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Information on EC 3.4.22.55 - caspase-2 and Organism(s) Rattus norvegicus and UniProt Accession P55215

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.55 caspase-2
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This record set is specific for:
Rattus norvegicus
UNIPROT: P55215 not found.
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The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
strict requirement for an Asp residue at P1, with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-/-
Synonyms
caspase-2, caspase 2, casp2, ich-1, casp-2, caspase-2l, nedd-2, caspase-2s, ajcasp, ich-1 protease, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C14.006
-
-
-
-
CASP-2
-
-
-
-
caspase 2
-
-
-
-
ICH-1 protease
-
-
-
-
ICH-1L/1S
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
182372-14-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CUX1 + H2O
?
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CUX1 + H2O
?
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
amyloid beta
treatment of rat hippocampal neuron extracts with either 300 nM or 0.001 mM amyloid beta leads to activation of caspase-2
-
biotinylated VAD-fluoromethylketone
irreversible pan-caspase inhibitor
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
amyloid beta1-42
the levels of activated caspase-2 in cultured hippocampal neurons significantly increase within 30 min of treatment with 0.003 mM amyloid beta1-42
-
RAIDD
caspase-2 activation is dependent on the adaptor protein RAIDD
-
additional information
caspase-2 is rapidly activated by nerve growth factor deprivation
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
immunostaining for caspase-2 increases as the luteal phase progresses
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
down-regulation or inactivation of caspase-2 blocks amyloid beta-mediated effects on primary hippocampal cultures
metabolism
caspase-2 is a critical mediator in the activation of the RhoA/ROCK-II signaling pathway, leading to the collapse of dendritic spines. Inactive RhoA-GDP but not active RhoA-GTP forms a complex with caspase-2
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CASP2_RAT
452
0
50728
Swiss-Prot
Mitochondrion (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45000
x * 45000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 45000, SDS-PAGE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
caspase-2 mediates death in a proportion of retinal ganglion cells but not photoreceptors at the site of blunt ocular trauma. Thus, intravitreally delivered siCASP2 is a possible therapeutic for the effective treatment of retinal ganglion cell death to prevent traumatic optic neuropathy
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Flaws, J.A.; Kugu, K.; Trbovich, A.M.; Desanti, A.; Tilly, K.I.; Hirshfield, A.N.; Tilly, J.L.
Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle
Endocrinology
136
5042-5053
1995
Rattus norvegicus (P55215)
Manually annotated by BRENDA team
Kaushal, G.P.; Singh, A.B.; Shah, S.V.
Identification of gene family of caspases in rat kidney and altered expression in ischemia-reperfusion injury
Am. J. Physiol.
274
F587-F595
1998
Rattus norvegicus (P55215)
Manually annotated by BRENDA team
Peluffo, M.C.; Bussmann, L.; Stouffer, R.L.; Tesone, M.
Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle
Reproduction
132
465-475
2006
Rattus norvegicus (P55215)
Manually annotated by BRENDA team
Jean, Y.Y.; Ribe, E.M.; Pero, M.E.; Moskalenko, M.; Iqbal, Z.; Marks, L.J.; Greene, L.A.; Troy, C.M.
Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death
Biochem. J.
455
15-25
2013
Rattus norvegicus (P55215)
Manually annotated by BRENDA team
Pozueta, J.; Lefort, R.; Ribe, E.M.; Troy, C.M.; Arancio, O.; Shelanski, M.
Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice
Nat. Commun.
4
1939
2013
Mus musculus (P29594), Mus musculus, Rattus norvegicus (P55215)
Manually annotated by BRENDA team
Thomas, C.N.; Thompson, A.M.; McCance, E.; Berry, M.; Logan, A.; Blanch, R.J.; Ahmed, Z.
Caspase-2 mediates site-specific retinal ganglion cell death after blunt ocular injury
Invest. Ophthalmol. Vis. Sci.
59
4453-4462
2018
Rattus norvegicus (P55215)
Manually annotated by BRENDA team