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acetyl-Tyr-Val-Ala-Asp-4-nitroanilide + H2O
acetyl-Tyr-Val-Ala-Asp + 4-nitroaniline
-
-
-
?
succinyl-YVAD-4-nitroanilide + H2O
succinyl-YVAD + 4-nitroaniline
-
-
-
?
Ac-Leu-Glu-Val-Asp-7-amido-4-trifluoro methylcoumarin + H2O
7-amino-4-trifluoromethylcoumarin + Ac-Leu-Glu-Val-Asp
-
10 microM, 2 h, 37°C, reaction stopped with HCl
-
-
?
acetyl-DEVD-4-nitroanilide + H2O
acetyl-DEVD + 4-nitroaniline
-
-
-
-
?
acetyl-DQMD-4-nitroanilide + H2O
acetyl-DQMD + 4-nitroaniline
-
-
-
-
?
acetyl-LEVD-4-nitroanilide + H2O
acetyl-LEVD + 4-nitroaniline
-
-
-
-
?
acetyl-LEVDGW-amide + H2O
?
-
preferred peptide substrate
-
-
?
acetyl-VEID-4-nitroanilide + H2O
acetyl-VEID + 4-nitroaniline
-
-
-
-
?
acetyl-VQVD-4-nitroanilide + H2O
acetyl-VQVD + 4-nitroaniline
-
-
-
-
?
acetyl-WEHD-7-amido-4-methylcoumarin + H2O
acetyl-WEHD + 7-amino-4-methylcoumarin
-
WEHD is the optimal tetrapeptide recognition motif
-
-
?
acetyl-YEVD-4-nitroanilide + H2O
acetyl-YEVD + 4-nitroaniline
-
-
-
-
?
acetyl-YVAD-4-nitroanilide + H2O
acetyl-YVAD + 4-nitroaniline
-
-
-
-
?
acetyl-YVAD-amido-4-methylcoumarin + H2O
acetyl-YVAD + amino-4-methylcoumarin
-
-
-
-
?
cowpox serpin CrmA + H2O
?
-
-
-
-
?
LEVD-7-amido-4-trifluoromethylcoumarin + H2O
LEVD + 7-amino-4-trifluoromethylcoumarin
-
-
-
-
?
poly(ADP-ribose)polymerase + H2O
?
-
-
-
-
?
pro-caspase-3 + H2O
p12 + pro-p17
-
-
-
?
procaspase-1 + H2O
caspase-1 + ?
procaspase-9 + H2O
caspase-9 + ?
succinyl-YVAD-4-nitroanilide + H2O
succinyl-YVAD + 4-nitroaniline
-
-
-
-
?
succinyl-YVAD-amido-4-methylcoumarin + H2O
succinyl-YVAD + amino-4-methylcoumarin
-
-
-
-
?
additional information
?
-
procaspase-1 + H2O
caspase-1 + ?
-
-
-
-
?
procaspase-1 + H2O
caspase-1 + ?
-
caspase-4 processes caspase-1 and enhances secretion of IL-1beta in transfected COS-1 cells
-
-
?
procaspase-9 + H2O
caspase-9 + ?
-
-
-
-
?
procaspase-9 + H2O
caspase-9 + ?
-
human recombinant active caspase-4 cleaves wild-type and D330A mutant caspase-9 at residue D315, but not the D315A mutant
-
-
?
additional information
?
-
overexpression of ICH-2 in insect cell induces apoptosis
-
-
?
additional information
?
-
the enzyme is capable of inducing apoptosis in transfected cells such as fibroblasts and may play a role in apoptotic cell death
-
-
?
pro-interleukin-1beta + H2O
additional information
-
-
generation of a small amount of mature interleukin-1beta after 120 min
?
additional information
?
-
-
the enzyme cleaves the substrates in the order of increasing efficiency: p35, pro-caspase-3, CrmA
-
-
?
additional information
?
-
-
the preferred cleavage sequence is WEHD-/- or LEHD-/-
-
-
?
additional information
?
-
-
the preferred cleavage sequence is WEHD-/- or LEHD-/-
-
-
?
additional information
?
-
-
the enzyme is involved in cytokine activation
-
-
?
additional information
?
-
-
the production of the enzyme induces activation of CPP32 like caspase
-
-
?
additional information
?
-
-
overexpression of the enzyme induces apoptosis
-
-
?
additional information
?
-
-
caspase-4 can function as an ER-stress-specific caspase in humans, and may be involved in pathogenesis of Alzheimer's disease
-
-
?
additional information
?
-
-
protective role of CARD only protein in Rip2/caspase-1/caspase-4-mediated HeLa cell death. CARD only protein binds and inhibits caspase-4 activation
-
-
?
additional information
?
-
-
familial Alzheimer's disease-linked presenilin-1 mutation accelerates the cleavage of caspase-4 under the endoplasmic reticulum stress and results in the activation of caspase-9 and caspase-3, apoptosis signal, without releasing cytochrome-c
-
-
?
additional information
?
-
-
misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms
-
-
?
additional information
?
-
-
caspase-4 physically interacts with its central molecule caspase-1
-
-
?
pro-interleukin-1beta + H2O
additional information
-
-
-
-
-
?
pro-interleukin-1beta + H2O
additional information
-
-
less efficient cleavage than with EC 3.4.22.36, caspase-1. The enzyme cleaves between YVHD116 and A117 to generate the 17500 Da mature active interleukin-1beta. An additional cleavage site between FEAD27 and G28 generates a 28000 Da intermediate form
-
?
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Adenocarcinoma
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.
Alzheimer Disease
Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress.
Alzheimer Disease
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death.
Alzheimer Disease
Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis.
Amyotrophic Lateral Sclerosis
Familiar amyotrophic lateral sclerosis (FALS)-linked SOD1 mutation accelerates neuronal cell death by activating cleavage of caspase-4 under ER stress in an in vitro model of FALS.
Arthritis, Rheumatoid
[Effect of ubiquitin-proteasome pathway on TRAIL inducing apoptosis]
Asthma
Caspase-11 promotes allergic airway inflammation.
Asthma
Elevated expression of the NLRP3 inflammasome in neutrophilic asthma.
Bacterial Infections
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.
Bacterial Infections
The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1? Secretion by Inflammasomes.
Blindness
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Brain Injuries
Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12.
Brain Injuries
Recombinant erythropoietin is neuroprotective in a novel mouse oxidative injury model.
Brain Ischemia
Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12.
Breast Neoplasms
Inhibition of mitogen-activated protein kinase signaling pathway sensitizes breast cancer cells to endoplasmic reticulum stress-induced apoptosis.
Breast Neoplasms
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Breast Neoplasms
Retraction Note: TET2 inhibits tumorigenesis of breast cancer cells by regulating caspase-4.
Breast Neoplasms
TET2 inhibits tumorigenesis of breast cancer cells by regulating caspase-4.
Breast Neoplasms
The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors.
Burkholderia Infections
Guanylate-Binding Protein-Dependent Noncanonical Inflammasome Activation Prevents Burkholderia thailandensis-Induced Multinucleated Giant Cell Formation.
Carcinogenesis
Inflammasomes of the intestinal epithelium.
Carcinogenesis
Retraction Note: TET2 inhibits tumorigenesis of breast cancer cells by regulating caspase-4.
Carcinogenesis
TET2 inhibits tumorigenesis of breast cancer cells by regulating caspase-4.
Carcinoma
A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.
Carcinoma
Caspase 4 Overexpression as a Prognostic Marker in Clear Cell Renal Cell Carcinoma: A Study Based on the Cancer Genome Atlas Data Mining.
Carcinoma
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Carcinoma
[Expression and correlation of apoptosis-related gene c-IAP2 and caspase-4 in head and cervical undifferentiation squamous cell carcinoma]
Carcinoma
[Expression and correlation of apoptosis-related gene c-IAP2 and caspase-4 in sinonasal squamous carcinoma]
Carcinoma, Non-Small-Cell Lung
Altered lung tissue lipidomic profile in caspase-4 positive non-small cell lung cancer (NSCLC) patients.
Carcinoma, Non-Small-Cell Lung
Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Correction: Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.
Carcinoma, Renal Cell
Caspase 4 Overexpression as a Prognostic Marker in Clear Cell Renal Cell Carcinoma: A Study Based on the Cancer Genome Atlas Data Mining.
Carcinoma, Squamous Cell
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.
Carcinoma, Squamous Cell
[Expression and correlation of apoptosis-related gene c-IAP2 and caspase-4 in head and cervical undifferentiation squamous cell carcinoma]
Carcinoma, Squamous Cell
[Expression and correlation of apoptosis-related gene c-IAP2 and caspase-4 in sinonasal squamous carcinoma]
Chorioamnionitis
A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis.
Chorioamnionitis
A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis.
Choriocarcinoma
Assessment of caspase-4 released free AFC by RP-HPLC and fluorescence detection.
Choriocarcinoma
Cell-specific RNA interference by peptide-inhibited-peptidase-activated siRNAs.
Colitis
Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis.
Colitis, Ulcerative
Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential.
Colitis, Ulcerative
Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis.
Colonic Neoplasms
Caspase-4 is essential for saikosaponin a-induced apoptosis acting upstream of caspase-2 and ?-H2AX in colon cancer cells.
Colorectal Neoplasms
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Colorectal Neoplasms
Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes.
Coronary Disease
Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis.
Cowpox
Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.
Cystinosis
Caspase-4 may play a role in loss of proximal tubules and renal injury in nephropathic cystinosis.
Dengue
Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection.
Epilepsy
[Apoptosis and expression of Caspase 3 and Caspase 4 in neurocytes of refractory human temporal lobe epilepsy].
Epilepsy, Temporal Lobe
[Apoptosis and expression of Caspase 3 and Caspase 4 in neurocytes of refractory human temporal lobe epilepsy].
Geographic Atrophy
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Glioma
Sulindac sulfide inhibits sarcoendoplasmic reticulum Ca2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: relevant similarities to and important differences from celecoxib.
Gram-Negative Bacterial Infections
A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells.
Gram-Negative Bacterial Infections
Dangerous Liaisons: Caspase-11 and Reactive Oxygen Species Crosstalk in Pathogen Elimination.
Hepatitis B, Chronic
[Study of endoplasmic reticulum stress role in hepatic failure induced by severe hepatitis B].
Hip Dislocation
Apoptotic pathways of macrophages within osteolytic interface membrane in periprosthestic osteolysis after total hip replacement.
Infections
Anti-Inflammatory Activity of PYNOD and Its Mechanism in Humans and Mice.
Infections
Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells.
Infections
Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.
Infections
Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12.
Infections
Dangerous Liaisons: Caspase-11 and Reactive Oxygen Species Crosstalk in Pathogen Elimination.
Infections
Development of an ex vivo Tissue Platform to Study the Human Lung Response to Coxiella burnetii.
Infections
Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions.
Infections
Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11.
Infections
Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection.
Infections
Modulation of the immune-related gene responses to protect mice against Japanese encephalitis virus using the antimicrobial peptide, tilapia hepcidin 1-5.
Infections
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.
Infections
Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes.
Infections
SERPINB1-mediated checkpoint of inflammatory caspase activation.
Infections
The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection.
Infections
TLR2 and Nod2 Mediate Resistance or Susceptibility to Fatal Intracellular Ehrlichia Infection in Murine Models of Ehrlichiosis.
Leukemia
Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis.
Liver Diseases
Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad.
Lung Injury
IGF2BP2 knockdown inhibits LPS-induced pyroptosis in BEAS-2B cells by targeting caspase 4, a crucial molecule of the non-canonical pyroptosis pathway.
Lung Neoplasms
Altered lung tissue lipidomic profile in caspase-4 positive non-small cell lung cancer (NSCLC) patients.
Lung Neoplasms
Calcium and survivin are involved in the induction of apoptosis by dihydroartemisinin in human lung cancer SPC-A-1 cells.
Lung Neoplasms
Celecoxib induces cell death on non-small cell lung cancer cells through endoplasmic reticulum stress.
Lung Neoplasms
Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer.
Lung Neoplasms
Correction: Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer.
Lung Neoplasms
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.
Lung Neoplasms
[Effect of Viqi Chutan Recipe on Caspase-4 and DNA-PK of Cell Apoptosis Approach in Transplanted Lung Cancer A549 Cells in Nude Mice].
Melanoma
A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis.
Melanoma
Caspase-4 is required for activation of inflammasomes.
Melanoma
Chinese Propolis Exerts Anti-Proliferation Effects in Human Melanoma Cells by Targeting NLRP1 Inflammatory Pathway, Inducing Apoptosis, Cell Cycle Arrest, and Autophagy.
Melanoma
Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells.
Melanoma
Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein.
Melanoma
Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis.
Melanoma
Proteomic analysis and the antimetastatic effect of N-(4-methyl)phenyl-O-(4-methoxy) phenyl-thionocarbamate-induced apoptosis in human melanoma SK-MEL-28 cells.
Melanoma
TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4.
Melanoma
Vitamin E ?-tocotrienol triggers endoplasmic reticulum stress-mediated apoptosis in human melanoma cells.
Mucocutaneous Lymph Node Syndrome
Correlation between NF-?B signal pathway-mediated caspase-4 activation and Kawasaki disease.
Neoplasms
1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol as a potential anticancer drug.
Neoplasms
A genome-wide RNA interference screen identifies caspase 4 as a factor required for tumor necrosis factor alpha signaling.
Neoplasms
Altered lung tissue lipidomic profile in caspase-4 positive non-small cell lung cancer (NSCLC) patients.
Neoplasms
Andrographolide-induced apoptosis in human renal tubular epithelial cells: Roles of endoplasmic reticulum stress and inflammatory response.
Neoplasms
Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib.
Neoplasms
Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity via ROS Pathways.
Neoplasms
Caspase 4 Overexpression as a Prognostic Marker in Clear Cell Renal Cell Carcinoma: A Study Based on the Cancer Genome Atlas Data Mining.
Neoplasms
Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer.
Neoplasms
Direct cytotoxicity produced by adenoviral-mediated interferon ? gene transfer in interferon-resistant cancer cells involves ER stress and caspase 4 activation.
Neoplasms
Enhancing cytotoxic and apoptotic effect in OVCAR-3 and MDAH-2774 cells with all-trans retinoic acid and zoledronic acid: a paradigm of synergistic molecular targeting treatment for ovarian cancer.
Neoplasms
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.
Neoplasms
Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity.
Neoplasms
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Neoplasms
Role of Smac in cephalostatin-induced cell death.
Neoplasms
TLR2 and Nod2 Mediate Resistance or Susceptibility to Fatal Intracellular Ehrlichia Infection in Murine Models of Ehrlichiosis.
Neoplasms
Tumor necrosis factor-alpha can provoke cleavage and activation of sterol regulatory element-binding protein in ethanol-exposed cells via a caspase-dependent pathway that is cholesterol insensitive.
Neoplasms
Vitamin E succinate suppresses prostate tumor growth by inducing apoptosis.
Neoplasms
[Effect of Viqi Chutan Recipe on Caspase-4 and DNA-PK of Cell Apoptosis Approach in Transplanted Lung Cancer A549 Cells in Nude Mice].
Neoplasms
[Expression and correlation of apoptosis-related gene c-IAP2 and caspase-4 in sinonasal squamous carcinoma]
Neuroblastoma
Homocysteine induces PUMA-mediated mitochondrial apoptosis in SH-SY5Y cells.
Neuroblastoma
NF-?B Regulates Caspase-4 Expression and Sensitizes Neuroblastoma Cells to Fas-Induced Apoptosis.
Neuroectodermal Tumors, Primitive
Endoplasmic Reticulum Stress in Pancreatic Neuroendocrine Tumors is Linked to Clinicopathological Parameters and Possible Epigenetic Regulations.
Obstetric Labor, Premature
A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis.
Ovarian Neoplasms
?-NETA induces pyroptosis of epithelial ovarian cancer cells through the GSDMD/caspase-4 pathway.
Pancreatic Neoplasms
Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.
Peptic Ulcer
Caspase-4: A Therapeutic Target for Peptic Ulcer Disease.
Periodontitis
Periodontal Inflammation-Triggered by Periodontal Ligament Stem Cell Pyroptosis Exacerbates Periodontitis.
Pneumonia
Bacterial Pore-Forming Toxins Promote the Activation of Caspases in Parallel to Necroptosis to Enhance Alarmin Release and Inflammation During Pneumonia.
Pulmonary Disease, Chronic Obstructive
Chronic Obstructive Pulmonary Disease-Derived Circulating Cells Release IL-18 and IL-33 under Ultrafine Particulate Matter Exposure in a Caspase-1/8-Independent Manner.
Pulmonary Disease, Chronic Obstructive
Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer.
Salmonella Infections
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.
Sepsis
A critical role for human caspase-4 in endotoxin sensitivity.
Sepsis
Cathepsin B regulates non-canonical NLRP3 inflammasome pathway by modulating activation of caspase-11 in Kupffer cells.
Sepsis
Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity.
Sepsis
Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11.
Sepsis
Sphingosine-1-phosphate Receptor 2 Signaling Promotes Caspase-11-dependent Macrophage Pyroptosis and Worsens Escherichia coli Sepsis Outcome.
Shock, Septic
A critical role for human caspase-4 in endotoxin sensitivity.
Shock, Septic
Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis.
Shock, Septic
The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.
Starvation
Inhibition of CLIC4 enhances autophagy and triggers mitochondrial and ER stress-induced apoptosis in human glioma U251 cells under starvation.
Stomach Ulcer
Caspase-4 activation in association with decreased adenosine deaminase activity may be a factor for gastric ulcer.
Teratocarcinoma
ER Stress-Mediated Apoptotic Pathway Induced by Amyloid-beta.
Virus Diseases
Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection.
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Garcia-Calvo, M.; Peterson, E.P.; Leiting, B.; Ruel, R.; Nicholson, D.W.; Thornberry, N.A.
Inhibition of human caspases by peptide-based and macromolecular inhibitors
J. Biol. Chem.
273
32608-32613
1998
Homo sapiens
brenda
Garcia-Calvo, M.; Peterson, E.P.; Rasper, D.M.; Vaillancourt, J.P.; Zamboni, R.; Nicholson, D.W.; Thornberry, N.A.
Purification and catalytic properties of human caspase family members
Cell Death Differ.
6
362-369
1999
Homo sapiens
brenda
Chang, H.Y.; Yang, X.
Proteases from cell suicide: functions and regulation of caspases
Microbiol. Mol. Biol. Rev.
64
821-846
2000
Homo sapiens
brenda
Thornberry, N.A.; Rano, T.A.; Peterson, E.P.; et al.
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
J. Biol. Chem.
272
17907-17911
1997
Homo sapiens
brenda
Talanian, R.V.; Quinlan, C.; Trautz, S.; Hackett, M.C.; Mankovich, J.A.; Banach, D.; Ghayur, T.; Brady, K.D.; Wong, W.W.
Substrate specificities of caspase family proteases
J. Biol. Chem.
272
9677-9682
1997
Homo sapiens
brenda
Margolin, N.; Raybuck, S.A.; Wilson, K.P.; Chen, W.; Fox, T.; Gu, Y.; Livingston, D.J.
Substrate and inhibitor specificity of interleukin-1beta-converting enzyme and related caspases
J. Biol. Chem.
272
7223-7228
1997
Homo sapiens
brenda
Munday N.A.; Vaillancourt J.P.; Ali A.; Casano F.J.; Miller D.K.; Molineaux S.M.; Yamin T.T.; Yu V.L.; Nicholson D.W.
Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases
J. Biol. Chem.
270
15870-15876
1995
Homo sapiens (P49662)
brenda
Kamada, S.; Funahashi, Y.; Tsujimoto, Y.
Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases
Cell Death Differ.
4
473-478
1997
Homo sapiens
brenda
Fassy, F.; Krebs, O.; Rey, H.; Komara, B.; Gillard, C.; Capdevila, C.; Yea, C.; Faucheu, C.; Blanchet, A.M.; Miossec, C.; Diu-Hercend, A.
Enzymic activity of two caspases related to interleukin-1beta-converting enzyme
Eur. J. Biochem.
253
76-83
1998
Homo sapiens
brenda
Faucheu, C.; Diu, A.; Chan, A.W.E.; Blanchet, A.M.; Miossec, C.; Herve, F.; Collard-Dutilleul, V.; Gu, Y.; Aldape, R.A.; Lippke, J.A.; Rocher, C.; Su, M.S.S.; Livingston, D.J.; Hercend, T.; Lalanne, J.L.
A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells
EMBO J.
14
1914-1922
1995
Homo sapiens (P49662)
brenda
Kamens, J.; Paskind, M.; Hugunin, M.; Talanian, R.V.; Allen, H.; Banach, D.; Bump, N.J.; Hackett, M.C.; Johnston, C.G.; Li, P.; Mankovich, J.A.; Terranova, M.; Ghayur, T.
Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases
J. Biol. Chem.
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Homo sapiens
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Homo sapiens (P49662), Homo sapiens
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Homo sapiens
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FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4
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Homo sapiens, no activity in Mus musculus
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Homo sapiens
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Valentin-Acevedo, A.; Sinquett, F.L.; Covey, L.R.
c-Rel deficiency increases caspase-4 expression and leads to ER stress and necrosis in EBV-transformed cells
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Homo sapiens
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Kobayashi, T.; Ogawa, M.; Sanada, T.; Mimuro, H.; Kim, M.; Ashida, H.; Akakura, R.; Yoshida, M.; Kawalec, M.; Reichhart, J.M.; Mizushima, T.; Sasakawa, C.
The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection
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Cavia porcellus, Homo sapiens
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Grimstad, O.; Husebye, H.; Espevik, T.
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Homo sapiens
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NF-kappaB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis
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Homo sapiens
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Schmid-Burgk, J.L.; Gaidt, M.M.; Schmidt, T.; Ebert, T.S.; Bartok, E.; Hornung, V.
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Homo sapiens (P49662), Homo sapiens
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Vigano, E.; Diamond, C.E.; Spreafico, R.; Balachander, A.; Sobota, R.M.; Mortellaro, A.
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Homo sapiens (P49662), Homo sapiens
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Lagrange, B.; Benaoudia, S.; Wallet, P.; Magnotti, F.; Provost, A.; Michal, F.; Martin, A.; Di Lorenzo, F.; Py, B.F.; Molinaro, A.; Henry, T.
Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
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Homo sapiens (P49662), Homo sapiens
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Casson, C.N.; Yu, J.; Reyes, V.M.; Taschuk, F.O.; Yadav, A.; Copenhaver, A.M.; Nguyen, H.T.; Collman, R.G.; Shin, S.
Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens
Proc. Natl. Acad. Sci. USA
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Homo sapiens (P49662), Homo sapiens
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An, J.; Kim, S.H.; Hwang, D.; Lee, K.E.; Kim, M.J.; Yang, E.G.; Kim, S.Y.; Chung, H.S.
Caspase-4 disaggregates lipopolysaccharide micelles via LPS-CARD interaction
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Homo sapiens (P49662), Homo sapiens
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