Information on EC 3.4.22.64 - caspase-11

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The expected taxonomic range for this enzyme is: Euarchontoglires

EC NUMBER
COMMENTARY
3.4.22.64
-
RECOMMENDED NAME
GeneOntology No.
caspase-11
-
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp-/-
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of peptide bond
-
-
-
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
C14.012
-
-
-
-
caspase 11
-
-
caspase-11
-
cf 3.4.22.57
caspase-11
P70343
-
caspase-11
Q91XW7
-
caspase-4
-
-
ICH-3 protease
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
216503-96-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
C57BL, wild type and p53KO mice
-
-
Manually annotated by BRENDA team
gene Casp11
-
-
Manually annotated by BRENDA team
strain C3H/An
SwissProt
Manually annotated by BRENDA team
strain C57BL/6 X CBA
SwissProt
Manually annotated by BRENDA team
Mus musculus C3H/An
strain C3H/An
SwissProt
Manually annotated by BRENDA team
Mus musculus C57BL/6 X CBA
strain C57BL/6 X CBA
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
malfunction
-
germline mutation of Casp11 in mouse strain 129 abolishes inflammasome activation by CTB. Strain 129 mice, like Casp11-/- mice, exhibits defects in IL-1beta production and harbours a mutation in the Casp11 locus that attenuates caspase-11 expression
physiological function
-
caspase-11 mediates non-canonical inflammasome activation.Caspase-11 rather than caspase-1 is required for lipopolysaccharide-induced lethality. Interleukin-1beta secretion in response to other bacterial toxins, including adenylcyclase toxin, listeriolysin O toxin, or Clostridium difficile toxin B, is not affected by caspase-11 deficiency. Caspase-11 also is dispensable for NLRP3-dependent IL-1beta secretion in response to monosodium urate, calcium pyrophosphate, or the ionophore nigericin. In contrast, NLRP3- and ASC-dependent IL-1beta secretion from BMDMs infected with live Escherichia coli, Citrobacter rodentium and Vibriae cholerae, requires caspase-11, with or without lipopolysaccharide priming
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
procaspase-1 + H2O
?
show the reaction diagram
-
-, the enzyme is an upstream activator of caspase-1
-
-
?
procaspase-3 + H2O
?
show the reaction diagram
-
-, the enzyme is a critical initiator caspase responsible for the activation of caspase-3
-
-
?
acetyl-VEHD-7-amido-4-methylcoumarin + H2O
acetyl-VEHD + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
additional information
?
-
P70343
-
-
-
-
additional information
?
-
-
optimal cleavage site is IEHD, LEHD, VEHD or PEHD
-
-
-
additional information
?
-
-
overexpression induces apoptosis
-
-
-
additional information
?
-
-
phenotype of animals deficient in caspase-11: resistant to lipopolysaccharide-induced caspase-1 processing, interleukin-1alpha and interleukin-beta secretion, and endotoxic shock
-
-
-
additional information
?
-
-
the enzyme is a critical initiator caspase responsible for the activation of caspase-3. The enzyme is an upstream activator of caspase-1. Caspase-11 deficient animals have a reduced number of apoptotic cells and a defect in caspase-3 activation after middle cerebral artery occlusion. The enzyme is A VERY IMPORTANT REGULATOR OF APOPTOSIS
-
-
-
additional information
?
-
-
enzyme is involved in cytokine activation
-
-
-
additional information
?
-
-
pro-caspase-11 physically interacts with pro-ICE in cells, the expression of casp-11 is essential for activation of ICE. Caspase-11 is a compinent of ICE complex and is required for the activation of ICE. Important role of ICE and caspase-11 in mediating apoptosis in pathological conditions
-
-
-
additional information
?
-
P70343
the enzyme may play a very important role in apoptosis and inflammatory responses and may be an upstream regulator of ICE
-
-
-
additional information
?
-
-
the enzyme is involved in cytokine activation
-
-
-
additional information
?
-
-
C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation
-
-
-
additional information
?
-
-
caspase-11 has a regulatory role in ethanol-induced apoptosis. Suppression of caspase-11 expression may be a mechanism by which Scutellariae radix (Chinese herbal medicine) exerts its cytoprotective effect
-
-
-
additional information
?
-
Q91XW7
caspase-11 plays a crucial role in both inflammation and apoptosis. Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin (IL)-1 and IL-18, but also activates caspase-3, leading to cellular apoptosis under pathological conditions. The expression of caspase-11 is strongly induced at both mRNA and protein levels by inflammatory stimuli such as lipopolysaccharide, interferon-Q Q, and tumor necrosis factor-K K in C6 rat glial cells as well as primary astrocytes. Induction of caspase-11 by LPS in astrocytes is mediated through the p38 MAPK pathway. Inflammatory induction of caspase-11 in astrocytes may play an important role in both inflammatory responses involving these cells and auto-regulatory apoptosis of activated astrocytes in inflammatory sites
-
-
-
additional information
?
-
-
neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice
-
-
-
additional information
?
-
-
neurotoxicity of 1-methyl-4-pheny-1,2,3,6-tetrahydropyridine may be mediated via activation of the caspase-11 cascade and inflammatory cascade, as well as the mitochondrial apoptotic cascade
-
-
-
additional information
?
-
-
a pathway modulating inflammatory-cell migration involve caspase-11 and actin interacting protein 1
-
-
-
additional information
?
-
-
caspase-11 may be a central regulator of multiple events, including cell migration, cytokine maturation and apoptosis, during inflammation responses. Caspase-11 interacts physically and functionally with actin interacting protein 1, an activator of cofilin-mediated actin depolymerization. Caspase-11 and actin interacting protein 1 work cooperatively to promote cofilin-mediated actin depolymerization
-
-
-
additional information
?
-
-
Flightless-I regulates the subcellular distribution of caspase-11 by promoting its localization at the cell leading edge
-
-
-
additional information
?
-
Mus musculus C3H/An
P70343
-
-
-
-
additional information
?
-
Mus musculus C57BL/6 X CBA
P70343
the enzyme may play a very important role in apoptosis and inflammatory responses and may be an upstream regulator of ICE
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
procaspase-1 + H2O
?
show the reaction diagram
-
-
-
-
?
procaspase-3 + H2O
?
show the reaction diagram
-
the enzyme is a critical initiator caspase responsible for the activation of caspase-3
-
-
?
additional information
?
-
P70343
-
-
-
-
additional information
?
-
-
overexpression induces apoptosis
-
-
-
additional information
?
-
-
phenotype of animals deficient in caspase-11: resistant to lipopolysaccharide-induced caspase-1 processing, interleukin-1alpha and interleukin-beta secretion, and endotoxic shock
-
-
-
additional information
?
-
-
the enzyme is a critical initiator caspase responsible for the activation of caspase-3. The enzyme is an upstream activator of caspase-1. Caspase-11 deficient animals have a reduced number of apoptotic cells and a defect in caspase-3 activation after middle cerebral artery occlusion. The enzyme is A VERY IMPORTANT REGULATOR OF APOPTOSIS
-
-
-
additional information
?
-
-
enzyme is involved in cytokine activation
-
-
-
additional information
?
-
-
pro-caspase-11 physically interacts with pro-ICE in cells, the expression of casp-11 is essential for activation of ICE. Caspase-11 is a compinent of ICE complex and is required for the activation of ICE. Important role of ICE and caspase-11 in mediating apoptosis in pathological conditions
-
-
-
additional information
?
-
P70343
the enzyme may play a very important role in apoptosis and inflammatory responses and may be an upstream regulator of ICE
-
-
-
additional information
?
-
-
the enzyme is involved in cytokine activation
-
-
-
additional information
?
-
-
C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation
-
-
-
additional information
?
-
-
caspase-11 has a regulatory role in ethanol-induced apoptosis. Suppression of caspase-11 expression may be a mechanism by which Scutellariae radix (Chinese herbal medicine) exerts its cytoprotective effect
-
-
-
additional information
?
-
Q91XW7
caspase-11 plays a crucial role in both inflammation and apoptosis. Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin (IL)-1 and IL-18, but also activates caspase-3, leading to cellular apoptosis under pathological conditions. The expression of caspase-11 is strongly induced at both mRNA and protein levels by inflammatory stimuli such as lipopolysaccharide, interferon-Q Q, and tumor necrosis factor-K K in C6 rat glial cells as well as primary astrocytes. Induction of caspase-11 by LPS in astrocytes is mediated through the p38 MAPK pathway. Inflammatory induction of caspase-11 in astrocytes may play an important role in both inflammatory responses involving these cells and auto-regulatory apoptosis of activated astrocytes in inflammatory sites
-
-
-
additional information
?
-
-
neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice
-
-
-
additional information
?
-
-
neurotoxicity of 1-methyl-4-pheny-1,2,3,6-tetrahydropyridine may be mediated via activation of the caspase-11 cascade and inflammatory cascade, as well as the mitochondrial apoptotic cascade
-
-
-
additional information
?
-
-
a pathway modulating inflammatory-cell migration involve caspase-11 and actin interacting protein 1
-
-
-
additional information
?
-
-
caspase-11 may be a central regulator of multiple events, including cell migration, cytokine maturation and apoptosis, during inflammation responses. Caspase-11 interacts physically and functionally with actin interacting protein 1, an activator of cofilin-mediated actin depolymerization. Caspase-11 and actin interacting protein 1 work cooperatively to promote cofilin-mediated actin depolymerization
-
-
-
additional information
?
-
-
Flightless-I regulates the subcellular distribution of caspase-11 by promoting its localization at the cell leading edge
-
-
-
additional information
?
-
Mus musculus C3H/An
P70343
-
-
-
-
additional information
?
-
Mus musculus C57BL/6 X CBA
P70343
the enzyme may play a very important role in apoptosis and inflammatory responses and may be an upstream regulator of ICE
-
-
-
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
Z-LEHD-fluoromethylketone
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
additional information
-
benzene, increase of caspase-4 expression after 12 days of oral benzene treatment to p53KO mice
-
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
-
caspase-11 is upregulated in a subpopulation of cells i brain after ischemic injury
Manually annotated by BRENDA team
Mus musculus C3H/An
-
-
-
Manually annotated by BRENDA team
P70343
low activity
Manually annotated by BRENDA team
Mus musculus C3H/An
-
low activity
-
Manually annotated by BRENDA team
-
caspase-11-deficient leukocytes are defective in migration
Manually annotated by BRENDA team
P70343
low activity
Manually annotated by BRENDA team
Mus musculus C3H/An
-
low activity
-
Manually annotated by BRENDA team
-
bone marrow-derived
Manually annotated by BRENDA team
-
neuroblastoma cell
Manually annotated by BRENDA team
P70343
low activity
Manually annotated by BRENDA team
Mus musculus C3H/An
-
low activity
-
Manually annotated by BRENDA team
Mus musculus C3H/An
-
-
-
Manually annotated by BRENDA team
P70343
low activity
Manually annotated by BRENDA team
Mus musculus C57BL/6 X CBA
-
-
-
Manually annotated by BRENDA team
additional information
P70343
no activity detected in brain
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
additional information
-
Flightless-I regulates the subcellular distribution of caspase-11 by promoting its localization at the cell leading edge
-
Manually annotated by BRENDA team
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
proteolytic modification
-
procaspase-11 can autoprocess itself in vitro
Cloned/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
expression in Escherichia coli
-
overexpression in Rat-1 and HeLa cells induces apoptosis
P70343
EXPRESSION
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
poly(ADP-ribose) polymerase-1, PARP-1, regulates the expression of caspase-11 following lipopolysaccharide stimulation. PARP-1 is recruited to the caspase-11 promoter region containing predicted nuclear factor (NF)-kappaB-binding sites, but PARP-1 enzymatic activity is not required for the caspase-11 upregulation. PARP-1 can regulate the induction of caspase-11 at a transcriptional level. PARP-1 participates in the activation of caspase-11 promoter as a coactivator of NF-kappaB
-
induction of caspase-11 is dependent on NF-kappaB. PARP-1 participates in the activation of caspase-11 promoter as a coactivator of NF-kappaB. Lipopolysaccharide induce the enzyme expression
-
ischemia induces expression in astrocytes
-
ENGINEERING
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
-
targeting Casp11 exon 5 for deletion in C57BL/6 embryonic stem cells. Strain 129 mice, like Casp11-/- mutant mice, exhibits defects in IL-1beta production and harbours a mutation in the Casp11 locus that attenuates caspase-11 expression
APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
medicine
-
caspase-11 has a regulatory role in ethanol-induced apoptosis. Suppression of caspase-11 may be a mechanism by which Scutellariae radix (Chineses herbal medicine) exerts its cytoprotective effect