Reference on EC 3.4.22.52 - calpain-1
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shastri, R.; Anandaraj, M.P.J.S.
A low-calcium-requiring calcium-activated neutral proteinase from human placenta
Biochim. Biophys. Acta
873
260-266
1986
Homo sapiens
Dutt, P.; Springgs, C.N.; Davies, P.L.; Jia, Z.; Elce, J.S.
Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain
Biochem. J.
367
263-269
2002
Rattus norvegicus
Sorimachi, H.; Amano, S.; Ishiura, S.; Suzuki, K.
Primary sequences of rat mu-calpain large and small subunits are, respectively, moderately and highly similar to those of human
Biochim. Biophys. Acta
1309
37-41
1996
Rattus norvegicus (P97571)
Emori, Y.; Kawasaki, H.; Sugihara, H.; Imajoh, S.; Kawashima, S.; Suzuki K.
Isolation and sequence analyses of cDNA clones for the large subunits of two isozymes of rabbit calcium-dependent protease
J. Biol. Chem.
261
9465-9471
1986
Oryctolagus cuniculus (P06815)
Minami, Y.; Emori, Y.; Kawasaki, H.; Suzuki, K.
E-F hand structure-domain of calcium-activated neutral protease (CANP) can bind Ca2+ ions
J. Biochem.
101
889-895
1987
Oryctolagus cuniculus (P06815)
Sun, W.; Ji, S.Q.; Ebert, P.J.; Bidwell, C.A.; Hancock, D.L.
Cloning the partial cDNAs of mu-calpain and m-calpain from porcine skeletal muscle
Biochimie
75
931-936
1993
Sus scrofa (P35750), Sus scrofa
Aoki, K.; Imajoh, S.; Ohno, S.; Emori, Y.; Koike, M.; Kosaki, G.; Suzuki K.
Complete amino acid sequence of the large subunit of the low-Ca2+-requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence
FEBS Lett.
205
313-317
1986
Homo sapiens (P07384), Homo sapiens
Nakajima, T.; Fukiage, C.; Azuma, M.; Ma, H.; Shearer, T.R.
Different expression patterns for ubiquitous calpains and Capn3 splice variants in monkey ocular tissues
Biochim. Biophys. Acta
1519
55-64
2001
Macaca fascicularis (Q9GLG2), Macaca fascicularis
Michetti, M.; Salamino, F.; Minafra, R.; Melloni, E.; Pontremoli, S.
Calcium-binding properties of human erythrocyte calpain
Biochem. J.
325
721-726
1997
Homo sapiens
-
Vilei, E.M.; Calderara, S.; Anagli, J
Berardi, S.; Hitomi, K.; Maki, M: Carafoli, E.: Functional properties of recombinant calpain I and of mutants lacking domains III and IV of the catalytic subunits
J. Biol. Chem.
727
25802-25808
1997
Homo sapiens
-
Murachi, T.; Tanaka, K.; Hatanaka, M.; Murakami, T.
Intracellular cellular Ca2+-dependent protease (calpain) and its high-molecular-weight endogenous inhibitor (calpastatin)
Adv. Enzyme Regul.
19
407-424
1981
Rattus norvegicus
Hitomi, K.; Uchiyama, Y.; Ohkubo, I.; Kunimatsu, M.; Sasaki, M.; Maki, M.
Purification and characterization of the active-site-mutated recombinant human mikro-calpain expressed in baculovirus-infected insect cells
Biochem. Biophys. Res. Commun.
246
681-685
1998
Homo sapiens
Kishimoto, A.; Kajikawa, N.; Tabuchi, H.; Shiota, M.; Nishizuka, Y.
Calcium-dependent neutral proteases, widespread occurence of a species of protease active at lower concentrations of calcium
J. Biochem.
90
889-892
1981
Rattus norvegicus
Penny, I.F.; Taylor, M.A.J.; Harris, A.G.; Etherington, D.J.
Purification and immunological characterization of two calcium-activated neutral proteinases from rabbit skeletal muscle
Biochim. Biophys. Acta
829
244-252
1985
Oryctolagus cuniculus
Fukui, I.; Toyohara, H.; Ito, K.; Hamakubo, T.; Murachi, T.
Molecular and catalytic characterization of intact heterodimeric and derived monomeric calpains isolated under different conditions from pig polymorphonuclear leukocytes
Biochemistry
27
3260-3267
1988
Sus scrofa
Yoshimura, N.; Tsukahara, I.; Murachi, T.
Calpain and calpastatin in porcine retina
Biochem. J.
223
47-51
1984
Sus scrofa
Kitahara, A.; Sasaki, T.; Kikuchi, T.; Yumoto, N.; Yoshimura, N.; Hatanaka, M.; Murachi, T.
Large-scale purification of porcine calpain I and calpain II and comparison of proteolytic fragments of their subunits
J. Biochem.
95
1759-1766
1984
Rattus norvegicus, Sus scrofa
Murachi, T.
Intracellular regulatory system involving calpain and calpastatin
Biochem. Int.
18
263-294
1989
Rattus norvegicus, Sus scrofa
Shastri, R.; Jagadeesh, G.; Anandaraj, M.P.J.S.
Human placental calcium activated neutral proteinase: Separation and functional characterization of subunits
J. Biosci.
15
427-434
1990
Homo sapiens
-
Murakami, T.; Ueda, M.; Hamakubo, T.; Murachi, T.
Identification of both calpains I and II in nucleated chicken erythrocytes
J. Biochem.
103
168-171
1988
Gallus gallus
Yoshimura, N.; Kikuchi, T.; Sasaki, T.; Kithara, A.; Hatanaka, M.; Murachi, T.
Two distinct Ca2+ proteases (calpain I and calpain II) purified concurrently by the same method from rat kidney
J. Biol. Chem.
258
8883-8889
1983
Homo sapiens, Rattus norvegicus
Inomata, M.; Nomoto, M.; Hayashi, M.; Nakamura, M.; Imahori, K.; Kawashima, S.
Comparison of low and high calcium requiring forms of the calcium-activated neutral protease (CANP) from rabbit skeletal muscle
J. Biochem.
95
1661-1670
1984
Oryctolagus cuniculus
Molinari, M.; maki, M.; Carafoli, E.
Purification of mu-calpain by a novel affinity chromatography approach. New insight into the mechanism of the interaction of the protease with targets
J. Biol. Chem.
270
14576-14581
1995
Homo sapiens
Guttmann, R.P.; Baker, D.L.; Seifert, K.M.; Cohen, A.S.; Coulter, D.A.; Lynch, D.R.
Specific proteolysis of the NR2 subunit at multiple sites by calpain
J. Neurochem.
78
1083-1093
2001
Sus scrofa
Diaz, B.G.; Gross, S.; Assfalg-Machleidt, I.; Pfeiler, D.; Gollmitzer, N.; Gabrijelcic-Geiger, D.; Stubbs, M.T.; Fritz, H.; Auerswald, E.A.; Machleidt, W.
Cystatins as calpain inhibitors: engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of m-calpain
Biol. Chem.
382
97-107
2001
Homo sapiens
Shields, D.C.; Schaecher, K.E.; Saido, T.C.; Banik, N.L.
A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain
Proc. Natl. Acad. Sci. USA
96
11486-11491
1999
Homo sapiens
Wolf, B.B.; Goldstein, J.C.; Stennicke, H.R.; Beere, H.; Amarante-Mendes, G.P.; Salvesen, G.S.; Green, D.R.
Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation
Blood
94
1683-1692
1999
Homo sapiens, Sus scrofa
Betts, R.; Weinsheimer, S.; Blouse, G.E.; Anagli, J.
Structural determinants of the calpain inhibitory activity of calpastatin peptide B27-WT
J. Biol. Chem.
278
7800-7809
2003
Sus scrofa
Sloane, J.A.; Hinman, J.D.; Lubonia, M.; Hollander, W.; Abraham, C.R.
Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey
J. Neurochem.
84
157-168
2003
Macaca mulatta
Wang, M.; Sakon, M.; Umeshita, K.; Okuyama, M.; Shiozaki, K.; Nagano, H.; Dohno, K.; Nakamori, S.; Monden, M.
Prednisolone suppresses ischemia-reperfusion injury of the rat liver by reducing cytokine production and calpain m activation
J. Hepatol.
34
278-283
2001
Rattus norvegicus
Tompa, P.; Toth-Boconadi, R.; Friedrich, P.
Frequency decoding of fast calcium oscillations by calpain
Cell Calcium
29
161-170
2001
Homo sapiens
Zhang, J.; Miyamoto, K.I.; Hashioka, S.; Hao, H.P.; Murao, K.; Saido, T.C.; Nakanishi, H.
Activation of m-calpain in developing cortical neurons following methylmercury treatment
Brain Res. Dev. Brain Res.
142
105-110
2003
Rattus norvegicus
Doumit, M.E.; Koohmaraie, M.
Immunoblot analysis of calpastatin degradation: evidence for cleavage by calpain in postmortem muscle
J. Anim. Sci.
77
1467-1473
1999
Bos taurus
Zhang, H.; Yamamoto, Y.; Shumiya, S.; Kunimatsu, M.; Nishi, K.; Ohkubo, I.; Kani, K.
Peptidases play an important role in cataractogenesis: an immunohistochemical study on lenses derived from Shumiya cataract rats
Histochem. J.
33
511-521
2002
Rattus norvegicus
Kulkarni, S.; Goll, D.E.; Fox, J.E.B.
Calpain cleaves RhoA generating a dominant-negative form that inhibits integrin-induced actin filament assembly and cell spreading
J. Biol. Chem.
277
24435-24441
2002
Bos taurus
Ray, S.K.; Wilford, G.G.; Crosby, C.V.; Hogan, E.L.; Banik, N.L.
Diverse stimuli induce calpain overexpression and apoptosis in C6 glioma cells
Brain Res.
829
18-27
1999
Rattus norvegicus
Rojas, F.J.; Brush, M.; Moretti-Rojas, I.
Calpain-calpastatin: a novel, complete calcium-dependent protease system in human spermatozoa
Mol. Hum. Reprod.
5
520-526
1999
Homo sapiens
Ilian, M.A.; Morton, J.D.; Kent, M.P.; Le Couteur, C.E.; Hickford, J.; Cowley, R.; Bickerstaffe, R.
Intermuscular variation in tenderness: association with the ubiquitous and muscle-specific calpains
J. Anim. Sci.
79
122-132
2001
Bos taurus, Ovis aries
Sazontova, T.G.; Matskevich, A.A.; Arkhipenko, Y.V.
Calpains: physiological and pathophysiological significance
Pathophysiology
6
91-102
1999
Rattus norvegicus
-
Wan, W.; DePetrillo, P.B.
Ritonavir inhibition of calcium-activated neutral proteases
Biochem. Pharmacol.
63
1481-1484
2002
Rattus norvegicus
Murphy, R.M.; Snow, R.J.; Lamb, G.D.
m-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans
Am. J. Physiol.
290
C116-C122
2006
Homo sapiens
Veerann, V.; Kaji, T.; Boland, B.; Odrljin, T.; Mohan, P.; Basavarajappa, B.S.; Peterhoff, C.; Cataldo, A.; Rudnicki, A.; Amin, N.; Li, B.S.; Pant, H.C.; Hungund, B.L.; Arancio, O.; Nixon, R.A.
Calpain mediates calcium-induced activation of the Erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: Relevance to Alzheimers disease
Am. J. Pathol.
165
795-805
2004
Homo sapiens
Li, H.; Thompson, V.F.; Goll, D.E.
Effects of autolysis on properties of mu- and m-calpain
Biochim. Biophys. Acta
1691
91-103
2004
Bos taurus
Fernandez-Montalvan, A.; Assfalg-Machleidt, I.; Pfeiler, D.; Fritz, H.; Jochum, M.; Machleidt, W.
mu-Calpain binds to lipid bilayers via the exposed hydrophobic surface of its Ca2+-activated conformation
Biol. Chem.
387
617-627
2006
Homo sapiens
Bihovsky, R.; Tao, M.; Mallamo, J.P.; Wells, G.J.
1,2-Benzothiazine 1,1-dioxide alpha-ketoamide analogues as potent calpain I inhibitors
Bioorg. Med. Chem. Lett.
14
1035-1038
2004
Homo sapiens
Carragher, N.O.
Calpain inhibition: a therapeutic strategy targeting multiple disease states
Curr. Pharm. Des.
12
615-638
2006
Homo sapiens (P07384)
Maddock, K.R.; Huff-Lonergan, E.; Rowe, L.J.; Lonergan, S.M.
Effect of pH and ionic strength on mu- and m-calpain inhibition by calpastatin
J. Anim. Sci.
83
1370-1376
2005
Sus scrofa
Carlin, K.R.; Huff-Lonergan, E.; Rowe, L.J.; Lonergan, S.M.
Effect of oxidation, pH, and ionic strength on calpastatin inhibition of mu- and m-calpain
J. Anim. Sci.
84
925-937
2006
Sus scrofa
Guerini, D.; Pan, B.; Carafoli, E.
Expression, purification, and characterization of isoform 1 of the plasma membrane Ca2+ pump: focus on calpain sensitivity
J. Biol. Chem.
278
38141-38148
2003
Homo sapiens
Altznauer, F.; Conus, S.; Cavalli, A.; Folkers, G.; Simon, H.U.
Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis
J. Biol. Chem.
279
5947-5957
2004
Homo sapiens
Lee, F.Y.; Kim, D.W.; Karmin, J.A.; Hong, D.; Chang, S.S.; Fujisawa, M.; Takayanagi, H.; Bigliani, L.U.; Blaine, T.A.; Lee, H.J.
mu-Calpain regulates receptor activator of NF-kappaB ligand (RANKL)-supported osteoclastogenesis via NF-kappaB activation in RAW 264.7 cells
J. Biol. Chem.
280
29929-29936
2005
Mus musculus
Murphy, R.M.; Verburg, E.; Lamb, G.D.
Ca2+-activation of diffusible and bound pools of micro-calpain in rat skeletal muscle
J. Physiol.
576
595-612
2006
Rattus norvegicus
Vermaelen, M.; Sirvent, P.; Raynaud, F.; Astier, C.; Mercier, J.; Lacampagne, A.; Cazorla, O.
Differential localization of autolyzed calpains 1 and 2 in slow and fast skeletal muscles in the early phase of atrophy
Am. J. Physiol.
292
C1723-C1731
2007
Rattus norvegicus
Kumagai, K.; Ozaki, Y.; Nakanishi, T.; Inomata, M.; Furuno, T.; Nakanishi, M.; Ogasawara, M.S.
Role of mu-calpain in human decidua for recurrent miscarriage
Am. J. Reprod. Immunol.
59
339-346
2008
Homo sapiens
Kar, P.; Chakraborti, T.; Roy, S.; Choudhury, R.; Chakraborti, S.
Identification of calpastatin and mu-calpain and studies of their association in pulmonary smooth muscle mitochondria
Arch. Biochem. Biophys.
466
290-299
2007
Bos taurus
Kar, P.; Chakraborti, T.; Samanta, K.; Chakraborti, S.
Submitochondrial localization of associated mu-calpain and calpastatin
Arch. Biochem. Biophys.
470
176-186
2008
Bos taurus
Morita, M.; Banno, Y.; Dohjima, T.; Nozawa, S.; Fushimi, K.; Fan, D.G.; Ohno, T.; Miyazawa, K.; Liu, N.; Shimizu, K.
mu-Calpain is involved in the regulation of TNF-alpha-induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line
Biochem. Biophys. Res. Commun.
343
937-942
2006
Homo sapiens
Govindarajan, B.; Laird, J.; Salomon, R.G.; Bhattacharya, S.K.
Isolevuglandin-modified proteins, including elevated levels of inactive calpain-1, accumulate in glaucomatous trabecular meshwork
Biochemistry
47
817-825
2008
Homo sapiens
Berg, U.; Bang, P.; Carlsson-Skwirut, C.
Calpain proteolysis of insulin-like growth factor binding protein (IGFBP) -2 and -3, but not of IGFBP-1
Biol. Chem.
388
859-863
2007
Homo sapiens
Pfizer, J.; Assfalg-Machleidt, I.; Machleidt, W.; Schaschke, N.
Inhibition of human mu-calpain by conformationally constrained calpastatin peptides
Biol. Chem.
389
83-90
2008
Homo sapiens
Sha, D.; Jin, Y.; Wu, H.; Wei, J.; Lin, C.H.; Lee, Y.H.; Buddhala, C.; Kuchay, S.; Chishti, A.H.; Wu, J.Y.
Role of mu-calpain in proteolytic cleavage of brain L-glutamic acid decarboxylase
Brain Res.
1207C
9-18
2008
Mus musculus
Chicharro, R.; Alonso, M.; Mazo, M.T.; Aran, V.J.; Herradon, B.
Derivatives of 3-sec-butyl-1-oxo-2,3-dihydroisoquinoline as inhibitors of micro mu-calpain
ChemMedChem
1
710-714
2006
Homo sapiens, Sus scrofa
Randriamboavonjy, V.; Pistrosch, F.; Boelck, B.; Schwinger, R.H.; Dixit, M.; Badenhoop, K.; Cohen, R.A.; Busse, R.; Fleming, I.
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone
Circulation
117
52-60
2008
Homo sapiens
Saito, M.; Li, H.; Thompson, V.F.; Kunisaki, N.; Goll, D.E.
Purification and characterization of calpain and calpastatin from rainbow trout, Oncorhynchus mykiss
Comp. Biochem. Physiol. B
146B
445-455
2007
Oncorhynchus mykiss
Lee, H.L.; Sante-Lhoutellier, V.; Vigouroux, S.; Briand, Y.; Briand, M.
Calpain specificity and expression in chicken tissues
Comp. Biochem. Physiol. B
146B
88-93
2007
Gallus gallus
-
Scalia, R.; Gong, Y.; Berzins, B.; Zhao, L.J.; Sharma, K.
Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation: the role of mu-calpain
Diabetes
56
1842-1849
2007
Rattus norvegicus
Struewing, I.T.; Barnett, C.D.; Zhang, W.; Yadav, S.; Mao, C.D.
Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1
Exp. Cell Res.
313
3526-3541
2007
Bos taurus
Wu, M.; Yu, Z.; Fan, J.; Caron, A.; Whiteway, M.; Shen, S.H.
Functional dissection of human protease mu-calpain in cell migration using RNAi
FEBS Lett.
580
3246-3256
2006
Homo sapiens
Raynand, F.; Jond-Neeand C.; Mareilhac, A.; Frst, D.; Benyamin, Y.
Calpain 1-gamma filamin interaction in muscle cells: A possible in situ regulation by PKC-alpha
Int. J. Biochem. Cell Biol.
38
404-413
2006
Chlorocebus aethiops, Mus musculus
Casas, E.; White, S.N.; Wheeler, T.L.; Shackelford, S.D.; Koohmaraie, M.; Riley, D.G.; Chase, C.C.; Johnson, D.D.; Smith, T.P.
Effects of calpastatin and micro-calpain markers in beef cattle on tenderness traits
J. Anim. Sci.
84
520-525
2006
Bos taurus
Camou, J.P.; Marchello, J.A.; Thompson, V.F.; Mares, S.W.; Goll, D.E.
Effect of postmortem storage on activity of mu- and m-calpain in five bovine muscles
J. Anim. Sci.
85
2670-2681
2007
Bos taurus
Murphy, R.M.; Goodman, C.A.; McKenna, M.J.; Bennie, J.; Leikis, M.; Lamb, G.D.
Calpain-3 is autolyzed and hence activated in human skeletal muscle 24 h following a single bout of eccentric exercise
J. Appl. Physiol.
103
926-931
2007
Homo sapiens
Xu, L.; Deng, X.
Suppression of cancer cell migration and invasion by protein phosphatase 2A through dephosphorylation of micro- and m-calpains
J. Biol. Chem.
281
35567-35575
2006
Homo sapiens
Badugu, R.; Garcia, M.; Bondada, V.; Joshi, A.; Geddes, J.W.
N terminus of calpain 1 is a mitochondrial targeting sequence
J. Biol. Chem.
283
3409-3417
2008
Homo sapiens, Rattus norvegicus
Yaroslavskiy, B.B.; Sharrow, A.C.; Wells, A.; Robinson, L.J.; Blair, H.C.
Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility
J. Cell Sci.
120
2884-2894
2007
Homo sapiens
Upla, P.; Marjomaeki, V.; Nissinen, L.; Nylund, C.; Waris, M.; Hyypiae, T.; Heino, J.
Calpain 1 and 2 are required for RNA replication of echovirus 1
J. Virol.
82
1581-1590
2008
Homo sapiens
Covington, M.D.; Arrington, D.D.; Schnellmann, R.G.
Calpain 10 is required for cell viability and is decreased in the aging kidney
Am. J. Physiol. Renal Physiol.
296
F478-F486
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Honda, M.; Masui, F.; Kanzawa, N.; Tsuchiya, T.; Toyo-oka, T.
Specific knockdown of m-calpain blocks myogenesis with cDNA deduced from the corresponding RNAi
Am. J. Physiol. Cell Physiol.
294
C957-C965
2008
Mus musculus
Coulis, G.; Becila, S.; Herrera-Mendez, C.H.; Sentandreu, M.A.; Raynaud, F.; Richard, I.; Benyamin, Y.; Ouali, A.
Calpain 1 binding capacities of the N1-line region of titin are significantly enhanced by physiological concentrations of calcium
Biochemistry
47
9174-9183
2008
Bos taurus, Sus scrofa
Passiatore, G.; Rom, S.; Eletto, D.; Peruzzi, F.
HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity
Biochim. Biophys. Acta
1793
378-387
2009
Rattus norvegicus
Grossi, A.; Karlsson, A.H.; Lawson, M.A.
Mechanical stimulation of C2C12 cells increases m-calpain expression, focal adhesion plaque protein degradation
Cell Biol. Int.
32
615-622
2008
Mus musculus
Vissing, K.; Overgaard, K.; Nedergaard, A.; Fredsted, A.; Schjerling, P.
Effects of concentric and repeated eccentric exercise on muscle damage and calpain-calpastatin gene expression in human skeletal muscle
Eur. J. Appl. Physiol.
103
323-332
2008
Homo sapiens (P07384), Homo sapiens
Bevers, M.B.; Lawrence, E.; Maronski, M.; Starr, N.; Amesquita, M.; Neumar, R.W.
Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity
J. Neurochem.
108
1237-1250
2009
Rattus norvegicus
Sun, M.; Zhao, Y.; Gu, Y.; Xu, C.
Inhibition of nNOS reduces ischemic cell death through down-regulating calpain and caspase-3 after experimental stroke
Neurochem. Int.
54
339-346
2009
Rattus norvegicus
Jiang, L.; Wang, M.; Zhang, J.; Monticone, R.E.; Telljohann, R.; Spinetti, G.; Pintus, G.; Lakatta, E.G.
Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells
PLoS ONE
3
e2231
2008
Rattus norvegicus
Verburg, E.; Murphy, R.M.; Richard, I.; Lamb, G.D.
Involvement of calpains in Ca2+-induced disruption of excitation-contraction coupling in mammalian skeletal muscle fibers
Am. J. Physiol. Cell Physiol.
296
C1115-C1122
2009
Homo sapiens
Mani, S.K.; Balasubramanian, S.; Zavadzkas, J.A.; Jeffords, L.B.; Rivers, W.T.; Zile, M.R.; Mukherjee, R.; Spinale, F.G.; Kuppuswamy, D.
Calpain inhibition preserves myocardial structure and function following myocardial infarction
Am. J. Physiol. Heart Circ. Physiol.
297
H1744-H1751
2009
Mus musculus
Supinski, G.S.; Callahan, L.A.
Calpain activation contributes to endotoxin-induced diaphragmatic dysfunction
Am. J. Respir. Cell Mol. Biol.
42
80-87
2010
Mus musculus
Abell, A.D.; Jones, M.A.; Coxon, J.M.; Morton, J.D.; Aitken, S.G.; McNabb, S.B.; Lee, H.Y.; Mehrtens, J.M.; Alexander, N.A.; Stuart, B.G.; Neffe, A.T.; Bickerstaffe, R.
Molecular modeling, synthesis, and biological evaluation of macrocyclic calpain inhibitors
Angew. Chem. Int. Ed. Engl.
48
1455-1458
2009
Ovis aries
Aviles, C.; Azor, P.J.; Pannier, L.; Hamill, R.M.; Membrillo, A.; Molina, A.
New single nucleotide polymorphisms in the mu-calpain gene in Spanish maternal beef breeds
Anim. Biotechnol.
20
161-164
2009
Bos taurus (C6ERB9), Bos taurus (C6ERC0), Bos taurus (C6ERC1), Bos taurus
Kar, P.; Samanta, K.; Shaikh, S.; Chowdhury, A.; Chakraborti, T.; Chakraborti, S.
Mitochondrial calpain system: an overview
Arch. Biochem. Biophys.
495
1-7
2010
Rattus norvegicus
Matsunaga, T.; Yamamoto, G.; Tachikawa, T.
Expression of typical calpains in mouse molar
Arch. Oral Biol.
54
885-892
2009
Mus musculus
Sergeev, I.N.
1,25-Dihydroxyvitamin D3 induces Ca2+-mediated apoptosis in adipocytes via activation of calpain and caspase-12
Biochem. Biophys. Res. Commun.
384
18-21
2009
Homo sapiens
Hayakawa, M.; Hayakawa, H.; Matsuyama, Y.; Tamemoto, H.; Okazaki, H.; Tominaga, S.
Mature interleukin-33 is produced by calpain-mediated cleavage in vivo
Biochem. Biophys. Res. Commun.
387
218-222
2009
Homo sapiens
Sahara, S.; Yamashima, T.
Calpain-mediated Hsp70.1 cleavage in hippocampal CA1 neuronal death
Biochem. Biophys. Res. Commun.
393
806-811
2010
Macaca fuscata
Jiao, W.; McDonald, D.Q.; Coxon, J.M.; Parker, E.J.
Molecular modeling studies of peptide inhibitors highlight the importance of conformational prearrangement for inhibition of calpain
Biochemistry
49
5533-5539
2010
Homo sapiens
Zhang, P.; Sridharan, D.M.; Lambert, M.W.
Knockdown of micro-calpain in Fanconi Anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair
Biochemistry
49
5570-5581
2010
Homo sapiens
Ozaki, T.; Yamashita, T.; Ishiguro, S.
Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria
Biochim. Biophys. Acta
1793
1848-1859
2009
Rattus norvegicus
Mellgren, R.L.; Miyake, K.; Kramerova, I.; Spencer, M.J.; Bourg, N.; Bartoli, M.; Richard, I.; Greer, P.A.; McNeil, P.L.
Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases
Biochim. Biophys. Acta
1793
1886-1893
2009
Homo sapiens
Kelly, J.C.; Cuerrier, D.; Graham, L.A.; Campbell, R.L.; Davies, P.L.
Profiling of calpain activity with a series of FRET-based substrates
Biochim. Biophys. Acta
1794
1505-1509
2009
Homo sapiens
Goncalves, I.; Nitulescu, M.; Saido, T.; Dias, N.; Pedro, L.; e Fernandes, J.; Ares, M.; Poern-Ares, I.
Activation of calpain-1 in human carotid artery atherosclerotic lesions
BMC Cardiovasc. Disord.
9
26
2009
Homo sapiens
Levesque, S.; Wilson, B.; Gregoria, V.; Thorpe, L.B.; Dallas, S.; Polikov, V.S.; Hong, J.S.; Block, M.L.
Reactive microgliosis: extracellular micro-calpain and microglia-mediated dopaminergic neurotoxicity
Brain
133
808-821
2010
Rattus norvegicus
Li, Y.; Gong, Z.H.; Sheng, L.; Gong, Y.T.; Tan, X.Y.; Li, W.M.; Dong, D.L.; Yang, B.F.; Fu, S.B.; Xue, H.J.
Anti-apoptotic effects of a calpain inhibitor on cardiomyocytes in a canine rapid atrial fibrillation model
Cardiovasc. Drugs Ther.
23
361-368
2009
Canis lupus familiaris
Li, X.; Li, Y.; Shan, L.; Shen, E.; Chen, R.; Peng, T.
Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia
Cardiovasc. Res.
83
72-79
2009
Rattus norvegicus
Li, Y.; Li, Y.; Feng, Q.; Arnold, M.; Peng, T.
Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes
Cardiovasc. Res.
84
100-110
2009
Rattus norvegicus
Miyazaki, T.; Honda, K.; Ohata, H.
m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions
Cardiovasc. Res.
85
530-541
2010
Mus musculus
Blachford, C.; Celic, A.; Petri, E.T.; Ehrlich, B.E.
Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by mu-calpain disrupts calcium binding
Cell Calcium
46
257-262
2009
Homo sapiens
Dean, P.; Muehlen, S.; Quitard, S.; Kenny, B.
The bacterial effectors EspG and EspG2 induce a destructive calpain activity that is kept in check by the co-delivered Tir effector
Cell. Microbiol.
12
1308-1321
2010
Homo sapiens
Murphy, R.M.
Calpains, skeletal muscle function and exercise
Clin. Exp. Pharmacol. Physiol.
37
385-391
2010
Homo sapiens, Rattus norvegicus
Li, Z.; Cao, B.; Zhao, B.; Yang, X.; Fan, M.Z.; Yang, J.
Decreased expression of calpain and calpastatin mRNA during development is highly correlated with muscle protein accumulation in neonatal pigs
Comp. Biochem. Physiol. A
152
498-503
2009
Sus scrofa (P35750)
Pietsch, M.; Chua, K.C.; Abell, A.D.
Calpains: attractive targets for the development of synthetic inhibitors
Curr. Top. Med. Chem.
10
270-293
2010
Homo sapiens
Le Goff, E.; Vallentin, A.; Harmand, P.O.; Aldrian-Herrada, G.; Rebiere, B.; Roy, C.; Benyamin, Y.; Lebart, M.C.
Characterization of L-plastin interaction with beta integrin and its regulation by micro-calpain
Cytoskeleton (Hoboken)
67
286-296
2010
Homo sapiens
Roumes, H.; Leloup, L.; Dargelos, E.; Brustis, J.J.; Daury, L.; Cottin, P.
Calpains: markers of tumor aggressiveness?
Exp. Cell Res.
316
1587-1599
2010
Homo sapiens
Vosler, P.S.; Sun, D.; Wang, S.; Gao, Y.; Kintner, D.B.; Signore, A.P.; Cao, G.; Chen, J.
Calcium dysregulation induces apoptosis-inducing factor release: cross-talk between PARP-1- and calpain-signaling pathways
Exp. Neurol.
218
213-220
2009
Rattus norvegicus
Joshi, A.; Bondada, V.; Geddes, J.W.
Mitochondrial micro-calpain is not involved in the processing of apoptosis-inducing factor
Exp. Neurol.
218
221-227
2009
Rattus norvegicus
Li, Y.; Bondada, V.; Joshi, A.; Geddes, J.W.
Calpain 1 and Calpastatin expression is developmentally regulated in rat brain
Exp. Neurol.
220
316-319
2009
Rattus norvegicus
Bevers, M.B.; Ingleton, L.P.; Che, D.; Cole, J.T.; Li, L.; Da, T.; Kopil, C.M.; Cohen, A.S.; Neumar, R.W.
RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia
Exp. Neurol.
224
170-177
2010
Rattus norvegicus
Choi, Y.Y.; Jung, S.Y.; Cho, P.Y.; Soh, B.Y.; Zheng, B.; Kim, S.Y.; Park, K.I.; Park, H.
Confocal microscopic findings of cysteine protease calpain in Plasmodium falciparum
Exp. Parasitol.
124
341-345
2010
Plasmodium falciparum, Plasmodium falciparum FCR-3
Ravulapalli, R.; Campbell, R.L.; Gauthier, S.Y.; Dhe-Paganon, S.; Davies, P.L.
Distinguishing between calpain heterodimerization and homodimerization
FEBS J.
276
973-982
2009
Homo sapiens
Simonin, Y.; Disson, O.; Lerat, H.; Antoine, E.; Biname, F.; Rosenberg, A.R.; Desagher, S.; Lassus, P.; Bioulac-Sage, P.; Hibner, U.
Calpain activation by hepatitis C virus proteins inhibits the extrinsic apoptotic signaling pathway
Hepatology
50
1370-1379
2009
Homo sapiens
Dewamitta, S.R.; Nomura, T.; Kawamura, I.; Hara, H.; Tsuchiya, K.; Kurenuma, T.; Shen, Y.; Daim, S.; Yamamoto, T.; Qu, H.; Sakai, S.; Xu, Y.; Mitsuyama, M.
Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes
Infect. Immun.
78
1884-1894
2010
Mus musculus
Martin-Villar, E.; Yurrita, M.M.; Fernandez-Munoz, B.; Quintanilla, M.; Renart, J.
Regulation of podoplanin/PA2.26 antigen expression in tumour cells. Involvement of calpain-mediated proteolysis
Int. J. Biochem. Cell Biol.
41
1421-1429
2009
Homo sapiens
Liu, L.; Xing, D.; Chen, W.R.
Micro-calpain regulates caspase-dependent and apoptosis inducing factor-mediated caspase-independent apoptotic pathways in cisplatin-induced apoptosis
Int. J. Cancer
125
2757-2766
2009
Homo sapiens
Weber, H.; Huehns, S.; Luethen, F.; Jonas, L.
Calpain-mediated breakdown of cytoskeletal proteins contributes to cholecystokinin-induced damage of rat pancreatic acini
Int. J. Exp. Pathol.
90
387-399
2009
Rattus norvegicus
Wu, Y.; Zhang, L.; Jin, H.; Zhou, J.; Xie, Z.
The role of calpain-calpastatin system in the development of stress urinary incontinence
Int. Urogynecol. J. Pelvic. Floor Dysfunct.
21
63-68
2010
Homo sapiens
Weaver, A.D.; Bowker, B.C.; Gerrard, D.E.
Sarcomere length influences mu-calpain-mediated proteolysis of bovine myofibrils
J. Anim. Sci.
87
2096-2103
2009
Sus scrofa
Lehti, M.; Kivelae, R.; Komi, P.; Komulainen, J.; Kainulainen, H.; Kyroelaeinen, H.
Effects of fatiguing jumping exercise on mRNA expression of titin-complex proteins and calpains
J. Appl. Physiol.
106
1419-1424
2009
Homo sapiens
De Maria, A.; Shi, Y.; Kumar, N.M.; Bassnett, S.
Calpain expression and activity during lens fiber cell differentiation
J. Biol. Chem.
284
13542-13550
2009
Mus musculus
Gafni, J.; Cong, X.; Chen, S.F.; Gibson, B.W.; Ellerby, L.M.
Calpain-1 cleaves and activates caspase-7
J. Biol. Chem.
284
25441-25449
2009
Homo sapiens
Stifanese, R.; Averna, M.; De Tullio, R.; Pedrazzi, M.; Beccaria, F.; Salamino, F.; Milanese, M.; Bonanno, G.; Pontremoli, S.; Melloni, E.
Adaptive modifications in the calpain/calpastatin system in brain cells after persistent alteration in Ca2+ homeostasis
J. Biol. Chem.
285
631-643
2010
Mus musculus
Liu, T.; Schneider, R.A.; Shah, V.; Huang, Y.; Likhotvorik, R.I.; Keshvara, L.; Hoyt, D.G.
Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells
J. Inflamm.
6
20
2009
Sus scrofa
OConnell, M.P.; Fiori, J.L.; Baugher, K.M.; Indig, F.E.; French, A.D.; Camilli, T.C.; Frank, B.P.; Earley, R.; Hoek, K.S.; Hasskamp, J.H.; Elias, E.G.; Taub, D.D.; Bernier, M.; Weeraratna, A.T.
Wnt5A activates the calpain-mediated cleavage of filamin A
J. Invest. Dermatol.
129
1782-1789
2009
Homo sapiens
Kang, D.H.; Jun, K.Y.; Lee, J.P.; Pak, C.S.; Na, Y.; Kwon, Y.
Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity
J. Med. Chem.
52
3093-3097
2009
Homo sapiens
Averna, M.; Stifanese, R.; De Tullio, R.; Beccaria, F.; Salamino, F.; Pontremoli, S.; Melloni, E.
Calpain-mediated activation of NO synthase in human neuroblastoma SK-N-BE cells
J. Neurochem.
110
412-421
2009
Homo sapiens
Wang, Y.; Kim, N.S.; Li, X.; Greer, P.A.; Koehler, R.C.; Dawson, V.L.; Dawson, T.M.
Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos)
J. Neurochem.
110
687-696
2009
Homo sapiens
Brustovetsky, T.; Bolshakov, A.; Brustovetsky, N.
Calpain activation and Na+/Ca2+ exchanger degradation occur downstream of calcium deregulation in hippocampal neurons exposed to excitotoxic glutamate
J. Neurosci. Res.
88
1317-1328
2010
Rattus norvegicus
Xu, J.; Kurup, P.; Zhang, Y.; Goebel-Goody, S.M.; Wu, P.H.; Hawasli, A.H.; Baum, M.L.; Bibb, J.A.; Lombroso, P.J.
Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP
J. Neurosci.
29
9330-9343
2009
Homo sapiens
Zadran, S.; Jourdi, H.; Rostamiani, K.; Qin, Q.; Bi, X.; Baudry, M.
Brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation
J. Neurosci.
30
1086-1095
2010
Homo sapiens
Ma, H.; Tochigi, A.; Shearer, T.R.; Azuma, M.
Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells
J. Ocul. Pharmacol. Ther.
25
409-414
2009
Homo sapiens
Alonso, M.; Chicharro, R.; Miranda, C.; Aran, V.J.; Maestro, M.A.; Herradon, B.
X-ray diffraction, solution structure, and computational studies on derivatives of (3-sec-butyl-2,3-dihydro-1H-isoquinolin-4-ylidene)acetic acid: compounds with activity as calpain inhibitors
J. Org. Chem.
75
342-352
2010
Homo sapiens
Shimazawa, M.; Suemori, S.; Inokuchi, Y.; Matsunaga, N.; Nakajima, Y.; Oka, T.; Yamamoto, T.; Hara, H.
A novel calpain inhibitor, ((1S)-1-((((1S)-1-Benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester (SNJ-1945), reduces murine retinal cell death in vitro and in vivo
J. Pharmacol. Exp. Ther.
332
380-387
2010
Mus musculus
Wang, L.; Duan, L.; Li, X.; Li, G.
Acute-exercise-induced alterations in calpain and calpastatin expression in rat muscle
J. Sport Rehabil.
18
213-228
2009
Rattus norvegicus
Rudic, B.; Song, H.; Breedijk, A.; Brinkkoetter, P.; Beck, G.; Yard, B.; Ponelies, N.
Hypothermic preservation up-regulates calpain expression and increases ubiquitination in cultured vascular endothelial cells: influence of dopamine pretreatment
J. Surg. Res.
160
325-332
2010
Homo sapiens
Pomponio, L.; Ertbjerg, P.; Karlsson, A.H.; Costa, L.N.; Lametsch, R.
Influence of early pH decline on calpain activity in porcine muscle
Meat Sci.
85
110-114
2010
Sus scrofa
Lindahl, G.; Lagerstedt, A.; Ertbjerg, P.; Sampels, S.; Lundstroem, K.
Ageing of large cuts of beef loin in vacuum or high oxygen modified atmosphere--effect on shear force, calpain activity, desmin degradation and protein oxidation
Meat Sci.
85
160-166
2010
Bos taurus
Tang, R.; Yu, B.; Zhang, K.; Guo, X.; Tian, G.; Huang, Z.; Chen, X.; Chen, D.
Effects of nutritional level on pork quality and gene expression of micro-calpain and calpastatin in muscle of finishing pigs
Meat Sci.
85
768-771
2010
Sus scrofa
Hu, H.; Li, X.; Li, Y.; Wang, L.; Mehta, S.; Feng, Q.; Chen, R.; Peng, T.
Calpain-1 induces apoptosis in pulmonary microvascular endothelial cells under septic conditions
Microvasc. Res.
78
33-39
2009
Mus musculus
Juszczuk-Kubiak, E.; Flisikowski, K.; Wicinska, K.
A new SNP in the 3UTR region of the bovine calpain small subunit (CAPNS1) gene
Mol. Biol. Rep.
37
473-476
2010
Bos taurus
Hamelet, J.; Couty, J.P.; Crain, A.M.; Noll, C.; Postic, C.; Paul, J.L.; Delabar, J.M.; Viguier, M.; Janel, N.
Calpain activation is required for homocysteine-mediated hepatic degradation of inhibitor Ikappa B alpha
Mol. Genet. Metab.
97
114-120
2009
Mus musculus
Yamada, M.; Yoshida, Y.; Mori, D.; Takitoh, T.; Kengaku, M.; Umeshima, H.; Takao, K.; Miyakawa, T.; Sato, M.; Sorimachi, H.; Wynshaw-Boris, A.; Hirotsune, S.
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly
Nat. Med.
15
1202-1207
2009
Mus musculus
Esteves, A.R.; Arduino, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.
Dysfunctional mitochondria uphold calpain activation: contribution to Parkinsons disease pathology
Neurobiol. Dis.
37
723-730
2010
Homo sapiens
Colak, A.; Kaya, M.; Karaoglan, A.; Sagmanligil, A.; Akdemir, O.; Sahan, E.; Celik, O.
Calpain inhibitor AK 295 inhibits calpain-induced apoptosis and improves neurologic function after traumatic spinal cord injury in rats
Neurocirugia (Astur)
20
245-254
2009
Rattus norvegicus
Kulkarni, S.; Reddy, K.B.; Esteva, F.J.; Moore, H.C.; Budd, G.T.; Tubbs, R.R.
Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer
Oncogene
29
1339-1350
2010
Homo sapiens
Nanduri, J.; Wang, N.; Yuan, G.; Khan, S.A.; Souvannakitti, D.; Peng, Y.J.; Kumar, G.K.; Garcia, J.A.; Prabhakar, N.R.
Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities
Proc. Natl. Acad. Sci. USA
106
1199-1204
2009
Rattus norvegicus
Chandramohanadas, R.; Davis, P.H.; Beiting, D.P.; Harbut, M.B.; Darling, C.; Velmourougane, G.; Lee, M.Y.; Greer, P.A.; Roos, D.S.; Greenbaum, D.C.
Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells
Science
324
794-797
2009
Homo sapiens
Hou, G.; Huang, M.; Gao, X.; Li, J.; Gao, H.; Ren, H.; Xu, S.
Association of calpain 1 (CAPN1) and HRSP12 allelic variants in beef cattle with carcass traits
Afr. J. Biotechnol.
10
13714-13718
2011
Bos taurus
-
Kim, D.S.; Han, B.G.; Park, K.S.; Lee, B.I.; Kim, S.Y.; Bae, C.D.
I-kappaBalpha depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway
Biochem. Biophys. Res. Commun.
399
300-306
2010
Homo sapiens
Menon, S.; Kang, C.M.; Beningo, K.A.
Galectin-3 secretion and tyrosine phosphorylation is dependent on the calpain small subunit, Calpain 4
Biochem. Biophys. Res. Commun.
410
91-96
2011
Mus musculus
Chen, Q.; Paillard, M.; Gomez, L.; Ross, T.; Hu, Y.; Xu, A.; Lesnefsky, E.J.
Activation of mitochondrial mu-calpain increases AIF cleavage in cardiac mitochondria during ischemia-reperfusion
Biochem. Biophys. Res. Commun.
415
533-538
2011
Mus musculus
Yu, L.; Tang, H.; Jiang, X.H.; Tsang, L.L.; Chung, Y.W.; Chan, H.C.
Involvement of calpain-I and microRNA34 in kanamycin-induced apoptosis of inner ear cells
Cell Biol. Int.
34
1219-1225
2010
Mus musculus
MacQueen, D.; Delbridge, M.; Manthri, S.; Johnston, I.
A newly classified vertebrate calpain protease, directly ancestral to CAPN1 and 2, episodically evolved a restricted physiological function in placental mammals
Mol. Biol. Evol.
27
1886-1902
2010
Anolis carolinensis, Danio rerio, Mus musculus, Notamacropus eugenii, Ornithorhynchus anatinus, Sus scrofa, Taeniopygia guttata, Xenopus laevis
Panigrahi, A.K.; Zhang, N.; Mao, Q.; Pati, D.
Calpain-1 cleaves Rad21 to promote sister chromatid separation
Mol. Cell. Biol.
31
4335-4347
2011
Homo sapiens
Bastian, Y.; Roa-Espitia, A.; Mujica, A.; Hernandez-Gonzalez, E.
Calpain modulates capacitation and acrosome reaction through cleavage of the spectrin cytoskeleton
Reproduction
140
673-684
2010
Cavia porcellus
Stifanese, R.; Averna, M.; De Tullio, R.; Pedrazzi, M.; Milanese, M.; Bonifacino, T.; Bonanno, G.; Salamino, F.; Pontremoli, S.; Melloni, E.
Role of calpain-1 in the early phase of experimental ALS
Arch. Biochem. Biophys.
562
1-8
2014
Mus musculus
Villalpando Rodriguez, G.E.; Torriglia, A.
Calpain 1 induce lysosomal permeabilization by cleavage of lysosomal associated membrane protein 2
Biochim. Biophys. Acta
1833
2244-2253
2013
Mus musculus, Rattus norvegicus
Zheng, D.; Wang, G.; Li, S.; Fan, G.C.; Peng, T.
Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation
Biochim. Biophys. Acta
1852
882-892
2015
Mus musculus, Rattus norvegicus
Gao, H.; Geng, Z.
Calpain I activity and its relationship with hippocampal neuronal death in pilocarpine-induced status epilepticus rat model
Cell Biochem. Biophys.
66
371-377
2013
Rattus norvegicus
Chang, Y.S.; Stromer, M.H.; Chou, R.G.
mu-Calpain is involved in the postmortem proteolysis of gizzard smooth muscle
Food Chem.
139
384-388
2013
Anas platyrhynchos, Anser anser
Prangsaengtong, O.; Senda, K.; Doki, Y.; Park, J.Y.; Jo, M.; Sakurai, H.; Shibahara, N.; Saiki, I.; Koizumi, K.
Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation
Hum. Cell
25
36-44
2012
Homo sapiens
Van Ba, H.; Inho, H.
Significant role of mu-calpain (CANP1) in proliferation/survival of bovine skeletal muscle satellite cells
In Vitro Cell. Dev. Biol. Anim.
49
785-797
2013
Bos taurus
Mohrhauser, D.A.; Lonergan, S.M.; Huff-Lonergan, E.; Underwood, K.R.; Weaver, A.D.
Calpain-1 activity in bovine muscle is primarily influenced by temperature, not pH decline
J. Anim. Sci.
92
1261-1270
2014
Bos taurus
Averna, M.; De Tullio, R.; Pedrazzi, M.; Bavestrello, M.; Pellegrini, M.; Salamino, F.; Pontremoli, S.; Melloni, E.
Interaction between calpain-1 and HSP90: new insights into the regulation of localization and activity of the protease
PLoS ONE
10
e0116738
2015
Homo sapiens
Santos, D.M.; Xavier, J.M.; Morgado, A.L.; Sola, S.; Rodrigues, C.M.
Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation
PLoS ONE
7
e33468
2012
Mus musculus
Valero, J.G.; Cornut-Thibaut, A.; Juge, R.; Debaud, A.L.; Gimenez, D.; Gillet, G.; Bonnefoy-Berard, N.; Salgado, J.; Salles, G.; Aouacheria, A.; Kucharczak, J.
mu-Calpain conversion of antiapoptotic Bfl-1 (BCL2A1) into a prodeath factor reveals two distinct alpha-helices inducing mitochondria-mediated apoptosis
PLoS ONE
7
e38620
2012
Sus scrofa
Fan, X.; Zhang, Q.; You, C.; Qian, Y.; Gao, J.; Liu, P.; Chen, H.; Song, H.; Chen, Y.; Chen, K.; Zhou, Y.
Proteolysis of the human DNA polymerase delta smallest subunit p12 by mu-calpain in calcium-triggered apoptotic HeLa cells
PLoS ONE
9
e93642
2014
Homo sapiens
Jiang, S.; Shao, C.; Tang, F.; Wang, W.; Zhu, X.
Dynamin-like protein 1 cleavage by calpain in Alzheimers disease
Aging Cell
18
e12912
2019
Homo sapiens (P07384)
Kumchantuek, T.; Nakata, H.; Sakulsak, N.; Yamamoto, M.; Iseki, S.
Expression and localization of calpain 3 in the submandibular gland of mice
Arch. Oral Biol.
70
9-15
2016
Mus musculus (O35350)
Randriamboavonjy, V.; Kyselova, A.; Elgheznawy, A.; Zukunft, S.; Wittig, I.; Fleming, I.
Calpain 1 cleaves and inactivates prostacyclin synthase in mesenteric arteries from diabetic mice
Basic Res. Cardiol.
112
10
2017
Mus musculus (O35350)
Campbell, J.S.; Hallett, M.B.
Active calpain in phagocytically competent human neutrophils electroinjection of fluorogenic calpain substrate
Biochem. Biophys. Res. Commun.
457
341-346
2015
Homo sapiens (P07384), Homo sapiens
Chen, Q.; Lesnefsky, E.J.
Heart mitochondria and calpain 1 Location, function, and targets
Biochim. Biophys. Acta
1852
2372-2378
2015
Homo sapiens (P07384)
Jantos, K.; Kling, A.; Mack, H.; Hornberger, W.; Moeller, A.; Nimmrich, V.; Lao, Y.; Nijsen, M.
Discovery of ABT-957 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability
Bioorg. Med. Chem. Lett.
29
1968-1973
2019
Homo sapiens (P07384)
Ni, R.; Zheng, D.; Xiong, S.; Hill, D.J.; Sun, T.; Gardiner, R.B.; Fan, G.C.; Lu, Y.; Abel, E.D.; Greer, P.A.; Peng, T.
Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type 1 diabetic hearts a novel mechanism contributing to diabetic cardiomyopathy
Diabetes
65
255-268
2016
Mus musculus (O35350), Mus musculus
Biswas, A.K.; Tandon, S.
Single-step purification of calpain-1, calpain-2, and calpastatin using anion-exchange chromatography
Methods Mol. Biol.
1915
3-11
2019
Gallus gallus (P00789)
Wang, Y.; Lopez, D.; Davey, P.G.; Cameron, D.J.; Nguyen, K.; Tran, J.; Marquez, E.; Liu, Y.; Bi, X.; Baudry, M.
Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury
Neurobiol. Dis.
93
121-128
2016
Mus musculus (O35350)
Nwankwo, J.O.; Gremmel, T.; Gerrits, A.J.; Mithila, F.J.; Warburton, R.R.; Hill, N.S.; Lu, Y.; Richey, L.J.; Jakubowski, J.A.; Frelinger, A.L.; Chishti, A.H.
Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease
Thromb. Res.
160
58-65
2017
Mus musculus (O35350), Mus musculus
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