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Acrocephalosyndactylia
Twist haploinsufficiency in Saethre-Chotzen syndrome induces calvarial osteoblast apoptosis due to increased TNFalpha expression and caspase-2 activation.
Adenocarcinoma
Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L.
Adenocarcinoma of Lung
c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis.
Adenocarcinoma of Lung
Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway.
Adenoma, Pleomorphic
Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
Alzheimer Disease
A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease.
Alzheimer Disease
Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease.
Alzheimer Disease
Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice.
Alzheimer Disease
Changes in caspase expression in Alzheimer's disease: comparison with development and aging.
Alzheimer Disease
THD-Module Extractor: An Application for CEN Module Extraction and Interesting Gene Identification for Alzheimer's Disease.
Amyloidosis
The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market.
Astrocytoma
A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells.
Ataxia
Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function.
Ataxia Telangiectasia
Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome.
Babesiosis
Porin Expression Profiles in Haemaphysalis longicornis Infected With Babesia microti.
Bacterial Infections
Old and Novel Functions of Caspase-2.
Brain Injuries
Combined effect of hypothermia and caspase-2 gene deficiency on neonatal hypoxic-ischemic brain injury.
Brain Injuries
Genetic inhibition of caspase-2 reduces hypoxic-ischemic and excitotoxic neonatal brain injury.
Brain Ischemia
Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemia.
Brain Neoplasms
Gene expression profiling of metastatic brain cancer.
Breast Neoplasms
A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway.
Breast Neoplasms
Biphasic dose-dependent effect of lithium chloride on survival of human hormone-dependent breast cancer cells (mcf-7).
Breast Neoplasms
Caspase-2 is involved in cell death induction by taxanes in breast cancer cells.
Breast Neoplasms
Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.
Breast Neoplasms
Importance of transcript levels of caspase-2 isoforms S and L for breast carcinoma progression.
Breast Neoplasms
Long non-coding RNA TPT1-AS1 sensitizes breast cancer cell to paclitaxel and inhibits cell proliferation by miR-3156-5p/caspase 2 axis.
Breast Neoplasms
Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac).
Breast Neoplasms
Role of specific apoptotic pathways in the restoration of paclitaxel-induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer cells.
Breast Neoplasms
The nuclear receptor interacting factor-3 transcriptional coregulator mediates rapid apoptosis in breast cancer cells through direct and bystander-mediated events.
Breast Neoplasms
The potential role of free chitosan in bone trauma and bone cancer management.
Breast Neoplasms
The role of individual caspases in cell death induction by taxanes in breast cancer cells.
Carcinogenesis
A tumor suppressor function for caspase-2.
Carcinogenesis
An unexpected role for caspase-2 in neuroblastoma.
Carcinogenesis
Caspase-2 as a master regulator of genomic stability.
Carcinogenesis
Caspase-2 as a tumour suppressor.
Carcinogenesis
Caspase-2 deficiency accelerates chemically induced liver cancer in mice.
Carcinogenesis
Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.
Carcinogenesis
Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice.
Carcinogenesis
Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.
Carcinogenesis
Old, new and emerging functions of caspases.
Carcinogenesis
Tumor-suppressing function of caspase-2 requires catalytic site C320 and site S139 in mice.
Carcinogenesis
Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells.
Carcinogenesis
[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]
Carcinoma
Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L.
Carcinoma
Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines.
Carcinoma
Caspase-2 is a negative regulator of necroptosis.
Carcinoma
Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1).
Carcinoma
DNA damage induces two distinct modes of cell death in ovarian carcinomas.
Carcinoma
Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage.
Carcinoma
Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis.
Carcinoma
Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?
Carcinoma
Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells.
Carcinoma
Loss of caspase-2, -6 and -7 expression in gastric cancers.
Carcinoma
miR-708 promotes the development of bladder carcinoma via direct repression of Caspase-2.
Carcinoma
PIDDosome expression and the role of caspase-2 activation for chemotherapy-induced apoptosis in RCCs.
Carcinoma
PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells.
Carcinoma
Rescue from enhanced alkylator-induced cell death with low molecular weight sulfur-containing chemoprotectants.
Carcinoma
Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines.
Carcinoma
Somatic mutations of caspase-2 gene in gastric and colorectal cancers.
Carcinoma
TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death.
Carcinoma
The association of taxane resistance genes with the clinical course of ovarian carcinoma.
Carcinoma
Topoisomerase I and II inhibitors control caspase-2 pre-messenger RNA splicing in human cells.
Carcinoma
Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis.
Carcinoma, Hepatocellular
Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis.
Carcinoma, Hepatocellular
[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]
Carcinoma, Mucoepidermoid
Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
Carcinoma, Non-Small-Cell Lung
MiR-494 acts as a tumor promoter by targeting CASP2 in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Upregulated miRNA-182-5p expression in tumor tissue and peripheral blood samples from patients with non-small cell lung cancer is associated with downregulated Caspase 2 expression.
Carcinoma, Ovarian Epithelial
Inhibition of microRNA-383 has tumor suppressive effect in human epithelial ovarian cancer through the action on caspase-2 gene.
Carcinoma, Renal Cell
PIDDosome expression and the role of caspase-2 activation for chemotherapy-induced apoptosis in RCCs.
Cardiotoxicity
Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death with the apoptotic component blunted by both caspase-2 and caspase-3 inhibitors.
caspase-2 deficiency
Caspase-2 deficiency accelerates chemically induced liver cancer in mice.
caspase-2 deficiency
Caspase-2 deficiency enhances aging-related traits in mice.
caspase-2 deficiency
Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity.
caspase-2 deficiency
Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function.
caspase-2 deficiency
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.
caspase-2 deficiency
Caspase-2 deficiency protects mice from diabetes-induced marrow adiposity.
caspase-2 deficiency
Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3? signaling.
caspase-2 deficiency
Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.
caspase-2 deficiency
Caspase-2 protects against oxidative stress in vivo.
caspase-2 deficiency
Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.
caspase-2 deficiency
Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.
caspase-2 deficiency
Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.
caspase-2 deficiency
Transcriptome profiling of caspase-2 deficient E?Myc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.
caspase-2 deficiency
Tumor-suppressing function of caspase-2 requires catalytic site C320 and site S139 in mice.
Cholangiocarcinoma
Tamoxifen enhances therapeutic effects of gemcitabine on cholangiocarcinoma tumorigenesis.
Colonic Neoplasms
Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol.
Colonic Neoplasms
Caspase-4 is essential for saikosaponin a-induced apoptosis acting upstream of caspase-2 and ?-H2AX in colon cancer cells.
Colonic Neoplasms
Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis.
Colonic Neoplasms
MiR-125a-5p decreases after long non-coding RNA HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2.
Colonic Neoplasms
Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells.
Colonic Neoplasms
Simulated colon fiber metabolome regulates genes involved in cell cycle, apoptosis, and energy metabolism in human colon cancer cells.
Colonic Neoplasms
Zingiberene inhibits in vitro and in vivo human colon cancer cell growth via autophagy induction, suppression of PI3K/AKT/mTOR Pathway and caspase 2 deactivation.
Colorectal Neoplasms
BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer.
Colorectal Neoplasms
CAT25 defines microsatellite instability in colorectal cancer by high-resolution melting PCR.
Colorectal Neoplasms
Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential.
Colorectal Neoplasms
Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?
Colorectal Neoplasms
Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2.
Colorectal Neoplasms
Somatic mutations of caspase-2 gene in gastric and colorectal cancers.
Colorectal Neoplasms
T25 repeat in the 3' untranslated region of the CASP2 gene: a sensitive and specific marker for microsatellite instability in colorectal cancer.
Dementia
A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease.
Dementia
A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals.
Dementia
THD-Module Extractor: An Application for CEN Module Extraction and Interesting Gene Identification for Alzheimer's Disease.
Down Syndrome
Trisomy 21 is Associated with Caspase-2 Upregulation in Cytotrophoblasts at the Maternal-Fetal Interface.
Dysgeusia
Gustatory innervation and bax-dependent caspase-2: participants in the life and death pathways of mouse taste receptor cells.
Epilepsy
Increased expression of caspase 2 in experimental and human temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Increased expression of caspase 2 in experimental and human temporal lobe epilepsy.
Fatty Liver
ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.
Fatty Liver
Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.
Fatty Liver
Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on caspase-2 signaling inhibition.
Fibrosarcoma
PIDDosome-independent tumor suppression by Caspase-2.
Frontotemporal Dementia
A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease.
Glaucoma
Pharmacological inhibition of caspase-2 protects axotomised retinal ganglion cells from apoptosis in adult rats.
Glaucoma
Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection.
Glioblastoma
Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain.
Glioma
microRNA-149 targets caspase-2 in glioma progression.
Glucose Intolerance
Old and Novel Functions of Caspase-2.
Heart Failure
Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of beta-adrenergic and caspase-2 pathways.
Hematologic Neoplasms
Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice.
Hepatitis
The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market.
Hepatitis C
[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]
Huntington Disease
A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients.
Huntington Disease
Increased caspase-2, calpain activations and decreased mitochondrial complex II activity in cells expressing exogenous huntingtin exon 1 containing CAG repeat in the pathogenic range.
Huntington Disease
Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington Disease.
Immune System Diseases
Transcriptome reveals the important role of metabolic imbalances, immune disorders and apoptosis in the treatment of Procambarus clarkii at super high temperature.
Infections
Apoptosis in cultured cells infected with feline calicivirus.
Infections
Caspase-2 mediated apoptotic and necrotic murine macrophage cell death induced by rough Brucella abortus.
Infections
Caspase-mediated cleavage of the feline calicivirus capsid protein.
Infections
Cloning and expression of the cDNA encoding rat caspase-2.
Infections
HIV induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism.
Infections
Inhibition of apoptosis in Cryptosporidium parvum-infected intestinal epithelial cells is dependent on survivin.
Infections
Intrinsic apoptosis and cytokine induction regulated in human tonsillar epithelial cells infected with enterovirus A71.
Infections
Intrinsic apoptosis and proinflammatory cytokines regulated in human astrocytes infected with enterovirus 71.
Infections
Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation.
Infections
miR-2 contributes to WSSV infection by targeting Caspase 2 in mud crab (Scylla paramamosain).
Infections
Next-Generation Sequencing Analysis Reveals Differential Expression Profiles of MiRNA-mRNA Target Pairs in KSHV-Infected Cells.
Infections
Old and Novel Functions of Caspase-2.
Infections
Reactivation of Nedd-2, a developmentally down-regulated apoptotic gene, in apoptosis induced by a street strain of rabies virus.
Infections
The IRE1? Stress Signaling Axis Is a Key Regulator of Neutrophil Antimicrobial Effector Function.
Infections
[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]
Insulin Resistance
Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease.
Insulin Resistance
Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice.
Intellectual Disability
Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability.
Leukemia
Apoptosis-inducing active components from Corbicula fluminea through activation of caspase-2 and production of reactive oxygen species in human leukemia HL-60 cells.
Leukemia
Association of caspase-2 with the promyelocytic leukemia protein nuclear bodies.
Leukemia
BMP4 is Involved in the Chemoresistance of Myeloid Leukemia Cells Through Regulating Autophagy-Apoptosis Balance.
Leukemia
Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines.
Leukemia
Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac).
Leukemia
Next-Generation Sequencing Analysis Reveals Differential Expression Profiles of MiRNA-mRNA Target Pairs in KSHV-Infected Cells.
Leukemia
Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt.
Leukemia
Somatic mutation of proapoptotic caspase-2 gene is rare in acute leukemias and common solid cancers.
Leukemia, Lymphoid
Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lymphocytic leukemia cells.
Leukemia, Myeloid, Acute
Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia.
Leukemia, Myeloid, Acute
Caspase 2 and caspase 3 protein levels as predictors of survival in acute myelogenous leukemia.
Leukemia, Myeloid, Acute
The clinical significance of caspase regulation in acute leukemia.
Leukemia, T-Cell
Induction of caspase-2 gene expression in carboxyl-functionalized carbon nanotube-treated human T-cell leukemia (Jurkat) cell line.
Lewy Body Disease
A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease.
Lichen Planus, Oral
Metallothionein, a marker of antiapoptosis, is associated with clinical forms of oral lichen planus.
Liver Cirrhosis
Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.
Liver Diseases
Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.
Liver Diseases
ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.
Liver Diseases
Old and Novel Functions of Caspase-2.
Liver Diseases, Alcoholic
Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak.
Liver Neoplasms
Caspase-2 deficiency accelerates chemically induced liver cancer in mice.
Lung Neoplasms
A synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), triggers reactive oxygen species-induced apoptosis independently of p53 in A549 lung cancer cells.
Lung Neoplasms
Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.
Lung Neoplasms
Lung cancer cells and their sensitivity/resistance to cisplatin chemotherapy: Role of microRNAs and upstream mediators.
Lung Neoplasms
MiR-494 acts as a tumor promoter by targeting CASP2 in non-small cell lung cancer.
Lung Neoplasms
Upregulated miRNA-182-5p expression in tumor tissue and peripheral blood samples from patients with non-small cell lung cancer is associated with downregulated Caspase 2 expression.
Lymphoma
A tumor suppressor function for caspase-2.
Lymphoma
An unexpected role for caspase-2 in neuroblastoma.
Lymphoma
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.
Lymphoma
CpG oligodeoxynucleotide 5mer-induced apoptosis in MOLT-4 leukaemia cells does not require caspase 3 or new protein synthesis.
Lymphoma
PIDDosome-independent tumor suppression by Caspase-2.
Lymphoma
The engine driving the ship: metabolic steering of cell proliferation and death.
Lymphoma
The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.
Lymphoma
Transcriptome profiling of caspase-2 deficient E?Myc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.
Lymphoma, B-Cell
Induced cell death pathway post photodynamic therapy using a metallophthalocyanine photosensitizer in breast cancer cells.
Lymphoma, B-Cell
Porin Expression Profiles in Haemaphysalis longicornis Infected With Babesia microti.
Lymphoma, B-Cell
The engine driving the ship: metabolic steering of cell proliferation and death.
Lymphoma, B-Cell, Marginal Zone
CpG oligodeoxynucleotide 5mer-induced apoptosis in MOLT-4 leukaemia cells does not require caspase 3 or new protein synthesis.
Lymphopenia
Mapping of caspase-2 in the rat and its exclusion as a candidate gene for lymphopenia.
Melanoma
Camptothecin induces p53-dependent and -independent apoptogenic signaling in melanoma cells.
Melanoma
Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2.
Melanoma
H1 histamine receptor antagonists induce genotoxic and caspase-2-dependent apoptosis in human melanoma cells.
Melanoma
Increased Caspase-2 Activity is Associated With Induction of Apoptosis in IFN-beta Sensitive Melanoma Cell Lines.
Melanoma
NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma.
Memory Disorders
Caspase-2 cleavage of tau reversibly impairs memory.
Memory Disorders
Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3? signaling.
Metabolic Syndrome
Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.
Mouth Neoplasms
Soy protein extract (SPE) exhibits differential in vitro cell proliferation effects in oral cancer and normal cell lines.
Multiple Myeloma
Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells.
Neoplasm Metastasis
c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.
Neoplasm Metastasis
Effect of homeopathic treatment on gene expression in Copenhagen rat tumor tissues.
Neoplasms
5-Phenylselenyl- and 5-methylselenyl-methyl-2'-deoxyuridine induce oxidative stress, DNA damage, and caspase-2-dependent apoptosis in cancer cells.
Neoplasms
A caspase-2-RFXANK interaction and its implication for MHC class II expression.
Neoplasms
A nonapoptotic role for CASP2/caspase 2: modulation of autophagy.
Neoplasms
A tumor suppressor function for caspase-2.
Neoplasms
Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
Neoplasms
Altered Expression of Signaling Genes in Jurkat Cells upon FTY720 Induced Apoptosis.
Neoplasms
An unexpected role for caspase-2 in neuroblastoma.
Neoplasms
Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die.
Neoplasms
Apoptosis is signalled early by low doses of ionising radiation in a radiation-induced bystander effect.
Neoplasms
Apoptosis protease activator protein-1 expression is dispensable for response of human melanoma cells to distinct proapoptotic agents.
Neoplasms
Apoptotic and Immunosuppressive Effects of Turmeric Paste on 7, 12 Di Methyl Benz (a) Anthracene Induced Skin Tumor Model of Wistar Rat.
Neoplasms
BCL9L Dysfunction Promotes Aneuploidy Tolerance in Colon Tumors.
Neoplasms
Beta-carotene: a colorful killer of cancer cells? A commentary on "ROS-triggered caspase 2 activation and feedback amplification loop in beta-carotene-induced apoptosis".
Neoplasms
Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis.
Neoplasms
c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis.
Neoplasms
Cardiac glycoside-induced cell death and Rho/Rho kinase pathway: Implication of different regulation in cancer cell lines.
Neoplasms
Caspase 2 and p53 Reunited in Tumor Control.
Neoplasms
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
Neoplasms
Caspase 2-mediated tumor suppression involves survivin gene silencing.
Neoplasms
Caspase-2 activation is redundant during seizure-induced neuronal death.
Neoplasms
Caspase-2 and oxidative stress underlie the immunogenic potential of high hydrostatic pressure-induced cancer cell death.
Neoplasms
Caspase-2 as a tumour suppressor.
Neoplasms
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.
Neoplasms
Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.
Neoplasms
Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8.
Neoplasms
Caspase-2 protects against oxidative stress in vivo.
Neoplasms
Caspase-2 protocols.
Neoplasms
Caspase-2 regulates oncogene-induced senescence.
Neoplasms
Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond.
Neoplasms
Caspase-2-mediated cell death is required for deleting aneuploid cells.
Neoplasms
Caspase-2/NEDD-2 protease mediates execution of apoptosis in AK-5 tumor cells.
Neoplasms
Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment.
Neoplasms
Caspase-2: controversial killer or checkpoint controller?
Neoplasms
Caspase-2: the orphan caspase.
Neoplasms
Caspase-2: the reinvented enzyme.
Neoplasms
Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.
Neoplasms
Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains.
Neoplasms
Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer.
Neoplasms
Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway.
Neoplasms
Dimer-specific immunoprecipitation of active caspase-2 identifies TRAF proteins as novel activators.
Neoplasms
Down-regulated RBM5 inhibits bladder cancer cell apoptosis by initiating an miR-432-5p/?-catenin feedback loop.
Neoplasms
Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.
Neoplasms
Effect of homeopathic treatment on gene expression in Copenhagen rat tumor tissues.
Neoplasms
Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis.
Neoplasms
Establishment of human prostate tumor xenografts in nude mice and response to 9-nitrocamptothecin in vivo and in vitro does not correlate with the expression of various apoptosis-regulating proteins.
Neoplasms
Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G(2)/M checkpoint signaling.
Neoplasms
Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.
Neoplasms
Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice.
Neoplasms
Genotoxic, cytostatic, antineoplastic and apoptotic effects of newly synthesized antitumour steroidal esters.
Neoplasms
High levels of expression and nuclear localization of interleukin-1 beta converting enzyme (ICE) and CPP32 in favorable human neuroblastomas.
Neoplasms
Histone deacetylase inhibitors enhance Ad5-TRAIL killing of TRAIL-resistant prostate tumor cells through increased caspase-2 activity.
Neoplasms
Imbalance of the mitochondrial pro- and anti-apoptotic mediators in neuroblastoma tumours with unfavourable biology.
Neoplasms
Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice.
Neoplasms
Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.
Neoplasms
Importance of transcript levels of caspase-2 isoforms S and L for breast carcinoma progression.
Neoplasms
In situ analysis of Raidd-beta-galactosidase fusion gene expression in transgenic mouse midgestation embryos.
Neoplasms
Indication of participation of caspase-2 and caspase-5 in mechanisms of human cervical malignancy.
Neoplasms
Induction of caspase-2 activation by a DNA enzyme evokes tumor cell apoptosis.
Neoplasms
Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.
Neoplasms
Inhibition of microRNA-383 has tumor suppressive effect in human epithelial ovarian cancer through the action on caspase-2 gene.
Neoplasms
Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer.
Neoplasms
Landfill soil leachates from Nigeria and India induced DNA damage and alterations in genes associated with apoptosis in Jurkat cell.
Neoplasms
Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.
Neoplasms
Melittin induces NSCLC apoptosis via inhibition of miR-183.
Neoplasms
microRNA-149 targets caspase-2 in glioma progression.
Neoplasms
MiR-125a-5p decreases after long non-coding RNA HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2.
Neoplasms
MiR-494 acts as a tumor promoter by targeting CASP2 in non-small cell lung cancer.
Neoplasms
Molecular differentiation of early and late stage laryngeal squamous cell carcinoma: an exploratory analysis.
Neoplasms
Natural agents targeting the alpha7-nicotinic-receptor in NSCLC: a promising prospective in anti-cancer drug development.
Neoplasms
Next-Generation Sequencing Analysis Reveals Differential Expression Profiles of MiRNA-mRNA Target Pairs in KSHV-Infected Cells.
Neoplasms
Old and Novel Functions of Caspase-2.
Neoplasms
Old, new and emerging functions of caspases.
Neoplasms
Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells.
Neoplasms
PIDDosome expression and the role of caspase-2 activation for chemotherapy-induced apoptosis in RCCs.
Neoplasms
PIDDosome-independent tumor suppression by Caspase-2.
Neoplasms
Prefrontal Cortex and Hippocampus Inflammation in Mice Fed High-Carbohydrate or High-Fat Diets.
Neoplasms
Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion.
Neoplasms
Renal sympathetic denervation improves myocardial apoptosis in rats with isoproterenol-induced heart failure by downregulation of tumor necrosis factor-? and nuclear factor-?B.
Neoplasms
Secretory leukoprotease inhibitor inhibits cell growth through apoptotic pathway on ovarian cancer.
Neoplasms
Somatic mutation of proapoptotic caspase-2 gene is rare in acute leukemias and common solid cancers.
Neoplasms
Somatic mutations of caspase-2 gene in gastric and colorectal cancers.
Neoplasms
Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer.
Neoplasms
Structural and enzymatic insights into caspase-2 substrate recognition and catalysis.
Neoplasms
Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD.
Neoplasms
Support for an infection-induced apoptotic pathway in human fetal membranes.
Neoplasms
Tamoxifen enhances therapeutic effects of gemcitabine on cholangiocarcinoma tumorigenesis.
Neoplasms
TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death.
Neoplasms
The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development.
Neoplasms
The Role of Caspase-2 in Regulating Cell Fate.
Neoplasms
The role of caspase-2 in stress-induced apoptosis.
Neoplasms
The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells.
Neoplasms
The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.
Neoplasms
Transcriptome profiling of caspase-2 deficient E?Myc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.
Neoplasms
TRIM16 overexpression induces apoptosis through activation of caspase-2 in cancer cells.
Neoplasms
Triple-threat activity of PEDF in bone tumors: Tumor inhibition, tissue preservation and cardioprotection against doxorubicin.
Neoplasms
Tumor necrosis factor-alpha-induced apoptosis in olfactory epithelium in vitro: possible roles of caspase 1 (ICE), caspase 2 (ICH-1), and caspase 3 (CPP32).
Neoplasms
Tumor-suppressing function of caspase-2 requires catalytic site C320 and site S139 in mice.
Neoplasms
Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5.
Neoplasms
Upregulated miRNA-182-5p expression in tumor tissue and peripheral blood samples from patients with non-small cell lung cancer is associated with downregulated Caspase 2 expression.
Neoplasms
Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis.
Neoplasms
Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death.
Neoplasms
[Caspase-2 as an Oncosupressor and Metabolism Regulator: What Life Will Bring over the Long Run?]
Neoplasms
[Caspase-2: what do we know today?].
Neoplasms, Germ Cell and Embryonal
Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.
Neuroblastoma
An unexpected role for caspase-2 in neuroblastoma.
Neuroblastoma
Ca(2+)-independent caspase-3 but not Ca(2+)-dependent caspase-2 activation induced by oxidative stress leads to SH-SY5Y human neuroblastoma cell apoptosis.
Neuroblastoma
Caspases-2, -3, and -7 are involved in thapsigargin-induced apoptosis of SH-SY5Y neuroblastoma cells.
Neuroblastoma
Inhibition of glycogen synthase kinase-3 protects cells from intrinsic but not extrinsic oxidative stress.
Neuroblastoma
Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe.
Neuroblastoma
Old and Novel Functions of Caspase-2.
Neuroblastoma
Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway.
Neuroblastoma
Transcriptome profiling of caspase-2 deficient E?Myc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.
Neurodegenerative Diseases
Caspase inhibitors: a review of recently patented compounds (2013-2015).
Non-alcoholic Fatty Liver Disease
Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model.
Obesity
Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity.
Obesity
Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.
Optic Nerve Diseases
Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection.
Optic Nerve Injuries
Effects of intravitreal injection of siRNA against caspase-2 on retinal and optic nerve degeneration in air blast induced ocular trauma.
Optic Nerve Injuries
Ocular neuroprotection by siRNA targeting caspase-2.
Optic Nerve Injuries
Old and Novel Functions of Caspase-2.
Optic Neuritis
Pharmacological inhibition of caspase-2 protects axotomised retinal ganglion cells from apoptosis in adult rats.
Optic Neuropathy, Ischemic
Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection.
Optic Neuropathy, Ischemic
[Caspase inhibition: From cellular biology and thanatology to potential clinical agents].
Osteosarcoma
c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.
Osteosarcoma
c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis.
Osteosarcoma
Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.
Ovarian Neoplasms
Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.
Ovarian Neoplasms
Mechanism of caspase-2 activation upon DNA damage.
Pancreatic Neoplasms
The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market.
Pancreatitis
Inflammatory cells regulate p53 and caspases in acute pancreatitis.
Papilloma
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.
Polycystic Kidney, Autosomal Dominant
Pathways of caspase-mediated apoptosis in autosomal-dominant polycystic kidney disease (ADPKD).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The clinical significance of caspase regulation in acute leukemia.
Primary Immunodeficiency Diseases
PIDD-dependent activation of caspase-2-mediated mitochondrial injury in E1A-induced cellular sensitivity to macrophage nitric oxide-induced apoptosis.
Prostatic Neoplasms
Caspase-2-Based Regulation of the Androgen Receptor and Cell Cycle in the Prostate Cancer Cell Line LNCaP.
Prostatic Neoplasms
Chronic administration of valproic acid inhibits prostate cancer cell growth in vitro and in vivo.
Prostatic Neoplasms
Docetaxel loaded oleic acid-coated hydroxyapatite nanoparticles enhance the docetaxel-induced apoptosis through activation of caspase-2 in androgen independent prostate cancer cells.
Prostatic Neoplasms
Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.
Prostatic Neoplasms
Mitotic catastrophe and apoptosis induced by docetaxel in hormone-refractory prostate cancer cells.
Prostatic Neoplasms
Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells.
Prostatic Neoplasms
TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome.
Rabies
BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein.
Rabies
Reactivation of Nedd-2, a developmentally down-regulated apoptotic gene, in apoptosis induced by a street strain of rabies virus.
Reperfusion Injury
Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.
Retinal Degeneration
A sponge transgenic mouse model reveals important roles for the miRNA-183/96/182 cluster in post-mitotic photoreceptors of the retina.
Rhabdomyosarcoma
TRAIL-induced cytotoxicity in a melphalan-resistant rhabdomyosarcoma cell line via activation of caspase-2.
Seizures
Caspase-2 activation is redundant during seizure-induced neuronal death.
Small Cell Lung Carcinoma
Rescue from enhanced alkylator-induced cell death with low molecular weight sulfur-containing chemoprotectants.
Small Cell Lung Carcinoma
TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death.
Stomach Neoplasms
Loss of caspase-2, -6 and -7 expression in gastric cancers.
Stomach Neoplasms
Prognostic significance of mRNA expression of CASPs in gastric cancer.
Stomach Neoplasms
Somatic mutations of caspase-2 gene in gastric and colorectal cancers.
Stroke
miR-1247-3p mediates apoptosis of cerebral neurons by targeting caspase-2 in stroke.
Tauopathies
Caspase-2 cleavage of tau reversibly impairs memory.
Telangiectasis
Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.
Thyroid Cancer, Papillary
Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-2.
Thyroid Neoplasms
Study on the effect of integrin ???6 on the proliferation and apoptosis of thyroid carcinoma cells.
Tuberculosis
Immunogenicity and protective efficacy of a tuberculosis DNA vaccine co-expressing pro-apoptotic caspase-3.
Virus Diseases
miR-2 contributes to WSSV infection by targeting Caspase 2 in mud crab (Scylla paramamosain).
Virus Diseases
[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]
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Wang, L.; Miura M.; Bergeron, L.; Zhu, H.; Yuan, J.
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death
Cell
78
739-750
1994
Homo sapiens (P42575)
brenda
Xue, D.; Shaham, S.; Horvitz, H.R.
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease
Genes Dev.
10
1073-1083
1996
Homo sapiens (P42575)
brenda
Zhivotovsky, B.; Orrenius, S.
Caspase-2 function in response to DNA damage
Biochem. Biophys. Res. Commun.
331
859-867
2005
Homo sapiens (P42575)
brenda
Tyagi, A.; Singh, R.P.; Agarwal, C.; Agarwal, R.
Silibinin activates p53-caspase-2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase-2
Carcinogenesis
27
2269-2280
2006
Homo sapiens (P42575), Homo sapiens
brenda
Shin, S.; Lee, Y.; Kim, W.; Ko, H.; Choi, H.; Kim, K.
Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8
EMBO J.
24
3532-3542
2005
Homo sapiens (P42575)
brenda
Cheung, H.H.; Lynn Kelly, N.; Liston, P.; Korneluk, R.G.
Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: a role for the IAPs
Exp. Cell Res.
312
2347-2357
2006
Homo sapiens (P42575)
brenda
Ho, P.K.; Jabbour, A.M.; Ekert, P.G.; Hawkins, C.J.
Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7
FEBS J.
272
1401-1414
2005
Homo sapiens (P42575), Homo sapiens
brenda
Cristobal, J.; Stockert, J.C.; Villanueva, A.; Rello-Varona, S.; Juarranz, A.; Canete, M.
Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment
Int. J. Oncol.
28
1057-1063
2006
Homo sapiens (P42575)
brenda
Wagner, K.W.; Engels, I.H.; Deveraux, Q.L.
Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway
J. Biol. Chem.
279
35047-35052
2004
Homo sapiens (P42575)
brenda
Enoksson, M.; Robertson, J.D.; Gogvadze, V.; Bu, P.; Kropotov, A.; Zhivotovsky, B.; Orrenius, S.
Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids
J. Biol. Chem.
279
49575-49578
2004
Homo sapiens (P42575)
brenda
Iwanaga, N.; Kamachi, M.; Aratake, K.; Izumi, Y.; Ida, H.; Tanaka, F.; Tamai, M.; Arima, K.; Nakamura, H.; Origuchi, T.; Kawakami, A.; Eguchi, K.
Regulation of alternative splicing of caspase-2 through an intracellular signaling pathway in response to pro-apoptotic stimuli
J. Lab. Clin. Med.
145
105-110
2005
Homo sapiens (P42575)
brenda
Logette, E.; Le Jossic-Corcos, C.; Masson, D.; Solier, S.; Sequeira-Legrand, A.; Dugail, I.; Lemaire-Ewing, S.; Desoche, L.; Solary, E.; Corcos, L.
Caspase-2, a novel lipid sensor under the control of sterol regulatory element binding protein 2
Mol. Cell. Biol.
25
9621-9631
2005
Homo sapiens (P42575), Homo sapiens
brenda
Filomenko, R.; Prvotat, L.; Rb, C.; Cortier, M.; Jeannin, J.F.; Solary, E.; Bettaieb, A.
Caspase-10 involvement in cytotoxic drug-induced apoptosis of tumor cells
Oncogene
2006
1-11
2006
Homo sapiens (P42575)
-
brenda
Kitevska, T.; Spencer, D.M.; Hawkins, C.J.
Caspase-2: controversial killer or checkpoint controller?
Apoptosis
14
829-848
2009
Homo sapiens (P42575)
brenda
Tang, Y.; Wells, J.A.; Arkin, M.R.
Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis
J. Biol. Chem.
286
34147-34154
2011
Homo sapiens (P42575), Homo sapiens
brenda
Vakifahmetoglu-Norberg, H.; Norberg, E.; Perdomo, A.B.; Olsson, M.; Ciccosanti, F.; Orrenius, S.; Fimia, G.M.; Piacentini, M.; Zhivotovsky, B.
Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death
Cell Death Dis.
4
e940
2013
Homo sapiens (P42575)
brenda
Wejda, M.; Impens, F.; Takahashi, N.; Van Damme, P.; Gevaert, K.; Vandenabeele, P.
Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike
J. Biol. Chem.
287
33983-33995
2012
Homo sapiens (P42575), Homo sapiens
brenda
Han, C.; Zhao, R.; Kroger, J.; Qu, M.; Wani, A.A.; Wang, Q.E.
Caspase-2 short isoform interacts with membrane-associated cytoskeleton proteins to inhibit apoptosis
PLoS ONE
8
e67033
2013
Homo sapiens (P42575)
brenda
Terry, M.; Arya, R.; Mukhopadhyay, A.; Berrett, K.; Clair, P.; Witt, B.; Salama, M.; Bhutkar, A.; Oliver, T.
Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo
Cell Death Differ.
22
719-730
2015
Homo sapiens (P42575), Homo sapiens
brenda
Zhao, X.; Kotilinek, L.A.; Smith, B.; Hlynialuk, C.; Zahs, K.; Ramsden, M.; Cleary, J.; Ashe, K.H.
Caspase-2 cleavage of tau reversibly impairs memory
Nat. Med.
22
1268-1276
2016
Mus musculus (P29594), Homo sapiens (P42575), Homo sapiens
brenda
3.4.22.55 caspase-2
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
