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Information on EC 3.4.22.61 - caspase-8
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3.4.22.61 caspase-8Specify your search results
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- 3.4.22.61
- caspase-9
- bcl-2
- necrosis
-
extrinsic
- bid
- tnf
-
trail
-
apoptosis-inducing
- parp
-
pro-apoptotic
-
anti-apoptotic
- leukemia
-
fas-associated
-
trail-induced
-
tunel
- fasl
-
annexin
-
death-inducing
-
factor-related
-
caspase-dependent
- c-flips
-
apoptosis-related
- xiap
-
fas-mediated
- flip
-
receptor-mediated
- nf-kappab
-
polyadp-ribose
-
jurkat
-
necroptosis
-
anti-fas
-
deoxynucleotidyl
- adp-ribose
-
pan-caspase
- z-vad-fmk
-
tnf-related
-
deltapsim
-
mitochondria-dependent
-
fas-induced
- survivin
-
receptor-induced
-
tnf-induced
-
receptor-interacting
- mlkl
-
mitochondria-mediated
- ripk1
-
sub-g1
- apaf-1
-
executioner
- drug development
- procaspase-3
- medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-/-(Gly/Ser/Ala)
Synonyms
caspase-8, caspase 8, casp8, flice, cysteine protease caspase-8, cysteine aspartic acid-specific protease, apoptotic cysteine protease, flice/mach, fadd-like ice, cysteine aspartic acid protease 8, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
caspase-8
-
apoptotic cysteine protease
-
-
-
-
apoptotic protease Mch-5
-
-
-
-
C14.004
-
-
-
-
CAP4
-
-
-
-
caspase 8
-
-
-
-
FADD-homologous ICE/CED-3-like protease
-
-
-
-
FADD-like ICE
-
-
-
-
FLICE
-
-
-
-
FLICE/MACH
-
-
-
-
ICE-like apoptotic protease 5
-
-
-
-
MACH
-
-
-
-
Mch5
-
-
-
-
MORT1-associated CED-3 homolog
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
-
-
-
-
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CAS REGISTRY NUMBER
COMMENTARY
179241-78-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Ac-IEPD-7-amido-4-methylcoumarin + H2O
Ac-IEPD + 7-amino-4-methylcoumarin
37°C
-
-
?
acetyl-IETD-7-amido-4-fluoromethylcoumarin + H2O
acetyl-IETD + 7-amino-4-fluoromethylcoumarin
-
-
-
?
acetyl-Ile-Glu-Thr-Asp-7-amino-4-fluoromethylcoumarin + H2O
Ac-IETD + 7-amino-4-fluoromethylcoumarin
37°C, pH 7.4
-
-
?
Bcl-2 protein Bid + H2O
?
cleavage results in a proapoptotic p15 tBid fragment
-
-
?
Ca2+/calmodulin-dependent protein kinase-like kinase + H2O
?
cleavage generates a 43 kDa C-terminal fragment and a small N-terminal fragment with proapoptotic activity
-
-
?
p21-activated kinase 2 + H2O
?
separates the N-terminal regulatory domain from the C-terminal catalytic domain
-
-
?
receptor-indicating protein + H2O
?
separates the N-terminal kinase from the C-terminal death domain
-
-
?
cellular inhibitor of apoptosis 1 + H2O
?
i.e. cIAP-1, TRAIL-induced degradation of cIAP-1 requires caspase 8 activity, and it is, at least in part, due to direct cleavage of cIAP-1 by caspase 8
-
-
?
cellular inhibitor of apoptosis 1 + H2O
?
i.e. cIAP-1, degradation. No activity with cIAP-2. In vitro substrate is recombinant human cIAP-1
-
-
?
HER-2 + H2O
?
37°C, HER-2 double mutant MT34, carrying the mutation D1125A/D837A
-
-
?
HER-2 + H2O
?
37°C, HER-2 double mutant MT35, carrying the mutation D1125A/D1087A, completely resistant to proteolysis
-
-
?
HER-2 + H2O
?
37°C, HER-2 double mutant MT36, carrying the mutation D1125A/D1115A
-
-
?
HER-2 + H2O
?
37°C, HER-2 mutant MT3, carrying the mutation D1125A, partially resistant to proteolysis
-
-
?
IETD-7-amido-4-trifluoromethylcoumarin + H2O
IETD + 7-amino-4-trifluoromethylcoumarin
-
-
-
?
IETD-7-amido-4-trifluoromethylcoumarin + H2O
IETD + 7-amino-4-trifluoromethylcoumarin
-
-
-
-
?
additional information
?
-
Mch2 and ICH1 are effectively cleaved only in the presence of native extract
-
-
?
additional information
?
-
the catalytic triad in caspase-8 comprises C260, H317 and the backbone carbonyl oxygen atom of R258, which points towards the Nepsilon atom of H317
-
-
?
additional information
?
-
-
the catalytic triad in caspase-8 comprises C260, H317 and the backbone carbonyl oxygen atom of R258, which points towards the Nepsilon atom of H317
-
-
?
additional information
?
-
caspase-8L acts as an inhibitor of caspase-8 by interfering with the binding of caspase-8 to FADD, i.e. Fas-associated protein with death domain, and is involved in the regulation of Fas-mediated apoptosis
-
-
?
additional information
?
-
-
caspase-8L acts as an inhibitor of caspase-8 by interfering with the binding of caspase-8 to FADD, i.e. Fas-associated protein with death domain, and is involved in the regulation of Fas-mediated apoptosis
-
-
?
additional information
?
-
caspase-8 is an initiator enzyme in the Fas-mediated pathway of which the downstream executioner caspase-3 is a physiological target
-
-
?
additional information
?
-
preferential recruitment of procaspase-8L by the BAP31 complex at the endoplasmic reticulum suggests an additional pathway for regulating initiator caspase-8 during apoptosis
-
-
?
additional information
?
-
MACH is the most upstream enzymatic component in the Fas/APO-1- and p55-R-induced cell death signaling cascade
-
-
?
additional information
?
-
CD95 and TNFR-1 death receptors initiate apoptosis by recruiting FLICE/MACH, which represents the apical triggering member of the protease death cascade and a target for the cell death inhibitor CrmA
-
-
?
additional information
?
-
the initiator caspase-8 activates other downstream caspases that are incapable of autocatalytic processing and activation
-
-
?
additional information
?
-
-
the initiator caspase-8 activates other downstream caspases that are incapable of autocatalytic processing and activation
-
-
?
p28Bap31 + H2O
additional information
-
-
the p20 cleavage product derives from the NH2 terminus of p28
?
p28Bap31 + H2O
additional information
-
-
-
the p20 cleavage product derives from the NH2 terminus of p28
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
cellular inhibitor of apoptosis 1 + H2O
?
i.e. cIAP-1, TRAIL-induced degradation of cIAP-1 requires caspase 8 activity, and it is, at least in part, due to direct cleavage of cIAP-1 by caspase 8
-
-
?
additional information
?
-
caspase-8L acts as an inhibitor of caspase-8 by interfering with the binding of caspase-8 to FADD, i.e. Fas-associated protein with death domain, and is involved in the regulation of Fas-mediated apoptosis
-
-
?
additional information
?
-
-
caspase-8L acts as an inhibitor of caspase-8 by interfering with the binding of caspase-8 to FADD, i.e. Fas-associated protein with death domain, and is involved in the regulation of Fas-mediated apoptosis
-
-
?
additional information
?
-
caspase-8 is an initiator enzyme in the Fas-mediated pathway of which the downstream executioner caspase-3 is a physiological target
-
-
?
additional information
?
-
preferential recruitment of procaspase-8L by the BAP31 complex at the endoplasmic reticulum suggests an additional pathway for regulating initiator caspase-8 during apoptosis
-
-
?
additional information
?
-
MACH is the most upstream enzymatic component in the Fas/APO-1- and p55-R-induced cell death signaling cascade
-
-
?
additional information
?
-
CD95 and TNFR-1 death receptors initiate apoptosis by recruiting FLICE/MACH, which represents the apical triggering member of the protease death cascade and a target for the cell death inhibitor CrmA
-
-
?
additional information
?
-
the initiator caspase-8 activates other downstream caspases that are incapable of autocatalytic processing and activation
-
-
?
additional information
?
-
-
the initiator caspase-8 activates other downstream caspases that are incapable of autocatalytic processing and activation
-
-
?
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
acetyl-IETD-aldehyde
IC50: 50 nM, covalently modifies the active site C360
benzyloxycarbonyl-DEVD-aldehyde
the inhibitor interacts favourably with the enzyme in subsite S4
cowpox serpin CrmA
CrmA, a pox virus-encoded serpin attenuates the ability of FLICE to activate downstrean caspases
-
Fas-associated death domain-like interleukin 1-converting enzyme-inhibitory proteins
FLIPs, natural inhibitor
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
6'-benzyloxy-4-bromo-2'-hydroxychalcone
compound displays potent cytotoxic properties against human leukaemia cells U-937, HL-60, K-562, NALM-6 and MOLT-3. Application results in significant activation of caspase-8 after 24 h of treatment
Fas-associated death domain protein-like interleukin-1-beta-converting enzyme-like inhibitory protein, long form
FLIP L, results in a heterodimeric enzyme
-
additional information
combination of interferon-alpha/TRAIL increases activity significantly
-
additional information
-
combination of interferon-alpha/TRAIL increases activity significantly
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acantholysis
The interaction of pemphigus autoimmunoglobulins with epidermal cells: activation of the fas apoptotic pathway and the use of caspase activity for pathogenicity tests of pemphigus patients.
Acquired Immunodeficiency Syndrome
Human immunodeficiency virus type 1 Vpr induces apoptosis in human neuronal cells.
Acquired Immunodeficiency Syndrome
Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)- and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3.
Adenocarcinoma
3-Oxoolean-12-en-27-oic acid isolated from Aceriphyllum rossii induces caspase-8-dependent apoptosis in human promyelocytic leukemia HL-60 cells.
Adenocarcinoma
Adenovirus-mediated gene transfer of caspase-8 sensitizes human adenocarcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand.
Adenocarcinoma
Apoptosis of colorectal adenocarcinoma induced by 5-FU and/or IFN-gamma through caspase 3 and caspase 8.
Adenocarcinoma
Association of Breast Cancer Susceptibility Variants with Risk of Pancreatic Cancer.
Adenocarcinoma
Caspase 8 polymorphisms contribute to the prognosis of advanced lung adenocarcinoma patients after platinum-based chemotherapy.
Adenocarcinoma
Caspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappaB through c-FLIP-L expression.
Adenocarcinoma
Clinicopathological significance of caspase-8 and caspase-10 expression in rectal cancer.
Adenocarcinoma
CpG island methylation of the MLH1, MGMT, DAPK, and CASP8 genes in cancerous and adjacent noncancerous stomach tissues.
Adenocarcinoma
Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure.
Adenocarcinoma
Features of the Copy Number Variation of Certain Genes in Tumor Cells in Patients with Serous Ovarian Adenocarcinoma.
Adenocarcinoma
GSK-3 inhibitors enhance TRAIL-mediated apoptosis in human gastric adenocarcinoma cells.
Adenocarcinoma
Immunohistochemical analysis of cell death pathways in gastrointestinal adenocarcinoma.
Adenocarcinoma
In vivo and in vitro activation of caspase-8 and -3 associated with Helicobacter pylori infection.
Adenocarcinoma
Irofulven (6-hydroxymethylacylfulvene, MGI 114) induces caspase 8 and 9-mediated apoptosis in human pancreatic adenocarcinoma cells.
Adenocarcinoma
Overexpression of cellular FLICE-inhibitory protein (FLIP) in gastric adenocarcinoma.
Adenocarcinoma
Reduced expression of caspase-8 and cleaved caspase-3 in pancreatic ductal adenocarcinoma cells.
Adenocarcinoma
Short hairpin RNA targeting c-FLIP sensitizes human cervical adenocarcinoma Hela cells to chemotherapy and radiotherapy.
Adenocarcinoma
Upregulation of c-FLIP-short in response to TRAIL promotes survival of NSCLC cells, which could be suppressed by inhibition of Ca(2+)/calmodulin signaling.
Adenocarcinoma
Variant TP53BP1 rs560191 G>C is associated with risk of gastric cardia adenocarcinoma in a Chinese Han population.
Adenocarcinoma
[Expression of cellular FLICE inhibitory protein (cFLIP) in endometrial adenocarcinoma]
Adenocarcinoma of Lung
Amplification activation loop between caspase-8 and -9 dominates artemisinin-induced apoptosis of ASTC-a-1 cells.
Adenocarcinoma of Lung
c-Src Increases the Sensitivity to TKIs in the EGFR-Mutant Lung Adenocarcinoma.
Adenocarcinoma of Lung
Caspase 8 polymorphisms contribute to the prognosis of advanced lung adenocarcinoma patients after platinum-based chemotherapy.
Adenocarcinoma of Lung
Dasatinib promotes paclitaxel-induced necroptosis in lung adenocarcinoma with phosphorylated caspase-8 by c-Src.
Adenocarcinoma of Lung
E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP(short).
Adenocarcinoma of Lung
lncCRLA enhanced chemoresistance in lung adenocarcinoma that underwent epithelial-mesenchymal transition.
Adenocarcinoma of Lung
Upregulation of c-FLIP-short in response to TRAIL promotes survival of NSCLC cells, which could be suppressed by inhibition of Ca(2+)/calmodulin signaling.
Adenoma
Clinicopathological significance of caspase-8 and caspase-10 expression in rectal cancer.
Adenoma
Independent induction of caspase-8 and cFLIP expression during colorectal carcinogenesis in sporadic and HNPCC adenomas and carcinomas.
Adenoma
TRAIL induces apoptosis in human colorectal adenoma cell lines and human colorectal adenomas.
Adenoma, Pleomorphic
Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
Adenomatous Polyposis Coli
Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis.
Aggressive Periodontitis
The role of caspase-8, caspase-9, and apoptosis inducing factor in periodontal disease.
Alopecia
Complex Changes in the Apoptotic and Cell Differentiation Programs during Initiation of the Hair Follicle Response to Chemotherapy.
Altitude Sickness
[Studies on apoptosis and caspase-8 and caspase-9 expressions of bone marrow cells in chronic mountain sickness].
Alzheimer Disease
Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis.
Alzheimer Disease
Beta-amyloid of Alzheimer's disease activates an apoptotic pathway via caspase-8.
Alzheimer Disease
Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants.
Alzheimer Disease
Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels.
Alzheimer Disease
Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein.
Alzheimer Disease
Machine Learning From Molecular Dynamics Trajectories to Predict Caspase-8 Inhibitors Against Alzheimer's Disease.
Alzheimer Disease
Study of Caspase 8 Inhibition for the Management of Alzheimer's Disease: A Molecular Docking and Dynamics Simulation.
Alzheimer Disease
Substrate-induced conformational changes occur in all cleaved forms of caspase-6.
Ameloblastoma
Expression of tumor necrosis factor alpha, TNF-related apoptosis-inducing ligand, and their associated molecules in ameloblastomas.
Ameloblastoma
TRAIL cleaves caspase-8, -9 and -3 of AM-1 cells: a possible pathway for TRAIL to induce apoptosis in ameloblastoma.
Amyotrophic Lateral Sclerosis
Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein.
Anencephaly
Apoptosis, Expression of PAX3 and P53, and Caspase Signal in Fetuses with Neural Tube Defects.
Aneurysm
CD95-Ligand contributes to abdominal aortic aneurysm progression by modulating inflammation.
Arteritis
The equine arteritis virus induces apoptosis via caspase-8 and mitochondria-dependent caspase-9 activation.
Arthritis
The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response.
Arthritis, Gouty
Simiao Decoction Alleviates Gouty Arthritis by Modulating Proinflammatory Cytokines and the Gut Ecosystem.
Arthritis, Rheumatoid
Fas/FasL, Bcl2 and Caspase-8 gene polymorphisms in Chinese patients with rheumatoid arthritis.
Arthritis, Rheumatoid
The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response.
Arthritis, Rheumatoid
[Expression of c-FLIP in peripheral blood mononuclear cells of patients with rheumatoid arthritis and its relation with extrinsic apoptotic pathway].
Asthma
Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation.
Asthma
Association of polymorphisms in CASP10 and CASP8 with FEV/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics.
Asthma
Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis.
Astrocytoma
Ubiquitin-proteasome pathway as a primary defender against TRAIL-mediated cell death.
Ataxia
Investigation of the Anticancer Mechanism of Isoorientin Isolated from Eremurus Spectabilis Leaves via Cell Cycle Pathways in HT-29 Human Colorectal Adenocarcinoma Cells.
Ataxia Telangiectasia
Beta-Ecdysone Protects Mouse Osteoblasts from Glucocorticoid-Induced Apoptosis In Vitro.
Ataxia Telangiectasia
Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer.
Ataxia Telangiectasia
Pharmacological targets and mechanisms of calycosin against meningitis.
Ataxia Telangiectasia
Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells.
Ataxia Telangiectasia
Tetrandrine Enhances H2O2-Induced Apoptotic Cell Death Through Caspase-dependent Pathway in Human Keratinocytes.
Atherosclerosis
5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Inhibits RIPK1/RIPK3-Dependent Necroptosis in THP-1-Derived Foam Cells.
Atherosclerosis
[Evaluation of endothelial function and estimation of the degree of apoptosis in patients with metabolic syndrome and non-alcoholic fatty liver disease].
Atrial Fibrillation
Mitochondrial apoptotic pathway activation in the atria of heart failure patients due to mitral and tricuspid regurgitation.
Autoimmune Diseases
Autoantibody against a protease domain of caspase-8 in patients with systemic sclerosis.
Autoimmune Diseases
Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner.
Autoimmune Diseases
[Analysis of Fas, FasL and Caspase-8 expression in thyroid gland in young patients with immune and non-immune thyroid diseases]
Autoimmune Lymphoproliferative Syndrome
A role for cFLIP in B cell proliferation and stress MAPK regulation.
Autoimmune Lymphoproliferative Syndrome
ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis.
Autoimmune Lymphoproliferative Syndrome
Bid truncation mediated by caspases-3 and -9 in vinorelbine-induced apoptosis.
Autoimmune Lymphoproliferative Syndrome
Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation.
Autoimmune Lymphoproliferative Syndrome
Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.
Autoimmune Lymphoproliferative Syndrome
Caspase-8 deficiency facilitates cellular transformation in vitro.
Autoimmune Lymphoproliferative Syndrome
Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease.
Autoimmune Lymphoproliferative Syndrome
Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3.
Autoimmune Lymphoproliferative Syndrome
Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder.
Autoimmune Lymphoproliferative Syndrome
Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma.
Autoimmune Lymphoproliferative Syndrome
Caspase-8 Deficiency Presenting as Late-Onset Multi-Organ Lymphocytic Infiltration with Granulomas in two Adult Siblings.
Autoimmune Lymphoproliferative Syndrome
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.
Autoimmune Lymphoproliferative Syndrome
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.
Autoimmune Lymphoproliferative Syndrome
Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner.
Autoimmune Lymphoproliferative Syndrome
Dynamic quantitative proteomics characterization of TNF-?-induced necroptosis.
Autoimmune Lymphoproliferative Syndrome
ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation.
Autoimmune Lymphoproliferative Syndrome
FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.
Autoimmune Lymphoproliferative Syndrome
Genetic defects of apoptosis and primary immunodeficiency.
Autoimmune Lymphoproliferative Syndrome
Immune disorders caused by defects in the caspase cascade.
Autoimmune Lymphoproliferative Syndrome
Integration of innate immune signaling by caspase-8 cleavage of N4BP1.
Autoimmune Lymphoproliferative Syndrome
Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency.
Autoimmune Lymphoproliferative Syndrome
Knockdown of IG20 gene expression renders thyroid cancer cells susceptible to apoptosis.
Autoimmune Lymphoproliferative Syndrome
Partial correction of abnormal cardiac development in caspase-8-deficient mice by cardiomyocyte expression of p 35.
Autoimmune Lymphoproliferative Syndrome
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.
Autoimmune Lymphoproliferative Syndrome
Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling.
Autoimmune Lymphoproliferative Syndrome
Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice.
Autoimmune Lymphoproliferative Syndrome
Requirement for caspase-8 in NF-kappaB activation by antigen receptor.
Autoimmune Lymphoproliferative Syndrome
Role of caspase-8 in hepatocyte response to infection and injury in mice.
Autoimmune Lymphoproliferative Syndrome
Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic.
Autoimmune Lymphoproliferative Syndrome
Targeting the tumor necrosis factor-related apoptosis-inducing ligand path in neuroblastoma.
Autoimmune Lymphoproliferative Syndrome
Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.
Autoimmune Lymphoproliferative Syndrome
The Autoimmune Lymphoproliferative Syndrome with Defective FAS or FAS-Ligand Functions.
Autoimmune Lymphoproliferative Syndrome
The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response.
Autoimmune Lymphoproliferative Syndrome
The technological transformation of patient-driven human immunology research.
Autoimmune Lymphoproliferative Syndrome
Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro.
Autoimmune Lymphoproliferative Syndrome
[Lymphoproliferative disorders and inborn errors of immunity].
Babesiosis
Porin Expression Profiles in Haemaphysalis longicornis Infected With Babesia microti.
Bacterial Infections
Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death.
Bacterial Infections
Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against Toxoplasma gondii.
Bacterial Infections
Caspases as the Key Effectors of Inflammatory Responses Against Bacterial Infection.
Bacterial Infections
Chronic activation of the kinase IKK? impairs T cell function and survival.
Bacterial Infections
Differential induction of apoptosis in human colonic carcinoma cells (Caco-2) by Atopobium, and commensal, probiotic and enteropathogenic bacteria: mediation by the mitochondrial pathway.
Barth Syndrome
Barth syndrome: Cellular compensation of mitochondrial dysfunction and apoptosis inhibition due to changes in cardiolipin remodeling linked to tafazzin gene mutation.
Barth Syndrome
Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid.
Blister
Surfactant protein D regulates caspase-8-mediated cascade of the intrinsic pathway of apoptosis while promoting bleb formation.
Brain Death
Direct Peritoneal Resuscitation Reduces Lung Injury and Caspase 8 Activity in Brain Death.
Brain Infarction
TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats.
Brain Injuries
Caspase inhibition by cardiotrophin-1 prevents neuronal death in vivo and in vitro.
Brain Injuries
Inhibiting caspase-8 after injury reduces hypoxic-ischemic brain injury in the newborn rat.
Brain Injuries
Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity.
Brain Injuries
Target inhibition of caspase-8 alleviates brain damage after subarachnoid hemorrhage.
Brain Injuries, Traumatic
Association between blood caspase-8 levels and mortality of patients with malignant middle cerebral artery infarction.
Brain Injuries, Traumatic
Low blood caspase-8 levels in survivor patients of traumatic brain injury.
Brain Injuries, Traumatic
Temporal and spatial profile of caspase 8 expression and proteolysis after experimental traumatic brain injury.
Brain Ischemia
PDZ1 inhibitor peptide protects neurons against ischemia via inhibiting GluK2-PSD-95-module-mediated Fas signaling pathway.
Brain Ischemia
The combination of isoflurane and caspase 8 inhibition results in sustained neuroprotection in rats subject to focal cerebral ischemia.
Brain Ischemia
Total saponins of Panax notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion.
Brain Ischemia
[Effect of active fraction of buyang huanwu decoction on caspase expression in rats after focal cerebral ischemic reperfusion]
Brain Ischemia
[Effects of Panax notoginseng saponins on mRNA expressions of interleukin-1 beta, its correlative factors and cysteinyl-aspartate specific protease after cerebral ischemia-reperfusion in rats]
Brain Neoplasms
Analysis of CASP8 D302H Gene Variants in Patients with Primary Brain Tumors.
Brain Neoplasms
Loss of caspase-8 mRNA expression is common in childhood primitive neuroectodermal brain tumour/medulloblastoma.
Brain Neoplasms
Over Expression of BCL2 and Low Expression of Caspase 8 Related to TRAIL Resistance in Brain Cancer Stem Cells.
Brain Neoplasms
Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults.
Brain Neoplasms
Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression.
Brain Neoplasms
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer.
Brain Neoplasms
Tetrazolium violet induces apoptosis via caspases-8, -9 activation and Fas/FasL up-regulation in rat C6 glioma cells.
Breast Neoplasms
2-MeOE2bisMATE induces caspase-dependent apoptosis in CAL51 breast cancer cells and overcomes resistance to TRAIL via cooperative activation of caspases.
Breast Neoplasms
4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells.
Breast Neoplasms
A systematic analysis of the association studies between CASP8 D302H polymorphisms and breast cancer risk.
Breast Neoplasms
Adeno-associated virus type 2 infection of nude mouse human breast cancer xenograft induces necrotic death and inhibits tumor growth.
Breast Neoplasms
AG36 Inhibits Human Breast Cancer Cells Proliferation by Promotion of Apoptosis In vitro and In vivo.
Breast Neoplasms
An empirical comparison of meta-analyses of published gene-disease associations versus consortium analyses.
Breast Neoplasms
Antioxidants in dietary oils: their potential role in breast cancer prevention.
Breast Neoplasms
Apoptosis induction in human breast cancer cell lines by synergic effect of raloxifene and resveratrol through increasing proapoptotic genes.
Breast Neoplasms
Association of a common variant of the CASP8 gene with reduced risk of breast cancer.
Breast Neoplasms
Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death.
Breast Neoplasms
Association of CASP8 D302H polymorphism with reduced risk of aggressive prostate carcinoma.
Breast Neoplasms
Association of CASP8 polymorphisms and cancer susceptibility: A meta-analysis.
Breast Neoplasms
Association of caspase 8 polymorphisms -652 6N InsDel and Asp302His with progression-free survival and tumor infiltrating lymphocytes in early breast cancer.
Breast Neoplasms
Association of caspase 8 promoter variants and haplotypes with the risk of breast cancer and its molecular profile in an Iranian population: A case-control study.
Breast Neoplasms
Association of the CASP10 V410I variant with reduced familial breast cancer risk and interaction with the CASP8 D302H variant.
Breast Neoplasms
Association of the Variants CASP8 D302H and CASP10 V410I with Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
Breast Neoplasms
Association of two CASP8 polymorphisms with breast cancer risk: a meta-analysis.
Breast Neoplasms
Balsamin induces apoptosis in breast cancer cells via DNA fragmentation and cell cycle arrest.
Breast Neoplasms
Bayesian variable selection using partially observed categorical prior information in fine-mapping association studies.
Breast Neoplasms
Bcl-xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells.
Breast Neoplasms
BCL2 and CASP8 regulation by NF-{kappa}B differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells.
Breast Neoplasms
beta-arrestin2 inhibits opioid-induced breast cancer cell death through Akt and caspase-8 pathways.
Breast Neoplasms
Bi-directional PCR allele-specific amplification (bi-PASA) for detection of caspase-8 -652 6N ins/del promoter polymorphism (rs3834129) in breast cancer.
Breast Neoplasms
Boosting GWAS using biological networks: A study on susceptibility to familial breast cancer.
Breast Neoplasms
CASP8 D302H polymorphism delays the age of onset of breast cancer in BRCA1 and BRCA2 carriers.
Breast Neoplasms
CASP8 polymorphisms, estrogen and progesterone receptor status, and breast cancer risk.
Breast Neoplasms
CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population.
Breast Neoplasms
Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation.
Breast Neoplasms
Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival.
Breast Neoplasms
Caspase-8 activation by TRAIL monotherapy predicts responses to IAPi and TRAIL combination treatment in breast cancer cell lines.
Breast Neoplasms
Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.
Breast Neoplasms
Chemical Composition of Aqueous Ethanol Extract of Luffa cylindrica Leaves and Its Effect on Representation of Caspase-8, Caspase-3, and the Proliferation Marker Ki67 in Intrinsic Molecular Subtypes of Breast Cancer in Vitro.
Breast Neoplasms
Chemotherapy with hybrid liposomes for human breast tumors along with apoptosis in vivo.
Breast Neoplasms
Cinnamomum cassia Suppresses Caspase-9 through Stimulation of AKT1 in MCF-7 Cells but Not in MDA-MB-231 Cells.
Breast Neoplasms
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk.
Breast Neoplasms
CUDC-907 enhances TRAIL-induced apoptosis through upregulation of DR5 in breast cancer cells.
Breast Neoplasms
Cytotoxic activity of octahydropyrazin[2,1-a:5,4-a']diisoquinoline derivatives in human breast cancer cells.
Breast Neoplasms
Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8.
Breast Neoplasms
Dichloromethane fraction of Moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (MCF7) by induction of apoptosis via upregulation of Bax, p53 and caspase 8 expressions.
Breast Neoplasms
Downregulation of Caspase 8 in a group of Iranian breast cancer patients - A pilot study.
Breast Neoplasms
Doxorubicin Changes Bax /Bcl-xL Ratio, Caspase-8 and 9 in Breast Cancer Cells.
Breast Neoplasms
Effect of miR-155 knockdown on the reversal of doxorubicin resistance in human lung cancer A549/dox cells.
Breast Neoplasms
Enhancement of tumor necrosis factor-alpha-induced growth inhibition by insulin-like growth factor-binding protein-5 (IGFBP-5), but not IGFBP-3 in human breast cancer cells.
Breast Neoplasms
Equol induces apoptosis through cytochrome c-mediated caspases cascade in human breast cancer MDA-MB-453 cells.
Breast Neoplasms
Evidences for association of the CASP8 -652 6N del promoter polymorphism with age at diagnosis in familial breast cancer cases.
Breast Neoplasms
Exemestane metabolites suppress growth of estrogen receptor-positive breast cancer cells by inducing apoptosis and autophagy: A comparative study with Exemestane.
Breast Neoplasms
Expression of 6 Common Antigenic Markers in Invasive Ductal Breast Carcinoma: Potential Clinical Implications.
Breast Neoplasms
Fas/FasL interaction of nucleus pulposus and cancer cells with the activation of caspases.
Breast Neoplasms
Fas/FasL-dependent and -independent activation of caspase-8 in doxorubicin-treated human breast cancer MCF-7 cells: ADAM10 down-regulation activates Fas/FasL signaling pathway.
Breast Neoplasms
Flavopiridol Induces Cellular FLICE-Inhibitory Protein Degradation by the Proteasome and Promotes TRAIL-Induced Early Signaling and Apoptosis in Breast Tumor Cells.
Breast Neoplasms
Fucoidan induces apoptosis through activation of caspase-8 on human breast cancer MCF-7 cells.
Breast Neoplasms
Functional screening of genes suppressing TRAIL-induced apoptosis: distinct inhibitory activities of Bcl-XL and Bcl-2.
Breast Neoplasms
Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer.
Breast Neoplasms
Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.
Breast Neoplasms
Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines.
Breast Neoplasms
Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis.
Breast Neoplasms
Important role of ?1-integrin in fucoidan-induced apoptosis via caspase-8 activation.
Breast Neoplasms
Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047.
Breast Neoplasms
Induction of interferon-? and interferon signaling by TRAIL and Smac mimetics via caspase-8 in breast cancer cells.
Breast Neoplasms
Inhibitory Effect of Lentivirus-Mediated Gag-Caspase-8 on the Growth of HER-2-Overexpressing Primary Human Breast Cancer Cells.
Breast Neoplasms
Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer.
Breast Neoplasms
Interferon-gamma treatment elevates caspase-8 expression and sensitizes human breast tumor cells to a death receptor-induced mitochondria-operated apoptotic program.
Breast Neoplasms
Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells.
Breast Neoplasms
Involvement of caspase-9 but not caspase-8 in the anti-apoptotic effects of estradiol and 4-OH-Estradiol in MCF-7 human breast cancer cells.
Breast Neoplasms
Itch/AIP4-independent proteasomal degradation of cFLIP induced by the histone deacetylase inhibitor SAHA sensitizes breast tumour cells to TRAIL.
Breast Neoplasms
Lentivirus-Based Virus-Like Particles Mediate Delivery of Caspase 8 into Breast Cancer Cells and Inhibit Tumor Growth.
Breast Neoplasms
Mechanism of 2',3'-dimethoxyflavanone-induced apoptosis in breast cancer stem cells: role of ubiquitination of caspase-8 and LC3.
Breast Neoplasms
Mutational analysis of apoptotic genes in familial aggregation of hematological malignancies.
Breast Neoplasms
Myricetin Apoptotic Effects on T47D Breast Cancer Cells is a P53-Independent Approach.
Breast Neoplasms
Myricetin Exerts its Apoptotic Effects on MCF-7 Breast Cancer Cells through Evoking the BRCA1-GADD45 Pathway.
Breast Neoplasms
Novel Bayes Factors That Capture Expert Uncertainty in Prior Density Specification in Genetic Association Studies.
Breast Neoplasms
Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study.
Breast Neoplasms
Novel synthetic triterpenoid methyl 25-hydroxy-3-oxoolean-12-en-28-oate induces apoptosis through JNK and p38 MAPK pathways in human breast adenocarcinoma MCF-7 cells.
Breast Neoplasms
PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1.
Breast Neoplasms
Polymorphisms in apoptosis- and proliferation-related genes, ionizing radiation exposure, and risk of breast cancer among U.S. Radiologic Technologists.
Breast Neoplasms
PQ1, a quinoline derivative, induces apoptosis in T47D breast cancer cells through activation of caspase-8 and caspase-9.
Breast Neoplasms
Predictive accuracy of the breast cancer genetic risk model based on eight common genetic variants: The BACkSIDE study.
Breast Neoplasms
Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer.
Breast Neoplasms
Re: Association of a common variant of the CASP8 gene with reduced risk of breast cancer.
Breast Neoplasms
Role of caspase-8 activation in mediating vitamin E-induced apoptosis in murine mammary cancer cells.
Breast Neoplasms
Role of specific apoptotic pathways in the restoration of paclitaxel-induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer cells.
Breast Neoplasms
Roles of the Bcl-2/Bax ratio, caspase-8 and 9 in resistance of breast cancer cells to paclitaxel.
Breast Neoplasms
shRNA mediated RHOXF1 silencing influences expression of BCL2 but not CASP8 in MCF-7 and MDA-MB-231 cell lines.
Breast Neoplasms
Silibinin-induced apoptosis in MCF7 and T47D human breast carcinoma cells involves caspase-8 activation and mitochondrial pathway.
Breast Neoplasms
Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.
Breast Neoplasms
Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin.
Breast Neoplasms
Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines.
Breast Neoplasms
Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models.
Breast Neoplasms
Synergy between RA and TLR3 promotes type I IFN-dependent apoptosis through upregulation of TRAIL pathway in breast cancer cells.
Breast Neoplasms
Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells.
Breast Neoplasms
Tamoxifen and TRAIL synergistically induce apoptosis in breast cancer cells.
Breast Neoplasms
The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study.
Breast Neoplasms
The CASP8 rs3834129 polymorphism and breast cancer risk in BRCA1 mutation carriers.
Breast Neoplasms
The cyclin-dependent kinase inhibitor SNS-032 induces apoptosis in breast cancer cells via depletion of Mcl-1 and X-linked inhibitor of apoptosis protein and displays antitumor activity in vivo.
Breast Neoplasms
The Fanconi anemia pathway sensitizes to DNA alkylating agents by inducing JNK-p53-dependent mitochondrial apoptosis in breast cancer cells.
Breast Neoplasms
The Impact of CASP8 rs10931936 and rs1045485 Polymorphisms as well as the Haplotypes on Breast Cancer Risk: A Case-Control Study.
Breast Neoplasms
The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.
Breast Neoplasms
The relationship of CASP 8 polymorphism and cancer susceptibility: a meta-analysis.
Breast Neoplasms
The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1.
Breast Neoplasms
Validating the meta-analytical results on MDM2, CASP8, XRCC3 polymorphisms and breast cancer risk: examination of Hardy-Weinberg Equilibrium.
Breast Neoplasms
[Analysis of apoptosis-related gene expression in different serum level of insulin-like growth factor-1 in mice breast cancer tissue]
Breast Neoplasms
[Clinical and Functional Importance of Selected CASP8 and CASP9 Polymorphisms in Breast Carcinoma].
Burkitt Lymphoma
Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent.
Burkitt Lymphoma
B cell receptor cross-linking triggers a caspase-8-dependent apoptotic pathway that is independent of the death effector domain of Fas-associated death domain protein.
Burkitt Lymphoma
Modulation of caspase-8 and FLICE-inhibitory protein expression as a potential mechanism of Epstein-Barr virus tumorigenesis in Burkitt's lymphoma.
Burkitt Lymphoma
p38-mediated regulation of an Fas-associated death domain protein-independent pathway leading to caspase-8 activation during TGFbeta-induced apoptosis in human Burkitt lymphoma B cells BL41.
Candidiasis
Capsular polysaccharide induction of apoptosis by intrinsic and extrinsic mechanisms.
Carcinogenesis
Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma.
Carcinogenesis
Arecoline N-Oxide Upregulates Caspase-8 Expression in Oral Hyperplastic Lesions of Mice.
Carcinogenesis
Association of the CASP10 V410I variant with reduced familial breast cancer risk and interaction with the CASP8 D302H variant.
Carcinogenesis
Cancer-associated missense mutations of caspase-8 activate nuclear factor-?B signaling.
Carcinogenesis
Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas.
Carcinogenesis
Caspase-8 polymorphisms and risk of gallbladder cancer in a northern Indian population.
Carcinogenesis
Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma.
Carcinogenesis
cFLIP isoforms block CD95- and trail death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signalling complex.
Carcinogenesis
Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis.
Carcinogenesis
COX-2/PGE2: molecular ambassadors of Kaposi's sarcoma-associated herpes virus oncoprotein-v-FLIP.
Carcinogenesis
Curcumin Nanoemulsions Stabilized with Modified Phosphatidylcholine on Skin Carcinogenesis Protocol.
Carcinogenesis
Effects of treatment of rats with indole-3-carbinol on apoptosis in the mammary gland and mammary adenocarcinomas.
Carcinogenesis
Estrogen-induced dimerization and activation of ER?-fused caspase-8: Artificial reversal of the estrogenic hormone effect in carcinogenesis.
Carcinogenesis
Ethanolic neem (Azadirachta indica) leaf extract induces apoptosis in the hamster buccal pouch carcinogenesis model by modulation of Bcl-2, Bim, caspase 8 and caspase 3.
Carcinogenesis
Expression levels of EPHB4, EFNB2 and caspase-8 are associated with clinicopathological features and progression of esophageal squamous cell cancer.
Carcinogenesis
Functional analysis of Kaposi's sarcoma-associated herpesvirus vFLIP expression reveals a new mode of IRES-mediated translation.
Carcinogenesis
Functional polymorphisms in apoptosis pathway genes and survival in patients with gastric cancer.
Carcinogenesis
Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.
Carcinogenesis
Independent induction of caspase-8 and cFLIP expression during colorectal carcinogenesis in sporadic and HNPCC adenomas and carcinomas.
Carcinogenesis
Knockdown of long noncoding RNA 00152 (LINC00152) inhibits human retinoblastoma progression.
Carcinogenesis
Menin-mediated Caspase 8 Expression in Suppressing Multiple Endocrine Neoplasia Type 1.
Carcinogenesis
MicroRNA-106b-5p boosts glioma tumorigensis by targeting multiple tumor suppressor genes.
Carcinogenesis
Modulation of caspase-8 and FLICE-inhibitory protein expression as a potential mechanism of Epstein-Barr virus tumorigenesis in Burkitt's lymphoma.
Carcinogenesis
Phosphatidylcholine induces growth inhibition of hepatic cancer by apoptosis via death ligands.
Carcinogenesis
Promoter methylation pattern of caspase-8, P16INK4A, MGMT, TIMP-3, and E-cadherin in medulloblastoma.
Carcinogenesis
Reduction of fibrosis and immune suppressive cells in ErbB2-dependent tumorigenesis by an LXR agonist.
Carcinogenesis
Salidroside induces cell apoptosis and inhibits the invasiveness of HT29 colorectal cells by regulating protein kinase R, NF-?B and STAT3.
Carcinogenesis
Water extract of brewers' rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/?-catenin downstream signaling pathway in brewers' rice-treated rats with azoxymethane-induced colon carcinogenesis.
Carcinogenesis
Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells.
Carcinoid Tumor
Identification of deregulation of apoptosis and cell cycle in neuroendocrine tumors of the lung via NanoString nCounter expression analysis.
Carcinoma
2-Methoxyestradiol-induced caspase-3 activation and apoptosis occurs through G(2)/M arrest dependent and independent pathways in gastric carcinoma cells.
Carcinoma
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter associated with risk and progression of bladder cancer.
Carcinoma
Adenovirus-mediated transfection of caspase-8 augments anoikis and inhibits peritoneal dissemination of human gastric carcinoma cells.
Carcinoma
Akt inhibitor enhances apoptotic effect of carboplatin on human epithelial ovarian carcinoma cell lines.
Carcinoma
Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact.
Carcinoma
Analysis of the gene-expression profile regarding the progression of human gastric carcinoma.
Carcinoma
Anti-apoptotic proteins Bcl-2/Bcl-XL inhibit Clostridium difficile toxin A-induced cell death in human epithelial cells.
Carcinoma
Association of CASP8 D302H polymorphism with reduced risk of aggressive prostate carcinoma.
Carcinoma
Association of caspase-8 mutation with chemoresistance to cisplatin in HOC313 head and neck squamous cell carcinoma cells.
Carcinoma
Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and Brachytherapy.
Carcinoma
Bortezomib Sensitizes Human Renal Cell Carcinomas to TRAIL Apoptosis through Increased Activation of Caspase-8 in the Death-Inducing Signaling Complex.
Carcinoma
c-Abl Is an Upstream Regulator of Acid Sphingomyelinase in Apoptosis Induced by Inhibition of Integrins ?v?3 and ?v?5.
Carcinoma
CASP8 (rs3834129) and CASP3 (rs4647601) polymorphisms in oropharynx cancer risk, tumor cell differentiation, and prognosis in a cohort of the Brazilian population.
Carcinoma
CASP8 -652 6N del and CASP8 IVS12-19G>A gene polymorphisms and susceptibility/prognosis of ESCC: A case control study in northern Indian population.
Carcinoma
Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP.
Carcinoma
Caspase-8 expression and its Src-dependent phosphorylation on Tyr380 promote cancer cell neoplastic transformation and resistance to anoikis.
Carcinoma
Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic-induced necroptosis.
Carcinoma
Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes.
Carcinoma
Co-expression of caspase-3 or caspase-8 with galanin in the human stomach section affected by carcinoma.
Carcinoma
Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis.
Carcinoma
Combined application of camptothecin and the guanylate cyclase activator YC-1: Impact on cell death and apoptosis-related proteins in ovarian carcinoma cell lines.
Carcinoma
Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL.
Carcinoma
Cytotoxicity of ICD-85 NPs on Human Cervical Carcinoma HeLa Cells through Caspase-8 Mediated Pathway.
Carcinoma
Delayed caspase-8 activation and enhanced integrin ?1-activated FAK underpins anoikis in oesophageal carcinoma cells harbouring mt p53-R175H.
Carcinoma
Detecting promoter methylation pattern of apoptotic genes Apaf1 and Caspase8 in gastric carcinoma patients undergoing chemotherapy.
Carcinoma
Differential expression of intracellular apoptotic signaling molecules in tumor and tumor-infiltrating lymphocytes during development of invasion and/or metastasis of gastric carcinoma.
Carcinoma
Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines.
Carcinoma
Doxorubicin and etoposide sensitize small cell lung carcinoma cells expressing caspase-8 to TRAIL.
Carcinoma
Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis.
Carcinoma
Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates TNF-alpha-mediated activation of NF-kappaB and caspase-8.
Carcinoma
Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells.
Carcinoma
Ethanolic neem (Azadirachta indica) leaf extract induces apoptosis in the hamster buccal pouch carcinogenesis model by modulation of Bcl-2, Bim, caspase 8 and caspase 3.
Carcinoma
Evaluation of caspase-3 and caspase-8 deregulation in tongue squamous cell carcinoma, based on immunohistochemistry and computerised image analysis.
Carcinoma
Expression and prognostic significance of APAF-1, caspase-8 and caspase-9 in stage II/III colon carcinoma: Caspase-8 and caspase-9 is associated with poor prognosis.
Carcinoma
Expression levels of EPHB4, EFNB2 and caspase-8 are associated with clinicopathological features and progression of esophageal squamous cell cancer.
Carcinoma
Fas-induced apoptosis of renal cell carcinoma is mediated by apoptosis signal-regulating kinase 1 via mitochondrial damage-dependent caspase-8 activation.
Carcinoma
Fas-mediated apoptosis in human prostatic carcinoma cell lines occurs via activation of caspase-8 and caspase-7.
Carcinoma
Functional polymorphisms in cell death pathway genes and risk of renal cell carcinoma.
Carcinoma
Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas.
Carcinoma
Harmol induces apoptosis by caspase-8 activation independently on Fas/Fas ligand interaction in human lung carcinoma H596 cells.
Carcinoma
Heterogeneous role of caspase-8 in fenretinide-induced apoptosis in epithelial ovarian carcinoma cell lines.
Carcinoma
High level of cFLIP correlates with resistance to death receptor-induced apoptosis in bladder carcinoma cells.
Carcinoma
Identification of a secondary promoter of CASP8 and its related transcription factor PUR?.
Carcinoma
Identification of deregulation of apoptosis and cell cycle in neuroendocrine tumors of the lung via NanoString nCounter expression analysis.
Carcinoma
Identification of the apoptosis activation cascade induced in mammary carcinomas by energy restriction.
Carcinoma
In silico analysis reveals a shared immune signature in CASP8-mutated carcinomas with varying correlations to prognosis.
Carcinoma
Independent induction of caspase-8 and cFLIP expression during colorectal carcinogenesis in sporadic and HNPCC adenomas and carcinomas.
Carcinoma
Inducing regulated necrosis and shifting macrophage polarization with anti-EMMPRIN antibody (161-pAb) and complement factors.
Carcinoma
Induction of apoptosis by chemotherapeutic drugs: the role of FADD in activation of caspase-8 and synergy with death receptor ligands in ovarian carcinoma cells.
Carcinoma
Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells.
Carcinoma
Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer.
Carcinoma
Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation.
Carcinoma
Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death.
Carcinoma
Interferon-gamma modulates TRAIL-mediated apoptosis in human colon carcinoma cells.
Carcinoma
Is there any potential link among caspase-8, p-p38 MAPK and bcl-2 in clear cell renal cell carcinomas? A comparative immunohistochemical analysis with clinical connotations.
Carcinoma
Lack of death receptor 4 (DR4) expression through gene promoter methylation in gastric carcinoma.
Carcinoma
Loss of caspase-8 activation pathway is a possible mechanism for CDDP resistance in human laryngeal squamous cell carcinoma, HEp-2 cells.
Carcinoma
Metformin-induced apoptosis facilitates degradation of the cellular caspase 8 (FLICE)-like inhibitory protein through a caspase-dependent pathway in human renal cell carcinoma A498 cells.
Carcinoma
Methods for simultaneous measurement of apoptosis and cell surface phenotype of epithelial cells in effusions by flow cytometry.
Carcinoma
Mutation Analysis of the Dimer Forming Domain of the Caspase 8 Gene in Oral Submucous Fibrosis and Squamous Cell Carcinomas.
Carcinoma
PECAM-1 shedding during apoptosis generates a membrane-anchored truncated molecule with unique signaling characteristics.
Carcinoma
Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy.
Carcinoma
Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells.
Carcinoma
Regularly methylated novel pro-apoptotic genes associated with recurrence in transitional cell carcinoma of the bladder.
Carcinoma
Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes.
Carcinoma
Retinoic acid induces caspase-8 transcription via phospho-CREB and increases apoptotic responses to death stimuli in neuroblastoma cells.
Carcinoma
Role of caspase 8 as a determinant in chemosensitivity of p53-mutated head and neck squamous cell carcinoma cell lines.
Carcinoma
Selective in situ protein expression profiles correlate with distinct phenotypes of basal cell carcinoma and squamous cell carcinoma of the skin.
Carcinoma
Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines.
Carcinoma
Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation.
Carcinoma
Tanshinone IIA Facilitates TRAIL Sensitization by Up-regulating DR5 through the ROS-JNK-CHOP Signaling Axis in Human Ovarian Carcinoma Cell Lines.
Carcinoma
The CASP8 -652 6N insertion/deletion promoter polymorphism is associated with renal cell carcinoma risk and metastasis.
Carcinoma
The combination of TPL2 knockdown and TNF? causes synthetic lethality via caspase-8 activation in human carcinoma cell lines.
Carcinoma
The determination of stage in nonmuscle urothelial carcinoma: Staining pattern of caspase-8.
Carcinoma
The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck.
Carcinoma
Up-regulation of FLIP in cisplatin-selected HeLa cells causes cross-resistance to CD95/Fas death signalling.
Carcinoma
Upregulation of c-FLIP-short in response to TRAIL promotes survival of NSCLC cells, which could be suppressed by inhibition of Ca(2+)/calmodulin signaling.
Carcinoma
[Expression of Fas, Fas ligand, Fas-associated death domain protein, caspase 8 and mutant P53 protein in esophageal squamous cell carcinoma]
Carcinoma
[Expressions of receptor-interacting protein and caspase-8 in oral squamous cell carcinoma and oral precancerous lesions.]
Carcinoma
[The expression and activity of caspase-8 in the process of vitamin E succinate-induced apoptosis in human gastric carcinoma SGC-7901 cells]
Carcinoma, Embryonal
ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation.
Carcinoma, Hepatocellular
Activation of caspase-8 during N-(4-hydroxyphenyl)retinamide-induced apoptosis in Fas-defective hepatoma cells.
Carcinoma, Hepatocellular
Activation of caspase-8 in transforming growth factor-beta-induced apoptosis of human hepatoma cells.
Carcinoma, Hepatocellular
Adenoviral-mediated transfer of p53 gene enhances TRAIL-induced apoptosis in human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Adenovirus-mediated transfection of caspase-8 sensitizes hepatocellular carcinoma to TRAIL- and chemotherapeutic agent-induced cell death.
Carcinoma, Hepatocellular
Apoptosis-inducing activity of the antimicrobial peptide cecropin of Musca domestica in human hepatocellular carcinoma cell line BEL-7402 and the possible mechanism.
Carcinoma, Hepatocellular
ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation.
Carcinoma, Hepatocellular
ASB3 knockdown promotes mitochondrial apoptosis via activating the interdependent cleavage of Beclin1 and caspase-8 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Caspase-8 acts as a key upstream executor of mitochondria during justicidin A-induced apoptosis in human hepatoma cells.
Carcinoma, Hepatocellular
Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas.
Carcinoma, Hepatocellular
Caspase-8 in apoptosis of hepatoma cell induced by 5-fluorouracil.
Carcinoma, Hepatocellular
Combination of 5-FU and IFNalpha enhances IFN signaling pathway and caspase-8 activity, resulting in marked apoptosis in hepatoma cell lines.
Carcinoma, Hepatocellular
Connexin32 activates necroptosis through Src-mediated inhibition of caspase 8 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Cytosolic and nuclear caspase-8 have opposite impact on survival after liver resection for hepatocellular carcinoma.
Carcinoma, Hepatocellular
DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8.
Carcinoma, Hepatocellular
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.
Carcinoma, Hepatocellular
Epigenetic methylation and expression of caspase 8 and survivin in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Galangin induces apoptosis in hepatocellular carcinoma cells through the caspase 8/t-Bid mitochondrial pathway.
Carcinoma, Hepatocellular
Genetic variants in cell death pathway genes and HBV-related hepatocellular carcinoma among a Chinese Han population.
Carcinoma, Hepatocellular
Geranylgeraniol, an intermediate product in mevalonate pathway, induces apoptotic cell death in human hepatoma cells: death receptor-independent activation of caspase-8 with down-regulation of Bcl-xL expression.
Carcinoma, Hepatocellular
Glucocorticoid protects hepatoma cells against metabolic stress-induced cell death.
Carcinoma, Hepatocellular
Glycogen synthase kinase-3 inhibitors augment TRAIL-induced apoptotic death in human hepatoma cells.
Carcinoma, Hepatocellular
HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 and repressing p27Kip1/CDK2 signaling.
Carcinoma, Hepatocellular
Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi.
Carcinoma, Hepatocellular
Immunomodulatory, Apoptosis Induction and Antitumor Activities of Aqueous and Methanolic Extract of Calvatia Craniiformis in Mice Transfected with Murine Hepatocellular Carcinoma Cells.
Carcinoma, Hepatocellular
Inhibitory effects of short hairpin RNA against caspase-8 on apoptosis of murine hepatoma Hepa1-6 cells.
Carcinoma, Hepatocellular
Interferon-alpha enhances TRAIL-mediated apoptosis by up-regulating caspase-8 transcription in human hepatoma cells.
Carcinoma, Hepatocellular
Isolation of 4,4'-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma.
Carcinoma, Hepatocellular
Mitochondria-mediated tumstatin peptide-induced HepG2 cell apoptosis.
Carcinoma, Hepatocellular
Molecular mechanism of Mitomycin C-dependent caspase-8 regulation: implications for apoptosis and synergism with interferon-alpha signalling.
Carcinoma, Hepatocellular
Molecular mechanisms of apoptosis in hepatocellular carcinoma cells induced by ethanol extracts of
Carcinoma, Hepatocellular
Mutations to bid cleavage sites protect hepatocytes from apoptosis after ischemia/reperfusion injury.
Carcinoma, Hepatocellular
NET-1 promotes invasion, adhesion and growth of hepatocellular carcinoma by regulating the expression of BAX, caspase 3, caspase 8 and BCL2.
Carcinoma, Hepatocellular
NLRP3 inflammasome expression is driven by NF-?B in cultured hepatocytes.
Carcinoma, Hepatocellular
P60-c-src suppresses apoptosis through inhibition of caspase 8 activation in hepatoma cells, but not in primary hepatocytes.
Carcinoma, Hepatocellular
RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation.
Carcinoma, Hepatocellular
Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation.
Carcinoma, Hepatocellular
SAHA induces apoptosis in hepatoma cells and synergistically interacts with the proteasome inhibitor Bortezomib.
Carcinoma, Hepatocellular
Sann-Joong-Kuey-Jian-Tang inhibits hepatocellular carcinoma Hep-G2 cell proliferation by increasing TNF-?, Caspase-8, Caspase- 3 and Bax but by decreasing TCTP and Mcl-1 expression in vitro.
Carcinoma, Hepatocellular
Silencing of caspase-8 in murine hepatocellular carcinomas is mediated via methylation of an essential promoter element.
Carcinoma, Hepatocellular
Supernatant of bacterial fermented soybean induces apoptosis of human hepatocellular carcinoma Hep 3B cells via activation of caspase 8 and mitochondria.
Carcinoma, Hepatocellular
The human caspase-8 promoter sustains basal activity through SP1 and ETS-like transcription factors and can be up-regulated by a p53-dependent mechanism.
Carcinoma, Hepatocellular
The role of death effector domain (DED)-containing proteins in acute oxidative cell injury in hepatocytes.
Carcinoma, Hepatocellular
The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer.
Carcinoma, Hepatocellular
Translocase of outer mitochondrial membrane 70 expression is induced by hepatitis C virus and is related to the apoptotic response.
Carcinoma, Hepatocellular
Triggering apoptosis by oroxylin A through caspase-8 activation and p62/SQSTM1 proteolysis.
Carcinoma, Hepatocellular
[Role of caspase-8 and caspase-3 in hepatoma cells apoptosis induced by 5-fluorouracil]
Carcinoma, Medullary
Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive to tumor necrosis factor-related apoptosis-inducing ligand.
Carcinoma, Mucoepidermoid
Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
Carcinoma, Non-Small-Cell Lung
A combination of functional polymorphisms in the CASP8, MMP1, IL10 and SEPS1 genes affects risk of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Apoptosis by gemcitabine in non-small cell lung cancer cell line KNS62 is induced downstream of caspase 8 and is profoundly blocked by Bcl-xL over-expression.
Carcinoma, Non-Small-Cell Lung
Apoptosis-Inducing Activity of Marine Sponge Haliclona sp. Extracts Collected from Kosrae in Nonsmall Cell Lung Cancer A549 Cells.
Carcinoma, Non-Small-Cell Lung
Artemisinin induces A549 cell apoptosis dominantly via a reactive oxygen species-mediated amplification activation loop among caspase-9, -8 and -3.
Carcinoma, Non-Small-Cell Lung
Association Between CASP8 and CASP10 Polymorphisms and Toxicity Outcomes with Platinum-Based Chemotherapy in Chinese Patients with Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Caspase-8 knockdown suppresses apoptosis, while induces autophagy and chemo-sensitivity in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Enhancement of Apo2L/TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis in non-small cell lung cancer cell lines by chemotherapeutic agents without correlation to the expression level of cellular protease caspase-8 inhibitory protein.
Carcinoma, Non-Small-Cell Lung
Gefitinib induces cytoplasmic translocation of the CDK inhibitor p27 and its binding to a cleaved intermediate of caspase 8 in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
miR-34c may protect lung cancer cells from paclitaxel-induced apoptosis.
Carcinoma, Non-Small-Cell Lung
Pharmacological inhibition of caspase-8 limits lung tumour outgrowth.
Carcinoma, Non-Small-Cell Lung
Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese.
Carcinoma, Non-Small-Cell Lung
Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation.
Carcinoma, Non-Small-Cell Lung
The ?-Carboline Alkaloid Harmol Induces Cell Death via Autophagy but Not Apoptosis in Human Non-small Cell Lung Cancer A549 Cells.
Carcinoma, Non-Small-Cell Lung
The impact of Caspase-8 on non-small cell lung cancer brain metastasis in II/III stage patient.
Carcinoma, Non-Small-Cell Lung
Upregulation of c-FLIP-short in response to TRAIL promotes survival of NSCLC cells, which could be suppressed by inhibition of Ca(2+)/calmodulin signaling.
Carcinoma, Non-Small-Cell Lung
[Expression of caspase-8 in non-small cell lung cancer and its role in invasion and metastasis of lung cancer A549 cells].
Carcinoma, Non-Small-Cell Lung
[Expression of phosphorylated caspase-8 in non-small cell lung cancer and the clinical implications].
Carcinoma, Ovarian Epithelial
Heterogeneous role of caspase-8 in fenretinide-induced apoptosis in epithelial ovarian carcinoma cell lines.
Carcinoma, Ovarian Epithelial
Long isoform cellular FLICE inhibitory protein expression defines two ovarian cancer patient subsets and is a prognostic factor of adverse outcome.
Carcinoma, Ovarian Epithelial
Perturbation of the tumor necrosis factor--related apoptosis-inducing ligand cascade in ovarian cancer: overexpression of FLIPL and deregulation of the functional receptors DR4 and DR5.
Carcinoma, Ovarian Epithelial
Polymorphisms in the CASP8 gene and the risk of epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Single CpG island methylation is not sufficient to maintain the silenced expression of CASPASE-8 apoptosis-related gene among women with epithelial ovarian cancer.
Carcinoma, Papillary
Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive to tumor necrosis factor-related apoptosis-inducing ligand.
Carcinoma, Renal Cell
Bortezomib Sensitizes Human Renal Cell Carcinomas to TRAIL Apoptosis through Increased Activation of Caspase-8 in the Death-Inducing Signaling Complex.
Carcinoma, Renal Cell
Caspase-8 and its inhibitors in RCCs in vivo: the prominent role of ARC.
Carcinoma, Renal Cell
Fas-induced apoptosis of renal cell carcinoma is mediated by apoptosis signal-regulating kinase 1 via mitochondrial damage-dependent caspase-8 activation.
Carcinoma, Renal Cell
Functional polymorphisms in cell death pathway genes and risk of renal cell carcinoma.
Carcinoma, Renal Cell
Inducing regulated necrosis and shifting macrophage polarization with anti-EMMPRIN antibody (161-pAb) and complement factors.
Carcinoma, Renal Cell
Metformin-induced apoptosis facilitates degradation of the cellular caspase 8 (FLICE)-like inhibitory protein through a caspase-dependent pathway in human renal cell carcinoma A498 cells.
Carcinoma, Renal Cell
The CASP8 -652 6N insertion/deletion promoter polymorphism is associated with renal cell carcinoma risk and metastasis.
Carcinoma, Squamous Cell
Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact.
Carcinoma, Squamous Cell
Association of caspase-8 mutation with chemoresistance to cisplatin in HOC313 head and neck squamous cell carcinoma cells.
Carcinoma, Squamous Cell
Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and Brachytherapy.
Carcinoma, Squamous Cell
Berberine induced apoptosis via promoting the expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G in SCC-4 human tongue squamous carcinoma cancer cells.
Carcinoma, Squamous Cell
CASP8 (rs3834129) and CASP3 (rs4647601) polymorphisms in oropharynx cancer risk, tumor cell differentiation, and prognosis in a cohort of the Brazilian population.
Carcinoma, Squamous Cell
Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic-induced necroptosis.
Carcinoma, Squamous Cell
Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis.
Carcinoma, Squamous Cell
Ethanolic neem (Azadirachta indica) leaf extract induces apoptosis in the hamster buccal pouch carcinogenesis model by modulation of Bcl-2, Bim, caspase 8 and caspase 3.
Carcinoma, Squamous Cell
Evaluation of caspase-3 and caspase-8 deregulation in tongue squamous cell carcinoma, based on immunohistochemistry and computerised image analysis.
Carcinoma, Squamous Cell
In silico analysis reveals a shared immune signature in CASP8-mutated carcinomas with varying correlations to prognosis.
Carcinoma, Squamous Cell
Loss of caspase-8 activation pathway is a possible mechanism for CDDP resistance in human laryngeal squamous cell carcinoma, HEp-2 cells.
Carcinoma, Squamous Cell
Mutation Analysis of the Dimer Forming Domain of the Caspase 8 Gene in Oral Submucous Fibrosis and Squamous Cell Carcinomas.
Carcinoma, Squamous Cell
Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy.
Carcinoma, Squamous Cell
Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes.
Carcinoma, Squamous Cell
Resistance to apoptosis of HPV 16-infected laryngeal cancer cells is associated with decreased Bak and increased Bcl-2 expression.
Carcinoma, Squamous Cell
Role of caspase 8 as a determinant in chemosensitivity of p53-mutated head and neck squamous cell carcinoma cell lines.
Carcinoma, Squamous Cell
The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck.
Carcinoma, Squamous Cell
Translational Genomics and Recent Advances in Oral Squamous Cell Carcinoma.
Carcinoma, Transitional Cell
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter associated with risk and progression of bladder cancer.
Carcinoma, Transitional Cell
Regularly methylated novel pro-apoptotic genes associated with recurrence in transitional cell carcinoma of the bladder.
Cardiomyopathies
Nutritional leucine supplementation attenuates cardiac failure in tumour-bearing cachectic animals.
Cardiotoxicity
MicroRNA-98 ameliorates doxorubicin-induced cardiotoxicity via regulating caspase-8 dependent Fas/RIP3 pathway.
caspase-6 deficiency
Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7.
caspase-8 deficiency
ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis.
caspase-8 deficiency
Bid truncation mediated by caspases-3 and -9 in vinorelbine-induced apoptosis.
caspase-8 deficiency
Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation.
caspase-8 deficiency
Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.
caspase-8 deficiency
Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease.
caspase-8 deficiency
Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3.
caspase-8 deficiency
Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder.
caspase-8 deficiency
Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma.
caspase-8 deficiency
Caspase-8 Deficiency Presenting as Late-Onset Multi-Organ Lymphocytic Infiltration with Granulomas in two Adult Siblings.
caspase-8 deficiency
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.
caspase-8 deficiency
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.
caspase-8 deficiency
Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner.
caspase-8 deficiency
Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.
caspase-8 deficiency
Dynamic quantitative proteomics characterization of TNF-?-induced necroptosis.
caspase-8 deficiency
ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation.
caspase-8 deficiency
FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.
caspase-8 deficiency
Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency.
caspase-8 deficiency
Knockdown of IG20 gene expression renders thyroid cancer cells susceptible to apoptosis.
caspase-8 deficiency
Partial correction of abnormal cardiac development in caspase-8-deficient mice by cardiomyocyte expression of p 35.
caspase-8 deficiency
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.
caspase-8 deficiency
Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling.
caspase-8 deficiency
Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice.
caspase-8 deficiency
Requirement for caspase-8 in NF-kappaB activation by antigen receptor.
caspase-8 deficiency
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.
caspase-8 deficiency
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.
caspase-8 deficiency
Role of caspase-8 in hepatocyte response to infection and injury in mice.
caspase-8 deficiency
Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic.
caspase-8 deficiency
Targeting the tumor necrosis factor-related apoptosis-inducing ligand path in neuroblastoma.
caspase-8 deficiency
Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.
caspase-8 deficiency
The Autoimmune Lymphoproliferative Syndrome with Defective FAS or FAS-Ligand Functions.
caspase-8 deficiency
The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response.
caspase-8 deficiency
The technological transformation of patient-driven human immunology research.
caspase-8 deficiency
Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro.
caspase-9 deficiency
Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling.
Cell Transformation, Neoplastic
Caspase-8 expression and its Src-dependent phosphorylation on Tyr380 promote cancer cell neoplastic transformation and resistance to anoikis.
Cell Transformation, Neoplastic
Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: An Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axis.
Chagas Disease
Caspase-8 activity is part of the BeWo trophoblast cell defense mechanisms against Trypanosoma cruzi infection.
Chagas Disease
Caspase-8 activity prevents type 2 cytokine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection.
Cholangitis
Inactivation of caspase 8 in liver parenchymal cells confers protection against murine obstructive cholestasis.
Cholera
Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction.
Cholestasis
Inactivation of caspase 8 in liver parenchymal cells confers protection against murine obstructive cholestasis.
Cholestasis, Intrahepatic
Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant rat models.
Cholesteatoma
Caspase-3, caspase-8, and nuclear factor-kappaB expression in human cholesteatoma.
Chorioamnionitis
Apoptosis and proliferation in lungs of human fetuses exposed to chorioamnionitis.
Choriocarcinoma
Caspase activity is downregulated in choriocarcinoma: a cDNA array differential expression study.
Chronic Periodontitis
Loss of periodontal ligament fibroblasts by RIPK3-MLKL-mediated necroptosis in the progress of chronic periodontitis.
Coinfection
Activation of extrinsic apoptosis pathway in HCV monoinfected and HIV-HCV coinfected patients, irrespective of liver disease severity.
Colitis
Extracellular Vesicles Derived from Bone Marrow Mesenchymal Stem Cells Protect against Experimental Colitis via Attenuating Colon Inflammation, Oxidative Stress and Apoptosis.
Colitis
FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.
Colitis
Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in mice.
Colitis
Neutrophil apoptosis is delayed in an equine model of colitis: Implications for the development of SIRS.
Colonic Neoplasms
17-Hydroxy Wortmannin Restores TRAIL's Response by Ameliorating Increased Beclin 1 Level and Autophagy Function in TRAIL-Resistant Colon Cancer Cells.
Colonic Neoplasms
5-Fluorouracil efficiently enhanced apoptosis induced by adenovirus-mediated transfer of caspase-8 in DLD-1 colon cancer cells.
Colonic Neoplasms
?-Catenin-dependent lysosomal targeting of internalized tumor necrosis factor-? suppresses caspase-8 activation in apoptosis-resistant colon cancer cells.
Colonic Neoplasms
A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-8.
Colonic Neoplasms
A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis.
Colonic Neoplasms
Accelerated degradation of caspase-8 protein correlates with TRAIL resistance in a DLD1 human colon cancer cell line.
Colonic Neoplasms
Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells.
Colonic Neoplasms
Anti-apoptotic proteins Bcl-2/Bcl-XL inhibit Clostridium difficile toxin A-induced cell death in human epithelial cells.
Colonic Neoplasms
Bax?2 Promotes Apoptosis through Caspase-8 Activation in Microsatellite-Unstable Colon Cancer.
Colonic Neoplasms
Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells.
Colonic Neoplasms
Calotroposid A: a Glycosides Terpenoids from Calotropis gigantea Induces Apoptosis of Colon Cancer WiDr Cells
through Cell Cycle Arrest G2/M and Caspase 8 Expression
Colonic Neoplasms
Cardamonin Sensitizes Tumor Cells to TRAIL Through ROS- and CHOP-Mediated Upregulation of Death Receptors and Downregulation of Survival Proteins.
Colonic Neoplasms
Caspase-8 activation independent of CD95/CD95-L interaction during paclitaxel-induced apoptosis in human colon cancer cells (HT29-D4).
Colonic Neoplasms
Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin.
Colonic Neoplasms
Caspase-8 expression and its Src-dependent phosphorylation on Tyr380 promote cancer cell neoplastic transformation and resistance to anoikis.
Colonic Neoplasms
Caspase-8 gene transduction augments radiation-induced apoptosis in DLD-1 cells.
Colonic Neoplasms
Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway.
Colonic Neoplasms
Dicaffeoylquinic acids in Yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF-?B nucleus translocation in macrophages and induce apoptosis by activating caspases-8 and -3 in human colon cancer cells.
Colonic Neoplasms
Discovery of Novel 2-Amino-5-(Substituted)-1,3,4-Thiadiazole Derivatives: New Utilities for Colon Cancer Treatment.
Colonic Neoplasms
Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines.
Colonic Neoplasms
Enhancement of chemosensitivity in 5-fluorouracil-resistant colon cancer cells with carcinoembryonic antigen-specific RNA aptamer.
Colonic Neoplasms
Enterolactone induces apoptosis and inhibits growth of Colo 201 human colon cancer cells both in vitro and in vivo.
Colonic Neoplasms
Epigallocatechin-3-Gallate Induces Apoptosis as a TRAIL Sensitizer via Activation of Caspase 8 and Death Receptor 5 in Human Colon Cancer Cells.
Colonic Neoplasms
Exploring SNP-SNP interactions and colon cancer risk using polymorphism interaction analysis.
Colonic Neoplasms
Expression of cellular FLICE-inhibitory protein and its association with p53 mutation in colon cancer.
Colonic Neoplasms
Gossypol induces death receptor-5 through activation of ROS-ERK-chop pathway and sensitizes colon cancer cells to trail.
Colonic Neoplasms
Human caspase-3 inhibition by Z-tLeu-Asp-H: tLeu(P2) counterbalances Asp(P4) and Glu(P3) specific inhibitor truncation.
Colonic Neoplasms
Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways.
Colonic Neoplasms
Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer.
Colonic Neoplasms
Inducing apoptosis of human colon cancer cells by an IGF-I D domain analogue peptide.
Colonic Neoplasms
Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway.
Colonic Neoplasms
Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest.
Colonic Neoplasms
mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.
Colonic Neoplasms
p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptor DR4.
Colonic Neoplasms
ROS and CHOP are critical for dibenzylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins.
Colonic Neoplasms
ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line.
Colonic Neoplasms
S-Adenosylmethionine and Methylthioadenosine Inhibit Cellular FLICE Inhibitory Protein Expression and Induce Apoptosis in Colon Cancer Cells.
Colonic Neoplasms
Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL).
Colonic Neoplasms
The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway.
Colonic Neoplasms
The TF-antigen binding lectin from Sclerotium rolfsii inhibits growth of human colon cancer cells by inducing apoptosis in vitro and suppresses tumor growth in vivo.
Colorectal Neoplasms
5-Fluorouracil efficiently enhanced apoptosis induced by adenovirus-mediated transfer of caspase-8 in DLD-1 colon cancer cells.
Colorectal Neoplasms
A systems biology approach identifies SART1 as a novel determinant of both 5-fluorouracil and SN38 drug resistance in colorectal cancer.
Colorectal Neoplasms
Antibody against N-terminal domain of phospholipid scramblase 1 induces apoptosis in colorectal cancer cells through the intrinsic apoptotic pathway.
Colorectal Neoplasms
Association between CASP8 -652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study.
Colorectal Neoplasms
Carcinoembryonic antigen inhibits anoikis in colorectal carcinoma cells by interfering with TRAIL-R2 (DR5) signaling.
Colorectal Neoplasms
CASP8 -652 6N del polymorphism and cancer risk: a meta-analysis of 30 case-control studies in 50 112 subjects.
Colorectal Neoplasms
CASP8 -652 6N del polymorphism contributes to colorectal cancer susceptibility: evidence from a meta-analysis.
Colorectal Neoplasms
CASP8 rs3834129 (-652 6N insertion/deletion) Polymorphism and Colorectal Cancer Susceptibility: An Updated Meta-Analysis.
Colorectal Neoplasms
CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population.
Colorectal Neoplasms
Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer.
Colorectal Neoplasms
Colorectal cancer cells induce lymphocyte apoptosis by an endothelial monocyte-activating polypeptide-II-dependent mechanism.
Colorectal Neoplasms
Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells.
Colorectal Neoplasms
Contribution of Caspase-8 Genotypes to Colorectal Cancer Risk in Taiwan.
Colorectal Neoplasms
Correction: Association between CASP8 -652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study.
Colorectal Neoplasms
Efficient drug delivery and induction of apoptosis in colorectal tumors using a death receptor 5-targeted nanomedicine.
Colorectal Neoplasms
Epigallocatechin-3-Gallate Induces Apoptosis as a TRAIL Sensitizer via Activation of Caspase 8 and Death Receptor 5 in Human Colon Cancer Cells.
Colorectal Neoplasms
Genetic polymorphisms of the CASP8 gene promoter may not be associated with colorectal cancer in Han Chinese from southwest China.
Colorectal Neoplasms
Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis.
Colorectal Neoplasms
Independent induction of caspase-8 and cFLIP expression during colorectal carcinogenesis in sporadic and HNPCC adenomas and carcinomas.
Colorectal Neoplasms
Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis.
Colorectal Neoplasms
Isoliquiritigenin-mediated p62/SQSTM1 induction regulates apoptotic potential through attenuation of caspase-8 activation in colorectal cancer cells.
Colorectal Neoplasms
Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas.
Colorectal Neoplasms
Nogo-B (Reticulon-4B) functions as a negative regulator of the apoptotic pathway through the interaction with c-FLIP in colorectal cancer cells.
Colorectal Neoplasms
Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patients.
Colorectal Neoplasms
PEG-liposomal oxaliplatin induces apoptosis in human colorectal cancer cells via Fas/FasL and caspase-8.
Colorectal Neoplasms
Polymorphisms of Caspase 8 and Caspase 9 gene and colorectal cancer susceptibility and prognosis.
Colorectal Neoplasms
Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer.
Colorectal Neoplasms
Prognostic significance of TRAIL signaling molecules in stage II and III colorectal cancer.
Colorectal Neoplasms
Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling.
Colorectal Neoplasms
Synergistic role of Caspase-8 and Caspase-3 expressions: Prognostic and predictive biomarkers in colorectal cancer.
Colorectal Neoplasms
Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancer.
Colorectal Neoplasms
Water extract of brewers' rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/?-catenin downstream signaling pathway in brewers' rice-treated rats with azoxymethane-induced colon carcinogenesis.
Colorectal Neoplasms
[Impact of fragile histidine triad gene transfection on the proliferation and apoptosis of human colorectal cancer cell]
Coronavirus Infections
Porcine hemagglutinating encephalomyelitis virus induces apoptosis in a porcine kidney cell line via caspase-dependent pathways.
COVID-19
Analyzing the potential therapeutic mechanism of Huashi Baidu Decoction on severe COVID-19 through integrating network pharmacological methods.
COVID-19
COVID-19 and male reproductive function: a prospective, longitudinal cohort study.
COVID-19
SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation.
Cowpox
Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance.
Cowpox
Identification of proteins cleaved downstream of caspase activation in monocytes undergoing macrophage differentiation.
Cowpox
Subcellular localization of CrmA: identification of a novel leucine-rich nuclear export signal conserved in anti-apoptotic serpins.
Coxsackievirus Infections
Reduced myocarditis following Coxsackievirus infection in cellular FLICE inhibitory protein--long form-transgenic mice.
Craniocerebral Trauma
Caspase-8 expression and proteolysis in human brain after severe head injury.
Crohn Disease
Caspase-8 regulates TNF-?-induced epithelial necroptosis and terminal ileitis.
Crohn Disease
Deletion of the Casp8 gene in mice results in ileocolitis, gut barrier dysfunction and malassimilation, which can be partially attenuated by inulin or butyrate.
Cryptogenic Organizing Pneumonia
Differential role of the Fas/Fas ligand apoptotic pathway in inflammation and lung fibrosis associated with reovirus 1/L-induced bronchiolitis obliterans organizing pneumonia and acute respiratory distress syndrome.
Cystadenoma
Single CpG island methylation is not sufficient to maintain the silenced expression of CASPASE-8 apoptosis-related gene among women with epithelial ovarian cancer.
Cysts
Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice.
Cysts
Pathways of apoptosis in human autosomal recessive and autosomal dominant polycystic kidney diseases.
Demyelinating Diseases
Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis.
Dengue
FasL/Fas pathway is involved in dengue virus induced apoptosis of the vascular endothelial cells.
Dermatitis, Atopic
Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8.
Diabetes Mellitus
Expression of p53 and caspase-8 in lens epithelial cells of diabetic cataract.
Diabetes Mellitus
Functional variants in cell death pathway genes and risk of pancreatic cancer.
Diabetes Mellitus
Plasma concentration of Caspase-8 is associated with short sleep duration and the risk of incident diabetes mellitus.
Diabetes Mellitus
Type 2 diabetes mellitus induces congenital heart defects in murine embryos by increasing oxidative stress, endoplasmic reticulum stress and apoptosis.
Diabetes Mellitus
[Evaluation of endothelial function and estimation of the degree of apoptosis in patients with metabolic syndrome and non-alcoholic fatty liver disease].
Diabetes Mellitus, Type 2
Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models.
Diabetes Mellitus, Type 2
Type 2 diabetes mellitus induces congenital heart defects in murine embryos by increasing oxidative stress, endoplasmic reticulum stress and apoptosis.
Diabetes Mellitus, Type 2
[Evaluation of endothelial function and estimation of the degree of apoptosis in patients with metabolic syndrome and non-alcoholic fatty liver disease].
Diabetes, Gestational
Identification of potential lncRNAs and co-expressed mRNAs in gestational diabetes mellitus by RNA sequencing.
Diabetic Nephropathies
Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice.
Diabetic Retinopathy
Effects of etanercept on the apoptosis of ganglion cells and expression of Fas, TNF-?, caspase-8 in the retina of diabetic rats.
Diabetic Retinopathy
Expression of p53 and caspase-8 in lens epithelial cells of diabetic cataract.
Diphtheria
Apoptosis of glutamatergic neurons fails to trigger a neurogenic response in the adult neocortex.
Dry Eye Syndromes
Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye.
Dystonia
[Effect of a complex treatment, including glutargin and erbisol on the blood plasma content of protein P53, apoptotic markers of type II, activity of caspases and the level of sCD 117 in patients with autonomic-vascular dystonia]
e2 ubiquitin-conjugating enzyme deficiency
UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.
Encephalitis
Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response.
Encephalitis, Japanese
Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner.
Encephalitis, Japanese
Rana catesbeiana ribonuclease inhibits Japanese encephalitis virus (JEV) replication and enhances apoptosis of JEV-infected BHK-21 cells.
Encephalomyelitis
Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis.
Encephalomyelitis, Autoimmune, Experimental
Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis.
Endometrial Neoplasms
Antioxidants impair anti-tumoral effects of vorinostat, but not anti-neoplastic effects of vorinostat and caspase-8 downregulation.
Endometrial Neoplasms
Cellular mechanisms of growth inhibition of human endometrial cancer cell line by an antagonist of growth hormone-releasing hormone.
Endometrial Neoplasms
Combination of Vorinostat and caspase-8 inhibition exhibits high anti-tumoral activity on endometrial cancer cells.
Endometrial Neoplasms
Effects of Novel Alkyl Pyridine Platinum Complexes on Apoptosis in Ishikawa Endometrial Cancer Cells.
Endometrial Neoplasms
Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells.
Endometrial Neoplasms
In silico analysis reveals a shared immune signature in CASP8-mutated carcinomas with varying correlations to prognosis.
Endometrial Neoplasms
Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population.
Endometrial Neoplasms
Progesterone induces apoptosis by activation of caspase-8 and calcitriol via activation of caspase-9 pathways in ovarian and endometrial cancer cells in vitro.
Endometrial Neoplasms
Receptorial and mitochondrial apoptotic pathways in normal and neoplastic human endometrium.
Endometriosis
Comments on: Gene Polymorphisms in FAS (Rs3740286 and Rs4064) are Involved in Endometriosis Development in Brazilian Women, but not those in CASP8 (rs13416436 and rs2037815).
Endometriosis
Gene Polymorphisms in FAS (Rs3740286 and Rs4064) Are Involved in Endometriosis Development in Brazilian Women, but not those in CASP8 (rs13416436 and rs2037815).
Enteritis
Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis.
Enteritis
STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8.
Epilepsy
Involvement of MnSOD Ala16Val polymorphism in epilepsy: A relationship with seizure type, inflammation, and metabolic syndrome.
Epilepsy, Generalized
Relationship between seizure type, metabolic profile, and inflammatory markers in blood samples of patients with epilepsy.
Esophageal Neoplasms
Enhancement of Apo2L/TRAIL-mediated cytotoxicity in esophageal cancer cells by cisplatin.
Esophageal Neoplasms
Identification of the expression profile of apoptotic esophageal cancer cells by adenoviral-fragile histidine triad treatment.
Esophageal Neoplasms
Smac mimetic compound LCL161 sensitizes esophageal carcinoma cells to radiotherapy by inhibiting the expression of inhibitor of apoptosis protein.
Esophageal Squamous Cell Carcinoma
CASP8 -652 6N del and CASP8 IVS12-19G>A gene polymorphisms and susceptibility/prognosis of ESCC: A case control study in northern Indian population.
Esophageal Squamous Cell Carcinoma
Expression levels of EPHB4, EFNB2 and caspase-8 are associated with clinicopathological features and progression of esophageal squamous cell cancer.
Esophageal Squamous Cell Carcinoma
Identification of a secondary promoter of CASP8 and its related transcription factor PUR?.
Esophageal Squamous Cell Carcinoma
[Expression of Fas, Fas ligand, Fas-associated death domain protein, caspase 8 and mutant P53 protein in esophageal squamous cell carcinoma]
Facial Nerve Injuries
[Facial motoneurons death and caspase regulatory gene expression following facial nerve injury].
Familial Mediterranean Fever
ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis.
Familial Mediterranean Fever
IL-1? and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1? or Caspase-8 in a Mouse Model of Familial Mediterranean Fever.
Fanconi Anemia
Interferon-gamma-induced apoptotic responses of Fanconi anemia group C hematopoietic progenitor cells involve caspase 8-dependent activation of caspase 3 family members.
Fatty Liver
CDKN2A deregulation in fatty liver disease and its accelerative role in the process of lipogenesis.
Fatty Liver
Inhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice.
Fatty Liver
Pinch loss ameliorates obesity, glucose intolerance and fatty liver by modulating adipocyte apoptosis in mice.
Fatty Liver
Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates.
Fetal Diseases
Advances in revealing the molecular targets downstream of oxidative stress-induced proapoptotic kinase signaling in diabetic embryopathy.
Fibrosarcoma
Dynamic quantitative proteomics characterization of TNF-?-induced necroptosis.
Gallbladder Neoplasms
Caspase-8 polymorphisms and risk of gallbladder cancer in a northern Indian population.
Ganglioneuroma
Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.
Ganglioneuroma
Loss of caspase-8 expression in neuroblastoma is related to malignancy and resistance to TRAIL-induced apoptosis.
Gastroesophageal Reflux
[Evaluation of endothelial function and estimation of the degree of apoptosis in patients with metabolic syndrome and non-alcoholic fatty liver disease].
Gastrointestinal Neoplasms
The relationship of CASP 8 polymorphism and cancer susceptibility: a meta-analysis.
Geographic Atrophy
DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.
Glaucoma
A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma.
Glaucoma
Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1? production in acute glaucoma.
Glaucoma
HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-?B pathway in acute glaucoma.
Glaucoma
Kaempferol attenuates retinal ganglion cell death by suppressing NLRP1/NLRP3 inflammasomes and caspase-8 via JNK and NF-?B pathways in acute glaucoma.
Glaucoma
microRNA-21a-5p/PDCD4 axis regulates mesenchymal stem cell-induced neuroprotection in acute glaucoma.
Glaucoma
Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma.
Glioblastoma
?-Hispanolol Induces Apoptosis and Suppresses Migration and Invasion of Glioblastoma Cells Likely via Downregulation of MMP-2/9 Expression and p38MAPK Attenuation.
Glioblastoma
A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma.
Glioblastoma
Accelerated degradation of cFLIPL and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis.
Glioblastoma
Autophagic Degradation of Caspase-8 Protects U87MG Cells Against H2O2-induced Oxidative Stress.
Glioblastoma
C-27-carboxylated oleanane triterpenoids up-regulate TRAIL DISC assembly via p38 MAPK and CHOP-mediated DR5 expression in human glioblastoma cells.
Glioblastoma
Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma.
Glioblastoma
Caspase-8 expression and its Src-dependent phosphorylation on Tyr380 promote cancer cell neoplastic transformation and resistance to anoikis.
Glioblastoma
Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma.
Glioblastoma
Ceramide increases Fas-mediated apoptosis in glioblastoma cells through FLIP down-regulation.
Glioblastoma
CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme.
Glioblastoma
DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas.
Glioblastoma
Fas, FasL, and cleaved caspases 8 and 3 in glioblastomas: A tissue microarray-based study.
Glioblastoma
Heterogeneity of primary glioblastoma cells in the expression of caspase-8 and the response to TRAIL-induced apoptosis.
Glioblastoma
Immunocytochemical detection of members of the caspase cascade of apoptosis in high-grade astrocytomas.
Glioblastoma
Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction.
Glioblastoma
Intracellular cholesterol level regulates sensitivity of glioblastoma cells against temozolomide-induced cell death by modulation of caspase-8 activation via death receptor 5-accumulation and activation in the plasma membrane lipid raft.
Glioblastoma
miR-200a enhances TRAIL-induced apoptosis in gastric cancer cells by targeting A20.
Glioblastoma
N-(4-Hydroxyphenyl) retinamide potentiated paclitaxel for cell cycle arrest and apoptosis in glioblastoma C6 and RG2 cells.
Glioblastoma
N-(4-Hydroxyphenyl)retinamide induced differentiation with repression of telomerase and cell cycle to increase interferon-gamma sensitivity for apoptosis in human glioblastoma cells.
Glioblastoma
Overexpression of FADD and Caspase-8 inhibits proliferation and promotes apoptosis of human glioblastoma cells.
Glioblastoma
Promyelocytic leukemia protein induces apoptosis due to caspase-8 activation via the repression of NF{kappa}B activation in glioblastoma.
Glioblastoma
Urokinase plasminogen activator receptor and/or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells.
Glioma
A peroxisome proliferator-activated receptor-gamma agonist, troglitazone, facilitates caspase-8 and -9 activities by increasing the enzymatic activity of protein-tyrosine phosphatase-1B on human glioma cells.
Glioma
Acid sphingomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells.
Glioma
Adenovirus-mediated transfer of bax with caspase-8 controlled by myelin basic protein promoter exerts an enhanced cytotoxic effect in gliomas.
Glioma
Adenovirus-mediated transfer of caspase-8 augments cell death in gliomas: implication for gene therapy.
Glioma
Adenovirus-mediated transfer of caspase-8 in combination with superrepressor of NF-kappaB drastically induced apoptosis in gliomas.
Glioma
Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells.
Glioma
Caspase-8 gene therapy using the human telomerase reverse transcriptase promoter for malignant glioma cells.
Glioma
Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis.
Glioma
Celastrol enhances TRAIL-induced apoptosis in human glioblastoma via the death receptor pathway.
Glioma
Co-transduction of p27Kip1 strongly augments Fas ligand- and caspase-8-mediated apoptosis in U-373MG glioma cells.
Glioma
Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme.
Glioma
ConBr lectin modulates MAPKs and Akt pathways and triggers autophagic glioma cell death by a mechanism dependent upon caspase-8 activation.
Glioma
Crm-A, bcl-2 and NDGA inhibit CD95L-induced apoptosis of malignant glioma cells at the level of caspase 8 processing.
Glioma
Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt.
Glioma
DNA methylation-mediated caspase-8 downregulation is associated with anti-apoptotic activity and human malignant glioma grade.
Glioma
Effects of microRNA-195 on the Prognosis of Glioma Patients and the Proliferation and Apoptosis of Human Glioma Cells.
Glioma
Enhanced apoptosis following treatment with TRA-8 anti-human DR5 monoclonal antibody and overexpression of exogenous Bax in human glioma cells.
Glioma
Gene therapy using an adenovirus vector for apoptosis-related genes is a highly effective therapeutic modality for killing glioma cells.
Glioma
Human amniotic membrane derived-mesenchymal stem cells induce C6 glioma apoptosis in vivo through the Bcl-2/caspase pathways.
Glioma
Human umbilical cord blood stem cells show PDGF-D-dependent glioma cell tropism in vitro and in vivo.
Glioma
Impact of the DNA methyltransferases expression on the methylation status of apoptosis-associated genes in glioblastoma multiforme.
Glioma
Induction of apoptosis in glioma cells requires cell-to-cell contact with human umbilical cord blood stem cells.
Glioma
Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction.
Glioma
MEK-ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death.
Glioma
MicroRNA-106b-5p boosts glioma tumorigensis by targeting multiple tumor suppressor genes.
Glioma
Molecular mechanisms of TNF-alpha-induced ceramide formation in human glioma cells: P53-mediated oxidant stress-dependent and -independent pathways.
Glioma
Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults.
Glioma
Proteasome mediated degradation of CDC25C and Cyclin B1 in Demethoxycurcumin treated human glioma U87 MG cells to trigger G2/M cell cycle arrest.
Glioma
RNAi-mediated downregulation of MMP-2 activates the extrinsic apoptotic pathway in human glioma xenograft cells.
Glioma
Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation.
Glioma
Suppression of SIRT6 by miR-33a facilitates tumor growth of glioma through apoptosis and oxidative stress resistance.
Glioma
TRAIL induces proliferation of human glioma cells by c-FLIP(L)-mediated activation of ERK1/2.
Glioma
Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells.
Glioma
UMI-77 primes glioma cells for TRAIL-induced apoptosis by unsequestering Bim and Bak from Mcl-1.
Glioma
Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity.
Glomerulonephritis, IGA
Association of BH3 interacting domain death agonist (BID) gene polymorphisms with proteinuria of immunoglobulin A nephropathy.
Glucose Intolerance
Disruption of Adipocyte Caspase 8 Protects Mice from Weight Gain and Glucose Intolerance.
Glucose Intolerance
Pinch loss ameliorates obesity, glucose intolerance and fatty liver by modulating adipocyte apoptosis in mice.
Glucose Intolerance
Short-term Lenalidomide (Revlimid) Administration Ameliorates Cardiomyocyte Contractile Dysfunction in ob/ob Obese Mice.
Goiter, Nodular
[Analysis of Fas, FasL and Caspase-8 expression in thyroid gland in young patients with immune and non-immune thyroid diseases]
Gram-Negative Bacterial Infections
Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster.
Granuloma
Caspase-8 Deficiency Presenting as Late-Onset Multi-Organ Lymphocytic Infiltration with Granulomas in two Adult Siblings.
Graves Disease
[Analysis of Fas, FasL and Caspase-8 expression in thyroid gland in young patients with immune and non-immune thyroid diseases]
Hantavirus Infections
Tula hantavirus infection of Vero E6 cells induces apoptosis involving caspase 8 activation.
Hantavirus Infections
Tula hantavirus triggers pro-apoptotic signals of ER stress in Vero E6 cells.
Head and Neck Neoplasms
Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction.
Head and Neck Neoplasms
Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth.
Head and Neck Neoplasms
Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10.
Head and Neck Neoplasms
Signaling by cell surface death receptors: Alterations in head and neck cancer.
Head and Neck Neoplasms
The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck.
Head and Neck Neoplasms
Translational Genomics and Recent Advances in Oral Squamous Cell Carcinoma.
Head and Neck Neoplasms
Understanding the Role of the Death Receptor 5/FADD/caspase-8 Death Signaling in Cancer Metastasis.
Hearing Loss
Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss.
Hearing Loss
Hearing loss risk and DNA methylation signatures in preschool children following lead and cadmium exposure from an electronic waste recycling area.
Heart Septal Defects, Ventricular
Type 2 diabetes mellitus induces congenital heart defects in murine embryos by increasing oxidative stress, endoplasmic reticulum stress and apoptosis.
Hematologic Neoplasms
Mutational analysis of apoptotic genes in familial aggregation of hematological malignancies.
Hepatitis
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.
Hepatitis
The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer.
Hepatitis B
Activation of extrinsic apoptosis pathway in HCV monoinfected and HIV-HCV coinfected patients, irrespective of liver disease severity.
Hepatitis B
Genetic variants in cell death pathway genes and HBV-related hepatocellular carcinoma among a Chinese Han population.
Hepatitis B
Potential Molecular Mechanisms of Plantain in the Treatment of Gout and Hyperuricemia Based on Network Pharmacology.
Hepatitis C
A bioinformatics investigation into the pharmacological mechanisms of the effect of the Yinchenhao decoction on hepatitis C based on network pharmacology.
Hepatitis C
Hepatitis C Virus Core Protein Inhibits Tumor Necrosis Factor Alpha-Mediated Apoptosis by a Protective Effect Involving Cellular FLICE Inhibitory Protein.
Hepatomegaly
Loss of caspase-8 in hepatocytes accelerates the onset of liver regeneration in mice through premature nuclear factor kappa B activation.
Herpes Simplex
Mapping herpes simplex virus type 1 latency-associated transcript sequences that protect from apoptosis mediated by a plasmid expressing caspase-8.
Herpes Simplex
The bovine viral diarrhea virus (BVDV) NS3 protein, when expressed alone in mammalian cells, induces apoptosis which correlates with caspase-8 and caspase-9 activation.
Herpes Simplex
The equine arteritis virus induces apoptosis via caspase-8 and mitochondria-dependent caspase-9 activation.
Herpes Simplex
The R1 subunit of herpes simplex virus ribonucleotide reductase protects cells against apoptosis at, or upstream of, caspase-8 activation.
Herpes Simplex
The Ribonucleotide Reductase R1 Subunits of Herpes Simplex Virus 1 and 2 Protect Cells against Poly(I {middle dot} C)-Induced Apoptosis.
Herpes Simplex
The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNF?- and FasL-induced apoptosis by interacting with caspase-8.
Herpes Zoster
Lactational exposure of phthalate causes long-term disruption in testicular architecture by altering tight junctional and apoptotic protein expression in Sertoli cells of first filial generation pubertal Wistar rats.
Herpesviridae Infections
Remarkably Robust Antiviral Immune Response despite Combined Deficiency in Caspase-8 and RIPK3.
Histiocytosis
Immunohistochemical detection of the apoptosis-related proteins FADD, FLICE, and FLIP in Langerhans cell histiocytosis.
Histiocytosis, Langerhans-Cell
Immunohistochemical detection of the apoptosis-related proteins FADD, FLICE, and FLIP in Langerhans cell histiocytosis.
HIV Infections
Caspase 1 and caspase 8 in HIV infected patients with and without tuberculosis.
HIV Infections
HIV gp120 induces, NF-kappaB dependent, HIV replication that requires procaspase 8.
HIV Infections
HIV Protease Cleavage of Procaspase 8 is Necessary for Death of HIV-Infected Cells.
HIV Infections
Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)- and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3.
Hodgkin Disease
Expression of c-FLIP is primarily detected in diffuse large B-cell lymphoma and Hodgkin's lymphoma and correlates with lack of caspase 8 activation.
Hodgkin Disease
Frequent nuclear localization of ICAD and cytoplasmic co-expression of caspase-8 and caspase-3 in human lymphomas.
Hodgkin Disease
The fully human anti-CD30 antibody 5F11 activates NF-{kappa}B and sensitizes lymphoma cells to bortezomib-induced apoptosis.
Huntington Disease
Caspase-8 is required for cell death induced by expanded polyglutamine repeats.
Huntington Disease
cDNA microarray-based identification of genes and pathways associated with oxaliplatin resistance.
Huntington Disease
Increased caspase-2, calpain activations and decreased mitochondrial complex II activity in cells expressing exogenous huntingtin exon 1 containing CAG repeat in the pathogenic range.
Huntington Disease
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
Hydrocephalus
Evidence for the involvement of caspases in establishing proper cerebrospinal fluid hydrodynamics.
Hyperalgesia
A single subcutaneous injection of ozone prevents allodynia and decreases the over-expression of pro-inflammatory caspases in the orbito-frontal cortex of neuropathic mice.
Hyperalgesia
Peripheral noxious stimulation reduces withdrawal threshold to mechanical stimuli after spinal cord injury: role of tumor necrosis factor alpha and apoptosis.
Hyperemia
Venous congestion induces mucosal apoptosis via tumor necrosis factor-alpha-mediated cell death in the rat small intestine.
Hyperglycemia
Somatostatin protects photoreceptor cells against high glucose-induced apoptosis.
Hyperlipidemias
Effect of folic acid and vitamin B12 on the expression of PPAR?, caspase-3 and caspase-8 mRNA in the abdominal aortas of rats with hyperlipidemia.
Hyperparathyroidism, Primary
Caspase 8 and menin expressions are not correlated in human parathyroid tumors.
Hypersensitivity
Gene expression changes in peripheral blood mononuclear cells in occupational exposure to nickel.
Hypersensitivity
p53/T-antigen complex disruption in T-antigen transformed NIH3T3 fibroblasts exposed to oxidative stress: correlation with the appearance of a Fas/APO-1/CD95 dependent, caspase independent, necrotic pathway.
Hypersensitivity
Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis.
Hypertension
Energy deficit as a possible factor for the induction of caspase-dependent apoptosis in left ventricular myocardial cells during genetically determined and secondary arterial hypertension.
Hyperthyroidism
Hyperthyroidism induces apoptosis in rat liver through activation of death receptor-mediated pathways.
Hypoxia, Brain
Temporal Changes in Caspase-1 and Caspase-8 Activities Following Brain Hypoxia With and Without Src kinase Inhibition in a Piglet Animal Model.
Ileitis
Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn's Disease-Like Inflammation.
Ileitis
FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.
Immune System Diseases
Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder.
Immune System Diseases
Transcriptome reveals the important role of metabolic imbalances, immune disorders and apoptosis in the treatment of Procambarus clarkii at super high temperature.
Infarction, Middle Cerebral Artery
Association between blood caspase-8 levels and mortality of patients with malignant middle cerebral artery infarction.
Infarction, Middle Cerebral Artery
Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat.
Infarction, Middle Cerebral Artery
FasL shedding is reduced by hypothermia in experimental stroke.
Infarction, Middle Cerebral Artery
FLIP(L) protects neurons against in vivo ischemia and in vitro glucose deprivation-induced cell death.
Infarction, Middle Cerebral Artery
Licorice Pretreatment Protects Against Brain Damage Induced by Middle Cerebral Artery Occlusion in Mice.
Infarction, Middle Cerebral Artery
Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways.
Infarction, Middle Cerebral Artery
Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke.
Infarction, Middle Cerebral Artery
Tanshinone IIA attenuates the cerebral ischemic injury-induced increase in levels of GFAP and of caspases-3 and -8.
Infections
A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1? Release in Response to a Pathogenic Fungus.
Infections
A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase-8.
Infections
Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death.
Infections
Adenoviral-mediated transfer of p53 gene enhances TRAIL-induced apoptosis in human hepatocellular carcinoma cells.
Infections
Apoptosis in liver during malaria: role of oxidative stress and implication of mitochondrial pathway.
Infections
Bovine ephemeral fever virus-induced apoptosis requires virus gene expression and activation of Fas and mitochondrial signaling pathway.
Infections
Bovine herpes virus type 1 induces apoptosis through Fas-dependent and mitochondria-controlled manner in Madin-Darby bovine kidney cells.
Infections
c-FLIP-Short reduces type I interferon production and increases viremia with coxsackievirus B3.
Infections
Canine distemper virus induces apoptosis through caspase-3 and -8 activation in vero cells.
Infections
Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.
Infections
Caspase-8 activity is part of the BeWo trophoblast cell defense mechanisms against Trypanosoma cruzi infection.
Infections
Caspase-8 activity prevents type 2 cytokine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection.
Infections
Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells.
Infections
Caspase-8 and caspase-9 mediate thymocyte apoptosis in Trypanosoma cruzi acutely infected mice.
Infections
Caspase-8 and FLIP regulate RIG-I/MDA5-induced innate immune host responses to picornaviruses.
Infections
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
Infections
Caspase-8 Deficiency Presenting as Late-Onset Multi-Organ Lymphocytic Infiltration with Granulomas in two Adult Siblings.
Infections
Caspase-8 gene transduction augments radiation-induced apoptosis in DLD-1 cells.
Infections
Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against Toxoplasma gondii.
Infections
Caspase-8-dependent control of NK- and T cell responses during cytomegalovirus infection.
Infections
CCR5 mediates Fas- and caspase-8 dependent apoptosis of both uninfected and HIV infected primary human CD4 T cells.
Infections
Characterization of Apoptosis Pathways (Intrinsic and Extrinsic) in Lymphoid Tissues of Calves Inoculated with Non-cytopathic Bovine Viral Diarrhoea Virus Genotype-1.
Infections
Classical swine fever virus infection protects aortic endothelial cells from pIpC-mediated apoptosis.
Infections
Comparative transcriptome analysis reveals the role of p53 signalling pathway during red-spotted grouper nervous necrosis virus infection in Lateolabrax japonicus brain cells.
Infections
Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection.
Infections
Coxsackievirus A16 infection induces neural cell and non-neural cell apoptosis in vitro.
Infections
Cyprinid Herpesvirus 2 miR-C12 Attenuates Virus-Mediated Apoptosis and Promotes Virus Propagation by Targeting Caspase 8.
Infections
Dendritic cell-induced apoptosis of human cytomegalovirus-infected fibroblasts promotes cross-presentation of pp65 to CD8+ T cells.
Infections
Dengue virus infection of erythroid precursor cells is modulated by both thalassemia trait status and virus adaptation.
Infections
Distinct Immune Imprints of Post-Liver Transplantation Hepatitis C Persist Despite Viral Clearance.
Infections
Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis.
Infections
Early apoptosis-related changes triggered by HSV-1 in individual neuronlike cells.
Infections
Edwardsiella piscicida type III protein EseJ suppresses apoptosis through down regulating type 1 fimbriae, which stimulate the cleavage of caspase-8.
Infections
Effects of dietary monocalcium phosphate supplementation on the anti-oxidative capacity, anti-bacteria function in immune organs of obscure puffer (Takifugu obscurus) after infection with Aeromonas hydrophila.
Infections
Elevated prostaglandin E2 post-bone marrow transplant mediates interleukin-1?-related lung injury.
Infections
Enterovirus 71 induces apoptosis by directly modulating the conformational activation of pro-apoptotic protein Bax.
Infections
Escherichia coli induces apoptosis in human monocytic U937 cells through the Fas/FasL signaling pathway.
Infections
ExoS of Pseudomonas aeruginosa induces apoptosis through a Fas receptor/caspase 8-independent pathway in HeLa cells.
Infections
Fas-associating death domain protein overexpression induces apoptosis in lung cancer cells.
Infections
FasL/Fas pathway is involved in dengue virus induced apoptosis of the vascular endothelial cells.
Infections
Hepatitis C virus infection of T cells inhibits proliferation and enhances fas-mediated apoptosis by down-regulating the expression of CD44 splicing variant 6.
Infections
Hepatocyte expression of TRAIL pathway regulators correlates with histopathological and clinical parameters in chronic HCV infection.
Infections
HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells.
Infections
Human Cytomegalovirus Stimulates Monocyte-to-Macrophage Differentiation via the Temporal Regulation of Caspase 3.
Infections
Identification and characterization of caspases genes in rainbow trout (Oncorhynchus mykiss) and their expression profiles after Aeromonas salmonicida and Vibrio anguillarum infection.
Infections
Identification and functional characterization of three caspases in Takifugu obscurus in response to bacterial infection.
Infections
In vitro Bartonella quintana infection modulates the programmed cell death and inflammatory reaction of endothelial cells.
Infections
In vivo and in vitro activation of caspase-8 and -3 associated with Helicobacter pylori infection.
Infections
Induction of apoptosis in SSN-1cells by Snakehead Fish Vesiculovirus (SHVV) via Matrix protein dependent intrinsic pathway.
Infections
Induction of CCL20 production by Kaposi's sarcoma-associated herpesvirus: role of viral FLICE inhibitory protein K13-induced NF-{kappa}B activation.
Infections
Induction of cell cycle arrest and apoptosis by BCG infection in cultured human bronchial airway epithelial cells.
Infections
Infected cell killing by HIV-1 protease promotes NF-kappaB dependent HIV-1 replication.
Infections
Influenza Induces ER Stress, Caspase-12- Dependent Apoptosis and JNK Mediated TGF-{beta} Release in Lung Epithelial Cells.
Infections
Inhibition of caspase-8 activity promotes protective Th1- and Th2-mediated immunity to Leishmania major infection.
Infections
Inhibition of caspase-8 activity reduces IFN-gamma expression by T cells from Leishmania major infection.
Infections
Inhibitory Effect of Lentivirus-Mediated Gag-Caspase-8 on the Growth of HER-2-Overexpressing Primary Human Breast Cancer Cells.
Infections
Involvement of clip-domain serine protease in the anti-Vibrio immune response of abalone (Haliotis discus hannai)-Molecular cloning, characterization and functional analysis.
Infections
Involvement of the PI3K and ERK signaling pathways in largemouth bass virus-induced apoptosis and viral replication.
Infections
iTRAQ-based proteomic profile analysis of ISKNV-infected CPB cells with emphasizing on glucose metabolism, apoptosis and autophagy pathways.
Infections
Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner.
Infections
Lactobacillus acidophilus S-layer protein-mediated inhibition of PEDV-induced apoptosis of Vero cells.
Infections
Modulation of apoptosis by caprine herpesvirus 1 infection in a neuronal cell line.
Infections
Molecular cloning of sea bass (Dicentrarchus labrax L.) caspase-8 gene and its involvement in Photobacterium damselae ssp. piscicida triggered apoptosis.
Infections
Mouse cytomegalovirus M36 and M45 death suppressors cooperate to prevent inflammation resulting from antiviral programmed cell death pathways.
Infections
Mutagenesis and functional analysis of the bacterial arginine glycosyltransferase effector NleB1 from enteropathogenic Escherichia coli.
Infections
Mycoplasma synoviae induces upregulation of apoptotic genes, secretion of nitric oxide and appearance of an apoptotic phenotype in infected chicken chondrocytes.
Infections
Necroptosis of Splenic Macrophages Induced by Streptococcus gallolyticus subsp. pasteurianus.
Infections
Nontuberculous Mycobacteria Persistence in a Cell Model Mimicking Alveolar Macrophages.
Infections
Porcine Epidemic Diarrhea Virus Infection Induces Caspase-8 mediated G3BP1 Cleavage and Subverts Stress Granules to Promote Viral Replication.
Infections
Postpartum disseminated HSV-1 infection with hemophagocytic lymphohistiocytosis and fulminant neonatal herpes infection.
Infections
Protection against CD95-induced apoptosis by chlamydial infection at a mitochondrial step.
Infections
Reovirus-induced neuronal apoptosis is mediated by caspase 3 and is associated with the activation of death receptors.
Infections
Responses of murine and human macrophages to leptospiral infection: a study using comparative array analysis.
Infections
Restoration of TRAIL-induced apoptosis in a caspase-8-deficient neuroblastoma cell line by stable re-expression of caspase-8.
Infections
Restriction of H1N1 influenza virus infection by selenium nanoparticles loaded with ribavirin via resisting caspase-3 apoptotic pathway.
Infections
Selective apoptotic behaviour of bovine herpesvirus 1 in an epithelial-like microenvironment.
Infections
Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity.
Infections
sHLA-G Involved in the Apoptosis of Decidual Natural Killer Cells Following Toxoplasma gondii Infection.
Infections
Some findings of FADD knockdown in inhibition of HIV-1 replication in Jurkat cells and PBMCs.
Infections
Staphylococcus aureus - induced tumor necrosis factor - related apoptosis - inducing ligand expression mediates apoptosis and caspase-8 activation in infected osteoblasts.
Infections
STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8.
Infections
Study of programmed cell death in bovine herpesvirus 1 infected MDBK cells and the possible role of nitric oxide in this process.
Infections
Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.
Infections
Swine acute diarrhea syndrome coronavirus-induced apoptosis is caspase- and cyclophilin D- dependent.
Infections
The apoptotic pathway triggered by the Fhit protein in lung cancer cell lines is not affected by Bcl-2 or Bcl-x(L) overexpression.
Infections
The combined risks of reduced or increased function variants in cell death pathway genes differentially influence cervical cancer risk and herpes simplex virus type 2 infection among black Africans and the Mixed Ancestry population of South Africa.
Infections
The human caspase-8 promoter sustains basal activity through SP1 and ETS-like transcription factors and can be up-regulated by a p53-dependent mechanism.
Infections
The human cytomegalovirus UL36 gene controls caspase-dependent and -independent cell death programs activated by infection of monocytes differentiating to macrophages.
Infections
The non-receptor tyrosine kinase Tec controls assembly and activity of the noncanonical caspase-8 inflammasome.
Infections
The Ribonucleotide Reductase R1 Subunits of Herpes Simplex Virus 1 and 2 Protect Cells against Poly(I {middle dot} C)-Induced Apoptosis.
Infections
The Toxoplasma gondii ME-49 strain upregulates levels of A20 that inhibit NF-?B activation and promotes apoptosis in human leukaemia T-cell lines.
Infections
The Viral Tegument Protein pp65 Impairs Transcriptional Upregulation of IL-1? by Human Cytomegalovirus through Inhibition of NF-kB Activity.
Infections
Theiler's murine encephalomyelitis virus induces apoptosis in gamma interferon-activated M1 differentiated myelomonocytic cells through a mechanism involving tumor necrosis factor alpha (TNF-alpha) and TNF-alpha-related apoptosis-inducing ligand.
Infections
TNF-? is involved in apoptosis triggered by grass carp reovirus infection in vitro.
Infections
Transmissible gastroenteritis virus infection induces apoptosis through FasL- and mitochondria-mediated pathways.
Infections
Tumor suppressor in lung cancer-1 (TSLC1) mediated by dual-regulated oncolytic adenovirus exerts specific antitumor actions in a mouse model.
Infections
Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers.
Infections
Vesicular stomatitis viruses expressing wild-type or mutant M proteins activate apoptosis through distinct pathways.
Infections
Wild-type p53 induced sensitization of mutant p53 TNF-resistant cells: role of caspase-8 and mitochondria.
Infections
[Antagonism of baicalin on cell cyclical distribution and cell apoptosis in A549 cells infected with influenza A (H1N1) virus].
Infertility, Male
Elevation of autophagy rescues spermatogenesis by inhibiting apoptosis of mouse spermatocytes
Infertility, Male
Polymorphisms in cell death pathway genes are associated with altered sperm apoptosis and poor semen quality.
Inflammatory Bowel Diseases
Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8.
Influenza, Human
Influenza A Virus and Influenza B Virus Can Induce Apoptosis via Intrinsic or Extrinsic Pathways and Also via NF-?B in a Time and Dose Dependent Manner.
Influenza, Human
[Antagonism of baicalin on cell cyclical distribution and cell apoptosis in A549 cells infected with influenza A (H1N1) virus].
Insulin Resistance
MiR-150 deficiency ameliorated hepatosteatosis and insulin resistance in nonalcoholic fatty liver disease via targeting CASP8 and FADD-like apoptosis regulator.
Insulinoma
Menin-mediated Caspase 8 Expression in Suppressing Multiple Endocrine Neoplasia Type 1.
Intervertebral Disc Degeneration
Expression of TRAIL and the death receptors DR4 and DR5 correlates with progression of degeneration in human intervertebral disks.
Intracranial Arteriovenous Malformations
Neuronal expression of Fas-associated death domain protein and caspase-8 in the perinidal parenchyma of cerebral arteriovenous malformations.
Iron Overload
Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload.
Ischemic Stroke
Association between blood caspase-8 levels and mortality of patients with malignant middle cerebral artery infarction.
Ischemic Stroke
FADD (Fas-Associated Protein With Death Domain), Caspase-3, and Caspase-8 and Incidence of Ischemic Stroke.
Ischemic Stroke
Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke.
Ischemic Stroke
Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke.
Kashin-Beck Disease
[Expression of Caspase-8 and Bcl-2 in the cartilage loose bodies in patients with Kashin-Beck disease].
Keloid
MiR-21 regulates the apoptosis of keloid fibroblasts by caspase-8 and mitochondrial-mediated apoptotic signaling pathway via targeting FasL.
Keloid
Topical application of imiquimod 5% cream to keloids alters expression genes associated with apoptosis.
Kidney Neoplasms
Discovery of CASP8 as a potential biomarker for high-risk prostate cancer through a high-multiplex immunoassay.
Kidney Neoplasms
Metformin-induced apoptosis facilitates degradation of the cellular caspase 8 (FLICE)-like inhibitory protein through a caspase-dependent pathway in human renal cell carcinoma A498 cells.
Laryngeal Neoplasms
[Apoptosis mechanism of taxol combined with resveratrol on human laryngeal carcinoma Hep-2 cells].
Latent Infection
Stable expression of human immunodeficiency virus type 1 Nef confers resistance against Fas-mediated apoptosis.
Leiomyoma
A novel selective progesterone receptor modulator asoprisnil activates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated signaling pathway in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells.
Leprosy
Influence of Genetic Ancestry on INDEL Markers of NFK?1, CASP8, PAR1, IL4 and CYP19A1 Genes in Leprosy Patients.
Leukemia
23-Hydroxyursolic Acid Isolated from the Stem Bark of Cussonia bancoensis Induces Apoptosis through Fas/Caspase-8-Dependent Pathway in HL-60 Human Promyelocytic Leukemia Cells.
Leukemia
Activation of p38 mitogen-activated protein kinase during ent-11alpha-hydroxy-16-kauren-15-one-induced apoptosis in human leukemia HL-60 cells.
Leukemia
Alternative Fas-mediated cell death pathway is dependent on the different cleavage patterns of procaspase-8.
Leukemia
An agonistic monoclonal antibody against DR5 induces ROS production, sustained JNK activation and Endo G release in Jurkat leukemia cells.
Leukemia
Apoptogenic activity of auraptene of Zanthoxylum schinifolium toward human acute leukemia Jurkat T cells is associated with ER stress-mediated caspase-8 activation that stimulates mitochondria-dependent or -independent caspase cascade.
Leukemia
Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis.
Leukemia
Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase.
Leukemia
Breaking chemoresistance and radioresistance with [213Bi]anti-CD45 antibodies in leukemia cells.
Leukemia
Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells.
Leukemia
Caspase-8 mediates mitochondrial release of pro-apoptotic proteins in a manner independent of its proteolytic activity in apoptosis induced by the protein synthesis inhibitor acetoxycycloheximide in human leukemia Jurkat cells.
Leukemia
Caspase-8 Preferentially Senses the Apoptosis-Inducing Action of NG-18, A Gambogic Acid Derivative, in Human Leukemia HL-60 Cells.
Leukemia
CD44 ligation with A3D8 antibody induces apoptosis in acute myeloid leukemia cells through binding to CD44s and forming lipid rafts.
Leukemia
Compound K induced apoptosis via endoplasmic reticulum Ca2+ release through ryanodine receptor in human lung cancer cells.
Leukemia
Dehydrocostus lactone enhances tumor necrosis factor-alpha-induced apoptosis of human leukemia HL-60 cells.
Leukemia
Dietary docosahexaenoic acid decreased lipid accumulation via inducing adipocytes apoptosis of grass carp, Ctenopharygodon idella.
Leukemia
Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP).
Leukemia
Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells.
Leukemia
Dup-697, a specific COX-2 inhibitor, suppresses growth and induces apoptosis on K562 leukemia cells by cell-cycle arrest and caspase-8 activation.
Leukemia
Effects of AG490 and S3I-201 on regulation of the JAK/STAT3 signaling pathway in relation to angiogenesis in TRAIL-resistant prostate cancer cells in vitro.
Leukemia
Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7.
Leukemia
Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cells.
Leukemia
Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D.
Leukemia
Glycogen synthase kinase-3beta mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia.
Leukemia
Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines.
Leukemia
Involvement of caspase-8 in chemotherapy-induced apoptosis of patient derived leukemia cell lines independent of the death receptor pathway and downstream from mitochondria.
Leukemia
Involvement of p38 and c-Jun N-terminal protein kinase in cardiotoxin III-induced apoptosis of K562 cells.
Leukemia
Kalopanaxsaponin A induces apoptosis in human leukemia U937 cells through extracellular Ca2+ influx and caspase-8 dependent pathways.
Leukemia
Methylene chloride fraction of Scutellaria barbata induces apoptosis in human U937 leukemia cells via the mitochondrial signaling pathway.
Leukemia
Molecular mechanism of satratoxin-induced apoptosis in HL-60 cells: activation of caspase-8 and caspase-9 is involved in activation of caspase-3.
Leukemia
NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells.
Leukemia
PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells.
Leukemia
Promyelocytic leukemia protein induces apoptosis due to caspase-8 activation via the repression of NF{kappa}B activation in glioblastoma.
Leukemia
Radiation-induced apoptosis is independent of caspase-8 but dependent on cytochrome c and the caspase-9 cascade in human leukemia HL60 cells.
Leukemia
Resveratrol enhances anticancer effects of paclitaxel in HepG2 human liver cancer cells.
Leukemia
Retinoic acid-induced CD38 antigen promotes leukemia cells attachment and interferon-gamma/interleukin-1beta-dependent apoptosis of endothelial cells: implications in the etiology of retinoic acid syndrome.
Leukemia
Role of death receptor and mitochondrial pathways in conventional chemotherapy drug induction of apoptosis.
Leukemia
Sann-Joong-Kuey-Jian-Tang decreases the protein expression of Mcl?1 and TCTP and increases that of TNF-? and Bax in BxPC?3 pancreatic carcinoma cells.
Leukemia
Selective induction of apoptosis through activation of caspase-8 in human leukemia cells (Jurkat) by dandelion root extract.
Leukemia
Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor ?-induced necroptosis.
Leukemia
Sorafenib inhibited cell growth through the MEK/ERK signaling pathway in acute promyelocytic leukemia cells.
Leukemia
Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs.
Leukemia
Spontaneous neutrophil apoptosis and regulation of cell survival by granulocyte macrophage-colony stimulating factor.
Leukemia
Sulfuretin from heartwood of Rhus verniciflua triggers apoptosis through activation of Fas, Caspase-8, and the mitochondrial death pathway in HL-60 human leukemia cells.
Leukemia
Targeting BCR Tyrosine177 site with novel SH2-DED causes selective leukemia cell death in vitro and in vivo.
Leukemia
The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2alpha in leukemia cells.
Leukemia
The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells.
Leukemia
The novel triterpenoid CDDO and its derivatives induce apoptosis by disruption of intracellular redox balance.
Leukemia
Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells.
Leukemia
TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells.
Leukemia
Viscum articulatum Burm. f. aqueous extract exerts antiproliferative effect and induces cell cycle arrest and apoptosis in leukemia cells.
Leukemia
YM155 induces caspase-8 dependent apoptosis through downregulation of survivin and Mcl-1 in human leukemia cells.
Leukemia
[Effects of SODD and survivin on leukemia cell apoptosis induced by chemotherapeutic drugs]
Leukemia, B-Cell
Apoptosis in meningoencephalitis of Angiostrongylus cantonensis-infected mice.
Leukemia, B-Cell
Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice.
Leukemia, B-Cell
Dietary docosahexaenoic acid decreased lipid accumulation via inducing adipocytes apoptosis of grass carp, Ctenopharygodon idella.
Leukemia, Large Granular Lymphocytic
Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation.
Leukemia, Lymphocytic, Chronic, B-Cell
Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma.
Leukemia, Lymphocytic, Chronic, B-Cell
PI3-kinase regulates survival of chronic lymphocytic leukemia B-cells by preventing caspase 8 activation.
Leukemia, Lymphocytic, Chronic, B-Cell
Possible Role of Polymorphisms in TNFA, NFKB1, and CASP8 Gene Promoter Areas in the Development of Chronic Lymphocytic Leukemia.
Leukemia, Lymphoid
Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation.
Leukemia, Myeloid
A new matrix metalloproteinase inhibitor SI-27 induces apoptosis in several human myeloid leukemia cell lines and enhances sensitivity to TNF alpha-induced apoptosis.
Leukemia, Myeloid
Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells.
Leukemia, Myeloid
Cryptotanshinone enhances TNF-?-induced apoptosis in chronic myeloid leukemia KBM-5 cells.
Leukemia, Myeloid
Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4.
Leukemia, Myeloid, Acute
Caspase-8 dependent apoptosis induction in malignant myeloid cells by TLR stimulation in the presence of IFN-alpha.
Leukemia, Myeloid, Acute
Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.
Leukemia, Myeloid, Acute
Hispolon Induces Apoptosis through JNK1/2-mediated Activation of a Caspase-8, -9, and -3-dependent Pathway in Acute Myeloid Leukemia (AML) Cells and Inhibits AML Xenograft Tumor Growth in Vivo.
Leukemia, Myeloid, Acute
The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.
Leukemia, Promyelocytic, Acute
CD44 ligation with A3D8 antibody induces apoptosis in acute myeloid leukemia cells through binding to CD44s and forming lipid rafts.
Leukemia-Lymphoma, Adult T-Cell
Lactacystin activates FLICE (caspase 8) protease and induces apoptosis in Fas-resistant adult T-cell leukemia cell lines.
Leukemia-Lymphoma, Adult T-Cell
Possible attenuation of fas-mediated signaling by dominant expression of caspase-8 aberrant isoform in adult T-cell leukemia cells.
Leukemia-Lymphoma, Adult T-Cell
Sensitivity of adult T-cell leukaemia lymphoma cells to tumour necrosis factor-related apoptosis-inducing ligand.
Leukoplakia
Study of Caspase 8 mutation in oral cancer and adjacent precancer tissues and implication in progression.
Leukoplakia, Oral
[Expressions of receptor-interacting protein and caspase-8 in oral squamous cell carcinoma and oral precancerous lesions.]
Lichen Planus, Oral
[Expression of caspase-8, receptor interacting protein and nuclear factor-kappaBp65 in oral lichen planus.]
Lichen Planus, Oral
[Expressions of receptor-interacting protein and caspase-8 in oral squamous cell carcinoma and oral precancerous lesions.]
Liver Cirrhosis
A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis.
Liver Cirrhosis, Biliary
Activation of extrinsic apoptosis pathway in HCV monoinfected and HIV-HCV coinfected patients, irrespective of liver disease severity.
Liver Cirrhosis, Biliary
Inactivation of caspase 8 in liver parenchymal cells confers protection against murine obstructive cholestasis.
Liver Diseases
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.
Liver Diseases
Highlight report: caspase 8 as a therapeutic target in chronic liver disease.
Liver Diseases
MiR-150 deficiency ameliorated hepatosteatosis and insulin resistance in nonalcoholic fatty liver disease via targeting CASP8 and FADD-like apoptosis regulator.
Liver Diseases
Roles of Fas/Fasl, Bcl-2/Bax, and Caspase-8 in rat nonalcoholic fatty liver disease pathogenesis.
Liver Failure
Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation.
Liver Failure
Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB.
Liver Failure, Acute
Characterization of pro-apoptotic effect of liver failure plasma on primary human hepatocytes and its modulation by molecular adsorbent recirculation system therapy.
Liver Failure, Acute
The role of death effector domain (DED)-containing proteins in acute oxidative cell injury in hepatocytes.
Liver Neoplasms
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Liver Neoplasms
Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cancer.
Liver Neoplasms
In vitro cytotoxicity and pro-apoptotic activity of phycocyanin nanoparticles from Ulva lactuca (Chlorophyta) algae.
Liver Neoplasms
The bioactive ingredients in Actinidia chinensis Planch. Inhibit liver cancer by inducing apoptosis.
Lung Injury
Direct Peritoneal Resuscitation Reduces Lung Injury and Caspase 8 Activity in Brain Death.
Lung Injury
Ethanol metabolism, oxidative stress, and endoplasmic reticulum stress responses in the lungs of hepatic alcohol dehydrogenase deficient deer mice after chronic ethanol feeding.
Lung Injury
Penehyclidine hydrochloride exerts protective effects in rats with acute lung injury via the Fas/FasL signaling pathway.
Lung Neoplasms
A combination of functional polymorphisms in the CASP8, MMP1, IL10 and SEPS1 genes affects risk of non-small cell lung cancer.
Lung Neoplasms
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers.
Lung Neoplasms
Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer.
Lung Neoplasms
Activation-induced cell death of memory CD8+ T cells from pleural effusion of lung cancer patients is mediated by the type II Fas-induced apoptotic pathway.
Lung Neoplasms
Alpha-tocopheryl succinate potentiates the paclitaxel-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells.
Lung Neoplasms
Alterations of Fas-pathway genes associated with nodal metastasis in non-small cell lung cancer.
Lung Neoplasms
Altered expression profile of apoptosis-related molecules correlated with clinicopathological factors in non-small-cell lung cancer.
Lung Neoplasms
Apoptosis by gemcitabine in non-small cell lung cancer cell line KNS62 is induced downstream of caspase 8 and is profoundly blocked by Bcl-xL over-expression.
Lung Neoplasms
Apoptosis-Inducing Activity of Marine Sponge Haliclona sp. Extracts Collected from Kosrae in Nonsmall Cell Lung Cancer A549 Cells.
Lung Neoplasms
Artemisinin induces A549 cell apoptosis dominantly via a reactive oxygen species-mediated amplification activation loop among caspase-9, -8 and -3.
Lung Neoplasms
Association Between CASP8 and CASP10 Polymorphisms and Toxicity Outcomes with Platinum-Based Chemotherapy in Chinese Patients with Non-Small Cell Lung Cancer.
Lung Neoplasms
Association of CASP8 polymorphisms and cancer susceptibility: A meta-analysis.
Lung Neoplasms
c-FLIP Downregulation Contributes to Apoptosis Induction by the Novel Synthetic Triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in Human Lung Cancer Cells.
Lung Neoplasms
c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells.
Lung Neoplasms
Calmodulin inhibition contributes to sensitize TRAIL-induced apoptosis in human lung cancer H1299 cells.
Lung Neoplasms
Caspase-8 knockdown suppresses apoptosis, while induces autophagy and chemo-sensitivity in non-small cell lung cancer cells.
Lung Neoplasms
Cassia alata leaf extract induces cytotoxicity in A549 lung cancer cells via a mechanism that is caspase 8 dependent.
Lung Neoplasms
Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer.
Lung Neoplasms
Colicin N Mediates Apoptosis and Suppresses Integrin-Modulated Survival in Human Lung Cancer Cells.
Lung Neoplasms
Combined treatment with the Cox-2 inhibitor niflumic acid and PPAR? ligand ciglitazone induces ER stress/caspase-8-mediated apoptosis in human lung cancer cells.
Lung Neoplasms
CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis.
Lung Neoplasms
Enhancement of Apo2L/TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis in non-small cell lung cancer cell lines by chemotherapeutic agents without correlation to the expression level of cellular protease caspase-8 inhibitory protein.
Lung Neoplasms
Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cells.
Lung Neoplasms
Fibronectin protects lung cancer cells against docetaxel-induced apoptosis by promoting Src and caspase-8 phosphorylation.
Lung Neoplasms
Gefitinib induces cytoplasmic translocation of the CDK inhibitor p27 and its binding to a cleaved intermediate of caspase 8 in non-small cell lung cancer cells.
Lung Neoplasms
Gemcitabine sensitizes lung cancer cells to Fas/FasL system-mediated killing.
Lung Neoplasms
Hydroxycamptothecin-Loaded Fe(3) O(4) Nanoparticles Induce Human Lung Cancer Cell Apoptosis through Caspase-8 Pathway Activation and Disrupt Tight Junctions.
Lung Neoplasms
Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung cancer A549 cells.
Lung Neoplasms
Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification.
Lung Neoplasms
MicroRNA-145 replacement effect on growth and migration inhibition in lung cancer cell line.
Lung Neoplasms
MicroRNA-296-5p Promotes Invasiveness through Downregulation of Nerve Growth Factor Receptor and Caspase-8.
Lung Neoplasms
Nimesulide, a selective COX-2 inhibitor, acts synergistically with ionizing radiation against A549 human lung cancer cells through the activation of caspase-8 and caspase-3.
Lung Neoplasms
Polymorphisms in the Gene Encoding Caspase 8 May Predict the Response to First-Line Platinum-Based Chemotherapy in Locally Advanced or Advanced Non-Small-Cell Lung Cancer.
Lung Neoplasms
Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese.
Lung Neoplasms
Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation.
Lung Neoplasms
Small Molecular TRAIL Inducer ONC201 Induces Death in Lung Cancer Cells: A Preclinical Study.
Lung Neoplasms
Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-? through up-regulation of TNF receptor 1 in lung cancer cells.
Lung Neoplasms
Suppressed translation as a mechanism of initiation of CASP8 (caspase 8)-dependent apoptosis in autophagy-deficient NSCLC cells under nutrient limitation.
Lung Neoplasms
The ?-Carboline Alkaloid Harmol Induces Cell Death via Autophagy but Not Apoptosis in Human Non-small Cell Lung Cancer A549 Cells.
Lung Neoplasms
The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to ?v?5 integrin activation and TRAIL resistance in human lung cancer cells.
Lung Neoplasms
The impact of Caspase-8 on non-small cell lung cancer brain metastasis in II/III stage patient.
Lung Neoplasms
TIMP-3 promotes apoptosis in nonadherent small cell lung carcinoma cells lacking functional death receptor pathway.
Lung Neoplasms
Tumor suppressor in lung cancer-1 (TSLC1) mediated by dual-regulated oncolytic adenovirus exerts specific antitumor actions in a mouse model.
Lung Neoplasms
[Effect of supplement energy and nourish lung herbs on drug-resistance lung cancer with mechanisms of mitochondrial and caspase signal]
Lung Neoplasms
[Expression of caspase-8 in non-small cell lung cancer and its role in invasion and metastasis of lung cancer A549 cells].
Lung Neoplasms
[Expression of phosphorylated caspase-8 in non-small cell lung cancer and the clinical implications].
Lupus Erythematosus, Systemic
Anti-caspase-8 autoantibody response in silicosis patients is associated with HLA-DRB1, DQB1 and DPB1 alleles.
Lupus Erythematosus, Systemic
Increased serum IL-10 in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling.
Lymphadenopathy
Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner.
Lymphatic Metastasis
The impact of Caspase-8 on non-small cell lung cancer brain metastasis in II/III stage patient.
Lymphatic Metastasis
Understanding the Role of the Death Receptor 5/FADD/caspase-8 Death Signaling in Cancer Metastasis.
Lymphoma
A B-Cell Superantigen Induces the Apoptosis of Murine and Human Malignant B Cells.
Lymphoma
A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner.
Lymphoma
Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death.
Lymphoma
Anesthetic isoflurane posttreatment attenuates experimental lung injury by inhibiting inflammation and apoptosis.
Lymphoma
Anti-inflammatory and anti-apoptotic effects of oxysophoridine on lipopolysaccharide-induced acute lung injury in mice.
Lymphoma
Anticancer effect of resibufogenin on gastric carcinoma cells through the phosphoinositide 3-kinase/protein kinase B/glycogen synthase kinase 3? signaling pathway.
Lymphoma
Anticancer Effect of Ursodeoxycholic Acid in Human Oral Squamous Carcinoma HSC-3 Cells through the Caspases.
Lymphoma
Apoptosis and expression of caspases 3, 6 and 8 in malignant non-Hodgkin's lymphomas.
Lymphoma
B cell receptor signaling mediates immediate protection from Fas-induced apoptosis upstream of caspase activation through an atypical protein kinase C isozyme and de novo protein synthesis.
Lymphoma
C5, A Cassaine Diterpenoid Amine, Induces Apoptosis via the Extrinsic Pathways in Human Lung Cancer Cells and Human Lymphoma Cells.
Lymphoma
Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.
Lymphoma
Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis.
Lymphoma
Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation.
Lymphoma
Characterization of the human FLICE-inhibitory protein locus and comparison of the anti-apoptotic activity of four different flip isoforms.
Lymphoma
Complete Sperm Suppression in Rats With Dienogest Plus Testosterone Undecanoate Is Facilitated Through Apoptosis in Testicular Cells.
Lymphoma
Differential recruitment of caspase 8 to cFlip confers sensitivity or resistance to Fas-mediated apoptosis in a subset of familial lymphoma patients.
Lymphoma
Distinct role of CD80 and CD86 in the regulation of the activation of B cell and B cell lymphoma.
Lymphoma
Effects of EF-24, RAD001, and paclitaxel on the expression profiles of apoptotic and anti-apoptotic genes.
Lymphoma
FADD expression and caspase activation in B-cell lymphomas resistant to Fas-mediated apoptosis.
Lymphoma
Formyl peptide receptor-2 is decreased in foetal growth restriction and contributes to placental dysfunction.
Lymphoma
Frequent nuclear localization of ICAD and cytoplasmic co-expression of caspase-8 and caspase-3 in human lymphomas.
Lymphoma
Human allogeneic and murine xenogeneic dendritic cells are cytotoxic to human tumor cells via two distinct pathways.
Lymphoma
Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas.
Lymphoma
Impairment of death-inducing signalling complex formation in CD95-resistant human primary lymphoma B cells.
Lymphoma
Inhibition of p38 mitogen-activated protein kinase unmasks a CD30-triggered apoptotic pathway in anaplastic large cell lymphoma cells.
Lymphoma
Interferon-alpha induces transient upregulation of c-FLIP through NF-kappaB activation.
Lymphoma
Ionizing radiation and the activation of caspase-8 in highly apoptosis-sensitive lymphoma cells.
Lymphoma
Kaposi's sarcoma associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice.
Lymphoma
LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes.
Lymphoma
Motexafin gadolinium induces mitochondrially-mediated caspase-dependent apoptosis.
Lymphoma
Multiple Targets of 3-Dehydroxyceanothetric Acid 2-Methyl Ester to Protect Against Cisplatin-Induced Cytotoxicity in Kidney Epithelial LLC-PK1 Cells.
Lymphoma
Prokineticin 2 overexpression induces spermatocyte apoptosis in varicocele in rats.
Lymphoma
Resistance of Hematopoietic Progenitors to Fas-Mediated Apoptosis Is Actively Sustained by NF?B with a Characteristic Transcriptional Signature.
Lymphoma
Sialic acids linked to glycoconjugates of Fas regulate the caspase-9-dependent and mitochondria-mediated pathway of Fas-induced apoptosis in Jurkat T cell lymphoma.
Lymphoma
TGF beta 1 kills lymphoma cells using mitochondrial apoptotic pathway with the help of caspase-8.
Lymphoma
The Protective Role of Selenium Against AFB1-Induced Liver Apoptosis by Death Receptor Pathway in Broilers.
Lymphoma, B-Cell
9-cis retinoic acid inhibits cumulus cell apoptosis during the maturation of bovine cumulus-oocyte-complexes.
Lymphoma, B-Cell
All-trans retinoic acid improves goat oocyte nuclear maturation and reduces apoptotic cumulus cells during in vitro maturation.
Lymphoma, B-Cell
Altered apoptosis-related signaling after cardioplegic arrest in patients with uncontrolled type 2 diabetes mellitus.
Lymphoma, B-Cell
Ammonia inhalation impaired immune function and mitochondrial integrity in the broilers bursa of fabricius: Implication of oxidative stress and apoptosis.
Lymphoma, B-Cell
Antioxidative and hepatoprotective activities of the ethyl acetate fraction separated from the fruit of Livistona chinensis.
Lymphoma, B-Cell
Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NF?B signaling in HER2-overexpressing breast cancer cells.
Lymphoma, B-Cell
Calf Spleen Extractive Injection (CSEI), a small peptides enriched extraction, induces human hepatocellular carcinoma cell apoptosis via ROS/MAPKs dependent mitochondrial pathway.
Lymphoma, B-Cell
Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.
Lymphoma, B-Cell
Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation.
Lymphoma, B-Cell
Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9.
Lymphoma, B-Cell
Characterization of antiapoptotic microRNAs in primary Sjögren's syndrome.
Lymphoma, B-Cell
Coix lacryma-jobi var. ma-yuen Stapf sprout extract induces cell cycle arrest and apoptosis in human cervical carcinoma cells.
Lymphoma, B-Cell
Cordycepin, a Natural Antineoplastic Agent, Induces Apoptosis of Breast Cancer Cells via Caspase-dependent Pathways.
Lymphoma, B-Cell
Deficiency of dietary pyridoxine disturbed the intestinal physical barrier function of young grass carp (Ctenopharyngodon idella).
Lymphoma, B-Cell
Differential regulation of caspase-9 by ionizing radiation- and UV-induced apoptotic pathways in thymic cells.
Lymphoma, B-Cell
Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway.
Lymphoma, B-Cell
Effect of miR-155 knockdown on the reversal of doxorubicin resistance in human lung cancer A549/dox cells.
Lymphoma, B-Cell
Effects of dietary monocalcium phosphate supplementation on the anti-oxidative capacity, anti-bacteria function in immune organs of obscure puffer (Takifugu obscurus) after infection with Aeromonas hydrophila.
Lymphoma, B-Cell
Effects of prostaglandin F2? (PGF2?) on cell-death pathways in the bovine corpus luteum (CL).
Lymphoma, B-Cell
Expression of c-FLIP is primarily detected in diffuse large B-cell lymphoma and Hodgkin's lymphoma and correlates with lack of caspase 8 activation.
Lymphoma, B-Cell
Formyl peptide receptor-2 is decreased in foetal growth restriction and contributes to placental dysfunction.
Lymphoma, B-Cell
Galbanic acid potentiates TRAIL induced apoptosis in resistant non-small cell lung cancer cells via inhibition of MDR1 and activation of caspases and DR5.
Lymphoma, B-Cell
Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas.
Lymphoma, B-Cell
Implication of calpain in caspase activation during B cell clonal deletion.
Lymphoma, B-Cell
Inhibition of caspase 9 and not caspase 8 mediated apoptosis may determine clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas.
Lymphoma, B-Cell
Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells.
Lymphoma, B-Cell
Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling.
Lymphoma, B-Cell
Mechanism of anticancer action of novel berenil complex of platinum(II) combined with anti-MUC1 in MCF-7 breast cancer cells.
Lymphoma, B-Cell
MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival.
Lymphoma, B-Cell
Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest.
Lymphoma, B-Cell
Modulation of the DNA repair system and ATR-p53 mediated apoptosis is relevant for tributyltin-induced genotoxic effects in human hepatoma G2 cells.
Lymphoma, B-Cell
Multiple effects of Xihuang pill aqueous extract on the Hs578T triple-negative breast cancer cell line.
Lymphoma, B-Cell
Multiple Targets of 3-Dehydroxyceanothetric Acid 2-Methyl Ester to Protect Against Cisplatin-Induced Cytotoxicity in Kidney Epithelial LLC-PK1 Cells.
Lymphoma, B-Cell
Myristica fragrans Kernels Prevent Paracetamol-Induced Hepatotoxicity by Inducing Anti-Apoptotic Genes and Nrf2/HO-1 Pathway.
Lymphoma, B-Cell
Nuclear respiratory factor 1 protects H9C2 cells against hypoxia-induced apoptosis via the death receptor pathway and mitochondrial pathway.
Lymphoma, B-Cell
Palmitic Acid-Induced Podocyte Apoptosis via the Reactive Oxygen Species-Dependent Mitochondrial Pathway.
Lymphoma, B-Cell
Porin Expression Profiles in Haemaphysalis longicornis Infected With Babesia microti.
Lymphoma, B-Cell
Preparation of catechin extracts and nanoemulsions from green tea leaf waste and their inhibition effect on prostate cancer cell PC-3.
Lymphoma, B-Cell
Prognostic significance of O6-methylguanine DNA methyltransferase and p57 methylation in patients with diffuse large B-cell lymphomas.
Lymphoma, B-Cell
Prokineticin 2 overexpression induces spermatocyte apoptosis in varicocele in rats.
Lymphoma, B-Cell
Protective effect of hypoxylonol C and 4,5,4',5'-tetrahydroxy-1,1'-binaphthyl isolated from Annulohypoxylon annulatum against streptozotocin-induced damage in INS-1 cells.
Lymphoma, B-Cell
Quercetin enhances adriamycin cytotoxicity through induction of apoptosis and regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase/c-Jun N-terminal kinase signaling in multidrug-resistant leukemia K562 cells.
Lymphoma, B-Cell
Serum-free corneal organ culture medium (SFM) but not conventional minimal essential organ culture medium (MEM) protects human corneal endothelial cells from apoptotic and necrotic cell death.
Lymphoma, B-Cell
Sinoporphyrin Sodium-Mediated Sonodynamic Therapy Inhibits RIP3 Expression and Induces Apoptosis in the H446 Small Cell Lung Cancer Cell Line.
Lymphoma, B-Cell
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.
Lymphoma, B-Cell
Synergistic effect of celecoxib in tumor necrosis factor?related apoptosis?inducing ligand treatment in osteosarcoma cells.
Lymphoma, B-Cell
The Protective Role of Selenium Against AFB1-Induced Liver Apoptosis by Death Receptor Pathway in Broilers.
Lymphoma, B-Cell
The traditional Korean herbal medicine Ga-Gam-Nai-Go-Hyan suppresses testosterone-induced benign prostatic hyperplasia by regulating inflammatory responses and apoptosis.
Lymphoma, B-Cell
Thymoquinone from Nigella sativa Seeds Promotes the Antitumor Activity of Noncytotoxic Doses of Topotecan in Human Colorectal Cancer Cells in Vitro.
Lymphoma, B-Cell
TNF-?-TNFR signal pathway inhibits autophagy and promotes apoptosis of alveolar macrophages in coal worker's pneumoconiosis.
Lymphoma, B-Cell
Toll like receptor 4 signaling pathway participated in Salmonella lipopolysaccharide-induced spleen injury in young chicks.
Lymphoma, B-Cell
Trace Mineral Overload Induced Hepatic Oxidative Damage and Apoptosis in Pigs with Long-Term High-Level Dietary Mineral Exposure.
Lymphoma, B-Cell
Ulinastatin improves myocardial ischemia-reperfusion injury in rats through endoplasmic reticulum stress-induced apoptosis pathway.
Lymphoma, B-Cell
YopJ-induced caspase-1 activation in Yersinia-infected macrophages: independent of apoptosis, linked to necrosis, dispensable for innate host defense.
Lymphoma, B-Cell
[Celastrol inhibits growth and increases apoptosis of human lung cancer A549 cells].
Lymphoma, B-Cell, Marginal Zone
Inhibition of caspase-8 activity caused by overexpression of bcl10 contributes to the pathogenesis of high-grade MALT lymphoma.
Lymphoma, B-Cell, Marginal Zone
Resistance of Hematopoietic Progenitors to Fas-Mediated Apoptosis Is Actively Sustained by NF?B with a Characteristic Transcriptional Signature.
Lymphoma, Follicular
The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP.
Lymphoma, Large B-Cell, Diffuse
Expression of c-FLIP is primarily detected in diffuse large B-cell lymphoma and Hodgkin's lymphoma and correlates with lack of caspase 8 activation.
Lymphoma, Large B-Cell, Diffuse
Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas.
Lymphoma, Large-Cell, Anaplastic
Inhibition of p38 mitogen-activated protein kinase unmasks a CD30-triggered apoptotic pathway in anaplastic large cell lymphoma cells.
Lymphoma, Non-Hodgkin
Frequent nuclear localization of ICAD and cytoplasmic co-expression of caspase-8 and caspase-3 in human lymphomas.
Lymphoma, Non-Hodgkin
Genetic polymorphisms of the CASP8 gene promoter may not be associated with colorectal cancer in Han Chinese from southwest China.
Lymphoma, Non-Hodgkin
Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma.
Lymphoma, Non-Hodgkin
Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin's lymphoma in Chinese patients.
Lymphoma, Primary Effusion
A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner.
Lymphoma, T-Cell
Sialic acids linked to glycoconjugates of Fas regulate the caspase-9-dependent and mitochondria-mediated pathway of Fas-induced apoptosis in Jurkat T cell lymphoma.
Lymphoma, T-Cell
Vps41, a protein involved in lysosomal trafficking, interacts with caspase-8.
Lymphoproliferative Disorders
Constitutive NF-kappaB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice.
Malocclusion
TNF Accelerates Death of Mandibular Condyle Chondrocytes in Rats with Biomechanical Stimulation-Induced Temporomandibular Joint Disease.
Massive Hepatic Necrosis
Intrahepatic activation of caspases in human fulminant hepatic failure.
Medulloblastoma
5-Aza-2'-deoxycytidine and IFN-gamma cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8.
Medulloblastoma
Deletion and aberrant CpG island methylation of Caspase 8 gene in medulloblastoma.
Medulloblastoma
Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.
Medulloblastoma
Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling.
Medulloblastoma
Interferon-gamma mediated up-regulation of caspase-8 sensitizes medulloblastoma cells to radio- and chemotherapy.
Medulloblastoma
Loss of caspase-8 protein expression correlates with unfavorable survival outcome in childhood medulloblastoma.
Medulloblastoma
Promoter methylation pattern of caspase-8, P16INK4A, MGMT, TIMP-3, and E-cadherin in medulloblastoma.
Medulloblastoma
Retinoic acid induces caspase-8 transcription via phospho-CREB and increases apoptotic responses to death stimuli in neuroblastoma cells.
Medulloblastoma
The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma.
Melanoma
Activation-induced cell death of human melanoma specific cytotoxic T lymphocytes is mediated by apoptosis-inducing factor.
Melanoma
Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell death.
Melanoma
Antitumoral synergism between a copper(II) complex and cisplatin improves in vitro and in vivo anticancer activity against melanoma, lung and breast cancer cells.
Melanoma
Autocrine secretion of 15d-PGJ2 mediates simvastatin-induced apoptotic burst in human metastatic melanoma cells.
Melanoma
Casp8 acts through A20 to inhibit PD-L1 expression: The mechanism and its implication in immunotherapy.
Melanoma
Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN.
Melanoma
Cationic folate-mediated liposomal delivery of bis-arylidene oxindole induces efficient melanoma tumor regression.
Melanoma
Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIP(L) from degradation by the E3 ligase itch in human melanoma cells.
Melanoma
Downregulation of Bcl-2 and activation of caspase-8 in the UVB-induced apoptosis of a cultured human melanoma cell line.
Melanoma
Enhanced anti-melanoma efficacy of interferon ?-2b via overexpression of ING4 by enhanced Fas/FasL-mediated apoptosis.
Melanoma
Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma.
Melanoma
Identification of a novel gelsolin truncate in the vertical and metastatic phase malignant melanomas.
Melanoma
IFN-beta pretreatment sensitizes human melanoma cells to TRAIL/Apo2 ligand-induced apoptosis.
Melanoma
Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein.
Melanoma
Induction of indoleamine 2, 3-dioxygenase by death receptor activation contributes to apoptosis of melanoma cells via mitochondrial damage-dependent ROS accumulation.
Melanoma
Inhibition of CaMKII-mediated c-FLIP expression sensitizes malignant melanoma cells to TRAIL-induced apoptosis.
Melanoma
Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein.
Melanoma
Initiation of apoptosis by photodynamic therapy using a novel positively charged and water-soluble near infra-red photosensitizer and white light irradiation.
Melanoma
Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors.
Melanoma
Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib.
Melanoma
P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma.
Melanoma
Plumbagin enhances TRAIL-mediated apoptosis through up-regulation of death receptor in human melanoma A375 cells.
Melanoma
Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells.
Melanoma
Pyrimethamine induces apoptosis of melanoma cells via a caspase and cathepsin double-edged mechanism.
Melanoma
Regulation of apoptosis in human melanoma and neuroblastoma cells by statins, sodium arsenite and TRAIL: a role of combined treatment versus monotherapy.
Melanoma
Resistance of melanoma cells to TRAIL does not result from upregulation of antiapoptotic proteins by NF-kappaB but is related to downregulation of initiator caspases and DR4.
Melanoma
Rusticyanin, a bacterial electron transfer protein, causes G1 arrest in J774 and apoptosis in human cancer cells.
Melanoma
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer.
Melanoma
siRNA - Mediated LRP/LR knock-down reduces cellular viability of malignant melanoma cells through the activation of apoptotic caspases.
Melanoma
Targeting TGF-?-Mediated SMAD Signaling Pathway via Novel Recombinant Cytotoxin II: A Potent Protein from Naja naja oxiana Venom in Melanoma.
Melanoma
The histone deacetylase inhibitor suberic bishydroxamate: a potential sensitizer of melanoma to TNF-related apoptosis-inducing ligand (TRAIL) induced apoptosis.
Melanoma
Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors.
Melanoma
TNF-related apoptosis-inducing ligand-induced apoptosis of melanoma is associated with changes in mitochondrial membrane potential and perinuclear clustering of mitochondria.
Meningioma
CASP8, XRCC1, WRN, NF2 and BRIP1 polymorphisms analysis reveals their genetic susceptibility for meningioma risk and the association with tumor-related phenotype in Chinese population.
Meningioma
Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults.
Mesothelioma
Resistance to caspase-8 and -9 fragments in a malignant pleural mesothelioma cell line with acquired cisplatin-resistance.
Mesothelioma
Taurolidine and oxidative stress: a rationale for local treatment of mesothelioma.
Mesothelioma, Malignant
1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol as a potential anticancer drug.
Mesothelioma, Malignant
Resistance to caspase-8 and -9 fragments in a malignant pleural mesothelioma cell line with acquired cisplatin-resistance.
Molluscum Contagiosum
Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function.
Molluscum Contagiosum
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.
Molluscum Contagiosum
Functional Comparison of Molluscum Contagiosum Virus vFLIP MC159 with Murine Cytomegalovirus M36/vICA and M45/vIRA Proteins.
Molluscum Contagiosum
Herpesvirus saimiri vFLIP provides an antiapoptotic function but is not essential for viral replication, transformation, or pathogenicity.
Molluscum Contagiosum
The death effector domains (DEDs) of the molluscum contagiosum virus MC159 v-FLIP protein are not functionally interchangeable with each other or with the DEDs of caspase-8.
Mouth Neoplasms
Absence of the frequently reported PIK3CA, CASP8, and NOTCH1 mutations in South Indian oral cancers.
Mouth Neoplasms
Apoptotic effects of dehydrocrenatidine via JNK and ERK pathway regulation in oral squamous cell carcinoma.
Mouth Neoplasms
Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic-induced necroptosis.
Mouth Neoplasms
Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model.
Mouth Neoplasms
In silico analysis reveals a shared immune signature in CASP8-mutated carcinomas with varying correlations to prognosis.
Mouth Neoplasms
Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway.
Mouth Neoplasms
Soy protein extract (SPE) exhibits differential in vitro cell proliferation effects in oral cancer and normal cell lines.
Mouth Neoplasms
Study of Caspase 8 mutation in oral cancer and adjacent precancer tissues and implication in progression.
Mouth Neoplasms
Tetrandrine induces apoptosis Via caspase-8, -9, and -3 and poly (ADP ribose) polymerase dependent pathways and autophagy through beclin-1/ LC3-I, II signaling pathways in human oral cancer HSC-3 cells.
Mouth Neoplasms
The Proteomic Landscape of Growth Factor Signaling Networks Associated with FAT1 Mutations in Head and Neck Cancers.
Multiple Endocrine Neoplasia
Menin-mediated Caspase 8 Expression in Suppressing Multiple Endocrine Neoplasia Type 1.
Multiple Endocrine Neoplasia Type 1
Menin-mediated Caspase 8 Expression in Suppressing Multiple Endocrine Neoplasia Type 1.
Multiple Myeloma
1'-Acetoxychavicol acetate induces apoptosis of myeloma cells via induction of TRAIL.
Multiple Myeloma
Imexon-induced apoptosis in multiple myeloma tumor cells is caspase-8 dependent.
Multiple Myeloma
Myxoma Virus Induces Ligand Independent Extrinsic Apoptosis in Human Myeloma Cells.
Multiple Myeloma
[Effects of docetaxel on proliferation and apoptosis of human multiple myeloma cell RPMI8226].
Multiple Sclerosis
Decreased levels of CD95 and caspase-8 mRNA in multiple sclerosis patients with gadolinium-enhancing lesions on MRI.
Multiple Sclerosis
Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein.
Multiple Sclerosis
Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis.
Multiple Sclerosis
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation.
Multiple Sclerosis, Chronic Progressive
Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis.
Muscle Spasticity
Caspase inhibitors prevent endothelial apoptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhage.
Muscular Dystrophies
Tumour necrosis factor-mediated cell death pathways do not contribute to muscle fibre death in dystrophinopathies.
Myocardial Infarction
[Change of JNK MAPK and its influence on cardiocyte apoptosis in ischemic postconditioning]
Myocardial Ischemia
[The effects of salidroside on the apoptosis pathway of myocardial cells in acute exhausted rats].
Myocarditis
Reduced myocarditis following Coxsackievirus infection in cellular FLICE inhibitory protein--long form-transgenic mice.
Myoclonic Epilepsies, Progressive
Structure based molecular inhibition of Caspase-8 for treatment of multi-neurodegenerative diseases using known natural compounds.
Nasal Polyps
Increased phosphorylation of eNOS in nasal polyps of chronic rhinosinusitis patients can be diminished by 1,8-cineol.
Nasopharyngeal Carcinoma
Association of Caspase-8 Genotypes With the Risk for Nasopharyngeal Carcinoma in Taiwan.
Nasopharyngeal Carcinoma
Junduqing extractive promotes the apoptosis of nasopharyngeal carcinoma cells through down-regulating Mcl-1 and Bcl-xL and up-regulating Caspase-3, Caspase-8 and Caspase-9.
Nasopharyngeal Carcinoma
[Reduced expression of CASP8 in nasopharyngeal carcinoma and its clinical significance].
Nasopharyngeal Carcinoma
[The inhibited effect of matrine on human nasopharyngeal carcinoma CNE2 cells and the expression of apoptosis related gene Caspase in vitro].
Neoplasm Metastasis
A gene expression signature predicts survival of patients with stage I non-small cell lung cancer.
Neoplasm Metastasis
Alterations of Fas-pathway genes associated with nodal metastasis in non-small cell lung cancer.
Neoplasm Metastasis
Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact.
Neoplasm Metastasis
Anti-tumor activities of luteolin and silibinin in glioblastoma cells: overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo.
Neoplasm Metastasis
c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.
Neoplasm Metastasis
c-Src Increases the Sensitivity to TKIs in the EGFR-Mutant Lung Adenocarcinoma.
Neoplasm Metastasis
Carcinoembryonic antigen inhibits anoikis in colorectal carcinoma cells by interfering with TRAIL-R2 (DR5) signaling.
Neoplasm Metastasis
Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis.
Neoplasm Metastasis
Caspase-8: A key protein of cross-talk signal way in "PANoptosis" in cancer.
Neoplasm Metastasis
Contribution of Caspase-8 Genotypes to Colorectal Cancer Risk in Taiwan.
Neoplasm Metastasis
EMT phenotype is induced by increased Src kinase activity via Src-mediated caspase-8 phosphorylation.
Neoplasm Metastasis
Expression of 6 Common Antigenic Markers in Invasive Ductal Breast Carcinoma: Potential Clinical Implications.
Neoplasm Metastasis
Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma.
Neoplasm Metastasis
FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastoma.
Neoplasm Metastasis
Fructooligosaccharides and wheat bran fed at similar fermentation levels differentially affect the expression of genes involved in transport, signaling, apoptosis, cell proliferation, and oncogenesis in the colon epithelia of healthy Fischer 344 rats.
Neoplasm Metastasis
Halting Neuroblastoma Metastasis by Controlling Integrin-Mediated Death.
Neoplasm Metastasis
Intratumoural heterogeneity and clone evolution of oral squamous cell carcinoma.
Neoplasm Metastasis
Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy.
Neoplasm Metastasis
Protein expression differences between lung adenocarcinoma and squamous cell carcinoma with brain metastasis.
Neoplasm Metastasis
SLPI promotes the gastric cancer growth and metastasis by regulating the expression of P53, Bcl-2 and Caspase-8.
Neoplasm Metastasis
Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling.
Neoplasm Metastasis
Targeting caspase 8 to reduce the formation of metastases in neuroblastoma.
Neoplasm Metastasis
Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.
Neoplasm Metastasis
The CASP8 -652 6N insertion/deletion promoter polymorphism is associated with renal cell carcinoma risk and metastasis.
Neoplasm Metastasis
The impact of Caspase-8 on non-small cell lung cancer brain metastasis in II/III stage patient.
Neoplasm Metastasis
Understanding the Role of the Death Receptor 5/FADD/caspase-8 Death Signaling in Cancer Metastasis.
Neoplasm Metastasis
[Expression of caspase-8 in non-small cell lung cancer and its role in invasion and metastasis of lung cancer A549 cells].
Neoplasms
1,2-Dichloroethane induces cerebellum granular cell apoptosis via mitochondrial pathway in vitro and in vivo.
Neoplasms
16-Hydroxycleroda-3,13-dien-15,16-olide and N-Methyl-Actinodaphine Potentiate Tamoxifen-Induced Cell Death in Breast Cancer.
Neoplasms
18?-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines.
Neoplasms
3-m-bromoacetylamino benzoic acid ethyl ester: a new cancericidal agent that activates the apoptotic pathway through caspase-9.
Neoplasms
4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells.
Neoplasms
5-Aza-2'-deoxycytidine and IFN-gamma cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8.
Neoplasms
5-epi-Sinuleptolide induces cell cycle arrest and apoptosis through tumor necrosis factor/mitochondria-mediated caspase signaling pathway in human skin cancer cells.
Neoplasms
5-Fluorouracil signaling through a calcium-calmodulin-dependent pathway is required for p53 activation and apoptosis in colon carcinoma cells.
Neoplasms
9-cis retinoic acid inhibits cumulus cell apoptosis during the maturation of bovine cumulus-oocyte-complexes.
Neoplasms
?-Catenin-dependent lysosomal targeting of internalized tumor necrosis factor-? suppresses caspase-8 activation in apoptosis-resistant colon cancer cells.
Neoplasms
?-Hydroxybutyrate exacerbates lipopolysaccharide/ d-galactosamine-induced inflammatory response and hepatocyte apoptosis in mice.
Neoplasms
A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma.
Neoplasms
A combination hybrid-based vaccination/adoptive cellular therapy to prevent tumor growth by involvement of T cells.
Neoplasms
A gene expression signature predicts survival of patients with stage I non-small cell lung cancer.
Neoplasms
A high-content AlphaScreen identifies E6-specific small molecule inhibitors as potential therapeutics for HPV+ head and neck squamous cell carcinomas.
Neoplasms
A meta-analysis of caspase-8 -652 6N del polymorphism and digestive tract cancer risk.
Neoplasms
A Morphological and Molecular Characterization of the Spinal Cord after Ventral Root Avulsion or Distal Peripheral Nerve Axotomy Injuries in Adult Rats.
Neoplasms
A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis.
Neoplasms
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death.
Neoplasms
A novel single amino acid deletion caspase-8 mutant in cancer cells that lost proapoptotic activity.
Neoplasms
A novel telomerase-specific gene therapy: gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter.
Neoplasms
A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis.
Neoplasms
A polysaccharide from Trametes robiniophila inhibits human osteosarcoma xenograft tumor growth in vivo.
Neoplasms
A protective effect after clearance of orthotopic rat hepatocellular carcinoma by nanosecond pulsed electric fields.
Neoplasms
A six-nucleotide deletion polymorphism in the casp8 promoter is associated with reduced risk of esophageal and gastric cancers in Kashmir valley.
Neoplasms
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter associated with risk and progression of bladder cancer.
Neoplasms
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers.
Neoplasms
A systematic analysis of the association studies between CASP8 D302H polymorphisms and breast cancer risk.
Neoplasms
Aberrant DNA methylation of apoptotic signaling genes in patients responsive and nonresponsive to therapy for cervical carcinoma.
Neoplasms
Aberrant promoter methylation of multiple genes throughout the clinico-pathologic spectrum of B-cell neoplasia.
Neoplasms
Absence of the frequently reported PIK3CA, CASP8, and NOTCH1 mutations in South Indian oral cancers.
Neoplasms
Abundance of TRAIL attenuated by HIF2? and c-FLIP affects malignancy in renal cell carcinomas.
Neoplasms
Activation of caspase-8 by tumour necrosis factor receptor 1 is necessary for caspase-3 activation and apoptosis in oxygen-glucose deprived cultured cortical cells.
Neoplasms
Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice.
Neoplasms
Activation of the c-Jun N-terminal kinase/stress-activated protein kinase pathway by overexpression of caspase-8 and its homologs.
Neoplasms
Adenoviral-mediated transfer of the TNF-related apoptosis-inducing ligand/Apo-2 ligand gene induces tumor cell apoptosis.
Neoplasms
Adenovirus-mediated gene transfer of caspase-8 sensitizes human adenocarcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand.
Neoplasms
Adenovirus-mediated transfection of caspase-8 augments anoikis and inhibits peritoneal dissemination of human gastric carcinoma cells.
Neoplasms
Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic cancer cell lines.
Neoplasms
Advances in revealing the molecular targets downstream of oxidative stress-induced proapoptotic kinase signaling in diabetic embryopathy.
Neoplasms
Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell death.
Neoplasms
Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells.
Neoplasms
Alamandine protects against renal ischaemia-reperfusion injury in rats via inhibiting oxidative stress.
Neoplasms
All HPV-negative head and neck cancers are not the same: Analysis of the TCGA dataset reveals that anatomical sites have distinct mutation, transcriptome, hypoxia, and tumor microenvironment profiles.
Neoplasms
Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma.
Neoplasms
Aloe-emodin (AE) nanoparticles suppresses proliferation and induces apoptosis in human lung squamous carcinoma via ROS generation in vitro and in vivo.
Neoplasms
alpha-fetoprotein causes apoptosis in tumor cells via a pathway independent of CD95, TNFR1 and TNFR2 through activation of caspase-3-like proteases.
Neoplasms
Alterations of Fas-pathway genes associated with nodal metastasis in non-small cell lung cancer.
Neoplasms
Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
Neoplasms
Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation.
Neoplasms
Ampelopsin Induces DR5-Mediated Apoptotic Cell Death in EBV-Infected Cells through the p38 Pathway.
Neoplasms
An Antisense Oligonucleotide Drug Targeting miR-21 Induces H1650 Apoptosis and Caspase Activation.
Neoplasms
An apoptosis signaling pathway induced by the death domain of FADD selectively kills normal but not cancerous prostate epithelial cells.
Neoplasms
An apoptotic molecular network identified by microarray: on the TRAIL to new insights in epithelial ovarian cancer.
Neoplasms
An exploratory analysis of the effects of a weight loss plus exercise program on cellular quality control mechanisms in older overweight women.
Neoplasms
Analysis of a mitochondrial apoptotic pathway using Bid-targeted ribozymes in human MCF7 cells in the absence of a caspase-3-dependent pathway.
Neoplasms
Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact.
Neoplasms
Analysis of Serum Markers with Regard to Treatment Procedures in Advanced Stage Prostate Cancer Patients.
Neoplasms
Analysis of the Effect of Gentian Violet on Apoptosis and Proliferation in Cutaneous T-Cell Lymphoma in an In Vitro Study.
Neoplasms
Anti-apoptotic and pro-survival effect of exercise training on early aged hypertensive rat cerebral cortex.
Neoplasms
Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts.
Neoplasms
Anti-cancer effect of tectochrysin in NSCLC cells through overexpression of death receptor and inactivation of STAT3.
Neoplasms
Anti-EMMPRIN antibody treatment of head and neck squamous cell carcinoma in an ex-vivo model.
Neoplasms
Anti-tumor effect by inhibition of NF-kappaB activation using nafamostat mesilate for pancreatic cancer in a mouse model.
Neoplasms
Antiapoptotic and mitochondrial biogenetic effects of exercise training on ovariectomized hypertensive rat hearts.
Neoplasms
Antiapoptotic Small Interfering RNA as Potent Adjuvant of DNA Vaccination in a Mouse Mammary Tumor Model.
Neoplasms
Anticancer activity of a cyclooxygenase inhibitor, CX9051, in human prostate cancer cells: the roles of NF-kappaB and crosstalk between the extrinsic and intrinsic apoptotic pathways.
Neoplasms
Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis.
Neoplasms
Anticancer targets and mechanisms of calycosin to treat nasopharyngeal carcinoma.
Neoplasms
Antioxidants impair anti-tumoral effects of vorinostat, but not anti-neoplastic effects of vorinostat and caspase-8 downregulation.
Neoplasms
Antitumor activity of decoy oligodeoxynucleotides targeted to NF-kappaB in vitro and in vivo.
Neoplasms
Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment.
Neoplasms
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.
Neoplasms
Apoptosis inducing effects of Kuding tea polyphenols in human buccal squamous cell carcinoma cell line BcaCD885.
Neoplasms
Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis.
Neoplasms
Apoptosis-inducing factor (AIF) is targeted in IFN-?2a-induced Bid-mediated apoptosis through Bak activation in ovarian cancer cells.
Neoplasms
Apoptosis-related gene expression can predict the response of ovarian cancer cell lines to treatment with recombinant human TRAIL alone or combined with cisplatin.
Neoplasms
Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.
Neoplasms
Apoptotic effects of protocatechuic acid in human breast, lung, liver, cervix, and prostate cancer cells: potential mechanisms of action.
Neoplasms
Apoptotic markers and DNA damage are related to late phase of stroke: Involvement of dyslipidemia and inflammation.
Neoplasms
Aprotinin improves kidney function and decreases tubular cell apoptosis and proapoptotic signaling after renal ischemia-reperfusion.
Neoplasms
ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.
Neoplasms
Arsenic Trioxide Induces Apoptosis of Fibroblast-like Synoviocytes and Represents Antiarthritis Effect in Experimental Model of Rheumatoid Arthritis.
Neoplasms
Artonin E sensitizes TRAIL-induced apoptosis by DR5 upregulation and cFLIP downregulation in TRAIL-refractory colorectal cancer LoVo cells.
Neoplasms
Association between CASP8 -652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study.
Neoplasms
Association Between CASP8 and CASP10 Polymorphisms and Toxicity Outcomes with Platinum-Based Chemotherapy in Chinese Patients with Non-Small Cell Lung Cancer.
Neoplasms
Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death.
Neoplasms
Association of CASP3 polymorphism with hematologic toxicity in patients with advanced non-small-cell lung carcinoma treated with platinum-based chemotherapy.
Neoplasms
Association of caspase 8 polymorphisms -652 6N InsDel and Asp302His with progression-free survival and tumor infiltrating lymphocytes in early breast cancer.
Neoplasms
Association of Caspase-8 Genotypes With the Risk for Nasopharyngeal Carcinoma in Taiwan.
Neoplasms
Association of epigenetic inactivation of RASSF1A with poor outcome in human neuroblastoma.
Neoplasms
Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and Brachytherapy.
Neoplasms
Attenuating ischemia/reperfusion injury in rat cardiac transplantation by intracoronary infusion with siRNA cocktail solution.
Neoplasms
Attenuation of Aluminum Chloride-Induced Neuroinflammation and Caspase Activation Through the AKT/GSK-3? Pathway by Hesperidin in Wistar Rats.
Neoplasms
Autophagy-competent mitochondrial translation elongation factor TUFM inhibits caspase-8-mediated apoptosis.
Neoplasms
Azidothymidine is Effective against Human Multiple Myeloma: A New Use for an Old Drug?
Neoplasms
Bax, cytochrome c, and caspase-8 staining in parotid cancer patients: markers of susceptibility in radiotherapy?
Neoplasms
Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells.
Neoplasms
Bcl-xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells.
Neoplasms
Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli.
Neoplasms
Benzo(a)pyrene-coated onto Fe2O3 particles-induced apoptotic events in the lungs of Sprague-Dawley rats.
Neoplasms
Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways.
Neoplasms
Berberine induced apoptosis via promoting the expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G in SCC-4 human tongue squamous carcinoma cancer cells.
Neoplasms
Betulinic acid exerts immunoregulation and anti-tumor effect on cervical carcinoma (U14) tumor-bearing mice.
Neoplasms
Bi-directional PCR allele-specific amplification (bi-PASA) for detection of caspase-8 -652 6N ins/del promoter polymorphism (rs3834129) in breast cancer.
Neoplasms
BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane.
Neoplasms
Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF-?B Activation, and Is Active in Patient-Derived Xenograft Models.
Neoplasms
Bisphenol A diglycidyl ether-induced apoptosis involves Bax/Bid-dependent mitochondrial release of apoptosis-inducing factor (AIF), cytochrome c and Smac/DIABLO.
Neoplasms
Blockade of paclitaxel-induced thymidine phosphorylase expression can accelerate apoptosis in human prostate cancer cells.
Neoplasms
Bortezomib abolishes tumor necrosis factor-related apoptosis-inducing ligand resistance via a p21-dependent mechanism in human bladder and prostate cancer cells.
Neoplasms
Bortezomib treatment and regulatory T-cell depletion enhance the anti-tumor effects of adoptively infused NK cells.
Neoplasms
Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses.
Neoplasms
Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways.
Neoplasms
Bulnesia sarmientoi Supercritical Fluid Extract Exhibits Necroptotic Effects and Anti-Metastatic Activity on Lung Cancer Cells.
Neoplasms
C-27-carboxylated oleanane triterpenoids up-regulate TRAIL DISC assembly via p38 MAPK and CHOP-mediated DR5 expression in human glioblastoma cells.
Neoplasms
C1q/tumor necrosis factor-related protein-6 attenuates TNF-?-induced apoptosis in salivary acinar cells via AMPK/SIRT1-modulated miR-34a-5p expression.
Neoplasms
C5, A Cassaine Diterpenoid Amine, Induces Apoptosis via the Extrinsic Pathways in Human Lung Cancer Cells and Human Lymphoma Cells.
Neoplasms
Cadmium exposure induces apoptosis, inflammation and immunosuppression through CYPs activation and antioxidant dysfunction in common carp neutrophils.
Neoplasms
Cadmium inhibits both intrinsic and extrinsic apoptotic pathways in renal mesangial cells.
Neoplasms
Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors.
Neoplasms
Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28.
Neoplasms
Cancer-associated fibroblasts induce cancer cell apoptosis that regulates invasion mode of tumours.
Neoplasms
Cancer-associated missense mutations of caspase-8 activate nuclear factor-?B signaling.
Neoplasms
Carcinoembryonic antigen inhibits anoikis in colorectal carcinoma cells by interfering with TRAIL-R2 (DR5) signaling.
Neoplasms
Cardiomyocyte death in patients with end-stage heart failure before and after support with a left ventricular assist device: low incidence of apoptosis despite ubiquitous mediators.
Neoplasms
CASP-8 -652 6N ins/del polymorphism and cancer risk: A literature-based systematic HuGE review and meta-analysis.
Neoplasms
CASP8 (rs3834129) and CASP3 (rs4647601) polymorphisms in oropharynx cancer risk, tumor cell differentiation, and prognosis in a cohort of the Brazilian population.
Neoplasms
CASP8 -652 6N del and CASP8 IVS12-19G>A gene polymorphisms and susceptibility/prognosis of ESCC: A case control study in northern Indian population.
Neoplasms
CASP8 -652 6N del polymorphism and cancer risk: a meta-analysis of 30 case-control studies in 50 112 subjects.
Neoplasms
CASP8 -652 6N del polymorphism contributes to colorectal cancer susceptibility: evidence from a meta-analysis.
Neoplasms
CASP8 -652 6N insertion/deletion polymorphism and overall cancer risk: evidence from 49 studies.
Neoplasms
Casp8 acts through A20 to inhibit PD-L1 expression: The mechanism and its implication in immunotherapy.
Neoplasms
CASP8 polymorphisms contribute to cancer susceptibility: evidence from a meta-analysis of 23 publications with 55 individual studies.
Neoplasms
CASP8 promoter polymorphism is associated with high-risk HPV types and abnormal cytology but not with cervical cancer.
Neoplasms
CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population.
Neoplasms
Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation.
Neoplasms
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN.
Neoplasms
Caspase 8-dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus-infection.
Neoplasms
Caspase 8L, a novel inhibitory isoform of caspase 8, is associated with undifferentiated neuroblastoma.
Neoplasms
Caspase-3, caspase-8, and nuclear factor-kappaB expression in human cholesteatoma.
Neoplasms
Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP.
Neoplasms
Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis.
Neoplasms
Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma.
Neoplasms
Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells.
Neoplasms
Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma.
Neoplasms
Caspase-8 dependent TRAIL-induced apoptosis in cancer cell lines is inhibited by vitamin C and catalase.
Neoplasms
Caspase-8 expression and its Src-dependent phosphorylation on Tyr380 promote cancer cell neoplastic transformation and resistance to anoikis.
Neoplasms
Caspase-8 expression is predictive of tumour response to death receptor 5 agonist antibody in Ewing's sarcoma.
Neoplasms
Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis.
Neoplasms
Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis.
Neoplasms
Caspase-8 is scarcely silenced and its activity is well correlated with the anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand in gastric cancer cells.
Neoplasms
Caspase-8 levels correlate with the expression of signal transducer and activator of transcription 1 in high-grade but not lower grade neuroblastoma.
Neoplasms
Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic-induced necroptosis.
Neoplasms
Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction.
Neoplasms
Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth.
Neoplasms
Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against Toxoplasma gondii.
Neoplasms
Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions.
Neoplasms
Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex.
Neoplasms
Caspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappaB through c-FLIP-L expression.
Neoplasms
Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma.
Neoplasms
Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN.
Neoplasms
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
Neoplasms
Catalytically active Yersinia outer protein P induces cleavage of RIP and caspase-8 at the level of the DISC independently of death receptors in dendritic cells.
Neoplasms
Cationic folate-mediated liposomal delivery of bis-arylidene oxindole induces efficient melanoma tumor regression.
Neoplasms
CCL16/LEC powerfully triggers effector and antigen-presenting functions of macrophages and enhances T cell cytotoxicity.
Neoplasms
CCL2 and IL-6 promote survival of human CD11b+- peripheral blood mononuclear cells and induce M2-type macrophage polarization.
Neoplasms
CD95 apoptosis resistance in certain cells can be overcome by noncanonical activation of caspase-8.
Neoplasms
Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9.
Neoplasms
Cell death of MCF-7 human breast cancer cells induced by EGFR activation in the absence of other growth factors.
Neoplasms
Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells.
Neoplasms
Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.
Neoplasms
Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes.
Neoplasms
Cerebellar Upregulation of Cell Surface Death Receptor-Mediated Apoptotic Factors in Harmaline-Induced Tremor: An Immunohistochemistry Study.
Neoplasms
CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl-positive human leukemia cells to apoptosis due to antileukemic drugs.
Neoplasms
Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.
Neoplasms
Characterization of a p75(NTR) apoptotic signaling pathway using a novel cellular model.
Neoplasms
Chelerythrin activates caspase-8, downregulates FLIP long and short, and overcomes resistance to tumour necrosis factor-related apoptosis-inducing ligand in KG1a cells.
Neoplasms
Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis.
Neoplasms
Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential.
Neoplasms
Chemotherapy with hybrid liposomes for human breast tumors along with apoptosis in vivo.
Neoplasms
Chemotherapy-induced apoptosis of S-type neuroblastoma cells requires caspase-9 and is augmented by CD95/Fas stimulation.
Neoplasms
Chlamydia trachomatis fails to protect its growth niche against pro-apoptotic insults.
Neoplasms
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis.
Neoplasms
Cleavage of caspases-1, -3, -6, -8 and -9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexia.
Neoplasms
Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer.
Neoplasms
Clinicopathological significance of caspase-8 and caspase-10 expression in rectal cancer.
Neoplasms
Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: implication for cancer specific therapy.
Neoplasms
Combination of Ad-sTRAIL with the chemotherapeutic drug cisplatin synergistically enhances their pro-apoptotic ability in human breast cancer cells.
Neoplasms
Combination of oncolytic adenovirus targeting SATB1 and docetaxel for the treatment of castration-resistant prostate cancer.
Neoplasms
Combination of quercetin and cisplatin enhances apoptosis in OSCC cells by downregulating xIAP through the NF-?B pathway.
Neoplasms
Combination of TNF-? and graphene oxide-loaded BEZ235 to enhance apoptosis of PIK3CA mutant colorectal cancer cells.
Neoplasms
Combination of Vorinostat and caspase-8 inhibition exhibits high anti-tumoral activity on endometrial cancer cells.
Neoplasms
Combined analysis and validation for DNA methylation and gene expression profiles associated with prostate cancer.
Neoplasms
Combined effects of 17?-estradiol and exercise training on cardiac apoptosis in ovariectomized rats.
Neoplasms
Comparing different physical factors on serum TNF-? levels, chondrocyte apoptosis, caspase-3 and caspase-8 expression in osteoarthritis of the knee in rabbits.
Neoplasms
Compound 21 and Telmisartan combination mitigates type 2 diabetic nephropathy through amelioration of caspase mediated apoptosis.
Neoplasms
Comprehensive analysis of DNA methylation in head and neck squamous cell carcinoma indicates differences by survival and clinicopathologic characteristics.
Neoplasms
Comprehensive genomic characterization of head and neck squamous cell carcinomas.
Neoplasms
Conditionally replicating adenovirus combined with gene-targeted radiotherapy induces apoptosis via TRAIL death receptors in MDA-MB-231 cells.
Neoplasms
Confirmation by FRET in individual living cells of the absence of significant amyloid beta -mediated caspase 8 activation.
Neoplasms
Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death.
Neoplasms
Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3.
Neoplasms
Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo.
Neoplasms
Control of FLIP(L) expression and TRAIL resistance by the extracellular signal-regulated kinase1/2 pathway in breast epithelial cells.
Neoplasms
CORDYCEPS SINENSIS MYCELIUM INDUCES MA-10 MOUSE LEYDIG TUMOR CELL APOPTOSIS BY ACTIVATING THE CASPASE-8 PATHWAY AND SUPPRESSING THE NF-kappaB PATHWAY.
Neoplasms
Coronarin D induces human oral cancer cell apoptosis though upregulate JNK1/2 signaling pathway.
Neoplasms
CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme.
Neoplasms
CR-LAAO, an L-amino acid oxidase from Calloselasma rhodostoma venom, as a potential tool for developing novel immunotherapeutic strategies against cancer.
Neoplasms
CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.
Neoplasms
Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells.
Neoplasms
Critical role of the death receptor pathway in the antitumoral effects induced by hispanolone derivatives.
Neoplasms
Crosstalk Between Apoptosis and Autophagy Is Regulated by the Arginylated BiP/Beclin-1/p62 Complex.
Neoplasms
CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction.
Neoplasms
Cucurbita ficifolia Fruit Extract Induces Tp53/Caspase-Mediated Apoptosis in MCF-7 Breast Cancer Cells.
Neoplasms
CUDC-907 enhances TRAIL-induced apoptosis through upregulation of DR5 in breast cancer cells.
Neoplasms
Cutting edge: bortezomib-treated tumors sensitized to NK cell apoptosis paradoxically acquire resistance to antigen-specific T cells.
Neoplasms
Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line.
Neoplasms
Cytotoxicity of a newly synthesized nitroxide derivative of 4-ferrocenecarboxyl-2,2,6,6-tetramethylpiperidine-1-oxyl in high metastatic lung tumor cells.
Neoplasms
DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells.
Neoplasms
Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8.
Neoplasms
Decrease in intracellular superoxide sensitizes Bcl-2-overexpressing tumor cells to receptor and drug-induced apoptosis independent of the mitochondria.
Neoplasms
Deguelin targets multiple oncogenic signaling pathways to combat human malignancies.
Neoplasms
Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt.
Neoplasms
Deletion and aberrant CpG island methylation of Caspase 8 gene in medulloblastoma.
Neoplasms
Delineating an Epigenetic Continuum for Initiation, Transformation and Progression to Breast Cancer.
Neoplasms
Dendritic cell-induced apoptosis of human cytomegalovirus-infected fibroblasts promotes cross-presentation of pp65 to CD8+ T cells.
Neoplasms
Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production.
Neoplasms
Depletion of membrane cholesterol compromised caspase-8 imparts in autophagy induction and inhibition of cell migration in cancer cells.
Neoplasms
Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein.
Neoplasms
Design, synthesis, and biological evaluation of new challenging thalidomide analogs as potential anticancer immunomodulatory agents.
Neoplasms
Detecting promoter methylation pattern of apoptotic genes Apaf1 and Caspase8 in gastric carcinoma patients undergoing chemotherapy.
Neoplasms
Detection of CpG island hypermethylation of caspase-8 in neuroblastoma using an oligonucleotide array.
Neoplasms
Detection of High-Risk Human Papillomavirus in Oral Cavity Squamous Cell Carcinoma Using Multiple Analytes and Their Role in Patient Survival.
Neoplasms
DIABLO/SMAC mimetics selectively kill HIV-1-infected resting memory CD4+ T cells: a potential role in a cure strategy for HIV-1 infection.
Neoplasms
Diallyl trisulfide increases the effectiveness of TRAIL and inhibits prostate cancer growth in an orthotopic model: molecular mechanisms.
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Differences in the mechanisms of action of BDE-47 and its metabolites on OVCAR-3 and MCF-7 cell apoptosis.
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Differential expression of intracellular apoptotic signaling molecules in tumor and tumor-infiltrating lymphocytes during development of invasion and/or metastasis of gastric carcinoma.
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Differential protection with inhibitors of caspase-8 and caspase-3 in murine models of tumor necrosis factor and Fas receptor-mediated hepatocellular apoptosis.
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Differential protein expression between esophageal squamous cell carcinoma and dysplasia, and prognostic significance of protein markers.
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Differential recruitment of caspase 8 to cFlip confers sensitivity or resistance to Fas-mediated apoptosis in a subset of familial lymphoma patients.
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Distinct Immune Imprints of Post-Liver Transplantation Hepatitis C Persist Despite Viral Clearance.
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DNA methylation of multiple genes in vestibular schwannoma: Relationship with clinical and radiological findings.
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DNA Methylation profiles as predictors of recurrence in non muscle invasive bladder cancer: an MS-MLPA approach.
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DNA methylation-mediated caspase-8 downregulation is associated with anti-apoptotic activity and human malignant glioma grade.
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DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin.
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Down-regulation of c-FLIP Enhances death of cancer cells by smac mimetic compound.
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Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance.
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Downmodulation of dimethyl transferase activity enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in prostate cancer cells.
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Downregulation of Caspase 8 in a group of Iranian breast cancer patients - A pilot study.
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Downregulation of cyclooxygenase-1 is involved in gastric mucosal apoptosis via death signaling in portal hypertensive rats.
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Doxorubicin sensitizes human tumor cells to NK and T cell-mediated killing by augmented TRAIL-receptor signaling.
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Doxorubicin-induced death in neuroblastoma does not involve death receptors in S-type cells and is caspase-independent in N-type cells.
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DR5-Cbl-b/c-Cbl-TRAF2 complex inhibits TRAIL-induced apoptosis by promoting TRAF2-mediated polyubiquitination of caspase-8 in gastric cancer cells.
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dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8.
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E1A-induced processing of procaspase-8 can occur independently of FADD and is inhibited by Bcl-2.
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Effect-enhancing and toxicity-reducing activity of usnic acid in ascitic tumor-bearing mice treated with bleomycin.
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Effects of chlorella on activities of protein tyrosine phosphatases, matrix metalloproteinases, caspases, cytokine release, B and T cell proliferations, and phorbol ester receptor binding.
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Effects of chronic ethanol drinking on the blood brain barrier and ensuing neuronal toxicity in alcohol-preferring rats subjected to intraperitoneal LPS injection.
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Effects of early administration of insulin-like growth factor-1 on cognitive function in septic encephalopathy.
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Effects of etanercept on the apoptosis of ganglion cells and expression of Fas, TNF-?, caspase-8 in the retina of diabetic rats.
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Effects of Recombinant Circularly Permuted Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) (Recombinant Mutant Human TRAIL) in Combination with 5-Fluorouracil in Human Colorectal Cancer Cell Lines HCT116 and SW480.
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Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model.
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Effects of selective nitric oxide synthase inhibition on IGF-1, caspases and cytokines in a newborn piglet model of perinatal hypoxia-ischaemia.
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Effects of trans-resveratrol on type 1 diabetes-induced up-regulation of apoptosis and mitogen-activated protein kinase signaling in retinal pigment epithelium of Dark Agouti rats.
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Effects of treatment of rats with indole-3-carbinol on apoptosis in the mammary gland and mammary adenocarcinomas.
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Effects of Zhichan powder on signal transduction and apoptosis-associated gene expression in the substantia nigra of Parkinson's disease rats.
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Efficient eradication of hormone-resistant human prostate cancers by inactivated Sendai virus particle.
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Electroacupuncture inhibits apoptosis of splenic lymphocytes in traumatized rats through modulation of the TNF-?/NF-?B signaling pathway.
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EMT phenotype is induced by increased Src kinase activity via Src-mediated caspase-8 phosphorylation.
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Enhanced antitumor effect of combining TRAIL and MnSOD mediated by CEA-controlled oncolytic adenovirus in lung cancer.
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Enhancement of antitumor properties of TRAIL by targeted delivery to the tumor neovasculature.
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Enhancement of chemosensitivity in 5-fluorouracil-resistant colon cancer cells with carcinoembryonic antigen-specific RNA aptamer.
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Enhancement of lexatumumab-induced apoptosis in human solid cancer cells by Cisplatin in caspase-dependent manner.
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EphB4 provides survival advantage to squamous cell carcinoma of the head and neck.
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Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cells.
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Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines.
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Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer.
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Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhood.
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Erlotinib induces mitochondrial-mediated apoptosis in human H3255 non-small-cell lung cancer cells with epidermal growth factor receptorL858R mutation through mitochondrial oxidative phosphorylation-dependent activation of BAX and BAK.
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Estrogen-induced dimerization and activation of ER?-fused caspase-8: Artificial reversal of the estrogenic hormone effect in carcinogenesis.
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Ethanolic extracts of Pluchea indica (L.) leaf pretreatment attenuates cytokine-induced ?-cell apoptosis in multiple low-dose streptozotocin-induced diabetic mice.
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Euphorbiae humifusae induces apoptosis in Hep3B hepatocarcinoma cells via simultaneous activation of the death receptor-mediated and mitochondrial pathways.
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Evaluation of a subset of tumor suppressor gene for copy number and epigenitic changes in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma carcinogenesis.
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Evaluation of anti-tumorigenic activity of BP3B against colon cancer with patient-derived tumor xenograft model.
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Evaluation of caspase-3 and caspase-8 deregulation in tongue squamous cell carcinoma, based on immunohistochemistry and computerised image analysis.
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Evaluation of redox and bioenergetics states in the liver of vitamin A-treated rats.
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Evaluation of the Potential Diagnostic Utility of the Determination of Selected Caspases-Markers Involved in the Regulation of Apoptosis-In Patients with Ovarian Cancer.
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Exome sequencing of oral squamous cell carcinoma in users of Arabian snuff reveals novel candidates for driver genes.
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Expression and prognostic significance of APAF-1, caspase-8 and caspase-9 in stage II/III colon carcinoma: Caspase-8 and caspase-9 is associated with poor prognosis.
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Expression level of c-FLIP versus Fas determines susceptibility to Fas ligand-induced cell death in murine thymoma EL-4 cells.
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Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma.
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Expression levels of EPHB4, EFNB2 and caspase-8 are associated with clinicopathological features and progression of esophageal squamous cell cancer.
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Expression of 6 Common Antigenic Markers in Invasive Ductal Breast Carcinoma: Potential Clinical Implications.
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Expression of carbohydrate-antigen sialyl-Lewis a on colon cancer cells promotes xenograft growth and angiogenesis in nude mice.
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Expression of caspases-3, -6 and -8 and their relation to apoptosis in non-small cell lung carcinoma.
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Expression of cellular FLICE inhibitory protein, caspase-8, and protease inhibitor-9 in Ewing sarcoma and implications for susceptibility to cytotoxic pathways.
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Expression of concern: Shivapurkar et al., "Differential Inactivation of Caspase-8 in Lung Cancers", Cancer Biol Ther 2002; 1:65-9.
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Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures.
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Extracellular Caspase-8 Dependent Apoptosis on HeLa Cancer Cells and MRC-5 Normal Cells by ICD-85 (Venom Derived Peptides).
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Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.
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FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells.
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FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.
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FADD-dependent apoptosis induction in Jurkat leukemia T-cells by the resveratrol analogue, 3,4,5-trihydroxy-trans-stilbene.
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Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.
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FAM60A promotes cisplatin resistance in lung cancer cells by activating SKP2 expression.
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Fas, FasL, and cleaved caspases 8 and 3 in glioblastomas: A tissue microarray-based study.
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Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway.
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Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis.
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Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5.
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Fas-independent apoptosis induced by UVC in p53-mutated human epithelial tumor A431 cells through activation of caspase-8 and JNK/SAPK.
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Fas-mediated apoptosis in neuroblastoma requires mitochondrial activation and is inhibited by FLICE inhibitor protein and Bcl-2.
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Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.
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Features of the Copy Number Variation of Certain Genes in Tumor Cells in Patients with Serous Ovarian Adenocarcinoma.
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Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma.
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Fermentation Product of Soybean, Black Bean, and Green Bean Mixture Induces Apoptosis in a Wide Variety of Cancer Cells.
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FG020326 sensitized multidrug resistant cancer cells to docetaxel-mediated apoptosis via enhancement of caspases activation.
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Fibronectin protects lung cancer cells against docetaxel-induced apoptosis by promoting Src and caspase-8 phosphorylation.
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Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer.
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Formyl peptide receptor-2 is decreased in foetal growth restriction and contributes to placental dysfunction.
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FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastoma.
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Functional polymorphisms in FAS, FASL and CASP8 genes and risk of childhood acute lymphoblastic leukemia: a case-control study.
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GABA tea prevents cardiac fibrosis by attenuating TNF-alpha and Fas/FasL-mediated apoptosis in streptozotocin-induced diabetic rats.
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Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins.
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Gene-viro-therapy targeting liver cancer by a dual-regulated oncolytic adenoviral vector harboring IL-24 and TRAIL.
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Genetic and immune predictors for hypersensitivity syndrome to antiepileptic drugs.
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Genetic polymorphisms of the CASP8 gene promoter may not be associated with colorectal cancer in Han Chinese from southwest China.
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Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma.
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Genetic variants in cell death pathway genes and HBV-related hepatocellular carcinoma among a Chinese Han population.
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Genome-wide association analysis identifies genetic correlates of immune infiltrates in solid tumors.
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Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies.
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Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells.
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Glucosamine Enhances TRAIL-Induced Apoptosis in the Prostate Cancer Cell Line DU145.
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Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells.
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Glucuronorhamnoxylan from Capsosiphon fulvescens inhibits the growth of HT-29 human colon cancer cells in vitro and in vivo via induction of apoptotic cell death.
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Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway.
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GSK-3? signaling determines autophagy activation in the breast tumor cell line MCF7 and inclusion formation in the non-tumor cell line MCF10A in response to proteasome inhibition.
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HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL.
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Heat shock and tumor necrosis factor-alpha induce apoptosis in bovine preimplantation embryos through a caspase-9-dependent mechanism.
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Hepatitis C Virus Core Protein Inhibits Tumor Necrosis Factor Alpha-Mediated Apoptosis by a Protective Effect Involving Cellular FLICE Inhibitory Protein.
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Hepatocarcinoma Induces a Tumor Necrosis Factor-Dependent Kupffer Cell Death Pathway That Favors Its Proliferation Upon Partial Hepatectomy.
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Heterogeneity of primary glioblastoma cells in the expression of caspase-8 and the response to TRAIL-induced apoptosis.
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Heterogeneous role of caspase-8 in fenretinide-induced apoptosis in epithelial ovarian carcinoma cell lines.
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HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo.
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High level of cFLIP correlates with resistance to death receptor-induced apoptosis in bladder carcinoma cells.
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High Mannose Binding Lectin (PFL) from Pseudomonas fluorescens Down-Regulates Cancer-Associated Integrins and Immune Checkpoint Ligand B7-H4.
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High maternal milk intake in the postnatal life reduces the incidence of breast cancer during adulthood in rats.
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High sensitivity of ovarian cancer cells to the synthetic triterpenoid CDDO-Imidazolide.
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High-intensity focused ultrasound enhances the effect of bufalin by inducing apoptosis in pancreatic cancer cells.
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Hippophae rhamnoides polysaccharides protect IPEC-J2 cells from LPS-induced inflammation, apoptosis and barrier dysfunction in vitro via inhibiting TLR4/NF-?B signaling pathway.
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Hispolon Induces Apoptosis through JNK1/2-mediated Activation of a Caspase-8, -9, and -3-dependent Pathway in Acute Myeloid Leukemia (AML) Cells and Inhibits AML Xenograft Tumor Growth in Vivo.
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Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis.
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Histone deacetylase inhibitor-mediated sensitization to TRAIL-induced apoptosis in childhood malignancies is not associated with upregulation of TRAIL receptor expression, but with potentiated caspase-8 activation.
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Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.
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Histone deacetylase inhibitors enhance Ad5-TRAIL killing of TRAIL-resistant prostate tumor cells through increased caspase-2 activity.
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Human amniotic membrane derived-mesenchymal stem cells induce C6 glioma apoptosis in vivo through the Bcl-2/caspase pathways.
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Human papilloma virus load and PD-1/PD-L1, CD8(+) and FOXP3 in anal cancer patients treated with chemoradiotherapy: Rationale for immunotherapy.
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Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model.
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Hypericin photo-induced apoptosis involves the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and activation of caspase-8.
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Hypermethylation of apoptotic genes as independent prognostic factor in neuroblastoma disease.
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Hypoxia-Inducible Factor 1-? (HIF-1?) Induces Apoptosis of Human Uterosacral Ligament Fibroblasts Through the Death Receptor and Mitochondrial Pathways.
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I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis.
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Identification and characterization of murine caspase-14, a new member of the caspase family.
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Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.
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Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis.
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Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling.
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IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway.
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Immunocytochemical detection of members of the caspase cascade of apoptosis in high-grade astrocytomas.
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Immunomodulatory, Apoptosis Induction and Antitumor Activities of Aqueous and Methanolic Extract of Calvatia Craniiformis in Mice Transfected with Murine Hepatocellular Carcinoma Cells.
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Immunoreactivity to caspase-3, caspase-7, caspase-8, and caspase-9 forms is frequently lost in human prostate tumors.
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Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer.
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Impact of the DNA methyltransferases expression on the methylation status of apoptosis-associated genes in glioblastoma multiforme.
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Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.
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In silico analysis reveals a shared immune signature in CASP8-mutated carcinomas with varying correlations to prognosis.
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In Vitro Study of the Anticancer Effects of Biotechnological Extracts of the Endangered Plant Species Satureja Khuzistanica.
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Inactivated Sendai Virus Strain Tianjin Induces Apoptosis in Breast Cancer MCF-7 Cells by Promoting Caspase Activation and Fas/FasL Expression.
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Increased expression of Apaf-1 and procaspase-3 and the functionality of intrinsic apoptosis apparatus in non-small cell lung carcinoma.
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Increased neuronal survival in the brainstem during liver injury: role of ?-aminobutyric acid and serotonin chitosan nanoparticles.
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Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)- and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3.
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Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis.
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Inducing Apoptosis of Cancer Cells Using Sea Pen Virgularia gustaviana Extract Which is Comparable to Cembrane Diterpene Sarcophine.
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Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol.
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Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells.
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Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity.
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Induction of caspase 8 by interferon gamma renders some neuroblastoma (NB) cells sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB.
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Induction of death receptor ligand-mediated apoptosis in epithelial ovarian carcinoma: The search for sensitizing agents.
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Induction of serum amyloid A genes is associated with growth and apoptosis of HC11 mammary epithelial cells.
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Induction of TNF-? signaling cascade in neonatal rat brain during propofol anesthesia.
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Induction of tumor necrosis factor by bryostatin 1 is involved in synergistic interactions with paclitaxel in human myeloid leukemia cells.
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Influence of caspases 8 and 9 gene promoter polymorphism on prostate cancer susceptibility and early development of hormone refractory prostate cancer.
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Inhibition of c-FLIP by RNAi enhances sensitivity of the human osteogenic sarcoma cell line U2OS to TRAIL-induced apoptosis.
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Inhibition of cathepsin S attenuates myocardial ischemia/reperfusion injury by suppressing inflammation and apoptosis.
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Inhibition of cell growth and potentiation of tumor necrosis factor-? (TNF-?)-induced apoptosis by a phenanthroindolizidine alkaloid antofine in human colon cancer cells.
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Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction.
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Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4.
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Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing.
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Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation.
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Inhibition of Methyltransferases Accelerates Degradation of cFLIP and Sensitizes B-Cell Lymphoma Cells to TRAIL-Induced Apoptosis.
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Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin.
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Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (-)-gossypol.
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Inhibitory Effect of Lentivirus-Mediated Gag-Caspase-8 on the Growth of HER-2-Overexpressing Primary Human Breast Cancer Cells.
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Inhibitory effects of rosmarinic acid on pterygium epithelial cells through redox imbalance and induction of extrinsic and intrinsic apoptosis.
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Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer.
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Integrated analysis of oral tongue squamous cell carcinoma identifies key variants and pathways linked to risk habits, HPV, clinical parameters and tumor recurrence.
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Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation.
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Interferon gamma enhances the effectiveness of tumor necrosis factor-related apoptosis-inducing ligand receptor agonists in a xenograft model of Ewing's sarcoma.
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Interferon regulatory factor-1-induced apoptosis mediated by a ligand-independent fas-associated death domain pathway in breast cancer cells.
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Interferon-gamma differentially regulates monocyte matrix metalloproteinase-1 and -9 through tumor necrosis factor-alpha and caspase 8.
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Interferon-gamma induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter.
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Interferon-gamma sensitizes resistant Ewing's sarcoma cells to tumor necrosis factor apoptosis-inducing ligand-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivity.
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Interferon-{gamma} Sensitizes Resistant Ewing's Sarcoma Cells to Tumor Necrosis Factor Apoptosis-Inducing Ligand-Induced Apoptosis by Up-Regulation of Caspase-8 Without Altering Chemosensitivity.
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Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer.
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Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL.
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Intracellular mechanisms mediating tocotrienol-induced apoptosis in neoplastic mammary epithelial cells.
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Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment.
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Investigation of the Inhibitory Effect of Platycodin D in Human Transitional Cell Carcinoma Cell Line 5637.
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Investigation of the protective role of chrysin within the framework of oxidative and inflammatory markers in experimental testicular ischaemia/reperfusion injury in rats.
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Involvement of caspase-8 in chemotherapy-induced apoptosis of patient derived leukemia cell lines independent of the death receptor pathway and downstream from mitochondria.
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Involvement of MnSOD Ala16Val polymorphism in epilepsy: A relationship with seizure type, inflammation, and metabolic syndrome.
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Ionizing radiation can overcome resistance to TRAIL in TRAIL-resistant cancer cells.
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Is there any potential link among caspase-8, p-p38 MAPK and bcl-2 in clear cell renal cell carcinomas? A comparative immunohistochemical analysis with clinical connotations.
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Ischemia elicits a coordinated expression of pro-survival proteins in mouse myocardium.
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Isolation of 4,4'-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma.
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ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells.
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Jinzhi protects lipopolysaccharide-treated mice against mortality by repairing intestinal mucosal barrier damage and intestinal microecology.
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Kadsura heteroclita stem ethanol extract protects against carbon tetrachloride-induced liver injury in mice via suppression of oxidative stress, inflammation, and apoptosis.
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Kaurane diterpene, kamebakaurin, inhibits NF-kappa B by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-kappa B target genes.
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Kushen flavonoids induce apoptosis in tumor cells by inhibition of NF-kappaB activation and multiple receptor tyrosine kinase activities.
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l-Tryptophan exhibits therapeutic function in a porcine model of dextran sodium sulfate (DSS)-induced colitis.
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Lentivirus-Based Virus-Like Particles Mediate Delivery of Caspase 8 into Breast Cancer Cells and Inhibit Tumor Growth.
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LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes.
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Linalool-Loaded Glutathione-Modified Gold Nanoparticles Conjugated with CALNN Peptide as Apoptosis Inducer and NF-?B Translocation Inhibitor in SKOV-3 Cell Line.
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Long-term administration of high-dose methylphenidate-induced cerebellar morphology and function damage in adult rats.
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Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis.
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Loss of caspase-8 expression does not correlate with MYCN amplification, aggressive disease, or prognosis in neuroblastoma.
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Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.
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Loss of caspase-8 expression in neuroblastoma is related to malignancy and resistance to TRAIL-induced apoptosis.
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Loss of caspase-8 mRNA expression is common in childhood primitive neuroectodermal brain tumour/medulloblastoma.
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Loss of caspase-8 protein expression correlates with unfavorable survival outcome in childhood medulloblastoma.
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Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification.
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Loss of FADD protein expression results in a biased Fas-signaling pathway and correlates with the development of tumoral status in thyroid follicular cells.
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Low P66shc with High SerpinB3 Levels Favors Necroptosis and Better Survival in Hepatocellular Carcinoma.
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Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.
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Low-dose bisphenol A induces RIPK1-mediated necroptosis in SH-SY5Y cells: Effects on TNF-? and acetylcholinesterase.
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MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells.
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Mao (Ephedra sinica Stapf) protects against D-galactosamine and lipopolysaccharide-induced hepatic failure.
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Mechanisms involved in Korean mistletoe lectin-induced apoptosis of cancer cells.
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Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra.
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Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus.
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Membrane-bound TRAIL supplements natural killer cell cytotoxicity against neuroblastoma cells.
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Menin-mediated Caspase 8 Expression in Suppressing Multiple Endocrine Neoplasia Type 1.
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Methods for simultaneous measurement of apoptosis and cell surface phenotype of epithelial cells in effusions by flow cytometry.
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Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome.
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Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer.
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Methylation of tumor-suppressor genes in neuroblastoma: The RASSF1A gene is almost always methylated in primary tumors.
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Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis.
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Methylation-specific multiplex ligation-dependent probe amplification and its impact on clinical findings in medulloblastoma.
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MicroRNA-519a-3p mediates apoptosis resistance in breast cancer cells and their escape from recognition by natural killer cells.
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Midkine protects hepatocellular carcinoma cells against TRAIL-mediated apoptosis through down-regulation of caspase-3 activity.
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miR-187-5p/apaf-1 axis was involved in oxidative stress-mediated apoptosis caused by ammonia via mitochondrial pathway in chicken livers.
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Mitochondrial pathway is responsible for aging-related increase of tubular cell apoptosis in renal ischemia/reperfusion injury.
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Mitochondrial transmembrane potential and reactive oxygen species generation regulate the enhanced effect of CCCP on TRAIL-induced SNU-638 cell apoptosis.
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MMTV-NeuT/ATTAC mice: a new model for studying the stromal tumor microenvironment.
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Molecular mechanism of Mitomycin C-dependent caspase-8 regulation: implications for apoptosis and synergism with interferon-alpha signalling.
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Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: role of calmodulin.
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Monte carlo study elucidates the type 1/type 2 choice in apoptotic death signaling in healthy and cancer cells.
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MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death.
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mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.
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MUC1 oncoprotein blocks death receptor-mediated apoptosis by inhibiting recruitment of caspase-8.
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Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in oligodendroglial tumors.
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Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation.
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Mutation Analysis of the Dimer Forming Domain of the Caspase 8 Gene in Oral Submucous Fibrosis and Squamous Cell Carcinomas.
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Mutational analysis of head and neck squamous cell carcinoma stratified by smoking status.
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Mutations in the P10 region of procaspase-8 lead to chemotherapy resistance in acute myeloid leukemia by impairing procaspase-8 dimerization.
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Mutations to bid cleavage sites protect hepatocytes from apoptosis after ischemia/reperfusion injury.
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Myenteric plexuses atrophy in the vicinity of colorectal cancer tissue is not caused by apoptosis or necrosis.
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Necroptosis occurs in osteoblasts during tumor necrosis factor-? stimulation and caspase-8 inhibition.
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NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling.
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Newcastle disease virus exerts oncolysis by both intrinsic and extrinsic caspase-dependent pathways of cell death.
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NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis.
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Nifuroxazide attenuates experimentally-induced hepatic encephalopathy and the associated hyperammonemia and cJNK/caspase-8/TRAIL activation in rats.
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Nitric oxide prevents tumor necrosis factor alpha-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8.
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NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing.
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NO-mesalamine protects colonic epithelial cells against apoptotic damage induced by proinflammatory cytokines.
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Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-?B activation.
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Novel 2-step synthetic indole compound 1,1,3-tri(3-indolyl)cyclohexane inhibits cancer cell growth in lung cancer cells and xenograft models.
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Novel noncatalytic role for caspase-8 in promoting SRC-mediated adhesion and Erk signaling in neuroblastoma cells.
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Novel polysaccharide extracted from Sipunculus nudus inhibits HepG2 tumour growth in vivo by enhancing immune function and inducing tumour cell apoptosis.
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Nuclear Expression of ?-Catenin Promotes RB Stability and Resistance to TNF-Induced Apoptosis in Colon Cancer Cells.
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Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity.
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O(2)-Vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate protection against D-galactosamine/endotoxin-induced hepatotoxicity in mice: genomic analysis using microarrays.
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Off-target lapatinib activity sensitizes colon cancer cells through TRAIL death receptor up-regulation.
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One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma.
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Overexpression of cellular FLICE-inhibitory protein (FLIP) in gastric adenocarcinoma.
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Overexpression of cellular repressor of E1A-stimulated genes inhibits TNF-?-induced apoptosis via NF-?B in mesenchymal stem cells.
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Oxidant stress evoked damage in rat hepatocyte leading to triggered nitric oxide synthase (NOS) levels on long term consumption of aspartame.
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Oxygen-charged HTK-F6H8 emulsion reduces ischemia-Reperfusion injury in kidneys from brain-dead Pigs.
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P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma.
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p53-dependent Fas expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells.
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p62/SQSTM1 is involved in caspase-8 associated cell death induced by proteasome inhibitor MG132 in U87MG cells.
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Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules.
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PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.
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Penehyclidine hydrochloride exerts protective effects in rats with acute lung injury via the Fas/FasL signaling pathway.
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Perfluorononanoic acid-induced apoptosis in rat spleen involves oxidative stress and the activation of caspase-independent death pathway.
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Peripheral Inflammation Accelerates the Onset of Mechanical Hypersensitivity after Spinal Cord Injury and Engages Tumor Necrosis Factor ? Signaling Mechanisms.
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pERK 1/2 inhibit Caspase-8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner.
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Peroxiredoxin 6 interferes with TRAIL-induced death-inducing signaling complex formation by binding to death effector domain caspase.
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Persian shallot, Allium hirtifolium Boiss, induced apoptosis in human hepatocellular carcinoma cells.
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Persistent inhibition of ABL tyrosine kinase causes enhanced apoptotic response to TRAIL and disrupts the pro-apoptotic effect of chloroquine.
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Phenalenone-photodynamic therapy induces apoptosis on human tumor cells mediated by caspase-8 and p38-MAPK activation.
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Phosphorylation of murine caspase-9 by the protein kinase casein kinase 2 regulates its cleavage by caspase-8.
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Phytosphingosine in combination with TRAIL sensitizes cancer cells to TRAIL through synergistic up-regulation of DR4 and DR5.
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Phytosphingosine induces apoptotic cell death via caspase 8 activation and Bax translocation in human cancer cells.
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Plasma Proteomic Analysis in Non-Small Cell Lung Cancer Patients Treated with PD-1/PD-L1 Blockade.
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Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy.
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Poly C Binding Protein 1 Regulates p62/SQSTM1 mRNA Stability and Autophagic Degradation to Repress Tumor Progression.
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Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population.
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Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults.
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Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin's lymphoma in Chinese patients.
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Polymorphisms of Caspase 8 and Caspase 9 gene and colorectal cancer susceptibility and prognosis.
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Polysaccharides Extracted from Rhizoma Pleionis Have Antitumor Properties In Vitro and in an H22 Mouse Hepatoma Ascites Model In Vivo.
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Possible mechanisms of Leukoagglutinin induced apoptosis in human cells in vitro.
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Posttranslational and Therapeutic Control of Gasdermin-Mediated Pyroptosis and Inflammation.
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Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells.
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Potential Molecular Mechanisms of Plantain in the Treatment of Gout and Hyperuricemia Based on Network Pharmacology.
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Prevalence of cancer susceptibility variants in patients with multiple Lynch syndrome related cancers.
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Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal.
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Proapoptotic PEDF functional peptides inhibit prostate tumor growth--a mechanistic study.
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Progesterone induces apoptosis by activation of caspase-8 and calcitriol via activation of caspase-9 pathways in ovarian and endometrial cancer cells in vitro.
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Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer.
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Prognostic significance of TRAIL signaling molecules in stage II and III colorectal cancer.
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Prognostic value of quantifying apoptosis factor expression in favorable histology wilms tumors.
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Programmed delivery of cyclopeptide RA-V and antisense oligonucleotides for combination therapy on hypoxic tumors and for therapeutic self-monitoring.
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Proliferation index: a continuous model to predict prognosis in patients with tumours of the Ewing's sarcoma family.
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Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling.
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Promoter methylation pattern of caspase-8, P16INK4A, MGMT, TIMP-3, and E-cadherin in medulloblastoma.
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Proteasome inhibition blocks caspase-8 degradation and sensitizes prostate cancer cells to death receptor-mediated apoptosis.
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Proteasome inhibition can impair caspase-8 Activation upon sub-maximal Stimulation of apoptotic tumour necrosis factor-related apoptosis inducing ligand (TRAIL) signalling.
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Proteins from Lignosus tigris with selective apoptotic cytotoxicity towards MCF7 cell line and suppresses MCF7-xenograft tumor growth.
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Proteomic analysis of novel targets associated with the enhancement of TrkA-induced SK-N-MC cancer cell death caused by NGF.
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Protumorigenic Activity of Plasminogen Activator Inhibitor-1 Through an Antiapoptotic Function.
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PTHrP Expression in Human MDA-MB-231 Breast Cancer Cells Is Critical for Tumor Growth and Survival and Osteoblast Inhibition.
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Purified compounds from marine organism sea pen induce apoptosis in human breast cancer cell MDA-MB-231 and cervical cancer cell Hela.
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Quantitative global and gene-specific promoter methylation in relation to biological properties of neuroblastomas.
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RASSF1A methylation may have two biological roles in neuroblastoma tumorigenesis depending on the ploidy status and age of patients.
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RbAp48 is a critical mediator controlling the transforming activity of human papillomavirus type 16 in cervical cancer.
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Recurrent patterns of DNA methylation in the ZNF154, CASP8, and VHL promoters across a wide spectrum of human solid epithelial tumors and cancer cell lines.
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Reduced expression of caspase-8 and cleaved caspase-3 in pancreatic ductal adenocarcinoma cells.
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Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice.
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Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis.
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Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene.
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Regulation of the expression of tumor necrosis factor?related genes by abnormal histone H3K27 acetylation: Implications for neural tube defects.
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Regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by DJ-1 in thyroid cancer cells.
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Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells.
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Repeated hepatocyte growth factor neutralizing antibody treatment leads to HGF/SF unresponsiveness in human glioblastoma multiforme cells.
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Repurposing the serotonin agonist Tegaserod as an anticancer agent in melanoma: molecular mechanisms and clinical implications.
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Requirement of nuclear factor ?B for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis.
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Rescue of early-stage myelodysplastic syndrome-deriving erythroid precursors by the ectopic expression of a dominant-negative form of FADD.
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RESISTANCE TO FAS-MEDIATED APOPTOSIS IN MALIGNANT TUMOURS IS RESCUED BY KN-93 AND CISPLATIN VIA DOWNREGULATION OF c-FLIP EXPRESSION AND PHOSPHORYLATION.
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Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.
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Retinoic acid induces caspase-8 transcription via phospho-CREB and increases apoptotic responses to death stimuli in neuroblastoma cells.
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Rhein Augments Antiproliferative Effects of Atezolizumab Based on Breast Cancer (4T1) Regression.
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RNA expression profiling of normal and tumor cells following photodynamic therapy with 5-aminolevulinic acid-induced protoporphyrin IX in vitro.
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Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation.
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Role of caspase 8 as a determinant in trail sensitivity of neuroblastoma cell lines.
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Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors.
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Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway.
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SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma.
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Sann-Joong-Kuey-Jian-Tang decreases the protein expression of Mcl?1 and TCTP and increases that of TNF-? and Bax in BxPC?3 pancreatic carcinoma cells.
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Sann-Joong-Kuey-Jian-Tang inhibits hepatocellular carcinoma Hep-G2 cell proliferation by increasing TNF-?, Caspase-8, Caspase- 3 and Bax but by decreasing TCTP and Mcl-1 expression in vitro.
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Sann-Joong-Kuey-Jian-Tang up-regulates the protein expression of Fas and TNF-? in colo 205 cells in vivo and in vitro.
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SB203580 Modulates p38 MAPK Signaling and Dengue Virus-Induced Liver Injury by Reducing MAPKAPK2, HSP27, and ATF2 Phosphorylation.
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Searching in mother nature for anti-cancer activity: anti-proliferative and pro-apoptotic effect elicited by green barley on leukemia/lymphoma cells.
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Secretory leukoprotease inhibitor inhibits cell growth through apoptotic pathway on ovarian cancer.
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Selective in situ protein expression profiles correlate with distinct phenotypes of basal cell carcinoma and squamous cell carcinoma of the skin.
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Sensitivity of prostate cells to TRAIL-induced apoptosis increases with tumor progression: DR5 and caspase 8 are key players.
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Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer.
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Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis.
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Shear stress promotes anoikis resistance of cancer cells via caveolin-1-dependent extrinsic and intrinsic apoptotic pathways.
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shRNA mediated RHOXF1 silencing influences expression of BCL2 but not CASP8 in MCF-7 and MDA-MB-231 cell lines.
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Shwachman-Bodian-Diamond syndrome protein desensitizes breast cancer cells to apoptosis in stiff matrices by repressing the caspase 8-mediated pathway.
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Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): caspase-8 is required for TRAIL-induced apoptosis.
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Significant inhibition of TRAIL-mediated fibroblast-like synovial cell apoptosis by IFN-gamma through JAK/STAT pathway by translational regulation.
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Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation.
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Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion.
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Single CpG island methylation is not sufficient to maintain the silenced expression of CASPASE-8 apoptosis-related gene among women with epithelial ovarian cancer.
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Sinoporphyrin Sodium-Mediated Sonodynamic Therapy Inhibits RIP3 Expression and Induces Apoptosis in the H446 Small Cell Lung Cancer Cell Line.
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SLIT2 promoter methylation analysis in neuroblastoma, Wilms' tumour and renal cell carcinoma.
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Smac-mimetic enhances antitumor effect of standard chemotherapy in ovarian cancer models via Caspase 8-independent mechanism.
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Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.
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Soluble factors released by activated cytotoxic T lymphocytes interfere with death receptor pathways in neuroblastoma.
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Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells.
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Staphylococcus aureus - induced tumor necrosis factor - related apoptosis - inducing ligand expression mediates apoptosis and caspase-8 activation in infected osteoblasts.
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Stomach cancer highly expresses both initiator and effector caspases; an immunohistochemical study.
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Structural insights of homotypic interaction domains in the ligand-receptor signal transduction of tumor necrosis factor (TNF).
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Structure, cytotoxic activity and mechanism of protoilludane sesquiterpene aryl esters from the mycelium of Armillaria mellea.
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Stryphnodendron adstringens ("Barbatimão") Leaf Fraction: Chemical Characterization, Antioxidant Activity, and Cytotoxicity Towards Human Breast Cancer Cell Lines.
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Study of Caspase 8 mutation in oral cancer and adjacent precancer tissues and implication in progression.
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Study of RNA Interference Targeting NET-1 Combination with Sorafenib for Hepatocellular Carcinoma Therapy In Vitro and In Vivo.
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Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-? through up-regulation of TNF receptor 1 in lung cancer cells.
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Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2.
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Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling.
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Suppression of mammary gland carcinogenesis by post-initiation treatment of rats with tamoxifen or indole-3-carbinol or their combination.
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Suppression of NF-kappa B survival signaling by nitrosylcobalamin sensitizes neoplasms to the anti-tumor effects of Apo2L/TRAIL.
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Suramin decreases injury and improves regeneration of ethanol-induced steatotic partial liver grafts.
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Survivin mRNA levels are associated with biology of disease and patient survival in neuroblastoma: a report from the children's oncology group.
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Survivin-3B promotes chemoresistance and immune escape by inhibiting caspase-8 and -6 in cancer cells.
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Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders.
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Synergistic Effect of Celecoxib on TRAIL-induced Apoptosis in Hepatocellular Carcinoma Cells.
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Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways.
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Synergistic induction of apoptosis in neuroblastoma cells using a combination of cytostatic drugs with interferon-gamma and TRAIL.
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Synergistic role of Caspase-8 and Caspase-3 expressions: Prognostic and predictive biomarkers in colorectal cancer.
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Synergistic tumor suppression by adenovirus-mediated inhibitor of growth 4 and interleukin-24 gene cotransfer in hepatocarcinoma cells.
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Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma.
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Synthesis of D-ring annulated pyridosteroids from ?-formyl enamides and their biological evaluations.
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Synthesis of Tolmetin Hydrazide-Hydrazones and Discovery of a Potent Apoptosis Inducer in Colon Cancer Cells.
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Systemic Inflammatory Protein Profiles Distinguish Irritable Bowel Syndrome (IBS) and Ulcerative Colitis, Irrespective of Inflammation or IBS-Like Symptoms.
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Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenograft models of metastatic colorectal cancer.
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Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways.
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Targeting of miR-20a against CFLAR to potentiate TRAIL-induced apoptotic sensitivity in HepG2 cells.
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Targeting pancreatic cancer cells by a novel hydroxamate-based histone deacetylase (HDAC) inhibitor ST-3595.
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Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes.
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Targeting the short form of cFLIP by RNA interference is sufficient to enhance TRAIL sensitivity in PC3 prostate carcinoma cells.
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Targeting the tumor necrosis factor-related apoptosis-inducing ligand path in neuroblastoma.
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TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia.
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The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway.
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The anti-cancer drug etoposide can induce caspase-8 processing and apoptosis in the absence of CD95 receptor-ligand interaction.
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The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells.
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The apoptotic effects of Brucea javanica fruit extract against HT29 cells associated with p53 upregulation and inhibition of NF-?B translocation.
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The bioactive ingredients in Actinidia chinensis Planch. Inhibit liver cancer by inducing apoptosis.
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The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study.
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The chinese herbal medicine Tien-Hsien liquid inhibits cell growth and induces apoptosis in a wide variety of human cancer cells.
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The critical role of autophagy in cadmium-induced immunosuppression regulated by endoplasmic reticulum stress-mediated calpain activation in RAW264.7 mouse monocytes.
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The cytoprotective effects of addition of activated protein C into preservation solution on small-for-size grafts in rats.
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The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas.
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The Deubiquitinase Inhibitor PR-619 Sensitizes Normal Human Fibroblasts to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-mediated Cell Death.
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The dietary flavonol fisetin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells.
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The effects of vitamin A supplementation for 3 months on adult rat nigrostriatal axis: Increased monoamine oxidase enzyme activity, mitochondrial redox dysfunction, increased ?-amyloid(1-40) peptide and TNF-? contents, and susceptibility of mitochondria to an in vitro H(2)O(2) challenge.
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The Escalation of Osteosarcoma Stem Cells Apoptosis After the Co-Cultivation of Peripheral Blood Mononuclear Cells Sensitized with Mesenchymal Stem Cells Secretome and Colony Stimulating Factor-2 in vitro.
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The essential role of the mitochondria-dependent death-signaling cascade in chemotherapy-induced potentiation of Apo2L/TRAIL cytotoxicity in cultured thoracic cancer cells: amplified caspase 8 is indispensable for combination-mediated massive cell death.
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The expressions of intrinsic and extrinsic apoptotic pathway proteins in neutrophils of oral cavity cancer patients: a preliminary study.
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The extrinsic apoptotic signaling pathway in gastric adenocarcinomas assessed by tissue microarray.
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The FAS-related apoptosis signaling pathway in the prostate intraepithelial neoplasia and cancer lesions.
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The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8.
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The human caspase-8 promoter sustains basal activity through SP1 and ETS-like transcription factors and can be up-regulated by a p53-dependent mechanism.
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The human cytomegalovirus-encoded chemokine receptor US28 induces caspase-dependent apoptosis.
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The interaction between the light source dose and caspase-dependent and -independent apoptosis in human SK-MEL-3 skin cancer cells following photodynamic therapy with zinc phthalocyanine: A comparative study.
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The mitochondria-targeting antioxidant MitoQ alleviated Lipopolysaccharide/ D-galactosamine-induced acute liver injury in mice.
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The molecular effects of aloe-emodin (AE)/liposome-AE on human nonmelanoma skin cancer cells and skin permeation.
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The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway.
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The mutational spectrum of squamous-cell carcinoma of the head and neck: Targetable genetic events and clinical impact.
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The N-myc paradox: N-myc overexpression in neuroblastomas is associated with sensitivity as well as resistance to apoptosis.
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The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells.
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The newly synthesized anticancer drug HUHS1015 is useful for treatment of human gastric cancer.
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The Novel Akt Inhibitor API-1 Induces c-FLIP Degradation and Synergizes with TRAIL to Augment Apoptosis Independent of Akt Inhibition.
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The novel camptothecin derivative, CPT211, induces cell cycle arrest and apoptosis in models of human breast cancer.
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The Proteomic Landscape of Growth Factor Signaling Networks Associated with FAT1 Mutations in Head and Neck Cancers.
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The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome.
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The relationship of CASP 8 polymorphism and cancer susceptibility: a meta-analysis.
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The Ribonucleotide Reductase R1 Subunits of Herpes Simplex Virus 1 and 2 Protect Cells against Poly(I {middle dot} C)-Induced Apoptosis.
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The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNF?- and FasL-induced apoptosis by interacting with caspase-8.
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The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs.
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The role of cellular flice inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer.
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The role of p53 and the CD95 (APO-1/Fas) death system in chemotherapy-induced apoptosis.
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The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer.
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The scorpion venom peptide BmKn2 induces apoptosis in cancerous but not in normal human oral cells.
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The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice.
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The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck.
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The universal NF-kappaB inhibitor a20 protects from transplant vasculopathy by differentially affecting apoptosis in endothelial and smooth muscle cells.
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Thiamine Alleviates High-Concentrate-Diet-Induced Oxidative Stress, Apoptosis, and Protects the Rumen Epithelial Barrier Function in Goats.
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Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1.
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Thymoquinone ameliorates testicular tissue inflammation induced by chronic administration of oral sodium nitrite.
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TNF-? produced by SEC2 mutant (SAM-3)-activated human T cells induces apoptosis of HepG2 cells.
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TNF-alpha mediates eosinophil cationic protein-induced apoptosis in BEAS-2B cells.
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Toll like receptor 4 signaling pathway participated in Salmonella lipopolysaccharide-induced spleen injury in young chicks.
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TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer.
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TRAIL death receptors DR4 and DR5 mediate cerebral microvascular endothelial cell apoptosis induced by oligomeric Alzheimer's A?.
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TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.
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TRAIL induces apoptosis but not necroptosis in colorectal and pancreatic cancer cells preferentially via the TRAIL-R2/DR5 receptor.
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TRAIL negatively regulates VEGF-induced angiogenesis via caspase-8-mediated enzymatic and non-enzymatic functions.
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TRAIL-induced survival and proliferation of SCLC cells is mediated by ERK and dependent on TRAIL-R2/DR5 expression in the absence of caspase-8.
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Transforming growth factor ?-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling.
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Transforming growth factor-beta1 inhibits all-trans retinoic acid-induced apoptosis.
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Treatment of chronic kidney disease using a traditional Chinese medicine, Flos Abelmoschus manihot (Linnaeus) Medicus (Malvaceae).
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Trichosanthin inhibits breast cancer cell proliferation in both cell lines and nude mice by promotion of apoptosis.
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Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4R? overexpressed melanoma models.
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Tumor necrosis factor alpha sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-kappaB.
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Tumor necrosis factor-alpha and Fas activate complementary Fas-associated death domain-dependent pathways that enhance apoptosis induced by gamma-irradiation.
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Tumor necrosis factor-alpha induces intrinsic apoptotic signaling during renal obstruction through truncated bid activation.
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Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway.
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Tumor necrosis factor-related apoptosis-inducing ligand inhibits the growth and aggressiveness of colon carcinoma via the exogenous apoptosis signaling pathway.
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Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathways.
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Tumor-induced apoptosis of T lymphocytes: elucidation of intracellular apoptotic events.
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Tumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: protection by curcumin.
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Tumour necrosis factor-mediated cell death pathways do not contribute to muscle fibre death in dystrophinopathies.
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Tuning of apoptosis-mediator gene transcription in HepG2 human hepatoma cells through an adenosine signal.
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Turmeric-based diet can delay apoptosis without modulating NF-kappaB in unilateral ureteral obstruction in rats.
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UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis.
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Understanding the Role of the Death Receptor 5/FADD/caspase-8 Death Signaling in Cancer Metastasis.
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Unexpected PD-L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies.
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Variation within three apoptosis associated genes as potential risk factors for Achilles tendinopathy in a British based case-control cohort.
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Venous congestion induces mucosal apoptosis via tumor necrosis factor-alpha-mediated cell death in the rat small intestine.
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Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy.
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Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent.
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[Antitumor Activity of TRAIL-Mu3 Protein in vitro and in vivo and the Mechanisms].
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[Apoptosis mechanism of taxol combined with resveratrol on human laryngeal carcinoma Hep-2 cells].
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[Bcl-xl blocks tumor necrosis factor alpha-induced caspase 8 activation and apoptosis]
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[Clinical and Functional Importance of Selected CASP8 and CASP9 Polymorphisms in Breast Carcinoma].
Neoplasms
[Effect of p38MAPK gene silencing on expression of oncogenes and apoptotic genes induced by PM(2.5) in hepatocytes].
Neoplasms
[FLIP--an enemy which might lose the battle against the specific inhibitors of translation]
Neoplasms
[Role of ?-toxin-induced apoptosis of umbilical vein endothelial cells in vertical infection of Staphylococcus aureus L-form].
Neoplasms
[Sitagliptin inhibits cell apoptosis and inflammation of renal tissues in diabetic nephropathy model rats].
Neoplasms
[Synergistic effects and mechanisms of combined tumor necrosis factor-related apoptosis-inducing ligand and chemotherapeutic drugs or radiotherapy in killing laryngeal squamous carcinoma cells in vitro]
Neoplasms
[The synergism and mechanism of action of rClone30-hDR5 in combination with TRAIL on HCC].
Neoplasms, Germ Cell and Embryonal
Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.
Neoplasms, Squamous Cell
Expression levels of EPHB4, EFNB2 and caspase-8 are associated with clinicopathological features and progression of esophageal squamous cell cancer.
Neoplasms, Squamous Cell
Human papilloma virus load and PD-1/PD-L1, CD8(+) and FOXP3 in anal cancer patients treated with chemoradiotherapy: Rationale for immunotherapy.
Nephritis
Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1-dependent caspase 8 activation.
Nephrotic Syndrome
The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia.
Neural Tube Defects
Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure.
Neural Tube Defects
Maternal Hyperglycemia Activates an ASK1-FoxO3a-Caspase 8 Pathway That Leads to Embryonic Neural Tube Defects.
Neurilemmoma
CpG island methylation in sporadic and neurofibromatis type 2-associated schwannomas.
Neuroblastoma
5-Aza-2'-deoxycytidine and IFN-gamma cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8.
Neuroblastoma
A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cells.
Neuroblastoma
Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma.
Neuroblastoma
Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell death.
Neuroblastoma
Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma.
Neuroblastoma
An interferon-sensitive response element is involved in constitutive caspase-8 gene expression in neuroblastoma cells.
Neuroblastoma
Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways.
Neuroblastoma
Association of RASSF1A, DCR2, and CASP8 Methylation with Survival in Neuroblastoma: A Pooled Analysis Using Reconstructed Individual Patient Data.
Neuroblastoma
Atypic SUMOylation of Nor1/NR4A3 regulates neural cell viability and redox sensitivity.
Neuroblastoma
CASP8 SNP D302H (rs1045485) Is Associated with Worse Survival in MYCN-Amplified Neuroblastoma Patients.
Neuroblastoma
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN.
Neuroblastoma
Caspase 8L, a novel inhibitory isoform of caspase 8, is associated with undifferentiated neuroblastoma.
Neuroblastoma
Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis.
Neuroblastoma
Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma.
Neuroblastoma
Caspase-8 expression and its Src-dependent phosphorylation on Tyr380 promote cancer cell neoplastic transformation and resistance to anoikis.
Neuroblastoma
Caspase-8 levels correlate with the expression of signal transducer and activator of transcription 1 in high-grade but not lower grade neuroblastoma.
Neuroblastoma
Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex.
Neuroblastoma
Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN.
Neuroblastoma
Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis.
Neuroblastoma
Combination of IFN? and Chemotherapeutic Agents Increase TRAIL Sensitivity of Neuroblastoma Cell Lines.
Neuroblastoma
Cytotoxic Effect of p-Coumaric Acid on Neuroblastoma, N2a Cell via Generation of Reactive Oxygen Species Leading to Dysfunction of Mitochondria Inducing Apoptosis and Autophagy.
Neuroblastoma
Detection of CpG island hypermethylation of caspase-8 in neuroblastoma using an oligonucleotide array.
Neuroblastoma
Distinct CpG methylation profiles characterize different clinical groups of neuroblastic tumors.
Neuroblastoma
Doxorubicin-induced apoptosis in caspase-8-deficient neuroblastoma cells is mediated through direct action on mitochondria.
Neuroblastoma
Doxorubicin-induced death in neuroblastoma does not involve death receptors in S-type cells and is caspase-independent in N-type cells.
Neuroblastoma
Enhanced cell cycle perturbation and apoptosis mediate the synergistic effects of ST1926 and ATRA in neuroblastoma preclinical models.
Neuroblastoma
Evaluation of IFN-gamma effects on apoptosis and gene expression in neuroblastoma--preclinical studies.
Neuroblastoma
Expression and methylation of CASP8 in neuroblastoma: identification of a promoter region.
Neuroblastoma
Expression of short-form caspase 8 correlates with decreased sensitivity to Fas-mediated apoptosis in neuroblastoma cells.
Neuroblastoma
Expression of the caspase-8 gene in neuroblastoma cells is regulated through an essential interferon-sensitive response element (ISRE).
Neuroblastoma
Fas-mediated apoptosis in neuroblastoma requires mitochondrial activation and is inhibited by FLICE inhibitor protein and Bcl-2.
Neuroblastoma
Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma.
Neuroblastoma
FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastoma.
Neuroblastoma
Induction of caspase 8 by interferon gamma renders some neuroblastoma (NB) cells sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB.
Neuroblastoma
Inhibition of N-myc expression sensitizes human neuroblastoma IMR-32 cells expressing caspase-8 to TRAIL.
Neuroblastoma
Interferon-gamma induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter.
Neuroblastoma
Introducing point mutations into the ATGs of the putative open reading frames of the HSV-1 gene encoding the latency associated transcript (LAT) reduces its anti-apoptosis activity.
Neuroblastoma
Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner.
Neuroblastoma
Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells.
Neuroblastoma
Lig-8, a highly bioactive lignophenol derivative from bamboo lignin, exhibits multifaceted neuroprotective activity.
Neuroblastoma
Loss of caspase-8 expression does not correlate with MYCN amplification, aggressive disease, or prognosis in neuroblastoma.
Neuroblastoma
Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.
Neuroblastoma
Loss of caspase-8 expression in neuroblastoma is related to malignancy and resistance to TRAIL-induced apoptosis.
Neuroblastoma
Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation.
Neuroblastoma
Membrane-bound TRAIL supplements natural killer cell cytotoxicity against neuroblastoma cells.
Neuroblastoma
Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome.
Neuroblastoma
Neuroblastoma epigenetics: From candidate gene approaches to genome-wide screenings.
Neuroblastoma
Neurotrophin p75 receptor is involved in neuronal damage by prion peptide-(106-126).
Neuroblastoma
Novel noncatalytic role for caspase-8 in promoting SRC-mediated adhesion and Erk signaling in neuroblastoma cells.
Neuroblastoma
PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.
Neuroblastoma
Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer.
Neuroblastoma
Promoter methylation pattern of caspase-8, P16INK4A, MGMT, TIMP-3, and E-cadherin in medulloblastoma.
Neuroblastoma
RASSF1A methylation may have two biological roles in neuroblastoma tumorigenesis depending on the ploidy status and age of patients.
Neuroblastoma
RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours.
Neuroblastoma
Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene.
Neuroblastoma
Resistance to TRAIL-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.
Neuroblastoma
Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.
Neuroblastoma
Restoration of TRAIL-induced apoptosis in a caspase-8-deficient neuroblastoma cell line by stable re-expression of caspase-8.
Neuroblastoma
Retinoic acid induces caspase-8 transcription via phospho-CREB and increases apoptotic responses to death stimuli in neuroblastoma cells.
Neuroblastoma
Role of caspase 8 as a determinant in trail sensitivity of neuroblastoma cell lines.
Neuroblastoma
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer.
Neuroblastoma
Soluble factors released by activated cytotoxic T lymphocytes interfere with death receptor pathways in neuroblastoma.
Neuroblastoma
Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway.
Neuroblastoma
Survivin mRNA levels are associated with biology of disease and patient survival in neuroblastoma: a report from the children's oncology group.
Neuroblastoma
Synergistic induction of apoptosis in neuroblastoma cells using a combination of cytostatic drugs with interferon-gamma and TRAIL.
Neuroblastoma
Targeting the tumor necrosis factor-related apoptosis-inducing ligand path in neuroblastoma.
Neuroblastoma
Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.
Neuroblastoma
The N-myc paradox: N-myc overexpression in neuroblastomas is associated with sensitivity as well as resistance to apoptosis.
Neuroblastoma
[5-azacytidine enhances anti-tumor efficacy of doxorubicin to neuroblastoma cell lines]
Neuroblastoma
[Role of caspase-8 and DR5 in TRAIL-induced apoptosis of neuroblastoma cells]
Neurodegenerative Diseases
Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants.
Neurodegenerative Diseases
Identification of Potent Caspase-8 Inhibitors from a Library of Fluorescent Natural Products Screened by an AIEgen-based Light-up Probe.
Neurodegenerative Diseases
Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson's disease.
Neurodegenerative Diseases
Structure based molecular inhibition of Caspase-8 for treatment of multi-neurodegenerative diseases using known natural compounds.
Neurodegenerative Diseases
Study of Caspase 8 Inhibition for the Management of Alzheimer's Disease: A Molecular Docking and Dynamics Simulation.
Neurodegenerative Diseases
Targeting Caspase 8: Using Structural and Ligand-Based Approaches to Identify Potential Leads for the Treatment of Multi-Neurodegenerative Diseases.
Neuroectodermal Tumors
5-Aza-2'-deoxycytidine and IFN-gamma cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8.
Neuroectodermal Tumors, Primitive
Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhood.
Neuroectodermal Tumors, Primitive
Loss of caspase-8 mRNA expression is common in childhood primitive neuroectodermal brain tumour/medulloblastoma.
Neuroectodermal Tumors, Primitive
Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression.
Neuroendocrine Tumors
The novel Raf inhibitor Raf265 decreases Bcl-2 levels and confers TRAIL-sensitivity to neuroendocrine tumour cells.
Neuroinflammatory Diseases
Inhibition of cathepsin L alleviates the microglia-mediated neuroinflammatory responses through caspase-8 and NF-?B pathways.
Neuroinflammatory Diseases
Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma.
Neuroinflammatory Diseases
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation.
Neuroma, Acoustic
Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults.
Neutropenia
Caspase 8 polymorphisms contribute to the prognosis of advanced lung adenocarcinoma patients after platinum-based chemotherapy.
Non-alcoholic Fatty Liver Disease
Corrigendum: Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates.
Non-alcoholic Fatty Liver Disease
MiR-150 deficiency ameliorated hepatosteatosis and insulin resistance in nonalcoholic fatty liver disease via targeting CASP8 and FADD-like apoptosis regulator.
Non-alcoholic Fatty Liver Disease
PPAR ? inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell.
Non-alcoholic Fatty Liver Disease
Roles of Fas/Fasl, Bcl-2/Bax, and Caspase-8 in rat nonalcoholic fatty liver disease pathogenesis.
Non-alcoholic Fatty Liver Disease
Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates.
Non-alcoholic Fatty Liver Disease
[Effects of three Wenyang Jianpi Tang on cell proliferation and apoptosis of nonalcoholic fatty liver cells].
Non-alcoholic Fatty Liver Disease
[Evaluation of endothelial function and estimation of the degree of apoptosis in patients with metabolic syndrome and non-alcoholic fatty liver disease].
Obesity
Pinch loss ameliorates obesity, glucose intolerance and fatty liver by modulating adipocyte apoptosis in mice.
Obesity
The coexistence of nocturnal sustained hypoxia and obesity additively increases cardiac apoptosis.
Obesity
[Evaluation of endothelial function and estimation of the degree of apoptosis in patients with metabolic syndrome and non-alcoholic fatty liver disease].
Obstetric Labor, Premature
Distinct molecular events suggest different pathways for preterm labor and premature rupture of membranes.
Optic Atrophy
Antiapoptotic and mitochondrial biogenetic effects of exercise training on ovariectomized hypertensive rat hearts.
Optic Atrophy, Autosomal Dominant
Arsenic-induced cardiotoxicity correlates with mitochondrial damage and trace elements imbalance in broiler chickens.
Optic Nerve Injuries
Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo.
Oral Submucous Fibrosis
Mutation Analysis of the Dimer Forming Domain of the Caspase 8 Gene in Oral Submucous Fibrosis and Squamous Cell Carcinomas.
Oropharyngeal Neoplasms
CASP8 (rs3834129) and CASP3 (rs4647601) polymorphisms in oropharynx cancer risk, tumor cell differentiation, and prognosis in a cohort of the Brazilian population.
Osteoarthritis
Comparing different physical factors on serum TNF-? levels, chondrocyte apoptosis, caspase-3 and caspase-8 expression in osteoarthritis of the knee in rabbits.
Osteoarthritis, Knee
Comparing different physical factors on serum TNF-? levels, chondrocyte apoptosis, caspase-3 and caspase-8 expression in osteoarthritis of the knee in rabbits.
Osteoarthritis, Knee
The effect of different treatment time of millimeter wave on chondrocyte apoptosis, caspase-3, caspase-8, and MMP-13 expression in rabbit surgically induced model of knee osteoarthritis.
Osteoarthritis, Knee
The effect of low-level laser to apoptosis of chondrocyte and caspases expression, including caspase-8 and caspase-3 in rabbit surgery-induced model of knee osteoarthritis.
Osteoarthritis, Knee
The effect of therapeutic ultrasound to apoptosis of chondrocyte and caspase-3 and caspase-8 expression in rabbit surgery-induced model of knee osteoarthritis.
Osteomyelitis
New discoveries in CRMO: IL-1?, the neutrophil, and the microbiome implicated in disease pathogenesis in Pstpip2-deficient mice.
Osteomyelitis
NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1?-mediated osteomyelitis.
Osteonecrosis
Immunomodulatory, Apoptosis Induction and Antitumor Activities of Aqueous and Methanolic Extract of Calvatia Craniiformis in Mice Transfected with Murine Hepatocellular Carcinoma Cells.
Osteosarcoma
Bcl-2 and caspase-8 related anoikis resistance in human osteosarcoma MG-63 cells.
Osteosarcoma
Betulin inhibits mTOR and induces autophagy to promote apoptosis in human osteosarcoma cell lines.
Osteosarcoma
Bid is cleaved upstream of caspase-8 activation during TRAIL-mediated apoptosis in human osteosarcoma cells.
Osteosarcoma
c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.
Osteosarcoma
Caspase-8 dependent osteosarcoma cell apoptosis induced by proteasome inhibitor MG132.
Osteosarcoma
Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma.
Osteosarcoma
ClC-5 Downregulation Induces Osteosarcoma Cell Apoptosis by Promoting Bax and tBid Complex Formation.
Osteosarcoma
Correlation between TRAIL and caspase-8 expression and their relationship with cell proliferation and apoptosis in human osteosarcoma.
Osteosarcoma
Interferon-gamma sensitizes osteosarcoma cells to Fas-induced apoptosis by up-regulating Fas receptors and caspase-8.
Osteosarcoma
MicroRNA-21 Inhibits the Apoptosis of Osteosarcoma Cell Line SAOS-2 Via Targeting Caspase-8.
Osteosarcoma
Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma.
Osteosarcoma
Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP.
Osteosarcoma
Synergistic apoptotic effect of crocin and cisplatin on osteosarcoma cells via caspase induced apoptosis.
Osteosarcoma
The effects of MEX3A knockdown on proliferation, apoptosis and migration of osteosarcoma cells.
Osteosarcoma
The Escalation of Osteosarcoma Stem Cells Apoptosis After the Co-Cultivation of Peripheral Blood Mononuclear Cells Sensitized with Mesenchymal Stem Cells Secretome and Colony Stimulating Factor-2 in vitro.
Osteosarcoma
The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism.
Osteosarcoma
Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway.
Ovarian Neoplasms
(-)-Asarinin from the Roots of Asarum sieboldii Induces Apoptotic Cell Death via Caspase Activation in Human Ovarian Cancer Cells.
Ovarian Neoplasms
Activation of caspase-8 is critical for sensitivity to cytotoxic anti-Fas antibody-induced apoptosis in human ovarian cancer cells.
Ovarian Neoplasms
Alpha2,3-sialyltransferase III knockdown sensitized ovarian cancer cells to cisplatin-induced apoptosis.
Ovarian Neoplasms
Apoptosis-related gene expression can predict the response of ovarian cancer cell lines to treatment with recombinant human TRAIL alone or combined with cisplatin.
Ovarian Neoplasms
Association of the Variants CASP8 D302H and CASP10 V410I with Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
Ovarian Neoplasms
Breast cancer susceptibility variants alter risk in familial ovarian cancer.
Ovarian Neoplasms
Caspase 8 expression may determine the survival of women with ovarian cancer.
Ovarian Neoplasms
Effect of Amino Acids on the Generation of Ginsenoside Rg3 Epimers by Heat Processing and the Anticancer Activities of Epimers in A2780 Human Ovarian Cancer Cells.
Ovarian Neoplasms
Evaluation of the Potential Diagnostic Utility of the Determination of Selected Caspases-Markers Involved in the Regulation of Apoptosis-In Patients with Ovarian Cancer.
Ovarian Neoplasms
High sensitivity of ovarian cancer cells to the synthetic triterpenoid CDDO-Imidazolide.
Ovarian Neoplasms
Human beta-galactoside alpha-2,3-sialyltransferase (ST3Gal III) attenuated Taxol-induced apoptosis in ovarian cancer cells by downregulating caspase-8 activity.
Ovarian Neoplasms
Induction of death receptor ligand-mediated apoptosis in epithelial ovarian carcinoma: The search for sensitizing agents.
Ovarian Neoplasms
Inhibition of TRAIL-induced apoptosis by IL-8 is mediated by the p38-MAPK pathway in OVCAR3 cells.
Ovarian Neoplasms
Long isoform cellular FLICE inhibitory protein expression defines two ovarian cancer patient subsets and is a prognostic factor of adverse outcome.
Ovarian Neoplasms
Low penetrance alleles as risk modifiers in familial and sporadic breast cancer.
Ovarian Neoplasms
Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway.
Ovarian Neoplasms
p62 aggregates mediated Caspase 8 activation is responsible for progression of ovarian cancer.
Ovarian Neoplasms
Poly C Binding Protein 1 Regulates p62/SQSTM1 mRNA Stability and Autophagic Degradation to Repress Tumor Progression.
Ovarian Neoplasms
Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro.
Ovarian Neoplasms
Programmed cell death 4 enhances chemosensitivity of ovarian cancer cells by activating death receptor pathway in vitro and in vivo.
Ovarian Neoplasms
Smac-mimetic enhances antitumor effect of standard chemotherapy in ovarian cancer models via Caspase 8-independent mechanism.
Ovarian Neoplasms
Tanshinone IIA induces apoptosis of ovarian cancer cells in vitro and in vivo through attenuation of PI3K/AKT/JNK signaling pathways.
Ovarian Neoplasms
The extrinsic apoptosis pathway and its prognostic impact in ovarian cancer.
Ovarian Neoplasms
The iron chelator desferrioxamine synergizes with chemotherapy for cancer treatment.
Ovarian Neoplasms
Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway.
Overweight
Association Between Body Mass Index and Male Sperm Apoptosis and Apoptosis-Related Factors.
Pancreatic Neoplasms
A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivo.
Pancreatic Neoplasms
Absence of FLICE-Inhibitory Protein Is a Novel Independent Prognostic Marker for Very Short Survival in Pancreatic Ductal Adenocarcinoma.
Pancreatic Neoplasms
Anti-tumor effect by inhibition of NF-kappaB activation using nafamostat mesilate for pancreatic cancer in a mouse model.
Pancreatic Neoplasms
Anticancer effect of HOTTIP regulates human pancreatic cancer via the metabotropic glutamate receptor 1 pathway.
Pancreatic Neoplasms
Antipancreatic cancer effect of DNT cells and the underlying mechanism.
Pancreatic Neoplasms
Association of Breast Cancer Susceptibility Variants with Risk of Pancreatic Cancer.
Pancreatic Neoplasms
DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models.
Pancreatic Neoplasms
EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: Role of ROS accumulation, caspase-8 activation, and autophagy induction.
Pancreatic Neoplasms
Functional variants in cell death pathway genes and risk of pancreatic cancer.
Pancreatic Neoplasms
Gemcitabine-mediated apoptosis is associated with increased CD95 surface expression but is not inhibited by DN-FADD in Colo357 pancreatic cancer cells.
Pancreatic Neoplasms
Inhibition of RIP and c-FLIP enhances TRAIL-induced apoptosis in pancreatic cancer cells.
Pancreatic Neoplasms
Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death.
Pancreatic Neoplasms
Reduced expression of caspase-8 and cleaved caspase-3 in pancreatic ductal adenocarcinoma cells.
Pancreatic Neoplasms
Synthesis and biological evaluation of novel xanthine derivatives as potential apoptotic antitumor agents.
Pancreatic Neoplasms
Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.
Pancreatitis
Chrm3 protects against acinar cell necrosis by stabilizing caspase-8 expression in severe acute pancreatitis mice model.
Pancreatitis
Genetic Susceptibility in Acute Pancreatitis: Genotyping of GSTM1, GSTT1, GSTP1, CASP7, CASP8, CASP9, CASP10, LTA, TNFRSF1B, and TP53 Gene Variants.
Papilloma
Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice.
Papillomavirus Infections
CASP8 promoter polymorphism is associated with high-risk HPV types and abnormal cytology but not with cervical cancer.
Papillomavirus Infections
The combined risks of reduced or increased function variants in cell death pathway genes differentially influence cervical cancer risk and herpes simplex virus type 2 infection among black Africans and the Mixed Ancestry population of South Africa.
Paracoccidioidomycosis
Altered ex vivo expression of caspase 8, caspase 9 and Bcl-2 is associated with the T-cell hyporreactivity of paracoccidioidomycosis patients.
Paralysis
Dysequilibrium between caspases and their inhibitors in a mouse model for amyotrophic lateral sclerosis.
Parasitic Diseases
Fas/CD95-mediated apoptosis of type II cells is blocked by Toxoplasma gondii primarily via interference with the mitochondrial amplification loop.
Parkinson Disease
Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis.
Parkinson Disease
Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease.
Parkinson Disease
Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein.
Parkinson Disease
Effects of Zhichan powder on signal transduction and apoptosis-associated gene expression in the substantia nigra of Parkinson's disease rats.
Parkinson Disease
Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson's disease.
Parkinson Disease
Rifampicin protects PC12 cells against MPP+-induced apoptosis and inhibits the expression of an alpha-Synuclein multimer.
Parkinson Disease
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration.
Parotid Neoplasms
Bax, cytochrome c, and caspase-8 staining in parotid cancer patients: markers of susceptibility in radiotherapy?
Pemphigus
Caspase cascade pathways of apoptosis in oral pemphigus: An immunohistochemical study.
Pemphigus
Fas ligand in pemphigus sera induces keratinocyte apoptosis through the activation of caspase-8.
Penile Neoplasms
Mutational landscape of penile squamous cell carcinoma in a Chinese population.
Periodontal Diseases
The role of caspase-8, caspase-9, and apoptosis inducing factor in periodontal disease.
Periodontitis
Loss of periodontal ligament fibroblasts by RIPK3-MLKL-mediated necroptosis in the progress of chronic periodontitis.
Persistent Infection
Increased expressions of ADAMTS-13 and apoptosis contribute to neuropathology during Toxoplasma gondii encephalitis in mice.
Pheochromocytoma
Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl.
Pituitary Neoplasms
Promoter CpG methylation of multiple genes in pituitary adenomas: frequent involvement of caspase-8.
Pleural Effusion
Activation-induced cell death of memory CD8+ T cells from pleural effusion of lung cancer patients is mediated by the type II Fas-induced apoptotic pathway.
Pneumoconiosis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with risk of coal workers' pneumoconiosis.
Pneumoconiosis
Forecasting role of genetic markers in outlining features of pneumoconiosis course in post-contact period.
Pneumoconiosis
[Regulation role of superoxide dismutase coenzyme on Fas/FasL signal transduction and apoptosis in alveolar macrophages of pneonoconiosis patients]
Pneumoperitoneum
Room air versus carbon dioxide pneumoperitoneum: effects on oxidative state, apoptosis and histology of splanchnic organs.
Polycystic Kidney, Autosomal Dominant
Pathways of apoptosis in human autosomal recessive and autosomal dominant polycystic kidney diseases.
Polycystic Kidney, Autosomal Recessive
Pathways of apoptosis in human autosomal recessive and autosomal dominant polycystic kidney diseases.
Porcine Reproductive and Respiratory Syndrome
Yansuanmalingua inhibits replication of type 2 porcine reproductive and respiratory syndrome virus via activating the caspase-8 apoptosis pathway.
Pre-Eclampsia
Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis.
Pre-Eclampsia
CASPASE-8 gene polymorphisms (rs13416436 and rs2037815) are not associated with preeclampsia development in Brazilian women.
Pre-Eclampsia
Effect of maternal omega-3 fatty acids and vitamin E supplementation on placental apoptotic markers in rat model of early and late onset preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Aberrant promoter hypermethylation of selected apoptotic genes in childhood acute lymphoblastic leukemia among North Indian population.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
CD40L and IL-4 stimulation of acute lymphoblastic leukemia cells results in upregulation of mRNA level of FLICE--an important component of apoptosis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Functional polymorphisms in FAS, FASL and CASP8 genes and risk of childhood acute lymphoblastic leukemia: a case-control study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hypermethylation of two CpG sites upstream of CASP8AP2 promoter influences gene expression and treatment outcome in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Involvement of caspase-8 in chemotherapy-induced apoptosis of patient derived leukemia cell lines independent of the death receptor pathway and downstream from mitochondria.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Low mRNA expression of the apoptosis-related genes CASP3, CASP8, and FAS is associated with low induction treatment response in childhood acute lymphoblastic leukemia (ALL).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Searching in mother nature for anti-cancer activity: anti-proliferative and pro-apoptotic effect elicited by green barley on leukemia/lymphoma cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Clinical Significance of CASP8AP2 Gene Methylation in Childhood Acute Lymphoblastic Leukemia].
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Articulatin-D induces apoptosis via activation of caspase-8 in acute T-cell leukemia cell line.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Important role of caspase-8 for chemosensitivity of ALL cells.
Prostatic Neoplasms
2'-Hydroxy-4-methylsulfonylchalcone enhances TRAIL-induced apoptosis in prostate cancer cells.
Prostatic Neoplasms
A novel dietary triterpene Lupeol induces fas-mediated apoptotic death of androgen-sensitive prostate cancer cells and inhibits tumor growth in a xenograft model.
Prostatic Neoplasms
A six-nucleotide deletion in the CASP8 promoter is not associated with a susceptibility to breast and prostate cancers in the Polish population.
Prostatic Neoplasms
Apoptosis gene polymorphisms and risk of prostate cancer: A hospital-based study of German patients treated with brachytherapy.
Prostatic Neoplasms
Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer.
Prostatic Neoplasms
CASP8 promoter polymorphism, mRNA expression and risk of prostate cancer among Chinese men.
Prostatic Neoplasms
Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer.
Prostatic Neoplasms
Cryptocaryone, a Natural Dihydrochalcone, Induces Apoptosis in Human Androgen Independent Prostate Cancer Cells by Death Receptor Clustering in Lipid Raft and Nonraft Compartments.
Prostatic Neoplasms
Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation.
Prostatic Neoplasms
Differential Sensitization of Different Prostate Cancer Cells to Apoptosis.
Prostatic Neoplasms
Discovery of CASP8 as a potential biomarker for high-risk prostate cancer through a high-multiplex immunoassay.
Prostatic Neoplasms
Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway.
Prostatic Neoplasms
Elevation of c-FLIP in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy.
Prostatic Neoplasms
Glycogen synthase kinase-3beta suppression eliminates tumor necrosis factor-related apoptosis-inducing ligand resistance in prostate cancer.
Prostatic Neoplasms
hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways.
Prostatic Neoplasms
Impact of caspase-8 (CASP8) -652 6N del and D302H polymorphisms on prostate cancer in different ethnic groups.
Prostatic Neoplasms
Induction of apoptosis in hormone-resistant human prostate cancer PC3 cells by inactivated Sendai virus.
Prostatic Neoplasms
Influence of caspases 8 and 9 gene promoter polymorphism on prostate cancer susceptibility and early development of hormone refractory prostate cancer.
Prostatic Neoplasms
Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway.
Prostatic Neoplasms
Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer.
Prostatic Neoplasms
Insulin-like growth factor-binding protein-3 suppresses tumor growth via activation of caspase-dependent apoptosis and cross-talk with NF-?B signaling.
Prostatic Neoplasms
JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells.
Prostatic Neoplasms
miR-130a activates apoptotic signaling through activation of caspase-8 in taxane-resistant prostate cancer cells.
Prostatic Neoplasms
Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-?B activation.
Prostatic Neoplasms
Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy.
Prostatic Neoplasms
Proteasome inhibition blocks caspase-8 degradation and sensitizes prostate cancer cells to death receptor-mediated apoptosis.
Prostatic Neoplasms
Recurrence-free survival in prostate cancer is related to increased stromal TRAIL expression.
Prostatic Neoplasms
Sensitivity of prostate cells to TRAIL-induced apoptosis increases with tumor progression: DR5 and caspase 8 are key players.
Prostatic Neoplasms
Stromal anti-apoptotic androgen receptor target gene c-FLIP in prostate cancer.
Prostatic Neoplasms
Sulindac sulfide-induced apoptosis involves death receptor 5 and the caspase 8-dependent pathway in human colon and prostate cancer cells.
Prostatic Neoplasms
Targeting receptor for advanced glycation end products (RAGE) expression induces apoptosis and inhibits prostate tumor growth.
Prostatic Neoplasms
The andean anticancer herbal product BIRM causes destabilization of androgen receptor and induces caspase-8 mediated-apoptosis in prostate cancer.
Prostatic Neoplasms
The FAS-related apoptosis signaling pathway in the prostate intraepithelial neoplasia and cancer lesions.
Prostatic Neoplasms
TRAF2 is a Valuable Prognostic Biomarker in Patients with Prostate Cancer.
Protozoan Infections
Caspase-8 activity prevents type 2 cytokine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection.
Psoriasis
Association Study of the Caspase Gene Family and Psoriasis Vulgaris Susceptibility in Northeastern China.
Psoriasis
LncRNA MEG3 influences the proliferation and apoptosis of psoriasis epidermal cells by targeting miR-21/caspase-8.
Psoriasis
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL): a possible pathogenic role in chronic plaque psoriasis.
Pulmonary Disease, Chronic Obstructive
The role of bronchial epithelial cell apoptosis in the pathogenesis of COPD.
Pulmonary Edema
TNF-Induced Death Signaling Triggers Alveolar Epithelial Dysfunction in Acute Lung Injury.
Pulmonary Eosinophilia
Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis.
receptor protein serine/threonine kinase deficiency
Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-?B and MAPK signaling.
receptor protein serine/threonine kinase deficiency
Combination of IAP antagonist and IFN? activates novel caspase-10- and RIPK1-dependent cell death pathways.
receptor protein serine/threonine kinase deficiency
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.
Rectal Neoplasms
Clinicopathological significance of caspase-8 and caspase-10 expression in rectal cancer.
Rectal Neoplasms
Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathways.
Reoviridae Infections
Down-regulation of cFLIP following reovirus infection sensitizes human ovarian cancer cells to TRAIL-induced apoptosis.
Reoviridae Infections
Reovirus-induced apoptosis requires both death receptor- and mitochondrial-mediated caspase-dependent pathways of cell death.
Reperfusion Injury
Influence of Fat on Differential Receptor Interacting Serine/Threonine Protein Kinase 1 Activity Leading to Apoptotic Cell Death in Murine Liver Ischemia Reperfusion Injury Through Caspase 8.
Reperfusion Injury
Intracellular pH Regulates TRAIL-Induced Apoptosis and Necroptosis in Endothelial Cells.
Reperfusion Injury
Loss of RIPK3 and Caspase-8 Augments Intrinsic Apoptosis in Tubular Epithelial Cell and promote Kidney Ischemia Reperfusion Injury.
Reperfusion Injury
The cytoprotective effects of addition of activated protein C into preservation solution on small-for-size grafts in rats.
Retinal Detachment
FAS-mediated apoptosis and its relation to intrinsic pathway activation in an experimental model of retinal detachment.
Retinal Detachment
Inhibition of Retinal Detachment-induced Apoptosis in Photoreceptors by a Small Peptide Inhibitor of the Fas Receptor.
Retinal Diseases
Evidence For Multiple Cell Death Pathways During Development of Experimental Cytomegalovirus Retinitis in Mice with Retrovirus-induced Immunosuppression: Apoptosis, Necroptosis, and Pyroptosis.
Retinoblastoma
Human retinoblastoma cells are resistant to apoptosis induced by death receptors: role of caspase-8 gene silencing.
Retinoblastoma
One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma.
Retinoblastoma
RbAp48 is a critical mediator controlling the transforming activity of human papillomavirus type 16 in cervical cancer.
Rhabdomyosarcoma
Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma.
Rhabdomyosarcoma
Drozitumab, a human antibody to death receptor 5, has potent anti-tumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of response.
ribonuclease iii deficiency
DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.
RNA Virus Infections
A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis.
Salmonella Infections
CARD9 negatively regulates NLRP3-induced IL-1? production on Salmonella infection of macrophages.
Salmonella Infections
Characterization of Salmonella-induced cell death in human macrophage-like THP-1 cells.
Salmonella Infections
Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1? production.
Sarcoma
Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential.
Sarcoma 180
Involvement of Caspase 8 in Apoptosis Induced by Ultrasound-Activated Hematoporphyrin in Sarcoma 180 Cells In Vitro.
Sarcoma, Ewing
Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma.
Sarcoma, Ewing
Caspase-8 expression is predictive of tumour response to death receptor 5 agonist antibody in Ewing's sarcoma.
Sarcoma, Ewing
Characterization of distinct consecutive phases in non-genotoxic p53-induced apoptosis of Ewing tumor cells and the rate-limiting role of caspase 8.
Sarcoma, Ewing
Expression of cellular FLICE inhibitory protein, caspase-8, and protease inhibitor-9 in Ewing sarcoma and implications for susceptibility to cytotoxic pathways.
Sarcoma, Ewing
Histone deacetylase inhibitors induce cell death and enhance the apoptosis-inducing activity of TRAIL in Ewing's sarcoma cells.
Sarcoma, Ewing
Interferon-gamma sensitizes resistant Ewing's sarcoma cells to tumor necrosis factor apoptosis-inducing ligand-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivity.
Sarcoma, Ewing
Interferon-{gamma} Sensitizes Resistant Ewing's Sarcoma Cells to Tumor Necrosis Factor Apoptosis-Inducing Ligand-Induced Apoptosis by Up-Regulation of Caspase-8 Without Altering Chemosensitivity.
Sarcoma, Ewing
Proliferation index: a continuous model to predict prognosis in patients with tumours of the Ewing's sarcoma family.
Sarcoma, Ewing
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer.
Sarcoma, Kaposi
COX-2/PGE2: molecular ambassadors of Kaposi's sarcoma-associated herpes virus oncoprotein-v-FLIP.
Sarcoma, Kaposi
Deletion of Kaposi's sarcoma herpesvirus FLICE inhibitory protein (vFLIP) from the viral genome compromises the activation of STAT-1 responsive cellular genes and spindle cell formation in endothelial cells.
Sarcoma, Kaposi
Integrated microarray and multiplex cytokine analyses of Kaposi's Sarcoma Associated Herpesvirus viral FLICE Inhibitory Protein K13 affected genes and cytokines in human blood vascular endothelial cells.
Sarcoma, Kaposi
Kaposi's sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-kappaB pathway and functionally cooperates with Tat.
Sarcoma, Kaposi
Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-?B pathway independent of TRAF6, TAK1 and LUBAC.
Sarcoma, Kaposi
Kaposi's sarcoma associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice.
Sarcoma, Kaposi
Kaposi's sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 suppresses CXCR4 expression by upregulating miR-146a.
Sarcoma, Kaposi
NEMO is essential for KSHV-encoded vFLIP K13-induced gene expression and protection against death receptor-induced cell death and its N-terminal 251 residues are sufficient for this process.
Sarcopenia
Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats.
Scleroderma, Systemic
Anti-caspase-8 autoantibody response in silicosis patients is associated with HLA-DRB1, DQB1 and DPB1 alleles.
Scleroderma, Systemic
Autoantibody against a protease domain of caspase-8 in patients with systemic sclerosis.
Scoliosis
Expression of TRAIL and the death receptors DR4 and DR5 correlates with progression of degeneration in human intervertebral disks.
Seizures
Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons.
Seizures
Cleavage of bid may amplify caspase-8-induced neuronal death following focally evoked limbic seizures.
Seizures
Development of a model of seizure-induced hippocampal injury with features of programmed cell death in the BALB/c mouse.
Seizures
Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures.
Seizures
Inhibition of caspase-8 attenuates neuronal death induced by limbic seizures in a cytochrome c-dependent and Smac/DIABLO-independent way.
Seizures
Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat.
Sepsis
Administration of Human Protein-C concentrate prevents apoptotic brain cell death after experimental sepsis.
Sepsis
Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.
Sepsis
Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8.
Sepsis
Mechanisms underlying mouse TNF-? stimulated neutrophil derived microparticle generation.
Sepsis
Molecular mechanisms underlying delayed apoptosis in neutrophils from multiple trauma patients with and without sepsis.
Sepsis
P2X1, P2X4, and P2X7 Receptor Knock Out Mice Expose Differential Outcome of Sepsis Induced by ?-Haemolysin Producing Escherichia coli.
Sepsis
Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis.
Sepsis
The JNK MAP kinase pathway contributes to the development of endotoxin-induced diaphragm caspase activation.
Severe Acute Respiratory Syndrome
Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity.
Shock, Septic
Caspase-8 inhibition represses initial human monocyte activation in septic shock model.
Silicosis
Anti-caspase-8 autoantibody response in silicosis patients is associated with HLA-DRB1, DQB1 and DPB1 alleles.
Skin Diseases
Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease.
Skin Diseases
cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis.
Skin Diseases
Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8.
Skin Diseases
Sustained Secretion of the Antimicrobial Peptide S100A7 Is Dependent on the Downregulation of Caspase-8.
Skin Neoplasms
FLIP ing the coin? Death receptor-mediated signals during skin tumorigenesis.
Small Cell Lung Carcinoma
Doxorubicin and etoposide sensitize small cell lung carcinoma cells expressing caspase-8 to TRAIL.
Small Cell Lung Carcinoma
Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification.
Small Cell Lung Carcinoma
Retinoic acid induces caspase-8 transcription via phospho-CREB and increases apoptotic responses to death stimuli in neuroblastoma cells.
Small Cell Lung Carcinoma
Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation.
Small Cell Lung Carcinoma
TIMP-3 promotes apoptosis in nonadherent small cell lung carcinoma cells lacking functional death receptor pathway.
Spinal Cord Compression
Molecular mechanisms of spinal cord dysfunction and cell death in the spinal hyperostotic mouse: implications for the pathophysiology of human cervical spondylotic myelopathy.
Spinal Cord Injuries
Tumor Necrosis Factor-Alpha Antagonist Reduces Apoptosis of Neurons and Oligodendroglia in Rat Spinal Cord Injury.
Spinal Dysraphism
Apoptosis, Expression of PAX3 and P53, and Caspase Signal in Fetuses with Neural Tube Defects.
Squamous Cell Carcinoma of Head and Neck
Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact.
Squamous Cell Carcinoma of Head and Neck
Association of caspase-8 mutation with chemoresistance to cisplatin in HOC313 head and neck squamous cell carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
Cancer-associated missense mutations of caspase-8 activate nuclear factor-?B signaling.
Squamous Cell Carcinoma of Head and Neck
Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic-induced necroptosis.
Squamous Cell Carcinoma of Head and Neck
Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction.
Squamous Cell Carcinoma of Head and Neck
Caspase-8 polymorphisms and risk of oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.
Squamous Cell Carcinoma of Head and Neck
Differential mutation spectrum and immune landscape in African Americans versus Whites: A possible determinant to health disparity in head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer.
Squamous Cell Carcinoma of Head and Neck
GSTP1 c.313A>G, XPD c.934G>A, XPF c.2505T>C and CASP9 c.-1339A>G Polymorphisms and Severity of Vomiting in Head and Neck Cancer Patients treated with Cisplatin Chemoradiation.
Squamous Cell Carcinoma of Head and Neck
In silico analysis reveals a shared immune signature in CASP8-mutated carcinomas with varying correlations to prognosis.
Squamous Cell Carcinoma of Head and Neck
Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation.
Squamous Cell Carcinoma of Head and Neck
Loss of caspase-8 activation pathway is a possible mechanism for CDDP resistance in human laryngeal squamous cell carcinoma, HEp-2 cells.
Squamous Cell Carcinoma of Head and Neck
Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups.
Squamous Cell Carcinoma of Head and Neck
Prognostic impact of Fas-associated death domain, a key component in death receptor signaling, is dependent on the presence of lymph node metastasis in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Role of caspase 8 as a determinant in chemosensitivity of p53-mutated head and neck squamous cell carcinoma cell lines.
Squamous Cell Carcinoma of Head and Neck
The genomic landscape of UM-SCC oral cavity squamous cell carcinoma cell lines.
Squamous Cell Carcinoma of Head and Neck
The non-coding landscape of head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
The proteasome inhibitor MG132 potentiates TRAIL receptor agonist-induced apoptosis by stabilizing tBid and Bik in human head and neck squamous cell carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
[Expressions of receptor-interacting protein and caspase-8 in oral squamous cell carcinoma and oral precancerous lesions.]
Starvation
Amino Acid Deprivation Induces Both Apoptosis and Autophagy in Murine C2C12 Muscle Cells
Starvation
Amino acid deprivation induces both apoptosis and autophagy in murine C2C12 muscle cells.
Starvation
ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation.
Starvation
Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis.
Starvation
Exosomal secretion of truncated cytosolic lysyl-tRNA synthetase induces inflammation during cell starvation.
Starvation
Formation of noncanonical high molecular weight caspase-3 and -6 complexes and activation of caspase-12 during serum starvation induced apoptosis in AKR-2B mouse fibroblasts.
Starvation
Plasmalogens rescue neuronal cell death through an activation of AKT and ERK survival signaling.
Starvation
Single cell dielectrophoresis study of apoptosis progression induced by controlled starvation.
Starvation
Suppressed translation as a mechanism of initiation of CASP8 (caspase 8)-dependent apoptosis in autophagy-deficient NSCLC cells under nutrient limitation.
Status Epilepticus
Caspase-dependent programmed cell death pathways are not activated in generalized seizure-induced neuronal death.
Stomach Neoplasms
A six-nucleotide deletion polymorphism in the casp8 promoter is associated with reduced risk of esophageal and gastric cancers in Kashmir valley.
Stomach Neoplasms
Anti-tumor mechanism of IL-21 used alone and in combination with 5-fluorouracil in vitro on human gastric cancer cells.
Stomach Neoplasms
Caspase 8 and caspase 9 gene polymorphisms and susceptibility to gastric cancer.
Stomach Neoplasms
CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas.
Stomach Neoplasms
Caspase-8 is scarcely silenced and its activity is well correlated with the anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand in gastric cancer cells.
Stomach Neoplasms
Detecting promoter methylation pattern of apoptotic genes Apaf1 and Caspase8 in gastric carcinoma patients undergoing chemotherapy.
Stomach Neoplasms
Deubiquitinylase USP47 Promotes RelA Phosphorylation and Survival in Gastric Cancer Cells.
Stomach Neoplasms
DR5-Cbl-b/c-Cbl-TRAF2 complex inhibits TRAIL-induced apoptosis by promoting TRAF2-mediated polyubiquitination of caspase-8 in gastric cancer cells.
Stomach Neoplasms
Functional polymorphisms in apoptosis pathway genes and survival in patients with gastric cancer.
Stomach Neoplasms
IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells.
Stomach Neoplasms
Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer.
Stomach Neoplasms
miR-106a Is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS.
Stomach Neoplasms
miR-200a enhances TRAIL-induced apoptosis in gastric cancer cells by targeting A20.
Stomach Neoplasms
Reovirus infection induces apoptosis of TRAIL-resistant gastric cancer cells by down-regulation of Akt activation.
Stomach Neoplasms
Roles of Fas signaling pathway in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells.
Stomach Neoplasms
SLPI promotes the gastric cancer growth and metastasis by regulating the expression of P53, Bcl-2 and Caspase-8.
Stomach Neoplasms
The extrinsic apoptotic signaling pathway in gastric adenocarcinomas assessed by tissue microarray.
Stomach Neoplasms
Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer.
Stomach Neoplasms
[Effect of Paridis Rhizoma total saponins on apoptosis of human gastric cancer cell MKN-45 and Fas/FasL signaling pathway].
Stomach Neoplasms
[Inducement of FLICE inhibitory protein antisense oligonucleotides on apoptosis of human gastric cancer cell line BGC823]
Stomatitis
Lentivirus-Based Virus-Like Particles Mediate Delivery of Caspase 8 into Breast Cancer Cells and Inhibit Tumor Growth.
Stroke
Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat.
Stroke
Superoxide during reperfusion contributes to caspase-8 expression and apoptosis after transient focal stroke.
Subarachnoid Hemorrhage
Corrigendum: Target inhibition of caspase-8 alleviates brain damage after subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Target inhibition of caspase-8 alleviates brain damage after subarachnoid hemorrhage.
Tendinopathy
Relationship of common variants in MPP7, TIMP2 and CASP8 genes with the risk of chronic achilles tendinopathy.
Tendinopathy
The Apoptosis Pathway and CASP8 Variants Conferring Risk for Acute and Overuse Musculoskeletal Injuries.
Thrombocythemia, Essential
Effects of polymorphic DNA genes involved in BER and caspase pathways on the clinical outcome of myeloproliferative neoplasms under treatment with hydroxyurea.
Thymoma
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Thyroid Cancer, Papillary
Fas signaling in thyroid carcinomas is diverted from apoptosis to proliferation.
Thyroid Cancer, Papillary
Role of Caspase 8, Caspase 9 and Bcl-2 polymorphisms in papillary thyroid carcinoma risk in Han Chinese population.
Thyroid Carcinoma, Anaplastic
Cytochrome c release is upstream to activation of caspase-9, caspase-8, and caspase-3 in the enhanced apoptosis of anaplastic thyroid cancer cells induced by manumycin and paclitaxel.
Thyroid Diseases
Identification of apoptotic proteins in thyroid gland from patients with Graves' disease and Hashimoto's thyroiditis.
Thyroid Diseases
[Analysis of Fas, FasL and Caspase-8 expression in thyroid gland in young patients with immune and non-immune thyroid diseases]
Thyroid Neoplasms
Autocrine production of interleukin-4 and interleukin-10 is required for survival and growth of thyroid cancer cells.
Thyroid Neoplasms
Fas signaling in thyroid carcinomas is diverted from apoptosis to proliferation.
Thyroid Neoplasms
Regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by DJ-1 in thyroid cancer cells.
Thyroiditis
[Analysis of Fas, FasL and Caspase-8 expression in thyroid gland in young patients with immune and non-immune thyroid diseases]
Tongue Neoplasms
All HPV-negative head and neck cancers are not the same: Analysis of the TCGA dataset reveals that anatomical sites have distinct mutation, transcriptome, hypoxia, and tumor microenvironment profiles.
Tongue Neoplasms
Rhein Induced Apoptosis through the Endoplasmic Reticulum Stress, Caspase- and Mitochondria-dependent Pathways in SCC-4 Human Tongue Squamous Cancer Cells.
Toxoplasmosis
Potential Molecular Mechanisms of Plantain in the Treatment of Gout and Hyperuricemia Based on Network Pharmacology.
Tremor
Cerebellar Upregulation of Cell Surface Death Receptor-Mediated Apoptotic Factors in Harmaline-Induced Tremor: An Immunohistochemistry Study.
Trench Fever
In vitro Bartonella quintana infection modulates the programmed cell death and inflammatory reaction of endothelial cells.
Tricuspid Valve Insufficiency
Mitochondrial apoptotic pathway activation in the atria of heart failure patients due to mitral and tricuspid regurgitation.
Triple Negative Breast Neoplasms
Lifeguard inhibition of Fas-mediated apoptosis: A possible mechanism for explaining the cisplatin resistance of triple-negative breast cancer cells.
Triple Negative Breast Neoplasms
PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1.
Triple Negative Breast Neoplasms
Unusual roles of caspase-8 in triple-negative breast cancer cell line MDA-MB-231.
Truncus Arteriosus, Persistent
Type 2 diabetes mellitus induces congenital heart defects in murine embryos by increasing oxidative stress, endoplasmic reticulum stress and apoptosis.
Tuberculosis
Caspase 1 and caspase 8 in HIV infected patients with and without tuberculosis.
Tuberculosis
Expression of TNF-alpha-dependent apoptosis-related genes in the peripheral blood of Malagasy subjects with tuberculosis.
Tuberculosis
Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNF?, NF?B, p38 and caspase 8 dependent pathways.
Tuberculosis
Stable extracellular RNA fragments of Mycobacterium tuberculosis induce early apoptosis in human monocytes via a caspase-8 dependent mechanism.
Ureteral Obstruction
Turmeric-based diet can delay apoptosis without modulating NF-kappaB in unilateral ureteral obstruction in rats.
Urinary Bladder Neoplasms
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter associated with risk and progression of bladder cancer.
Urinary Bladder Neoplasms
Caspase 9 and Caspase 8 Gene Polymorphisms and Susceptibility to Bladder Cancer in North Indian Population.
Urinary Bladder Neoplasms
Pseudomonas aeruginosa-mannose-sensitive hemagglutinin inhibits proliferation and induces apoptosis in a caspase-dependent manner in human bladder cancer cell lines.
Uterine Cervical Neoplasms
Aberrant DNA methylation of apoptotic signaling genes in patients responsive and nonresponsive to therapy for cervical carcinoma.
Uterine Cervical Neoplasms
Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation.
Uterine Cervical Neoplasms
Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and Brachytherapy.
Uterine Cervical Neoplasms
CASP8 promoter polymorphism is associated with high-risk HPV types and abnormal cytology but not with cervical cancer.
Uterine Cervical Neoplasms
Celecoxib induces apoptosis in cervical cancer cells independent of cyclooxygenase using NF-kappaB as a possible target.
Uterine Cervical Neoplasms
CpG Island Methylation of TMS1/ASC and CASP8 Genes in Cervical Cancer.
Uterine Cervical Neoplasms
Flavonol and imidazole derivatives block HPV16 E6 activities and reactivate apoptotic pathways in HPV(+) cells.
Uterine Cervical Neoplasms
Genetic Susceptibility for Cervical Cancer in African Populations: What Are the Host Genetic Drivers?
Uterine Cervical Neoplasms
Integrated genomic and molecular characterization of cervical cancer.
Uterine Cervical Neoplasms
Sensitivity to Fas-mediated apoptosis in high-risk HPV-positive human cervical cancer cells: relationship with Fas, caspase-8, and Bid.
Uterine Cervical Neoplasms
Synergistic anticancer activity of dietary tea polyphenols and bleomycin hydrochloride in human cervical cancer cell: Caspase-dependent and independent apoptotic pathways.
Uterine Cervical Neoplasms
The apoptotic effect of intercalating agents on HPV-negative cervical cancer C-33A cells.
Uterine Cervical Neoplasms
The apoptotic effects of the flavonoid N101-2 in human cervical cancer cells.
Uterine Cervical Neoplasms
The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling.
Uterine Cervical Neoplasms
The combined risks of reduced or increased function variants in cell death pathway genes differentially influence cervical cancer risk and herpes simplex virus type 2 infection among black Africans and the Mixed Ancestry population of South Africa.
Uterine Cervical Neoplasms
Triggering of death receptor apoptotic signaling by human papillomavirus 16 E2 protein in cervical cancer cell lines is mediated by interaction with c-FLIP.
Uterine Cervical Neoplasms
[Pro-apoptotic efficiencies of three reconstructed human caspase-8 on cervical cancer cell line HeLa]
Varicocele
Dysregulated apoptosis through the intrinsic pathway in the internal spermatic vein of patients with varicocele.
Varicose Veins
Association of primary varicose veins with dysregulated vein wall apoptosis.
Vascular Diseases
Endothelial cell apoptosis is induced by fetal plasma from pregnancy with umbilical placental vascular disease.
Virus Diseases
A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation.
Virus Diseases
Apoptosis Induction by dsRNA-Dependent Protein Kinase R (PKR) in EPC Cells via Caspase 8 and 9 Pathways.
Virus Diseases
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity.
Virus Diseases
Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection.
Virus Diseases
Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner.
Virus Diseases
Myxoma Virus Induces Ligand Independent Extrinsic Apoptosis in Human Myeloma Cells.
Virus Diseases
Porcine Epidemic Diarrhea Virus Infection Induces Caspase-8 mediated G3BP1 Cleavage and Subverts Stress Granules to Promote Viral Replication.
Virus Diseases
Remarkably Robust Antiviral Immune Response despite Combined Deficiency in Caspase-8 and RIPK3.
Virus Diseases
RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein.
Virus Diseases
Sendai virus infection induces apoptosis through activation of caspase-8 (FLICE) and caspase-3 (CPP32).
Virus Diseases
The first tropical sea cucumber caspase-8 from Holothuria leucospilota: Molecular characterization, involvement of apoptosis and inducible expression by immune challenge.
Virus Diseases
Tioman virus infection in experimentally infected mouse brain and its association with apoptosis.
Virus Diseases
[Antagonism of baicalin on cell cyclical distribution and cell apoptosis in A549 cells infected with influenza A (H1N1) virus].
Whooping Cough
Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways.
Wilms Tumor
Multigene methylation analysis of Wilms' tumour and adult renal cell carcinoma.
Wilms Tumor
SLIT2 promoter methylation analysis in neuroblastoma, Wilms' tumour and renal cell carcinoma.
Yersinia Infections
Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death.
Yersinia Infections
Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection.
Zika Virus Infection
Zika virus infection induced apoptosis by modulating the recruitment and activation of pro-apoptotic protein Bax.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0206
acetyl-IETD-7-amido-4-fluoromethylcoumarin
cleaved caspase-8, 37°C, pH 7.4, in the presence of 0.7 M sodium citrate
0.0293
acetyl-IETD-7-amido-4-fluoromethylcoumarin
non-cleavable caspase-8 + 0.001 mM FLIP D297A, 37°C, pH 7.4, in the presence of 0.7 M sodium citrate
0.0313
acetyl-IETD-7-amido-4-fluoromethylcoumarin
non-cleavable caspase-8 + 0.001 mM FLIP, 37°C, pH 7.4, in the presence of 0.7 M sodium citrate
0.0552
acetyl-IETD-7-amido-4-fluoromethylcoumarin
cleaved caspase-8, 37°C, pH 7.4
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.65
acetyl-IETD-7-amido-4-fluoromethylcoumarin
cleaved caspase-8, 37°C, pH 7.4
0.78
acetyl-IETD-7-amido-4-fluoromethylcoumarin
non-cleavable caspase-8 + 0.001 mM FLIP D297A, 37°C, pH 7.4, in the presence of 0.7 M sodium citrate
0.98
acetyl-IETD-7-amido-4-fluoromethylcoumarin
non-cleavable caspase-8 + 0.001 mM FLIP, 37°C, pH 7.4, in the presence of 0.7 M sodium citrate
1.25
acetyl-IETD-7-amido-4-fluoromethylcoumarin
cleaved caspase-8, 37°C, pH 7.4, in the presence of 0.7 M sodium citrate
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
the levels of caspase-3 and caspase-8 in plasma are both significantly higher than in sperm
brenda
OCUM-2M, OCUM-1, OCUM-8, OCUM-9, NUGC3, NIGC4, MKN45, MKN74, FU97, MKN7
brenda
MCF7 A/Z breast adenocarcinoma cell defective for nuclear factor kappa-B activation
brenda
caspase-8L is generated by the alternative splicing of human caspase-8
brenda
increase in caspase-8 transcript levels and activity after irradiation
brenda
increase in caspase-8 transcript levels and activity after irradiation
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
model of caspase 8 activation. Upon apoptosis induction triggered by interaction of the death ligand to the trimeric death receptor, adaptor FADD (Fas-associated protein with death domain ) is recruited to the death receptor via a death domain DD-DD interaction. FADD recruited at cell surface can recruit caspase-8 via a DED-DED interaction, leading to procaspase-8 proximity to meet another procaspase-8. Closely located FL motif on DED2 causes domain swapping and dimerization of procaspase-8. The dimerization via tandem DED domain swapping causes the proximity-mediated self-activation of caspase-8
physiological function
malfunction
caspase 8 knockdown stabilizes both cellular inhibitor of apoptosis 1, cIAP-1, and X-linked IAP, XIAP
malfunction
caspase-8 is coupled with the regulation of various neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease and dentatorubral pallidoluysian atrophy
physiological function
Tumor necrosis factorrelated apoptosis-inducing ligand, TRAIL, induces degradation of cellular inhibitor of apoptosis 1, cIAP-1, requiring caspase 8 activity, for, at least in part, direct cleavage of cIAP-1 by caspase 8. Cellular depletion of cIAP-1 enhances the efficiency of TRAIL-mediated apoptosis. cIAP-1 and cIAP-2 are responsible for Lys-63 polyubiquitination of RIP1 in cancer cells, which, in turn, results in activation of NF-kappaBmediated survival signals
physiological function
cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death
physiological function
the enzyme is a key mediator of neuronal apoptosis
physiological function
caspase-10 negatively regulates caspase-8-mediated cell death. Caspase-10 reduces death-inducing signaling complex DISC association and activation of caspase-8. Caspase-10 does not compete with caspase-8 for binding to adaptor protein FADD. Caspase-8 is required upstream of both regulator cFLIP and caspase-10 and DISC formation critically depends on the scaffold function of caspase-8. Caspase-10 rewires DISC signaling to NF-kappaB activation/cell survival and the catalytic activity of caspase-10, and caspase-8, is redundant in gene induction
physiological function
cleavage by caspase 8 and the subsequent association with the outer mitochondrial membrane are two critical events that activate BH3-only protein Bid during death receptor-mediated apoptosis
physiological function
infection by Trypanosoma cruzi induces caspase-8 activity and caspase-8 inhibition increases trophoblast cells infection while decreases parasite-induced cellular differentiation and apoptotic cell death, but not cellular proliferation
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). CASP8_HUMAN
479
0
55391
Swiss-Prot
other Location (Reliability: 1)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
18000
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
dimer
monomer
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of a complex of the activated caspase-8 proteolytic domain with the irreversible peptidic inhibitor benzyloxycarbonyl-EVD-dichloromethylketone, vapour diffusion method
crystallization of the enzyme covalently modified with acetyl-IETD-aldehyde, hanging- and sitting-drop vapor diffusion
structure of caspase-8 tandem death effector domains (DEDs), reveals domain-swapped dimerization. DEDs exist as dimers in solution. The FL motif on DED2 is critical for caspase-8 dimerization via domain swapping
structure of the N-terminal tandem death effector domains, DEDs and comparison with caspase 8 of Molluscum contagiosum virus subtype 1
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
D210A/D216A
cannot be cleaved to release death effector domains, overexpression inhibits the endothelial cell leukocyte adhesion molecule 1 promoter activation induced by Fas-associated death domain and receptor-interacting protein 1
F122A/I128D
mutations in the N-terminal tandem death effector domains. Mutations markedly reduce the aggregation and improve the solubility
additional information
additional information
short hairpin RNA knockdown of cIAP-1, cIAP-2, XIAP, and caspase 8 using a lentiviral vector in HuH-7 cells
additional information
-
short hairpin RNA knockdown of cIAP-1, cIAP-2, XIAP, and caspase 8 using a lentiviral vector in HuH-7 cells
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
tumor necrosis factorrelated apoptosis-inducing ligand, TRAIL, signaling induces caspase 8
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
drug development
gastric cancer might be a good target of TRAIL therapy because the majority of tumor cells have intact caspase-8 expression. The anticancer efficacy may be predicted by the degree of caspase-8 activation after TRAIL treatment
medicine
medicine
caspase-8 activation mediates p53-independent apoptosis of glioma cells
medicine
caspase-8 mediates NF-kappa-B-dependent inflammatory responses in antiviral signaling
medicine
caspase-8 plays an important role in Pseudomonas aeruginosa Exotoxin A-induced mast cell apoptosis
medicine
HER-2 cleavage contributes to the TNF-alpha-induced apoptosis pathway
medicine
compound 6'-benzyloxy-4-bromo-2'-hydroxychalcone displays potent cytotoxic properties against human leukaemia cells U-937, HL-60, K-562, NALM-6 and MOLT-3. Application results in significant activation of caspase-8 after 24 h of treatment
medicine
infection by Trypanosoma cruzi induces caspase-8 activity and caspase-8 inhibition increases trophoblast cells infection while decreases parasite-induced cellular differentiation and apoptotic cell death, but not cellular proliferation
medicine
levels of caspase-8 and caspase-9 in sperm and plasma are significantly negatively correlated with sperm concentration, motility and A % (motility grade A). The level of caspase-8 in plasma is significantly negatively correlated with sperm concentration. Compared with the healthy fertile controls, only the oligoasxadthenoteratozoospermia group exhibited significantly increased level of caspase-8 in sperm
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boldin, M.P.; Goncharov, T.M.; Goltsev, Y.V.; Wallach, D.
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
Cell
85
803-815
1996
Homo sapiens (Q14790)
brenda
Fernandes-Alnemri, T.; Armstrong, R.C.; Krebs, J.F.; Srinivasula, S.M.; Wang, L.; Bullrich, F.; Fritz, L.C.; Trapani, J.A.; Tomaselli, K.J.; Litwack, G.; Alnemri, E.S.
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
Proc. Natl. Acad. Sci. USA
93
7464-7469
1996
Homo sapiens (Q14790), Homo sapiens
brenda
Himeji, D.; Horiuchi, T.; Tsukamoto, H.; Hayashi, K.; Watanabe, T.; Harada, M.
Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade
Blood
99
4070-4078
2002
Homo sapiens (Q14790), Homo sapiens
brenda
Muzio, M.; Salvesen, G.S.; Dixit, V.M.
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens
J. Biol. Chem.
272
2952-2956
1997
Homo sapiens (Q14790)
brenda
Ng, F.W.H.; Nguyen, M.; Kwan, T.; Branton, P.E.; Nicholson, D.W.; Cromlish, J.A.; Shore, G.C.
p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum
J. Cell Biol.
139
327-338
1997
Homo sapiens (Q14790), Homo sapiens
brenda
Blanchard, H.; Kodandapani, L.; Mittl, P.R.E.; Di Marco, S.; Krebs, J.F.; Wu, J.C.; Tomaselli, K.J.; Gruetter, M.G.
The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis
Structure
7
1125-1133
1999
Homo sapiens (Q14790), Homo sapiens
brenda
Blanchard, H.; Donepudi, M.; Tschopp, M.; Kodandapani, L.; Wu, J.C.; Grutter, M.G.
Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-CHO complex
J. Mol. Biol.
302
9-16
2000
Homo sapiens (Q14790)
brenda
Watt, W.; Koeplinger, K.A.; Mildner, A.M.; Heinrikson, R.L.; Tomasselli, A.G.; Watenpaugh, K.D.
The atomic-resolution structure of human caspase-8, a key activator of apoptosis
Structure Fold. Des.
7
1135-1143
1999
Homo sapiens (Q14790), Homo sapiens
brenda
Breckenridge, D.G.; Nguyen, M.; Kuppig, S.; Reth, M.; Shore, G.C.
The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum
Proc. Natl. Acad. Sci. USA
99
4331-4336
2002
Homo sapiens (Q14790)
brenda
Boatright, K.M.; Deis, C.; Denault, J.B.; Sutherlin, D.P.; Salvesen, G.S.
Activiation of caspases-8 and -10 by FLIP L
Biochem. J.
382
651-657
2004
Homo sapiens (Q14790)
brenda
Benoit, V.; Chariot, A.; Delacroix, L.; Deregowski, V.; Jacobs, N.; Merville, M.P.; Bours, V.
Caspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappaB through c-FLIP-L expression
Cancer Res.
64
2684-2691
2004
Homo sapiens (Q14790), Homo sapiens
brenda
Afshar, G.; Jelluma, N.; Yang, X.; Basila, D.; Arvold, N.D.; Karlsson, A.; Yount, G.L.; Dansen, T.B.; Koller, E.; Haas-Kogan, D.A.
Radiation-induced caspase-8 mediates p53-independent apoptosis in glioma cells
Cancer Res.
66
4223-4232
2006
Homo sapiens (Q14790)
brenda
Bidere, N.; Snow, A.L.; Sakai, K.; Zheng, L.; Lenardo, M.J.
Caspase-8 Regulation by Direct Interaction with TRAF6 in T Cell Receptor-Induced NF-kappaB Activation
Curr. Biol.
16
1666-1671
2006
Homo sapiens (Q14790)
brenda
Su, C.L.; Huang, L.L.; Huang, L.M.; Lee, J.C.; Lin, C.N.; Won, S.J.
Caspase-8 acts as a key upstream executor of mitochondria during justicidin A-induced apoptosis in human hepatoma cells
FEBS Lett.
580
3185-3191
2006
Homo sapiens (Q14790), Homo sapiens
brenda
Jenkins, C.E.; Swiatoniowski, A.; Issekutz, A.C.; Lin, T.J.
Pseudomonas aeruginosa exotoxin A induces human mast cell apoptosis by a caspase-8 and -3-dependent mechanism
J. Biol. Chem.
279
37201-37207
2004
Homo sapiens (Q14790), Homo sapiens
brenda
Liedtke, C.; Groeger, N.; Manns, M.P.; Trautwein, C.
Interferon-alpha enhances TRAIL-mediated apoptosis by up-regulating caspase-8 transcription in human hepatoma cells
J. Hepatol.
44
342-349
2006
Homo sapiens (Q14790), Homo sapiens
brenda
Takahashi, K.; Kawai, T.; Kumar, H.; Sato, S.; Yonehara, S.; Akira, S.
Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA
J. Immunol.
176
4520-4524
2006
Homo sapiens (Q14790), Homo sapiens
brenda
Fischer, U.; Stroh, C.; Schulze-Osthoff, K.
Unique and overlapping substrate specificities of caspase-8 and caspase-10
Oncogene
25
152-159
2006
Homo sapiens (Q14790)
brenda
Kanehara, I.; Nakata, B.; Hirakawa, K.
Caspase-8 is scarcely silenced and its activity is well correlated with the anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand in gastric cancer cells
Oncol. Rep.
14
1249-1253
2005
Homo sapiens (Q14790)
brenda
Bidle, K.A.; Haramaty, L.; Baggett, N.; Nannen, J.; Bidle, K.D.
Tantalizing evidence for caspase-like protein expression and activity in the cellular stress response of Archaea
Environ. Microbiol.
12
1161-1172
2010
Homo sapiens (Q14790), Homo sapiens
brenda
Guicciardi, M.E.; Mott, J.L.; Bronk, S.F.; Kurita, S.; Fingas, C.D.; Gores, G.J.
Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis
Exp. Cell Res.
317
107-116
2011
Homo sapiens (Q14790), Homo sapiens
brenda
Oral, O.; Oz-Arslan, D.; Itah, Z.; Naghavi, A.; Deveci, R.; Karacali, S.; Gozuacik, D.
Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death
Apoptosis
17
810-820
2012
Homo sapiens (Q14790)
brenda
Ahmad, K.; Khan, S.; Adil, M.; Saeed, M.; Srivastava, A.K.
Structure based molecular inhibition of Caspase-8 for treatment of multi-neurodegenerative diseases using known natural compounds
Bioinformation
10
191-195
2014
Homo sapiens (Q14790)
brenda
Shen, C.; Yue, H.; Pei, J.; Guo, X.; Wang, T.; Quan, J.M.
Crystal structure of the death effector domains of caspase-8
Biochem. Biophys. Res. Commun.
463
297-302
2015
Homo sapiens (Q14790)
brenda
Park, H.H.
Molecular basis of dimerization of initiator caspase was revealed by crystal structure of caspase-8 pro-domain
Cell Death Differ.
26
1213-1220
2019
Homo sapiens (Q14790)
brenda
Horn, S.; Hughes, M.A.; Schilling, R.; Sticht, C.; Tenev, T.; Ploesser, M.; Meier, P.; Sprick, M.R.; MacFarlane, M.; Leverkus, M.
Caspase-10 negatively regulates caspase-8-mediated cell death, switching the response to CD95L in favor of NF-kappaB activation and cell survival
Cell Rep.
19
785-797
2017
Homo sapiens (Q14790)
brenda
Saavedra, E.; Del Rosario, H.; Brouard, I.; Quintana, J.; Estevez, F.
6-Benzyloxy-4-bromo-2-hydroxychalcone is cytotoxic against human leukaemia cells and induces caspase-8- and reactive oxygen species-dependent apoptosis
Chem. Biol. Interact.
298
137-145
2019
Homo sapiens (Q14790)
brenda
Carrillo, I.; Droguett, D.; Castillo, C.; Liempi, A.; Munoz, L.; Maya, J.D.; Galanti, N.; Kemmerling, U.
Caspase-8 activity is part of the BeWo trophoblast cell defense mechanisms against Trypanosoma cruzi infection
Exp. Parasitol.
168
9-15
2016
Homo sapiens (Q14790)
brenda
Wei, X.; Li, Q.; Han, Z.; Lin, D.; Yu, P.
Differences in caspase-8 and -9 activity and sperm motility in infertile males of Li nationality in China
Int. J. Clin. Exp. Med.
8
4721-4726
2015
Homo sapiens (Q14790), Homo sapiens
brenda
Huang, K.; Zhang, J.; ONeill, K.L.; Gurumurthy, C.B.; Quadros, R.M.; Tu, Y.; Luo, X.
Cleavage by caspase 8 and mitochondrial membrane association activate the BH3-only protein Bid during TRAIL-induced apoptosis
J. Biol. Chem.
291
11843-11851
2016
Homo sapiens (Q14790)
brenda
EXTERNAL LINKS (specific for EC-Number 3.4.22.61)
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