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The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
broad endopeptidase specificity
broad endopeptidase activity
Synonyms
capn3, calpain 3, calpain-3, ncl-1, calpain3, muscle calpain, skeletal muscle-specific calpain, muscle-specific calpain, calpain 3 (p94), calpain p94,
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calcium-activated neutral proteinase 3
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muscle-specific calcium-activated neutral protease 3
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Ca2+
dependent on
Ca2+
regulated by Ca2+, contains 2 EF-hand calcium-binding domains. Activated by micromolar concentrations of calcium
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SwissProt
brenda
breeds Brahmna, Belmont REd, Santa Gertrudis
SwissProt
brenda
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papillomavirus-associated urothelial tumors of the urinary bladder
brenda
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brenda
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brenda
in urothelial cancer cells, calpain 3 is observed mostly in the cytoplasm
brenda
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CAN3_BOVIN
822
0
94603
Swiss-Prot
other Location (Reliability: 2)
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M18R
influence on meat tenderness estimated
additional information
DNA mutation 1538+225G>T and DNA mutation 2443-103G>C, influence on meat tenderness estimated
additional information
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DNA mutation 1538+225G>T and DNA mutation 2443-103G>C, influence on meat tenderness estimated
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Bos taurus (P51186), Homo sapiens (P20807), Mus musculus (Q64691), Sus scrofa (P43368)
brenda
Ilian, M.A.; Morton, J.D.; Kent, M.P.; Le Couteur, C.E.; Hickford, J.; Cowley, R.; Bickerstaffe, R.
Intermuscular variation in tenderness: association with the ubiquitous and muscle-specific calpains
J. Anim. Sci.
79
122-132
2001
Bos taurus (P51186), Bos taurus, Ovis aries (Q9TTH8)
brenda
Nonneman, D.; Koohmaraie, M.
Molecular cloning and mapping of the bovine and ovine skeletal muscle-specific calpains
Anim. Genet.
30
456-458
1999
Bos taurus (P51186), Ovis aries (Q9TTH8)
brenda
Barendse, W.; Harrison, B.E.; Bunch, R.J.; Thomas, M.B.
Variation at the Calpain 3 gene is associated with meat tenderness in zebu and composite breeds of cattle
BMC Genet.
9
41
2008
Bos taurus (P51186), Bos taurus
brenda
Roperto, S.; De Tullio, R.; Raso, C.; Stifanese, R.; Russo, V.; Gaspari, M.; Borzacchiello, G.; Averna, M.; Paciello, O.; Cuda, G.; Roperto, F.
Calpain3 is expressed in a proteolitically active form in papillomavirus-associated urothelial tumors of the urinary bladder in cattle
PLoS ONE
5
e10299
2010
Bos taurus (P51186), Bos taurus
brenda
3.4.22.54 calpain-3
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
