Reference on EC 3.4.22.49 - separase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yanagida, M.
Cell cycle mechanisms of sister chromatid separation; roles of Cut1/separin and Cut2/securin
Genes Cells
5
1-8
2000
BRENDA: Saccharomyces cerevisiae, Homo sapiens, Schizosaccharomyces pombe
Textmining: eukaryota
Sullivan, M.; Lehane, C.; Uhlmann, F.
Orchestrating anaphase and mitotic exit: separase cleavage and localization of Slk19
Nat. Cell Biol.
3
771-777
2001
Saccharomyces cerevisiae
Amon, A.
Together until separin do us part
Nat. Cell Biol.
3
E12-14
2001
BRENDA: Saccharomyces cerevisiae, Homo sapiens, Schizosaccharomyces pombe
Textmining: vertebrata
Siomos, M.F.; Badrinath, A.; Pasierbek, P.; Livingstone, D.; White, J.; Glotzer, M.; Nasmyth, K.
Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans
Curr. Biol.
11
1825-1835
2001
BRENDA: Saccharomyces cerevisiae, Caenorhabditis elegans
Textmining: animal
Jager, H.; Herzig, A.; Lehner, C.F.; Heidmann, S.
Drosophila separase is required for sister chromatid separation and binds to PIM and THR
Genes Dev.
15
2572-2584
2001
BRENDA: Drosophila melanogaster
Textmining: Drosophila, eukaryota
Hauf, S.; Waizenegger, I.C.; Peters, J.M.
Cohesin cleavage by separase required for anaphase and cytokinesis in human cells
Science
293
1320-1323
2001
BRENDA: Homo sapiens
Textmining: Saccharomyces cerevisiae, vertebrata
Ross, K.E.; Cohen-Fix, O.
Separase: a conserved protease separating more than just sisters
Trends Cell Biol.
12
1-3
2002
Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Schizosaccharomyces pombe, Xenopus laevis
Zou, H.; Stemman, O.; Anderson, J.S.; Mann, M.; Kirschner, M.W.
Anaphase specific auto-cleavage of separase
FEBS Lett.
528
246-250
2002
BRENDA: Homo sapiens
Textmining: vertebrata
Hornig, N.C.; Knowles, P.P.; McDonald, N.Q.; Uhlmann, F.
The dual mechanism of separase regulation by securin
Curr. Biol.
12
973-982
2002
Saccharomyces cerevisiae
Waizenegger, I.C.; Gimenez-Abian, J.F.; Wernic, D.; Peters, J.M.
Regulation of human separase by securin binding and autocleavage
Curr. Biol.
12
1368-1378
2002
Homo sapiens
Stegmeier, F.; Visintin, R.; Amon, A.
Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase
Cell
108
207-220
2002
BRENDA: Saccharomyces cerevisiae
Textmining: Homo sapiens
Buonomo, S.B.C.; Rabitsch, K.P.; Fuchs, J.; Gruber, S.; Sullivan, M.; Uhlmann, F.; Petronczki, M.; Toth, A.; Nasmyth, K.
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19
Dev. Cell
4
727-739
2003
Saccharomyces cerevisiae
Sullivan, M.; Uhlmann, F.
A non-proteolytic function of separase links the onset of anaphase to mitotic exit
Nat. Cell Biol.
5
249-254
2003
Saccharomyces cerevisiae
Chestukhin, A.; Pfeffer, C.; Milligan, S.; DeCaprio, J.A.; Pellman, D.
Processing, localization, and requirement of human separase for normal anaphase progression
Proc. Natl. Acad. Sci. USA
100
4574-4579
2003
BRENDA: Homo sapiens
Textmining: eukaryota, yeasts, Saccharomyces cerevisiae
Queralt, E.; Lehane, C.; Novak, B.; Uhlmann, F.
Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast
Cell
125
719-732
2006
Saccharomyces cerevisiae
Kudo, N.R.; Wassmann, K.; Anger, M.; Schuh, M.; Wirth, K.G.; Xu, H.; Helmhart, W.; Kudo, H.; McKay, M.; Maro, B.; Ellenberg, J.; de Boer, P.; Nasmyth, K.
Resolution of chiasmata in oocytes requires separase-mediated proteolysis
Cell
126
135-146
2006
BRENDA: Mus musculus (P60330), Mus musculus
Textmining: animal, Saccharomyces cerevisiae, Xenopus
Gimenez-Abian, J.F.; Diaz-Martinez, L.A.; Waizenegger, I.C.; Gimenez-Martin, G.; Clarke, D.J.
Separase is required at multiple pre-anaphase cell cycle stages in human cells
Cell Cycle
4
1576-1584
2005
BRENDA: Homo sapiens
Textmining: Saccharomyces cerevisiae
Kawasaki, Y.; Nagao, K.; Nakamura, T.; Yanagida, M.
Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stresses
Cell Cycle
5
1831-1839
2006
Schizosaccharomyces pombe
Fan, H.Y.; Sun, Q.Y.; Zou, H.
Regulation of Separase in meiosis: Separase is activated at the metaphase I-II transition in Xenopus oocytes during meiosis
Cell Cycle
5
198-204
2006
BRENDA: Xenopus sp.
Textmining: Xenopus, eukaryota, vertebrata, Homo sapiens
Terret, M.E.; Wassmann, K.; Waizenegger, I.; Maro, B.; Peters, J.M.; Verlhac, M.H.
The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity
Curr. Biol.
13
1797-1802
2003
BRENDA: Mus musculus
Textmining: Saccharomyces cerevisiae, vertebrata
Kitajima, T.S.; Miyazaki, Y.; Yamamoto, M.; Watanabe, Y.
Rec8 cleavage by separase is required for meiotic nuclear divisions in fission yeast
EMBO J.
22
5643-5653
2003
BRENDA: Schizosaccharomyces pombe
Textmining: Mammalia
Nagao, K.; Yanagida, M.
Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase
Genes Cells
11
247-260
2006
Schizosaccharomyces pombe
Sullivan, M.; Hornig, N.C.; Porstmann, T.; Uhlmann, F.
Studies on substrate recognition by the budding yeast separase
J. Biol. Chem.
279
1191-1196
2004
BRENDA: Saccharomyces cerevisiae
Textmining: eukaryota, Homo sapiens
Wirth, K.G.; Wutz, G.; Kudo, N.R.; Desdouets, C.; Zetterberg, A.; Taghybeeglu, S.; Seznec, J.; Ducos, G.M.; Ricci, R.; Firnberg, N.; Peters, J.M.; Nasmyth, K.
Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression
J. Cell Biol.
172
847-860
2006
BRENDA: Mus musculus
Textmining: Saccharomyces cerevisiae
Pandey, R.; Heidmann, S.; Lehner, C.F.
Epithelial re-organization and dynamics of progression through mitosis in Drosophila separase complex mutants
J. Cell Sci.
118
733-742
2005
BRENDA: Drosophila sp. (in: flies)
Textmining: Drosophila, Saccharomyces cerevisiae
Ikai, N.; Yanagida, M.
Cdc48 is required for the stability of Cut1/separase in mitotic anaphase
J. Struct. Biol.
156
50-61
2006
Schizosaccharomyces pombe
Gorr, I.H.; Boos, D.; Stemmann, O.
Mutual inhibition of separase and Cdk1 by two-step complex formation
Mol. Cell
19
135-141
2005
Xenopus sp.
Papi, M.; Berdougo, E.; Randall, C.L.; Ganguly, S.; Jallepalli, P.V.
Multiple roles for separase auto-cleavage during the G2/M transition
Nat. Cell Biol.
7
1029-1035
2005
Homo sapiens
Nagao, K.; Adachi, Y.; Yanagida, M.
Separase-mediated cleavage of cohesin at interphase is required for DNA repair
Nature
430
1044-1048
2004
Schizosaccharomyces pombe
Liu, Z.; Makaroff, C.A.
Arabidopsis separase AESP is essential for embryo development and the release of cohesin during meiosis
Plant Cell
18
1213-1225
2006
BRENDA: Arabidopsis thaliana (Q5IBC5), Arabidopsis thaliana
Textmining: Arabidopsis, insertion sequences
Pereira, G.; Schiebel, E.
Separase regulates INCENP-Aurora B anaphase spindle function through Cdc14
Science
302
2120-2124
2003
Saccharomyces cerevisiae
Bembenek, J.N.; Richie, C.T.; Squirrell, J.M.; Campbell, J.M.; Eliceiri, K.W.; Poteryaev, D.; Spang, A.; Golden, A.; White, J.G.
Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separase
Development
134
3837-3848
2007
Caenorhabditis elegans
Shepard, J.L.; Amatruda, J.F.; Finkelstein, D.; Ziai, J.; Finley, K.R.; Stern, H.M.; Chiang, K.; Hersey, C.; Barut, B.; Freeman, J.L.; Lee, C.; Glickman, J.N.; Kutok, J.L.; Aster, J.C.; Zon, L.I.
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer
Genes Dev.
21
55-59
2007
BRENDA: Danio rerio
Textmining: Chondrichthyes, vertebrata
Boos, D.; Kuffer, C.; Lenobel, R.; Koerner, R.; Stemmann, O.
Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase
J. Biol. Chem.
283
816-823
2008
BRENDA: Homo sapiens
Textmining: Mammalia, Saccharomyces cerevisiae
Nakajima, M.; Kumada, K.; Hatakeyama, K.; Noda, T.; Peters, J.M.; Hirota, T.
The complete removal of cohesin from chromosome arms depends on separase
J. Cell Sci.
120
4188-4196
2007
BRENDA: Homo sapiens
Textmining: vertebrata
Pemberton, H.N.; Franklyn, J.A.; Boelaert, K.; Chan, S.Y.; Kim, D.S.; Kim, C.; Cheng, S.Y.; Kilby, M.D.; McCabe, C.J.
Separase, securin and Rad21 in neural cell growth
J. Cell. Physiol.
213
45-53
2007
BRENDA: Homo sapiens, Mus musculus
Textmining: Mus sp.
Gorr, I.H.; Reis, A.; Boos, D.; Wuehr, M.; Madgwick, S.; Jones, K.T.; Stemmann, O.
Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes
Nat. Cell Biol.
8
1035-1037
2006
Xenopus laevis
Terret, M.; Jallepalli, P.V.
Meiosis: separase strikes twice
Nat. Cell Biol.
8
910-911
2006
Saccharomyces cerevisiae, Mus musculus
Huang, X.; Andreu-Vieyra, C.V.; York, J.P.; Hatcher, R.; Lu, T.; Matzuk, M.M.; Zhang, P.
Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells
PLoS Biol.
6
e15
2008
BRENDA: Mus musculus
Textmining: Mus sp.
Adachi, Y.; Kokubu, A.; Ebe, M.; Nagao, K.; Yanagida, M.
Cut1/separase-dependent roles of multiple phosphorylation of fission yeast cohesion subunit Rad21 in post-replicative damage repair and mitosis
Cell Cycle
7
765-776
2008
Schizosaccharomyces pombe
Sak, A.; Fegers, I.; Groneberg, M.; Stuschke, M.
Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines
Cell Prolif.
41
660-670
2008
Homo sapiens
Sun, Y.; Kucej, M.; Fan, H.Y.; Yu, H.; Sun, Q.Y.; Zou, H.
Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner
Cell
137
123-132
2009
Homo sapiens
Meyer, R.; Fofanov, V.; Panigrahi, A.; Merchant, F.; Zhang, N.; Pati, D.
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers
Clin. Cancer Res.
15
2703-2710
2009
BRENDA: Homo sapiens
Textmining: Mus musculus
Clift, D.; Bizzari, F.; Marston, A.L.
Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase
Genes Dev.
23
766-780
2009
BRENDA: Anaplasma marginale
Textmining: Saccharomyces cerevisiae
Baskerville, C.; Segal, M.; Reed, S.I.
The protease activity of yeast separase (esp1) is required for anaphase spindle elongation independently of its role in cleavage of cohesin
Genetics
178
2361-2372
2008
BRENDA: Saccharomyces cerevisiae
Textmining: eukaryota
Queralt, E.; Uhlmann, F.
Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase
J. Cell Biol.
182
873-883
2008
Saccharomyces cerevisiae
Fujita, T.; Epperly, M.W.; Zou, H.; Greenberger, J.S.; Wan, Y.
Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells
Mol. Biol. Cell
19
5446-5455
2008
Mus musculus
Lu, Y.; Cross, F.
Mitotic exit in the absence of separase activity
Mol. Biol. Cell
20
1576-1591
2009
BRENDA: Saccharomyces cerevisiae (Q03018), Saccharomyces cerevisiae
Textmining: Homo sapiens
Huang, X.; Andreu-Vieyra, C.V.; Wang, M.; Cooney, A.J.; Matzuk, M.M.; Zhang, P.
Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation
Mol. Cell. Biol.
29
1498-1505
2009
BRENDA: Mus musculus
Textmining: Homo sapiens, vertebrata, Mus sp.
Bessat, M.; Ersfeld, K.
Functional characterization of cohesin SMC3 and separase and their roles in the segregation of large and minichromosomes in Trypanosoma brucei
Mol. Microbiol.
71
1371-1385
2009
BRENDA: Trypanosoma brucei
Textmining: minichromosomes
Zhang, N.; Ge, G.; Meyer, R.; Sethi, S.; Basu, D.; Pradhan, S.; Zhao, Y.J.; Li, X.N.; Cai, W.W.; El-Naggar, A.K.; Baladandayuthapani, V.; Kittrell, F.S.; Rao, P.H.; Medina, D.; Pati, D.
Overexpression of Separase induces aneuploidy and mammary tumorigenesis
Proc. Natl. Acad. Sci. USA
105
13033-13038
2008
Homo sapiens, Mus musculus
Basu, D.; Zhang, N.; Panigrahi, A.K.; Horton, T.M.; Pati, D.
Development and validation of a fluorogenic assay to measure separase enzyme activity
Anal. Biochem.
392
133-138
2009
BRENDA: Homo sapiens
Textmining: Mus sp.
Bembenek, J.N.; White, J.G.; Zheng, Y.
A role for separase in the regulation of RAB-11-positive vesicles at the cleavage furrow and midbody
Curr. Biol.
20
259-264
2010
Caenorhabditis elegans
Tsou, M.F.; Wang, W.J.; George, K.A.; Uryu, K.; Stearns, T.; Jallepalli, P.V.
Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells
Dev. Cell
17
344-354
2009
Homo sapiens
Katis, V.L.; Lipp, J.J.; Imre, R.; Bogdanova, A.; Okaz, E.; Habermann, B.; Mechtler, K.; Nasmyth, K.; Zachariae, W.
Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis
Dev. Cell
18
397-409
2010
Saccharomyces cerevisiae, Saccharomyces cerevisiae SK1
Wu, S.; Scheible, W.R.; Schindelasch, D.; Van Den Daele, H.; De Veylder, L.; Baskin, T.I.
A conditional mutation in Arabidopsis thaliana separase induces chromosome non-disjunction, aberrant morphogenesis and cyclin B1,1 stability
Development
137
953-961
2010
BRENDA: Arabidopsis thaliana
Textmining: eukaryota, plant
Kissen, R.; Bones, A.M.
Nitrile-specifier proteins involved in glucosinolate hydrolysis in Arabidopsis thaliana
J. Biol. Chem.
284
12057-12070
2009
Arabidopsis thaliana
Nakamura, A.; Arai, H.; Fujita, N.
Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement
J. Cell Biol.
187
607-614
2009
Homo sapiens
Kudo, N.R.; Anger, M.; Peters, A.H.; Stemmann, O.; Theussl, H.C.; Helmhart, W.; Kudo, H.; Heyting, C.; Nasmyth, K.
Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I
J. Cell Sci.
122
2686-2698
2009
BRENDA: Homo sapiens
Textmining: Mus musculus, Mus sp., Saccharomyces cerevisiae
Ishiguro, T.; Tanaka, K.; Sakuno, T.; Watanabe, Y.
Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase
Nat. Cell Biol.
12
500-506
2010
BRENDA: Homo sapiens
Textmining: Schizosaccharomyces pombe
Yang, X.; Boateng, K.A.; Strittmatter, L.; Burgess, R.; Makaroff, C.A.
Arabidopsis separase functions beyond the removal of sister chromatid cohesion during meiosis
Plant Physiol.
151
323-333
2009
BRENDA: Arabidopsis thaliana
Textmining: Arabidopsis
Vinod, P.K.; Freire, P.; Rattani, A.; Ciliberto, A.; Uhlmann, F.; Novak, B.
Computational modelling of mitotic exit in budding yeast: the role of separase and Cdc14 endocycles
J. R. Soc. Interface
8
1128-1141
2011
Saccharomyces cerevisiae
Kucej, M.; Zou, H.
DNA-dependent cohesin cleavage by separase
Nucleus
1
4-7
2011
Saccharomyces cerevisiae, Homo sapiens, Mus musculus
Moschou, P.N.; Bozhkov, P.V.
Separases: biochemistry and function
Physiol. Plant.
145
67-76
2012
Saccharomyces cerevisiae, Caenorhabditis elegans, Ricinus communis, Chlamydomonas reinhardtii, Drosophila melanogaster, Homo sapiens, Oryza sativa, Schizosaccharomyces pombe, Sorghum bicolor, Vitis vinifera, Cryptosporidium muris, Arabidopsis thaliana (Q5IBC5)
Yim, H.; Erikson, R.L.
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase
Proc. Natl. Acad. Sci. USA
107
19742-19747
2010
Homo sapiens
Bacac, M.; Fusco, C.; Planche, A.; Santodomingo, J.; Demaurex, N.; Leemann-Zakaryan, R.; Provero, P.; Stamenkovic, I.
Securin and separase modulate membrane traffic by affecting endosomal acidification
Traffic
12
615-626
2011
BRENDA: Homo sapiens
Textmining: Caenorhabditis elegans, Drosophila
Matsuo, K.; Ohsumi, K.; Iwabuchi, M.; Kawamata, T.; Ono, Y.; Takahashi, M.
Kendrin is a novel substrate for separase involved in the licensing of centriole duplication
Curr. Biol.
22
915-921
2012
Homo sapiens (Q14674)
Shindo, N.; Kumada, K.; Hirota, T.
Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition
Dev. Cell
23
112-123
2012
Mus musculus (P60330)
Yaakov, G.; Thorn, K.; Morgan, D.O.
Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation
Dev. Cell
23
124-136
2012
BRENDA: Saccharomyces cerevisiae (Q03018), Saccharomyces cerevisiae
Textmining: Indicator
Hellmuth, S.; Poehlmann, C.; Brown, A.; Boettger, F.; Sprinzl, M.; Stemmann, O.
Positive and negative regulation of vertebrate separase by cdk1-cyclin b1 may explain why securin is dispensable
J. Biol. Chem.
290
8002-8010
2015
BRENDA: Homo sapiens (Q14674)
Textmining: Mus sp.
Han, X.; Poon, R.Y.
Critical differences between isoforms of securin reveal mechanisms of separase regulation
Mol. Cell. Biol.
33
3400-3415
2013
Saccharomyces cerevisiae (Q03018)
Agircan, F.G.; Schiebel, E.
Sensors at centrosomes reveal determinants of local separase activity
PLoS Genet.
10
e1004672
2014
Homo sapiens (Q14674)
Ho, K.L.; Ma, L.; Cheung, S.; Manhas, S.; Fang, N.; Wang, K.; Young, B.; Loewen, C.; Mayor, T.; Measday, V.
A role for the budding yeast separase, Esp1, in Ty1 element retrotransposition
PLoS Genet.
11
e1005109
2015
BRENDA: Saccharomyces cerevisiae (Q03018), Saccharomyces cerevisiae
Textmining: transposons, insertion sequences
Haass, W.; Stehle, M.; Nittka, S.; Giehl, M.; Schrotz-King, P.; Fabarius, A.; Hofmann, W.K.; Seifarth, W.
The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib
PLoS ONE
7
e42863
2012
Homo sapiens (Q14674), Homo sapiens
Zhang, N.; Pati, D.
Biology and insights into the role of cohesin protease separase in human malignancies
Biol. Rev. Camb. Philos. Soc.
92
2070-2083
2017
BRENDA: Mus musculus (P60330), Mus musculus, Homo sapiens (Q14674), Homo sapiens
Textmining: Mus sp.
Do, H.T.; Zhang, N.; Pati, D.; Gilbertson, S.R.
Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase
Bioorg. Med. Chem. Lett.
26
4446-4450
2016
Homo sapiens (Q14674), Homo sapiens
Luo, S.; Tong, L.
Structural biology of the separase-securin complex with crucial roles in chromosome segregation
Curr. Opin. Struct. Biol.
49
114-122
2018
BRENDA: Saccharomyces cerevisiae, Thermochaetoides thermophila (G0SHM3), Caenorhabditis elegans (G5ED39), Caenorhabditis elegans, Thermochaetoides thermophila DSM 1495 (G0SHM3)
Textmining: Chaetomium thermophilum
Kumar, R.
Separase Function beyond cohesion cleavage and an emerging oncogene
J. Cell. Biochem.
118
1283-1299
2017
Caenorhabditis elegans, Arabidopsis thaliana (A0A1P8B3N4), Schizosaccharomyces pombe (P18296), Saccharomyces cerevisiae (Q03018), Drosophila melanogaster (Q9VRN6), Picea abies (R4XPW1), Schizosaccharomyces pombe ATCC 24843 (P18296)
Cipressa, F.; Morciano, P.; Bosso, G.; Mannini, L.; Galati, A.; Raffa, G.D.; Cacchione, S.; Musio, A.; Cenci, G.
A role for Separase in telomere protection
Nat. Commun.
7
10405
2016
BRENDA: Drosophila sp. (in: flies)
Textmining: Homo sapiens, Drosophila
Lin, Z.; Luo, X.; Yu, H.
Structural basis of cohesin cleavage by separase
Nature
532
131-134
2016
BRENDA: Thermochaetoides thermophila (G0SHM3), Thermochaetoides thermophila DSM 1495 (G0SHM3)
Textmining: Saccharomyces cerevisiae, Homo sapiens, Chaetomium thermophilum
Winter, A.; Schmid, R.; Bayliss, R.
Structural insights into separase architecture and substrate recognition through computational modelling of caspase-like and death domains
PLoS Comput. Biol.
11
e1004548
2015
BRENDA: Caenorhabditis elegans (G5ED39), Caenorhabditis elegans, Saccharomyces cerevisiae (Q03018), Homo sapiens (Q14674), Arabidopsis thaliana (Q5IBC5), Saccharomyces cerevisiae ATCC 204508 (Q03018)
Textmining: eukaryota
Blattner, A.C.; Chaurasia, S.; McKee, B.D.; Lehner, C.F.
Separase is required for homolog and sister disjunction during Drosophila melanogaster male meiosis, but not for biorientation of sister centromeres
PLoS Genet.
12
e1005996
2016
Drosophila melanogaster (Q9VRN6), Drosophila melanogaster
Monen, J.; Hattersley, N.; Muroyama, A.; Stevens, D.; Oegema, K.; Desai, A.
Separase cleaves the N-tail of the CENP-A related protein CPAR-1 at the meiosis I metaphase-anaphase transition in C. elegans
PLoS ONE
10
e0125382
2015
BRENDA: Caenorhabditis elegans (G5ED39), Caenorhabditis elegans
Textmining: eukaryota
Haass, W.; Kleiner, H.; Mueller, M.C.; Hofmann, W.K.; Fabarius, A.; Seifarth, W.
Measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay
PLoS ONE
10
e0133769
2015
Homo sapiens (Q14674), Homo sapiens
Uhlmann, F; Wernic, D; Poupart, MA; Koonin, EV; Nasmyth, K
Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast.
Cell
103
375-86
2000
Saccharomyces cerevisiae
Moschou, PN; Smertenko, AP; Minina, EA; Fukada, K; Savenkov, EI; Robert, S; Hussey, PJ; Bozhkov, PV
The caspase-related protease separase (extra spindle poles) regulates cell polarity and cytokinesis in Arabidopsis.
Plant Cell
25
2171-86
2013
Arabidopsis, Arabidopsis thaliana, Rattus
Kumar, P; Cheng, H; Paudyal, S; Nakamura, LV; Zhang, N; Li, JT; Sasidharan, R; Jeong, M; Pati, D
Haploinsufficiency of cohesin protease, Separase, promotes regeneration of hematopoietic stem cells in mice.
Stem Cells
2020
Mus sp., Mus musculus
Hayakawa, JI; Nikaido, H; Koizumi, T
Genetic polymorphism of the sixth component of complement (C6) in mice.
Immunogenetics
20
633-8
1984
Cuniculus
Jensen, S; Segal, M; Clarke, DJ; Reed, SI
A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1.
J Cell Biol
152
27-40
2001
Saccharomyces cerevisiae
Herzig, A; Lehner, CF; Heidmann, S
Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function.
Genes Dev
16
2443-54
2002
Drosophila
Fontanini, D; Jones, BL
SEP-1 - a subtilisin-like serine endopeptidase from germinated seeds of Hordeum vulgare L. cv. Morex.
Planta
215
885-93
2002
Hordeum vulgare
Nakamura, T; Nagao, K; Nakaseko, Y; Yanagida, M
Cut1/separase C-terminus affects spindle pole body positioning in interphase of fission yeast: pointed nuclear formation.
Genes Cells
7
1113-24
2002
Homo sapiens, Saccharomyces cerevisiae, Schizosaccharomyces pombe
Chestukhin, A; DeCaprio, JA
Western blot screening for monoclonal antibodies against human separase.
J Immunol Methods
274
105-13
2003
Homo sapiens
Matsumura, T; Yuasa, T; Hayashi, T; Obara, T; Kimata, Y; Yanagida, M
A brute force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securin plasmids.
Genes Cells
8
341-55
2003
plasmids, Schizosaccharomyces pombe, Transformation
Jäger, H; Herzig, B; Herzig, A; Sticht, H; Lehner, CF; Heidmann, S
Structure predictions and interaction studies indicate homology of separase N-terminal regulatory domains and Drosophila THR.
Cell Cycle
3
182-8
2004
Drosophila, Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, eukaryota
Ji, JY; Crest, J; Schubiger, G
Genetic interactions between Cdk1-CyclinB and the Separase complex in Drosophila.
Development
132
1875-84
2005
Drosophila
Heeger, S; Leismann, O; Schittenhelm, R; Schraidt, O; Heidmann, S; Lehner, CF
Genetic interactions of separase regulatory subunits reveal the diverged Drosophila Cenp-C homolog.
Genes Dev
19
2041-53
2005
Drosophila
Gerber, SA; Kettenbach, AN; Rush, J; Gygi, SP
The absolute quantification strategy: application to phosphorylation profiling of human separase serine 1126.
Methods Mol Biol
359
71-86
2007
Homo sapiens
Li, ZT; Wang, W; Zhao, Y; Wang, LX; Zhu, HS; Wu, WD; Wu, YM
[Change of structurol maintenance of chromosome (SMC)1, SMC3, Separase and Securin expression in BEAS-2B malignant transformation cell induced by coal tar pitch smoke extracts].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
28
776-80
2010
Transformation
Yang, X; Boateng, KA; Yuan, L; Wu, S; Baskin, TI; Makaroff, CA
The radially swollen 4 separase mutation of Arabidopsis thaliana blocks chromosome disjunction and disrupts the radial microtubule system in meiocytes.
PLoS One
6
e19459
2011
Arabidopsis thaliana, eukaryota
Mukherjee, M; Ge, G; Zhang, N; Huang, E; Nakamura, LV; Minor, M; Fofanov, V; Rao, PH; Herron, A; Pati, D
Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice.
PLoS One
6
e22167
2011
Mus sp.
Chiang, T; Schultz, R; Lampson, M
Age-Dependent Susceptibility of Chromosome Cohesion to Premature Separase Activation in Mouse Oocytes.
Biol Reprod
2011
Mus musculus
Kimura, K; Kimura, A
Rab6 is required for the exocytosis of cortical granules and the recruitment of separase to the granules during the oocyte-to-embryo transition in Caenorhabditis elegans.
J Cell Sci
125
5897-905
2012
Caenorhabditis elegans
Touati, SA; Cladière, D; Lister, LM; Leontiou, I; Chambon, JP; Rattani, A; Böttger, F; Stemmann, O; Nasmyth, K; Herbert, M; Wassmann, K
Cyclin A2 is required for sister chromatid segregation, but not separase control, in mouse oocyte meiosis.
Cell Rep
2
1077-87
2012
Mus musculus
Hellmuth, S; Rata, S; Brown, A; Heidmann, S; Novak, B; Stemmann, O
Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1.
Mol Cell
58
495-506
2015
Homo sapiens, Mus musculus
Shimizu, Y; Nagai, M; Yeasmin, AM; Koike, N; Talukdar, MW; Ushimaru, T
Elucidation of novel budding yeast separase mutants.
Biosci Biotechnol Biochem
80
473-8
2016
Saccharomyces cerevisiae, Drosophila
Guo, Z; Batiha, O; Bourouh, M; Fifield, E; Swan, A
Role of Securin, Separase and Cohesins in female meiosis and polar body formation in Drosophila.
J Cell Sci
129
531-42
2016
Drosophila
Agircan, FG; Hata, S; Nussbaum-Krammer, C; Atorino, E; Schiebel, E
Proximity mapping of human separase by the BioID approach.
Biochem Biophys Res Commun
478
656-62
2016
Homo sapiens, Caenorhabditis elegans
Luo, S; Tong, L
Molecular mechanism for the regulation of yeast separase by securin.
Nature
542
255-259
2017
Saccharomyces cerevisiae, Homo sapiens, Electron
Luo, S; Tong, L
Corrigendum: Molecular mechanism for the regulation of yeast separase by securin.
Nature
547
476
2017
Saccharomyces cerevisiae
Ruppenthal, S; Kleiner, H; Nolte, F; Fabarius, A; Hofmann, WK; Nowak, D; Seifarth, W
Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.
PLoS One
13
e0191734
2018
Transformation, Homo sapiens
Li, F; Zhang, N; Gorantla, S; Gilbertson, SR; Pati, D
The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes.
Front Pharmacol
9
313
2018
Homo sapiens, Mus musculus, Rattus
Nikalayevich, E; Bouftas, N; Wassmann, K
Detection of Separase Activity Using a Cleavage Sensor in Live Mouse Oocytes.
Methods Mol Biol
1818
99-112
2018
Mus musculus
Hellmuth, S; Gutiérrez-Caballero, C; Llano, E; Pendás, AM; Stemmann, O
Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation.
EMBO J
37
2018
Transformation, Mus sp.
Cromer, L; Jolivet, S; Singh, DK; Berthier, F; De Winne, N; De Jaeger, G; Komaki, S; Prusicki, MA; Schnittger, A; Guérois, R; Mercier, R
Patronus is the elusive plant securin, preventing chromosome separation by antagonizing separase.
Proc Natl Acad Sci U S A
116
16018-16027
2019
Fungi, Metazoa, plant
Li, J; Ouyang, YC; Zhang, CH; Qian, WP; Sun, QY
The cyclin B2/CDK1 complex inhibits separase activity in mouse oocyte meiosis I.
Development
146
2019
Mus musculus
Zhang, N; Sarkar, AK; Pati, D
Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.
Pathol Res Pract
216
152730
2020
Rattus
Zhang, N; Sarkar, AK; Li, F; Demerzhan, SA; Gilbertson, SR; Pati, D
Stability and pharmacokinetics of separase inhibitor-Sepin-1 in Sprague-Dawley rats.
Biochem Pharmacol
174
113808
2020
Rattus, Homo sapiens
Zhang, N; Sarkar, AK; Pati, D
Data set on Separase Inhibitor-Sepin-1 toxicity on organ weights, hematology and clinical parameters in Sprague-Dawley rats.
Data Brief
29
105159
2020
Rattus
Spiess, B; Kleiner, H; Flach, J; Fabarius, A; Saussele, S; Hofmann, WK; Seifarth, W
Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.
Ann Hematol
99
991-1006
2020
Homo sapiens, clinical samples
Adams, EE; He, Q; McKee, BD
How noncrossover homologs are conjoined and segregated in Drosophila male meiosis I: Stable but reversible homolog linkers require a novel Separase target protein.
PLoS Genet
16
e1008997
2020
Drosophila
Sterk, E; Hyun, BH; Rech, MA
Comparison of an ED triage sepsis screening tool and qSOFA in identifying CMS SEP-1 patients.
Am J Emerg Med
38
1995-1999
2020
Homo sapiens
Wang, R; Zang, W; Hu, B; Deng, D; Ling, X; Zhou, H; Su, M; Jiang, J
Serum ESPL1 Can Be Used as a Biomarker for Patients With Hepatitis B Virus-Related Liver Cancer: A Chinese Case-Control Study.
Technol Cancer Res Treat
19
1533033820980785
0
Homo sapiens, Hepatitis B virus
Yu, J; Raia, P; Ghent, CM; Raisch, T; Sadian, Y; Cavadini, S; Sabale, PM; Barford, D; Raunser, S; Morgan, DO; Boland, A
Structural basis of human separase regulation by securin and CDK1-cyclin B1.
Nature
596
138-142
2021
Homo sapiens, Electron, Caenorhabditis
Cigliano, RA; Cremona, G; Paparo, R; Termolino, P; Perrella, G; Gutzat, R; Consiglio, MF; Conicella, C
Histone Deacetylase AtHDA7 Is Required for Female Gametophyte and Embryo Development in Arabidopsis.
Plant Physiol
163
431-40
2013
Arabidopsis
Uhlmann, F
Chromosome cohesion and separation: from men and molecules.
Curr Biol
13
R104-14
2003
Homo sapiens, eukaryota
Sullivan, M; Higuchi, T; Katis, VL; Uhlmann, F
Cdc14 phosphatase induces rDNA condensation and resolves cohesin-independent cohesion during budding yeast anaphase.
Cell
117
471-82
2004
Saccharomyces cerevisiae, other sequences
Pfleghaar, K; Heubes, S; Cox, J; Stemmann, O; Speicher, MR
Securin is not required for chromosomal stability in human cells.
PLoS Biol
3
e416
2005
Homo sapiens
Nabti, I; Reis, A; Levasseur, M; Stemmann, O; Jones, KT
Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs.
Dev Biol
321
379-86
2008
Mus musculus
Wilkinson, D; Ramsdale, M
Proteases and caspase-like activity in the yeast Saccharomyces cerevisiae.
Biochem Soc Trans
39
1502-8
2011
Saccharomyces cerevisiae
Mukherjee, M; Ge, G; Zhang, N; Edwards, DG; Sumazin, P; Sharan, SK; Rao, PH; Medina, D; Pati, D
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas.
Oncogene
2013
Mus musculus, Homo sapiens, Metazoa, Mus sp.
Huis in 't Veld, PJ; Herzog, F; Ladurner, R; Davidson, IF; Piric, S; Kreidl, E; Bhaskara, V; Aebersold, R; Peters, JM
Characterization of a DNA exit gate in the human cohesin ring.
Science
346
968-72
2014
Homo sapiens, Electron
Moschou, PN; Savenkov, EI; Minina, EA; Fukada, K; Reza, SH; Gutierrez-Beltran, E; Sanchez-Vera, V; Suarez, MF; Hussey, PJ; Smertenko, AP; Bozhkov, PV
EXTRA SPINDLE POLES (Separase) controls anisotropic cell expansion in Norway spruce (Picea abies) embryos independently of its role in anaphase progression.
New Phytol
212
232-43
2016
Arabidopsis thaliana
Bachmann, G; Richards, MW; Winter, A; Beuron, F; Morris, E; Bayliss, R
A closed conformation of the Caenorhabditis elegans separase-securin complex.
Open Biol
6
160032
2016
Caenorhabditis elegans, Homo sapiens, Electron
Hatano, Y; Naoki, K; Suzuki, A; Ushimaru, T
Positive feedback promotes mitotic exit via the APC/C-Cdh1-separase-Cdc14 axis in budding yeast.
Cell Signal
28
1545-54
2016
Saccharomyces cerevisiae
Liu, C; Moschou, PN
Cutting in the middleman: hidden substrates at the interface between proteases and plant development.
New Phytol
2017
plant
Sparapani, S; Bachewich, C
Characterization of a novel separase-interacting protein and candidate new securin, Eip1p, in the fungal pathogen Candida albicans.
Mol Biol Cell
30
2469-2489
2019
Candida albicans, Homo sapiens
Mei, J; Huang, X; Zhang, P
Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts.
Curr Biol
11
1197-201
2001
Saccharomyces cerevisiae, Xenopus
Witzel, K; Abu Risha, M; Albers, P; Börnke, F; Hanschen, FS
Identification and Characterization of Three Epithiospecifier Protein Isoforms in Brassica oleracea.
Front Plant Sci
10
1552
2019
Arabidopsis thaliana
Yuasa, T; Hayashi, T; Ikai, N; Katayama, T; Aoki, K; Obara, T; Toyoda, Y; Maruyama, T; Kitagawa, D; Takahashi, K; Nagao, K; Nakaseko, Y; Yanagida, M
An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.
Genes Cells
9
1069-82
2004
plasmids, Schizosaccharomyces pombe, Transformation
Chiroli, E; Rancati, G; Catusi, I; Lucchini, G; Piatti, S
Cdc14 inhibition by the spindle assembly checkpoint prevents unscheduled centrosome separation in budding yeast.
Mol Biol Cell
20
2626-37
2009
Saccharomyces cerevisiae
Eicher, EM; Taylor, BA; Leighton, SC; Womack, JE
A serum protein polymorphism determinant on chromosome 9 of Mus musculus.
Mol Gen Genet
177
571-6
1980
Mus sp.
D'Eustachio, P; Owens, GC; Edelman, GM; Cunningham, BA
Chromosomal location of the gene encoding the neural cell adhesion molecule (N-CAM) in the mouse.
Proc Natl Acad Sci U S A
82
7631-5
1985
Mus sp.
Wang, Y; Yang, Z
A Gleason score-related outcome model for human prostate cancer: a comprehensive study based on weighted gene co-expression network analysis.
Cancer Cell Int
20
159
2020
Homo sapiens
Kamieniecki, RJ; Liu, L; Dawson, DS
FEAR but not MEN genes are required for exit from meiosis I.
Cell Cycle
4
1093-8
2005
Homo sapiens
Salah, SM; Nasmyth, K
Destruction of the securin Pds1p occurs at the onset of anaphase during both meiotic divisions in yeast.
Chromosoma
109
27-34
2000
Saccharomyces cerevisiae
Bickel, SE; Orr-Weaver, TL; Balicky, EM
The sister-chromatid cohesion protein ORD is required for chiasma maintenance in Drosophila oocytes.
Curr Biol
12
925-9
2002
Saccharomyces cerevisiae, Caenorhabditis elegans
Kitagawa, R; Law, E; Tang, L; Rose, AM
The Cdc20 homolog, FZY-1, and its interacting protein, IFY-1, are required for proper chromosome segregation in Caenorhabditis elegans.
Curr Biol
12
2118-23
2002
Caenorhabditis elegans, Saccharomyces cerevisiae
Mottram, JC; Helms, MJ; Coombs, GH; Sajid, M
Clan CD cysteine peptidases of parasitic protozoa.
Trends Parasitol
19
182-7
2003
protozoa
Leismann, O; Lehner, CF
Drosophila securin destruction involves a D-box and a KEN-box and promotes anaphase in parallel with Cyclin A degradation.
J Cell Sci
116
2453-60
2003
Drosophila, Saccharomyces cerevisiae, vertebrata
Herbert, M; Levasseur, M; Homer, H; Yallop, K; Murdoch, A; McDougall, A
Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1.
Nat Cell Biol
5
1023-5
2003
Mus musculus, Saccharomyces cerevisiae, Caenorhabditis elegans, Xenopus laevis
Rabitsch, KP; Gregan, J; Schleiffer, A; Javerzat, JP; Eisenhaber, F; Nasmyth, K
Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II.
Curr Biol
14
287-301
2004
Schizosaccharomyces pombe, Drosophila, Fungi, Drosophila melanogaster, Mammalia
Heidmann, D; Horn, S; Heidmann, S; Schleiffer, A; Nasmyth, K; Lehner, CF
The Drosophila meiotic kleisin C(2)M functions before the meiotic divisions.
Chromosoma
113
177-87
2004
Saccharomyces cerevisiae
Spinette, S; Lengauer, C; Mahoney, JA; Jallepalli, PV; Wang, Z; Casciola-Rosen, L; Rosen, A
Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation.
Cell Cycle
3
1638-44
2004
Scleroderma, Homo sapiens
Oelschlaegel, T; Schwickart, M; Matos, J; Bogdanova, A; Camasses, A; Havlis, J; Shevchenko, A; Zachariae, W
The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.
Cell
120
773-88
2005
Saccharomyces cerevisiae
Yu, R; Cruz-Soto, M; Li Calzi, S; Hui, H; Melmed, S
Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells.
J Endocrinol
191
45-53
2006
Mus musculus, Homo sapiens, Mus sp.
Minematsu, T; Egashira, N; Kajiya, H; Takei, M; Takekoshi, S; Itoh, Y; Tsukamoto, H; Itoh, J; Sanno, N; Teramoto, A; Osamura, RY
PTTG is a secretory protein in human pituitary adenomas and in mouse pituitary tumor cell lines.
Endocr Pathol
18
8-15
2007
Saccharomyces cerevisiae
Csizmok, V; Felli, IC; Tompa, P; Banci, L; Bertini, I
Structural and dynamic characterization of intrinsically disordered human securin by NMR spectroscopy.
J Am Chem Soc
130
16873-9
2008
Homo sapiens
Hsu, YH; Liao, LJ; Yu, CH; Chiang, CP; Jhan, JR; Chang, LC; Chen, YJ; Lou, PJ; Lin, JJ
Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human fibroblasts.
J Biol Chem
285
22630-8
2010
Homo sapiens
Wang, M; Tang, D; Wang, K; Shen, Y; Qin, B; Miao, C; Li, M; Cheng, Z
OsSGO1 maintains synaptonemal complex stabilization in addition to protecting centromeric cohesion during rice meiosis.
Plant J
67
583-94
2011
eukaryota
Kong, XY; Kissen, R; Bones, AM
Characterization of recombinant nitrile-specifier proteins (NSPs) of Arabidopsis thaliana: Dependency on Fe(II) ions and the effect of glucosinolate substrate and reaction conditions.
Phytochemistry
2012
Arabidopsis thaliana, Escherichia coli
Schvarzstein, M; Pattabiraman, D; Bembenek, JN; Villeneuve, AM
Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis.
Proc Natl Acad Sci U S A
110
E898-907
2013
Caenorhabditis elegans
Howard-Till, RA; Lukaszewicz, A; Novatchkova, M; Loidl, J
A single cohesin complex performs mitotic and meiotic functions in the protist tetrahymena.
PLoS Genet
9
e1003418
2013
Tetrahymena, Tetrahymena thermophila
Zhang, W; Wang, W; Liu, Z; Xie, Y; Wang, H; Mu, Y; Huang, Y; Feng, Y
Crystal structure of the Epithiospecifier Protein, ESP from Arabidopsis thaliana provides insights into its product specificity.
Biochem Biophys Res Commun
478
746-51
2016
Thlaspi arvense
Hu, B; Huang, W; Wang, R; Zang, W; Su, M; Li, H; Wang, H; Cao, B; Deng, D; Li, QQ; Jiang, J
High Rate of Detection of Human ESPL1-HBV S Fusion Gene in Patients With HBV-related Liver Cancer: A Chinese Case-Control Study.
Anticancer Res
40
245-252
2020
Homo sapiens, Hepatitis B virus
Baghdadi, JD; Brook, RH; Uslan, DZ; Needleman, J; Bell, DS; Cunningham, WE; Wong, MD
Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis.
JAMA Intern Med
180
707-716
2020
Homo sapiens
Weber, J; Kabakci, Z; Chaurasia, S; Brunner, E; Lehner, CF
Chromosome separation during Drosophila male meiosis I requires separase-mediated cleavage of the homolog conjunction protein UNO.
PLoS Genet
16
e1008928
2020
Drosophila
Dudaryk, R; Navas-Blanco, JR; Ferreira, TD; Epstein, RH
Failure to Clear Intermediate Lactate Levels in Ward Patients With Admission Blood Cultures Did Not Increase the Risk of Intensive Care Unit Transfer or In-Hospital Mortality: A Retrospective Cohort Study.
Cureus
13
e13326
2021
Homo sapiens
Bolaños-Villegas, P
The Role of Structural Maintenance of Chromosomes Complexes in Meiosis and Genome Maintenance: Translating Biomedical and Model Plant Research Into Crop Breeding Opportunities.
Front Plant Sci
12
659558
2021
Arabidopsis
Thomas, C; Wetherall, B; Levasseur, MD; Harris, RJ; Kerridge, ST; Higgins, JMG; Davies, OR; Madgwick, S
A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.
Nat Commun
12
4322
2021
Mus musculus
Mukherjee, M; Byrd, T; Brawley, VS; Bielamowicz, K; Li, XN; Merchant, F; Maitra, S; Sumazin, P; Fuller, G; Kew, Y; Sun, D; Powell, SZ; Ahmed, NM; Zhang, N; Pati, D
Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme.
J Neurooncol
119
27-35
2014
Homo sapiens, animal
Bai, X; Bembenek, JN
Protease dead separase inhibits chromosome segregation and RAB-11 vesicle trafficking.
Cell Cycle
1-16
2017
Caenorhabditis elegans
Jones, BL; Fontanini, D
Trypsin/alpha-amylase inhibitors inactivate the endogenous barley/malt serine endoproteinase SEP-1.
J Agric Food Chem
51
5803-14
2003
Hordeum vulgare
García-Luis, J; Machín, F
Mus81-Mms4 and Yen1 resolve a novel anaphase bridge formed by noncanonical Holliday junctions.
Nat Commun
5
5652
2014
Saccharomyces cerevisiae
Richie, CT; Bembenek, JN; Chestnut, B; Furuta, T; Schumacher, JM; Wallenfang, M; Golden, A
Protein phosphatase 5 is a negative regulator of separase function during cortical granule exocytosis in C. elegans.
J Cell Sci
124
2903-13
2011
Caenorhabditis elegans, Metazoa
Moschou, PN; Gutierrez-Beltran, E; Bozhkov, PV; Smertenko, A
Separase Promotes Microtubule Polymerization by Activating CENP-E-Related Kinesin Kin7.
Dev Cell
37
350-61
2016
Arabidopsis, plant
Agarwal, R; Cohen-Fix, O
Phosphorylation of the mitotic regulator Pds1/securin by Cdc28 is required for efficient nuclear localization of Esp1/separase.
Genes Dev
16
1371-82
2002
Saccharomyces cerevisiae
Haaß, W; Kleiner, H; Weiß, C; Haferlach, C; Schlegelberger, B; Müller, MC; Hehlmann, R; Hofmann, WK; Fabarius, A; Seifarth, W; , ; ,
Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.
PLoS One
10
e0129648
2015
Homo sapiens
Buonomo, SB; Clyne, RK; Fuchs, J; Loidl, J; Uhlmann, F; Nasmyth, K
Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin.
Cell
103
387-98
2000
Saccharomyces cerevisiae
Rappleye, CA; Tagawa, A; Lyczak, R; Bowerman, B; Aroian, RV
The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation.
Dev Cell
2
195-206
2002
Caenorhabditis elegans
Huang, X; Hatcher, R; York, JP; Zhang, P
Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells.
Mol Biol Cell
16
4725-32
2005
Mus musculus, Saccharomyces cerevisiae, Varanidae
Stemmann, O; Gorr, IH; Boos, D
Anaphase Topsy-Turvy: Cdk1 a Securin, Separase a CKI.
Cell Cycle
5
11-3
2006
vertebrata
Kumada, K; Yao, R; Kawaguchi, T; Karasawa, M; Hoshikawa, Y; Ichikawa, K; Sugitani, Y; Imoto, I; Inazawa, J; Sugawara, M; Yanagida, M; Noda, T
The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase.
J Cell Biol
172
835-46
2006
Mammalia, Mus musculus, Mus sp.
Holland, AJ; Taylor, SS
Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction.
J Cell Sci
119
3325-36
2006
Homo sapiens
Holland, AJ; Taylor, SS
Many faces of separase regulation.
SEB Exp Biol Ser
59
99-112
2008
Saccharomyces cerevisiae
Xu, J; Wang, M; Gao, X; Hu, B; Du, Y; Zhou, J; Tian, X; Huang, X
Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis.
PLoS One
6
e18763
2011
Mus musculus, Mus sp.
Zhang, N; Scorsone, K; Ge, G; Kaffes, CC; Dobrolecki, LE; Mukherjee, M; Lewis, MT; Berg, S; Stephan, CC; Pati, D
Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy.
J Biomol Screen
2014
Homo sapiens, Mus musculus, Mus sp.
Finetti, P; Guille, A; Adelaide, J; Birnbaum, D; Chaffanet, M; Bertucci, F
ESPL1 is a candidate oncogene of luminal B breast cancers.
Breast Cancer Res Treat
147
51-9
2014
Mus musculus
Mitchell, DM; Uehlein-Klebanow, LR; Bembenek, JN
Protease-dead separase is dominant negative in the C. elegans embryo.
PLoS One
9
e108188
2014
Caenorhabditis elegans
Müller, S
Linking Separase to Microtubule Dynamics.
Dev Cell
37
295-6
2016
Arabidopsis
Gurvits, N; Löyttyniemi, E; Nykänen, M; Kuopio, T; Kronqvist, P; Talvinen, K
Separase is a marker for prognosis and mitotic activity in breast cancer.
Br J Cancer
2017
Homo sapiens
Cucco, F; Palumbo, E; Camerini, S; D'Alessio, B; Quarantotti, V; Casella, ML; Rizzo, IM; Cukrov, D; Delia, D; Russo, A; Crescenzi, M; Musio, A
Separase prevents genomic instability by controlling replication fork speed.
Nucleic Acids Res
46
267-278
2018
Homo sapiens
Melesse, M; Bembenek, JN; Zhulin, IB
Conservation of the separase regulatory domain.
Biol Direct
13
7
2018
Caenorhabditis elegans, vertebrata, Metazoa, Nematodes
Rhee, C; Filbin, MR; Massaro, AF; Bulger, AL; McEachern, D; Tobin, KA; Kitch, BT; Thurlo-Walsh, B; Kadar, A; Koffman, A; Pande, A; Hamad, Y; Warren, DK; Jones, TM; O'Brien, C; Anderson, DJ; Wang, R; Klompas, M; ,
Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study.
Crit Care Med
46
1585-1591
2018
Homo sapiens
Barbash, IJ; Davis, B; Kahn, JM
National Performance on the Medicare SEP-1 Sepsis Quality Measure.
Crit Care Med
2018
Homo sapiens
Whitfield, PL; Ratliff, PD; Lockhart, LL; Andrews, D; Komyathy, KL; Sloan, MA; Leslie, JC; Judd, WR
Implementation of an adult code sepsis protocol and its impact on SEP-1 core measure perfect score attainment in the ED.
Am J Emerg Med
2019
Homo sapiens
Henschke, L; Frese, M; Hellmuth, S; Marx, A; Stemmann, O; Mayer, TU
Identification of Bioactive Small Molecule Inhibitors of Separase.
ACS Chem Biol
14
2155-2159
2019
Homo sapiens
Rosen, LE; Klebba, JE; Asfaha, JB; Ghent, CM; Campbell, MG; Cheng, Y; Morgan, DO
Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site.
Nat Commun
10
5189
2019
Homo sapiens
Miller, J; Hall, B; Wilson, K; Cobian, J
Impact of SEP-1 on broad-spectrum combination antibiotic therapy in the emergency department.
Am J Emerg Med
2020
Homo sapiens
Wang, J; Strich, JR; Applefeld, WN; Sun, J; Cui, X; Natanson, C; Eichacker, PQ
Driving blind: instituting SEP-1 without high quality outcomes data.
J Thorac Dis
12
S22-S36
2020
Homo sapiens
Jeong, PY; Kumar, A; Joshi, PM; Rothman, JH
Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death.
Sci Rep
10
6159
2020
Caenorhabditis elegans
Hellmuth, S; Gómez-H, L; Pendás, AM; Stemmann, O
Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2.
Nature
580
536-541
2020
Homo sapiens
Li, J; Zhang, HY; Wang, F; Sun, QY; Qian, WP
The Cyclin B2/CDK1 Complex Conservatively Inhibits Separase Activity in Oocyte Meiosis II.
Front Cell Dev Biol
9
648053
2021
Mus musculus
Liu, Z; Lian, X; Zhang, X; Zhu, Y; Zhang, W; Wang, J; Wang, H; Liu, B; Ren, Z; Zhang, M; Liu, M; Gao, Y
ESPL1 Is a Novel Prognostic Biomarker Associated With the Malignant Features of Glioma.
Front Genet
12
666106
2021
Homo sapiens
Hornig, NC; Uhlmann, F
Preferential cleavage of chromatin-bound cohesin after targeted phosphorylation by Polo-like kinase.
EMBO J
23
3144-53
2004
Saccharomyces cerevisiae
Rahal, R; Amon, A
The polo-like kinase Cdc5 interacts with FEAR network components and Cdc14.
Cell Cycle
7
3262-72
2008
Saccharomyces cerevisiae
Zhang, N; Panigrahi, AK; Mao, Q; Pati, D
Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion.
J Biol Chem
286
41826-37
2011
Saccharomyces cerevisiae
Waizenegger, IC; Hauf, S; Meinke, A; Peters, JM
Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase.
Cell
103
399-410
2000
Xenopus, Saccharomyces cerevisiae, vertebrata, Homo sapiens
Rao, H; Uhlmann, F; Nasmyth, K; Varshavsky, A
Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability.
Nature
410
955-9
2001
Saccharomyces cerevisiae, Ursidae
Aravind, L; Koonin, EV
Classification of the caspase-hemoglobinase fold: detection of new families and implications for the origin of the eukaryotic separins.
Proteins
46
355-67
2002
Anabaena, Bacteria, eukaryota, Mesorhizobium, Myxococcus, Nostoc sp., Streptomyces
Romero, F; Gil-Bernabé, AM; Sáez, C; Japón, MA; Pintor-Toro, JA; Tortolero, M
Securin is a target of the UV response pathway in mammalian cells.
Mol Cell Biol
24
2720-33
2004
Homo sapiens
Giménez-Abián, JF; Sumara, I; Hirota, T; Hauf, S; Gerlich, D; de la Torre, C; Ellenberg, J; Peters, JM
Regulation of sister chromatid cohesion between chromosome arms.
Curr Biol
14
1187-93
2004
vertebrata
Torres-Rosell, J; MachÃn, F; Aragón, L
Cdc14 and the temporal coordination between mitotic exit and chromosome segregation.
Cell Cycle
4
109-12
2005
Saccharomyces cerevisiae
Higuchi, T; Uhlmann, F
Stabilization of microtubule dynamics at anaphase onset promotes chromosome segregation.
Nature
433
171-6
2005
Saccharomyces cerevisiae
Nigg, EA
Centrosome duplication: of rules and licenses.
Trends Cell Biol
17
215-21
2007
Caenorhabditis elegans, animal
Rubinek, T; Chesnokova, V; Wolf, I; Wawrowsky, K; Vlotides, G; Melmed, S
Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells.
Am J Physiol Cell Physiol
293
C1082-92
2007
Mus sp.
Tóth, A; Queralt, E; Uhlmann, F; Novák, B
Mitotic exit in two dimensions.
J Theor Biol
248
560-73
2007
eukaryota, Saccharomyces cerevisiae, Homo sapiens
Patel, H; Gordon, MY
Abnormal centrosome-centriole cycle in chronic myeloid leukaemia?
Br J Haematol
146
408-17
2009
Homo sapiens
López-Avilés, S; Uhlmann, F
Cell cycle: the art of multi-tasking.
Curr Biol
20
R101-3
2010
Nematoda, Caenorhabditis elegans
Mirchenko, L; Uhlmann, F
Sli15(INCENP) dephosphorylation prevents mitotic checkpoint reengagement due to loss of tension at anaphase onset.
Curr Biol
20
1396-401
2010
Saccharomyces cerevisiae, Homo sapiens
McAleenan, A; Clemente-Blanco, A; Cordon-Preciado, V; Sen, N; Esteras, M; Jarmuz, A; Aragón, L
Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin.
Nature
493
250-4
2013
Saccharomyces cerevisiae
Eapen, VV; Haber, JE
DNA damage signaling triggers the cytoplasm-to-vacuole pathway of autophagy to regulate cell cycle progression.
Autophagy
9
440-1
2013
Punctum, Saccharomyces cerevisiae
Tedeschi, A; Wutz, G; Huet, S; Jaritz, M; Wuensche, A; Schirghuber, E; Davidson, IF; Tang, W; Cisneros, DA; Bhaskara, V; Nishiyama, T; Vaziri, A; Wutz, A; Ellenberg, J; Peters, JM
Wapl is an essential regulator of chromatin structure and chromosome segregation.
Nature
501
564-8
2013
Mus musculus
Baro, B; Rodriguez-Rodriguez, JA; Calabria, I; Hernáez, ML; Gil, C; Queralt, E
Dual Regulation of the mitotic exit network (MEN) by PP2A-Cdc55 phosphatase.
PLoS Genet
9
e1003966
2013
Saccharomyces cerevisiae, Homo sapiens
Boland, A; Martin, TG; Zhang, Z; Yang, J; Bai, XC; Chang, L; Scheres, SH; Barford, D
Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.
Nat Struct Mol Biol
24
414-418
2017
Caenorhabditis elegans
Lianga, N; Doré, C; Kennedy, EK; Yeh, E; Williams, EC; Fortinez, CM; Wang, A; Bloom, KS; Rudner, AD
Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset.
PLoS Genet
14
e1007029
2018
Saccharomyces cerevisiae
Zhang, T; Lim, HH; Cheng, CS; Surana, U
Deficiency of centromere-associated protein Slk19 causes premature nuclear migration and loss of centromeric elasticity.
J Cell Sci
119
519-31
2006
Ursidae
Cabral, G; Sans, SS; Cowan, CR; Dammermann, A
Multiple mechanisms contribute to centriole separation in C. elegans.
Curr Biol
23
1380-7
2013
Caenorhabditis elegans, vertebrata
Hellmuth, S; Stemmann, O
Separase-triggered apoptosis enforces minimal length of mitosis.
Nature
580
542-547
2020
Homo sapiens
Luo, S; Tong, L
Structure and Function of the Separase-Securin Complex.
Subcell Biochem
96
217-232
2021
eukaryota, Saccharomyces cerevisiae, Metazoa
Gui, T; Yao, C; Jia, B; Shen, K
Identification and analysis of genes associated with epithelial ovarian cancer by integrated bioinformatics methods.
PLoS One
16
e0253136
2021
Homo sapiens
Yanagida, M
Basic mechanism of eukaryotic chromosome segregation.
Philos Trans R Soc Lond B Biol Sci
360
609-21
2005
Bacteria, eukaryota
Li, S; Yue, Z; Tanaka, TU
Smc3 Deacetylation by Hos1 Facilitates Efficient Dissolution of Sister Chromatid Cohesion during Early Anaphase.
Mol Cell
68
605-614.e4
2017
Saccharomyces cerevisiae
Prinzhorn, W; Stehle, M; Kleiner, H; Ruppenthal, S; Müller, MC; Hofmann, WK; Fabarius, A; Seifarth, W
c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia.
Biomark Res
4
5
2016
Homo sapiens, clinical samples
Hellmuth, S; Böttger, F; Pan, C; Mann, M; Stemmann, O
PP2A delays APC/C-dependent degradation of separase-associated but not free securin.
EMBO J
33
1134-47
2014
Homo sapiens
Khondker, S; Kajjo, S; Chandler-Brown, D; Skotheim, J; Rudner, A; Ikui, A
PP2ACdc55 dephosphorylates Pds1 and inhibits spindle elongation in S. cerevisiae.
J Cell Sci
133
2020
Saccharomyces cerevisiae
Tomson, BN; Rahal, R; Reiser, V; Monje-Casas, F; Mekhail, K; Moazed, D; Amon, A
Regulation of Spo12 phosphorylation and its essential role in the FEAR network.
Curr Biol
19
449-60
2009
Saccharomyces cerevisiae
Farina, AR; Tacconelli, A; Cappabianca, L; Cea, G; Panella, S; Chioda, A; Romanelli, A; Pedone, C; Gulino, A; Mackay, AR
The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability.
Mol Cell Biol
29
4812-30
2009
Homo sapiens
Warner, SL; Gray, PJ; Von Hoff, DD
Tubulin-associated drug targets: Aurora kinases, Polo-like kinases, and others.
Semin Oncol
33
436-48
2006
Homo sapiens
Vázquez-Novelle, MD; Sansregret, L; Dick, AE; Smith, CA; McAinsh, AD; Gerlich, DW; Petronczki, M
Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase.
Curr Biol
24
638-45
2014
Homo sapiens
Játiva, S; Calabria, I; Moyano-Rodriguez, Y; Garcia, P; Queralt, E
Cdc14 activation requires coordinated Cdk1-dependent phosphorylation of Net1 and PP2A-Cdc55 at anaphase onset.
Cell Mol Life Sci
76
3601-3620
2019
eukaryota, Saccharomyces cerevisiae, Homo sapiens
Stemmann, O; Zou, H; Gerber, SA; Gygi, SP; Kirschner, MW
Dual inhibition of sister chromatid separation at metaphase.
Cell
107
715-26
2001
Xenopus
Zhou, Y; Mehta, KR; Choi, AP; Scolavino, S; Zhang, X
DNA damage-induced inhibition of securin expression is mediated by p53.
J Biol Chem
278
462-70
2003
Homo sapiens
Gerber, SA; Rush, J; Stemman, O; Kirschner, MW; Gygi, SP
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS.
Proc Natl Acad Sci U S A
100
6940-5
2003
Saccharomyces cerevisiae, Homo sapiens
Ross, KE; Cohen-Fix, O
A role for the FEAR pathway in nuclear positioning during anaphase.
Dev Cell
6
729-35
2004
Saccharomyces cerevisiae
Lee, JY; Dej, KJ; Lopez, JM; Orr-Weaver, TL
Control of centromere localization of the MEI-S332 cohesion protection protein.
Curr Biol
14
1277-83
2004
Homo sapiens, Drosophila
Pati, D; Haddad, BR; Haegele, A; Thompson, H; Kittrell, FS; Shepard, A; Montagna, C; Zhang, N; Ge, G; Otta, SK; McCarthy, M; Ullrich, RL; Medina, D
Hormone-induced chromosomal instability in p53-null mammary epithelium.
Cancer Res
64
5608-16
2004
Homo sapiens, Mus musculus
Tfelt-Hansen, J; Kanuparthi, D; Chattopadhyay, N
The emerging role of pituitary tumor transforming gene in tumorigenesis.
Clin Med Res
4
130-7
2006
Homo sapiens
Sullivan, M; Holt, L; Morgan, DO
Cyclin-specific control of ribosomal DNA segregation.
Mol Cell Biol
28
5328-36
2008
Saccharomyces cerevisiae
de Carvalho, CE; Zaaijer, S; Smolikov, S; Gu, Y; Schumacher, JM; Colaiácovo, MP
LAB-1 antagonizes the Aurora B kinase in C. elegans.
Genes Dev
22
2869-85
2008
Caenorhabditis elegans
McGuinness, BE; Anger, M; Kouznetsova, A; Gil-Bernabé, AM; Helmhart, W; Kudo, NR; Wuensche, A; Taylor, S; Hoog, C; Novak, B; Nasmyth, K
Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint.
Curr Biol
19
369-80
2009
Homo sapiens
La Starza, R; Brandimarte, L; Pierini, V; Nofrini, V; Gorello, P; Crescenzi, B; Berchicci, L; Matteucci, C; Romoli, S; Beacci, D; Rosati, R; Martelli, MF; Mecucci, C
A NUP98-positive acute myeloid leukemia with a t(11;12)(p15;q13) without HOXC cluster gene involvement.
Cancer Genet Cytogenet
193
109-11
2009
Homo sapiens
Xu, Z; Cetin, B; Anger, M; Cho, US; Helmhart, W; Nasmyth, K; Xu, W
Structure and function of the PP2A-shugoshin interaction.
Mol Cell
35
426-41
2009
Saccharomyces cerevisiae, Homo sapiens
Kim, HS; Baek, KH; Ha, GH; Lee, JC; Kim, YN; Lee, J; Park, HY; Lee, NR; Lee, H; Cho, Y; Lee, CW
The hsSsu72 phosphatase is a cohesin-binding protein that regulates the resolution of sister chromatid arm cohesion.
EMBO J
29
3544-57
2010
vertebrata
Beckouët, F; Hu, B; Roig, MB; Sutani, T; Komata, M; Uluocak, P; Katis, VL; Shirahige, K; Nasmyth, K
An Smc3 acetylation cycle is essential for establishment of sister chromatid cohesion.
Mol Cell
39
689-99
2010
Saccharomyces cerevisiae
Gutiérrez-Caballero, C; Cebollero, LR; Pendás, AM
Shugoshins: from protectors of cohesion to versatile adaptors at the centromere.
Trends Genet
28
351-60
2012
eukaryota, vertebrata
Cundell, MJ; Bastos, RN; Zhang, T; Holder, J; Gruneberg, U; Novak, B; Barr, FA
The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation.
Mol Cell
52
393-405
2013
Saccharomyces cerevisiae, Homo sapiens, Metazoa
Rattani, A; Vinod, PK; Godwin, J; Tachibana-Konwalski, K; Wolna, M; Malumbres, M; Novák, B; Nasmyth, K
Dependency of the spindle assembly checkpoint on cdk1 renders the anaphase transition irreversible.
Curr Biol
24
630-7
2014
Mus musculus
Nam, HJ; van Deursen, JM
Cyclin B2 and p53 control proper timing of centrosome separation.
Nat Cell Biol
16
538-49
2014
Homo sapiens, Mus musculus
Aaronson, EL; Filbin, MR; Brown, DF; Tobin, K; Mort, EA
New Mandated Centers for Medicare and Medicaid Services Requirements for Sepsis Reporting: Caution from the Field.
J Emerg Med
52
109-116
2017
Homo sapiens
Venkatesh, AK; Slesinger, T; Whittle, J; Osborn, T; Aaronson, E; Rothenberg, C; Tarrant, N; Goyal, P; Yealy, DM; Schuur, JD
Preliminary Performance on the New CMS Sepsis-1 National Quality Measure: Early Insights From the Emergency Quality Network (E-QUAL).
Ann Emerg Med
2017
collection
Septimus, EJ; Coopersmith, CM; Whittle, J; Hale, CP; Fishman, NO; Kim, TJ
Sepsis National Hospital Inpatient Quality Measure (SEP-1): Multistakeholder Work Group Recommendations for Appropriate Antibiotics for the Treatment of Sepsis.
Clin Infect Dis
65
1565-1569
2017
Homo sapiens
Han, X; Edelson, DP; Snyder, A; Pettit, N; Sokol, S; Barc, C; Howell, MD; Churpek, MM
Implications of Centers for Medicare & Medicaid Services Severe Sepsis and Septic Shock Early Management Bundle and Initial Lactate Measurement on the Management of Sepsis.
Chest
154
302-308
2018
Homo sapiens
Wang, D; Zhu, H; Guo, M; Fan, X; Hu, S; Yan, K; Sun, J; Wang, J; Li, M; Xiao, H; Liu, Z
Expression and prognostic value of cell-cycle-associated genes in gastric adenocarcinoma.
BMC Gastroenterol
18
81
2018
Homo sapiens
Buechler, SA; Gökmen-Polar, Y; Badve, SS
EarlyR signature predicts response to neoadjuvant chemotherapy in breast cancer.
Breast
43
74-80
2019
Homo sapiens
Henry, KE; Hager, DN; Osborn, TM; Wu, AW; Saria, S
Comparison of Automated Sepsis Identification Methods and Electronic Health Record-based Sepsis Phenotyping: Improving Case Identification Accuracy by Accounting for Confounding Comorbid Conditions.
Crit Care Explor
1
e0053
2019
Homo sapiens
Pakyz, AL; Orndahl, CM; Johns, A; Harless, DW; Morgan, DJ; Bearman, G; Hohmann, SF; Stevens, MP
Impact of the Centers for Medicare and Medicaid Services Sepsis Core Measure on Antibiotic Use.
Clin Infect Dis
2020
Homo sapiens
Lasater, KB; Sloane, DM; McHugh, MD; Cimiotti, JP; Riman, KA; Martin, B; Alexander, M; Aiken, LH
Evaluation of hospital nurse-to-patient staffing ratios and sepsis bundles on patient outcomes.
Am J Infect Control
49
868-873
2021
Homo sapiens
Mengoli, V; Jonak, K; Lyzak, O; Lamb, M; Lister, LM; Lodge, C; Rojas, J; Zagoriy, I; Herbert, M; Zachariae, W
Deprotection of centromeric cohesin at meiosis II requires APC/C activity but not kinetochore tension.
EMBO J
40
e106812
2021
Saccharomyces cerevisiae
Townsend, SR; Phillips, GS; Duseja, R; Tefera, L; Cruikshank, D; Dickerson, R; Nguyen, HB; Schorr, CA; Levy, MM; Dellinger, RP; Conway, WA; Browner, WS; Rivers, EP
Effects of Compliance With the Early Management Bundle (SEP-1) on Mortality Changes Among Medicare Beneficiaries With Sepsis: A Propensity Score Matched Cohort Study.
Chest
2021
collection
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