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Information on EC 3.4.22.53 - calpain-2

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.53 calpain-2
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This record set is specific for:
UNIPROT: P04632 not found.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
broad endopeptidase specificity
Synonyms
m-calpain, calpain ii, calpain-2, calpain 2, calpain2, ncl-2, milli-calpain, mitochondrial m-calpain, calpain-2-like, rat calpain 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
calpain 2
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human calpain 2
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calcium-activated neutral protease II
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-
-
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calpain 2
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-
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calpain II
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-
-
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calpain xCL-2 (Xenopus leavis)
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-
-
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CAPN2 g.p. (Homo sapiens)
-
-
-
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m-calpain
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-
-
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milli-calpain
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
702693-80-9
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78990-62-2
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CPNS1_HUMAN
268
0
28316
Swiss-Prot
other Location (Reliability: 5)
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
used as a model for calpain 3 in combination with calpastatin-inhibited rat calpain 2
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Garnham, C.; Hanna, R.; Chou, J.; Low, K.; Gourlay, K.; Campbell, R.; Beckmann, J.; Davies, P.
Limb-girdle muscular dystrophy type 2A can result from accelerated autoproteolytic inactivation of calpain 3
Biochemistry
48
3457-3467
2009
Homo sapiens (P04632), Rattus norvegicus (Q07009)
Manually annotated by BRENDA team