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Information on EC 3.4.22.56 - caspase-3 and Organism(s) Xenopus laevis and UniProt Accession P55866

for references in articles please use BRENDA:EC3.4.22.56
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.56 caspase-3
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This record set is specific for:
Xenopus laevis
UNIPROT: P55866 not found.
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Word Map
The taxonomic range for the selected organisms is: Xenopus laevis
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-/- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position
Synonyms
caspase-3, caspase 3, casp3, sca-1, cpp32, casp-3, cas-3, cpp-32, apopain, cgcaspase-3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
apopain
-
-
-
-
C14.003
-
-
-
-
CASP-3
-
-
-
-
caspase 3
-
-
-
-
CPP-32
-
-
-
-
CPP32
-
-
-
-
CPP32/apopain
-
-
-
-
cysteine protease CPP32
-
-
-
-
IRP
-
-
-
-
SCA-1
-
-
-
-
SREBP cleavage activity 1
-
-
-
-
Yama protein
-
-
-
-
Yama/CPP32
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
169592-56-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
derived from tadpole tail
Manually annotated by BRENDA team
myoblast cell line derived from tadpole tail
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CASP3_XENLA
282
0
32125
Swiss-Prot
other Location (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nakajima, K.; Takahashi, A.; Yaoita, Y.
Structure, expression, and function of the Xenopus laevis caspase family
J. Biol. Chem.
275
10484-10491
2000
Xenopus laevis
Manually annotated by BRENDA team
Yaoita, Y.; Nakajima, K.
Induction of apoptosis and CPP32 expression by thyroid hormone in a myoblastic cell line derived from tadpole tail
J. Biol. Chem.
272
5122-5127
1997
Xenopus laevis (P55866), Xenopus laevis
Manually annotated by BRENDA team