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Information on EC 3.4.22.65 - peptidase 1 (mite)
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3.4.22.65 peptidase 1 (mite)Specify your search results
Word Map
- 3.4.22.65
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allergic
- asthma
- ige
- dermatophagoides
- pteronyssinus
- children
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home
-
asthmatic
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atopic
- farinae
- airway
-
indoor
-
immunotherapy
-
mattress
- bronchial
- rhinitis
-
inhale
-
prick
-
allergen-specific
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floor
-
carpet
-
bedroom
- dermatitis
-
humid
-
hyperresponsiveness
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airborne
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household
-
houses
- cockroach
-
aeroallergens
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vacuum
-
wheeze
-
house-dust
-
ige-binding
-
cleaner
- ras
- blomia
-
anti-der
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allergen-induced
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rhinoconjunctivitis
-
component-resolved
-
mite-induced
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radioallergosorbent
- diagnostics
-
hdm-induced
-
hypoallergenic
- pharmacology
-
nonatopic
- medicine
-
wheal
-
immunocap
-
dander
-
skin-prick
- drug development
The enzyme appears in viruses and cellular organisms
Reaction Schemes
broad endopeptidase specificity
the proteolytic activity of Der f 1 is a major contributor to its allergenicity. Cysteine protease activity of Der p 1 enhances total IgE production
Synonyms
der p 1, mite allergen, der f 1, house dust mite allergen, der p1, house dust mite allergens, der f1, der p 7, allergen der p 1, allergen der p, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
allergen Der f1
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CO1.073
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Der f 1
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Der p 1
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Z-Phe-Arg-4-methylcoumarin 7-amide + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
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additional information
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Der p 7 binds a bacterially-derived lipid product, a common feature of some allergens, ligand binding analysis by NMR analysis
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Airway Obstruction
Principal components analysis of atopy-related traits in a random sample of children.
Anaphylaxis
Clinical case of anaphylaxis with sublingual immunotherapy: house dust mite allergen.
Anaphylaxis
High-dose cutaneous exposure to mite allergen induces IgG-mediated protection against anaphylaxis.
Asthma
A cohort study of indoor nitrogen dioxide and house dust mite exposure in asthmatic children.
Asthma
A Fusion Protein of Derp2 Allergen and Flagellin Suppresses Experimental Allergic Asthma.
Asthma
A meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement.
Asthma
A nonsynonymous substitution of cystatin A, a cysteine protease inhibitor of house dust mite protease, leads to decreased mRNA stability and shows a significant association with atopic dermatitis.
Asthma
A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children.
Asthma
A randomized controlled trial of mite allergen-impermeable bed covers in adult mite-sensitized asthmatics.
Asthma
A recombinant group 1 house dust mite allergen, rDer f 1, with biological activities similar to those of the native allergen.
Asthma
A reintroduction of environmental mite allergen control strategies for asthma treatment and the debate on their effectiveness.
Asthma
A two-site monoclonal antibody ELISA for the quantification of the major Dermatophagoides spp. allergens, Der p I and Der f I.
Asthma
Activation of mas-related G-protein coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation.
Asthma
Acute and Subacute Oral Toxicity of Deoxynivalenol Exposure in a Dermatophagoides farinae-Induced Murine Asthma Model.
Asthma
Administration of interleukin-12 prevents mite Der p 1 allergen-IgE antibody production and airway eosinophil infiltration in an animal model of airway inflammation.
Asthma
Allergen exposure in infancy and the development of sensitization, wheeze, and asthma at 4 years.
Asthma
Allergen-specific IgE levels and mite allergen exposure in children with acute asthma first seen in an emergency department and in nonasthmatic control subjects.
Asthma
Allergenic differences between the domestic mites Blomia tropicalis and Dermatophagoides pteronyssinus.
Asthma
An ELISA for recombinant Lepidoglyphus destructor, Lep d 2, and the monitoring of exposure to dust mite allergens in farming households.
Asthma
Analysis of mechanism of PM2.5 and house dust mite antigen Der p1 in attack stage of child asthma.
Asthma
Analysis of the immunoglobin E molecular sensitization profile in children with allergic asthma and predictive factors for the efficacy of allergy immunotherapy.
Asthma
Association Between Asthma and Sensitization to Allergens of Dermatophagoides pteronyssinus.
Asthma
Association between endotoxin and mite allergen exposure with asthma and specific sensitization at age 7 in high-risk children.
Asthma
Association between Temporary Housing Habitation after the 2011 Japan Earthquake and Mite Allergen Sensitization and Asthma Development.
Asthma
Association of pediatric asthma severity with exposure to common household dust allergens.
Asthma
Asthma severity and morbidity in a population sample of Sydney schoolchildren: Part II--Importance of house dust mite allergens.
Asthma
Asthma, Airway Symptoms and Rhinitis in Office Workers in Malaysia: Associations with House Dust Mite (HDM) Allergy, Cat Allergy and Levels of House Dust Mite Allergens in Office Dust.
Asthma
Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment.
Asthma
Augmented angiogenic transcription factor, SOX18, is associated with asthma exacerbation.
Asthma
Benzo(a)pyrene Enhanced Dermatophagoides Group 1 (Der f 1)-Induced TGF?1 Signaling Activation Through the Aryl Hydrocarbon Receptor-RhoA Axis in Asthma.
Asthma
Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)-induced epithelial cytokine release through aryl hydrocarbon receptor in asthma.
Asthma
Biologic pollution in infant bedding in New Zealand: high allergen exposure during a vulnerable period.
Asthma
Bronchial allergen challenge with isolated major allergens of Dermatophagoides pteronyssinus: the role of patient characteristics in the early asthmatic response.
Asthma
Bronchial asthma, sensitisation and exposure to Der p1 and Der f1 in an Andean Ecuadorian school.
Asthma
Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases: a study with allergen-specific human helper T cells.
Asthma
Characteristics and management of sublingual allergen immunotherapy in children with allergic rhinitis and asthma induced by house dust mite allergens.
Asthma
Characterization of allergens and airborne fungi in low and middle-income homes of primary school children in Durban, South Africa.
Asthma
Characterization of Der p 21, a new important allergen derived from the gut of house dust mites.
Asthma
Childhood asthma and early life exposure to indoor allergens, endotoxin and beta(1,3)-glucans.
Asthma
Clinical and immunologic effects of long-term sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, placebo-controlled study.
Asthma
Clinical and immunologic effects of sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, randomized, placebo-controlled study.
Asthma
Clinical evaluation of the effect of anti-allergic mattress covers in patients with moderate to severe asthma and house dust mite allergy: a randomised double blind placebo controlled study.
Asthma
Cloning and expression of Blo t 1, a novel allergen from the dust mite Blomia tropicalis, homologous to cysteine proteases.
Asthma
Cloning and expression of Der f 6, a serine protease allergen from the house dust mite, Dermatophagoides farinae.
Asthma
Clostridium butyricum in combination with specific immunotherapy converts antigen-specific B cells to regulatory B cells in asthmatic patients.
Asthma
Comparison between the Acarex R test and a Der p 1 ELISA for the detection of house-dust mites in the homes of asthma sufferers.
Asthma
Comparison of indoor allergens, allergic scores, and demographic data in Taiwanese adults with asthma or allergic rhinitis, or both.
Asthma
Comparison of intradermal skin testing (IDST) and serum allergen-specific IgE determination in an experimental model of feline asthma.
Asthma
Comparison of the roles of house dust mite allergens, ovalbumin and lipopolysaccharides in the sensitization of mice to establish a model of severe neutrophilic asthma.
Asthma
Component-resolved diagnosis with commercially available d. Pteronyssinus der p 1, der p 2, and der p 10: relevant markers for house dust mite allergy.
Asthma
Component-Resolved Diagnostic Study of Dermatophagoides Pteronyssinus Major Allergen Molecules in a Southern Chinese Cohort.
Asthma
Concentrations of cysteinyl leukotrienes in urine and bronchoalveolar lavage fluid of cats with experimentally induced asthma.
Asthma
Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma.
Asthma
Correlates of sensitization to Blomia tropicalis and Dermatophagoides pteronyssinus in asthma in Barbados.
Asthma
Cost-effectiveness of the subcutaneous house dust mite allergen immunotherapy plus pharmacotherapy for allergic asthma: A mathematical model.
Asthma
Current eczema in children is related to Der f 1 exposure but not to Der p 1 exposure.
Asthma
Current indoor allergen levels of fungi and cats, but not house dust mites, influence allergy and asthma in adults with high dust mite exposure.
Asthma
Dental Follicle Mesenchymal Stem Cells Downregulate Th2 Mediated Immune Response in Asthmatic Patients Mononuclear Cells.
Asthma
Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma.
Asthma
Der p 2.1 Peptide Abrogates House Dust Mites-Induced Asthma Features in Mice and Humanized Mice by Inhibiting DC-Mediated T Cell Polarization.
Asthma
Der p 5 allergen from house dust mite: first epitope mapping of rabbit IgG blocking antibodies.
Asthma
Dermatophagoides farinae (Der f 1) and Dermatophagoides pteronyssinus (Der p 1) allergen exposure among subjects living in Uberlândia, Brazil.
Asthma
Dermatophagoides pteronyssinus and bioelectric properties of airway epithelium: role of cysteine proteases.
Asthma
Dermatophagoides pteronyssinus-induced pro-inflammatory responses mediated via STAT3 and NF-kappaB signaling pathways in human bronchial epithelial cells - Inhibitory effects of Lafoensia pacari and ellagic acid.
Asthma
Desensitization of the adenylyl cyclase system in peripheral blood mononuclear cells from patients with asthma three hours after allergen challenge.
Asthma
Design of a ProDer f 1 vaccine delivered by the MHC class II pathway of antigen presentation and analysis of the effectiveness for specific immunotherapy.
Asthma
Differences in response of patient's blood cells with bronchial asthma to diverse house dust mite allergens by histamine release assay.
Asthma
Double blind trial of ionisers in children with asthma sensitive to the house dust mite.
Asthma
Dust mite allergen Der f 4: Expression, characterization, and IgE-binding in pediatric asthma.
Asthma
Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations.
Asthma
Early sensitisation and development of allergic airway disease - risk factors and predictors.
Asthma
Effect of activation of Toll-like receptor 7 in the inhibition of allergic asthma on a mouse model.
Asthma
Effect of bedding control on amount of house dust mite allergens, asthma symptoms, and peak expiratory flow rate.
Asthma
Effect of current exposure to Der p 1 on asthma symptoms, airway inflammation, and bronchial hyperresponsiveness in mite-allergic asthmatics.
Asthma
Effect of improved home ventilation on asthma control and house dust mite allergen levels.
Asthma
Effect of PM2.5 mediated oxidative stress on the innate immune cellular response of Der p1 treated human bronchial epithelial cells.
Asthma
Effect of saiboku-to (TJ-96) on bronchial asthma. Induction of glucocorticoid receptor, beta-adrenaline receptor, IgE-Fc epsilon receptor expression and its effect on experimental immediate and late asthmatic reaction.
Asthma
Effects of astragaloside IV on eosinophil activation induced by house dust mite allergen.
Asthma
Effects of physical interventions on house dust mite allergen levels in carpet, bed, and upholstery dust in low-income, urban homes.
Asthma
Efficacies of immunotherapy with polypeptide vaccine from ProDer f 1 in asthmatic mice.
Asthma
Efficacy evaluation of Der p 1 DNA vaccine for allergic asthma in an experimental mouse model.
Asthma
Efficacy of sublingual immunotherapy with high-dose mite extracts in asthma: a multi-center, double-blind, randomized, and placebo-controlled study in Taiwan.
Asthma
Eliminating Dermatophagoides farinae spp. (Acari: Pyroglyphidae) and their allergens through high temperature treatment of textiles.
Asthma
Endotoxin and Der p1 allergen levels in indoor air and settled dust in day-care centers in Tehran, Iran.
Asthma
Endotoxin exposure in asthmatic children and matched healthy controls: results of IPEADAM study.
Asthma
Environmental interventions for mite-induced asthma: a journey between systematic reviews, contrasting evidence and clinical practice.
Asthma
Environmental prevention in atopic eczema dermatitis syndrome (AEDS) and asthma: avoidance of indoor allergens.
Asthma
Environmental Tobacco Smoke and Progesterone Alter Lung Inflammation and Mucous Metaplasia in a Mouse Model of Allergic Airway Disease.
Asthma
Evaluation of the relationship between cockroach sensitivity and house-dust-mite sensitivity in Turkish asthmatic patients.
Asthma
Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life.
Asthma
Exposure and sensitization to dust mite allergens among asthmatic children in São Paulo, Brazil.
Asthma
Exposure to a high concentration of mite allergen in early infancy is a risk factor for developing atopic dermatitis: a 3-year follow-up study.
Asthma
Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age.
Asthma
Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood.
Asthma
Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study.
Asthma
Exposure to indoor allergens in homes of patients with asthma and/or rhinitis in southeast Brazil: effect of mattress and pillow covers on mite allergen levels.
Asthma
Exposures in the Indoor Environment and Prevalence of Allergic Conditions in the United States of America.
Asthma
Expression and immunogenicity of the major house dust mite allergen Der p 1 following DNA immunization.
Asthma
Expression and refolding of mite allergen pro-Der f1 from inclusion bodies in Escherichia coli.
Asthma
Expression cloning of a dust mite cysteine proteinase, Der p1, a major allergen associated with asthma and hypersensitivity reactions.
Asthma
Family history, dust mite exposure in early childhood, and risk for pediatric atopy and asthma.
Asthma
Genome-wide interaction study of dust mite allergen on lung function in children with asthma.
Asthma
Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells.
Asthma
High-level expression in mammalian cells of recombinant house dust mite allergen ProDer p 1 with optimized codon usage.
Asthma
Higher fractional exhaled nitric oxide and Der p 1 exposure in children with asthma living in tropical environments.
Asthma
Homology modeling and prediction of B?cell and T?cell epitopes of the house dust mite allergen Der f 20.
Asthma
House dust mite allergen avoidance and self-management in allergic patients with asthma: randomised controlled trial.
Asthma
House dust mite allergen avoidance in asthma. Benefits unproved but not yet excluded.
Asthma
House dust mite allergen causes certain features of steroid resistant asthma in high fat fed obese mice.
Asthma
House dust mite allergen in US beds: results from the First National Survey of Lead and Allergens in Housing.
Asthma
House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells.
Asthma
House dust mite allergen levels and an anti-mite mattress spray (natamycin) in the treatment of childhood asthma.
Asthma
House dust mite allergen reduction and allergy at 4 yr: follow up of the PIAMA-study.
Asthma
House dust mite control measures for asthma.
Asthma
House dust mite major allergens Der p1 and Der p5 activate human airway-derived epithelial cells by protease-dependent and protease-independent mechanisms.
Asthma
House Dust Mite Sublingual Immunotherapy for Pediatric Patients With Allergic Asthma.
Asthma
House dust mite sublingual immunotherapy is safe and appears to be effective in moderate, persistent asthma.
Asthma
How clean is your house? A study of house dust mites, allergens and other contents of dust samples collected from households.
Asthma
IgE responses to Dermatophagoides pteronyssinus native major allergens Der p 1 and Der p 2 during long-term specific immunotherapy.
Asthma
IL-4 production by PBMCs on stimulation with mite allergen is correlated with the level of serum IgE antibody against mite in children with bronchial asthma.
Asthma
Importance of house dust mite and Alternaria allergens in childhood asthma: an epidemiological study in two climatic regions of Australia.
Asthma
In planta expression of a mature Der p 1 allergen isolated from an Italian strain of Dermatophagoides pteronyssinus.
Asthma
Indoor Determinants of Endotoxin and Dust Mite Exposures in Hong Kong Homes with Asthmatic Children.
Asthma
Indoor microbiome, environmental characteristics and asthma among junior high school students in Johor Bahru, Malaysia.
Asthma
Indoor mite allergens in patients with respiratory allergy living in Porto, Portugal.
Asthma
Induction of IgE-Fc receptor (Fc epsilon R2/CD23) expression on lymphocytes from patients with mite-allergic bronchial asthma by mite allergen.
Asthma
Inhaled formaldehyde exposure: effect on bronchial response to mite allergen in sensitized asthma patients.
Asthma
Inhibition of the late asthmatic response to house dust mite by non-steroidal anti-inflammatory drugs.
Asthma
Inhibitory effect of pulmonary surfactant proteins A and D on allergen-induced lymphocyte proliferation and histamine release in children with asthma.
Asthma
Interleukin-1 production by monocytes from patients with allergic asthma after stimulation in vitro with lipopolysaccharide and Dermatophagoides pteronyssinus mite allergen.
Asthma
Lipophilic Allergens, Different Modes of Allergen-Lipid Interaction and Their Impact on Asthma and Allergy.
Asthma
Lung function at one month of age as a risk factor for infant respiratory symptoms in a high risk population.
Asthma
Major house dust mite allergens Dermatophagoides pteronyssinus 1 and Dermatophagoides farinae 1 degrade and inactivate lung surfactant proteins A and D.
Asthma
Manchester Asthma and Allergy Study: low-allergen environment can be achieved and maintained during pregnancy and in early life.
Asthma
Mattress encasings and mite allergen levels in the Prevention and Incidence of Asthma and Mite Allergy study.
Asthma
Mechanical ventilation and high-efficiency vacuum cleaning: A combined strategy of mite and mite allergen reduction in the control of mite-sensitive asthma.
Asthma
Meta-Transcriptomic Analysis Reveals the Virome and Viral Genomic Evolution of Medically Important Mites.
Asthma
MHC class II-restricted presentation of the major house dust mite allergen Der p 1 Is GILT-dependent: implications for allergic asthma.
Asthma
Mite allergen (Der p 1) concentration in houses and its relation to the presence and severity of asthma in a population of Sydney schoolchildren.
Asthma
Mite allergen decreases DC-SIGN expression and modulates human dendritic cell differentiation and function in allergic asthma.
Asthma
Mite allergens in relation to home conditions and sensitization of asthmatic children from three climatic regions.
Asthma
Mite and cockroach allergens activate protease-activated receptor 2 and delay epidermal permeability barrier recovery.
Asthma
Mite and pet allergen levels in homes of children born to allergic and nonallergic parents: the PIAMA study.
Asthma
Mite sensitization in the Scandinavian countries and factors influencing exposure levels.
Asthma
Mite, cat, and cockroach exposure, allergen sensitisation, and asthma in children: a case-control study of three schools.
Asthma
Molecular cloning, expression, sequence analyses of dust mite allergen Der f 6 and its IgE-binding reactivity with mite allergic asthma patients in southeast China.
Asthma
Murine allergic respiratory responses to the major house dust mite allergen Der p 1.
Asthma
Natural exposure and serum antibodies to house dust mite of mite-allergic children with asthma in Atlanta.
Asthma
Nonlinear relationship of mite allergen exposure to mite sensitization and asthma in a birth cohort.
Asthma
Orchestration of an uncommon maturation cascade of the house dust mite protease allergen quartet.
Asthma
Paternal asthma, mold exposure, and increased airway responsiveness among children with asthma in Costa Rica.
Asthma
Placental Growth Factor Contributes to Bronchial Neutrophilic Inflammation and Edema in Allergic Asthma.
Asthma
Prevalence of sensitivity to cockroach allergens and IgE cross-reactivity between cockroach and house dust mite allergens in Chinese patients with allergic rhinitis and asthma.
Asthma
Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression.
Asthma
Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study.
Asthma
Principal components analysis of atopy-related traits in a random sample of children.
Asthma
Proasthmatic effects and mechanisms of action of the dust mite allergen, Der p 1, in airway smooth muscle.
Asthma
Purification and characterization of a 94 KD high molecular weight allergen from house dust mite, Dermatophagoides pteronyssinus.
Asthma
Reactivity to recombinant house-dust-mite allergens in asthma and rhinitis in a tropical environment.
Asthma
Recruited Alveolar Macrophages, in Response to Airway Epithelial-derived MCP-1/CCL2, Regulate Airway Inflammation and Remodeling in Allergic Asthma.
Asthma
Reducing domestic exposure to dust mite allergen reduces bronchial hyperreactivity in sensitive children with asthma.
Asthma
Relationship between active and passive smoking and total serum IgE levels in Japanese women: baseline data from the Osaka Maternal and Child Health Study.
Asthma
Relationship of house-dust mite allergen exposure in children's bedrooms in infancy to bronchial hyperresponsiveness and asthma diagnosis by age 6 to 7.
Asthma
Relationships between duration of asthma and asthma severity among children in the Childhood Asthma Management Program (CAMP)
Asthma
Respiratory symptoms in relation to indoor exposure to mite and cat allergens and endotoxins. Indoor Factors and Genetics in Asthma (INGA) Study Group.
Asthma
Resuspension of indoor aeroallergens and relationship to lung inflammation in asthmatic children.
Asthma
Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model.
Asthma
Safety and efficacy of salbutamol aerosol on Dermatophagoides farinae induced bronchospasm in asthmatic patients.
Asthma
Safety of semi-depot house dust mite allergen extract in children and adolescents with allergic rhinitis and asthma.
Asthma
Schistosoma mansoni antigens alter activation markers and cytokine profile in lymphocytes of patients with asthma.
Asthma
Seasonal variation in airway hyperresponsiveness and natural exposure to house dust mite allergens in patients with asthma.
Asthma
Semi-depot house-dust mite allergen extract for Chinese with allergic rhinitis and asthma.
Asthma
Sensitivity and exposure to indoor allergens in adults with differing asthma severity.
Asthma
Sensitivity to house dust mite allergens and prevalence of allergy-causing house dust mite species in Pothwar, Pakistan.
Asthma
Sensitization profile in patients with respiratory allergic diseases: differences between conventional and molecular diagnosis (a cross-sectional study).
Asthma
Sensitization to dust mites as a dominant risk factor for asthma among adolescents living in central Virginia. Multiple regression analysis of a population-based study.
Asthma
Soy, isoflavones, and prevalence of allergic rhinitis in Japanese women: the Osaka Maternal and Child Health Study.
Asthma
Stringent environmental control in pregnancy and early life: the long-term effects on mite, cat and dog allergen.
Asthma
Subcutaneous immunotherapy with purified Der p1 and 2 suppresses type 2 immunity in a murine asthma model.
Asthma
Symptoms of wheeze and persistent cough in the first year of life: associations with indoor allergens, air contaminants, and maternal history of asthma.
Asthma
The association of smoking with sensitization to common environmental allergens: results from the European Community Respiratory Health Survey.
Asthma
The childhood asthma prevention study (CAPS): design and research protocol of a randomized trial for the primary prevention of asthma.
Asthma
The combined influence of immunotherapy and mite allergen reduction on bronchial hyperresponsiveness in mite-sensitive asthmatic children.
Asthma
The Dermatophagoides pteronyssinus Molecular Sensitization Profile of Allergic Rhinitis Patients in Central China.
Asthma
The determinants of dust mite allergen and its relationship to the prevalence of symptoms of asthma in the Asia-Pacific region.
Asthma
The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.
Asthma
The effect of changes in house dust mite allergen exposure on the severity of asthma.
Asthma
The effects of season, climate, and air-conditioning on the prevalence of Dermatophagoides mite allergens in household dust.
Asthma
The house dust mite allergen Der p1 catalytically inactivates alpha 1-antitrypsin by specific reactive centre loop cleavage: a mechanism that promotes airway inflammation and asthma.
Asthma
The Melbourne house dust mite study: eliminating house dust mites in the domestic environment.
Asthma
The Melbourne House Dust Mite Study: long-term efficacy of house dust mite reduction strategies.
Asthma
The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins.
Asthma
Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen.
Asthma
Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study.
Asthma
Time-dependent distinct roles of Toll-like receptor 4 in a house dust mite-induced asthma mouse model.
Asthma
Total and specific IgE (house dust mite and intestinal helminths) in asthmatics and controls from Gondar, Ethiopia.
Asthma
Traffic-related Air Pollution, Dust Mite Allergen, and Childhood Asthma in Puerto Ricans.
Asthma
Use of a chimeric ELISA to investigate immunoglobulin E antibody responses to Der p 1 and Der p 2 in mite-allergic patients with asthma, wheezing and/or rhinitis.
Asthma
Vaccination with different doses of Dermatophagoides farinae in a mouse model of allergic asthma.
Asthma
Vaccination with transgenic rice seed expressing mite allergen: a new option for asthma sufferers?
Asthma
Variants in TGFB1, dust mite exposure, and disease severity in children with asthma.
Asthma
Variation in the association OF Der p 1 and Der f 1 with asthma and rhinitis in 9-11 years old schoolchildren: The french six cities study.
Asthma
[An analysis of skin prick test reactivity to dust mite in overweight and normal weight children with allergic asthma before and after specific immunotherapy].
Asthma
[Detection of mite allergens in the dust of filter-net and air of air-conditioned room]
Asthma
[Effect of immunostimulatory DNA sequence on the production of Th1 and Th2 cytokines induced by Dermatophagoides farinae allergen in vitro]
Asthma
[Effect of immunotherapy of recombinant chimeric epitopes of major allergen group 1 from Dermatophagoides farina on asthma of mice].
Asthma
[Evaluation of the efficacy and safety of standardized dust mite allergen specific immunotherapy to children with allergic asthma].
Asthma
[Experimental study on the Der f 1 mRNA molecules derived from dermatophagoides farinae for specific immunotherapy on murine model of asthma].
Asthma
[House dust mite allergens and mite allergy in Copenhagen dwellings. A cross-sectional study]
Asthma
[Immunotherapeutic Effect of Dermatophagoides pteronyssinus Group 1 Allergen T Cell Epitope Peptide Against Allergic Asthma in Mice].
Asthma
[Immunotherapy effect of ploypeptide vaccine of allergen group 1 from Dermatophagoides farinae on asthma mice].
Asthma
[Induction of IgE-Fc receptor (Fc epsilon RII/CD23) expression on stimulated monocytes by mite allergen in patients with asthma]
Asthma
[Relationship between the clinical course of bronchial asthma from childhood to adulthood (deterioration/improvement), bronchial hyperreactivity and incidence of house dust mite allergens in households of persons treated for atopic bronchial asthma as children]
Asthma
[Safety analysis of dust mite allergen for diagnosis and immunotherapy of asthma and rhinitis]
Asthma
[The correlation between the seasonal variation of house dust mite allergens exposure level in household and the level of asthma control in asthmatic children].
Asthma
[The mite-free room (MFR) for the management of atopic dermatitis: living in the MFR improved first the itch and then the dermatitis]
Asthma
[The roles of adhesion molecules, cytokines, and chemokines in eosinophil activation during allergic inflammation]
Bronchial Hyperreactivity
An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma.
Bronchial Hyperreactivity
Effect of dampness at home in childhood on bronchial hyperreactivity in adolescence.
Bronchial Hyperreactivity
Reducing domestic exposure to dust mite allergen reduces bronchial hyperreactivity in sensitive children with asthma.
Bronchial Hyperreactivity
Sensitization to dust mites as a dominant risk factor for asthma among adolescents living in central Virginia. Multiple regression analysis of a population-based study.
Bronchial Hyperreactivity
The combined influence of immunotherapy and mite allergen reduction on bronchial hyperresponsiveness in mite-sensitive asthmatic children.
Bronchial Hyperreactivity
[Relationship between the clinical course of bronchial asthma from childhood to adulthood (deterioration/improvement), bronchial hyperreactivity and incidence of house dust mite allergens in households of persons treated for atopic bronchial asthma as children]
Bronchial Spasm
Inhibition of the late asthmatic response to house dust mite by non-steroidal anti-inflammatory drugs.
Bronchitis, Chronic
Lung cancer-related changing profile of B-cell epitopes recognized on mucosal antigens: the Der p1 model.
Carcinoma
A different profile of epitopic dominance in the immunoglobulin G response to bovine betalactoglobulin in lung cancer.
Carcinoma
Lung cancer-related changing profile of B-cell epitopes recognized on mucosal antigens: the Der p1 model.
Carcinoma
The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1.
Carcinoma, Squamous Cell
The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1.
Chronic Urticaria
Exacerbation of chronic urticaria in the course of house dust mite immunotherapy: Case report.
Communicable Diseases
Meta-Transcriptomic Analysis Reveals the Virome and Viral Genomic Evolution of Medically Important Mites.
Conjunctivitis, Allergic
Relationship Between Total Tear IgE and Specific Serum IgE in Autumnal Allergic Conjunctivitis.
Conjunctivitis, Allergic
Specific Tear IgE in Patients with Moderate-to-Severe Autumnal Allergic Conjunctivitis.
Dermatitis
Mite allergen induces allergic dermatitis with concomitant neurogenic inflammation in mouse.
Dermatitis, Atopic
A human-SCID mouse model for allergic immune response bacterial superantigen enhances skin inflammation and suppresses IgE production.
Dermatitis, Atopic
A new method, distribution-analyzing latex immunoassay (DALIA), to measure specific immunoglobulin G against mite and wheat allergen in human sera.
Dermatitis, Atopic
A nonsynonymous substitution of cystatin A, a cysteine protease inhibitor of house dust mite protease, leads to decreased mRNA stability and shows a significant association with atopic dermatitis.
Dermatitis, Atopic
Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients.
Dermatitis, Atopic
Basophil histamine release and airway response to mite allergen in atopic dermatitis.
Dermatitis, Atopic
Bronchial responsiveness to mite allergen in atopic dermatitis without asthma.
Dermatitis, Atopic
Changes in eosinophil and leukocyte infiltration and expression of IL-6 and IL-7 messenger RNA in mite allergen patch test reactions in atopic dermatitis.
Dermatitis, Atopic
Clinical characteristics of mite allergen specific-lymphocytes stimulation test-positive Japanese cases with adult type atopic dermatitis.
Dermatitis, Atopic
Costello syndrome model mice with a HrasG12S/+ mutation are susceptible to develop house dust mite-induced atopic dermatitis.
Dermatitis, Atopic
Current eczema in children is related to Der f 1 exposure but not to Der p 1 exposure.
Dermatitis, Atopic
Der p1 and Der p2-Specific T Cells Display a Th2, Th17, and Th2/Th17 Phenotype in Atopic Dermatitis.
Dermatitis, Atopic
Dermatophagoides farinae house dust mite allergen challenges reduce stratum corneum ceramides in an experimental dog model of acute atopic dermatitis.
Dermatitis, Atopic
Early sensitisation and development of allergic airway disease - risk factors and predictors.
Dermatitis, Atopic
Effect of house dust mite avoidance measures in children with atopic dermatitis.
Dermatitis, Atopic
Effects of maternal exposure to di-(2-ethylhexyl) phthalate during fetal and/or neonatal periods on atopic dermatitis in male offspring.
Dermatitis, Atopic
Exposure to a high concentration of mite allergen in early infancy is a risk factor for developing atopic dermatitis: a 3-year follow-up study.
Dermatitis, Atopic
Home environment and suspected atopic eczema in Japanese infants: the Osaka Maternal and Child Health Study.
Dermatitis, Atopic
Homology modeling and prediction of B?cell and T?cell epitopes of the house dust mite allergen Der f 20.
Dermatitis, Atopic
House Dust Mite allergens Der f and Der p induce IL-31 production by blood derived T cells from Atopic Dermatitis patients.
Dermatitis, Atopic
House dust mites on skin, clothes, and bedding of atopic dermatitis patients.
Dermatitis, Atopic
Immunohistochemical studies in mite antigen-induced patch test sites in atopic dermatitis.
Dermatitis, Atopic
Influence of short-term exposure to airborne Der p 1 and volatile organic compounds on skin barrier function and dermal blood flow in patients with atopic eczema and healthy individuals.
Dermatitis, Atopic
LIGHT-HVEM signaling in keratinocytes controls development of dermatitis.
Dermatitis, Atopic
Mite allergen (Der p 1) levels in houses of children with atopic dermatitis: the relationship with allergometric tests.
Dermatitis, Atopic
Mite allergen induces allergic dermatitis with concomitant neurogenic inflammation in mouse.
Dermatitis, Atopic
Mite and cockroach allergens activate protease-activated receptor 2 and delay epidermal permeability barrier recovery.
Dermatitis, Atopic
Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes.
Dermatitis, Atopic
Patch tests with house dust mite antigens in atopic dermatitis patients: methodological problems.
Dermatitis, Atopic
Peripheral blood mononuclear cell responses to major and minor Dermatophagoides allergens in canine atopic dermatitis.
Dermatitis, Atopic
Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life.
Dermatitis, Atopic
Principal components analysis of atopy-related traits in a random sample of children.
Dermatitis, Atopic
Profiles of IgE Sensitization to Der f 1, Der f 2, Der f 6, Der f 8, Der f 10, and Der f 20 in Korean House Dust Mite Allergy Patients.
Dermatitis, Atopic
Purified Der p1 and p2 patch tests in patients with atopic dermatitis: evidence for both allergenicity and proteolytic irritancy.
Dermatitis, Atopic
Relationship between active and passive smoking and total serum IgE levels in Japanese women: baseline data from the Osaka Maternal and Child Health Study.
Dermatitis, Atopic
Sensitization to various minor house dust mite allergens is greater in patients with atopic dermatitis than in those with respiratory allergic disease.
Dermatitis, Atopic
Severe atopic dermatitis is associated with a reduced frequency of IL-10 producing allergen-specific CD4+ T cells.
Dermatitis, Atopic
Size effects of polystyrene nanoparticles on atopic dermatitislike skin lesions in NC/NGA mice.
Dermatitis, Atopic
Soy, isoflavones, and prevalence of allergic rhinitis in Japanese women: the Osaka Maternal and Child Health Study.
Dermatitis, Atopic
Temporal association between Der pI exposure, immediate hypersensitivity and clinical severity of eczema.
Dermatitis, Atopic
The indoor level of house dust mite allergen is associated with severity of atopic dermatitis in children.
Dermatitis, Atopic
Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen.
Dermatitis, Atopic
Upregulation of the Release of Granulocyte-Macrophage Colony-Stimulating Factor from Keratinocytes Stimulated with Cysteine Protease Activity of Recombinant Major Mite Allergens, Der f 1 and Der p 1.
Dermatitis, Atopic
Use of an amplified ELISA technique for detection of a house dust mite allergen (Der f 1) in skin and coat dust samples from dogs.
Dermatitis, Atopic
Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: a multi-centre, randomized, dose-response study.
Dermatitis, Atopic
[Specific immunotherapy with house dust mite allergens in an adult with severe atopic dermatitis]
Dermatitis, Atopic
[The mite-free room (MFR) for the management of atopic dermatitis: living in the MFR improved first the itch and then the dermatitis]
Dyspnea
Asthma, Airway Symptoms and Rhinitis in Office Workers in Malaysia: Associations with House Dust Mite (HDM) Allergy, Cat Allergy and Levels of House Dust Mite Allergens in Office Dust.
Dyspnea
Respiratory symptoms in relation to indoor exposure to mite and cat allergens and endotoxins. Indoor Factors and Genetics in Asthma (INGA) Study Group.
Eczema
Beneficial effects of tissue inhibitor of metalloproteinases-2 (TIMP-2) on chronic dermatitis.
Eczema
Costello syndrome model mice with a HrasG12S/+ mutation are susceptible to develop house dust mite-induced atopic dermatitis.
Eczema
Current eczema in children is related to Der f 1 exposure but not to Der p 1 exposure.
Eczema
Double-blind controlled trial of effect of housedust-mite allergen avoidance on atopic dermatitis.
Eczema
Establishing an allergic eczema model employing recombinant house dust mite allergens Der p 1 and Der p 2 in BALB/c mice.
Eczema
Expression and refolding of mite allergen pro-Der f1 from inclusion bodies in Escherichia coli.
Eczema
How clean is your house? A study of house dust mites, allergens and other contents of dust samples collected from households.
Eczema
Specific profiles of house dust mite sensitization in children with asthma and in children with eczema.
Eczema
Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: a multi-centre, randomized, dose-response study.
Egg Hypersensitivity
A role for early oral exposure to house dust mite allergens through breast milk in IgE-mediated food allergy susceptibility.
Eosinophilia
Absence of immunoglobulin E synthesis and airway eosinophilia by vaccination with plasmid DNA encoding ProDer p 1.
Eosinophilia
Amelioration of ovalbumin-induced allergic airway disease following Der p 1 peptide immunotherapy is not associated with induction of IL-35.
Eosinophilia
An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma.
Eosinophilia
IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation.
Eosinophilia
IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation.
Eosinophilia
Impaired mucus clearance exacerbates allergen-induced type 2 airway inflammation in juvenile mice.
Eosinophilia
Indoor insect allergens are potent inducers of experimental eosinophilic esophagitis in mice.
Eosinophilia
Probiotic E. coli Nissle 1917 activates DC and prevents house dust mite allergy through a TLR4-dependent pathway.
Exanthema
Current eczema in children is related to Der f 1 exposure but not to Der p 1 exposure.
Food Hypersensitivity
A role for early oral exposure to house dust mite allergens through breast milk in IgE-mediated food allergy susceptibility.
Food Hypersensitivity
Environmental prevention in atopic eczema dermatitis syndrome (AEDS) and asthma: avoidance of indoor allergens.
Hepatitis A
Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case-control study.
Hookworm Infections
Effect of helminthic infections together with mite allergen exposure on the risk of wheeze in preschool children.
Hookworm Infections
Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case-control study.
Hypersensitivity
A different profile of epitopic dominance in the immunoglobulin G response to bovine betalactoglobulin in lung cancer.
Hypersensitivity
A hypoallergenic variant of Der p 1 as a candidate for mite allergy vaccines.
Hypersensitivity
A new method, distribution-analyzing latex immunoassay (DALIA), to measure specific immunoglobulin G against mite and wheat allergen in human sera.
Hypersensitivity
A prospective safety-monitoring study of immunotherapy in mite-allergy patients with mass-units-standardized extract.
Hypersensitivity
A recombinant group 1 house dust mite allergen, rDer f 1, with biological activities similar to those of the native allergen.
Hypersensitivity
Absence of immunoglobulin E synthesis and airway eosinophilia by vaccination with plasmid DNA encoding ProDer p 1.
Hypersensitivity
Activation of mas-related G-protein coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation.
Hypersensitivity
Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays.
Hypersensitivity
Acute and Subacute Oral Toxicity of Deoxynivalenol Exposure in a Dermatophagoides farinae-Induced Murine Asthma Model.
Hypersensitivity
Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens.
Hypersensitivity
Analysis of predicted B and T-cell epitopes in Der p 23, allergen from Dermatophagoides pteronyssinus.
Hypersensitivity
Asthma and allergic symptoms in relation to house dust endotoxin: Phase Two of the International Study on Asthma and Allergies in Childhood (ISAAC II).
Hypersensitivity
Asthma, Airway Symptoms and Rhinitis in Office Workers in Malaysia: Associations with House Dust Mite (HDM) Allergy, Cat Allergy and Levels of House Dust Mite Allergens in Office Dust.
Hypersensitivity
Bioavailability of House Dust Mite Allergens in Sublingual Allergy Tablets Is Highly Dependent on the Formulation.
Hypersensitivity
Biochemical and immunological characterization of a recombinant precursor form of the house dust mite allergen Der p 1 produced by Drosophila cells.
Hypersensitivity
Can atopy patch tests with aeroallergens be an additional diagnostic criterion for atopic dermatitis?
Hypersensitivity
Cockroach sensitization mitigates allergic rhinoconjunctivitis symptom severity in patients allergic to house dust mites and pollen.
Hypersensitivity
Comparative enzymology of native and recombinant house dust mite allergen Der p 1.
Hypersensitivity
Comparative modelling of major house dust mite allergen Der p I: structure validation using an extended environmental amino acid propensity table.
Hypersensitivity
Comparison of the Allergenic Potency of House Dust Extract and House Dust Mite Allergen Extract for Subcutaneous Allergen Immunotherapy.
Hypersensitivity
Component-resolved diagnosis with commercially available d. Pteronyssinus der p 1, der p 2, and der p 10: relevant markers for house dust mite allergy.
Hypersensitivity
Cutaneous hypersensitivity reactions to Psoroptes ovis and Der p 1 in sheep previously infested with P. ovis--the sheep scab mite.
Hypersensitivity
Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: biochemical skin barrier against mite cysteine proteases.
Hypersensitivity
Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells.
Hypersensitivity
Der p 1 and Der p 2 specific immunoglobulin E measurement for diagnosis of Dermatophagoides pteronyssinus allergy: A systematic review and meta-analysis.
Hypersensitivity
Der p 1 IgE measurement for distinguishing between sensitization and allergy.
Hypersensitivity
Designing an epitope vaccine against Dermatophagoides pteronyssinus: An in silico study.
Hypersensitivity
Diagnostic significance of in vitro T-cell proliferative responses to house-dust mite Der p 1 in children with dust-mite allergy.
Hypersensitivity
Distinctive immunoglobulin E anti-house dust allergen-binding specificities in a tropical Australian Aboriginal community.
Hypersensitivity
Dust mite allergen, glutathione S-transferase, induces T cell immunoglobulin mucin domain-4 in dendritic cells to facilitate initiation of airway allergy.
Hypersensitivity
Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations.
Hypersensitivity
Dust mite species and allergen concentrations in beds of individuals belonging to different urban socioeconomic groups in Brazil.
Hypersensitivity
Early oral exposure to house dust mite allergen through breast milk: a potential risk factor for allergic sensitization and respiratory allergies in children.
Hypersensitivity
Effect of diesel on chemokines and chemokine receptors involved in helper T cell type 1/type 2 recruitment in patients with asthma.
Hypersensitivity
Effects of oral hyposensitization with recombinant Der f2 on immediate airway constriction in a murine allergic model.
Hypersensitivity
Eliminating Dermatophagoides farinae spp. (Acari: Pyroglyphidae) and their allergens through high temperature treatment of textiles.
Hypersensitivity
Evaluation and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens using a new multiplex assay: a real-life experience on an Italian population.
Hypersensitivity
Evaluation of the Role of IgE Responses to Der p 1 and Der p 2 in Chinese House Dust Mite-Allergic Patients.
Hypersensitivity
Evidence of the efficacy and safety of house dust mite subcutaneous immunotherapy in elderly allergic rhinitis patients: a randomized, double-blind placebo-controlled trial.
Hypersensitivity
Exposure to a high concentration of mite allergen in early infancy is a risk factor for developing atopic dermatitis: a 3-year follow-up study.
Hypersensitivity
Expression and immunogenicity of the major house dust mite allergen Der p 1 following DNA immunization.
Hypersensitivity
Expression cloning of a dust mite cysteine proteinase, Der p1, a major allergen associated with asthma and hypersensitivity reactions.
Hypersensitivity
Family history, dust mite exposure in early childhood, and risk for pediatric atopy and asthma.
Hypersensitivity
Generation of a transgenic rice seed-based edible vaccine against house dust mite allergy.
Hypersensitivity
Genetically engineered Lactococcus lactis protect against house dust mite allergy in a BALB/c mouse model.
Hypersensitivity
Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der f 1 decelerates the speed of maturation.
Hypersensitivity
High-efficiency vacuum cleaners increase personal mite allergen exposure, but only slightly.
Hypersensitivity
High-level expression of recombinant house dust mite allergen Der p 1 in Pichia pastoris.
Hypersensitivity
Highly sensitive and specific ELISA with monoclonal antibody capture to measure Dermatophagoides farinae 1-specific IgE.
Hypersensitivity
House dust mite allergen reduction and allergy at 4 yr: follow up of the PIAMA-study.
Hypersensitivity
House dust mite major allergen Der f 1 enhances proinflammatory cytokine and chemokine gene expression in a cell line of canine epidermal keratinocytes.
Hypersensitivity
House Dust Mite Sublingual Immunotherapy for Pediatric Patients With Allergic Asthma.
Hypersensitivity
Human T cell subset commitment determined by the intrinsic property of antigen: the proteolytic activity of the major mite allergen Der p 1 conditions T cells to produce more IL-4 and less IFN-gamma.
Hypersensitivity
Identifying Potential Co-Sensitization and Cross-Reactivity Patterns Based on Component-Resolved Diagnosis.
Hypersensitivity
IgE Abs to Der p 1 and Der p 2 as diagnostic markers of house dust mite allergy as defined by a bronchoprovocation test.
Hypersensitivity
IgE Epitopes of the House Dust Mite Allergen Der p 7 Are Mainly Discontinuous and Conformational.
Hypersensitivity
Immune reactivity to Der p I and Der p II in house dust mite sensitive patients attending paediatric and adult allergy clinics.
Hypersensitivity
Immunomodulatory properties of Lactobacillus plantarum and its use as a recombinant vaccine against mite allergy.
Hypersensitivity
Immunotoxicity of organophosphate flame retardants TPHP and TDCIPP on murine dendritic cells in vitro.
Hypersensitivity
Importance of house dust mite and Alternaria allergens in childhood asthma: an epidemiological study in two climatic regions of Australia.
Hypersensitivity
Induction of allergic reactions in guinea pigs with purified house dust mite allergens.
Hypersensitivity
Inhibition of mucosal and systemic T(h)2-type immune responses by intranasal peptides containing a dominant T cell epitope of the allergen Der p 1.
Hypersensitivity
Involvement of the mannose receptor in the uptake of Der p 1, a major mite allergen, by human dendritic cells.
Hypersensitivity
Lipophilic Allergens, Different Modes of Allergen-Lipid Interaction and Their Impact on Asthma and Allergy.
Hypersensitivity
Lymphocyte responsiveness to Dermatophagoides farinae extract in mite-sensitive patients: effect of immunotherapy on cellular proliferative response and specific immunoglobulin E antibody (RAST score).
Hypersensitivity
Manchester Asthma and Allergy Study: low-allergen environment can be achieved and maintained during pregnancy and in early life.
Hypersensitivity
Mattress encasings and mite allergen levels in the Prevention and Incidence of Asthma and Mite Allergy study.
Hypersensitivity
Meta-Transcriptomic Analysis Reveals the Virome and Viral Genomic Evolution of Medically Important Mites.
Hypersensitivity
Mite and pet allergen levels in homes of children born to allergic and nonallergic parents: the PIAMA study.
Hypersensitivity
Mite hypersensitivity in patients with rhinitis and rhinosinusitis living in a tropical environment.
Hypersensitivity
Molecular diagnosis in house dust mite allergic patients suggests clinical relevance of Der p 23 in asthmatic children.
Hypersensitivity
Monthly variation of Dermatophagoides allergens and its influence on respiratory allergy in a high altitude environment (Quito, 2800ma.s.l. in Andean Ecuador).
Hypersensitivity
Primary sequence and molecular model of the variable region of a mouse monoclonal anti-Der p 1 antibody showing a similar epitope specificity as human IgE.
Hypersensitivity
Probiotic E. coli Nissle 1917 activates DC and prevents house dust mite allergy through a TLR4-dependent pathway.
Hypersensitivity
Profiles of IgE Sensitization to Der f 1, Der f 2, Der f 6, Der f 8, Der f 10, and Der f 20 in Korean House Dust Mite Allergy Patients.
Hypersensitivity
Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1.
Hypersensitivity
Protective effect of the DNA vaccine encoding the major house dust mite allergens on allergic inflammation in the murine model of house dust mite allergy.
Hypersensitivity
Purified Der p1 and p2 patch tests in patients with atopic dermatitis: evidence for both allergenicity and proteolytic irritancy.
Hypersensitivity
Randomized double-blind placebo-controlled trial of sublingual immunotherapy in children with house dust mite allergy in primary care: study design and recruitment.
Hypersensitivity
Reaginic bronchial allergy and the occurrence of reagins against mites in a representative sample of a local Swedish population.
Hypersensitivity
Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25 and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice.
Hypersensitivity
Recombinant Fusion Proteins Assembling Der p 1 and Der p 2 Allergens from Dermatophagoides pteronyssinus.
Hypersensitivity
Relationship between allergic status and specificity of IgG antibody to inhaled allergens: the grass pollen model.
Hypersensitivity
Relationship between Dermatophagoides mite density and specific immune response in asthmatic patients.
Hypersensitivity
Results of a field study on the influence of HygienicWood mattress toppers on the number of mites in bed dust and the state of health of people with house dust mite allergies.
Hypersensitivity
Safety of cluster specific immunotherapy with a modified high-dose house dust mite extract.
Hypersensitivity
Seasonal variation in airway hyperresponsiveness and natural exposure to house dust mite allergens in patients with asthma.
Hypersensitivity
Sensitization to Dermatophagoides pteronyssinus and Blomia tropicalis extracts and recombinant mite allergens in atopic Thai patients.
Hypersensitivity
Sensitization to storage mites in house dust mite (Dermatophagoides pteronyssinus) allergic patients. Comparison of a rural and an urban population.
Hypersensitivity
Sensitization to the storage mite Tyrophagus putrescentiae in urban population of Upper Silesia (Poland).
Hypersensitivity
Sick building syndrome (SBS) among office workers in a Malaysian university--Associations with atopy, fractional exhaled nitric oxide (FeNO) and the office environment.
Hypersensitivity
Suppression of allergic airway inflammation by helminth-induced regulatory T cells.
Hypersensitivity
T cell cytokine responses to outer membrane proteins of Haemophilus influenzae and the house dust mite allergens Der p 1 in allergic and non-allergic subjects.
Hypersensitivity
Th2 polarization by Der p 1--pulsed monocyte-derived dendritic cells is due to the allergic status of the donors.
Hypersensitivity
The air pollutant sodium sulfite enhances mite crude extract-stimulated detachment of A549 airway epithelium cells.
Hypersensitivity
The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response.
Hypersensitivity
The Melbourne house dust mite study: eliminating house dust mites in the domestic environment.
Hypersensitivity
The novel high molecular weight Dermatophagoides farinae protein Zen-1 is a major allergen in North American and European mite allergic dogs with atopic dermatitis.
Hypersensitivity
The Role of Der p 23 Sensitization: An Analysis of 474 Patients Sensitized to Mite.
Hypersensitivity
The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins.
Hypersensitivity
Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen.
Hypersensitivity
Vaccination with the recombinant allergen ProDer p 1 complexed with the cationic lipid DiC14-amidine prevents allergic responses to house dust mite.
Hypersensitivity
Variability of IgE reactivity profiles among European mite allergic patients.
Hypersensitivity
Vbeta18.1(+) and V(alpha)2.3(+) T-cell subsets are associated with house dust mite allergy in human subjects.
Hypersensitivity
Whole Transcriptome Analysis of Myeloid Dendritic Cells Reveals Distinct Genetic Regulation in Patients with Allergies.
Hypersensitivity
[Effect of a mite-killing agent on house dust and on symptoms of house dust allergy]
Hypersensitivity
[Evaluation of sensitization to Der p 1 and Der p 2 in a pediatric population of the North of Portugal].
Hypersensitivity
[Exposure and allergy to dust mites in general and working environment in Croatia]
Hypersensitivity
[House dust mite allergens and mite allergy in Copenhagen dwellings. A cross-sectional study]
Hypersensitivity
[Preparation and evaluation of mouse model of house dust mite-induced asthma]
Hypersensitivity, Delayed
Hypersensitivity reactions after respiratory sensitization: effect of intranasal peptides containing T-cell epitopes.
IgA Deficiency
Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1.
Infections
A Toxocara canis infection influences the immune response to house dust mite allergens in dogs.
Infections
Antibody and cytokine responses to house dust mite allergens and Toxoplasma gondii antigens in atopic and non-atopic Brazilian subjects.
Infections
Aspergillus fumigatus synergistically enhances mite-induced allergic airway inflammation.
Infections
Differential cytokine mRNA expression in Dermatophagoides farinae allergen-sensitized and respiratory syncytial virus-infected mice.
Infections
Effect of helminthic infections together with mite allergen exposure on the risk of wheeze in preschool children.
Infections
Effects of respiratory syncytial virus infection on dendritic cells and cysteinyl leukotrienes in lung tissues of a murine model of asthma.
Infections
House dust mite Der p 1 downregulates defenses of the lung by inactivating elastase inhibitors.
Infections
Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1.
Infections
Respiratory syncytial virus infection and virus-induced inflammation are modified by contaminants of indoor air.
Infections
Rhinovirus Infection Promotes Eosinophilic Airway Inflammation after Prior Exposure to House Dust Mite Allergen.
Infections
Severity of Allergic Airway Disease Due to House Dust Mite Allergen Is Not Increased after Clinical Recovery of Lung Infection with Chlamydia pneumoniae in Mice.
Infections
Tumor necrosis factor family member LIGHT acts with IL-1? and TGF-? to promote airway remodeling during rhinovirus infection.
Influenza, Human
Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation.
Laryngitis
Soot and house dust mite allergen cause eosinophilic laryngitis in an animal model.
Lung Neoplasms
A different profile of epitopic dominance in the immunoglobulin G response to bovine betalactoglobulin in lung cancer.
Lung Neoplasms
Lung cancer-related changing profile of B-cell epitopes recognized on mucosal antigens: the Der p1 model.
Milk Hypersensitivity
Early sensitisation and development of allergic airway disease - risk factors and predictors.
Mite Infestations
Cross-reactivity between the house dust mite Dermatophagoides pteronyssinus and the mange mites Psoroptes cuniculi and P. ovis. I. Demonstration of antibodies to the house dust mite allergen Dpt 12 in sera from P. cuniculi-infested rabbits.
Nasal Polyps
The effect of nano-silver on the activation of nasal polyp epithelial cells by Alternaria, Der P1 and staphylococcal enterotoxin B.
Neoplasms
?-catenin mediates the inflammatory cytokine expression induced by the Der p 1 house dust mite allergen.
Neoplasms
A different profile of epitopic dominance in the immunoglobulin G response to bovine betalactoglobulin in lung cancer.
Neoplasms
Effects of astragaloside IV on eosinophil activation induced by house dust mite allergen.
Neoplasms
House dust mite allergen Der p 1 elevates the release of inflammatory cytokines and expression of adhesion molecules in co-culture of human eosinophils and bronchial epithelial cells.
Neoplasms
Immunotherapy suppresses both Th1 and Th2 responses by allergen stimulation, but suppression of the Th2 response is a more important mechanism related to the clinical efficacy of immunotherapy for perennial allergic rhinitis.
Neoplasms
Severe atopic dermatitis is associated with a reduced frequency of IL-10 producing allergen-specific CD4+ T cells.
Neoplasms
Synergistic effect of diesel organic extracts and allergen Der p 1 on the release of chemokines by peripheral blood mononuclear cells from allergic subjects: involvement of the map kinase pathway.
Neurogenic Inflammation
Mite allergen induces allergic dermatitis with concomitant neurogenic inflammation in mouse.
Niemann-Pick Diseases
Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition.
Overweight
[An analysis of skin prick test reactivity to dust mite in overweight and normal weight children with allergic asthma before and after specific immunotherapy].
Pneumonia
Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)-induced epithelial cytokine release through aryl hydrocarbon receptor in asthma.
Pneumonia
FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation.
Pneumonia
Hypersensitivity reactions after respiratory sensitization: effect of intranasal peptides containing T-cell epitopes.
Pneumonia
Interaction of air pollutants and pulmonary allergic responses in experimental animals.
Pneumonia
Lipopolysaccharide inhibits th2 lung inflammation induced by house dust mite allergens in mice.
Pneumonia
Transgenic mice expressing the T cell antigen receptor specific for an immunodominant epitope of a major allergen of house dust mite develop an asthmatic phenotype on exposure of the airways to allergen.
Pruritus
Costello syndrome model mice with a HrasG12S/+ mutation are susceptible to develop house dust mite-induced atopic dermatitis.
Pruritus
Effect of mattress encasings on atopic dermatitis outcome measures in a double-blind, placebo-controlled study: the Dutch mite avoidance study.
Pruritus
[Atopic dermatitis and psoriasis: what is the benefit of in-patient high altitude climate therapy?]
Pulmonary Disease, Chronic Obstructive
[House dust mite allergens and COPD in children; a case-control study]
Respiratory Hypersensitivity
Benzo(a)pyrene Enhanced Dermatophagoides Group 1 (Der f 1)-Induced TGF?1 Signaling Activation Through the Aryl Hydrocarbon Receptor-RhoA Axis in Asthma.
Respiratory Hypersensitivity
Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)-induced epithelial cytokine release through aryl hydrocarbon receptor in asthma.
Respiratory Hypersensitivity
Lung microbiota promotes tolerance to allergens in neonates via PD-L1.
Rhinitis
A double blind, placebo-controlled cross over trial of cellulose powder by nasal provocation with Der p1 and Der f1.
Rhinitis
A subclass IgG4-specific antigen-binding radioimmunoassay (RIA): comparison between IgG and IgG4 antibodies to food and inhaled antigens in adult atopic dermatitis after desensitization treatment and during development of antibody responses in children.
Rhinitis
A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen.
Rhinitis
Allergenic differences between the domestic mites Blomia tropicalis and Dermatophagoides pteronyssinus.
Rhinitis
Asthma, Airway Symptoms and Rhinitis in Office Workers in Malaysia: Associations with House Dust Mite (HDM) Allergy, Cat Allergy and Levels of House Dust Mite Allergens in Office Dust.
Rhinitis
Atypical nasal challenges in patients with idiopathic rhinitis: more evidence for the existence of allergy in the absence of atopy?
Rhinitis
Component-resolved diagnosis with commercially available d. Pteronyssinus der p 1, der p 2, and der p 10: relevant markers for house dust mite allergy.
Rhinitis
Component-Resolved Diagnostic Study of Dermatophagoides Pteronyssinus Major Allergen Molecules in a Southern Chinese Cohort.
Rhinitis
Evaluation and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens using a new multiplex assay: a real-life experience on an Italian population.
Rhinitis
Exposure to indoor allergens in homes of patients with asthma and/or rhinitis in southeast Brazil: effect of mattress and pillow covers on mite allergen levels.
Rhinitis
Gender differences in indoor allergen exposure and association with current rhinitis.
Rhinitis
Homology modeling and prediction of B?cell and T?cell epitopes of the house dust mite allergen Der f 20.
Rhinitis
In planta expression of a mature Der p 1 allergen isolated from an Italian strain of Dermatophagoides pteronyssinus.
Rhinitis
Mite-specific immunotherapy using allergen and/or bacterial extracts in atopic patients in Brazil.
Rhinitis
Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study.
Rhinitis
Purification and characterization of a 94 KD high molecular weight allergen from house dust mite, Dermatophagoides pteronyssinus.
Rhinitis
Reactivity to recombinant house-dust-mite allergens in asthma and rhinitis in a tropical environment.
Rhinitis
Sensitization profiles of Malaysian and Singaporean subjects to allergens from Dermatophagoides pteronyssinus and Blomia tropicalis.
Rhinitis
Sublingual immunotherapy not effective in house dust mite-allergic children in primary care.
Rhinitis
Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen.
Rhinitis
Use of a chimeric ELISA to investigate immunoglobulin E antibody responses to Der p 1 and Der p 2 in mite-allergic patients with asthma, wheezing and/or rhinitis.
Rhinitis
Variation in the association OF Der p 1 and Der f 1 with asthma and rhinitis in 9-11 years old schoolchildren: The french six cities study.
Rhinitis
[Safety analysis of dust mite allergen for diagnosis and immunotherapy of asthma and rhinitis]
Rhinitis, Allergic
Activation of mas-related G-protein coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation.
Rhinitis, Allergic
Allergen binding to specific IgE in the nasal mucosa of allergic patients.
Rhinitis, Allergic
Assessing the efficacy of a novel temperature and humidity control machine to minimize house dust mite allergen exposure and clinical symptoms in allergic rhinitis children sensitized to dust mites: a pilot study.
Rhinitis, Allergic
Characteristics and management of sublingual allergen immunotherapy in children with allergic rhinitis and asthma induced by house dust mite allergens.
Rhinitis, Allergic
Comparison of indoor allergens, allergic scores, and demographic data in Taiwanese adults with asthma or allergic rhinitis, or both.
Rhinitis, Allergic
Dendritic cells modified with Der p1 antigen as a therapeutic potential for allergic rhinitis in a murine model via regulatory effects on IL-4, IL-10 and IL-13.
Rhinitis, Allergic
Effect of sublingual immunotherapy on platelet activity in children with allergic rhinitis.
Rhinitis, Allergic
Efficacy and safety of sublingual tablets of house dust mite allergen extracts in adults with allergic rhinitis.
Rhinitis, Allergic
Evidence of the efficacy and safety of house dust mite subcutaneous immunotherapy in elderly allergic rhinitis patients: a randomized, double-blind placebo-controlled trial.
Rhinitis, Allergic
Expression and refolding of mite allergen pro-Der f1 from inclusion bodies in Escherichia coli.
Rhinitis, Allergic
House dust mite allergen levels in households and correlation with allergic rhinitis symptoms.
Rhinitis, Allergic
House Dust Mite Sublingual Immunotherapy for Pediatric Patients With Allergic Asthma.
Rhinitis, Allergic
House dust mite sublingual-swallow immunotherapy in perennial rhinitis: a double-blind, placebo-controlled Iranian study.
Rhinitis, Allergic
Immunotherapy suppresses both Th1 and Th2 responses by allergen stimulation, but suppression of the Th2 response is a more important mechanism related to the clinical efficacy of immunotherapy for perennial allergic rhinitis.
Rhinitis, Allergic
Induction of IL-6 and IL-8 by house dust mite allergen Der p1 in cultured human nasal epithelial cells is associated with PAR/PI3K/NFkappaB signaling.
Rhinitis, Allergic
Interleukin-6 and interleukin-1 alpha production is associated with antigen-induced late nasal response.
Rhinitis, Allergic
Intranasal immunization with DNA vaccine coexpressing Der p 1 and ubiquitin in an allergic rhinitis mouse model.
Rhinitis, Allergic
Mite and cockroach allergens activate protease-activated receptor 2 and delay epidermal permeability barrier recovery.
Rhinitis, Allergic
Orchestration of an uncommon maturation cascade of the house dust mite protease allergen quartet.
Rhinitis, Allergic
Prevalence of sensitivity to cockroach allergens and IgE cross-reactivity between cockroach and house dust mite allergens in Chinese patients with allergic rhinitis and asthma.
Rhinitis, Allergic
Randomized double-blind placebo-controlled trial of sublingual immunotherapy in children with house dust mite allergy in primary care: study design and recruitment.
Rhinitis, Allergic
Regulation of constitutive neutrophil apoptosis due to house dust mite allergen in normal and allergic rhinitis subjects.
Rhinitis, Allergic
Relationship between active and passive smoking and total serum IgE levels in Japanese women: baseline data from the Osaka Maternal and Child Health Study.
Rhinitis, Allergic
Safety of semi-depot house dust mite allergen extract in children and adolescents with allergic rhinitis and asthma.
Rhinitis, Allergic
Semi-depot house-dust mite allergen extract for Chinese with allergic rhinitis and asthma.
Rhinitis, Allergic
Sensitization profile in patients with respiratory allergic diseases: differences between conventional and molecular diagnosis (a cross-sectional study).
Rhinitis, Allergic
Soy, isoflavones, and prevalence of allergic rhinitis in Japanese women: the Osaka Maternal and Child Health Study.
Rhinitis, Allergic
Strain-Specific Differences in House Dust Mite (Dermatophagoides farinae)-Induced Mouse Models of Allergic Rhinitis.
Rhinitis, Allergic
The herbal medicine shoseiryu-to inhibits allergen-induced synthesis of tumour necrosis factor alpha by peripheral blood mononuclear cells in patients with perennial allergic rhinitis.
Rhinitis, Allergic
[Clinical investigation of basophil activation test as a complementary test for house dust mite allergen].
Rhinitis, Allergic
[Clinical observation of the adverse effects of standardized dust mite allergen preparation in the treatment of allergic rhinitis].
Rhinitis, Allergic
[Efficacy evaluation of specific immunotherapy with standardized house dust mite allergen preparation for allergic rhinitis].
Rhinitis, Allergic
[Efficacy evaluation of standardized dust mite allergen specific immunotherapy to patients of allergic rhinitis].
Rhinitis, Allergic
[Experimental study on dendritic cells modified by dust mite allergen gene in the treatment of allergic rhinitis in mouse].
Rhinitis, Allergic
[Intradermal immunotherapy with low-dose house dust mite allergens in patients with allergic rhinitis: A proof-of-concept study].
Rhinitis, Allergic
[Research on the efficacy and mechanism of standardized house dust mite allergen vaccine to allergic rhinitis].
Rhinitis, Allergic
[The relationship between the density of house dust mite allergens in bedroom and the attacks of allergic rhinitis]
Rhinitis, Allergic, Seasonal
Allergen binding to specific IgE in the nasal mucosa of allergic patients.
Rhinitis, Allergic, Seasonal
Current eczema in children is related to Der f 1 exposure but not to Der p 1 exposure.
Rhinitis, Allergic, Seasonal
Immunotherapy with monomethoxypolyethylene glycol modified allergens.
Rhinitis, Allergic, Seasonal
Principal components analysis of atopy-related traits in a random sample of children.
Scabies
Increased allergic immune response to Sarcoptes scabiei antigens in crusted versus ordinary scabies.
Sick Building Syndrome
Relationships between mite allergen levels, mold concentrations, and sick building syndrome symptoms in newly built dwellings in Japan.
Sick Building Syndrome
[Variations of indoor environment and the prevalence of sick house syndrome over three-year period in detached houses in Sapporo].
Sleep Initiation and Maintenance Disorders
Effect of mattress encasings on atopic dermatitis outcome measures in a double-blind, placebo-controlled study: the Dutch mite avoidance study.
Tetanus
Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma.
Tetanus
Lymphoproliferative responses in cord blood and at one year: no evidence for the effect of in utero exposure to dust mite allergens.
Tetanus
The house dust mite allergen, Dermatophagoides pteronyssinus, promotes type 2 responses by modulating the balance between IL-4 and IFN-gamma.
Tuberculosis
An annexin 1 (ANXA1)-derived peptide inhibits prototype antigen-driven human T cell Th1 and Th2 responses in vitro.
Urticaria
Exposure to a high concentration of mite allergen in early infancy is a risk factor for developing atopic dermatitis: a 3-year follow-up study.
Urticaria
[Urticaria in relation to mite sensitivity and immunotherapy with Injectio dermatophagoidei farinae]
Whooping Cough
Repeated episodes of ozone inhalation amplifies the effects of allergen sensitization and inhalation on airway immune and structural development in Rhesus monkeys.
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
additional information
the Group 7 as well as the Group 2 mite allergens are structurally similar to different proteins in the TLR pathway
physiological function
Der p 7 elicits strong IgE antibody and T-cell responses in mite allergic patients. Sensitization to house dust mite allergens is strongly correlated with asthma. The allergen function may contribute to allergenicity, e.g. the protease activity of Group 1 mite allergens, and the interaction with the innate immune system by Group 2 mite allergens
physiological function
the isozymes have allergenic potential in humans
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). ALL7_DERPT
215
0
23881
Swiss-Prot
other Location (Reliability: 2)
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
22200
x * 22200, about, mature Der p 7, sequence calculation, x * 24000-31000, SDS-PAGE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
x * 22200, about, mature Der p 7, sequence calculation, x * 24000-31000, SDS-PAGE
additional information
Der p 7 has an elongated structure with two 4-stranded anti-parallel beta-sheets which wrap around a long C-terminal helix, NMR analysis of His-tagged Der p 7, overview
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
glycoprotein
different levels of glycosylation or isozymes
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant Der p 7-MBP fusion protein, mixing of 0.001 ml of 27 mg/mL protein in 25 mM HEPES, pH 7.4, 75 mM NaCl, and 5 mM maltose, with 00.001 ml of reservoir solution containing 42.5 mM Tris pH 8.5, 12.75% PEG 4000, 85 mM lithium sulfate, and 7.5% glycerol, 4°C, 1 week, X-ray diffraction structure determination and analysis at 2.35 A resolution, molecular replacement
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
C132V
site-directed mutagenesis, Der p 1 catalytic site mutant
additional information
additional information
development of chimeras assembling Der p 1 and Der p 2 allergens. Mutations in the Der p 1 catalytic site are also engineered
additional information
-
development of chimeras assembling Der p 1 and Der p 2 allergens. Mutations in the Der p 1 catalytic site are also engineered
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant Der p 7-MBP fusion protein Der p 7 from Escherichia coli Rosetta2(DE3) pLacI cells by amylose affinity chromatography and gel filtration. Recombinant His6-tagged Der p 7 from Escherichia coli Rosetta2(DE3) pLacI cells by alternating nickel affinity and anion exchange chromatography
recombinant His-tagged fusion proteins by nickel affinity chromatography using a His-Trap column under denaturing conditions with 20 m M sodium phosphate, pH 7.0, 0.5 M NaCl, 0.05% Tween 20, 8 M urea, 1 mM DTT, 0.03 M imidazole as binding buffer, and 20 mM sodium phosphate, pH 7.8, 0.05% Tween 20, 8 M urea, 1 mM DTT, 1 M imidazole as elution buffer
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of Der p 7-MBP fusion protein and His6-tagged Der p 7 in Escherichia coli Rosetta2(DE3) pLacI cells
expression of His-tagged fusion proteins encompassing Der p 2 with either mature or proDer p 1 in Escherichia coli strain BL21 (DE3) and Origami2 (DE3), or in Pichia pastoris strain GS115 or X33. Four fusion proteins are expressed in Escherichia coli as inclusion bodies, whereas only chimeras comprising proDer p 1 are obtained in yeast
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RENATURED/Commentary
ORGANISM
UNIPROT
LITERATURE
recombinant His-tagged fusion proteins encompassing Der p 2 with either mature or proDer p 1 from Escherichia coli inclusion bodies with purification via denaturating nickel affinity chromatography
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
chimeras assembling Der p 1 and Der p 2 allergens are potential candidate vaccines against house dust mite allergy. But significant solubility and stability issues can limit the application of such chimeras for immunotherapy or diagnostic
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bussieres, L.; Bordas-Le Floch, V.; Bulder, I.; Chabre, H.; Nony, E.; Lautrette, A.; Berrouet, C.; Nguefeu, Y.; Horiot, S.; Baron-Bodo, V.; Van Overtvelt, L.; De Conti, A.M.; Schlegel, A.; Maguet, N.; Mouz, N.; Lemoine, P.; Batard, T.; Moingeon, P.
Recombinant fusion proteins assembling Der p 1 and Der p 2 allergens from Dermatophagoides pteronyssinus
Int. Arch. Allergy Immunol.
153
141-151
2010
Dermatophagoides pteronyssinus (P49273), Dermatophagoides pteronyssinus
brenda
Mueller, G.A.; Edwards, L.L.; Aloor, J.J.; Fessler, M.B.; Glesner, J.; Pomes, A.; Chapman, M.D.; London, R.E.; Pedersen, L.C.
The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins
J. Allergy Clin. Immunol.
125
909-917.e4
2010
Dermatophagoides pteronyssinus (P49273)
brenda
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