Reference on EC 3.4.22.55 - caspase-2
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Garcia-Calvo, M.; Peterson, E.P.; Leiting, B.; Ruel, R.; Nicholson, D.W.; Thornberry, N.A.
Inhibition of human caspases by peptide-based and macromolecular inhibitors
J. Biol. Chem.
273
32608-32613
1998
Homo sapiens
Garcia-Calvo, M.; Peterson, E.P.; Rasper, D.M.; Vaillancourt, J.P.; Zamboni, R.; Nicholson, D.W.; Thornberry, N.A.
Purification and catalytic properties of human caspase family members
Cell Death Differ.
6
362-369
1999
Homo sapiens
Chang, H.Y.; Yang, X.
Proteases from cell suicide: functions and regulation of caspases
Microbiol. Mol. Biol. Rev.
64
821-846
2000
Homo sapiens, Mus musculus
Thornberry, N.A.; Rano, T.A.; Peterson, E.P.; et al.
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
J. Biol. Chem.
272
17907-17911
1997
Homo sapiens
van de Craen, M.; Vandenabeele, P.; Declercq, W.; van den Brande, I.; van Loo, G.; Molemans, F.; Schotte, P.; van Criekinge, W.; Beyaert, R.; Fiers, W.
Characterization of seven murine caspase family members
FEBS Lett.
403
61-69
1997
Mus musculus (P29594), Mus musculus C3H/An (P29594)
Talanian, R.V.; Quinlan, C.; Trautz, S.; Hackett, M.C.; Mankovich, J.A.; Banach, D.; Ghayur, T.; Brady, K.D.; Wong, W.W.
Substrate specificities of caspase family proteases
J. Biol. Chem.
272
9677-9682
1997
Homo sapiens
Flaws, J.A.; Kugu, K.; Trbovich, A.M.; Desanti, A.; Tilly, K.I.; Hirshfield, A.N.; Tilly, J.L.
Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle
Endocrinology
136
5042-5053
1995
Rattus norvegicus (P55215)
Wang, L.; Miura M.; Bergeron, L.; Zhu, H.; Yuan, J.
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death
Cell
78
739-750
1994
Homo sapiens (P42575)
Xue, D.; Shaham, S.; Horvitz, H.R.
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease
Genes Dev.
10
1073-1083
1996
Homo sapiens (P42575)
Kumar, S.; Kinoshita, M.; Noda, M.; Copeland, N.G.; Jenkins, N.A.
Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme
Genes Dev.
8
1613-1626
1994
Mus musculus (P29594), Mus musculus BALB/c (P29594)
Kumar, S.; Tomooka, Y.; Noda, M.
Identification of a set of genes with developmentally down-regulated expression in the mouse brain
Biochem. Biophys. Res. Commun.
185
1155-1161
1992
Mus musculus (P29594)
Kaushal, G.P.; Singh, A.B.; Shah, S.V.
Identification of gene family of caspases in rat kidney and altered expression in ischemia-reperfusion injury
Am. J. Physiol.
274
F587-F595
1998
Rattus norvegicus (P55215)
Johnson, A.L.; Bridgham, J.T.; Bergeron, L.; Yuan, J.
Characterization of the avian Ich-1 cDNA and expression of Ich-1L mRNA in the hen ovary
Gene
192
227-233
1997
Gallus gallus (Q98943), Gallus gallus
Mancini, M.; Machamer, C.E.; Roy, S.; Nicholson, D.W.; Thornberry, N.A.; Casciola-Rosen, L.A.; Rosen, A.
Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis
J. Cell. Biol.
149
603-612
2000
Homo sapiens
Colussi, P.A.; Harvey, N.L.; Shearwin-Whyatt, L.M.; Kumar, S.
Conversion of procaspase-3 to an autoactivating caspase by fusion to the caspase-2 prodomain
J. Biol. Chem.
273
26566-26570
1998
Mus musculus
Baliga, B.C.; Colussi, P.A.; Read, S.H.; Dias, M.M.; Jans, D.A.; Kumar, S.
Role of prodomain in importin-mediated nuclear localization and activation of caspase-2
J. Biol. Chem.
278
4899-4905
2003
Mus musculus
Li, H.; Bergeron, L.; Cryns, V.; Pasternack, M.S.; Zhu, H.; Shi, L.; Greenberg, A.; Yuan, J.
Activation of caspase-2 in apoptosis
J. Biol. Chem.
272
21010-21017
1997
Homo sapiens
Zhivotovsky, B.; Orrenius, S.
Caspase-2 function in response to DNA damage
Biochem. Biophys. Res. Commun.
331
859-867
2005
Homo sapiens (P42575)
Zheng, S.; Turner, T.T.; Lysiak, J.J.
Caspase 2 activity contributes to the initial wave of germ cell apoptosis during the first round of spermatogenesis
Biol. Reprod.
74
1026-1033
2006
Mus musculus (P29594), Mus musculus, Mus musculus C57BL/6 (P29594)
Tyagi, A.; Singh, R.P.; Agarwal, C.; Agarwal, R.
Silibinin activates p53-caspase-2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase-2
Carcinogenesis
27
2269-2280
2006
Homo sapiens (P42575), Homo sapiens
Kong, J.Y.; Rabkin, S.W.
Cytoskeletal actin degradation induced by lovastatin in cardiomyocytes is mediated through caspase-2
Cell Biol. Int.
28
781-790
2004
Gallus gallus (Q98943)
Shin, S.; Lee, Y.; Kim, W.; Ko, H.; Choi, H.; Kim, K.
Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8
EMBO J.
24
3532-3542
2005
Homo sapiens (P42575)
Cheung, H.H.; Lynn Kelly, N.; Liston, P.; Korneluk, R.G.
Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: a role for the IAPs
Exp. Cell Res.
312
2347-2357
2006
Homo sapiens (P42575)
Ho, P.K.; Jabbour, A.M.; Ekert, P.G.; Hawkins, C.J.
Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7
FEBS J.
272
1401-1414
2005
Homo sapiens (P42575), Homo sapiens
Cristobal, J.; Stockert, J.C.; Villanueva, A.; Rello-Varona, S.; Juarranz, A.; Canete, M.
Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment
Int. J. Oncol.
28
1057-1063
2006
Homo sapiens (P42575)
Wagner, K.W.; Engels, I.H.; Deveraux, Q.L.
Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway
J. Biol. Chem.
279
35047-35052
2004
Homo sapiens (P42575)
Enoksson, M.; Robertson, J.D.; Gogvadze, V.; Bu, P.; Kropotov, A.; Zhivotovsky, B.; Orrenius, S.
Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids
J. Biol. Chem.
279
49575-49578
2004
Homo sapiens (P42575)
Iwanaga, N.; Kamachi, M.; Aratake, K.; Izumi, Y.; Ida, H.; Tanaka, F.; Tamai, M.; Arima, K.; Nakamura, H.; Origuchi, T.; Kawakami, A.; Eguchi, K.
Regulation of alternative splicing of caspase-2 through an intracellular signaling pathway in response to pro-apoptotic stimuli
J. Lab. Clin. Med.
145
105-110
2005
Homo sapiens (P42575)
Bonzon, C.; Bouchier-Hayes, L.; Pagliari, L.J.; Green, D.R.; Newmeyer, D.D.
Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death
Mol. Biol. Cell
17
2150-2157
2006
Mus musculus (P29594), Mus musculus, Xenopus laevis (Q9IB67)
Logette, E.; Le Jossic-Corcos, C.; Masson, D.; Solier, S.; Sequeira-Legrand, A.; Dugail, I.; Lemaire-Ewing, S.; Desoche, L.; Solary, E.; Corcos, L.
Caspase-2, a novel lipid sensor under the control of sterol regulatory element binding protein 2
Mol. Cell. Biol.
25
9621-9631
2005
Homo sapiens (P42575), Homo sapiens
Tu, S.; McStay, G.P.; Boucher, L.M.; Mak, T.; Beere, H.M.; Green, D.R.
In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis
Nat. Cell Biol.
8
72-77
2006
Mus musculus (P29594)
Filomenko, R.; Prvotat, L.; Rb, C.; Cortier, M.; Jeannin, J.F.; Solary, E.; Bettaieb, A.
Caspase-10 involvement in cytotoxic drug-induced apoptosis of tumor cells
Oncogene
2006
1-11
2006
Homo sapiens (P42575)
-
Peluffo, M.C.; Bussmann, L.; Stouffer, R.L.; Tesone, M.
Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle
Reproduction
132
465-475
2006
Rattus norvegicus (P55215)
Lysiak, J.J.; Zheng, S.; Woodson, R.; Turner, T.T.
Caspase-9-dependent pathway to murine germ cell apoptosis: mediation by oxidative stress, BAX, and caspase 2
Cell Tissue Res.
328
411-419
2007
Mus musculus
VanOosten, R.L.; Earel, J.K.; Griffith, T.S.
Histone deacetylase inhibitors enhance Ad5-TRAIL killing of TRAIL-resistant prostate tumor cells through increased caspase-2 activity
Apoptosis
12
561-571
2007
Homo sapiens
Sapet, C.; Simoncini, S.; Loriod, B.; Puthier, D.; Sampol, J.; Nguyen, C.; Dignat-George, F.; Anfosso, F.
Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2
Blood
108
1868-1876
2006
Homo sapiens
Taghiyev, A.F.; Guseva, N.V.; Glover, R.A.; Rokhlin, O.W.; Cohen, M.B.
TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome
Cancer Biol. Ther.
5
1199-1205
2006
Homo sapiens
Jangi, S.M.; Diaz-Perez, J.L.; Ochoa-Lizarralde, B.; Martin-Ruiz, I.; Asumendi, A.; Perez-Yarza, G.; Gardeazabal, J.; Diaz-Ramon, J.L.; Boyano, M.D.
H1 histamine receptor antagonists induce genotoxic and caspase-2-dependent apoptosis in human melanoma cells
Carcinogenesis
27
1787-1796
2006
Homo sapiens
Hanoux, V.; Pairault, C.; Bakalska, M.; Habert, R.; Livera, G.
Caspase-2 involvement during ionizing radiation-induced oocyte death in the mouse ovary
Cell Death Differ.
14
671-681
2007
Mus musculus
Yeung, B.H.; Huang, D.C.; Sinicrope, F.A.
PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells
J. Biol. Chem.
281
11923-11932
2006
Homo sapiens
Mohan, J.; Gandhi, A.A.; Bhavya, B.C.; Rashmi, R.; Karunagaran, D.; Indu, R.; Santhoshkumar, T.R.
Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol
J. Biol. Chem.
281
17599-17611
2006
Homo sapiens, Mus musculus
Cao, X.; Bennett, R.L.; May, W.S.
c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis
J. Biol. Chem.
283
14490-14496
2008
Homo sapiens
Upton, J.P.; Austgen, K.; Nishino, M.; Coakley, K.M.; Hagen, A.; Han, D.; Papa, F.R.; Oakes, S.A.
Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress
Mol. Cell. Biol.
28
3943-3951
2008
Mus musculus
Ho, L.H.; Read, S.H.; Dorstyn, L.; Lambrusco, L.; Kumar, S.
Caspase-2 is required for cell death induced by cytoskeletal disruption
Oncogene
27
3393-3404
2008
Mus musculus
Baptiste-Okoh, N.; Barsotti, A.M.; Prives, C.
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis
Proc. Natl. Acad. Sci. USA
105
1937-1942
2008
Homo sapiens
Karki, P.; Dahal, G.R.; Shin, S.Y.; Lee, J.S.; Cho, B.; Park, I.S.
Efficient cleavage of Bid and procaspase-7 by caspase-2 at lower pH
Protein Pept. Lett.
15
1044-1049
2008
Homo sapiens
Chae, S.S.; Yoo, C.B.; Jo, C.; Yun, S.M.; Jo, S.A.; Koh, Y.H.
Caspases-2 and -8 are involved in the presenilin1/gamma-secretase-dependent cleavage of amyloid precursor protein after the induction of apoptosis
J. Neurosci. Res.
88
1926-1933
2010
Homo sapiens
Chan, K.M.; Rajab, N.F.; Siegel, D.; Din, L.B.; Ross, D.; Inayat-Hussain, S.H.
Goniothalamin induces coronary artery smooth muscle cells apoptosis: the p53-dependent caspase-2 activation pathway
Toxicol. Sci.
116
533-548
2010
Homo sapiens
Kitevska, T.; Spencer, D.M.; Hawkins, C.J.
Caspase-2: controversial killer or checkpoint controller?
Apoptosis
14
829-848
2009
Homo sapiens (P42575)
Lee, J.C.; Su, C.L.; Chen, L.L.; Won, S.J.
Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential
Cancer Sci.
100
503-513
2009
Homo sapiens
Krumschnabel, G.; Sohm, B.; Bock, F.; Manzl, C.; Villunger, A.
The enigma of caspase-2: The laymens view
Cell Death Differ.
16
195-207
2009
Homo sapiens, Mus musculus
Shi, M.; Vivian, C.J.; Lee, K.J.; Ge, C.; Morotomi-Yano, K.; Manzl, C.; Bock, F.; Sato, S.; Tomomori-Sato, C.; Zhu, R.; Haug, J.S.; Swanson, S.K.; Washburn, M.P.; Chen, D.J.; Chen, B.P.; Villunger, A.; Florens, L.; Du, C.
DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance
Cell
136
508-520
2009
Homo sapiens, Mus musculus
Nutt, L.K.; Buchakjian, M.R.; Gan, E.; Darbandi, R.; Yoon, S.Y.; Wu, J.Q.; Miyamoto, Y.J.; Gibbons, J.A.; Gibbon, J.A.; Andersen, J.L.; Freel, C.D.; Tang, W.; He, C.; Kurokawa, M.; Wang, Y.; Margolis, S.S.; Fissore, R.A.; Kornbluth, S.
Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2
Dev. Cell
16
856-866
2009
Xenopus laevis
Narine, K.A.; Keuling, A.M.; Gombos, R.; Tron, V.A.; Andrew, S.E.; Young, L.C.
Defining the DNA mismatch repair-dependent apoptotic pathway in primary cells: evidence for p53-independence and involvement of centrosomal caspase 2
DNA Repair
9
161-168
2010
Mus musculus
Andersen, J.L.; Johnson, C.E.; Freel, C.D.; Parrish, A.B.; Day, J.L.; Buchakjian, M.R.; Nutt, L.K.; Thompson, J.W.; Moseley, M.A.; Kornbluth, S.
Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2
EMBO J.
28
3216-3227
2009
Homo sapiens, Xenopus laevis
Manzl, C.; Krumschnabel, G.; Bock, F.; Sohm, B.; Labi, V.; Baumgartner, F.; Logette, E.; Tschopp, J.; Villunger, A.
Caspase-2 activation in the absence of PIDDosome formation
J. Cell Biol.
185
291-303
2009
Mus musculus
Bouchier-Hayes, L.
The role of caspase-2 in stress-induced apoptosis
J. Cell. Mol. Med.
14
1212-1224
2010
Homo sapiens, Mus musculus
Kamiya, T.; Okabayashi, T.; Yokota, S.; Kan, Y.; Ogino, J.; Yamashita, T.; Fujii, N.; Jimbow, K.
Increased caspase-2 activity is associated with induction of apoptosis in IFN-beta sensitive melanoma cell lines
J. Interferon Cytokine Res.
30
349-357
2010
Homo sapiens
Bouchier-Hayes, L.; Oberst, A.; McStay, G.P.; Connell, S.; Tait, S.W.; Dillon, C.P.; Flanagan, J.M.; Beere, H.M.; Green, D.R.
Characterization of cytoplasmic caspase-2 activation by induced proximity
Mol. Cell
35
830-840
2009
Homo sapiens
Kumar, S.
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
Nat. Rev. Cancer
9
897-903
2009
Mus musculus
Olsson, M.; Vakifahmetoglu, H.; Abruzzo, P.M.; Hoegstrand, K.; Grandien, A.; Zhivotovsky, B.
DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis
Oncogene
28
1949-1959
2009
Homo sapiens
Krumschnabel, G.; Manzl, C.; Villunger, A.
Caspase-2: killer, savior and safeguard-emerging versatile roles for an ill-defined caspase
Oncogene
28
3093-3096
2009
Mus musculus
Guha, M.; Xia, F.; Raskett, C.M.; Altieri, D.C.
Caspase 2-mediated tumor suppression involves survivin gene silencing
Oncogene
29
1280-1292
2010
Homo sapiens
Chen, F.; He, Y.
Caspase-2 mediated apoptotic and necrotic murine macrophage cell death induced by rough Brucella abortus
PLoS ONE
4
e6830
2009
Mus musculus
Inayat-Hussain, S.H.; Chan, K.M.; Rajab, N.F.; Din, L.B.; Chow, S.C.; Kizilors, A.; Farzaneh, F.; Williams, G.T.
Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells
Toxicol. Lett.
193
108-114
2010
Homo sapiens
Vakifahmetoglu-Norberg, H.; Zhivotovsky, B.
The unpredictable caspase-2: what can it do?
Trends Cell Biol.
20
150-159
2010
Mus musculus
Sohn, D.; Budach, W.; Jaenicke, R.U.
Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1)
Cell Death Differ.
18
1664-1674
2011
Homo sapiens
Bouchier-Hayes, L.; Green, D.R.
Caspase-2: the orphan caspase
Cell Death Differ.
19
51-57
2012
Homo sapiens, Mus musculus
Tang, Y.; Wells, J.A.; Arkin, M.R.
Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis
J. Biol. Chem.
286
34147-34154
2011
Homo sapiens (P42575), Homo sapiens
Oliver, T.G.; Meylan, E.; Chang, G.P.; Xue, W.; Burke, J.R.; Humpton, T.J.; Hubbard, D.; Bhutkar, A.; Jacks, T.
Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop
Mol. Cell
43
57-71
2011
Homo sapiens
Jean, Y.Y.; Ribe, E.M.; Pero, M.E.; Moskalenko, M.; Iqbal, Z.; Marks, L.J.; Greene, L.A.; Troy, C.M.
Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death
Biochem. J.
455
15-25
2013
Rattus norvegicus (P55215)
Callaway, D.A.; Riquelme, M.A.; Sharma, R.; Lopez-Cruzan, M.; Herman, B.A.; Jiang, J.X.
Caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress
Bone
76
40-48
2015
Mus musculus (P29594)
Imre, G.; Rajalingam, K.
Role for caspase-2 during pore-forming toxin-mediated apoptosis
Cell Cycle
11
3709-3710
2012
Mus musculus (P29594)
Vakifahmetoglu-Norberg, H.; Norberg, E.; Perdomo, A.B.; Olsson, M.; Ciccosanti, F.; Orrenius, S.; Fimia, G.M.; Piacentini, M.; Zhivotovsky, B.
Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death
Cell Death Dis.
4
e940
2013
Homo sapiens (P42575)
Ren, K.; Lu, J.; Porollo, A.; Du, C.
Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice
J. Biol. Chem.
287
14792-14802
2012
Mus musculus (P29594), Mus musculus
Wejda, M.; Impens, F.; Takahashi, N.; Van Damme, P.; Gevaert, K.; Vandenabeele, P.
Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike
J. Biol. Chem.
287
33983-33995
2012
Homo sapiens (P42575), Homo sapiens
Johnson, E.S.; Lindblom, K.R.; Robeson, A.; Stevens, R.D.; Ilkayeva, O.R.; Newgard, C.B.; Kornbluth, S.; Andersen, J.L.
Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis
J. Biol. Chem.
288
14463-14475
2013
Xenopus laevis
Fava, L.; Bock, F.; Geley, S.; Villunger, A.
Caspase-2 at a glance
J. Cell Sci.
125
5911-5915
2012
Mus musculus (P29594)
Pozueta, J.; Lefort, R.; Ribe, E.M.; Troy, C.M.; Arancio, O.; Shelanski, M.
Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice
Nat. Commun.
4
1939
2013
Mus musculus (P29594), Mus musculus, Rattus norvegicus (P55215)
Olsson, M.; Forsberg, J.; Zhivotovsky, B.
Caspase-2: the reinvented enzyme
Oncogene
34
1877-1882
2015
Mus musculus (P29594), Mus musculus
Li, X.; He, Y.
Caspase-2-dependent dendritic cell death, maturation, and priming of T cells in response to Brucella abortus infection
PLoS ONE
7
e43512
2012
Mus musculus (P29594)
Han, C.; Zhao, R.; Kroger, J.; Qu, M.; Wani, A.A.; Wang, Q.E.
Caspase-2 short isoform interacts with membrane-associated cytoskeleton proteins to inhibit apoptosis
PLoS ONE
8
e67033
2013
Homo sapiens (P42575)
Boonstra, K.; Bloemberg, D.; Quadrilatero, J.
Caspase-2 is required for skeletal muscle differentiation and myogenesis
Biochim. Biophys. Acta Mol. Cell Res.
1865
95-104
2018
Mus musculus (P29594)
Lim, J.; Kim, H.K.; Kim, S.H.; Rhee, K.J.; Kim, Y.S.
Caspase-2 mediates triglyceride (TG)-induced macrophage cell death
BMB Rep.
50
510-515
2017
Mus musculus (P29594)
Peintner, L.; Dorstyn, L.; Kumar, S.; Aneichyk, T.; Villunger, A.; Manzl, C.
The tumor-modulatory effects of caspase-2 and Pidd1 do not require the scaffold protein Raidd
Cell Death Differ.
22
1803-1811
2015
Mus musculus (P29594), Mus musculus
Terry, M.; Arya, R.; Mukhopadhyay, A.; Berrett, K.; Clair, P.; Witt, B.; Salama, M.; Bhutkar, A.; Oliver, T.
Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo
Cell Death Differ.
22
719-730
2015
Homo sapiens (P42575), Homo sapiens
Lopez-Cruzan, M.; Sharma, R.; Tiwari, M.; Karbach, S.; Holstein, D.; Martin, C.R.; Lechleiter, J.D.; Herman, B.
Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment
Cell Death Dis.
2
16005
2016
Mus musculus (P29594)
Ye, S.; Gao, Y.; Wang, S.; Li, Q.; Li, R.; Li, H.
Characterization and expression analysis of a caspase-2 in an invertebrate echinoderm sea cumber Apostichopus japonicus
Fish Shellfish Immunol.
48
266-272
2016
Apostichopus japonicus (A0A139YJB0), Apostichopus japonicus
Thomas, C.N.; Thompson, A.M.; McCance, E.; Berry, M.; Logan, A.; Blanch, R.J.; Ahmed, Z.
Caspase-2 mediates site-specific retinal ganglion cell death after blunt ocular injury
Invest. Ophthalmol. Vis. Sci.
59
4453-4462
2018
Rattus norvegicus (P55215)
Zhao, X.; Kotilinek, L.A.; Smith, B.; Hlynialuk, C.; Zahs, K.; Ramsden, M.; Cleary, J.; Ashe, K.H.
Caspase-2 cleavage of tau reversibly impairs memory
Nat. Med.
22
1268-1276
2016
Mus musculus (P29594), Homo sapiens (P42575), Homo sapiens
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