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metabolism
isoform-specific hyperactivation of calpain-2, but not calpain-1 occurs at the synapse early in the pathogenesis of Alzheimer's disease potentially contributing to the deregulation of synaptic signaling in Alzheimer's disease
physiological function
calpain-1 and calpain-2 play opposite roles in retinal ganglion cell death induced by acute intraocular pressure elevation. Calpain-1 activity supports survival of retinal ganglion cell after intraocular pressure elevation. Calpain-2 activity promotes cell death of retinal ganglion cells after intraocular pressure elevation. Calpain-2 activation cleaves striatal-enriched protein tyrosine phosphatase and activates STEP-mediated pro-death pathway in retinal ganglion cells after intraocular pressure elevation
malfunction
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calpain 2 depletion impairs mitosis and induces apoptosis, low Capn2 levels induce chromosome alignment defects, the loss of histone H3 threonine 3 phosphorylation at centromeres, and premature sister chromatid separation
malfunction
-
inhibition of m-calpain induces expression of the adult alpha- and beta-globin genes
malfunction
-
short interfering RNA-induced silencing of m-calpain results in increased RhoA activity and hyperpermeability in the aortic arch, which is accompanied by ROCK inhibitor-sensitive phosphorylation of downstream effecter LIM kinase 2, stress fibre accumulation in endothelium and enhanced interendothelial gaps
malfunction
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calpain 2 knockdown in breast cancer cells correlates with reduced in vitro proliferation, migration, and in vivo tumorigenicity as well as reduced Akt activation, increased nuclear FoxO localization, and increased p27Kip1 expression
malfunction
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calpain inhibition favors differentiation of neuronal stem cells. Calpain 2 silencing elicits decreased levels of glial fibrillary acidic protein
physiological function
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Ca2+ overload induces apoptosis, which was correlated with calpain-2 activation
physiological function
-
calpain 2 is required for sister chromatid cohesion
physiological function
-
m-calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions
physiological function
-
calpain 2 is involved in glial differentiation
physiological function
-
calpain 2 promotes proliferation of cancer cells through Akt-FoxO-p27Kip1 signaling
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Dear T.N.; Matena K.; Vingron M.; Boehm T.
A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution
Genomics
45
175-184
1997
Mus musculus (O08529), Mus musculus
brenda
Glading, A.; Chang, P.; Lauffenburger, D.A.; Wells, A.
Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway
J. Biol. Chem.
275
2390-2398
2000
Mus musculus
brenda
Hata, S.; Koyama, S.; Kawahara, H.; Doi, N.; Maeda, T.; Toyama-Sorimachi, N.; Abe, K.; Suzuki, K.; Sorimachi, H.
Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP
J. Biol. Chem.
281
11214-11224
2006
Mus musculus
brenda
Azuma, M.; Tamada, Y.; Kanaami, S.; Nakajima, E.; Nakamura, Y.; Fukiage, C.; Forsberg, N.E.; Duncan, M.K.; Shearer, T.R.
Differential influence of proteolysis by calpain 2 and Lp82 on in vitro precipitation of mouse lens crystallins
Biochem. Biophys. Res. Commun.
307
558-563
2003
Mus musculus
brenda
Franco, S.; Perrin, B.; Huttenlocher, A.
Isoform specific function of calpain 2 in regulating membrane protrusion
Exp. Cell Res.
299
179-187
2004
Mus musculus
brenda
Reed, N.A.; Castellini, M.A.; Ma, H.; Shearer, T.R.; Duncan, M.K.
Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens
Exp. Eye Res.
76
433-443
2003
Mus musculus
brenda
Shao, H.; Chou, J.; Baty, C.J.; Burke, N.A.; Watkins, S.C.; Stolz, D.B.; Wells, A.
Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation
Mol. Cell. Biol.
26
5481-5496
2006
Mus musculus
brenda
Dutt, P.; Croall, D.E.; Arthur, J.S.; De Veyra, T.; Williams, K.; Elce, J.S.; Greer, P.A.
m-Calpain is required for preimplantation embryonic development in mice
BMC Dev. Biol.
6
3
2006
Mus musculus (O08529), Mus musculus
brenda
Raynaud, F.; Marcilhac, A.; Chebli, K.; Benyamin, Y.; Rossel, M.
Calpain 2 expression pattern and sub-cellular localization during mouse embryogenesis
Int. J. Dev. Biol.
52
383-388
2008
Mus musculus
brenda
Honda, M.; Masui, F.; Kanzawa, N.; Tsuchiya, T.; Toyo-oka, T.
Specific knockdown of m-calpain blocks myogenesis with cDNA deduced from the corresponding RNAi
Am. J. Physiol. Cell Physiol.
294
C957-C965
2008
Mus musculus
brenda
Grossi, A.; Karlsson, A.H.; Lawson, M.A.
Mechanical stimulation of C2C12 cells increases m-calpain expression, focal adhesion plaque protein degradation
Cell Biol. Int.
32
615-622
2008
Mus musculus
brenda
Nakada, S.; Tsuneyama, K.; Kato, I.; Tabuchi, Y.; Takasaki, I.; Furusawa, Y.; Kawaguchi, H.; Fujimoto, M.; Goto, H.; Hikiami, H.; Kondo, T.; Takano, Y.; Shimada, Y.
Identification of candidate genes involved in endogenous protection mechanisms against acute pancreatitis in mice
Biochem. Biophys. Res. Commun.
391
1342-1347
2010
Mus musculus
brenda
Miyazaki, T.; Honda, K.; Ohata, H.
m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions
Cardiovasc. Res.
85
530-541
2010
Mus musculus
brenda
Magnaghi-Jaulin, L.; Marcilhac, A.; Rossel, M.; Jaulin, C.; Benyamin, Y.; Raynaud, F.
Calpain 2 is required for sister chromatid cohesion
Chromosoma
119
267-274
2010
Mus musculus
brenda
Arroba, A.I.; Wallace, D.; Mackey, A.; de la Rosa, E.J.; Cotter, T.G.
IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death
Eur. J. Neurosci.
30
975-986
2009
Mus musculus
brenda
Lin, I.J.; Zhou, Z.; Crusselle-Davis, V.J.; Moghimi, B.; Gandhi, K.; Anantharaman, A.; Pantic, D.; Huang, S.; Jayandharan, G.; Zhong, L.; Srivastava, A.; Bungert, J.
Calpeptin increases the activity of upstream stimulatory factor and induces high level globin gene expression in erythroid cells
J. Biol. Chem.
284
20130-20135
2009
Mus musculus
brenda
Silver, K.; Leloup, L.; Freeman, L.C.; Wells, A.; Lillich, J.D.
Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease
Int. J. Biochem. Cell Biol.
42
2030-2036
2010
Mus musculus
brenda
Ho, W.C.; Pikor, L.; Gao, Y.; Elliott, B.E.; Greer, P.A.
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma
J. Biol. Chem.
287
15458-15465
2012
Mus musculus
brenda
Santos, D.M.; Xavier, J.M.; Morgado, A.L.; Sola, S.; Rodrigues, C.M.
Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation
PLoS ONE
7
e33468
2012
Mus musculus
brenda
Kumchantuek, T.; Nakata, H.; Sakulsak, N.; Yamamoto, M.; Iseki, S.
Expression and localization of calpain 3 in the submandibular gland of mice
Arch. Oral Biol.
70
9-15
2016
Mus musculus (O08529)
brenda
Wang, Y.; Lopez, D.; Davey, P.G.; Cameron, D.J.; Nguyen, K.; Tran, J.; Marquez, E.; Liu, Y.; Bi, X.; Baudry, M.
Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury
Neurobiol. Dis.
93
121-128
2016
Mus musculus (O08529)
brenda
Ahmad, F.; Das, D.; Kommaddi, R.P.; Diwakar, L.; Gowaikar, R.; Rupanagudi, K.V.; Bennett, D.A.; Ravindranath, V.
Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimers disease mice and correlates with memory deficits in human subjects
Sci. Rep.
8
13119
2018
Mus musculus (O08529), Mus musculus
brenda