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26S proteasome regulatory subunit 6A + H2O
?
-
-
-
?
AHNAK nucleoprotein + H2O
?
AHNAK-N peptide + H2O
?
-
a putative cleavage site is AHNAK-C2.2
-
-
?
ALDOA protein + H2O
?
-
-
-
?
aldolase A + H2O
?
-
not an in vivo substrate or not detectable in total cell extracts
-
-
?
alpha-actinin-3 + H2O
?
-
-
-
-
?
alpha-fodrin + H2O
?
-
-
-
-
?
ANKRD23/CARP/MARP1 protein + H2O
?
-
-
-
?
annexin A1 + H2O
?
-
-
-
?
annexin A2 + H2O
?
-
-
-
?
annexin A7 + H2O
?
-
-
-
?
beta-oxidation enzyme + H2O
?
-
-
-
?
C/EBPa protein + H2O
?
-
-
-
?
calpastatin + H2O
?
-
-
-
-
?
cardiac ankyrin repeat protein + H2O
?
-
-
-
?
CTBP1 protein + H2O
?
i.e. C-terminal binding protein 1
-
-
?
eukaryotic elongation factor 1-alpha 1 + H2O
?
-
-
-
?
eukaryotic elongation factor 1-alpha 2 + H2O
?
-
-
-
?
eukaryotic elongation factor 2 + H2O
?
-
-
-
?
eukaryotic translation initiation factor 3 subunit 7 + H2O
?
-
-
-
?
filamin-A + H2O
?
-
-
-
?
fructose bisphosphatealdolase A + H2O
?
-
-
-
?
glyceraldehyde-3-phosphate dehydrogenase + H2O
?
-
-
-
?
IkappaB protein + H2O
?
-
-
-
?
importin-7 + H2O
?
-
-
-
?
MyoD + H2O
?
-
calpain 3 down-regulates MyoD protein levels
-
-
?
MyoD protein + H2O
?
-
-
-
?
myosin light chain 1 + H2O
?
-
-
-
-
?
p94 + H2O
?
best substrate for p94 is p94 itself
-
-
?
ryanodine receptor + H2O
?
-
-
-
-
?
succinyl-leucine-tyrosine-aminomethylcoumarin + H2O
?
-
-
-
-
?
thioredoxin + H2O
?
-
-
-
?
triosephosphate isomerase + H2O
?
-
-
-
?
tropomyosin + H2O
?
-
-
-
-
?
troponin I + H2O
?
-
-
-
-
?
troponins T + H2O
?
-
-
-
-
?
very long chain acyl-coenzyme A dehydrogenase + H2O
?
-
an in vivo substrate for calpain-3
-
-
?
cyclin A + H2O
additional information
-
AHNAK nucleoprotein + H2O
?
-
-
-
-
?
AHNAK nucleoprotein + H2O
?
-
AHNAK is lost in cells expressing active CAPN3. Conversely, AHNAK accumulates when calpain 3 is defective in skeletal muscle of calpainopathy patients
-
-
?
beta-catenin + H2O
?
-
-
-
-
?
beta-catenin + H2O
?
-
calpain 3 specifically controls the level of membrane-associated beta-catenin and M-cadherin during myogenesis
-
-
?
connectin + H2O
?
p94 binds to connectin at multiple sites including loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. Dynamic nature of connectin molecule as a regulatory scaffold of p94 functions
-
-
?
connectin + H2O
?
p94 binds to connectin at multiple sites including loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. Dynamic nature of connectin molecule as a regulatory scaffold of p94 functions
-
-
?
cyclin A + H2O
?
-
-
-
-
?
cyclin A + H2O
?
-
-
-
-
?
ezrin + H2O
?
-
-
-
-
?
filamin C + H2O
?
-
-
-
-
?
filamin C + H2O
?
-
-
-
?
filamin C + H2O
?
-
enzyme specifically cleaves the C-terminal portion
-
-
?
filamin C + H2O
?
-
enzyme specifically cleaves the C-terminal portion in living cells. Filamin C may be an in vivo substrate to c3, functioning to regulate protein-protein interactions with the sarcoglycans
-
-
?
filamin C + H2O
?
-
enzyme specifically cleaves the C-terminal portion
-
-
?
filamin C + H2O
?
-
enzyme specifically cleaves the C-terminal portion in living cells. Filamin C may be an in vivo substrate to c3, functioning to regulate protein-protein interactions with the sarcoglycans
-
-
?
M-cadherin + H2O
?
-
-
-
-
?
M-cadherin + H2O
?
-
calpain 3 specifically controls the level of membrane-associated beta-catenin and M-cadherin during myogenesis
-
-
?
MARP2/Ankrd2 + H2O
?
-
-
-
?
MARP2/Ankrd2 + H2O
?
-
-
-
?
talin + H2O
?
-
-
-
-
?
titin + H2O
?
-
-
-
?
titin + H2O
?
the enzyme binds the C-terminus of titin at recognition motifs [LIMV]X(3,4) [LIMV]X(2)[LIMV][DE] and [LIMV]X(3,4)[LIMVA]X(2)[LIMV][DE]
-
-
?
titin + H2O
?
-
calpain 3 expression is required for normal myofibril formation. Calpain 3 may influence the role of titin in sarcomere formation through proteolytic cleavage. The limb girdle muscular dystrophy 2A mutations in calpain C3 influence binding of calpain C3 to titin
-
-
?
titin + H2O
?
the enzyme binds the C-terminus of titin at recognition motifs [LIMV]X(3,4) [LIMV]X(2)[LIMV][DE] and [LIMV]X(3,4)[LIMVA]X(2)[LIMV][DE]
-
-
?
vinexin + H2O
?
-
-
-
-
?
cyclin A + H2O
additional information
-
-
calpain 3-mediated cleavage of cyclin A in dividing myeloid pregenitor cells is important for the onset of differentiation
production of a truncated product that lacks the N-terminal destruction box required for its degradation at the end of mitosis. The cleaved form of cyclin A retains the cyclin-dependent kinase binding domain and forms active complexes with cdk2
?
cyclin A + H2O
additional information
-
-
calpain 3-mediated cleavage of cyclin A in dividing myeloid pregenitor cells is important for the onset of differentiation
production of a truncated product that lacks the N-terminal destruction box required for its degradation at the end of mitosis. The cleaved form of cyclin A retains the cyclin-dependent kinase binding domain and forms active complexes with cdk2
?
additional information
?
-
a small in-frame deletion within the protease domain of muscle-specific calpain, p94 causes early-onset limb-girdle muscular dystrophy 2A
-
-
?
additional information
?
-
mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A
-
-
?
additional information
?
-
mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A
-
-
?
additional information
?
-
-
mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A
-
-
?
additional information
?
-
-
limb-girdle muscular dystrophy type 2A is an autosomal recessive disorder characterized by selective atrophy of the proximal limb muscles. Its occurence is correlated, in a large number of patients, with defects ihn the human CAP3 gene. The most calpain 3 missense mutations are clustered in three areas that appear to affect intramolecular domain interactions and may impair the assembly and activation of this multi-domain protein
-
-
?
additional information
?
-
muscular dystrophy caused by mutations in CANP3 is found in patients from all countries examined so far
-
-
?
additional information
?
-
-
muscular dystrophy caused by mutations in CANP3 is found in patients from all countries examined so far
-
-
?
additional information
?
-
two siblings originating from Reunion Island are affected by a limb-girdle muscular dystrophy type 2A and carry the same two mutations in the calpain gene: 946-1 AGtoAA, affecting a splice site, and S744G. They demonstrate the clinical variability possible with calpain-3 mutations
-
-
?
additional information
?
-
autosomal recessive limb girdle muscular dystrophy is a clinically and genetically heterogenous group of diseases involving at least six different loci. Five genes have already been identified: calpain-3 at LGMD2A (15q15), and four members of the sarcoglycan (SG) complex, alpha-SG at LGMD2D (17q21), beta-SG at LGMD2E (4q12), gamma-SG at LGMD2C (13q12), and delta-SG at LGMD2F (5q33-q34). The gene product at LGMD2B (2p13-p16) is still unknown and at least one other gene is still unmapped
-
-
?
additional information
?
-
-
autosomal recessive limb girdle muscular dystrophy is a clinically and genetically heterogenous group of diseases involving at least six different loci. Five genes have already been identified: calpain-3 at LGMD2A (15q15), and four members of the sarcoglycan (SG) complex, alpha-SG at LGMD2D (17q21), beta-SG at LGMD2E (4q12), gamma-SG at LGMD2C (13q12), and delta-SG at LGMD2F (5q33-q34). The gene product at LGMD2B (2p13-p16) is still unknown and at least one other gene is still unmapped
-
-
?
additional information
?
-
limb-girdle muscular dystrophy: epidemiological study in Guipuzcoa, a small mountainous Basque province in northern Spain, finds the highest prevalence rate of LGMD described so far, 69 per million. Genetic studies demonstrate that 38 cases corresponde to the LGMD2A type, due to calpain-3 gene mutations. The particular calpain-3 mutation predominant in Basque chromosomes, exon 22, 2362AGtoTCATCT, has only been rarely found in the rest of the world. The clinical characteristics of the patients with calpain-3 gene mutations. The disease onset is between the ages of 8 and 15 years, in most cases in the pelvic girdle, and the patients become wheelchair-bound between 11 and 28 years after onset
-
-
?
additional information
?
-
limb-girdle muscular dystrophy type 2A is an autosomal recessive disorder characterized mainly by symmetrical and selective atrophy of the proximal limb muscles. It derives from defects in the human CAPN3 gene. 97 distinct pathogenic calpain 3 mutations have been identified. The mutations are distributed along the entire length of the CAPN3 gene
-
-
?
additional information
?
-
-
limb-girdle muscular dystrophy type 2A is an autosomal recessive disorder characterized mainly by symmetrical and selective atrophy of the proximal limb muscles. It derives from defects in the human CAPN3 gene. 97 distinct pathogenic calpain 3 mutations have been identified. The mutations are distributed along the entire length of the CAPN3 gene
-
-
?
additional information
?
-
-
the selective distribution of the enzyme in T-lymphocytes, B-lymphocytes and natural killer cells , might be related to a specific function of this protease isoform in cells involved in the immune response
-
-
?
additional information
?
-
-
loss-of-function mutations in the calpain 3 gene are associated with limb-girdle muscular dystrophy type 2A. Through the absence of cleavage of the cytoskeletal proteins, calpain 3 deficiency leads to abnormal sarcomers, impairment of muscle contractile capacity and death of muscle fibers
-
-
?
additional information
?
-
-
cytoskeletal proteins are one class of its substrates
-
-
?
additional information
?
-
-
NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3
-
-
?
additional information
?
-
p94 is involved in regulation of the eukaryote protein synthesis system
-
-
?
additional information
?
-
p94 proteolytic activity is involved in responses to muscle conditions, p94 inactivation causes limb-girdle muscular dystrophy
-
-
?
additional information
?
-
-
calpain 3 does not cleave PIAS4
-
-
?
additional information
?
-
the enzyme is associated with limb-girdle muscular dystrophy 2A
-
-
?
additional information
?
-
-
important protein for normal muscle function. Mutations in the c3 gene result in limb-girdle muscular dystrophy type 2A
-
-
?
additional information
?
-
-
calpain 3/p94 is not involved in postmortem proteolysis
-
-
?
additional information
?
-
-
neither the reduction of calpain 3 nor its aberrant activity is responsible for the muscular dystrophy with myositis (mdm). Overexpression of calpain 3 exacerbates muscular dystrophy with myositis (mdm)
-
-
?
additional information
?
-
-
skeletal muscle-specific calpain participates in the regulation of the conventional calpain-calpastatin system in skeletal muscle
-
-
?
additional information
?
-
p94 proteolytic activity is involved in responses to muscle conditions, p94 inactivation causes limb-girdle muscular dystrophy
-
-
?
additional information
?
-
-
calpain-3 does not cleave acetyl-coenzyme A acyltransferase, carnitine O-palmitoyl transferase II, carnitine acetyltransferase, and trifunctional protein alpha subunit
-
-
?
additional information
?
-
-
important protein for normal muscle function. Mutations in the c3 gene result in limb-girdle muscular dystrophy type 2A
-
-
?
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (P20807), Sus scrofa (P43368), Bos taurus (P51186), Mus musculus (Q64691)
brenda
Nakajima, T.; Fukiage, C.; Azuma, M.; Ma, H.; Shearer, T.R.
Different expression patterns for ubiquitous calpains and Capn3 splice variants in monkey ocular tissues
Biochim. Biophys. Acta
1519
55-64
2001
Macaca fascicularis (Q9GLG7), Macaca fascicularis
brenda
Ilian, M.A.; Morton, J.D.; Kent, M.P.; Le Couteur, C.E.; Hickford, J.; Cowley, R.; Bickerstaffe, R.
Intermuscular variation in tenderness: association with the ubiquitous and muscle-specific calpains
J. Anim. Sci.
79
122-132
2001
Bos taurus (P51186), Bos taurus, Ovis aries (Q9TTH8)
brenda
Strausberg R.L.; Feingold E.A.; Grouse L.H.; Derge J.G.; et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Proc. Natl. Acad. Sci. USA
99
16899-16903
2002
Homo sapiens (P20807)
brenda
Sorimachi H.; Tsukahara T.; Okada-Ban M.; Sugita H.; Ishiura S.; Suzuki K.
Identification of a third ubiquitous calpain species - chicken muscle expresses four distinct calpains
Biochim. Biophys. Acta
1261
381-393
1995
Gallus gallus (Q92177)
brenda
Sorimachi H.; Imajoh-Ohmi S.; Emori Y.; Kawasaki H.; Ohno S.; Minami Y.; Suzuki K.
Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle
J. Biol. Chem.
264
20106-20111
1989
Rattus norvegicus (P16259), Homo sapiens (P20807)
brenda
Briley G.P.; Riggs P.K.; Womack, J.E.; Hancock, D.L.; Bidwell, C.A.
Chromosomal localization of the porcine skeletal muscle calpain gene
Mamm. Genome
7
226-228
1996
Sus scrofa (P43368), Sus scrofa
brenda
Richard, I.; Brenguier, L.; Dincer P.; et al.
Multiple independent molecular etiology for limb-girdle muscular dystrophy type 2A patients from various geographical origins
Am. J. Hum. Genet.
60
1128-1138
1997
Homo sapiens (P20807), Homo sapiens, Sus scrofa (P43368)
brenda
Richard, I.; Roudaut, C.; Saenz, A.; Pogue, R.; et al.
Calpainopathy - a survey of mutations and polymorphisms
Am. J. Hum. Genet.
64
1524-1540
1999
Homo sapiens (P20807), Homo sapiens
brenda
Fardeau, M.; Hillaire, D.; Mignard, C.; Feingold, N.; Feingold, J.; Mignard, D.; de Ubeda, B.; Collin, H.; Tome, F.M.S.; Richard, I.; Beckmann J.S.
Juvenile limb-girdle muscular dystrophy. Clinical, histopathological and genetic data from a small community living in the Reunion island
Brain
119
295-308
1996
Homo sapiens (P20807)
-
brenda
Richard, I.; Broux, O.; Allamand, V.; et al.
Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A
Cell
81
27-40
1995
Homo sapiens (P20807), Homo sapiens
brenda
Dincer, P.; Leturcq, F.; Richard, I.; et.al.
A biochemical, genetic, and clinical survey of autosomal recessive limb girdle muscular dystrophies in Turkey
Ann. Neurol.
42
222-229
1997
Homo sapiens (P20807), Homo sapiens
brenda
Urtasun, M.; Saenz, A.; Roudaut, C.; et al.
Limb-girdle muscular dystrophy in Guipuzcoa (Basque Country, Spain)
Brain
121
1735-1747
1998
Homo sapiens (P20807)
-
brenda
Haeffner, K.; Speer, A.; Huebner, C.; Voit, T.; Oexle, K.
A small in-frame deletion within the protease domain of muscle-specific calpain, p94 causes early-onset limb-girdle muscular dystrophy 2A
Hum. Mutat.
1
S298-S300
1998
Homo sapiens (P20807)
-
brenda
Penisson-Besnier, I.; Richard, I.; Dubas, F.; Beckmann, J.S.; Fardeau, M.
Pseudometabolic expression and phenotypic variability of calpain deficiency in two siblings
Muscle Nerve
21
1078-1080
1998
Homo sapiens (P20807)
brenda
Kawai, H.; Akaike, M.; Kunishige, M.; et al.
Clinical, pathological, and genetic features of limb-girdle muscular dystrophy type 2A with new calpain 3 gene mutations in seven patients from three Japanese families
Muscle Nerve
21
1493-1501
1998
Homo sapiens (P20807), Homo sapiens
brenda
Nonneman, D.; Koohmaraie, M.
Molecular cloning and mapping of the bovine and ovine skeletal muscle-specific calpains
Anim. Genet.
30
456-458
1999
Bos taurus (P51186), Ovis aries (Q9TTH8)
brenda
de Tullio, R.; Stifanese, R.; Salamino, F.; Pontremoli, S.; Melloni, E.
Characterization of a new p94-like calpain form in human lymphocytes
Biochem. J.
375
689-696
2003
Homo sapiens
brenda
Guyon, J.R.; Kudryashova, E.; Potts, A.; Dalkilic, I.; Brosius, M.A.; Thompson, T.G.; Beckmann, J.S.; Kunkel, L.M.; Spencer, M.J.
Calpain 3 cleaves filamin C and regulates its ability to interact with gamma- and delta-sarcoglycans
Muscle Nerve
28
472-483
2003
Mus musculus, Rattus norvegicus
brenda
Jia, Z.; Petrounevitch, V.; Wong, A.; Moldoveanu, T.; Davies, P.L.; Elce, J.S.; Beckmann, J.S.
Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain
Biophys. J.
80
2590-2596
2001
Homo sapiens
brenda
Rey, M.A.; Davies, P.L.
The protease core of the muscle-specific calpain, p94, undergoes Ca2+-dependent intramolecular autolysis
FEBS Lett.
532
401-406
2002
Homo sapiens
brenda
Sorimachi, H.; Saido, T.C.; Suzuki, K.
New era of calpain research. Discovery of tissue-specific calpains
FEBS Lett.
343
1-5
1994
Gallus gallus, Homo sapiens, Rattus norvegicus
brenda
Welm, A.L.; Timchenko, N.A.; Ono, Y.; Sorimachi, H.; Radomska, H.S.; Tenen, D.G.; Lekstrom-Himes, J.; Darlington, G.J.
C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells
J. Biol. Chem.
277
33848-33856
2002
Homo sapiens, Mus musculus
brenda
Richard, I.; Beckmann, J.S.
Molecular cloning of mouse canp3, the gene associated with limb-girdle muscular dystrophy 2A in human
Mamm. Genome
7
377-379
1996
Mus musculus (Q64691)
brenda
Murphy, R.M.; Snow, R.J.; Lamb, G.D.
m-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans
Am. J. Physiol.
290
C116-C122
2006
Homo sapiens, Rattus norvegicus
brenda
Ravulapalli, R.; Diaz, B.G.; Campbell, R.L.; Davies, P.L.
Homodimerization of calpain 3 penta-EF-hand domain
Biochem. J.
388
585-591
2005
Homo sapiens (P20807)
brenda
Garcia Diaz, B.E.; Gauthier, S.; Davies, P.L.
Ca2+ dependency of calpain 3 (p84) activation
Biochemistry
45
3714-3722
2006
Homo sapiens
brenda
Saenz, A.; Leturcq, F.; et.al.
LGMD2A: genotype-phenotype correlations based on a large mutational survey on the calpain 3 gene
Brain
128
732-742
2005
Homo sapiens
brenda
Duguez, S.; Bartoli, M.; Richard, I.
Calpain 3: a key regulator of the sarcomere?
FEBS J.
273
3427-3436
2006
Homo sapiens
brenda
Kramerova, I.; Kudryashova, E.; Tidball, J.G.; Spencer, M.J.
Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro
Hum. Mol. Genet.
13
1373-1388
2004
Mus musculus
brenda
Kramerova, I.; Kudryashova, E.; Venkatraman, G.; Spencer, M.J.
Calpain 3 participates in sarcomere remodeling by acting upstream of the ubiquitin-proteasome pathway
Hum. Mol. Genet.
14
2125-2134
2005
Mus musculus
brenda
Huebsch, K.A.; Kudryashova, E.; et.al.
Mdm muscular dystrophy: interactions with calpain 3 and a novel functional role for titin's N2A domain
Hum. Mol. Genet.
14
2801-2811
2005
Mus musculus
brenda
Geesink, G.H.; Taylor, R.G.; Koohmaraie, M.
Calpain 3/p94 is not involved in postmortem proteolysis
J. Anim. Sci.
83
1646-1652
2005
Mus musculus
brenda
Ono, Y.; Kakinuma, K.; Torii, F.; Irie, A.; Nakagawa, K.; Labeit, S.; Abe, K.; Suzuki, K.; Sorimachi, H.
Possible regulation of the conventional calpain system by skeletal muscle-specific calpain, p94/calpain 3
J. Biol. Chem.
279
2761-2771
2004
Mus musculus
brenda
Diaz, B.G.; Moldoveanu, T.; Kuiper, M.J.; Campbell, R.L.; Davies, P.L.
Insertion sequence 1 of muscle-specific calpain p94, acts as an internal propeptide
J. Biol. Chem.
279
27656-27666
2004
Homo sapiens
brenda
Fanin, M.; Nascimbeni, A.C.; Angelini, C.
Screening of calpain-3 autolytic activity in LGMD muscle: a functional map of CAPN3 gene mutations
J. Med. Genet.
44
38-43
2007
Homo sapiens
brenda
Kramerova, I.; Kudryashova, E.; Wu, B.; Spencer, M.J.
Regulation of the M-cadherin-beta-catenin complex by calpain 3 during terminal stages of myogenic differentiation
Mol. Cell. Biol.
26
8437-8447
2006
Mus musculus
brenda
Cohen, N.; Kudryashova, E.; Kramerova, I.; Anderson, L.V.; Beckmann, J.S.; Bushby, K.; Spencer, M.J.
Identification of putative in vivo substrates of calpain 3 by comparative proteomics of overexpressing transgenic and nontransgenic mice
Proteomics
6
6075-6084
2006
Mus musculus
brenda
Norton, L.; Parr, T.; Bardsley, R.G.; Ye, H.; Tsintzas, K.
Characterization of GLUT4 and calpain expression in healthy human skeletal muscle during fasting and refeeding
Acta Physiol. (Oxf.)
189
233-240
2007
Homo sapiens
brenda
Yang, X.; Chen, J.; Xu, Q.; Zhao, R.
Muscle type-specific responses of myoD and calpain 3 expression to recombinant porcine growth hormone in the pig
Animal
1
989-996
2007
Sus scrofa
brenda
Ono, Y.; Hayashi, C.; Doi, N.; Kitamura, F.; Shindo, M.; Kudo, K.; Tsubata, T.; Yanagida, M.; Sorimachi, H.
Comprehensive survey of p94/calpain 3 substrates by comparative proteomics - possible regulation of protein synthesis by p94
Biotechnol. J.
2
565-576
2007
Homo sapiens (P20807)
brenda
Benayoun, B.; Baghdiguian, S.; Lajmanovich, A.; Bartoli, M.; Daniele, N.; Gicquel, E.; Bourg, N.; Raynaud, F.; Pasquier, M.A.; Suel, L.; Lochmuller, H.; Lefranc, G.; Richard, I.
NF-{kappa}B-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A
FASEB J.
22
1521-1529
2007
Homo sapiens
brenda
Huang, Y.; de Morree, A.; van Remoortere, A.; Bushby, K.; Frants, R.R.; den Dunnen, J.; van der Maarel, S.M.
Calpain 3 is a modulator of the dysferlin protein complex in skeletal muscle
Hum. Mol. Genet.
17
1855-1866
2008
Homo sapiens
brenda
Tang, Y.; Liu, X.; Zoltoski, R.K.; Novak, L.A.; Herrera, R.A.; Richard, I.; Kuszak, J.R.; Kumar, N.M.
Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoform
Invest. Ophthalmol. Vis. Sci.
48
2685-2694
2007
Mus musculus
brenda
Murphy, R.M.; Goodman, C.A.; McKenna, M.J.; Bennie, J.; Leikis, M.; Lamb, G.D.
Calpain-3 is autolyzed and hence activated in human skeletal muscle 24 h following a single bout of eccentric exercise
J. Appl. Physiol.
103
926-931
2007
Homo sapiens
brenda
Hayashi, C.; Ono, Y.; Doi, N.; Kitamura, F.; Tagami, M.; Mineki, R.; Arai, T.; Taguchi, H.; Yanagida, M.; Hirner, S.; Labeit, D.; Labeit, S.; Sorimachi, H.
Multiple molecular interactions implicate connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle
J. Biol. Chem.
23
14801-14814
2008
Homo sapiens (P20807), Mus musculus (Q64691)
brenda
Ojima, K.; Ono, Y.; Doi, N.; Yoshioka, K.; Kawabata, Y.; Labeit, S.; Sorimachi, H.
Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain
J. Biol. Chem.
282
14493-14504
2007
Homo sapiens (P20807), Mus musculus (Q64691)
brenda
Garnham, C.; Hanna, R.; Chou, J.; Low, K.; Gourlay, K.; Campbell, R.; Beckmann, J.; Davies, P.
Limb-girdle muscular dystrophy type 2A can result from accelerated autoproteolytic inactivation of calpain 3
Biochemistry
48
3457-3467
2009
Homo sapiens
brenda
Zhang, Z.R.; Liu, Y.P.; Yao, Y.G.; Jiang, X.S.; Du, H.R.; Zhu, Q.
Identification and association of the single nucleotide polymorphisms in calpain3 (CAPN3) gene with carcass traits in chickens
BMC Genet.
10
10
2009
Gallus gallus (Q92177), Gallus gallus
brenda
Barendse, W.; Harrison, B.E.; Bunch, R.J.; Thomas, M.B.
Variation at the Calpain 3 gene is associated with meat tenderness in zebu and composite breeds of cattle
BMC Genet.
9
41
2008
Bos taurus (P51186), Bos taurus
brenda
Vissing, K.; Overgaard, K.; Nedergaard, A.; Fredsted, A.; Schjerling, P.
Effects of concentric and repeated eccentric exercise on muscle damage and calpain-calpastatin gene expression in human skeletal muscle
Eur. J. Appl. Physiol.
103
323-332
2008
Homo sapiens (P20807), Homo sapiens
brenda
Kramerova, I.; Kudryashova, E.; Wu, B.; Ottenheijm, C.; Granzier, H.; Spencer, M.J.
Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle
Hum. Mol. Genet.
17
3271-3280
2008
Mus musculus
brenda
Murphy, R.M.; Lamb, G.D.
Endogenous calpain-3 activation is primarily governed by small increases in resting cytoplasmic [Ca2+] and is not dependent on stretch
J. Biol. Chem.
284
7811-7819
2009
Rattus norvegicus
brenda
Blazquez, L.; Azpitarte, M.; Saenz, A.; Goicoechea, M.; Otaegui, D.; Ferrer, X.; Illa, I.; Gutierrez-Rivas, E.; Vilchez, J.J.; Lopez de Munain, A.
Characterization of novel CAPN3 isoforms in white blood cells: an alternative approach for limb-girdle muscular dystrophy 2A diagnosis
Neurogenetics
9
173-182
2008
Homo sapiens
brenda
Beckmann, J.S.; Spencer, M.
Calpain 3, the "gatekeeper" of proper sarcomere assembly, turnover and maintenance
Neuromuscul. Disord.
18
913-921
2008
Mus musculus
brenda
Mellgren, R.L.; Miyake, K.; Kramerova, I.; Spencer, M.J.; Bourg, N.; Bartoli, M.; Richard, I.; Greer, P.A.; McNeil, P.L.
Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases
Biochim. Biophys. Acta
1793
1886-1893
2009
Mus musculus
brenda
Moretti, D.; Del Bello, B.; Cosci, E.; Biagioli, M.; Miracco, C.; Maellaro, E.
Novel variants of muscle calpain 3 identified in human melanoma cells: cisplatin-induced changes in vitro and differential expression in melanocytic lesions
Carcinogenesis
30
960-967
2009
Homo sapiens
brenda
Ravulapalli, R.; Campbell, R.L.; Gauthier, S.Y.; Dhe-Paganon, S.; Davies, P.L.
Distinguishing between calpain heterodimerization and homodimerization
FEBS J.
276
973-982
2009
Homo sapiens
brenda
Kramerova, I.; Kudryashova, E.; Wu, B.; Germain, S.; Vandenborne, K.; Romain, N.; Haller, R.G.; Verity, M.A.; Spencer, M.J.
Mitochondrial abnormalities, energy deficit and oxidative stress are features of calpain 3 deficiency in skeletal muscle
Hum. Mol. Genet.
18
3194-3205
2009
Mus musculus
brenda
Dayanithi, G.; Richard, I.; Viero, C.; Mazuc, E.; Mallie, S.; Valmier, J.; Bourg, N.; Herasse, M.; Marty, I.; Lefranc, G.; Mangeat, P.; Baghdiguian, S.
Alteration of sarcoplasmic reticulum ca release in skeletal muscle from calpain 3-deficient mice
Int. J. Cell Biol.
2009
340346
2009
Mus musculus
brenda
Mora, L.; Sentandreu, M.A.; Koistinen, K.M.; Fraser, P.D.; Toldra, F.; Bramley, P.M.
Naturally generated small peptides derived from myofibrillar proteins in Serrano dry-cured ham
J. Agric. Food Chem.
57
3228-3234
2009
Sus scrofa
brenda
Stuelsatz, P.; Pouzoulet, F.; Lamarre, Y.; Dargelos, E.; Poussard, S.; Leibovitch, S.; Cottin, P.; Veschambre, P.
Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts
J. Biol. Chem.
285
12670-12683
2010
Mus musculus
brenda
Ono, Y.; Ojima, K.; Torii, F.; Takaya, E.; Doi, N.; Nakagawa, K.; Hata, S.; Abe, K.; Sorimachi, H.
Skeletal muscle-specific calpain is an intracellular Na+-dependent protease
J. Biol. Chem.
285
22986-22998
2010
Rattus norvegicus
brenda
Gornik, S.G.; Westrop, G.D.; Coombs, G.H.; Neil, D.M.
Molecular cloning and localization of a calpain-like protease from the abdominal muscle of Norway lobster Nephrops norvegicus
Mol. Biol. Rep.
37
2009-2019
2010
Nephrops norvegicus
brenda
Charlton, R.; Henderson, M.; Richards, J.; Hudson, J.; Straub, V.; Bushby, K.; Barresi, R.
Immunohistochemical analysis of calpain 3: advantages and limitations in diagnosing LGMD2A
Neuromuscul. Disord.
19
449-457
2009
Homo sapiens
brenda
Laure, L.; Daniele, N.; Suel, L.; Marchand, S.; Aubert, S.; Bourg, N.; Roudaut, C.; Duguez, S.; Bartoli, M.; Richard, I.
A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-?B pathway in skeletal muscle
FEBS J.
277
4322-4337
2010
Homo sapiens (P20807)
brenda
Roperto, S.; De Tullio, R.; Raso, C.; Stifanese, R.; Russo, V.; Gaspari, M.; Borzacchiello, G.; Averna, M.; Paciello, O.; Cuda, G.; Roperto, F.
Calpain3 is expressed in a proteolitically active form in papillomavirus-associated urothelial tumors of the urinary bladder in cattle
PLoS ONE
5
e10299
2010
Bos taurus (P51186), Bos taurus
brenda
de Morree, A.; Lutje Hulsik, D.; Impagliazzo, A.; van Haagen, H.H.; de Galan, P.; van Remoortere, A.; t Hoen, P.A.; van Ommen, G.B.; Frants, R.R.; van der Maarel, S.M.
Calpain 3 is a rapid-action, unidirectional proteolytic switch central to muscle remodeling
PLoS ONE
5
e11940
2010
Homo sapiens
brenda
Charton, K.; Sarparanta, J.; Vihola, A.; Milic, A.; Jonson, P.H.; Suel, L.; Luque, H.; Boumela, I.; Richard, I.; Udd, B.
CAPN3-mediated processing of C-terminal titin replaced by pathological cleavage in titinopathy
Hum. Mol. Genet.
24
3718-3731
2015
Homo sapiens (P20807), Mus musculus (Q64691)
brenda
Ermolova, N.; Kramerova, I.; Spencer, M.J.
Autolytic activation of calpain 3 proteinase is facilitated by calmodulin protein
J. Biol. Chem.
290
996-1004
2015
Mus musculus (Q64691), Mus musculus
brenda
Pistoni, M.; Shiue, L.; Cline, M.S.; Bortolanza, S.; Neguembor, M.V.; Xynos, A.; Ares, M.; Gabellini, D.
Rbfox1 downregulation and altered calpain 3 splicing by FRG1 in a mouse model of facioscapulohumeral muscular dystrophy (FSHD)
PLoS Genet.
9
e1003186
2013
Homo sapiens (P20807), Homo sapiens, Mus musculus (Q64691), Mus musculus
brenda
Kumchantuek, T.; Nakata, H.; Sakulsak, N.; Yamamoto, M.; Iseki, S.
Expression and localization of calpain 3 in the submandibular gland of mice
Arch. Oral Biol.
70
9-15
2016
Mus musculus (Q64691), Mus musculus
brenda
Ono, Y.; Ojima, K.; Shinkai-Ouchi, F.; Hata, S.; Sorimachi, H.
An eccentric calpain, CAPN3/p94/calpain-3
Biochimie
122
169-187
2016
Homo sapiens (P20807), Homo sapiens
brenda
Ono, Y.; Sorimachi, H.
Amino acid sequence alignment of vertebrate CAPN3/calpain-3/p94
Data Brief
5
366-367
2015
Homo sapiens (P20807)
brenda
Ye, Q.; Campbell, R.L.; Davies, P.L.
Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation
J. Biol. Chem.
293
4056-4070
2018
Homo sapiens (P20807), Homo sapiens
brenda
Michel, L.Y.; Hoenderop, J.G.; Bindels, R.J.
Calpain-3-mediated regulation of the Na+-Ca2+ exchanger isoform 3
Pflugers Arch.
468
243-255
2016
Homo sapiens (P20807)
brenda
Moretti, D.; Del Bello, B.; Allavena, G.; Corti, A.; Signorini, C.; Maellaro, E.
Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells
PLoS ONE
10
e0117258
2015
Homo sapiens (P20807), Homo sapiens
brenda