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6'-deoxy bleomycin A2 + H2O
6'-deoxy deamido bleomycin A2 + NH3
recombinant enzyme shows rapid and efficient hydrolysis of all bleomycins tested, exhibiting a superior catalytic efficiency for bleomycin B2
-
-
?
6'-deoxy bleomycin Z + H2O
6'-deoxy deamido bleomycin Z + NH3
recombinant enzyme shows rapid and efficient hydrolysis of all bleomycins tested, exhibiting a superior catalytic efficiency for bleomycin B2
-
-
?
6'-deoxy tallysomycin H1 + H2O
? + NH3
-
-
-
?
bleomycin A2 + H2O
deamido bleomycin A2 + NH3
bleomycin B2 + H2O
deamido bleomycin B2 + NH3
bleomycin Z + H2O
deamido bleomycin Z + NH3
recombinant enzyme shows rapid and efficient hydrolysis of all bleomycins tested, exhibiting a superior catalytic efficiency for bleomycin B2
-
-
?
tallysomycin H1 + H2O
? + NH3
-
-
-
?
bleomycin + H2O
deamido-bleomycin
bleomycin A2 + H2O
?
-
preferred to bleomycin B
-
-
?
bleomycin B2 + H2O
?
-
-
-
-
?
citrulline-4-methylcoumarin 7-amide + H2O
citrulline + 7-amino-4-methylcoumarin
-
-
-
-
?
citrulline-7-amido-4-methylcoumarin + H2O
citrulline + 7-amino-4-methylcoumarin
-
-
-
-
?
citrulline-beta-naphthylamide + H2O
citrulline + beta-naphthylamine
-
-
-
-
?
deiminated filaggrin + H2O
?
Glu-4-methylcoumarin 7-amide + H2O
Glu + 7-amino-4-methylcoumarin
-
-
-
-
?
huntingtin + H2O
?
-
the enzyme is involved in a specific cleavage step at the N-terminal fragment cp-2 site of huntingtin
-
-
?
additional information
?
-
bleomycin A2 + H2O
deamido bleomycin A2 + NH3
the enzyme hydrolyzes bleomycins into the biologically inactive deamido bleomycins
-
-
?
bleomycin A2 + H2O
deamido bleomycin A2 + NH3
recombinant enzyme shows rapid and efficient hydrolysis of all bleomycins tested, exhibiting a superior catalytic efficiency for bleomycin B2
-
-
?
bleomycin B2 + H2O
deamido bleomycin B2 + NH3
the enzyme hydrolyzes bleomycins into the biologically inactive deamido bleomycins
-
-
?
bleomycin B2 + H2O
deamido bleomycin B2 + NH3
recombinant enzyme shows rapid and efficient hydrolysis of all bleomycins tested, exhibiting a superior catalytic efficiency for bleomycin B2
-
-
?
bleomycin + H2O
?
-
-
-
-
?
bleomycin + H2O
?
-
bleomycin is a cytotoxic agent inducing pneumonitis, detoxification reaction
-
-
?
bleomycin + H2O
?
-
detoxification reaction, high enzyme expression level leads to resistance against the drug
-
-
?
bleomycin + H2O
deamido-bleomycin
-
-
-
?
bleomycin + H2O
deamido-bleomycin
-
-
-
-
?
bleomycin + H2O
deamido-bleomycin
-
bleomycin B2
-
?
bleomycin + H2O
deamido-bleomycin
-
bleomycin B2
-
-
?
bleomycin + H2O
deamido-bleomycin
-
bleomycin A2
-
?
bleomycin + H2O
deamido-bleomycin
-
bleomycin A2
-
?
deiminated filaggrin + H2O
?
-
neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids
-
-
?
deiminated filaggrin + H2O
?
-
recombinant human filaggrin is a component of the cornified cell envelope and the precursor of free amino acids acting as a natural moisturizing factor in the stratum corneum. Profilaggrin is synthesized as a large, extremely insoluble phosphoprotein. Deimination is critical for the degradation of filaggrin into free amino acids, deimination of filaggrin is catalyzed by murine PAD3
-
-
?
additional information
?
-
bleomycin hydrolase as an essential component of chemotherapy regimens for disseminated testicular germ-cell cancer analyzed, study on relation of single nucleotide polymorphism (SNP) A1450G of the bleomycin hydrolase gene with survival according to genotype analyzed
-
-
?
additional information
?
-
-
bleomycin hydrolase as an essential component of chemotherapy regimens for disseminated testicular germ-cell cancer analyzed, study on relation of single nucleotide polymorphism (SNP) A1450G of the bleomycin hydrolase gene with survival according to genotype analyzed
-
-
?
additional information
?
-
-
substrate specificity, overview
-
-
?
additional information
?
-
-
the enzyme exhibits protection against homocysteine toxicity, role and mechanisms of bleomycin hydrolase, overview
-
-
?
additional information
?
-
-
the substrate specificity is controlled by the opening of the barrel structure and the positioning of the enzyme's C-terminus in the active site as opposed to the features of the substrate, mechanism, overview
-
-
?
additional information
?
-
-
bleomycin hydrolase is a neutral cysteine protease, the enzyme releases various amino acids except Pro from beta-naphthylamide derivatives and hydrolyzed citrulline-beta-naphthylamide most effectively, overview
-
-
?
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Acute Coronary Syndrome
Association of homocysteine thiolactonase activity and PON1 polymorphisms with the severity of acute coronary syndrome.
Adenocarcinoma
Purification of bleomycin hydrolase with a monoclonal antibody and its characterization.
Adenoma
Immunohistochemical detection of prolactin in clinically non-functioning pituitary adenomas.
Alzheimer Disease
Analysis of association between bleomycin hydrolase and apolipoprotein E polymorphism in Alzheimer's disease.
Alzheimer Disease
Association between bleomycin hydrolase and Alzheimer's disease in caucasians.
Alzheimer Disease
Astrogliosis and behavioral changes in mice lacking the neutral cysteine protease bleomycin hydrolase.
Alzheimer Disease
Bleomycin hydrolase immunoreactivity in senile plaque in the brains of patients with Alzheimer's disease.
Alzheimer Disease
Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease.
Alzheimer Disease
Confirmation of the association between bleomycin hydrolase genotype and Alzheimer's disease.
Alzheimer Disease
Genetic risk factors of sporadic Alzheimer's disease among Chinese in Taiwan.
Alzheimer Disease
Human bleomycin hydrolase regulates the secretion of amyloid precursor protein.
Alzheimer Disease
Lack of association between bleomycin hydrolase gene polymorphism and Alzheimer's disease in Japanese people.
Alzheimer Disease
Reduced Homocysteine-Thiolactonase Activity in Alzheimer's Disease.
Alzheimer Disease
Reduced homocysteine-thiolactonase activity in Alzheimer's disease.
Alzheimer Disease
Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains.
Atherosclerosis
Association of paraoxonase 55 and 192 gene polymorphisms on serum homocysteine concentrations in preeclampsia.
Atherosclerosis
Decreased paraoxonase 1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease.
Atherosclerosis
Genetic determinants of homocysteine thiolactonase activity in humans: implications for atherosclerosis.
Atherosclerosis
Inverse correlation of serum paraoxonase and homocysteine thiolactonase activities and antioxidant capacity of high-density lipoprotein with the severity of cardiovascular disease in persons with type 2 diabetes mellitus.
Atherosclerosis
Investigation of the relationship between atherosclerosis and paraoxonase or homocysteine thiolactonase activity in patients with type 2 diabetes mellitus using a commercially available assay.
bleomycin hydrolase deficiency
Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease.
Breast Neoplasms
Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase.
Breast Neoplasms
Serum bioactive lactogenic hormone levels in women with familial breast cancer and their relatives.
Carcinoma
Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance.
Carcinoma
Potentiation of the cytotoxicity of peplomycin against Ehrlich ascites carcinoma by bleomycin hydrolase inhibitors.
Carcinoma
Purification of bleomycin hydrolase with a monoclonal antibody and its characterization.
Carcinoma, Hepatocellular
Identification of the bleomycin hydrolase gene as a methylated tumor suppressor gene in hepatocellular carcinoma using a novel triple-combination array method.
Cardiovascular Diseases
Inverse correlation of serum paraoxonase and homocysteine thiolactonase activities and antioxidant capacity of high-density lipoprotein with the severity of cardiovascular disease in persons with type 2 diabetes mellitus.
Chromosome Disorders
LRH-stimulated release of bioactive and immunoreactive LH in a patient with the XX male syndrome.
Coronary Artery Disease
Serum PON-1 Activity but not Q192R Polymorphism is Related to the Extent of Atherosclerosis.
Dementia
Polymorphisms of the human apolipoprotein E promoter and bleomycin hydrolase gene: risk factors for Alzheimer's dementia?
Dermatitis
A case of bleomycin-induced flagellate dermatitis: A case report.
Dermatitis, Atopic
Bleomycin hydrolase downregulation in lesional skin of adult atopic dermatitis patients is independent of FLG gene mutations.
Dermatitis, Atopic
Bleomycin Hydrolase Is Regulated Biphasically in a Differentiation- and Cytokine-dependent Manner: RELEVANCE TO ATOPIC DERMATITIS.
Dermatitis, Atopic
Seasonal variability of epidermal Bleomycin Hydrolase activity in healthy children and pediatric patients with atopic dermatitis.
Diabetes Mellitus
Inverse correlation of serum paraoxonase and homocysteine thiolactonase activities and antioxidant capacity of high-density lipoprotein with the severity of cardiovascular disease in persons with type 2 diabetes mellitus.
Diabetes Mellitus
Investigation of the relationship between atherosclerosis and paraoxonase or homocysteine thiolactonase activity in patients with type 2 diabetes mellitus using a commercially available assay.
Diabetes Mellitus
Relations of lysophosphatidylcholine in low-density lipoprotein with serum lipoprotein-associated phospholipase A2, paraoxonase and homocysteine thiolactonase activities in patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Inverse correlation of serum paraoxonase and homocysteine thiolactonase activities and antioxidant capacity of high-density lipoprotein with the severity of cardiovascular disease in persons with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Investigation of the relationship between atherosclerosis and paraoxonase or homocysteine thiolactonase activity in patients with type 2 diabetes mellitus using a commercially available assay.
Diabetes Mellitus, Type 2
Relations of lysophosphatidylcholine in low-density lipoprotein with serum lipoprotein-associated phospholipase A2, paraoxonase and homocysteine thiolactonase activities in patients with type 2 diabetes mellitus.
Diabetic Nephropathies
Evaluation of Paraoxonase, Arylesterase, and Homocysteine Thiolactonase Activities in Patients with Diabetes and Incipient Diabetes Nephropathy.
Diabetic Nephropathies
Relations of lysophosphatidylcholine in low-density lipoprotein with serum lipoprotein-associated phospholipase A2, paraoxonase and homocysteine thiolactonase activities in patients with type 2 diabetes mellitus.
Hodgkin Disease
Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance.
Hodgkin Disease
Effect of Bleomycin Hydrolase Gene Polymorphism on Late Pulmonary Complications of Treatment for Hodgkin Lymphoma.
Hyperhomocysteinemia
Bleomycin hydrolase and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis.
Hyperhomocysteinemia
Hyperhomocysteinemia and Bleomycin Hydrolase Modulate the Expression of Mouse Brain Proteins Involved in Neurodegeneration.
Hyperhomocysteinemia
Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease.
Hypersensitivity
BLH1 codes for a yeast thiol aminopeptidase, the equivalent of mammalian bleomycin hydrolase.
Hypertension
[Circadian blood pressure rhythm and its characterization in isolated systolic hypertension (ISH)]
Leukemia
Action of bleomycin is affected by bleomycin hydrolase but not by caveolin-1.
Leydig Cell Tumor
Circulatory half-life but not interaction with the lutropin/chorionic gonadotropin receptor is modulated by sulfation of bovine lutropin oligosaccharides.
Lymphoma
Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance.
Lymphoma
Histopathological and immunohistochemical study of atypical lymphoid hyperplasia and benign lymphoid hyperplasia of the stomach.
Malnutrition
Androgen receptor function during undernutrition.
Metabolic Syndrome
Modulation of paraoxonase 1 and protein N-homocysteinylation by leptin and the synthetic liver X receptor agonist T0901317 in the rat.
Neoplasms
Action of bleomycin is affected by bleomycin hydrolase but not by caveolin-1.
Neoplasms
Activated T-cell subsets in benign lymphoid hyperplasias and B-cell non-Hodgkin's lymphomas.
Neoplasms
Biochemical and cellular determinants of bleomycin cytotoxicity.
Neoplasms
Bleomycin hydrolase activity and cytotoxicity in human tumors.
Neoplasms
Breast Cancer-Derived Microvesicles Are the Source of Functional Metabolic Enzymes as Potential Targets for Cancer Therapy.
Neoplasms
Castleman's disease. Angiofollicular benign lymph-node hyperplasia. Radiological features in the differential diagnosis of vascular tumours of the pelvis.
Neoplasms
Cellular resistance to bleomycin in Saccharomyces cerevisiae is not affected by changes in bleomycin hydrolase levels.
Neoplasms
Circulatory half-life but not interaction with the lutropin/chorionic gonadotropin receptor is modulated by sulfation of bovine lutropin oligosaccharides.
Neoplasms
Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance.
Neoplasms
Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease.
Neoplasms
Cys102 and His398 are required for bleomycin-inactivating activity but not for hexamer formation of yeast bleomycin hydrolase.
Neoplasms
Downsizing the BAD BH3 peptide to small constrained ?-helices with improved ligand efficiency.
Neoplasms
Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients.
Neoplasms
Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase.
Neoplasms
Identification of the bleomycin hydrolase gene as a methylated tumor suppressor gene in hepatocellular carcinoma using a novel triple-combination array method.
Neoplasms
Immunohistochemical detection of prolactin in clinically non-functioning pituitary adenomas.
Neoplasms
Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease.
Neoplasms
Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure.
Neoplasms
Osteosarcoma of limb bones: a clinical, radiological and histopathological diagnostic agreement at Black Lion Teaching Hospital, Ethiopia.
Neoplasms
Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer.
Neoplasms
Yeast bleomycin hydrolase is a DNA-binding cysteine protease. Identification, purification, biochemical characterization.
Neoplasms
Yeast cysteine proteinase gene ycp1 induces resistance to bleomycin in mammalian cells.
Neoplasms, Germ Cell and Embryonal
Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients.
Neoplasms, Germ Cell and Embryonal
Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer.
Neurodegenerative Diseases
[Apolipoprotein E and bleomycin hydrolase. Polymorphisms: association with neurodegenerative diseases]
Neurofibromatoses
Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase.
Neurofibromatosis 1
Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase.
Osteopetrosis
Chicken strain G-B1 exhibits a relative resistance to avian osteopetrosis.
Pre-Eclampsia
Association of paraoxonase 55 and 192 gene polymorphisms on serum homocysteine concentrations in preeclampsia.
Pulmonary Fibrosis
Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice.
Pulmonary Fibrosis
Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase.
Renal Insufficiency
Relationship between serum paraoxonase and homocysteine thiolactonase activity, adipokines, and asymmetric dimethyl arginine concentrations in renal transplant patients.
Retinoblastoma
Subconjunctival carboplatin therapy and cryotherapy in the treatment of transgenic murine retinoblastoma.
Sarcoma 180
Purification of bleomycin hydrolase with a monoclonal antibody and its characterization.
Spinal Stenosis
Comparison of unilateral hemilaminotomy and bilateral hemilaminotomy according to dural sac area in lumbar spinal stenosis.
Stroke
Echogenicity variations from porcine blood I: the "bright collapsing ring" under pulsatile flow.
Tachycardia
Autonomic reflexes in borderline hypertensives.
Thrombocytopenia
Comparison of the platelet pro-aggregatory effect of conventional unfractionated heparins and a low molecular weight heparin fraction (CY 222).
Thrombosis
Relationship between thiolactonase activity and hyperhomocysteinemia according to MTHFR gene polymorphism in Tunisian Behçet's disease patients.
Turner Syndrome
LRH-stimulated release of bioactive and immunoreactive LH in a patient with the XX male syndrome.
Uterine Cervical Neoplasms
Action of bleomycin is affected by bleomycin hydrolase but not by caveolin-1.
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Lefterov, I.M.; Koldamova, R.P.; King, J.; Lazo, J.S.
The C-terminus of human bleomycin hydrolase is required for protection against bleomycin-induced chromosomal damage
Mutat. Res.
421
1-7
1998
Homo sapiens
brenda
Sebti, S.M.; Mignano, J.E.; Jani, J.P.; Srimatkandada, S.; Lazo, J.S.
Bleomycin hydrolase: molecular cloning, sequencing, and biochemical studies reveal membership in the cysteine proteinase family
Biochemistry
28
6544-6548
1989
Gallus gallus, Homo sapiens, Lithobates catesbeianus, Mus musculus, Oryctolagus cuniculus, Papio hamadryas, Rattus norvegicus
brenda
Broemme, D.; Rossi, A.B.; Smeekens, S.P.; Anderson, D.C.; Payan, D.G.
Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization
Biochemistry
35
6706-6714
1996
Homo sapiens
brenda
O'Farrel, P.; Gonzalez, F.; Zheng, W.; Johnston, S.A.; Joshua-Tor, L.
Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease
Structure Fold. Des.
15
619-627
1999
Homo sapiens
-
brenda
Lazo, J.S.; Boland, C.J.; Schwartz, P.E.
Bleomycin hydrolase activity and cytotoxicity in human tumors
Cancer Res.
42
4026-4031
1982
Homo sapiens
brenda
Lefterov, I.M.; Koldamova, R.P.; Lefterova, M.; Schwartz, D-R.; Lazo, J.S.
Cysteine 73 in bleomycin hydrolase is critical for amyloid precursor protein processing
Biochem. Biophys. Res. Commun.
283
994-999
2001
Homo sapiens
brenda
Lefterov, I.M.; Koldamova, R.P.; Lazo, J.S.
Human bleomycin hydrolase regulates the secretion of amyloid precursor protein
FASEB J.
14
1837-1847
2000
Homo sapiens
brenda
Joshua-Tor, L.; Johnston, S.A.
Bleomycin hydrolase
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press
2
1197-1201
2004
Saccharomyces cerevisiae, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Streptomyces verticillus
-
brenda
Zimny, J.; Sikora, M.; Guranowski, A.; Jakubowski, H.
Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase
J. Biol. Chem.
281
22485-22492
2006
Homo sapiens, Saccharomyces cerevisiae
brenda
Nuver, J.; Lutke Holzik, M.F.; van Zweeden, M.; Hoekstra, H.J.; Meijer, C.; Suurmeijer, A.J.; Groen, H.J.; Hofstra, R.M.; Sluiter, W.J.; Groen, H.; Sleijfer, D.T.; Gietema, J.A.
Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients
Pharmacogenet. Genomics
15
399-405
2005
Homo sapiens
brenda
de Haas, E.C.; Zwart, N.; Meijer, C.; Nuver, J.; Boezen, H.M.; Suurmeijer, A.J.; Hoekstra, H.J.; van der Steege, G.; Sleijfer, D.T.; Gietema, J.A.
Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer
J. Clin. Oncol.
26
1817-1823
2008
Homo sapiens (Q13867), Homo sapiens
brenda
Kamata, Y.; Taniguchi, A.; Yamamoto, M.; Nomura, J.; Ishihara, K.; Takahara, H.; Hibino, T.; Takeda, A.
Neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids
J. Biol. Chem.
284
12829-12836
2009
Homo sapiens, Rattus norvegicus
brenda
Ratovitski, T.; Chighladze, E.; Waldron, E.; Hirschhorn, R.R.; Ross, C.A.
Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin
J. Biol. Chem.
286
12578-12589
2011
Homo sapiens
brenda
Kamata, Y.; Yamamoto, M.; Kawakami, F.; Tsuboi, R.; Takeda, A.; Ishihara, K.; Hibino, T.
Bleomycin hydrolase is regulated biphasically in a differentiation- and cytokine-dependent manner: relevance to atopic dermatitis
J. Biol. Chem.
286
8204-8212
2011
Homo sapiens
brenda
Chen, J.; Chen, Y.; He, Q.
Action of bleomycin is affected by bleomycin hydrolase but not by caveolin-1
Int. J. Oncol.
41
2245-2252
2012
Homo sapiens
brenda
Crnovcic, I.; Gan, F.; Yang, D.; Dong, L.B.; Schultz, P.G.; Shen, B.
Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity
Bioorg. Med. Chem. Lett.
28
2670-2674
2018
Homo sapiens (Q13867), Homo sapiens
brenda
Chen, Y.; Zhang, H.; He, Q.
Involvement of bleomycin hydrolase and poly(ADP-ribose) polymerase-1 in Ubc9-mediated resistance to chemotherapy agents
Int. J. Oncol.
50
223-231
2017
Homo sapiens (Q13867), Homo sapiens
brenda