUMO-specific protease SENP5 controls DNA damage response and promotes tumorigenesis in hepatocellular carcinoma.
Carcinogenesis
Tumor-suppressive microRNA-145 induces growth arrest by targeting SENP1 in human prostate cancer cells.
Carcinogenesis
[A verification study on the genes associated with laryngeal squamous cell carcinoma by cDNA microarray]
Carcinogenesis
[SUMO-specific protease 1 and cancer]
Carcinoma
Coamplification and Cooperation: Toward Identifying Biologically Relevant Oncogenes.
Carcinoma
Inhibition of SENP1 induces radiosensitization in lung cancer cells.
Carcinoma
SENP1 Interacts with HIF1? to Regulate Glycolysis of Prostatic Carcinoma Cells.
Carcinoma
SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis.
Carcinoma
SENP1 regulates PTEN stability to dictate prostate cancer development.
Carcinoma
The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment.
Carcinoma, Hepatocellular
Inhibition of SENP6-Induced Radiosensitization of Human Hepatocellular Carcinoma Cells by Blocking Radiation-Induced NF-?B Activation.
Carcinoma, Hepatocellular
SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T.
Carcinoma, Hepatocellular
SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma.
Carcinoma, Hepatocellular
SENP2 regulated the stability of ?-catenin through WWOX in hepatocellular carcinoma cell.
Carcinoma, Hepatocellular
SENP2 regulates hepatocellular carcinoma cell growth by modulating the stability of ?-catenin.
Carcinoma, Hepatocellular
The SUMO-specific protease SENP5 controls DNA damage response and promotes tumorigenesis in hepatocellular carcinoma.
Carcinoma, Ovarian Epithelial
Upregulation of SENP3/SMT3IP1 promotes epithelial ovarian cancer progression and forecasts poor prognosis.
Carcinoma, Renal Cell
SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis.
Carcinoma, Squamous Cell
Coamplification and Cooperation: Toward Identifying Biologically Relevant Oncogenes.
Cardiomegaly
Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy.
Cardiomyopathies
Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy.
Cardiovascular Diseases
Identification of novel anti-cancer agents, applying in silico method for SENP1 protease inhibition.
Cardiovascular Diseases
SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1.
Cataract
Molecular signature for senile and complicated cataracts derived from analysis of sumoylation enzymes and their substrates in human cataract lenses.
Colonic Neoplasms
Identification of SENP1 inhibitors through in silico screening and rational drug design.
Colonic Neoplasms
Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway.
Colonic Neoplasms
SENP1 participates in Irinotecan resistance in human colon cancer cells.
Colonic Neoplasms
SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors.
Colorectal Neoplasms
MiR-133a-3p Targets SUMO-Specific Protease 1 to Inhibit Cell Proliferation and Cell Cycle Progress in Colorectal Cancer.
Colorectal Neoplasms
SENP1 participates in Irinotecan resistance in human colon cancer cells.
Congenital Abnormalities
The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.
Coronary Disease
SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1?-dependent pathway.
Diabetes Mellitus
SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression.
Diabetes Mellitus
The role of adipose-derived inflammatory cytokines in type 1 diabetes.
Diabetes Mellitus, Type 2
How do reducing equivalents increase insulin secretion?
Diabetes Mellitus, Type 2
Senp2 expression was induced by chronic glucose stimulation in INS1 cells, and it was required for the associated induction of Ccnd1 and Mafa.
Diabetic Retinopathy
SENP1-Mediated Desumoylation of DBC1 Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes.
Drug-Related Side Effects and Adverse Reactions
Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV.
Epilepsy
Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior.
Epstein-Barr Virus Infections
The Epstein-Barr Virus Oncoprotein, LMP1, Regulates the Function of SENP2, a SUMO-protease.
Fatty Liver
Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk.
Glioblastoma
Norcantharidin modulates miR-655-regulated SENP6 protein translation to suppresses invasion of glioblastoma cells.
Glioblastoma
SUMOylation Regulator-Related Molecules Can Be Used as Prognostic Biomarkers for Glioblastoma.
Glioma
Downregulation of SENP1 inhibits cell proliferation, migration and promotes apoptosis in human glioma cells.
Glucose Intolerance
?-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High Fat Diet-Fed Mice.
Glucose Intolerance
How do reducing equivalents increase insulin secretion?
Glucose Intolerance
Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional ? cells.
Glucose Intolerance
SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression.
Head and Neck Neoplasms
Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers.
Heart Defects, Congenital
Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.
Heart Defects, Congenital
Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development.
Heart Septal Defects, Ventricular
Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.
Herpes Simplex
Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease.
Herpes Simplex
Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV.
Hyperalgesia
TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain.
Hypertension, Pulmonary
Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium.
Hypertension, Pulmonary
[The expression and possible role of SENP1 in the pulmonary vascular wall of rat during the development of hypoxic pulmonary hypertension].
Infarction, Middle Cerebral Artery
SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion.
Infections
Cardiomyocyte-specific deletion of Senp2 contributes to CVB3 viral replication and inflammation.
Infections
Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease.
Infections
SUMO Suppresses the Activity of the Jasmonic Acid Receptor CORONATINE INSENSITIVE1.
Infections
Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus.
Infections
The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression of SUMO/Sentrin-Specific Peptidase 6 To Facilitate Establishment of Latency.
Infections
[Ribosomal Protein S9 Expression in Multiple Myeloma and Its Effect on Cell Biological Function].
Insulin Resistance
SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression.
Insulin Resistance
Senp2 Regulates Adipose Lipid Storage by De-SUMOylation of Setdb1.
Insulin Resistance
SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle.
Ischemic Stroke
Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis.
Laryngeal Neoplasms
Detection of differentially expressed genes and association with clinicopathological features in laryngeal squamous cell carcinoma.
Leukemia
Deficiency of SUMO-specific protease 1 induces arsenic trioxide-mediated apoptosis by regulating XBP1 activity in human acute promyelocytic leukemia.
Leukemia
Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts.
Leukemia
SUMO-specific protease 2 in Mdm2-mediated regulation of p53.
Leukemia, Lymphocytic, Chronic, B-Cell
SENP2 exerts an anti?tumor effect on chronic lymphocytic leukemia cells through the inhibition of the Notch and NF??B signaling pathways.
Leukemia, Promyelocytic, Acute
Deficiency of SUMO-specific protease 1 induces arsenic trioxide-mediated apoptosis by regulating XBP1 activity in human acute promyelocytic leukemia.
Liver Cirrhosis
SENP1 attenuates the liver fibrosis through down-regulating the expression of SMAD2.
Lung Injury
Role of the SENP1-SIRT1 pathway in hyperoxia-induced alveolar epithelial cell injury.
Lung Neoplasms
Inhibition of SENP1 induces radiosensitization in lung cancer cells.
Lung Neoplasms
Up-regulation of microRNA-138 induce radiosensitization in lung cancer cells.
Lymphatic Metastasis
Association of SENPs single-nucleotide polymorphism and breast cancer in Chinese population.
Lymphatic Metastasis
Plasma Exosome-Derived SENP1 May Be a Potential Prognostic Predictor for Melanoma.
Lymphatic Metastasis
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9.
Lymphoma
SUMOylation Confers Posttranslational Stability on NPM-ALK Oncogenic Protein.
Melanoma
Plasma Exosome-Derived SENP1 May Be a Potential Prognostic Predictor for Melanoma.
Multiple Myeloma
SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-?B signaling.
Multiple Myeloma
Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-?B Through the Modulation of I?B? Sumoylation.
Myocarditis
Cardiomyocyte-specific deletion of Senp2 contributes to CVB3 viral replication and inflammation.
Neoplasm Metastasis
A SUMOylation-dependent HIF-1?/CLDN6 negative feedback mitigates hypoxia-induced breast cancer metastasis.
Neoplasm Metastasis
Association of SENPs single-nucleotide polymorphism and breast cancer in Chinese population.
Neoplasm Metastasis
Depletion of SENP1 suppresses the proliferation and invasion of triple-negative breast cancer cells.
Neoplasm Metastasis
Discovery of a Class of Potent and Selective Non-competitive Sentrin-Specific Protease 1 Inhibitors.
Neoplasm Metastasis
Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort.
Neoplasm Metastasis
Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer.
Neoplasm Metastasis
miR-1236 regulates hypoxia-induced epithelial-mesenchymal transition and cell migration/invasion through repressing SENP1 and HDAC3.
Neoplasm Metastasis
Plasma Exosome-Derived SENP1 May Be a Potential Prognostic Predictor for Melanoma.
Neoplasm Metastasis
Plasma Exosome-Derived Sentrin SUMO-Specific Protease 1: A Prognostic Biomarker in Patients With Osteosarcoma.
Neoplasm Metastasis
SENP2 regulates MMP13 expression in a bladder cancer cell line through SUMOylation of TBL1/TBLR1.
Neoplasm Metastasis
SENP2 suppresses epithelial-mesenchymal transition of bladder cancer cells through deSUMOylation of TGF-?RI.
Neoplasm Metastasis
Small ubiquitin-like modifier/sentrin-specific peptidase 1 associates with chemotherapy and is a risk factor for poor prognosis of non-small cell lung cancer.
Neoplasm Metastasis
Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7.
Neoplasm Metastasis
SUMO-specific protease 1 promotes prostate cancer progression and metastasis.
Neoplasm Metastasis
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9.
Neoplasm Metastasis
SUMO-Specific Protease 2 Suppresses Cell Migration and Invasion through Inhibiting the Expression of MMP13 in Bladder Cancer Cells.
Neoplasms
A cellular and bioinformatics analysis of the SENP1 SUMO isopeptidase in pancreatic cancer.
Neoplasms
ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis.
Neoplasms
Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers.
Neoplasms
Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression.
Neoplasms
Depletion of SENP1 suppresses the proliferation and invasion of triple-negative breast cancer cells.
Neoplasms
Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors.
Neoplasms
Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition.
Neoplasms
Differential regulation of sentrinized proteins by a novel sentrin-specific protease.
Neoplasms
Downregulation of SENP1 inhibits cell proliferation, migration and promotes apoptosis in human glioma cells.
Neoplasms
Downregulation of SENP1 suppresses LPS-induced macrophage inflammation by elevating Sp3 SUMOylation and disturbing Sp3-NF-?B interaction.
Neoplasms
E3 ubiquitin ligase SMURF2 prevents colorectal cancer by reducing the stability of the YY1 protein and inhibiting the SENP1/c-myc axis.
Neoplasms
Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort.
Neoplasms
Exploring the Desumoylation Process of SENP1: A Study Combined MD Simulations with QM/MM Calculations on SENP1-SUMO1-RanGAP1.
Neoplasms
Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer.
Neoplasms
Ginger DNA transposons in eukaryotes and their evolutionary relationships with long terminal repeat retrotransposons.
Neoplasms
Identification and Characterization of a New Chemotype of Noncovalent SENP Inhibitors.
Neoplasms
Identification of novel anti-cancer agents, applying in silico method for SENP1 protease inhibition.
Neoplasms
Identification of SENP1 inhibitors through in silico screening and rational drug design.
Neoplasms
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells.
Neoplasms
microRNA-186 Suppresses Cell Proliferation and Metastasis Through Targeting Sentrin Specific Protease 1 in Renal Cell Carcinoma.
Neoplasms
MiR-133a-3p Targets SUMO-Specific Protease 1 to Inhibit Cell Proliferation and Cell Cycle Progress in Colorectal Cancer.
Neoplasms
Norcantharidin modulates miR-655-regulated SENP6 protein translation to suppresses invasion of glioblastoma cells.
Neoplasms
Plasma Exosome-Derived SENP1 May Be a Potential Prognostic Predictor for Melanoma.
Neoplasms
Plasma Exosome-Derived Sentrin SUMO-Specific Protease 1: A Prognostic Biomarker in Patients With Osteosarcoma.
Neoplasms
Prognostic impact of SUMO-specific protease 1 (SENP1) in prostate cancer patients undergoing radical prostatectomy.
Neoplasms
Role of desumoylation in the development of prostate cancer.
Neoplasms
Salivary proteomics of canine oral tumors using MALDI-TOF mass spectrometry and LC-tandem mass spectrometry.
Neoplasms
SENP1 activity sustains cancer stem cell in hypoxic HCC.
Neoplasms
SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms.
Neoplasms
SENP1 Interacts with HIF1? to Regulate Glycolysis of Prostatic Carcinoma Cells.
Neoplasms
SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T.
Neoplasms
SENP1 promotes hypoxia-induced cancer stemness by HIF-1? deSUMOylation and SENP1/HIF-1? positive feedback loop.
Neoplasms
SENP1 promotes MCL pathogenesis through regulating JAK-STAT5 pathway and SOCS2 expression.
Neoplasms
SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis.
Neoplasms
SENP2 exerts an anti?tumor effect on chronic lymphocytic leukemia cells through the inhibition of the Notch and NF??B signaling pathways.
Neoplasms
SENP2 regulated the stability of ?-catenin through WWOX in hepatocellular carcinoma cell.
Neoplasms
SENP2 regulates hepatocellular carcinoma cell growth by modulating the stability of ?-catenin.
Neoplasms
SENP2 suppresses epithelial-mesenchymal transition of bladder cancer cells through deSUMOylation of TGF-?RI.
Neoplasms
SENP3 loss promotes M2 macrophage polarization and breast cancer progression.
Neoplasms
Small ubiquitin-like modifier/sentrin-specific peptidase 1 associates with chemotherapy and is a risk factor for poor prognosis of non-small cell lung cancer.
Neoplasms
SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase.
Neoplasms
SUMO protease SENP1 deSUMOylates and stabilizes c-Myc.
Neoplasms
SUMO Protease SMT7 Modulates Ribosomal Protein L30 and Regulates Cell-size Checkpoint Function.
Neoplasms
SUMO-specific protease 1 promotes prostate cancer progression and metastasis.
Neoplasms
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9.
Neoplasms
SUMO-specific protease 2 (SENP2) functions as a tumor suppressor in osteosarcoma via SOX9 degradation.
Neoplasms
SUMO-Specific Protease 2 Suppresses Cell Migration and Invasion through Inhibiting the Expression of MMP13 in Bladder Cancer Cells.
Neoplasms
SUMO-specific protease 2-mediated deSUMOylation is required for NDRG2 stabilization in gastric cancer cells.
Neoplasms
Sumoylation Negatively Regulates CSR1-Dependent Prostate Cancer Cell Death.
Neoplasms
The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms.
Neoplasms
The prognostic value of SUMO1/Sentrin specific peptidase 1 (SENP1) in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletion.
Neoplasms
The role of sentrin-specific protease 2 substrate recognition in TGF-?-induced tumorigenesis.
Neoplasms
The SUMO-specific protease family regulates cancer cell radiosensitivity.
Neoplasms
The SUMO-specific protease SENP1 deSUMOylates p53 and regulates its activity.
Neoplasms
Tumor-suppressive microRNA-145 induces growth arrest by targeting SENP1 in human prostate cancer cells.
Neoplasms
Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors.
Neuroblastoma
SENP1 regulates cell migration and invasion in neuroblastoma.
Neurodegenerative Diseases
Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration.
Neurodegenerative Diseases
SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation.
Neuroinflammatory Diseases
Depletion of SENP1-mediated PPAR? SUMOylation exaggerates intermittent hypoxia-induced cognitive decline by aggravating microglia-mediated neuroinflammation.
Neuroinflammatory Diseases
Ethanol Exposure Induces Microglia Activation and Neuroinflammation through TLR4 Activation and SENP6 Modulation in the Adolescent Rat Hippocampus.
Neuroinflammatory Diseases
SENP1 modulates microglia-mediated neuroinflammation toward intermittent hypoxia-induced cognitive decline through the de-SUMOylation of NEMO.
Obesity
Senp2 Regulates Adipose Lipid Storage by De-SUMOylation of Setdb1.
Obesity
SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle.
Osteosarcoma
Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV.
Osteosarcoma
Plasma Exosome-Derived Sentrin SUMO-Specific Protease 1: A Prognostic Biomarker in Patients With Osteosarcoma.
Osteosarcoma
SUMO-specific protease 2 (SENP2) functions as a tumor suppressor in osteosarcoma via SOX9 degradation.
Osteosarcoma
[Corrigendum] Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV.
Ovarian Neoplasms
SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1?.
Ovarian Neoplasms
SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance.
Pancreatic Neoplasms
A cellular and bioinformatics analysis of the SENP1 SUMO isopeptidase in pancreatic cancer.
Pancreatic Neoplasms
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9.
Paralysis
Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration.
Placental Insufficiency
The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.
Polycythemia
Interaction of CARD14, SENP1 and VEGFA polymorphisms on susceptibility to high altitude polycythemia in the Han Chinese population at the Qinghai-Tibetan Plateau.
Polycythemia
Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease.
Primary Ovarian Insufficiency
Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression.
Prostatic Intraepithelial Neoplasia
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells.
Prostatic Intraepithelial Neoplasia
Role of desumoylation in the development of prostate cancer.
Prostatic Intraepithelial Neoplasia
SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms.
Prostatic Neoplasms
Assays for Investigating deSUMOylation Enzymes.
Prostatic Neoplasms
CDX2/mir-145-5p/SENP1 Pathways Affect LNCaP Cells Invasion and Migration.
Prostatic Neoplasms
Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors.
Prostatic Neoplasms
Discovery of a Class of Potent and Selective Non-competitive Sentrin-Specific Protease 1 Inhibitors.
Prostatic Neoplasms
Identification of SENP1 inhibitors through in silico screening and rational drug design.
Prostatic Neoplasms
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells.
Prostatic Neoplasms
MiR-133a-3p Targets SUMO-Specific Protease 1 to Inhibit Cell Proliferation and Cell Cycle Progress in Colorectal Cancer.
Prostatic Neoplasms
Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation.
Prostatic Neoplasms
Role of desumoylation in the development of prostate cancer.
Prostatic Neoplasms
SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms.
Prostatic Neoplasms
SENP1 Interacts with HIF1? to Regulate Glycolysis of Prostatic Carcinoma Cells.
Prostatic Neoplasms
SENP1 regulates PTEN stability to dictate prostate cancer development.
Prostatic Neoplasms
SUMO Losing Balance: SUMO Proteases Disrupt SUMO Homeostasis to Facilitate Cancer Development and Progression.
Prostatic Neoplasms
SUMO-Specific Cysteine Protease 1 Promotes Epithelial Mesenchymal Transition of Prostate Cancer Cells via Regulating SMAD4 deSUMOylation.
Prostatic Neoplasms
SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells.
Prostatic Neoplasms
SUMO-specific protease 1 promotes prostate cancer progression and metastasis.
Prostatic Neoplasms
Sumoylation Negatively Regulates CSR1-Dependent Prostate Cancer Cell Death.
Prostatic Neoplasms
The prognostic value of SUMO1/Sentrin specific peptidase 1 (SENP1) in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletion.
Prostatic Neoplasms
Tumor-suppressive microRNA-145 induces growth arrest by targeting SENP1 in human prostate cancer cells.
Reperfusion Injury
Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis.
Respiratory Distress Syndrome, Newborn
Budesonide and Poractant Alfa prevent bronchopulmonary dysplasia via triggering SIRT1 signaling pathway.
Retinoblastoma
SUMO Protease SMT7 Modulates Ribosomal Protein L30 and Regulates Cell-size Checkpoint Function.
Rubella
HEARTBREAK Controls Post-translational Modification of INDEHISCENT to Regulate Fruit Morphology in Capsella.
Seizures
Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death.
Seizures
The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.
Sepsis
Downregulation of SENP1 suppresses LPS-induced macrophage inflammation by elevating Sp3 SUMOylation and disturbing Sp3-NF-?B interaction.
Sepsis
SUMO protease SENP1 acts as a ceRNA for TGFBR2 and thus activates TGFBR2/Smad signaling responsible for LPS-induced sepsis.
Sleep Apnea, Obstructive
SENP1-mediated NEMO de-SUMOylation inhibits intermittent hypoxia induced inflammatory response of microglia in vitro.
Starvation
SENP2-PLC?4 signaling regulates neurogenesis through the maintenance of calcium homeostasis.
Stomach Neoplasms
Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors.
Stomach Neoplasms
SUMO-specific protease 2-mediated deSUMOylation is required for NDRG2 stabilization in gastric cancer cells.
Stomach Neoplasms
SUMO-specific protease 6 promotes gastric cancer cell growth via deSUMOylation of FoxM1.
Stroke
Role of pericyte-derived SENP1 in neuronal injury after brain ischemia.
Teratoma
Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25).
Thrombosis
Role of pericyte-derived SENP1 in neuronal injury after brain ischemia.
Triple Negative Breast Neoplasms
Depletion of SENP1 suppresses the proliferation and invasion of triple-negative breast cancer cells.
Triple Negative Breast Neoplasms
The role of sentrin-specific protease 2 substrate recognition in TGF-?-induced tumorigenesis.
ulp1 peptidase deficiency
Deficiency of SUMO-specific protease 1 induces arsenic trioxide-mediated apoptosis by regulating XBP1 activity in human acute promyelocytic leukemia.
ulp1 peptidase deficiency
Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk.
ulp1 peptidase deficiency
Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death.
ulp1 peptidase deficiency
Inhibition of p53 deSUMOylation exacerbates puromycin aminonucleoside-induced apoptosis in podocytes.
ulp1 peptidase deficiency
Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway.
ulp1 peptidase deficiency
Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism.
ulp1 peptidase deficiency
SENP1 deficiency promotes ER stress-induced apoptosis by increasing XBP1 SUMOylation.
ulp1 peptidase deficiency
SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1.
ulp1 peptidase deficiency
SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1?-dependent pathway.
ulp1 peptidase deficiency
SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance.
ulp1 peptidase deficiency
SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism.
ulp1 peptidase deficiency
Senp2 Regulates Adipose Lipid Storage by De-SUMOylation of Setdb1.
ulp1 peptidase deficiency
SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation.
ulp1 peptidase deficiency
Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression.
ulp1 peptidase deficiency
SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function.
ulp1 peptidase deficiency
The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.
ulp1 peptidase deficiency
The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics.
Urinary Bladder Neoplasms
Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts.
Urinary Bladder Neoplasms
SENP2 regulates MMP13 expression in a bladder cancer cell line through SUMOylation of TBL1/TBLR1.
Urinary Bladder Neoplasms
SENP2 suppresses epithelial-mesenchymal transition of bladder cancer cells through deSUMOylation of TGF-?RI.
Urinary Bladder Neoplasms
SUMO-Specific Protease 2 Suppresses Cell Migration and Invasion through Inhibiting the Expression of MMP13 in Bladder Cancer Cells.
Virus Diseases
Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5.
Vitiligo
Decreased SUMOylation of the retinoblastoma protein in keratinocytes during the pathogenesis of vitiligo.
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3.4.22.68 Ulp1 peptidase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
