Reference on EC 3.4.22.60 - caspase-7
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Strausberg R.L.; Feingold E.A.; Grouse L.H.; Derge J.G.; et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Proc. Natl. Acad. Sci. USA
99
16899-16903
2002
Homo sapiens (P55210), Mus musculus (P97864)
Nakajima, K.; Takahashi, A.; Yaoita, Y.
Structure, expression, and function of the Xenopus laevis caspase family
J. Biol. Chem.
275
10484-10491
2000
Xenopus laevis
Garcia-Calvo, M.; Peterson, E.P.; Leiting, B.; Ruel, R.; Nicholson, D.W.; Thornberry, N.A.
Inhibition of human caspases by peptide-based and macromolecular inhibitors
J. Biol. Chem.
273
32608-32613
1998
Homo sapiens
Garcia-Calvo, M.; Peterson, E.P.; Rasper, D.M.; Vaillancourt, J.P.; Zamboni, R.; Nicholson, D.W.; Thornberry, N.A.
Purification and catalytic properties of human caspase family members
Cell Death Differ.
6
362-369
1999
Homo sapiens
Chang, H.Y.; Yang, X.
Proteases from cell suicide: functions and regulation of caspases
Microbiol. Mol. Biol. Rev.
64
821-846
2000
Homo sapiens
Thornberry, N.A.; Rano, T.A.; Peterson, E.P.; et al.
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
J. Biol. Chem.
272
17907-17911
1997
Homo sapiens
Fernandes-Alnemri, T.; Armstrong, R.C.; Krebs, J.F.; Srinivasula, S.M.; Wang, L.; Bullrich, F.; Fritz, L.C.; Trapani, J.A.; Tomaselli, K.J.; Litwack, G.; Alnemri, E.S.
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
Proc. Natl. Acad. Sci. USA
93
7464-7469
1996
Homo sapiens (P55210)
van de Craen, M.; Vandenabeele, P.; Declercq, W.; van den Brande, I.; van Loo, G.; Molemans, F.; Schotte, P.; van Criekinge, W.; Beyaert, R.; Fiers, W.
Characterization of seven murine caspase family members
FEBS Lett.
403
61-69
1997
Mus musculus (P97864)
Eleouet, J.F.; Slee, E.A.; Saurini, F.; Castagne, N.; Poncet, D.; Garrido, C.; Solary, E.; Martin, S.J.
The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and -7 during TGEV-induced apoptosis
J. Virol.
74
3975-3983
2000
Homo sapiens
Talanian, R.V.; Quinlan, C.; Trautz, S.; Hackett, M.C.; Mankovich, J.A.; Banach, D.; Ghayur, T.; Brady, K.D.; Wong, W.W.
Substrate specificities of caspase family proteases
J. Biol. Chem.
272
9677-9682
1997
Homo sapiens
Margolin, N.; Raybuck, S.A.; Wilson, K.P.; Chen, W.; Fox, T.; Gu, Y.; Livingston, D.J.
Substrate and inhibitor specificity of interleukin-1beta-converting enzyme and related caspases
J. Biol. Chem.
272
7223-7228
1997
Homo sapiens
Bae, S.S.; Choi, J.H.; Oh, Y.S.; Perry, D.K.; Ryu, S.H.; Suh, P.G.
Proteolytic cleavage of epidermal growth factor receptor by caspases
FEBS Lett.
491
16-20
2001
Homo sapiens
Kisselev, A.F.; Garcia-Calvo, M.; Overkleeft, H.S.; Peterson, E.; Pennington, M.W.; Ploegh, H.L.; Thornberry, N.A.; Goldberg, A.L.
the caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites
J. Biol. Chem.
278
35869-35877
2003
Homo sapiens
Lippke, J.A.; Gu, Y.; Sarnecki, C.; Caron, P.R.; Su, M.S.S.
Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32
J. Biol. Chem.
271
1825-1828
1996
Homo sapiens (P55210)
Fernandes-Alnemri, T.; Takahashi, A.; Armstrong, R.C.; Krebs, J.; Fritz, L.C.; Tomaselli, K.J.; Wang, L.; Yu, Z.; Croce, C.M.; Salveson, G.; Earnshaw, W.C.; Litwack, G.; Alnemri, E.S.
Mch3, a novel human apoptotic cysteine protease highly related to CPP32
Cancer Res.
55
6045-6052
1995
Homo sapiens (P55210)
Juan, T.S.C.; McNiece, I.K.; Argento, J.M.; Jenkins, N.A.; Gilbert, D.J.; Copeland, N.G.; Fletcher, F.A.
Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3
Genomics
40
86-93
1997
Homo sapiens (P55210), Homo sapiens, Mus musculus (P97864), Mus musculus
Pai J.T.; Brown M.S.; Goldstein J.L.
Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins
Proc. Natl. Acad. Sci. USA
93
5437-5442
1996
Mesocricetus auratus (P55214)
Machleidt, T.; Geller, P.; Schwandner, R.; Scherer, G.; Kronke, M.
Caspase 7-induced cleavage of kinectin in apoptotic cells
FEBS Lett.
436
51-54
1998
Homo sapiens
Ethell, D.W.; Bossy-Wetzel, E.; Bredesen, D.E.
Caspase 7 can cleave tumor necrosis factor receptor-I (p60) at a non-consensus motif, in vitro
Biochim. Biophys. Acta
1541
231-238
2001
Homo sapiens
Riedl, S.J.; Fuentes-Prior, P.; Renatus, M.; Kairies, N.; Krapp, S.; Huber, R.; Salvesen, G.S.; Bode, W.
Structural basis for the activation of human procaspase-7
Proc. Natl. Acad. Sci. USA
98
14790-14795
2001
Homo sapiens (P55210), Homo sapiens
Yaoita, Y.
Inhibition of nuclear transport of caspase-7 by its prodomain
Biochem. Biophys. Res. Commun.
291
79-84
2002
Xenopus laevis
Behrensdorf, H.A.; van de Craen, M.; Knies, U.E.; Vandenabeele, P.; Clauss, M.
The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7
FEBS Lett.
466
143-147
2000
Mus musculus
Denault, J.B.; Salvesen, G.S.
Human caspase-7 activity and regulation by its N-terminal peptide
J. Biol. Chem.
278
34042-34050
2003
Homo sapiens
Duan, H.; Chinnaiyan, A.M.; Hudson, P.L.; Wing, J.P.; He, W.W.; Dixit, V.M.
ICE-LAP-3, a novel mammalian homologue at the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis
J. Biol. Chem.
271
1621-1625
1996
Homo sapiens (P55210)
Chiu, C.C.; Lin, C.H.; Fang, K.
Etoposide (VP-16) sensitizes p53-deficient human non-small cell lung cancer cells to caspase-7-mediated apoptosis
Apoptosis
10
643-650
2005
Homo sapiens
Yacobi, K.; Wojtowicz, A.; Tsafriri, A.; Gross, A.
Gonadotropins enhance caspase-3 and -7 activity and apoptosis in the theca-interstitial cells of rat preovulatory follicles in culture
Endocrinology
145
1943-1951
2004
Rattus norvegicus
Ohara, M.; Hayashi, T.; Kusunoki, Y.; Miyauchi, M.; Takata, T.; Sugai, M.
Caspase-2 and caspase-7 are involved in cytolethal distending toxin-induced apoptosis in Jurkat and MOLT-4 T-cell lines
Infect. Immun.
72
871-879
2004
Homo sapiens
Sironi, J.J.; Ouchi, T.
STAT1-induced apoptosis is mediated by caspases 2, 3, and 7
J. Biol. Chem.
279
4066-4074
2004
Homo sapiens
Clarke, C.A; Bennett, L.N.; Clarke, P.R.
Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway
J. Biol. Chem.
280
35337-35345
2005
Homo sapiens, Xenopus laevis
Twiddy, D.; Cohen, G.M.; Macfarlane, M.; Cain, K.
Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex
J. Biol. Chem.
281
3876-3888
2006
Homo sapiens
Fang, B.; Boross, P.I.; Tozser, J.; Weber, I.T.
Structural and kinetic analysis of caspase-3 reveals role for S5 binding site in substrate recognition
J. Mol. Biol.
360
654-666
2006
Homo sapiens
Houde, C.; Banks, K.G.; Coulombe, N.; Rasper, D.; Grimm, E.; Roy, S.; Simpson, E.M.; Nicholson, D.W.
Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice
J. Neurosci.
24
9977-9984
2004
Homo sapiens, Mus musculus
Hayashi, N.; Shirakura, H.; Uehara, T.; Nomura, Y.
Relationship between SUMO-1 modification of caspase-7 and its nuclear localization in human neuronal cells
Neurosci. Lett.
397
5-9
2006
Homo sapiens
Goode, D.R.; Sharma, A.K.; Hergenrother, P.J.
Using peptidic inhibitors to systematically probe the S1 site of caspase-3 and caspase-7
Org. Lett.
7
3529-3532
2005
Homo sapiens
Chen, D.; Texada, D.E.; Duggan, C.; Deng, Y.; Redens, T.B.; Langford, M.P.
Caspase-3 and -7 mediate apoptosis of human Chang's conjunctival cells induced by enterovirus 70
Virology
347
307-322
2006
Homo sapiens
Jang, M.; Park, B.C.; Lee, A.Y.; Na, K.S.; Kang, S.; Bae, K.H.; Myung, P.K.; Chung, B.C.; Cho, S.; Lee, d.o.H.; Park, S.G.
Caspase-7 mediated cleavage of proteasome subunits during apoptosis
Biochem. Biophys. Res. Commun.
363
388-394
2007
Homo sapiens
Song, J.J.; Lee, Y.J.
Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamily
Cell. Signal.
20
892-906
2008
Homo sapiens
Agniswamy, J.; Fang, B.; Weber, I.T.
Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis
FEBS J.
274
4752-4765
2007
Homo sapiens
Young, J.E.; Gouw, L.; Propp, S.; Sopher, B.L.; Taylor, J.; Lin, A.; Hermel, E.; Logvinova, A.; Chen, S.F.; Chen, S.; Bredesen, D.E.; Truant, R.; Ptacek, L.J.; La Spada, A.R.; Ellerby, L.M.
Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation
J. Biol. Chem.
282
30150-30160
2007
Homo sapiens
Schweigreiter, R.; Stasyk, T.; Contarini, I.; Frauscher, S.; Oertle, T.; Klimaschewski, L.; Huber, L.A.; Bandtlow, C.E.
Phosphorylation-regulated cleavage of the reticulon protein Nogo-B by caspase-7 at a noncanonical recognition site
Proteomics
7
4457-4467
2007
Homo sapiens
Garcia-Lozano, J.R.; Torres, B.; Fernandez, O.; Orozco, G.; Alvarez-Marquez, A.; Garcia, A.; Gonzalez-Gay, M.A.; Garcia, A.; Nunez-Roldan, A.; Martin, J.; Gonzalez-Escribano, M.F.
Caspase 7 influences susceptibility to rheumatoid arthritis
Rheumatology
46
1243-1247
2007
Homo sapiens
Li, I.T.; Pham, E.; Chiang, J.J.; Truong, K.
FRET evidence that an isoform of caspase-7 binds but does not cleave its substrate
Biochem. Biophys. Res. Commun.
373
325-329
2008
Homo sapiens
Podichetty, A.K.; Faust, A.; Kopka, K.; Wagner, S.; Schober, O.; Schaefers, M.; Haufe, G.
Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors
Bioorg. Med. Chem.
17
2680-2688
2009
Homo sapiens
Dorai, H.; Kyung, Y.S.; Ellis, D.; Kinney, C.; Lin, C.; Jan, D.; Moore, G.; Betenbaugh, M.J.
Expression of anti-apoptosis genes alters lactate metabolism of chinese hamster ovary cells in culture
Biotechnol. Bioeng.
103
592-608
2009
Cricetulus griseus
Lamkanfi, M.; Moreira, L.O.; Makena, P.; Spierings, D.C.; Boyd, K.; Murray, P.J.; Green, D.R.; Kanneganti, T.D.
Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival
Blood
113
2742-2745
2009
Mus musculus
Chan, Q.K.; Ngan, H.Y.; Ip, P.P.; Liu, V.W.; Xue, W.C.; Cheung, A.N.
Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis: a differential expression and functional analysis
Carcinogenesis
30
114-121
2009
Homo sapiens
Jen, C.Y.; Lin, C.Y.; Leu, S.F.; Huang, B.M.
Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis through caspase-9 pathway
Evid. Based. Complement Alternat. Med.
2009
1-10
2009
Mus musculus
Hashimoto, T.; Yamauchi, L.; Hunter, T.; Kikkawa, U.; Kamada, S.
Possible involvement of caspase-7 in cell cycle progression at mitosis
Genes Cells
13
609-621
2008
Homo sapiens
Frydrych, I.; Mlejnek, P.
Serine protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) do not inhibit caspase-3 and caspase-7 processing in cells exposed to pro-apoptotic inducing stimuli
J. Cell. Biochem.
105
1501-1506
2008
Homo sapiens
Bressenot, A.; Marchal, S.; Bezdetnaya, L.; Garrier, J.; Guillemin, F.; Plenat, F.
Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma
J. Histochem. Cytochem.
57
289-300
2009
Homo sapiens
Jung, E.J.; Kim, D.R.
Apoptotic cell death in TrkA-overexpressing cells: kinetic regulation of ERK phosphorylation and caspase-7 activation
Mol. Cells
26
12-17
2008
Homo sapiens
Jang, M.; Park, B.C.; Kang, S.; Lee, d.o..H.; Cho, S.; Lee, S.C.; Bae, K.H.; Park, S.G.
Mining of caspase-7 substrates using a degradomic approach
Mol. Cells
26
152-157
2008
Homo sapiens
Bondarava, M.; Li, T.; Endl, E.; Wehner, F.
alpha-ENaC is a functional element of the hypertonicity-induced cation channel in HepG2 cells and it mediates proliferation
Pflugers Arch.
458
675-687
2009
Homo sapiens
Siniscalco, D.; Giordano, C.; Fuccio, C.; Luongo, L.; Ferraraccio, F.; Rossi, F.; de Novellis, V.; Roth, K.A.; Maione, S.
Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats
Pharmacol. Res.
57
223-233
2008
Rattus norvegicus
Akhter, A.; Gavrilin, M.A.; Frantz, L.; Washington, S.; Ditty, C.; Limoli, D.; Day, C.; Sarkar, A.; Newland, C.; Butchar, J.; Marsh, C.B.; Wewers, M.D.; Tridandapani, S.; Kanneganti, T.D.; Amer, A.O.
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection
PLoS Pathog.
5
e1000361
2009
Mus musculus, Mus musculus C57BL/6
Stegh, A.H.; Kesari, S.; Mahoney, J.E.; Jenq, H.T.; Forloney, K.L.; Protopopov, A.; Louis, D.N.; Chin, L.; DePinho, R.A.
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma
Proc. Natl. Acad. Sci. USA
105
10703-10708
2008
Homo sapiens
Walsh, J.G.; Cullen, S.P.; Sheridan, C.; Luethi, A.U.; Gerner, C.; Martin, S.J.
Executioner caspase-3 and caspase-7 are functionally distinct proteases
Proc. Natl. Acad. Sci. USA
105
12815-12819
2008
Homo sapiens, Mus musculus
Karki, P.; Dahal, G.R.; Shin, S.Y.; Lee, J.S.; Cho, B.; Park, I.S.
Efficient cleavage of Bid and procaspase-7 by caspase-2 at lower pH
Protein Pept. Lett.
15
1044-1049
2008
Homo sapiens
Agniswamy, J.; Fang, B.; Weber, I.T.
Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7
Apoptosis
14
1135-1144
2009
Homo sapiens
Lee, Y.M.; Kang, H.J.; Jang, M.; Kim, M.; Bae, K.H.; Chung, S.J.
Large-scale expression in Escherichia coli and efficient purification of precursor and active caspase-7 by introduction of thrombin cleavage sites
Protein Expr. Purif.
69
29-33
2010
Homo sapiens
Soares, J.; Lowe, M.M.; Jarstfer, M.B.
The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate
Biochemistry
50
9046-9055
2011
Homo sapiens
Edelmann, B.; Bertsch, U.; Tchikov, V.; Winoto-Morbach, S.; Perrotta, C.; Jakob, M.; Adam-Klages, S.; Kabelitz, D.; Schuetze, S.
Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes
EMBO J.
30
379-394
2011
Homo sapiens
Majerciak, V.; Kruhlak, M.; Dagur, P.K.; McCoy, J.P.; Zheng, Z.M.
Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression
J. Biol. Chem.
285
11297-11307
2010
Homo sapiens
Nakatsumi, H.; Yonehara, S.
Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells
J. Biol. Chem.
285
25418-25425
2010
Homo sapiens (P55210), Homo sapiens
Miscione, G.P.; Calvaresi, M.; Bottoni, A.
Computational evidence for the catalytic mechanism of caspase-7. A DFT investigation
J. Phys. Chem. B
114
4637-4645
2010
Homo sapiens
Mills, E.; Chen, X.; Pham, E.; Wong, S.; Truong, K.
Engineering a photoactivated caspase-7 for rapid induction of apoptosis
ACS Synth. Biol.
1
75-82
2012
Homo sapiens
Matalova, E.; Vanden Berghe, T.; Svandova, E.; Vandenabeele, P.; Healy, C.; Sharpe, P.T.; Tucker, A.S.
Caspase-7 in molar tooth development
Arch. Oral Biol.
57
1474-1481
2012
Mus musculus
Cassel, J.A.; McDonnell, M.E.; Velvadapu, V.; Andrianov, V.; Reitz, A.B.
Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function
Biochimie
94
1974-1981
2012
Homo sapiens
Brentnall, M.; Rodriguez-Menocal, L.; De Guevara, R.L.; Cepero, E.; Boise, L.H.
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis
BMC Cell Biol.
14
32
2013
Mus musculus
Svandova, E.; Lesot, H.; Vanden Berghe, T.; Tucker, A.S.; Sharpe, P.T.; Vandenabeele, P.; Matalova, E.
Non-apoptotic functions of caspase-7 during osteogenesis
Cell Death Dis.
5
e1366
2014
Mus musculus
Matalova, E.; Lesot, H.; Svandova, E.; Vanden Berghe, T.; Sharpe, P.T.; Healy, C.; Vandenabeele, P.; Tucker, A.S.
Caspase-7 participates in differentiation of cells forming dental hard tissues
Dev. Growth Differ.
55
615-621
2013
Mus musculus
Cassidy, S.K.; Hagar, J.A.; Kanneganti, T.D.; Franchi, L.; Nunez, G.; ORiordan, M.X.
Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response
PLoS Pathog.
8
e1002628
2012
Mus musculus
Boucher, D.; Blais, V.; Denault, J.B.
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis
Proc. Natl. Acad. Sci. USA
109
5669-5674
2012
Homo sapiens (P55210)
Hill, M.E.; MacPherson, D.J.; Wu, P.; Julien, O.; Wells, J.A.; Hardy, J.A.
Reprogramming caspase-7 specificity by regio-specific mutations and selection provides alternate solutions for substrate recognition
ACS Chem. Biol.
11
1603-1612
2016
Homo sapiens (P55210), Homo sapiens
Vance, N.R.; Gakhar, L.; Spies, M.A.
Allosteric tuning of caspase-7 A fragment-based drug discovery approach
Angew. Chem. Int. Ed. Engl.
56
14443-14447
2017
Homo sapiens (P55210), Homo sapiens
Fu, S.; Ding, M.; Liu, H.; Wu, L.; Li, B.; Wang, A.; Liao, S.; Ye, J.
Identification and characterization of caspase-7 in pufferfish (Takifugu obscurus) in response to bacterial infection and cell apoptosis
Aquaculture
512
734268
2019
Takifugu obscurus
-
Martini, C.; Bedard, M.; Lavigne, P.; Denault, J.B.
Characterization of Hsp90 co-chaperone p23 cleavage by caspase-7 uncovers a peptidase-substrate interaction involving intrinsically disordered regions
Biochemistry
56
5099-5111
2017
Homo sapiens (P55210)
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