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Information on EC 3.4.22.53 - calpain-2 and Organism(s) Gallus gallus and UniProt Accession Q92178

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.53 calpain-2
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Gallus gallus
UNIPROT: Q92178 not found.
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The taxonomic range for the selected organisms is: Gallus gallus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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broad endopeptidase specificity
Synonyms
m-calpain, calpain ii, calpain-2, calpain 2, calpain2, ncl-2, milli-calpain, mitochondrial m-calpain, calpain-2-like, rat calpain 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
calcium-activated neutral protease II
-
-
-
-
calpain 2
-
-
-
-
calpain II
-
-
-
-
calpain xCL-2 (Xenopus leavis)
-
-
-
-
CAPN2 g.p. (Homo sapiens)
-
-
-
-
m-calpain
-
-
-
-
milli-calpain
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
702693-80-9
-
78990-62-2
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
half-maximal activity at 0.18 mM
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
calpastatin
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
nucleated
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CAN2_CHICK
700
0
79229
Swiss-Prot
Mitochondrion (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
28000
-
1 * 80000 + 1 * 28000, SDS-PAGE
80000
-
1 * 80000 + 1 * 28000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
1 * 80000 + 1 * 28000, SDS-PAGE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
single-step purification of calpain-1, calpain-2, and calpastatin using anion-exchange chromatography
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Murakami, T.; Ueda, M.; Hamakubo, T.; Murachi, T.
Identification of both calpains I and II in nucleated chicken erythrocytes
J. Biochem.
103
168-171
1988
Gallus gallus
Manually annotated by BRENDA team
Sorimachi H.; Tsukahara T.; Okada-Ban M.; Sugita H.; Ishiura S.; Suzuki K.
Identification of a third ubiquitous calpain species - chicken muscle expresses four distinct calpains
Biochim. Biophys. Acta
1261
381-393
1995
Gallus gallus (Q92178)
Manually annotated by BRENDA team
Biswas, A.K.; Tandon, S.
Single-step purification of calpain-1, calpain-2, and calpastatin using anion-exchange chromatography
Methods Mol. Biol.
1915
3-11
2019
Gallus gallus (Q92178)
Manually annotated by BRENDA team