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Disease on EC 3.4.22.36 - caspase-1

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons.
Acid-sensing ion channel 1a mediates acid-induced pyroptosis through calpain-2/calcineurin pathway in rat articular chondrocytes.
The role of Ca2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis.
Acne Vulgaris
Propionibacterium acnes Induces IL-1? Secretion via the NLRP3 Inflammasome in Human Monocytes.
Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne.
Acquired Immunodeficiency Syndrome
Apoptosis and apoptosis-associated perturbations of peripheral blood lymphocytes during HIV infection: comparison between AIDS patients and asymptomatic long-term non-progressors.
Acute Coronary Syndrome
Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation.
Different quantitative apoptotic traits in coronary atherosclerotic plaques from patients with stable angina pectoris and acute coronary syndromes.
The NLRP3 and CASP1 gene polymorphisms are associated with developing of acute coronary syndrome: a case-control study.
Acute Kidney Injury
A Retrospective Cohort Analysis Shows that Coadministration of Minocycline with Colistin in Critically Ill Patients Is Associated with Reduced Frequency of Acute Renal Failure.
Caspase-1 inhibition alleviates acute renal injury in rats with severe acute pancreatitis.
Differential effects of caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney.
Effects of specific interleukin-1beta-converting enzyme inhibitor on ischemic acute renal failure in murine models.
Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice.
Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure.
Neutrophil-independent mechanisms of caspase-1- and IL-18-mediated ischemic acute tubular necrosis in mice.
NLRP3 Inflammasome Knockout Mice Are Protected against Ischemic but Not Cisplatin-Induced Acute Kidney Injury.
Perspective on rhabdomyolysis-induced acute kidney injury and new treatment options.
Reduction of natural killer and natural killer T cells is not protective in cisplatin-induced acute renal failure in mice.
Role of IL-1? in cisplatin-induced acute renal failure in mice.
The impact of Caspase-1 deletion on apoptosis and acute kidney injury in a murine transplant model.
Acute Lung Injury
Critical role for the NLRP3 inflammasome during acute lung injury.
HDAC6 inhibition blocks inflammatory signaling and caspase-1 activation in LPS-induced acute lung injury.
Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1.
Inhibition of Caspase-1 with Tetracycline Ameliorates Acute Lung Injury.
Lycorine ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3 inflammasome activation and pyroptosis.
The NLRP3 Inflammasome is Required for the Development of Hypoxemia in LPS/Mechanical Ventilation Acute Lung Injury.
Therapeutic effects of caspase-1 inhibitors on acute lung injury in experimental severe acute pancreatitis.
[Interventional effects of BAY11-7082 on lung inflammatory response at the early stage and acute lung injury of rats with severe burns].
Acute-On-Chronic Liver Failure
The different expression of caspase-1 in HBV-related liver disease and acts as a biomarker for acute-on-chronic liver failure.
Adenocarcinoma
Interleukin 1 and interleukin 1beta converting enzyme (caspase 1) expression in the human colonic epithelial barrier. Caspase 1 downregulation in colon cancer.
Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis.
[Impact of preoperative drug therapy on the expression of apoptosis markers in colorectal liver metastases].
Adenocarcinoma of Lung
G9A promotes tumor cell growth and invasion by silencing CASP1 in non-small-cell lung cancer cells.
LncRNA MALAT1 promoted high glucose-induced pyroptosis of renal tubular epithelial cell by sponging miR-30c targeting for NLRP3.
Albuminuria
Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia.
Alopecia
Caspase-1 Level Is Higher in the Scalp in Androgenetic Alopecia.
Alveolar Bone Loss
Regulation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated periodontal disease.
Role of inflammasomes in the pathogenesis of periodontal disease and therapeutics.
Targeting NLRP3 Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss.
Alzheimer Disease
A Comparison of Gene Expression Changes in the Blood of Individuals Consuming Diets Supplemented with Olives, Nuts or Long-Chain Omega-3 Fatty Acids.
Caspase-1 genetic variation is not associated with Alzheimer's disease risk.
Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer's disease mouse model.
Cdk5-Dependent Activation of Neuronal Inflammasomes in Parkinson's Disease.
Ceramide phosphoethanolamine synthase SMSr is a target of caspase-6 during apoptotic cell death.
Exploring the ring potential of 2,4-diaminopyrimidine derivatives towards the identification of novel caspase-1 inhibitors in Alzheimer's disease therapy.
Expression and activation of caspase-6 in human fetal and adult tissues.
Genetic variation in caspase-1 as predictor of accelerated progression from mild cognitive impairment to Alzheimer's disease.
Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo.
Increased interleukin-1beta converting enzyme expression and activity in Alzheimer disease.
Modeling caspase-1 inhibition: Implications for catalytic mechanism and drug design.
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Non-invasive in vivo imaging of caspase-1 activation enables rapid and spatiotemporal detection of acute and chronic inflammatory disorders.
Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging.
Publisher Correction: Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging.
Recent insights into the regulatory networks of NLRP3 inflammasome activation.
Soluble interleukin-1 receptor type II, IL-18 and caspase-1 in mild cognitive impairment and severe Alzheimer's disease.
The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain.
The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease.
[Effect of pretreatment of acupuncture on learning-memory ability and related protein of NLRP3 inflammasome in hippocampus in Alzheimer's disease like rats].
Amebiasis
Entamoeba histolytica cysteine proteinases with interleukin-1 beta converting enzyme (ICE) activity cause intestinal inflammation and tissue damage in amoebiasis.
Amnesia, Anterograde
Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1.
Amyotrophic Lateral Sclerosis
Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis.
Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis.
Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration.
Interleukin-1beta converting enzyme/Caspase-1 (ICE/Caspase-1) and soluble APO-1/Fas/CD 95 receptor in amyotrophic lateral sclerosis patients.
The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins.
Upregulation of the pro-apoptotic BH3-only peptide harakiri in spinal neurons of amyotrophic lateral sclerosis patients.
Anaplasmosis
ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection.
Anemia, Sickle Cell
The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase.
Aneurysm
Increased Expression of NLRP3 Inflammasome in Wall of Ruptured and Unruptured Human Cerebral Aneurysms: Preliminary Results.
Aneurysm, Ruptured
Increased Expression of NLRP3 Inflammasome in Wall of Ruptured and Unruptured Human Cerebral Aneurysms: Preliminary Results.
Angina, Stable
Different quantitative apoptotic traits in coronary atherosclerotic plaques from patients with stable angina pectoris and acute coronary syndromes.
Anthrax
A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.
Activation of the Nlrp1b inflammasome by reduction of cytosolic ATP.
Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation.
Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome.
CA-074Me protection against anthrax lethal toxin.
Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.
Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin.
Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment.
NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice.
Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin.
Proteasomes control caspase-1 activation in anthrax lethal toxin-mediated cell killing.
Arteritis
IL-1? is Crucial for Induction of Coronary Artery Inflammation in a Mouse Model of Kawasaki Disease.
Arthritis
Caspase-1 level in synovial fluid is high in patients with spondyloarthropathy but not in patients with gout.
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF.
Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3.
Systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome due to a CASP1 variant causing inflammasome hyperactivation.
Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis.
WNT-Inflammasome Signaling Mediates NOD2-Induced Development of Acute Arthritis in Mice.
Arthritis, Experimental
Effects and mechanisms of potent caspase-1 inhibitor VX765 treatment on collagen-induced arthritis in mice.
Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis.
Interleukin-1 beta converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice.
Arthritis, Gouty
Caspase-1 level in synovial fluid is high in patients with spondyloarthropathy but not in patients with gout.
Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1.
Doliroside A attenuates monosodium urate crystals-induced inflammation by targeting NLRP3 inflammasome.
Engagement of fatty acids with toll-like receptor 2 drives interleukin-1? production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis.
Exploring the Therapeutic Composition and Mechanism of Jiang-Suan-Chu-Bi Recipe on Gouty Arthritis Using an Integrated Approach Based on Chemical Profile, Network Pharmacology and Experimental Support Using Molecular Cell Biology.
MicroRNA-302b negatively regulates IL-1? production in response to MSU crystals by targeting IRAK4 and EphA2.
NLRP3 inflammasome inhibitor cucurbitacin B suppresses gout arthritis in mice.
Rhein, An Anthraquinone Drug, Suppresses the NLRP3 Inflammasome and Macrophage Activation in Urate Crystal-Induced Gouty Inflammation.
Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout.
Arthritis, Juvenile
Systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome due to a CASP1 variant causing inflammasome hyperactivation.
Arthritis, Rheumatoid
Bone marrow- and synovium-derived mesenchymal cells promote Th-17 cells through caspase-1 activation: Contribution to rheumatoid arthritis chronicity.
Caspase-1 is active since the early phase of rheumatoid arthritis.
Caspase-1 level in synovial fluid is high in patients with spondyloarthropathy but not in patients with gout.
Caspase-1 mediated interleukin-18 activation in neutrophils promotes the activity of rheumatoid arthritis in a NLRP3 inflammasome independent manner.
Clinical periodontal status and inflammatory cytokines in primary Sjögren syndrome and rheumatoid arthritis.
Effective treatment of rat adjuvant-induced arthritis by celastrol.
Fas-mediated stimulation induces IL-8 secretion by rheumatoid arthritis synoviocytes independently of CPP32-mediated apoptosis.
Genetic support for the role of the NLRP3 inflammasome in psoriasis susceptibility.
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.
Modeling caspase-1 inhibition: Implications for catalytic mechanism and drug design.
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.
NLRP3 gene polymorphisms and expression in rheumatoid arthritis.
Novel irreversible caspase-1 inhibitor attenuates the maturation of intracellular interleukin-1beta.
Potent anti-inflammatory and antiproliferative effects of gambogic acid in a rat model of antigen-induced arthritis.
Thiol-dependent enzymes and their inhibitors: a review.
Asthma
Blockade of the NLRP3/Caspase-1 Axis Ameliorates Airway Neutrophilic Inflammation in a Toluene Diisocyanate-Induced Murine Asthma Model.
Caspase-1 deficiency reduces eosinophilia and interleukin-33 in an asthma exacerbation model.
Elevated expression of the NLRP3 inflammasome in neutrophilic asthma.
Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.
Glucagon-like peptide 1 receptor (GLP-1R) agonist relieved asthmatic airway inflammation via suppression of NLRP3 inflammasome activation in obese asthma mice model.
New variants in NLRP3 inflammasome genes increase risk for asthma and Blomia tropicalis-induced allergy in a Brazilian population.
NLRP3 regulates macrophage M2 polarization through up-regulation of IL-4 in asthma.
Phosphatidylinositol 3-kinases pathway mediates lung caspase-1 activation and high mobility group box 1 production in a toluene-diisocyanate induced murine asthma model.
Regulatory effect of NLRP3 on airway inflammatory response and pyroptosis in mice with asthma.
Role for NLRP3 Inflammasome-mediated, IL-1?-dependent Responses in Severe, Steroid-resistant Asthma.
Synergistic Costimulatory Effect of Chlamydia pneumoniae with Carbon Nanoparticles on NLRP3 Inflammasome-Mediated Interleukin-1? Secretion in Macrophages.
Tight junction, mucin, and inflammasome-related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice.
Astrocytoma
Caspase-1 mediates Fas-induced apoptosis and is up-regulated by interferon-gamma in human astrocytoma cells.
Ataxia
Protective effect of IL-18 on kainate- and IL-1beta-induced cerebellar ataxia in mice.
Atherosclerosis
Activation of NLRP3 inflammasome assembly is associated with smoking status of patients with coronary artery disease.
Baicalin ameliorates atherosclerosis by inhibiting NLRP3 inflammasome in apolipoprotein E-deficient mice.
Bone marrow-specific caspase-1/11 deficiency inhibits atherosclerosis development in Ldlr(-/-) mice.
Cardiovascular diseases, NLRP3 inflammasome, and western dietary patterns.
Caspase-1 Activation Is Related With HIV-Associated Atherosclerosis in an HIV Transgenic Mouse Model and HIV Patient Cohort.
Caspase-1 Deficiency Decreases Atherosclerosis in Apolipoprotein E-Null Mice.
Caspase-1 recognizes extended cleavage sites in its natural substrates.
Caspase-1: an integral regulator of innate immunity.
Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1? Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis.
Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice.
Defining the pathogenesis of inflammatory and immune diseases through database mining.
Effects of NIX-mediated mitophagy on ox-LDL-induced macrophage pyroptosis in atherosclerosis.
Exercise ameliorates endoplasmic reticulum stress-mediated vascular dysfunction in mesenteric arteries in atherosclerosis.
Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis.
Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age.
Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo.
Mitochondrial DAMPs and altered mitochondrial dynamics in OxLDL burden in atherosclerosis.
Myeloid atg5 deletion impairs n-3 PUFA-mediated atheroprotection.
Overexpression of Caspase-1 in Aorta of Patients with Coronary Atherosclerosis.
Protective Effects of Microrna-22 Against Endothelial Cell Injury by Targeting NLRP3 Through Suppression of the Inflammasome Signaling Pathway in a Rat Model of Coronary Heart Disease.
Role of NLRP3 Inflammasomes in Atherosclerosis.
Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis.
VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis.
Autoimmune Diseases
Caspase-1 inhibitor ameliorates experimental autoimmune myasthenia gravis by innate dendric cell IL-1-IL-17 pathway.
Caspase-1 inhibitor regulates humoral responses in experimental autoimmune myasthenia gravis via IL-6- dependent inhibiton of STAT3.
Caspase-1-Processed Cytokines IL-1{beta} and IL-18 Promote IL-17 Production by {gamma}{delta} and CD4 T Cells That Mediate Autoimmunity.
Gm614 Protects Germinal Center B Cells From Death by Suppressing Caspase-1 Transcription in Lupus-Prone Mice.
Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis.
Bacteremia
Caspase-1 Inflammasome Activity in Patients with Staphylococcus aureus Bacteremia.
Bacterial Infections
A Caspase-1 Biosensor to Monitor the Progression of Inflammation In Vivo.
A role for Nod-like receptors in autophagy induced by Shigella infection.
AIEgen-Peptide Conjugate: Phototheranostics for Phagosome-Entrapped Bacteria.
Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling.
Bacterial recognition pathways that lead to inflammasome activation.
Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.
Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18.
Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity.
Caspases as the Key Effectors of Inflammatory Responses Against Bacterial Infection.
Chemical probing reveals insights into the signaling mechanism of inflammasome activation.
Chlamydial Infection of Monocytes Stimulates IL-1beta Secretion Through Activation of the NLRP3 Inflammasome.
Cutting edge: IL-1? processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1.
Cutting edge: NLRC5-dependent activation of the inflammasome.
Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice.
Gasdermin D-independent release of interleukin-1? by living macrophages in response to mycoplasmal lipoproteins and lipopeptides.
Inhibition of ASC enhances the protective role of salvianolic acid A in traumatic brain injury via inhibition of inflammation and recovery of mitochondrial function.
Innate recognition of intracellular bacteria.
Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Molecular characterization reveals involvement of four caspases in the antibacterial immunity of tongue sole (Cynoglossus semilaevis).
NLR-mediated control of inflammasome assembly in the host response against bacterial pathogens.
Nlrc4/Ipaf/CLAN/CARD12: more than a flagellin sensor.
Pyroptosis - a cell death modality of its kind?
Quantitative Analysis of Caspase-1 Activity in Living Cells Through Dynamic Equilibrium of Chlorophyll-Based Nano-assembly Modulated Photoacoustic Signals.
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis.
The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1? Secretion by Inflammasomes.
Barrett Esophagus
Curcumin promotes apoptosis, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinoma.
Behcet Syndrome
Pro-inflammatory cytokine and caspase-1 responses to pattern recognition receptor activation of neutrophils and dendritic cells in Behcet's disease.
Blister
Sea Hare Hydrolysate-Induced Reduction of Human Non-Small Cell Lung Cancer Cell Growth through Regulation of Macrophage Polarization and Non-Apoptotic Regulated Cell Death Pathways.
Bone Diseases
Critical role for inflammasome-independent IL-1? production in osteomyelitis.
Dietary modulation of the microbiome affects autoinflammatory disease.
Bone Resorption
Relevance of Caspase-1 and Nlrp3 Inflammasome on Inflammatory Bone Resorption in A Murine Model of Periodontitis.
Brain Contusion
[The study on expression of caspase-1 in experimental brain contusion of different severity in rats]
Brain Edema
Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injury.
Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke.
Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats.
MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage.
NEK7 Coordinates Rapid Neuroinflammation After Subarachnoid Hemorrhage in Mice.
Peroxynitrite activates NLRP3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia.
Brain Infarction
IRE1? inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats.
Molecular mechanisms of cerebral ischemia-induced neuronal death.
Brain Injuries
Caspase-1 Inhibition Attenuates Hyperoxia-induced Lung and Brain Injury in Neonatal Mice.
Early changes of NLRP3 inflammasome activation after hypoxic-ischemic brain injury in neonatal rats.
Effects of caspase-1 knockout on chronic neural recording quality and longevity: insight into cellular and molecular mechanisms of the reactive tissue response.
Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury.
Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats.
Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death.
High Ca(2+) Influx During Traumatic Brain Injury Leads to Caspase-1-Dependent Neuroinflammation and Cell Death.
Impairment of DHA synthesis alters the expression of neuronal plasticity markers and the brain inflammatory status in mice.
Interleukin-18 involvement in hypoxic-ischemic brain injury.
Recombinant erythropoietin is neuroprotective in a novel mouse oxidative injury model.
Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice.
Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade.
Targeting NLRP3 Inflammasome in Translational Treatment of Nervous System Diseases: An Update.
[Expression of and relationship between caspase-1 and interleukin-18 mRNA in brain tissue of hypoxic-ischemic neonatal rats]
[Expression of caspase - 1 after hypoxic-ischemic brain damage]
[Pyroptosis and stroke].
[Role of caspase-1 and cytokines activated by caspase-1 in brain injury of the developing rats following recurrent seizures.]
[The study on expression of caspase-1 in experimental brain contusion of different severity in rats]
Brain Injuries, Traumatic
Activation of caspase-1 dependent interleukins in developmental brain trauma.
High Ca(2+) Influx During Traumatic Brain Injury Leads to Caspase-1-Dependent Neuroinflammation and Cell Death.
Increases in Bcl-2 and cleavage of caspase-1 and caspase-3 in human brain after head injury.
Inflammasome proteins as biomarkers of traumatic brain injury.
Inhibition of interleukin-1beta converting enzyme family proteases (caspases) reduces cold injury-induced brain trauma and DNA fragmentation in mice.
Levels of caspase-1 in cerebrospinal fluid of patients with traumatic brain injury: correlation with intracranial pressure and outcome.
Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction.
Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade.
Serum Caspase-1 as an Independent Prognostic Factor in Traumatic Brain Injured Patients.
[The study on expression of caspase-1 in experimental brain contusion of different severity in rats]
Brain Ischemia
A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat.
Caspase-1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia.
Early NFkappaB activation is inhibited during focal cerebral ischemia in interleukin-1beta-converting enzyme deficient mice.
Expression of tumor necrosis factor-alpha and intercellular adhesion molecule-1 after focal cerebral ischemia in interleukin-1beta converting enzyme deficient mice.
Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia.
Interleukin-18 expression after focal ischemia of the rat brain: association with the late-stage inflammatory response.
Intranasal Delivery of a Caspase-1 Inhibitor in the Treatment of Global Cerebral Ischemia.
Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice.
Total saponins of Panax notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion.
[Effect of active fraction of buyang huanwu decoction on caspase expression in rats after focal cerebral ischemic reperfusion]
[Effects of Panax notoginseng saponins on mRNA expressions of interleukin-1 beta, its correlative factors and cysteinyl-aspartate specific protease after cerebral ischemia-reperfusion in rats]
[Neuronal death mechanisms in cerebral ischemia]
Brain Neoplasms
HER2 Heterogeneity Is Associated with Poor Survival in HER2-Positive Breast Cancer.
Breast Neoplasms
A molecular mechanism for stress-induced alterations in susceptibility to disease.
Caspase-1 cleaves PPAR? for potentiating the pro-tumor action of TAMs.
Detection of proteins associated with the pyroptosis signaling pathway in breast cancer tissues and their significance.
Expression of Caspase-1 in breast cancer tissues and its effects on cell proliferation, apoptosis and invasion.
Globular Adiponectin Inhibits Breast Cancer Cell Growth through Modulation of Inflammasome Activation: Critical Role of Sestrin2 and AMPK Signaling.
Growth of breast cancer cells by leptin is mediated via activation of the inflammasome: Critical roles of estrogen receptor signaling and reactive oxygen species production.
HER2 Heterogeneity Is Associated with Poor Survival in HER2-Positive Breast Cancer.
Implications of caspase-dependent proteolytic cleavage of cyclin A1 in DNA damage-induced cell death.
Macrophage-mediated clearance of cells undergoing caspase-3-independent death.
Methylation of ASC/TMS1, a proapoptotic gene responsible for activating procaspase-1, in human colorectal cancer.
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
NLRC4, ASC and Caspase-1 Are Inflammasome Components that Are Mediated by P2Y2R Activation in Breast Cancer Cells.
Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells.
Bronchiolitis
Lymphocyte apoptosis in acute respiratory syncytial virus bronchiolitis.
Brucellosis
Caspases-1 and caspase-11 mediate pyroptosis, inflammation, and control of Brucella joint infection.
The relationship between caspase-1 related inflammasome expression and serum inflammatory cytokine levels during acute brucellosis.
Burkitt Lymphoma
Apoptosis in B-cell lymphomas and reactive lymphoid tissues always involves activation of caspase 3 as determined by a new in situ detection method.
Candidiasis
In this issue.
Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice.
The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis.
Carcinogenesis
Activation of TGF-beta signalling in human prostate cancer cells suppresses tumorigenicity via deregulation of cell cycle progression and induction of caspase-1 mediated apoptosis: significance in prostate tumorigenesis.
ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice.
Caspase-1 from Human Myeloid-Derived Suppressor Cells Can Promote T Cell-Independent Tumor Proliferation.
Caspase-11 attenuates gastrointestinal inflammation and experimental colitis pathogenesis.
Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation.
Differential roles of caspase-1 and caspase-11 in infection and inflammation.
Emerging Roles for Interleukin-18 in the Gastrointestinal Tumor Microenvironment.
Exploration of DNA Methylation-Driven Genes in Papillary Thyroid Carcinoma Based on the Cancer Genome Atlas.
Gene expression profiling of biological pathway alterations by radiation exposure.
Inflammasome, inflammation and cancer: an interrelated pathobiological triad.
Inflammasome-mediated suppression of inflammation-induced colorectal cancer progression is mediated by direct regulation of epithelial cell proliferation.
Inflammasomes in cancer: Effect of epigenetic and autophagic modulations.
Inflammasomes in carcinogenesis and anticancer immune responses.
Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.
Loss of caspase-1 and caspase-3 protein expression in human prostate cancer.
Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis.
Silencing of the caspase-1 gene occurs in murine and human renal cancer cells and causes solid tumor growth in vivo.
The constitutive protease release by primary human acute myeloid leukemia cells.
The NLRP3 inflammasome: a therapeutic target for inflammation-associated cancers.
Carcinoma
A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.
All-trans-retinoic acid activates caspase-1 in a dose-dependent manner in cervical squamous carcinoma cells.
Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.
Caspase-1 from Human Myeloid-Derived Suppressor Cells Can Promote T Cell-Independent Tumor Proliferation.
Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis.
Caspase-1alpha is down-regulated in human ovarian cancer cells and the overexpression of caspase-1alpha induces apoptosis.
Coordinate regulation of IFN consensus sequence-binding protein and caspase-1 in the sensitization of human colon carcinoma cells to Fas-mediated apoptosis by IFN-gamma.
Detection of apoptosis and expression of apoptosis-associated proteins as early predictors of prognosis after irradiation therapy in stage IIIb uterine cervical cancer.
Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma.
Expression of Inflammasome-Associated Proteins in Human Oropharyngeal Squamous Cell Carcinoma.
In vitro evidence of NLRP3 inflammasome regulation by histone demethylase LSD2 in renal cancer: a pilot study.
Inhibition of caspase-1 induces cell death in pancreatic carcinoma cells and potentially modulates expression levels of bcl-2 family proteins.
Inhibition of epidermal growth factor-induced interleukin-1beta-converting enzyme expression reduces proliferation in the pancreatic carcinoma cell line AsPC-1.
Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death.
Interferon gamma inhibits growth of human pancreatic carcinoma cells via caspase-1 dependent induction of apoptosis.
Interferon-gamma induces regression of epithelial cell carcinoma: critical roles of IRF-1 and ICSBP transcription factors.
Involvement of caspases in 5-FU induced apoptosis in an oral cancer cell line.
Loss of caspase-1 gene expression in human gastric carcinomas and cell lines.
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Myeloid tumor necrosis factor and heme oxygenase-1 regulate the progression of colorectal liver metastases during hepatic ischemia-reperfusion.
Over-expression of c-FLIP confers the resistance to TRAIL-induced apoptosis on gallbladder carcinoma.
Overexpression of caspase-1 (interleukin-1beta converting enzyme) in chronic pancreatitis and its participation in apoptosis and proliferation.
RalB degradation by dihydroartemisinin induces autophagy and IFI16/caspase-1 inflammasome depression in the human laryngeal squamous cell carcinoma.
Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95.
Suppression of intracellular resistance factors by adriamycin augments heat-induced apoptosis via interleukin-1beta-converting enzyme activation in pancreatic carcinoma cells.
The expression of FHIT, PCNA and EGFR in benign and malignant breast lesions.
The study of the calpain and caspase-1 expression in ultrastructural dynamics of Ehrlich ascites carcinoma necrosis.
Thiol-mediated apoptosis in prostate carcinoma cells.
Carcinoma, Adenosquamous
Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation.
Carcinoma, Hepatocellular
High mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases.
Human hepatocellular carcinoma cells resist to TRAIL-induced apoptosis, and the resistance is abolished by cisplatin.
Sorafenib inhibits caspase-1 expression through suppressing TLR4/stat3/SUMO1 pathway in hepatocellular carcinoma.
The novel interplay between CD44 standard isoform and the caspase-1/IL1B pathway to induce hepatocellular carcinoma progression.
Carcinoma, Intraductal, Noninfiltrating
The expression of FHIT, PCNA and EGFR in benign and malignant breast lesions.
Carcinoma, Non-Small-Cell Lung
Differentially expressed apoptotic genes in early stage lung adenocarcinoma predicted by expression profiling.
Carcinoma, Renal Cell
In vitro evidence of NLRP3 inflammasome regulation by histone demethylase LSD2 in renal cancer: a pilot study.
Silencing of the caspase-1 gene occurs in murine and human renal cancer cells and causes solid tumor growth in vivo.
Carcinoma, Squamous Cell
All-trans-retinoic acid activates caspase-1 in a dose-dependent manner in cervical squamous carcinoma cells.
Caspase-1 from Human Myeloid-Derived Suppressor Cells Can Promote T Cell-Independent Tumor Proliferation.
Detection of apoptosis and expression of apoptosis-associated proteins as early predictors of prognosis after irradiation therapy in stage IIIb uterine cervical cancer.
Involvement of caspases in 5-FU induced apoptosis in an oral cancer cell line.
P2X7 receptor and NLRP3 inflammasome activation in head and neck cancer.
Cardio-Renal Syndrome
Caspase-1 as Molecular Key in Cardiac Remodeling during Cardiorenal Syndrome Type 3 in the Murine Model.
Cardiomegaly
Caspase-1 Abrogates the Salutary Effects of Hypertrophic Preconditioning in Pressure Overload Hearts via IL-1? and IL-18.
Caspase-1 as Molecular Key in Cardiac Remodeling during Cardiorenal Syndrome Type 3 in the Murine Model.
Caspase-1 regulate AngII-induced cardiomyocyte hypertrophy via upregulation of IL-1?.
NLRP3-mediated pyroptosis aggravates pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction in mice: cardioprotective role of irisin.
Cardiomyopathies
Association of caspase-1 polymorphisms with Chagas cardiomyopathy among individuals in Santa Cruz, Bolivia.
Cardiomyopathy, Dilated
Altered interleukin-1 receptor antagonist and interleukin-18 mRNA expression in myocardial tissues of patients with dilatated cardiomyopathy.
Cardiotoxicity
Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death with the apoptotic component blunted by both caspase-2 and caspase-3 inhibitors.
Cardiovascular Diseases
Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1?-, IL-18- and sirtuin-1-independent pathways.
Caspase inhibitors: a review of recently patented compounds (2013-2015).
Caspases and inflammasomes in metabolic inflammation.
Multifactorial Activation of NLRP3 Inflammasome: Relevance for a Precision Approach to Atherosclerotic Cardiovascular Risk and Disease.
Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study.
Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases.
caspase-1 deficiency
Amyloid-? induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer's disease.
Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to ?-Amyloid peptide accumulation.
Bone marrow-specific caspase-1/11 deficiency inhibits atherosclerosis development in Ldlr(-/-) mice.
Caspase 1 deficiency reduces inflammation-induced brain transcription.
Caspase-1 Deficiency Alleviates Dopaminergic Neuronal Death via Inhibiting Caspase-7/AIF Pathway in MPTP/p Mouse Model of Parkinson's Disease.
Caspase-1 Deficiency Decreases Atherosclerosis in Apolipoprotein E-Null Mice.
Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion.
Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity.
Caspase-1 deficiency reduces eosinophilia and interleukin-33 in an asthma exacerbation model.
Caspase-1 independent viral clearance and adaptive immunity against mucosal respiratory syncytial virus infection.
Caspase-1 is not involved in experimental hepatitis in mouse.
Caspase-1 is not required for type 1 diabetes in the NOD mouse.
Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy.
Caspases as drug targets in ischemic organ injury.
Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice.
Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition.
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice.
Interleukin-22 Attenuated Renal Tubular Injury in Aristolochic Acid Nephropathy via Suppressing Activation of NLRP3 Inflammasome.
Lipoxin A4 suppresses angiotensin II type 1 receptor autoantibody in preeclampsia via modulating caspase-1.
NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model.
NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation.
Obesity development in caspase-1-deficient mice.
The caspase 1 inflammasome is not required for control of murine Lyme borreliosis.
caspase-11 deficiency
Caspase-11 Contributes to Oviduct Pathology during Genital Chlamydia Infection in Mice.
caspase-12 deficiency
Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice.
caspase-3 deficiency
Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy.
caspase-9 deficiency
Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development.
Cataract
Down-regulation of CRTAC1 attenuates UVB-induced pyroptosis in HLECs through inhibiting ROS production.
Inhibition of lens epithelial cells by Fas-specific antibody activating Fas-Fas ligand system.
Long Non-Coding RNA KCNQ1OT1 Promotes Cataractogenesis via miR-214 and Activation of the Caspase-1 Pathway.
Role of short-wavelength blue light in the formation of cataracts and the expression of caspase-1, caspase-11, Gasdermin D in rat lens epithelial cells: insights into a novel pathogenic mmechanism of cataracts.
Cerebral Hemorrhage
Ac-YVAD-CMK Decreases Blood-Brain Barrier Degradation by Inhibiting Caspase-1 Activation of Interleukin-1beta in Intracerebral Hemorrhage Mouse Model.
Pretreatment with low-dose fimasartan ameliorates NLRP3 inflammasome-mediated neuroinflammation and brain injury after intracerebral hemorrhage.
Cerebral Infarction
Baicalin Inhibits NLRP3 Inflammasome Activity Via the AMPK Signaling Pathway to Alleviate Cerebral Ischemia-Reperfusion Injury.
Hypoxic preconditioning reduces NLRP3 inflammasome expression and protects against cerebral ischemia/reperfusion injury.
Inhibition of Caspase-1 Ameliorates Ischemia-Associated Blood-Brain Barrier Dysfunction and Integrity by Suppressing Pyroptosis Activation.
Targeting NLRP3 Inflammasome in Translational Treatment of Nervous System Diseases: An Update.
[Astragaloside IV attenuates cerebral ischemia and reperfusion injury and reduces activation of NLRP3 inflammasome and NF-?B phosphorylation in rats following a transient middle cerebral artery occlusion].
[Protective effect and immune mechanism of berberine on cerebral ischemia/reperfusion injury in rats].
Chagas Cardiomyopathy
Association of caspase-1 polymorphisms with Chagas cardiomyopathy among individuals in Santa Cruz, Bolivia.
Genetic association study of NLRP1, CARD, and CASP1 inflammasome genes with chronic Chagas cardiomyopathy among Trypanosoma cruzi seropositive patients in Bolivia.
Chickenpox
Varicella-Zoster virus infection triggers formation of an IL-1{beta} processing inflammasome complex.
Chlamydia Infections
Caspase-11 Contributes to Oviduct Pathology during Genital Chlamydia Infection in Mice.
Cholangitis
Galectin-3 regulates inflammasome activation in cholestatic liver injury.
Cholera
Recombinant fusion protein of cholera toxin B subunit with YVAD secreted by Lactobacillus casei inhibits lipopolysaccharide-induced caspase-1 activation and subsequent IL-1 beta secretion in Caco-2 cells.
Cholestasis
Regulation of epithelial injury and bile duct obstruction by NLRP3, IL-1R1 in experimental biliary atresia.
Cholesteatoma
Activation of NLRP3 inflammasome in human middle ear cholesteatoma and chronic otitis media.
Chorioamnionitis
A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis.
A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis.
Coinfection
Susceptibility to M tuberculosis infection in HIV-positive patients is associated with CARD8 genetic variant.
Colitis
1'-Acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression.
A Caspase-1 Biosensor to Monitor the Progression of Inflammation In Vivo.
A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation.
Altered expression of inflammasomes in Hirschsprung's disease.
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
Chlorogenic Acid Suppresses miR-155 and Ameliorates Ulcerative Colitis through the NF-?B/NLRP3 Inflammasome Pathway.
Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial Pyroptosis by Activating the NF-?B Signaling Pathway.
Comparison of experimental mouse models of inflammatory bowel disease.
Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice.
Extracellular ATP mediates inflammatory responses in colitis via P2?×?7 receptor signaling.
Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome.
Inflammasome activation has an important role in the development of spontaneous colitis.
Libertellenone M, a diterpene derived from an endophytic fungus Phomopsis sp. S12, protects against DSS-induced colitis via inhibiting both nuclear translocation of NF-?B and NLRP3 inflammasome activation.
Magnesium lithospermate B acts against dextran sodiumsulfate-induced ulcerative colitis by inhibiting activation of the NRLP3/ASC/Caspase-1 pathway.
Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation.
The aqueous extract of Phellinus igniarius (SH) ameliorates dextran sodium sulfate-induced colitis in C57BL/6 mice.
The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression.
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.
Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis.
Transcriptional profiling identifies caspase-1 as a T cell-intrinsic regulator of Th17 differentiation.
Colitis, Ulcerative
Emerging views of mitophagy in immunity and autoimmune diseases.
Expression profiling of apoptosis-related genes in enterocytes isolated from patients with ulcerative colitis.
Colitis-Associated Neoplasms
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Colonic Neoplasms
Altered mechanisms of apoptosis in colon cancer: Fas resistance and counterattack in the tumor-immune conflict.
Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP.
Interleukin 1 and interleukin 1beta converting enzyme (caspase 1) expression in the human colonic epithelial barrier. Caspase 1 downregulation in colon cancer.
Intracellular signaling dynamics during apoptosis execution in the presence or absence of X-linked-inhibitor-of-apoptosis-protein.
Liver X receptor ? activation induces pyroptosis of human and murine colon cancer cells.
Prognostic impact of {triangleup}TAp73 isoform levels and their target genes in colon cancer patients.
Colorectal Neoplasms
Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential.
Frameshift mutation at a mononucleotide repeat in CASP1 is rare in gastric and colorectal carcinomas with microsatellite instability.
GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells.
Methylation of ASC/TMS1, a proapoptotic gene responsible for activating procaspase-1, in human colorectal cancer.
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Pyroptosis is involved in the inhibitory effect of FL118 on growth and metastasis in colorectal cancer.
Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes.
Coma
Serum Caspase-1 as an Independent Prognostic Factor in Traumatic Brain Injured Patients.
Common Cold
Thiol-dependent enzymes and their inhibitors: a review.
Communicable Diseases
Cdk5-Dependent Activation of Neuronal Inflammasomes in Parkinson's Disease.
Mechanistic Insight Into the Activation of the NLRP3 Inflammasome by Neisseria gonorrhoeae in Macrophages.
The inflammatory caspases: guardians against infections and sepsis.
[Pyroptosis and stroke].
[TLR-4 involvement in pyroptosis of mice with pulmonary inflammation infected by Actinobacillus pleuropneumoniae].
Connective Tissue Diseases
Increased expression of caspase 1 during active phase of connective tissue disease.
Coronary Artery Disease
Effects of exercise training on inflammasome-related mediators and their associations to glucometabolic variables in patients with combined coronary artery disease and type 2 diabetes mellitus: Sub-study of a randomized control trial.
Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk.
Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study.
Overexpression of Caspase-1 in Aorta of Patients with Coronary Atherosclerosis.
Uremic toxins are conditional danger- or homeostasis-associated molecular patterns.
COVID-19
Caspases and therapeutic potential of caspase inhibitors in moderate-severe SARS CoV2 infection and long COVID.
Diseasome and comorbidities complexities of SARS-CoV-2 infection with common malignant diseases.
Endothelial Dysfunction and Thrombosis in Patients With COVID-19-Brief Report.
Heterogeneous NLRP3 inflammasome signature in circulating myeloid cells as a biomarker of COVID-19 severity.
Innate immune response analysis in COVID-19 and kawasaki disease reveals MIS-C predictors.
SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage.
The Inflammasome in Times of COVID-19.
Cowpox
Activation of caspases in pig kidney cells infected with wild-type and CrmA/SPI-2 mutants of cowpox and rabbitpox viruses.
Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.
Cisplatin-induced apoptosis of immortalized mouse proximal tubule cells is mediated by interleukin-1 beta converting enzyme (ICE) family of proteases but inhibited by overexpression of Bcl-2.
Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance.
Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity.
Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.
Myxoma virus Serp2 is a weak inhibitor of granzyme B and interleukin-1beta-converting enzyme in vitro and unlike CrmA cannot block apoptosis in cowpox virus-infected cells.
Subcellular localization of CrmA: identification of a novel leucine-rich nuclear export signal conserved in anti-apoptotic serpins.
Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.
Craniocerebral Trauma
Increases in Bcl-2 and cleavage of caspase-1 and caspase-3 in human brain after head injury.
Ritonavir and disulfiram have potential to inhibit caspase-1 mediated inflammation and reduce neurological sequelae after minor blast exposure.
Crohn Disease
Analysis of interleukin-18, interleukin-1 converting enzyme (ICE) and interleukin-18-related cytokines in Crohn's disease lesions.
Emerging views of mitophagy in immunity and autoimmune diseases.
Genetic support for the role of the NLRP3 inflammasome in psoriasis susceptibility.
Herb-partitioned moxibustion alleviates colonic inflammation in Crohn's disease rats by inhibiting hyperactivation of the NLRP3 inflammasome via regulation of the P2X7R-Pannexin-1 signaling pathway.
Heterogeneity of subordination of the IL-18/IFN-? axis to caspase-1 among patients with Crohn's disease.
The autoinflammatory syndromes.
Cryopyrin-Associated Periodic Syndromes
?-Glucan-induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies.
A80: Skeletal Features of Neonatal-Onset Multisystem Inflammatory Disease (NOMID) on Anakinra Treatment: Long-Term Follow-up.
Cryopyrin-associated periodic syndromes: background and therapeutics.
Enhanced interleukin-1beta and interleukin-18 release in a patient with chronic infantile neurologic, cutaneous, articular syndrome.
HSC70 regulates cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4.
In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes.
Muckle-Wells Syndrome and Male Hypofertility: A Case Series.
Novel Majeed Syndrome-Causing LPIN2 Mutations Link Bone Inflammation to Inflammatory M2 Macrophages and Accelerated Osteoclastogenesis.
Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors.
The ketone metabolite ?-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.
The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing.
[Cryopyrin-associated periodic syndromes].
Cystadenocarcinoma, Serous
Cardamonin inhibits cell proliferation by caspase-mediated cleavage of Raptor.
Cystinosis
Inflammasome Activation by Cystine Crystals: Implications for the Pathogenesis of Cystinosis.
Dementia
Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease.
Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease.
Demyelinating Diseases
A nitric oxide releasing derivative of flurbiprofen inhibits experimental autoimmune encephalomyelitis.
Caspase-1 regulates the inflammatory process leading to autoimmune demyelination.
Ellagic acid ameliorates neuroinflammation and demyelination in experimental autoimmune encephalomyelitis: Involvement of NLRP3 and pyroptosis.
Intranasal anti-caspase-1 therapy preserves myelin and glucose metabolism in a model of progressive multiple sclerosis.
Sinomenine Alleviates Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis through Inhibiting NLRP3 Inflammasome.
Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+FoxP3+ Treg cell population and prevents signs of experimental autoimmune encephalomyelitis in mice.
The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18.
Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis.
Dengue
CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages.
Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome.
Dengue virus-infected human monocytes trigger late activation of caspase-1, which mediates pro-inflammatory IL-1? secretion and pyroptosis.
Gene expression profiling by microarray analysis reveals an important role for caspase-1 in dengue virus-induced p53-mediated apoptosis.
Inflammatory status and severity of disease in dengue patients are associated with lipoprotein alterations.
Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation.
Dermatitis
Anticancer agent ABT-737 possesses anti-atopic dermatitis activity via blockade of caspase-1 in atopic dermatitis in vitro and in vivo models.
Persistent secretion of IL-18 in the skin contributes to IgE response in mice.
Systemic Dermatitis Model Mice Exhibit Atrophy of Visceral Adipose Tissue and Increase Stromal Cells via Skin-Derived Inflammatory Cytokines.
The Inflammasome, an Innate Immunity Guardian, Participates in Skin Urticarial Reactions and Contact Hypersensitivity.
Topical suplatast tosilate (IPD) ameliorates Th2 cytokine-mediated dermatitis in caspase-1 transgenic mice by downregulating interleukin-4 and interleukin-5.
Dermatitis, Atopic
Anticancer agent ABT-737 possesses anti-atopic dermatitis activity via blockade of caspase-1 in atopic dermatitis in vitro and in vivo models.
Dermatitis, Contact
Caspase inhibitors: a review of recently patented compounds (2013-2015).
Induction of biologically active IL-1 beta-converting enzyme and mature IL-1 beta in human keratinocytes by inflammatory and immunologic stimuli.
The Inflammasome, an Innate Immunity Guardian, Participates in Skin Urticarial Reactions and Contact Hypersensitivity.
Diabetes Complications
Caspase-1 regulate AngII-induced cardiomyocyte hypertrophy via upregulation of IL-1?.
High glucose inhibits proliferation and differentiation of osteoblast in alveolar bone by inducing pyroptosis.
Diabetes Mellitus
Effects of exercise training on inflammasome-related mediators and their associations to glucometabolic variables in patients with combined coronary artery disease and type 2 diabetes mellitus: Sub-study of a randomized control trial.
Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin.
Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-?1/Smads signaling in diabetic cardiomyopathy.
Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases.
[Intensity of apoptotic processes, aconitate hydratase activity and citrate level in patients with type 2 diabetes mellitus complicated steatohepatitis under application of epifamin at basic therapy].
Diabetes Mellitus, Type 1
Caspase-1 is not required for type 1 diabetes in the NOD mouse.
Mitochondrial DNA Promotes NLRP3 Inflammasome Activation and Contributes to Endothelial Dysfunction and Inflammation in Type 1 Diabetes.
Diabetes Mellitus, Type 2
Caspase-1: an integral regulator of innate immunity.
Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes.
Effects of exercise training on inflammasome-related mediators and their associations to glucometabolic variables in patients with combined coronary artery disease and type 2 diabetes mellitus: Sub-study of a randomized control trial.
Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo.
Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin.
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.
Study on caspase-1 and partial cognitive impairment in the comorbidity of type 2 diabetes and MDD.
Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart.
When Beauty Is Skin Deep: Regulation of the Wound Response by Caspase-8, RIPK3, and the Inflammasome.
[Intensity of apoptotic processes, aconitate hydratase activity and citrate level in patients with type 2 diabetes mellitus complicated steatohepatitis under application of epifamin at basic therapy].
Diabetic Cardiomyopathies
Cardioprotective and anti-inflammatory effects of interleukin converting enzyme inhibition in experimental diabetic cardiomyopathy.
Diabetic Nephropathies
Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy.
Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy.
Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation.
VX-765 ameliorates inflammation and extracellular matrix accumulation by inhibiting the NOX1/ROS/NF-?B pathway in diabetic nephropathy.
Diabetic Retinopathy
Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342-3p targeting of CASP1 in diabetic retinopathy.
NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy.
Potential new strategies to prevent the development of diabetic retinopathy.
Dry Eye Syndromes
Reactive oxygen species activated NLRP3 inflammasomes prime environment-induced murine dry eye.
Upregulation of NLRP3 Inflammasome in the Tears and Ocular Surface of Dry Eye Patients.
Dysentery, Bacillary
A novel caspase-1/toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages.
A role for Nod-like receptors in autophagy induced by Shigella infection.
Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2.
Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation.
Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages.
Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkc?.
Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB.
The Shigella Type III Secretion Effector IpaH4.5 Targets NLRP3 to Activate Inflammasome Signaling.
Dyskinesias
Caspase-1 Deficiency Alleviates Dopaminergic Neuronal Death via Inhibiting Caspase-7/AIF Pathway in MPTP/p Mouse Model of Parkinson's Disease.
Dyslipidemias
Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats.
Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation.
Dyspnea
Caspase-1 inhibitor reduced the lung injury in a mouse model of pleuropneumonia caused by Actinobacillus pleuropneumoniae.
Dystonia
[Effect of a complex treatment, including glutargin and erbisol on the blood plasma content of protein P53, apoptotic markers of type II, activity of caspases and the level of sCD 117 in patients with autonomic-vascular dystonia]
Ehrlichiosis
Type I interferon contributes to noncanonical inflammasome activation, mediates immunopathology, and impairs protective immunity during fatal infection with lipopolysaccharide-negative ehrlichiae.
Encephalitis
Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair.
Expression of inducible nitric oxide synthase, interleukin-1 and caspase-1 in HIV-1 encephalitis.
The Fas Ligand/Fas Death Receptor Pathways Contribute to Propofol-Induced Apoptosis and Neuroinflammation in the Brain of Neonatal Rats.
The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release.
TNF-? May Mediate Inflammasome Activation in the Absence of Bacterial Infection in More than One Way.
Encephalitis, Japanese
CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages.
Encephalomyelitis
AIM2 in regulatory T cells restrains autoimmune diseases.
Caspase-1 regulates the inflammatory process leading to autoimmune demyelination.
Cutting Edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis.
Differential induction of interleukin-12, interleukin-18, and interleukin-1beta converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat.
Prostaglandin E2 produced following infection with Theiler's virus promotes the pathogenesis of demyelinating disease.
Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review.
Encephalomyelitis, Autoimmune, Experimental
A role for caspase-1 and -3 in the pathology of experimental allergic encephalomyelitis : inflammation versus degeneration.
AIM2 in regulatory T cells restrains autoimmune diseases.
Caspase-1 regulates the inflammatory process leading to autoimmune demyelination.
Cutting Edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis.
Differential induction of interleukin-12, interleukin-18, and interleukin-1beta converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat.
Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review.
Endometrial Neoplasms
Expression of cellular FLICE/caspase-8 inhibitory protein is associated with malignant potential in endometrial carcinoma.
Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway.
NLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer.
Endometriosis
Imbalance in cytokines from interleukin-1 family - role in pathogenesis of endometriosis.
Quantitative expression of apoptosis-regulating genes in endometrium from women with and without endometriosis.
Endotoxemia
Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases.
Deletion of Src family kinase Lyn aggravates endotoxin-induced lung inflammation.
Differential roles of caspase-1 and caspase-11 in infection and inflammation.
Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia.
Inhibition of caspase-1 activation in gram-negative sepsis and experimental endotoxemia.
Interleukin-18 and host defense against infection.
Parsing the IL-37-Mediated Suppression of Inflammasome Function.
Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemia.
Enterovirus Infections
Pyroptosis induced by enterovirus 71 and coxsackievirus B3 infection affects viral replication and host response.
Eosinophilia
Caspase-1 deficiency reduces eosinophilia and interleukin-33 in an asthma exacerbation model.
Eosinophilic Granuloma
Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma J. infection.
Epilepsies, Partial
Peripheral blood expression levels of inflammasome complex components in two different focal epilepsy syndromes.
Epilepsy
Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1? and IL-6 Pathways.
Interleukin-1? Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice.
NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model.
NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL-? in sclerotic hippocampi.
Peripheral blood expression levels of inflammasome complex components in two different focal epilepsy syndromes.
Subicular Caspase-1 Contributes to Pharmacoresistance in Temporal Lobe Epilepsy.
VX-765 ameliorates renal injury and fibrosis in diabetes by regulating caspase-1-mediated pyroptosis and inflammation.
Epilepsy, Temporal Lobe
NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model.
NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL-? in sclerotic hippocampi.
Peripheral blood expression levels of inflammasome complex components in two different focal epilepsy syndromes.
Subicular Caspase-1 Contributes to Pharmacoresistance in Temporal Lobe Epilepsy.
Erythema
Intradermal transfer of caspase-1 (CASP1) DNA into mouse dissects: role of CASP1 in interleukin-1beta associated skin inflammation and apoptotic cell death.
Escherichia coli Infections
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.
Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemia.
Esophageal Diseases
Characterizing caspase-1 involvement during esophageal disease progression.
Esophagitis
Alcohol accumulation promotes esophagitis via pyroptosis activation.
Exanthema
The Inflammasome, an Innate Immunity Guardian, Participates in Skin Urticarial Reactions and Contact Hypersensitivity.
Eye Infections
Differential ASC requirements reveal a key role for neutrophils and a noncanonical IL-1? response to Pseudomonas aeruginosa.
Familial Mediterranean Fever
A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation.
Dysregulated production of interleukin-1? upon activation of the NLRP3 inflammasome in patients with familial Mediterranean fever.
Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis.
IL-1? and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1? or Caspase-8 in a Mouse Model of Familial Mediterranean Fever.
Pyrin Activates the ASC Pyroptosome in Response to Engagement by Autoinflammatory PSTPIP1 Mutants.
Ribotoxic stress through p38 mitogen-activated protein kinase activates in vitro the human pyrin inflammasome.
The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.
The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment.
Fatty Liver
Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis.
Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis.
Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation.
Expression of NALPs in adipose and the fibrotic progression of non-alcoholic fatty liver disease in obese subjects.
Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells.
High-Fat Diet-Induced IL-17A Exacerbates Psoriasiform Dermatitis in a Mouse Model of Steatohepatitis.
Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice.
Inhibition of hepatic interleukin-18 production by rosiglitazone in a rat model of nonalcoholic fatty liver disease.
Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR-/-.Leiden mice.
Mice Deficient in the IL-1? Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.
Mitochondrial membrane protein mitofusin 2 as a potential therapeutic target for treating free fatty acid-induced hepatic inflammation in dairy cows during early lactation.
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.
[Intensity of apoptotic processes, aconitate hydratase activity and citrate level in patients with type 2 diabetes mellitus complicated steatohepatitis under application of epifamin at basic therapy].
Gallbladder Neoplasms
miR-125b suppresses cellular proliferation by targeting c-FLIP in gallbladder carcinoma.
Gastritis
A New Participant in the Pathogenesis of Alcoholic Gastritis: Pyroptosis.
Caspase-1 Has Both Pro-Inflammatory and Regulatory Properties in Helicobacter Infections, Which Are Differentially Mediated by Its Substrates IL-1? and IL-18.
Gastrointestinal Stromal Tumors
Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors.
Gingivitis
Effects of bodybuilding and protein supplements in saliva, gingival crevicular fluid, and serum.
Glaucoma
NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma.
Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model.
Glioblastoma
Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma.
Cell death in amyotrophic lateral sclerosis: interplay between neuronal and glial cells.
Glioma
A microarray study to characterize the molecular mechanism of TIMP-3-mediated tumor rejection.
Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1? and IL-18 Release.
Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells.
Delivery of Therapeutic Proteins via Extracellular Vesicles: Review and Potential Treatments for Parkinson's Disease, Glioma, and Schwannoma.
miRNA-214 Inhibits Cellular Proliferation and Migration in Glioma Cells Targeting Caspase 1 Involved in Pyroptosis.
Retroviral delivery and tetracycline-dependent expression of IL-1beta-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells.
Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma.
Wild-type p53-dependent etoposide-induced apoptosis mediated by caspase-3 activation in human glioma cells.
Glomerulonephritis
AIM2 Mediates Inflammation-Associated Renal Damage in Hepatitis B Virus-Associated Glomerulonephritis by Regulating Caspase-1, IL-1 ? , and IL-18.
Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1.
The Small Tellurium Compound AS101 Ameliorates Rat Crescentic Glomerulonephritis: Association with Inhibition of Macrophage Caspase-1 Activity via Very Late Antigen-4 Inactivation.
Gout
Alpha2B-Adrenergic Receptor Regulates Neutrophil Recruitment in MSU-Induced Peritoneal Inflammation.
Caspase-1 level in synovial fluid is high in patients with spondyloarthropathy but not in patients with gout.
Caspase-1: an integral regulator of innate immunity.
Cytokine Profile in Gout: Inflammation Driven by IL-6 and IL-18?
Enhanced p62 expression through impaired proteasomal degradation is involved in caspase-1 activation in monosodium urate crystal-induced interleukin-1? expression.
EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages.
Expression of Caspase-1 Gene Transcript Variant mRNA in Peripheral Blood Mononuclear Cells of Patients with Primary Gout in Different TCM Syndromes.
Genetic variants of PPAR-gamma coactivator 1B augment NLRP3-mediated inflammation in gouty arthritis.
High-mobility group box 1 is responsible for monosodium urate crystal-induced inflammation in human U937 macrophages.
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.
Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1?
Phosphoinositide-3 kinase gamma regulates caspase-1 activation and leukocyte recruitment in acute murine gout.
Recent insights into the regulatory networks of NLRP3 inflammasome activation.
Soluble uric acid increases NALP3 inflammasome and interleukin-1? expression in human primary renal proximal tubule epithelial cells through the Toll-like receptor 4-mediated pathway.
Graft vs Host Disease
A Caspase-1 Biosensor to Monitor the Progression of Inflammation In Vivo.
Caspase-1 inhibition ameliorates murine acute graft versus host disease by modulating the Th1/Th17/Treg balance.
Molecular and computational diagnostic approach identifies FOXP3, ICOS, CD52 and CASP1 as the most informative biomarkers in acute graft versus host disease.
[Caspase1 Inhibitor Ac-YVAD-CMK Prevents and Treats the Acute Graft Versus Host Disease in Mice].
Granuloma
Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice.
Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1.
PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques.
The NLRP3 inflammasome pathway is activated in sarcoidosis and involved in granuloma formation.
Granulomatous Disease, Chronic
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Haemophilus Infections
Role for NLRP3 Inflammasome-mediated, IL-1?-dependent Responses in Severe, Steroid-resistant Asthma.
Heart Arrest
Cardiac Arrest Disrupts Caspase-1 and Patterns of Inflammatory Mediators Differently in Skin and Muscle Following Localized Tissue Injury in Rats: Insights from Data-Driven Modeling.
Inflammasome and toll-like receptor signaling in human monocytes after successful cardiopulmonary resuscitation.
NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury.
Heart Diseases
Cardiovascular diseases, NLRP3 inflammasome, and western dietary patterns.
Heart Failure
A role for caspase-1 in heart failure.
Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate.
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.
Helicobacter Infections
Caspase-1 Has Both Pro-Inflammatory and Regulatory Properties in Helicobacter Infections, Which Are Differentially Mediated by Its Substrates IL-1? and IL-18.
Hemangioma
Endothelial pyroptosis underlies systemic inflammatory response following radiofrequency ablation of hepatic hemangiomas.
HMGB1-induced endothelial cell pyroptosis is involved in systemic inflammatory response syndrome following radiofrequency ablation of hepatic hemangiomas.
Hematuria
The changes in pyroptosis-related inflammatory factors in the peripheral blood of patients with Henoch-Schonlein purpura.
Hepatitis
Caspase-1 is not involved in experimental hepatitis in mouse.
Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis.
Involvement of Fas/Fas ligand system-mediated apoptosis in the development of concanavalin A-induced hepatitis.
Suppression of inflammatory cascades via novel cinnamic acid nanoparticles in acute hepatitis rat model.
The NLRP3 Inflammasome and IL-1? Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis.
Hepatitis B
AIM2 Mediates Inflammation-Associated Renal Damage in Hepatitis B Virus-Associated Glomerulonephritis by Regulating Caspase-1, IL-1 ? , and IL-18.
Hepatitis B, Chronic
Expression of AIM2 is correlated with increased inflammation in chronic hepatitis B patients.
Hepatitis, Alcoholic
The effect of melaxen on the activity of caspases and the glutathione antioxidant system in toxic liver injury.
Hepatitis, Chronic
Chronic hepatitis in interferon-gamma transgenic mice is associated with elevated CPP32-like activity and interleukin-1beta-converting enzyme activity suppression.
Herpes Simplex
A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe.
Herpes simplex virus type 1 inflammasome activation in proinflammatory human macrophages is dependent on NLRP3, ASC, and caspase-1.
Herpes Zoster
Varicella-Zoster virus infection triggers formation of an IL-1{beta} processing inflammasome complex.
HIV Infections
A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis.
Association of cell free mitochondrial DNA and caspase-1 expression with disease severity and ARTs efficacy in HIV infection.
Caspase 1 and caspase 8 in HIV infected patients with and without tuberculosis.
Caspase-1-associated immune activation in an accelerated SIV-infected rhesus macaque model.
Reduced apoptosis by pentoxiphylline among patients with HIV infection.
Hodgkin Disease
Expression of c-FLIP in classic and nodular lymphocyte-predominant Hodgkin lymphoma.
Huntington Disease
Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease.
Increased caspase-2, calpain activations and decreased mitochondrial complex II activity in cells expressing exogenous huntingtin exon 1 containing CAG repeat in the pathogenic range.
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease.
Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant.
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease.
Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia.
Hyperalgesia
A single subcutaneous injection of ozone prevents allodynia and decreases the over-expression of pro-inflammatory caspases in the orbito-frontal cortex of neuropathic mice.
Cytokine involvement in dynorphin-induced allodynia.
Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity.
Involvement of the spinal NALP1 inflammasome in neuropathic pain and aspirin-triggered-15-epi-lipoxin A4 induced analgesia.
Mechanism of Toll-like Receptor 4 on Chronic Post-thoracotomy Pain Via Caspase-1 Activation.
Neuropeptides contribute to peripheral nociceptive sensitization by regulating interleukin-1? production in keratinocytes.
Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain.
Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation.
Soluble epoxide hydrolase inhibitor trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea prevents hyperalgesia through regulating NLRC4 inflammasome-related pro-inflammatory and anti-inflammatory signaling pathways in the lipopolysaccharide-induced pain mouse model.
The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome.
The Role of NF-?B/NLRP3 Inflammasome Signaling Pathway in Attenuating Pyroptosis by Melatonin Upon Spinal Nerve Ligation Models.
Hypercholesterolemia
Coronary Endothelial Dysfunction Induced by Nlrp3 Inflammasome Activation during Hypercholesterolemia: Beyond Inflammation.
Hyperglycemia
Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB1.
Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue.
Lysosomal Ca
P2Y12 shRNA normalizes inflammatory dysfunctional hepatic glucokinase activity in type 2 diabetic rats.
Peroxynitrite activates NLRP3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia.
The Impact of Acute Ingestion of a Ketone Monoester Drink on LPS-Stimulated NLRP3 Activation in Humans with Obesity.
Tonabersat Inhibits Connexin43 Hemichannel Opening and Inflammasome Activation in an In Vitro Retinal Epithelial Cell Model of Diabetic Retinopathy.
[Impact and related mechanism on the improvement of hyperglycemia-induced pyroptosis in H9c2 cells by mircoRNA-214].
Hyperhomocysteinemia
Contribution of guanine nucleotide exchange factor Vav2 to NLRP3 inflammasome activation in mouse podocytes during hyperhomocysteinemia.
Hyperinsulinism
Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR-/-.Leiden mice.
Hyperlipidemias
Caspase-1 mediates hyperlipidemia-weakened progenitor cell vessel repair.
Corosolic Acid Attenuates Hepatic Lipid Accumulation and Inflammatory Response via AMPK/SREBPs and NF- ? B/MAPK Signaling Pathways.
Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 Pathway.
Hypersensitivity
A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome.
Beneficial effects of chelidonic acid on a model of allergic rhinitis.
Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial Pyroptosis by Activating the NF-?B Signaling Pathway.
Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide.
Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
NLRP2 inflammasome in dorsal root ganglion as a novel molecular platform that produces inflammatory pain hypersensitivity.
Schisandra chinensis and Its Main Constituent Schizandrin Attenuate Allergic Reactions by Down-Regulating Caspase-1 in Ovalbumin-Sensitized Mice.
Hypertension
Analysis of inflammatory mediators in type 2 diabetes patients.
Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice.
Mesenchymal stem cell transplantation inhibited high salt-induced activation of the NLRP3 inflammasome in the renal medulla in Dahl S rats.
Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress.
Mizoribine Ameliorates Renal Injury and Hypertension along with the Attenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats.
NF-?B Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1.
Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress.
T-lymphocyte Kv1.3 channel activation triggers the NLRP3 inflammasome signaling pathway in hypertensive patients.
Hypertension, Pulmonary
Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice.
Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension.
Hypothyroidism
HYPOTHYROIDISM INCREASES EXPRESSION OF STERILE INFLAMMATION PROTEINS IN RAT HEART TISSUE.
Hypoxia, Brain
Temporal Changes in Caspase-1 and Caspase-8 Activities Following Brain Hypoxia With and Without Src kinase Inhibition in a Piglet Animal Model.
Immune System Diseases
The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.
Transient Receptor Potential Melastatin 2 Negatively Regulates LPS-ATP-Induced Caspase-1-Dependent Pyroptosis of Bone Marrow-Derived Macrophage by Modulating ROS Production.
Infarction, Middle Cerebral Artery
Acacetin protects against cerebral ischemia-reperfusion injury via the NLRP3 signaling pathway.
Caspase-1-independent maturation of IL-1? in Ischemic Brain Injury: is there a role for gelatinases?
Early NFkappaB activation is inhibited during focal cerebral ischemia in interleukin-1beta-converting enzyme deficient mice.
Inhibition of Caspase-1 Ameliorates Ischemia-Associated Blood-Brain Barrier Dysfunction and Integrity by Suppressing Pyroptosis Activation.
Interleukin-18 expression after focal ischemia of the rat brain: association with the late-stage inflammatory response.
Role of microglial and endothelial CD36 in post-ischemic inflammasome activation and interleukin-1?-induced endothelial activation.
Infections
?-arrestin1 Is Critical for the Full Activation of NLRP3 and NLRC4 Inflammasomes.
A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome.
A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1? Release in Response to a Pathogenic Fungus.
A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.
A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe.
A novel role for neutrophils as critical activators of NK cells.
A role for Nod-like receptors in autophagy induced by Shigella infection.
A Yersinia effector with enhanced inhibitory activity on the NF-?B pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages.
Acidosis potentiates the host proinflammatory interleukin-1? response to Pseudomonas aeruginosa infection.
Activation of autophagy by inflammatory signals limits IL-1? production by targeting ubiquitinated inflammasomes for destruction.
Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia.
Activation of inflammasomes in adipose tissue of women with gestational diabetes.
Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain.
Activation of Interleukin-1? Release and Pyroptosis by Transmissible Gastroenteritis Virus Is Dependent on the NOD-Like Receptor Protein 3 Inflammasome in Porcine Intestinal Epithelial Cell Line.
Activation of Interleukin-1? Release by the Classical Swine Fever Virus Is Dependent on the NLRP3 Inflammasome, Which Affects Virus Growth in Monocytes.
Activation of murine invariant NKT cells promotes susceptibility to candidiasis by IL-10 induced modulation of phagocyte antifungal activity.
Activation of NLRP3 inflammasome in human neutrophils by Helicobacter pylori infection.
Activation of the Nlrp1b inflammasome by reduction of cytosolic ATP.
Activation of the NLRP3 inflammasome by group B streptococci.
Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF-{kappa}B Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor.
Adenosine synthase A contributes to recurrent Staphylococcus aureus infection by dampening protective immunity.
Adenovirus membrane penetration activates the NLRP3 inflammasome.
Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators.
Aggravated MRSA pneumonia secondary to influenza A virus infection is derived from decreased expression of IL-1?.
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.
AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome.
AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality.
Alternative Pathways of IL-1 Activation, and Its Role in Health and Disease.
ALV-J infection induces chicken monocyte death accompanied with the production of IL-1? and IL-18.
An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection.
An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis.
An Update on CARD Only Proteins (COPs) and PYD Only Proteins (POPs) as Inflammasome Regulators.
Analysis of human bronchial epithelial cell proinflammatory response to Burkholderia cenocepacia infection: inability to secrete il-1?.
Analysis of Inflammasome Activation in Response to Yersinia Infection by Fluorescence Microscopy Detection of Active Caspase-1 Puncta.
Analyzing caspase-1 activation during Legionella pneumophila infection in macrophages.
Anti-Inflammatory Activity of PYNOD and Its Mechanism in Humans and Mice.
Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes.
Apoptosis-Associated Speck-like Protein Containing a Caspase Recruitment Domain Inflammasomes Mediate IL-1? Response and Host Resistance to Trypanosoma cruzi Infection.
Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila.
ASC Controls IFN-? Levels in an IL-18-Dependent Manner in Caspase-1-Deficient Mice Infected with Francisella novicida.
Asc Modulates the Function of NLRC4 in Response to Infection of Macrophages by Legionella pneumophila.
Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages.
ASC-particle-induced Peritonitis.
ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection.
ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming.
Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase.
AT-533, a Hsp90 inhibitor, attenuates HSV-1-induced inflammation.
Avian leukosis virus subgroup J triggers caspase-1-mediated inflammatory response in chick livers.
Avoidance of the NLRP3 Inflammasome by the Stealth Pathogen, Coxiella burnetii.
Bacillus anthracis spores and lethal toxin induce IL-1beta via functionally distinct signaling pathways.
Bacterially induced activation of interleukin-18 in porcine intestinal mucosa.
Baculovirus caspase inhibitors P49 and P35 block virus-induced apoptosis downstream of effector caspase DrICE activation in Drosophila melanogaster cells.
Bovine herpesvirus 1 productive infection stimulates inflammasome formation and caspase 1 activity.
Brd4 regulates NLRC4 inflammasome activation by facilitating IRF8-mediated transcription of Naips.
C10X polymorphism in the CARD8 gene is associated with bacteraemia.
cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection.
Candida albicans triggers NLRP3-mediated pyroptosis in macrophages.
Canonical Inflammasomes Drive IFN-? to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.
Caspase activation may be associated with Mycobacterium avium pathogenicity.
Caspase Exploitation by Legionella pneumophila.
Caspase-1 activation is increased with human labour in foetal membranes and myometrium and mediates infection-induced interleukin-1? secretion.
Caspase-1 Activation Protects Lung Endothelial Barrier Function During Infection-induced Stress.
Caspase-1 Activity in CD4 T Cells Is Downregulated Following Antiretroviral Therapy for HIV-1 Infection.
Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.
Caspase-1 builds a new barrier to infection.
Caspase-1 but Not Caspase-11 Is Required for NLRC4-Mediated Pyroptosis and Restriction of Infection by Flagellated Legionella Species in Mouse Macrophages and In Vivo.
Caspase-1 cleavage of the TLR adaptor TRIF inhibits autophagy and ?-interferon production during Pseudomonas aeruginosa infection.
Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection.
Caspase-1 dependent IL-1? secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection.
Caspase-1 from the silkworm, Bombyx mori, is involved in Bombyx mori nucleopolyhedrovirus infection.
Caspase-1 Has Both Pro-Inflammatory and Regulatory Properties in Helicobacter Infections, Which Are Differentially Mediated by Its Substrates IL-1? and IL-18.
Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo.
Caspase-1 independent viral clearance and adaptive immunity against mucosal respiratory syncytial virus infection.
Caspase-1 inflammasomes in infection and inflammation.
Caspase-1 inhibits IFN-? production via cleavage of cGAS during M. bovis infection.
Caspase-1-associated immune activation in an accelerated SIV-infected rhesus macaque model.
Caspase-1-Dependent and -Independent Cell Death Pathways in Burkholderia pseudomallei Infection of Macrophages.
Caspase-1-independent interleukin-1? is required for clearance of Bordetella pertussis infections and whole-cell vaccine-mediated immunity.
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.
Caspase-1-processed IL-1 family cytokines play a vital role in driving innate IL-17.
Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance.
Caspase-11 Contributes to Oviduct Pathology during Genital Chlamydia Infection in Mice.
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.
Caspase-11 protects against bacteria that escape the vacuole.
Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18.
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.
Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12.
Caspases as the Key Effectors of Inflammatory Responses Against Bacterial Infection.
Caspases-1 and caspase-11 mediate pyroptosis, inflammation, and control of Brucella joint infection.
Catechins and Sialic Acid Attenuate Helicobacter pylori-Triggered Epithelial Caspase-1 Activity and Eradicate Helicobacter pylori Infection.
Cellular localization of NLRP3 inflammasome.
Characterisation of a clinical isolated Aspergillus lentulus strain using a Galleria mellonella infection model.
Characterization of the Japanese flounder NLRP3 inflammasome in restricting Edwardsiella piscicida colonization in vivo.
Chemotaxis-Instructed Intracellular Staphylococcus aureus Infection Detection by a Targeting and Self-Assembly Signal-Enhanced Photoacoustic Probe.
Chlamydia muridarum Infection of Macrophages Stimulates IL-1? Secretion and Cell Death via Activation of Caspase-1 in an RIP3-Independent Manner.
Chlamydia trachomatis infection of epithelial cells induces the activation of caspase-1 and release of mature IL-18.
Chlamydia trachomatis mouse pneumonitis lung infection in IL-18 and IL-12 knockout mice: IL-12 is dominant over IL-18 for protective immunity.
Chlamydial Infection of Monocytes Stimulates IL-1beta Secretion Through Activation of the NLRP3 Inflammasome.
Cholesterol is required to trigger caspase-1 activation and macrophage apoptosis after phagosomal escape of Shigella.
Chronic sodium salicylate treatment exacerbates brain neurodegeneration in rats infected with Trypanosoma brucei.
Circulating miRNA 887 is differentially expressed in ARDS and modulates endothelial function.
Classical swine fever virus and p7 protein induce secretion of IL-1? in macrophages.
CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages.
Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein m013.
Comparative proteomic analysis reveals that caspase-1 and serine protease may be involved in silkworm resistance to Bombyx mori nuclear polyhedrosis virus.
Comparison of two mice strains, A/J and C57BL/6, in caspase-1 activity and IL-1beta secretion of macrophage to Mycobacterium leprae infection.
Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV.
Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages.
Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection.
Confinement of caspase-12 proteolytic activity to autoprocessing.
Contradictory roles of Porphyromonas gingivalis gingipains in caspase-1 activation.
Contribution of Fc?RI-associated vesicles to mast cell-macrophage communication following Francisella tularensis infection.
Contribution of flagellin pattern recognition to intestinal inflammation during Salmonella enterica serotype typhimurium infection.
Correcting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotides.
Correlation of inducible nitric oxide synthase (iNOS) inhibition with TNF-?, caspase-1, FasL and TLR-3 in pathogenesis of rabies in mouse model.
Critical involvement of pneumolysin in production of interleukin-1alpha and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro: a novel function of pneumolysin in caspase-1 activation.
Critical role for the AIM2 inflammasome during acute CNS bacterial infection.
Critical Role for the NLRP3 Inflammasome in Mediating IL-1? Production in Shigella sonnei-Infected Macrophages.
Critical Role of ASC Inflammasomes and Bacterial Type IV Secretion System in Caspase-1 Activation and Host Innate Resistance to Brucella abortus Infection.
Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.
Crystal structure of NALP3 protein pyrin domain (PYD) and its implications in inflammasome assembly.
Cutting edge: IL-1? processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1.
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf.
Cytosolic, autocrine alpha-1 proteinase inhibitor (A1PI) inhibits caspase-1 and blocks IL-1? dependent cytokine release in monocytes.
Cytotoxicity and interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells.
Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages.
Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome.
Dengue virus-infected human monocytes trigger late activation of caspase-1, which mediates pro-inflammatory IL-1? secretion and pyroptosis.
Detection of cytosolic bacteria by inflammatory caspases.
Differential expression profiles of apoptosis-affecting genes in HIV-infected cell lines and patient T cells.
Differential inflammasome activation signatures following intracellular infection of human macrophages with Mycobacterium bovis BCG or Trypanosoma cruzi.
Differential Regulation of Caspase-1 Activation via NLRP3/NLRC4 Inflammasomes Mediated by Aerolysin and Type III Secretion System during Aeromonas veronii Infection.
Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages.
Differential regulation of inflammatory cytokine secretion by human dendritic cells upon Chlamydia trachomatis infection.
Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing.
Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria.
Differential roles of caspase-1 and caspase-11 in infection and inflammation.
Diphenyl pyrimidine exhibits protective effect on Staphylococcus aureus pneumonia in rat model by targeting NLRP3 expression.
Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor.
Effects of Parvovirus B19 In Vitro Infection on Monocytes from Patients with Systemic Sclerosis: Enhanced Inflammatory Pathways by Caspase-1 Activation and Cytokine Production.
Elevated prostaglandin E2 post-bone marrow transplant mediates interleukin-1?-related lung injury.
Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member, NLRX1.
Enterococcus Faecalis activates NLRP3 inflammasomes leading to increased interleukin-1 beta secretion and pyroptosis of THP-1 macrophages.
Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages.
Enteropathogenic Escherichia coli Uses NleA to Inhibit NLRP3 Inflammasome Activation.
Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice.
Evidence of the involvement of caspase-1 under physiologic and pathologic cellular stress during human pregnancy: a link between the inflammasome and parturition.
Expression of inducible nitric oxide synthase, interleukin-1 and caspase-1 in HIV-1 encephalitis.
Expression of Inflammasome-Associated Proteins in Human Oropharyngeal Squamous Cell Carcinoma.
Expression of Interleukin-18, a Th1 cytokine, in human gastric mucosa is increased in Helicobacter pylori infection.
Fas/CD95-mediated apoptosis of type II cells is blocked by Toxoplasma gondii primarily via interference with the mitochondrial amplification loop.
Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity.
Francisella tularensis: activation of the inflammasome.
Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation.
Fungal ?-Glucan Activates the NLRP3 Inflammasome in Human Bronchial Epithelial Cells Through ROS Production.
Fusobacterium nucleatum infection of gingival epithelial cells leads to NLRP3 inflammasome-dependent secretion of IL-1? and the danger signals ASC and HMGB1.
Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against Francisella novicida.
Gasdermin D: Evidence of pyroptosis in spontaneous preterm labor with sterile intra-amniotic inflammation or intra-amniotic infection.
Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila.
Genetic susceptibility and caspase activation in mouse and human macrophages are distinct for Legionella longbeachae and L. pneumophila.
Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1.
Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection.
HCV Induces Telomerase Reverse Transcriptase, Increases Its Catalytic Activity, and Promotes Caspase Degradation in Infected Human Hepatocytes.
HIV-1 infection induces interleukin-1? production via TLR8 protein-dependent and NLRP3 inflammasome mechanisms in human monocytes.
HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation.
Host-dependent trigger of caspases and apoptosis by Legionella pneumophila.
Human cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection.
Human monocytes kill Shigella flexneri but then die by apoptosis associated with suppression of proinflammatory cytokine production.
HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection.
Hyperexpression of type III secretion system of Salmonella Typhi linked to a higher cytotoxic effect to monocyte-derived macrophages by activating inflammasome.
Identification and validation of uterine stimulant methylergometrine as a potential inhibitor of caspase-1 activation.
Identification of a novel IL-1 cytokine family member in teleost fish.
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
IFN-alpha receptor deficiency enhances host resistance to oral Salmonella enterica serovar Typhimurium infection during murine pregnancy.
IKK? negatively regulates ASC-dependent inflammasome activation.
IL-18 triggered by the Nlrp3 inflammasome induces host innate resistance in a pulmonary model of fungal infection.
IL-1? activation in response to Staphylococcus aureus lung infection requires inflammasome-dependent and independent mechanisms.
IL-1? and IL-18 Inhibition of HIV-1 Replication in Jurkat Cells and PBMCs.
IL-1?, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis.
IL-1beta processing in host defense: beyond the inflammasomes.
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.
Immunization with recombinant Salmonella expressing SspH2-EscI protects mice against wild type Salmonella infection.
Impact of caspase-1/11, -3, -7, or IL-1?/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease.
Impaired NLRP3 inflammasome activity during fetal development regulates IL-1? production in human monocytes.
Impaired NLRP3 Inflammasome Function in Elderly Mice during Influenza Infection Is Rescued by Treatment with Nigericin.
Induction of apoptosis by baculovirus transactivator IE1.
Induction of macrophage pyroptosis-related factors by pathogenic E. coli high pathogenicity island (HPI) in Yunnan Saba pigs.
Inflammasome activation in mouse inner ear in response to MCMV induced hearing loss.
Inflammasome activation is required for human rhinovirus-induced airway inflammation in naive and allergen-sensitized mice.
Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling and anti-malaria immunity.
Inflammasome Adaptor Protein Apoptosis-Associated Speck-Like Protein Containing CARD (ASC) Is Critical for the Immune Response and Survival in West Nile Virus Encephalitis.
Inflammasome components caspase-1 and adaptor protein apoptosis-associated speck-like proteins are important in resistance to Cryptosporidium parvum.
Inflammasome components coordinate autophagy and pyroptosis as macrophage responses to infection.
Inflammasome Priming by Lipopolysaccharide Is Dependent upon ERK Signaling and Proteasome Function.
Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment.
Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis.
Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1? is deleterious.
Inflammasomes in inflammatory bowel disease pathogenesis.
Inflammasomes: caspase-1-activating platforms with critical roles in host defense.
Inflammatory signaling in dengue-infected platelets requires translation and secretion of nonstructural protein 1.
Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1beta and 18.
Influenza A viruses limit NLRP3-NEK7-complex formation and pyroptosis in human macrophages.
Initiation and perpetuation of NLRP3 inflammasome activation and assembly.
Innate immune detection of flagellin positively and negatively regulates salmonella infection.
Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome.
Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis.
Interaction of macrophages with a cytotoxic Serratia liquefaciens human isolate.
Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation.
Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice.
Interleukin-1beta responses to Mycoplasma pneumoniae infection are cell-type specific.
Interleukin-1beta-converting enzyme-deficient mice resist central but not systemic endotoxin-induced anorexia.
Intracellular invasion of Orientia tsutsugamushi activates inflammasome in asc-dependent manner.
Intracellular type III secretion by cytoplasmic Shigella flexneri promotes caspase-1-dependent macrophage cell death.
Intracytosolic Listeria monocytogenes induces cell death through caspase-1 activation in murine macrophages.
Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes.
Involvement of caspase-1 in inflammasomes activation and bacterial clearance in S. aureus-infected osteoblasts-like MG-63 cells.
Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection.
Involvement of major components from Sporothrix schenckii cell wall in the caspase-1 activation, nitric oxide and cytokines production during experimental sporotrichosis.
IQGAP1 is important for activation of caspase-1 in macrophages and is targeted by Yersinia pestis type III effector YopM.
IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation.
Isolated perfused udder model for transcriptome analysis in response to Streptococcus agalactiae.
Kaposi's Sarcoma-Associated Herpesvirus Latency in Endothelial and B Cells Activates Gamma Interferon-Inducible Protein 16-Mediated Inflammasomes.
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.
Leishmania donovani evades Caspase 1 dependent host defense mechanism during infection.
Leishmania infantum infection reduces the amyloid ?42-stimulated NLRP3 inflammasome activation.
Longitudinal changes in plasma Caspase-1 and Caspase-3 during the first 2 years of HIV-1 infection in CD4Low and CD4High patient groups.
Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation.
Macrophage activation redirects yersinia-infected host cell death from apoptosis to caspase-1-dependent pyroptosis.
Macrophage Apoptosis Triggered by IpaD from Shigella flexneri.
Macrophage priming is dispensable for NLRP3 inflammasome activation and restriction of Leishmania amazonensis replication.
Measuring NLR Oligomerization I: Size Exclusion Chromatography, Co-immunoprecipitation, and Cross-Linking.
Mechanisms of unconventional secretion of IL-1 family cytokines.
Mechanistic Insight Into the Activation of the NLRP3 Inflammasome by Neisseria gonorrhoeae in Macrophages.
Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response.
Metabolic dysfunction in lymphocytes promotes postoperative morbidity.
Methicillin-resistant Staphylococcus aureus adaptation to human keratinocytes.
MicroRNA-133b Ameliorates Allergic Inflammation and Symptom in Murine Model of Allergic Rhinitis by Targeting Nlrp3.
Microvesicular caspase-1 mediates lymphocyte apoptosis in sepsis.
Mint3 depletion-mediated glycolytic and oxidative alterations promote pyroptosis and prevent the spread of Listeria monocytogenes infection in macrophages.
Modeling the Slow CD4+ T Cell Decline in HIV-Infected Individuals.
Modulation of caspases and their non-apoptotic functions by Legionella pneumophila.
Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: the first identification of an inflammatory caspase in fish.
Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection.
Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1? Production upon Extrinsic Stimulation in Culture.
Mycobacterium tuberculosis infection causes different levels of apoptosis and necrosis in human macrophages and alveolar epithelial cells.
Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome.
Mycophenolic Acid Synergizing with Lipopolysaccharide to Induce Interleukin-1? Release via Activation of Caspase-1.
NALPs: a novel protein family involved in inflammation.
Neutrophil Caspase-11 Is Required for Cleavage of Caspase-1 and Secretion of IL-1? in Aspergillus fumigatus Infection.
Neutrophil IL-1? Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+ Efflux.
Next-Generation mRNA Sequencing Reveals Pyroptosis-Induced CD4+ T Cell Death in Early Simian Immunodeficiency Virus-Infected Lymphoid Tissues.
NLRC4 inflammasome-mediated production of IL-1? modulates mucosal immunity in the lung against gram-negative bacterial infection.
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.
Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen.
NLRP3 Controls Trypanosoma cruzi Infection through a Caspase-1-Dependent IL-1R-Independent NO Production.
NLRP3 deficiency exacerbates enterovirus infection in mice.
NLRP3 in?ammasome mediates chronic intermittent hypoxia-induced renal injury implication of the microRNA-155/FOXO3a signaling pathway.
NLRP3 inflammasome activation and cell death.
NLRP3 inflammasome activation and oxidative stress status in the mild and moderate SARS-CoV-2 infected patients: impact of melatonin as a medicinal supplement.
NLRP3 inflammasome activation by Paracoccidioides brasiliensis.
NLRP3 inflammasome activation in murine macrophages caused by Neospora caninum infection.
NLRP3 Inflammasome Activation in THP-1 Target Cells Triggered by Pathogenic Naegleria fowleri.
NLRP3 Inflammasome Participates in Host Response to Neospora caninum Infection.
NLRP3, NLRP12, and IFI16 Inflammasomes Induction and Caspase-1 Activation Triggered by Virulent HSV-1 Strains Are Associated With Severe Corneal Inflammatory Herpetic Disease.
NLRs, inflammasomes, and viral infection.
Non-classical proIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent.
NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages.
Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death.
Oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages.
P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation.
P2X7 receptor mediates NLRP3-dependent IL-1? secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells.
P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1? Secretion.
PAD2 Mediates Caspase-1 Associated Lethality in Pseudomonas Aeruginosa Pneumonia Induced Sepsis.
Pannexin 1 channels contribute to IL-1? expression via NLRP3/Caspase-1 inflammasome in Aspergillus fumigatus keratitis.
Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappaB signaling.
Pattern-recognition receptors and gastric cancer.
Phosphorylation of NLRC4 is critical for inflammasome activation.
Physical Activity and Bone Health: What Is the Role of Immune System? A Narrative Review of the Third Way.
Porphyromonas gingivalis attenuates ATP-mediated inflammasome activation and HMGB1 release through expression of a nucleoside-diphosphate kinase.
Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking.
Pro-inflammatory caspase-1 activation during the immune response in cells from rainbow trout Oncorhynchus mykiss (Walbaum 1792) challenged with pathogen-associated molecular patterns.
Production of IL-1? and Inflammasome with Up-Regulated Expressions of NOD-Like Receptor Related Genes in Toxoplasma gondii-Infected THP-1 Macrophages.
Progress in inflammasome activation and pyrolysis in alcoholic liver disease.
Prostaglandin E2 produced following infection with Theiler's virus promotes the pathogenesis of demyelinating disease.
Protection against CD95-induced apoptosis by chlamydial infection at a mitochondrial step.
Proteomics-based functional studies reveal that galectin-3 plays a protective role in the pathogenesis of intestinal Behçet's disease.
Pseudomonas aeruginosa activates caspase 1 through Ipaf.
Pyrin critical to macrophage IL-1beta response to Francisella challenge.
Pyroptosis induced by enterovirus 71 and coxsackievirus B3 infection affects viral replication and host response.
Pyroptosis induced by enterovirus A71 infection in cultured human neuroblastoma cells.
Quercetin suppresses NLRP3 inflammasome activation in epithelial cells triggered by Escherichia coli O157:H7.
RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly.
Real-Time Induction of Macrophage Apoptosis, Pyroptosis, and Necroptosis by Enterococcus faecalis OG1RF and Two Root Canal Isolated Strains.
Recent insights into the regulatory networks of NLRP3 inflammasome activation.
Regulating caspase-1 during infection: roles of NLRs, AIM2, and ASC.
Regulation of apoptosis and anti-apoptosis signalling by Francisella tularensis.
Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.
Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice.
Respiratory syncytial virus infection of human alveolar epithelial cells enhances interferon regulatory factor 1 and interleukin-1beta-converting enzyme gene expression but does not cause apoptosis.
Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemia.
Role of francisella lipid a phosphate modification in virulence and long-term protective immune responses.
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis.
Role of the inflammasome-related cytokines Il-1 and Il-18 during infection with murine coronavirus.
Role of the NLRP3 inflammasome in a model of acute burn-induced pain.
Salmonella and Caspase-1: A complex Interplay of Detection and Evasion.
Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes.
Salmonella Promotes ASC Oligomerization-dependent Caspase-1 Activation.
SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death.
SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release.
Secretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by Candida albicans in Mice.
Selective Deletion of CD8(+) Cells Upregulated by Caspases-1 via IL-18 in Mice Immunized with Major Outer Membrane Protein of Shigella dysenteriae 1 Following Infection.
Seneca Valley Virus 3C Protease Induces Pyroptosis by Directly Cleaving Porcine Gasdermin D.
Sequence-specific solid-state NMR assignments of the mouse ASC PYRIN domain in its filament form.
Sf-Caspase-1-repressed stable cells: resistance to apoptosis and augmentation of recombinant protein production.
Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression.
Short-lived AIM2 Inflammasome Activation Relates to Chronic MCMV Infection in BALB/c Mice.
Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages.
Significant Role of IL-1 Signaling, but Limited Role of Inflammasome Activation, in Oviduct Pathology during Chlamydia muridarum Genital Infection.
Single nucleotide polymorphisms of interleukin-1 beta related genes and their associations with infection in the horse.
Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.
SQSTM1/p62/A170 regulates the severity of Legionella pneumophila pneumonia by modulating inflammasome activity.
Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular.
Staphylococcus epidermidis from prosthetic joint infections induces lower IL-1? release from human neutrophils than isolates from normal flora.
Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia.
Subversion of human intestinal mucosa innate immunity by a Crohn's disease-associated E. coli.
Synergistic Costimulatory Effect of Chlamydia pneumoniae with Carbon Nanoparticles on NLRP3 Inflammasome-Mediated Interleukin-1? Secretion in Macrophages.
Syphilitic infection impairs immunity by inducing both apoptosis and pyroptosis of CD4+ and CD8+ T lymphocytes.
Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes.
TGF-?1 signaling inhibit the in vitro apoptotic, infection and stimulatory cell response induced by influenza H1N1 virus infection on A549 cells.
TGFbeta directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes.
The adaptor ASC exacerbates lethal Listeria monocytogenes infection by mediating IL-18 production in an inflammasome-dependent and -independent manner.
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis.
The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock.
The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes.
The H7N9 influenza A virus infection results in lethal inflammation in the mammalian host via the NLRP3-caspase-1 inflammasome.
The human apoptosis inhibitor NAIP induces pyroptosis in macrophages infected with Legionella pneumophila.
The in vitro Mycobacterium bovis BCG Moreau infection of human monocytes that induces Caspase-1 expression, release and dependent cell death is mostly reliant upon cell integrity.
The Inflammasome in Reproductive Biology: A Promising Target for Novel Therapies.
The Inflammasome in Times of COVID-19.
The interleukin-1 system in gestational tissues at term: effect of labour.
The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity.
The NAIP/NLRC4 inflammasomes.
The neutrophil NLRC4 inflammasome selectively promotes IL-1? maturation without pyroptosis during acute Salmonella challenge.
The Nlrc4 Inflammasome Contributes to Restriction of Pulmonary Infection by Flagellated Legionella spp. that Trigger Pyroptosis.
The NLRP3 inflammasome detects EMCV and VSV infection.
The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus.
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation.
The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection.
The non-receptor tyrosine kinase Tec controls assembly and activity of the noncanonical caspase-8 inflammasome.
The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation.
The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.
The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.
The role of interleukin-converting enzyme in Fas-mediated apoptosis in HIV-1 infection.
The role of NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection.
The role of the NLRP3 inflammasome in regulation of antiviral responses to influenza A virus infection.
The Roles of Inflammasomes in Host Defense against Mycobacterium tuberculosis.
The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation.
The Viral Tegument Protein pp65 Impairs Transcriptional Upregulation of IL-1? by Human Cytomegalovirus through Inhibition of NF-kB Activity.
TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis.
TLR2 and caspase-1 signaling are critical for bacterial containment but not clearance during craniotomy-associated biofilm infection.
TLR2 and Nod2 Mediate Resistance or Susceptibility to Fatal Intracellular Ehrlichia Infection in Murine Models of Ehrlichiosis.
TLR2/MyD88/NF-?B pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection.
Transcriptional analysis of THP-1 cells infected with Leishmania infantum indicates no activation of the inflammasome platform.
Transcriptional profiling identifies caspase-1 as a T cell-intrinsic regulator of Th17 differentiation.
Type I interferon contributes to noncanonical inflammasome activation, mediates immunopathology, and impairs protective immunity during fatal infection with lipopolysaccharide-negative ehrlichiae.
Uncovering an Important Role for YopJ in the Inhibition of Caspase-1 in Activated Macrophages and Promoting Yersinia pseudotuberculosis Virulence.
Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation.
Vibrio pore-forming leukocidin activates pyroptotic cell death via the NLRP3 inflammasome.
Virulence factors encoded by Legionella longbeachae identified on the basis of the genome sequence analysis of clinical isolate D-4968.
Virulent Mycobacterium bovis Beijing Strain Activates the NLRP7 Inflammasome in THP-1 Macrophages.
VPEgamma exhibits a caspase-like activity that contributes to defense against pathogens.
WDR90 is a new component of the NLRC4 inflammasome involved in Salmonella Typhimurium resistance.
White spot syndrome virus infection activates Caspase 1-mediated cell death in crustacean.
YopJ-induced caspase-1 activation in Yersinia-infected macrophages: independent of apoptosis, linked to necrosis, dispensable for innate host defense.
[Caspase-1 regulates autoinflammation in rheumatic diseases].
[Immunopathological mechanism of spleen damage in acute disseminated MCMV infection].
Infertility
Prevention of Chlamydia-induced infertility by inhibition of local caspase activity.
Sperm caspases become more activated in infertility patients than in healthy donors during cryopreservation.
Inflammatory Bowel Diseases
Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential.
Emerging views of mitophagy in immunity and autoimmune diseases.
Probiotic Escherichia coli Nissle 1917 and Commensal E. coli K12 Differentially Affect the Inflammasome in Intestinal Epithelial Cells.
Influenza, Human
Caspase 3 activation is essential for efficient influenza virus propagation.
Caspase-1 Deficient Mice Are More Susceptible to Influenza A Virus Infection With PA Variation.
IL-36 receptor deletion attenuates lung injury and decreases mortality in murine influenza pneumonia.
Impaired NLRP3 Inflammasome Function in Elderly Mice during Influenza Infection Is Rescued by Treatment with Nigericin.
Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1beta and 18.
Influenza enhances caspase-1 in bronchial epithelial cells from asthmatic volunteers and is associated with pathogenesis.
Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression.
Protective immunity to influenza: lessons from the virus for successful vaccine design.
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.
The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1? Secretion.
Insulin Resistance
Activation of inflammasomes in adipose tissue of women with gestational diabetes.
Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
Caspases and inflammasomes in metabolic inflammation.
Differential Impact of Weight Loss and Glycemic Control on Inflammasome Signaling.
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels.
Effects of exercise training on inflammasome-related mediators and their associations to glucometabolic variables in patients with combined coronary artery disease and type 2 diabetes mellitus: Sub-study of a randomized control trial.
Eicosapentaenoic Acid Regulates Inflammatory Pathways through Modulation of Transcripts and miRNA in Adipose Tissue of Obese Mice.
Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans.
Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue.
Increased inflammasome activity in subcutaneous adipose tissue of patients with metabolic syndrome.
Inflammasome is a central player in the induction of obesity and insulin resistance.
Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family.
Interleukin-1beta may mediate insulin resistance in liver-derived cells in response to adipocyte inflammation.
Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR-/-.Leiden mice.
Monounsaturated Fatty Acid-Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome-Mediated IL-1? Secretion and Insulin Resistance Despite Obesity.
Serum Caspase-1 levels in women with polycystic ovary syndrome.
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity.
[Expression of NLRP1 inflammasomes in myocardial tissue of diabetic rats].
Intervertebral Disc Degeneration
Enhanced NLRP3, caspase-1, and IL- 1? levels in degenerate human intervertebral disc and their association with the grades of disc degeneration.
Intervertebral Disc Displacement
A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome.
Intestinal Diseases
Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential.
Intracranial Aneurysm
Increased Expression of NLRP3 Inflammasome in Wall of Ruptured and Unruptured Human Cerebral Aneurysms: Preliminary Results.
Ischemic Attack, Transient
Immunohistochemical investigation of caspase-1 and effect of caspase-1 inhibitor in delayed neuronal death after transient cerebral ischemia.
Ischemic Stroke
Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke.
Caspase-1 inhibition mediates neuroprotection in experimental stroke by polarizing M2 microglia/macrophage and suppressing NF-?B activation.
Hypoxia Inducible Factor-1? (HIF-1?) Mediates NLRP3 Inflammasome-Dependent-Pyroptotic and Apoptotic Cell Death Following Ischemic Stroke.
Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia.
Peroxynitrite activates NLRP3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia.
Keloid
Interleukin-18 system plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions.
Regulation of glycolysis and the Warburg effect in wound healing.
Keratitis
Caspase-1 inhibitor reduces severity of pseudomonas aeruginosa keratitis in mice.
NLRC4 regulates caspase-1 and IL-1beta production in a CD11blowLy6Glow population of cells required for resistance to Pseudomonas aeruginosa keratitis.
Kernicterus
Depression of Pyroptosis by Inhibiting Caspase-1 Activation Improves Neurological Outcomes of Kernicterus Model Rats.
Ketosis
Hepatic nuclear factor kappa B signaling pathway and NLR family pyrin domain containing 3 inflammasome is over-activated in ketotic dairy cows.
Oxidative stress, NF-?B signaling, NLRP3 inflammasome, and caspase apoptotic pathways are activated in mammary gland of ketotic Holstein cows.
Kidney Calculi
Atorvastatin inhibits renal inflammatory response induced by calcium oxalate crystals via inhibiting the activation of TLR4/NF-?B and NLRP3 inflammasome.
Kidney Diseases
Purinergic 2X7 Receptor is Involved in the Podocyte Damage of Obesity-Related Glomerulopathy via Activating Nucleotide-Binding and Oligomerization Domain-Like Receptor Protein 3 Inflammasome.
Kidney Neoplasms
An analysis of growth, differentiation and apoptosis genes with risk of renal cancer.
Silencing of the caspase-1 gene occurs in murine and human renal cancer cells and causes solid tumor growth in vivo.
Latent Infection
Generation of a KSHV K13 deletion mutant for vFLIP function study.
Legionnaires' Disease
Analyzing caspase-1 activation during Legionella pneumophila infection in macrophages.
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.
The human apoptosis inhibitor NAIP induces pyroptosis in macrophages infected with Legionella pneumophila.
The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation.
Leiomyoma
Screening of potential biomarkers in uterine leiomyomas disease via gene expression profiling analysis.
Leishmaniasis
Characterization of serum cytokines and circulating microRNAs that are predicted to regulate inflammasome genes in cutaneous leishmaniasis patients.
Leprosy
The inflammasome in leprosy skin lesions: an immunohistochemical evaluation.
Leprosy, Lepromatous
Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae.
The inflammasome in leprosy skin lesions: an immunohistochemical evaluation.
Leukemia
Bifidobacterium breve - HT-29 cell line interaction: modulation of TNF-? induced gene expression.
Caspase-1 and -3 Inhibiting Drimane Sesquiterpenoids from the Extremophilic Fungus Penicillium solitum.
Caspase-1 Inhibitors from an Extremophilic Fungus That Target Specific Leukemia Cell Lines.
Caspase-1 promotes monocyte-macrophage differentiation by repressing PPAR?.
CPT-11 activates NLRP3 inflammasome through JNK and NF-?B signalings.
Differential CD95 expression and function in T and B lineage acute lymphoblastic leukemia cells.
Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells.
Expression and prognosis analyses of CASP1 in acute myeloid leukemia.
Expression of apoptosis-controlling proteins in acute leukemia cells.
Expression of GM-CSF Is Regulated by Fli-1 Transcription Factor, a Potential Drug Target.
Fli-1 transcription factor regulates the expression of caspase-1 in lung pericytes.
Genomic and transcriptomic profiles and in vitro resistance to mitoxantrone and idarubicin in pediatric acute leukemias.
Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation.
Modulation of acute myeloblastic leukemia (AML) cell proliferation and blast colony formation by antisense oligomer for IL-1 beta converting enzyme (ICE) and IL-1 receptor antagonist (IL-1ra).
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.
NLRP3 Inflammasome Promotes the Progression of Acute Myeloid Leukemia via IL-1? Pathway.
Photodynamic therapy induces caspase-3 activation in HL-60 cells.
Role of interleukin-1 beta converting enzyme (ICE) in leukemia.
[The expression and clinical significance of hematopoietic cell phosphatase and cysteinyl aspartate-specific proteinase in leukemia]
Leukemia, B-Cell
NF-kappaB and FLIP in arsenic trioxide (ATO)-induced apoptosis in myelodysplastic syndromes (MDSs).
Leukemia, Erythroblastic, Acute
Elevated NF-kappaB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis.
Leukemia, Monocytic, Acute
Caspase-1 promotes monocyte-macrophage differentiation by repressing PPAR?.
CPT-11 activates NLRP3 inflammasome through JNK and NF-?B signalings.
Leukemia, Myeloid
Stimulation of interleukin-1beta-converting enzyme activity during growth inhibition by CPT-11 in the human myeloid leukemia cell line K562.
Leukemia, Myeloid, Acute
Caspase-1 as a radio- and chemo-sensitiser in vitro and in vivo.
Effect of interleukin-1 beta converting enzyme inhibitor on acute myelogenous leukemia progenitor proliferation.
Expression and prognosis analyses of CASP1 in acute myeloid leukemia.
Modulation of acute myeloblastic leukemia (AML) cell proliferation and blast colony formation by antisense oligomer for IL-1 beta converting enzyme (ICE) and IL-1 receptor antagonist (IL-1ra).
Role of interleukin-1 beta converting enzyme (ICE) in acute myelogenous leukemia cell proliferation and programmed cell death.
Spontaneous down-regulation of Fas-associated phosphatase-1 may contribute to excessive apoptosis in myelodysplastic marrows.
Leukemia-Lymphoma, Adult T-Cell
Relationship between triterpenoid anticancer drug resistance, autophagy, and caspase-1 in adult T-cell leukemia.
Leukoplakia
Sequence and expression variations in 23 genes involved in mitochondrial and non-mitochondrial apoptotic pathways and risk of oral leukoplakia and cancer.
Leukostasis
Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy.
Lichen Planus
The caspase-1 inhibitor CARD18 is specifically expressed during late differentiation of keratinocytes and its expression is lost in lichen planus.
Lichen Planus, Oral
Inflammatory and immune-related factor Caspase 1 contributes to the development of oral lichen planus.
Listeriosis
Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes.
Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection.
Roles of caspase-1 in Listeria infection in mice.
Liver Cirrhosis
Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis.
Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR-/-.Leiden mice.
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.
Obeticholic acid improves hepatic steatosis and inflammation by inhibiting NLRP3 inflammasome activation.
Potentiation of hepatic stellate cell activation by extracellular ATP is dependent on P2X7R-mediated NLRP3 inflammasome activation.
Liver Cirrhosis, Biliary
Emerging views of mitophagy in immunity and autoimmune diseases.
Liver Diseases
Caspase inhibitors: a review of recently patented compounds (2013-2015).
Inhibition of hepatic interleukin-18 production by rosiglitazone in a rat model of nonalcoholic fatty liver disease.
NLRP3 inflammasome activation is required for fibrosis development in NAFLD.
The different expression of caspase-1 in HBV-related liver disease and acts as a biomarker for acute-on-chronic liver failure.
Liver Failure
Pro-inflammatory interleukin-18 and Caspase-1 serum levels in liver failure are unaffected by MARS treatment.
Liver Failure, Acute
Pro-inflammatory interleukin-18 and Caspase-1 serum levels in liver failure are unaffected by MARS treatment.
Lung Diseases
Cdk5-Dependent Activation of Neuronal Inflammasomes in Parkinson's Disease.
Lung Injury
AMPK as a potential pharmacological target for alleviating LPS-induced acute lung injury partly via NLRC4 inflammasome pathway inhibition.
Caspase-1 inhibitor reduced the lung injury in a mouse model of pleuropneumonia caused by Actinobacillus pleuropneumoniae.
Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury by targeting NLRP3 via miR-381.
Dexmedetomidine attenuates ventilator-induced lung injury in rats by up-regulating NLRC3.
Effect and mechanism of phospholipid scramblase 4 (PLSCR4) on lipopolysaccharide (LPS)-induced injury to human pulmonary microvascular endothelial cells.
Evaluation of pulmonary response to inhaled tungsten (IV) oxide nanoparticles in golden Syrian hamsters.
Extracellular mitochondrial DNA promote NLRP3 inflammasome activation and induce acute lung injury through TLR9 and NF-?B.
Glibenclamide alleviates inflammation in oleic acid model of acute lung injury through NLRP3 inflammasome signaling pathway.
Inhibition of Alveolar Macrophage Pyroptosis Reduces Lipopolysaccharide-induced Acute Lung Injury in Mice.
Knockdown of long non-coding RNAs of maternally expressed 3 (lncRNA-MEG3) alleviates hyperoxia-induced lung injury via inhibiting thioredoxin-interacting protein (TXNIP)-mediated pyroptosis by binding to microRNA miR-18a.
Luteolin activates Tregs to promote IL-10 expression and alleviating caspase-11-dependent pyroptosis in sepsis-induced lung injury.
Role of Proinflammatory Cytokine IL-18 and IL-1{beta} in Bleomycin-induced Lung Injury in Humans and Mice.
[Interventional effects of BAY11-7082 on lung inflammatory response at the early stage and acute lung injury of rats with severe burns].
[Regulatory effect of hemichannels protein Pannexin-1 on P2X7 receptor activity in the lungs of mice with lung injury].
Lung Neoplasms
Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism.
Differentially expressed apoptotic genes in early stage lung adenocarcinoma predicted by expression profiling.
G9A promotes tumor cell growth and invasion by silencing CASP1 in non-small-cell lung cancer cells.
Implications of caspase-dependent proteolytic cleavage of cyclin A1 in DNA damage-induced cell death.
Lupus Erythematosus, Systemic
Activation of caspase-1 is mediated by stimulation of interferon genes and NLR family pyrin domain containing 3 in monocytes of active systemic lupus erythematosus.
Emerging views of mitophagy in immunity and autoimmune diseases.
mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus by Impairing Caspase-1 Cleavage of Rab39a.
Polimorphisms in Inflammasome Genes Are Involved in the Predisposition to Systemic Lupus Erythematosus.
Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus.
Lupus Nephritis
Expression and clinical significance of the NEK7-NLRP3 inflammasome signaling pathway in patients with systemic lupus erythematosus.
Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis.
Lyme Disease
Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism.
Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3.
The caspase 1 inflammasome is not required for control of murine Lyme borreliosis.
Lymphatic Metastasis
Loss of caspase-1 gene expression in human gastric carcinomas and cell lines.
Lymphedema
Far-Infrared Radiation Thermotherapy Improves Tissue Fibrosis in Chronic Extremity Lymphedema.
Far-infrared ray for treating chronic lower extremity lymphedema with dermatolymphangioadenitis: a postoperative complication of gynecological tumor resection.
Lymphoma
BCL2 protein signalling determines acute responses to neoadjuvant chemoradiotherapy in rectal cancer.
cFLIP expression correlates with tumour progression and patient outcome in non-Hodgkin lymphomas of low grade of malignancy.
Constitutive NF-kappaB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice.
Mitochondria-dependent caspase-9 activation is necessary for antigen receptor-mediated effector caspase activation and apoptosis in WEHI 231 lymphoma cells.
Lymphoma, B-Cell
Apoptosis in B-cell lymphomas and reactive lymphoid tissues always involves activation of caspase 3 as determined by a new in situ detection method.
BCL2 protein signalling determines acute responses to neoadjuvant chemoradiotherapy in rectal cancer.
Cypermethrin Alters the Expression Profile of mRNAs in the Adult Rat Striatum: A Putative Mechanism of Postnatal Pre-exposure Followed by Adulthood Re-exposure-Enhanced Neurodegeneration.
Insulin and IGF-1 mediated inhibition of apoptosis in CHO cells grown in suspension in a protein-free medium.
Kaposi's Sarcoma-Associated Herpesvirus Latency in Endothelial and B Cells Activates Gamma Interferon-Inducible Protein 16-Mediated Inflammasomes.
YopJ-induced caspase-1 activation in Yersinia-infected macrophages: independent of apoptosis, linked to necrosis, dispensable for innate host defense.
Lymphoma, Follicular
Apoptosis in B-cell lymphomas and reactive lymphoid tissues always involves activation of caspase 3 as determined by a new in situ detection method.
Lymphoma, Primary Effusion
Constitutive NF-kappaB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice.
Lymphoma, T-Cell, Cutaneous
Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma.
Macrophage Activation Syndrome
Systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome due to a CASP1 variant causing inflammasome hyperactivation.
Macular Degeneration
Distinct CD40L receptors mediate inflammasome activation and secretion of IL-1? and MCP-1 in cultured human retinal pigment epithelial cells.
Malaria
Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting NF-kappaB signaling.
Contribution of inflammasome genetics in Plasmodium vivax malaria.
Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Malaria, Cerebral
Caspase-1 Activation of Interleukin-1{beta} (IL-1{beta}) and IL-18 Is Dispensable for Induction of Experimental Cerebral Malaria.
Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome.
Malaria, Vivax
Western blot diagnosis of vivax malaria with multiple stage-specific antigens of the parasite.
Malnutrition
Relation between neonatal malnutrition and gene expression: inflammasome function in infections caused by Candida Albicans.
TLR and NLRP3 inflammasome expression deregulation in macrophages of adult rats subjected to neonatal malnutrition and infected with methicillin-resistant Staphylococcus aureus.
Mastitis
UFL1 modulates NLRP3 inflammasome activation and protects against pyroptosis in LPS-stimulated bovine mammary epithelial cells.
Melanoma
?-arrestin1 Is Critical for the Full Activation of NLRP3 and NLRC4 Inflammasomes.
A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis.
Absent in melanoma 2 triggers a heightened inflammasome response in ascitic fluid macrophages of patients with cirrhosis.
Activation of the Absent in Melanoma 2 Inflammasome in Peripheral Blood Mononuclear Cells From Idiopathic Pulmonary Fibrosis Patients Leads to the Release of Pro-Fibrotic Mediators.
Aggregatibacter actinomycetemcomitans targets NLRP3 and NLRP6 inflammasome expression in human mononuclear leukocytes.
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.
AIM2 deletion promotes neuroplasticity and spatial memory of mice.
AIM2 inflammasome activation may mediate high mobility group box 1 release in murine allergic rhinitis.
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Antiapoptotic role of endogenous nitric oxide in human melanoma cells.
ASC/TMS1, a caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma.
Bcl-2 family proteins and cytoskeleton changes involved in DM-1 cytotoxic effect on melanoma cells.
BECN2 (beclin 2) Negatively Regulates Inflammasome Sensors Through ATG9A-Dependent but ATG16L1- and LC3-Independent Non-Canonical Autophagy.
Brucella abortus Infection Elicited Hepatic Stellate Cell-Mediated Fibrosis Through Inflammasome-Dependent IL-1? Production.
Chinese Propolis Exerts Anti-Proliferation Effects in Human Melanoma Cells by Targeting NLRP1 Inflammatory Pathway, Inducing Apoptosis, Cell Cycle Arrest, and Autophagy.
Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes.
Circulatory CD4-Positive T-Lymphocyte Imbalance Mediated by Homocysteine-Induced AIM2 and NLRP1 Inflammasome Upregulation and Activation Is Associated with Human Abdominal Aortic Aneurysm.
Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta.
Critical role for the AIM2 inflammasome during acute CNS bacterial infection.
Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Differential Activation of NLRP3, AIM2, and IFI16 Inflammasomes in Humans with Acute and Chronic Hepatitis B.
Differential expression of inflammasome regulatory transcripts in periodontal disease.
Do inflammatory pathways drive melanomagenesis?
Dual Role of Apoptosis-Associated Speck-Like Protein Containing a CARD (ASC) in Tumorigenesis of Human Melanoma.
Effects of hyperbaric oxygen on NLRP3 inflammasome activation in the brain after carbon monoxide poisoning.
Effects of pterostilbene on melanoma alone and in synergy with inositol hexaphosphate.
Elevated procaspase levels in human melanoma.
Emerging views of mitophagy in immunity and autoimmune diseases.
Expression of AIM2 is correlated with increased inflammation in chronic hepatitis B patients.
Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against Francisella novicida.
GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals.
Glial Cell-Elicited Activation of Brain Microvasculature in Response to Brucella abortus Infection Requires ASC Inflammasome-Dependent IL-1? Production.
Herpes simplex virus type 1 inflammasome activation in proinflammatory human macrophages is dependent on NLRP3, ASC, and caspase-1.
Histone deacetylase 6 negatively regulates NLRP3 inflammasome activation.
Immunobiology and structural biology of AIM2 inflammasome.
Inflammasomes and its importance in viral infections.
Inhibition of double-strand DNA-sensing cGAS ameliorates brain injury after ischemic stroke.
Insight Into Inflammasome Signaling: Implications for Toxoplasma gondii Infection.
Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes.
Localization and functionality of the inflammasome in neutrophils.
MiR-143 Induces Expression of AIM2 and ASC in Jurkat Cell Line.
NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma.
NLRP3 Inflammasome From Bench to Bedside: New Perspectives for Triple Negative Breast Cancer.
Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4.
Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.
Prostaglandin E2 produced following infection with Theiler's virus promotes the pathogenesis of demyelinating disease.
Proteomic analysis and the antimetastatic effect of N-(4-methyl)phenyl-O-(4-methoxy) phenyl-thionocarbamate-induced apoptosis in human melanoma SK-MEL-28 cells.
Pyroptotic neuronal cell death mediated by the AIM2 inflammasome.
Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review.
Roles of ginsenosides in inflammasome activation.
Serum caspase-1 levels in metastatic melanoma patients: relationship with tumour burden and non-response to biochemotherapy.
Signs of innate immune activation and premature immunosenescence in psoriasis patients.
Streptococcus mutans activates the AIM2, NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages.
Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism.
Syk and JNK signaling pathways are involved in inflammasome activation in macrophages infected with Streptococcus pneumoniae.
The absent in melanoma 2 (AIM2) inflammasome in microbial infection.
The ketone metabolite ?-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
The role of inflammasomes in kidney disease.
The Roles of Inflammasomes in Host Defense against Mycobacterium tuberculosis.
Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome.
Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer's disease.
Type I Interferon Increases Inflammasomes Associated Pyroptosis in the Salivary Glands of Patients with Primary Sjögren's Syndrome.
USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3.
Varicella-Zoster virus infection triggers formation of an IL-1{beta} processing inflammasome complex.
Zika Virus Impairs Host NLRP3-mediated Inflammasome Activation in an NS3-dependent Manner.
[Inflammatory bowel diseases and inflammasome].
Melanoma, Experimental
IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1.
Melioidosis
Caspase-1 mediates resistance in murine melioidosis.
Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18.
Therapeutic Administration of a Monoclonal Anti-Il-1? Antibody Protects Against Experimental Melioidosis.
Memory Disorders
Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to ?-Amyloid peptide accumulation.
Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer's disease mouse model.
Isovitexin modulates autophagy in Alzheimer's disease via miR-107 signalling.
NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide.
NLRP3/Caspase-1 Pathway-Induced Pyroptosis Mediated Cognitive Deficits in a Mouse Model of Sepsis-Associated Encephalopathy.
Meningitis
Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia.
Transcriptional regulation of caspases in experimental pneumococcal meningitis.
Meningitis, Bacterial
Polymorphisms in Toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis.
Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice.
Meningitis, Meningococcal
Single nucleotide polymorphisms in pathogen recognition receptor genes are associated with susceptibility to meningococcal meningitis in a pediatric cohort.
Meningitis, Pneumococcal
Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice.
Single nucleotide polymorphisms in pathogen recognition receptor genes are associated with susceptibility to meningococcal meningitis in a pediatric cohort.
The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release.
Mesothelioma, Malignant
Curcumin: a double hit on malignant mesothelioma.
Metabolic Diseases
Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study.
Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout.
Mevalonate Kinase Deficiency
Specific increase in caspase-1 activity and secretion of IL-1 family cytokines: a putative link between mevalonate kinase deficiency and inflammation.
Microcephaly
In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases.
mitochondrial protein-transporting atpase deficiency
HSP70 is a negative regulator of NLRP3 inflammasome activation.
Molluscum Contagiosum
A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis.
Mouth Neoplasms
Sequence and expression variations in 23 genes involved in mitochondrial and non-mitochondrial apoptotic pathways and risk of oral leukoplakia and cancer.
Mucositis
NOD-Like Receptor Family Pyrin Domain-Containing 3 Inflammasome Activation Exacerbates 5-Fluorouracil-Induced Small Intestinal Mucositis via Interleukin-1? Activation.
Multiple Myeloma
PRMT5 regulates cell pyroptosis by silencing CASP1 in multiple myeloma.
Multiple Sclerosis
Caspase-1 expression in multiple sclerosis plaques and cultured glial cells.
Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis.
Caspase-1 levels in biological fluids from patients with multiple sclerosis and from patients with other neurological and non-neurological diseases.
Correction for McKenzie et al., Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis.
Cutting Edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis.
Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo.
Increased expression of caspase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis.
Peripheral levels of caspase-1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study.
The Effects of IFN-? 1a on the Expression of Inflammasomes and Apoptosis-Associated Speck-Like Proteins in Multiple Sclerosis Patients.
The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18.
Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis.
Multiple Sclerosis, Relapsing-Remitting
Increased Level of Caspase-1 in the Serum of Relapsing-remitting Multiple Sclerosis (RRMS) Patients.
Peripheral levels of caspase-1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study.
Murine Acquired Immunodeficiency Syndrome
Atypical cytomegalovirus retinal disease in pyroptosis-deficient mice with murine acquired immunodeficiency syndrome.
Muscular Diseases
Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy.
Dual effects of caspase-1, interleukin-1 beta, tumour necrosis factor-alpha and nerve growth factor receptor in inflammatory myopathies.
Myasthenia Gravis
Caspase-1 inhibitor ameliorates experimental autoimmune myasthenia gravis by innate dendric cell IL-1-IL-17 pathway.
Caspase-1 inhibitor regulates humoral responses in experimental autoimmune myasthenia gravis via IL-6- dependent inhibiton of STAT3.
Mycoses
Fungal zymosan and mannan activate the cryopyrin inflammasome.
GSDMD, an executor of pyroptosis, is involved in IL-1? secretion in Aspergillus fumigatus keratitis.
Myelitis
Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation.
Myelodysplastic Syndromes
Sequential activation of caspase-1 and caspase-3-like proteases during apoptosis in myelodysplastic syndromes.
Myocardial Infarction
Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury.
Beta-Asarone Alleviates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammatory Response and NLRP3 Inflammasome Mediated Pyroptosis.
Caspase-1 genetic variation is not associated with Alzheimer's disease risk.
Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function.
Caspase-1 mediates hyperlipidemia-weakened progenitor cell vessel repair.
Elevated levels of interleukin-1beta-converting enzyme and caspase-cleaved cytokeratin-18 in acute myocardial infarction.
Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk.
Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury.
Nicorandil inhibits TLR4/MyD88/NF-?B/NLRP3 signaling pathway to reduce pyroptosis in rats with myocardial infarction.
Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia.
Recent insights into the regulatory networks of NLRP3 inflammasome activation.
Targeted deletion of caspase-1 reduces early mortality and left ventricular dilatation following myocardial infarction.
Taurine Alleviates Sympathetic Innervation by Inhibiting NLRP3 Inflammasome in Postinfarcted Rats.
The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway.
The Highly Selective Caspase-1 Inhibitor VX-765 Provides Additive Protection Against Myocardial Infarction in Rat Hearts When Combined With a Platelet Inhibitor.
Myocardial Ischemia
p38 mitogen activated protein kinase mediates both death signaling and functional depression in the heart.
Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia.
Myocardial Reperfusion Injury
Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor.
Myocardial Stunning
Influence of the interleukin-converting enzyme inhibitor HMR-3480 on myocardial stunning in pigs in vivo.
Myocarditis
Virulence of Trypanosoma cruzi Strains Is Related to the Differential Expression of Innate Immune Receptors in the Heart.
Myositis
Dual effects of caspase-1, interleukin-1 beta, tumour necrosis factor-alpha and nerve growth factor receptor in inflammatory myopathies.
Myxoma
Myxoma virus Serp2 is a weak inhibitor of granzyme B and interleukin-1beta-converting enzyme in vitro and unlike CrmA cannot block apoptosis in cowpox virus-infected cells.
Serp2, an inhibitor of the interleukin-1beta-converting enzyme, is critical in the pathobiology of myxoma virus.
Neoplasm Metastasis
c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.
Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.
Detection of proteins associated with the pyroptosis signaling pathway in breast cancer tissues and their significance.
Effect of homeopathic treatment on gene expression in Copenhagen rat tumor tissues.
High mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases.
IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1.
Loss of caspase-1 gene expression in human gastric carcinomas and cell lines.
Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis.
Prognostic Role of Inflammasome Components in Human Colorectal Cancer.
Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer.
[Impact of preoperative drug therapy on the expression of apoptosis markers in colorectal liver metastases].
Neoplasms
?-eudesmol inhibits thymic stromal lymphopoietin through blockade of caspase-1/NF-?B signal cascade in allergic rhinitis murine model.
A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.
A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe.
A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis.
a-Tocopherol modifies the expression of genes related to oxidative stress and apoptosis during invitro maturation and enhances the developmental competence of rabbit oocytes.
A80: Skeletal Features of Neonatal-Onset Multisystem Inflammatory Disease (NOMID) on Anakinra Treatment: Long-Term Follow-up.
Activation of caspase-1 in the nucleus requires nuclear translocation of pro-caspase-1 mediated by its prodomain.
Activation of Pyroptotic Cell Death Pathways in Cancer: An Alternative Therapeutic Approach.
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats.
alpha-fetoprotein causes apoptosis in tumor cells via a pathway independent of CD95, TNFR1 and TNFR2 through activation of caspase-3-like proteases.
An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages.
Anakinra Protects Against Serum Deprivation-Induced Inflammation and Functional Derangement in Islets Isolated From Nonhuman Primates.
Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1?-, IL-18- and sirtuin-1-independent pathways.
Annulus cells from more degenerated human discs show modified gene expression in 3D culture compared with expression in cells from healthier discs.
Anti-allergic and anti-inflammatory effects of the Bcl-2 inhibitor ABT-737 on experimental allergic rhinitis models.
Anti-hepatitis B virus effect of matrine-type alkaloid and involvement of p38 mitogen-activated protein kinase and tumor necrosis factor receptor-associated factor 6.
Anti-hyperuricemic and anti-inflammatory actions of vaticaffinol isolated from Dipterocarpus alatus in hyperuricemic mice.
Anti-inflammatory effect of selenium on lead-induced testicular inflammation by inhibiting NLRP3 inflammasome activation in chickens.
Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation.
Apoptosis induced by differentiation or serum deprivation in an immortalized central nervous system neuronal cell line.
Apoptosis is signalled early by low doses of ionising radiation in a radiation-induced bystander effect.
Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea.
Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS.
Aquilariae Lignum Methylene Chloride Fraction Attenuates IL-1?-Driven Neuroinflammation in BV2 Microglial Cells.
ASC contributes to metastasis of oral cavity squamous cell carcinoma.
ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice.
Association of twelve immune-related genes with performance of three broiler lines in two different hygiene environments.
Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin in?ammation.
Berberine affects osteosarcoma via downregulating the caspase-1/IL-1? signaling axis.
Betulinic acid enhanced the chemical sensitivity of esophageal cancer cells to cisplatin by inducing cell pyroptosis and reducing cell stemness.
Bioactive secondary metabolites from acid mine waste extremophiles.
Blockade of tumor necrosis factor-? converting enzyme (TACE) enhances IL-1? and IFN-? via caspase-1 activation: A probable cause for loss of efficacy of TACE inhibitors in humans?
Blocking ERK-1/2 reduces tumor necrosis factor alpha-induced interleukin-18 bioactivity in rheumatoid arthritis synovial fibroblasts by induction of interleukin-18 binding protein A.
Blocking the janus-activated kinase pathway reduces tumor necrosis factor alpha-induced interleukin-18 bioactivity by caspase-1 inhibition.
Blocking the LncRNA MALAT1/miR-224-5p/NLRP3 Axis Inhibits the Hippocampal Inflammatory Response in T2DM With OSA.
c-FLIP, a master anti-apoptotic regulator.
Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity via ROS Pathways.
Carbachol alleviates myocardial injury in septic rats through PI3K/AKT signaling pathway.
Cardioprotective role of GTS-21 by attenuating the TLR4/NF-?B pathway in streptozotocin-induced diabetic cardiomyopathy in rats.
Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins.
CASP-1, -2 and -5 gene polymorphisms and cancer risk: A review and meta-analysis.
Caspase 1, caspase 3, TNF-alpha, p53, and Hif1-alpha gene expression status of the brain tissues and hippocampal neuron loss in short-term dichlorvos exposed rats.
Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion.
Caspase-1 and caspase-8 cleave and inactivate cellular parkin.
Caspase-1 as a radio- and chemo-sensitiser in vitro and in vivo.
Caspase-1 cleaves PPAR? for potentiating the pro-tumor action of TAMs.
Caspase-1 from Human Myeloid-Derived Suppressor Cells Can Promote T Cell-Independent Tumor Proliferation.
Caspase-1 inhibitor reduced the lung injury in a mouse model of pleuropneumonia caused by Actinobacillus pleuropneumoniae.
Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis.
Caspase-1 is a novel target of p63 in tumor suppression.
Caspase-1 regulate AngII-induced cardiomyocyte hypertrophy via upregulation of IL-1?.
Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality.
Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.
Cellulose Nanofiber-Based Hydrogels Embedding 5-FU Promote Pyroptosis Activation in Breast Cancer Cells and Support Human Adipose-Derived Stem Cell Proliferation, Opening New Perspectives for Breast Tissue Engineering.
Cereus sinensis Polysaccharide and Its Immunomodulatory Properties in Human Monocytic Cells.
ch-IAP1, a member of the inhibitor-of-apoptosis protein family, is a mediator of the antiapoptotic activity of the v-Rel oncoprotein.
Changes in the Biomarkers of Oxidative/Nitrosative Stress and Endothelial Dysfunction Are Associated with Cardiovascular Risk in Periodontitis Patients.
Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis.
Chronic Morphine-Induced Changes in Signaling at the A3 Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal.
Chronic sodium salicylate treatment exacerbates brain neurodegeneration in rats infected with Trypanosoma brucei.
Cleavage of caspases-1, -3, -6, -8 and -9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexia.
Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas.
Clinical periodontal status and inflammatory cytokines in primary Sjögren syndrome and rheumatoid arthritis.
Combination therapy of rabies-infected mice with inhibitors of pro-inflammatory host response, antiviral compounds and human rabies immunoglobulin.
Coordinate regulation of IFN consensus sequence-binding protein and caspase-1 in the sensitization of human colon carcinoma cells to Fas-mediated apoptosis by IFN-gamma.
Core 1-derived mucin-type O-glycosylation protects against spontaneous gastritis and gastric cancer.
Cysteine proteinases in tumor cell growth and apoptosis.
Damnacanthal inhibits the NF-?B/RIP-2/caspase-1 signal pathway by inhibiting p56lck tyrosine kinase.
Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis.
Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice.
Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism.
Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein.
Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines.
Dexmedetomidine protects against high mobility group box 1-induced cellular injury by inhibiting pyroptosis.
Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), an anticancer agent, exerts an anti-inflammatory effect in activated human mast cells.
Diacerein Downregulates NLRP3/Caspase-1/IL-1? and IL-6/STAT3 Pathways of Inflammation and Apoptosis in a Rat Model of Cadmium Testicular Toxicity.
Diagnostic value of apoptosis biomarkers in severe sepsis-A pilot study.
Differential effects of colchicine in blood mononuclear cells of patients with Behçet disease in relation to colchicine responsiveness.
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
Direct transcriptional activation of human caspase-1 by tumor suppressor p53.
Diseasome and comorbidities complexities of SARS-CoV-2 infection with common malignant diseases.
Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation.
Dual effects of caspase-1, interleukin-1 beta, tumour necrosis factor-alpha and nerve growth factor receptor in inflammatory myopathies.
Effect of homeopathic treatment on gene expression in Copenhagen rat tumor tissues.
Effects of Ammonium Chloride on Ozone-induced Airway Inflammation: the Role of Slc26a4 in the Lungs of Mice.
Effects of chlorella on activities of protein tyrosine phosphatases, matrix metalloproteinases, caspases, cytokine release, B and T cell proliferations, and phorbol ester receptor binding.
Effects of mild moxibustion on intestinal microbiome and NLRP3 inflammasome in rats with 5-fluorouracil-induced intestinal mucositis.
Effects of Parvovirus B19 In Vitro Infection on Monocytes from Patients with Systemic Sclerosis: Enhanced Inflammatory Pathways by Caspase-1 Activation and Cytokine Production.
Efficacy of fire needle on acute gouty arthritis induced by monosodium urate in rat.
Emerging views of mitophagy in immunity and autoimmune diseases.
Empagliflozin and Liraglutide Differentially Modulate Cardiac Metabolism in Diabetic Cardiomyopathy in Rats.
Expression and prognosis analyses of CASP1 in acute myeloid leukemia.
Expression of caspase activation recruitment and pyrin domain levels of apoptosis-associated speck-like protein complex in the pancreas of rats subjected to experimental pancreatitis: Influence of rutin administration.
Expression of Caspase-1 in breast cancer tissues and its effects on cell proliferation, apoptosis and invasion.
Expression of Inflammasome-Associated Proteins in Human Oropharyngeal Squamous Cell Carcinoma.
Expression of pro-inflammatory cytokine and caspase genes promotes neuronal apoptosis in pontine reticular formation after spinal cord transection.
Expression of tumor necrosis factor-alpha and intercellular adhesion molecule-1 after focal cerebral ischemia in interleukin-1beta converting enzyme deficient mice.
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens.
Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement.
G9A promotes tumor cell growth and invasion by silencing CASP1 in non-small-cell lung cancer cells.
Gamma Radiation Induce Inflammasome Signaling and Pyroptosis in Microvascular Endothelial Cells.
GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells.
Gene expression and protein array studies of folliculin-regulated pathways.
Gene transfer of secreted-type modified interleukin-18 gene to B16F10 melanoma cells suppresses in vivo tumor growth through inhibition of tumor vessel formation.
Genetically modified "obligate" anaerobic Salmonella typhimurium as a therapeutic strategy for neuroblastoma.
Globular adiponectin antagonizes leptin-induced growth of cancer cells by modulating inflammasomes activation: Critical role of HO-1 signaling.
Glutathione and Glutathione Transferase Omega 1 as Key Posttranslational Regulators in Macrophages.
Growth inhibition and apoptosis by an active component of OK-432, a streptococcal agent, via Toll-like receptor 4 in human head and neck cancer cell lines.
Heat shock and HSP70 regulate 5-FU-mediated caspase-1 activation in myeloid-derived suppressor cells and tumor growth in mice.
Hepatocarcinoma Induces a Tumor Necrosis Factor-Dependent Kupffer Cell Death Pathway That Favors Its Proliferation Upon Partial Hepatectomy.
Herkinorin negatively regulates NLRP3 inflammasome to alleviate neuronal ischemic injury through activating Mu opioid receptor and inhibiting the NF-?B pathway.
High glucose inhibits proliferation and differentiation of osteoblast in alveolar bone by inducing pyroptosis.
High levels of expression and nuclear localization of interleukin-1 beta converting enzyme (ICE) and CPP32 in favorable human neuroblastomas.
High mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases.
Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway.
Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-?B Pathway and NLRP3 Inflammasome.
Hydroxytyrosol Acetate Inhibits Vascular Endothelial Cell Pyroptosis via the HDAC11 Signaling Pathway in Atherosclerosis.
Hypouricemic and nephroprotective roles of anthocyanins in hyperuricemic mice.
IL-18 is produced by prostate cancer cells and secreted in response to interferons.
IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation.
Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter.
Immunohistochemical expression of caspase-1 and -9, uncleaved caspase-3 and -6, cleaved caspase-3 and -6 as well as Bcl-2 in benign epithelium and cancer of the prostate.
Impaired apoptotic death signaling in inflammatory lung neutrophils is associated with decreased expression of interleukin-1 beta converting enzyme family proteases (caspases).
In Silico Screening for Anti-Inflammatory Bioactive Molecules from Ayurvedic Decoction, Balaguluchyadi Kashayam.
In vitro Cytokine Responses to Virulent PRRS Virus Strains.
In vivo and in vitro maturation of rabbit oocytes differently affects the gene expression profile, mitochondrial distribution, apoptosis and early embryo development.
Increased expression of NLRP3 inflammasome in placentas from pregnant women with severe preeclampsia.
Inflammasome adaptor ASC suppresses apoptosis of gastric cancer cells by an IL-18 mediated inflammation-independent mechanism.
Inflammasome expression is higher in ovarian tumors than in normal ovary.
Inflammasome Modulation by Chemotherapeutics in Malignant Mesothelioma.
Inflammatory and immune-related factor Caspase 1 contributes to the development of oral lichen planus.
Inflammatory markers in nondiabetic and diabetic rat retinas exposed to ischemia followed by reperfusion.
Inhibiting NLRP3 inflammasome with MCC950 ameliorates perioperative neurocognitive disorders, suppressing neuroinflammation in the hippocampus in aged mice.
Inhibition of ATP-binding cassette transporter downregulates interleukin-1beta-mediated autocrine activation of human dermal fibroblasts.
Inhibition of endotoxin-induced acute lung injury in rats by bone marrow-derived mesenchymal stem cells: Role of Nrf2/HO-1 signal axis in inhibition of NLRP3 activation.
Inhibition of glycolysis alleviates lipopolysaccharide-induced acute lung injury in a mouse model.
Inhibition of IL-32 signaling by bamboo salt decreases pro-inflammatory responses in cellular models of allergic rhinitis.
Inhibitors of TACE and Caspase-1 as anti-inflammatory drugs.
Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl.
Interferon regulatory factor 8 functions as a tumor suppressor in renal cell carcinoma and its promoter methylation is associated with patient poor prognosis.
Interleukin 1 and interleukin 1beta converting enzyme (caspase 1) expression in the human colonic epithelial barrier. Caspase 1 downregulation in colon cancer.
Interleukin 6 receptor inhibitor tocilizumab suppresses cytokine expression, inflammasome activation and phagocytosis in a cell model of sepsis.
Interleukin-1 beta converting enzyme (ICE) is preferentially expressed in neuroblastomas with favourable prognosis.
Interleukin-32 production associated with biliary innate immunity and proinflammatory cytokines contributes to the pathogenesis of cholangitis in biliary atresia.
Intrathecal transplantation of Wharton's jelly mesenchymal stem cells suppresses the NLRP1 inflammasome in the rat model of spinal cord injury.
Involvement of FLIP in 2-methoxyestradiol-induced tumor regression in transgenic adenocarcinoma of mouse prostate model.
Isoquercetin Ameliorates Cerebral Impairment in Focal Ischemia Through Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Effects in Primary Culture of Rat Hippocampal Neurons and Hippocampal CA1 Region of Rats.
Kaiware Daikon (Raphanus sativus L.) extract: a naturally multipotent chemopreventive agent.
Knockdown of TRIM22 Relieves Oxygen-Glucose Deprivation/Reoxygenation-Induced Apoptosis and Inflammation Through Inhibition of NF-?B/NLRP3 Axis.
Liver X receptor ? activation induces pyroptosis of human and murine colon cancer cells.
Long-acting beneficial effect of percutaneously intramyocardially delivered secretome of apoptotic peripheral blood cells on porcine chronic ischemic left ventricular dysfunction.
Loss of caspase-1 and caspase-3 protein expression in human prostate cancer.
Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro.
Magnesium isoglycyrrhizinate blocks fructose-induced hepatic NF-?B/NLRP3 inflammasome activation and lipid metabolism disorder.
Magnesium lithospermate B acts against dextran sodiumsulfate-induced ulcerative colitis by inhibiting activation of the NRLP3/ASC/Caspase-1 pathway.
Maternal obesity induces gut inflammation and impairs gut epithelial barrier function in nonobese diabetic mice.
Medicinal plants and bioactive natural products as inhibitors of NLRP3 inflammasome.
Melanocortin peptides inhibit urate crystal-induced activation of phagocytic cells.
Microglial activation of the NLRP3 inflammasome by the priming signals derived from macrophages infected with mycobacteria.
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Mifepristone-inducible caspase-1 expression in mouse embryonic stem cells eliminates tumor formation but spares differentiated cells in vitro and in vivo.
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation.
miRNA-214 Inhibits Cellular Proliferation and Migration in Glioma Cells Targeting Caspase 1 Involved in Pyroptosis.
Mitochondrial membrane protein mitofusin 2 as a potential therapeutic target for treating free fatty acid-induced hepatic inflammation in dairy cows during early lactation.
Modulation of effector caspase cleavage determines response of breast and lung tumor cell lines to chemotherapy.
Molecular Changes in Sub-lesional Muscle Following Acute Phase of Spinal Cord Injury.
Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease.
Monitoring the Activation of Caspases-1/3/4 for Describing the Pyroptosis Pathways of Cancer Cells.
More than destructive: neutrophil-derived serine proteases in cytokine bioactivity control.
Mulberroside a protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion.
Multiple cytokines are involved in the early events leading to the Alzheimer's disease pathology.
Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors.
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Neuroprotective Effects of Platonin, a Therapeutic Immunomodulating Medicine, on Traumatic Brain Injury in Mice after Controlled Cortical Impact.
Nickel-refining fumes induce NLRP3 activation dependent on mitochondrial damage and ROS production in Beas-2B cells.
NLRC4 suppresses melanoma tumor progression independently of inflammasome activation.
NLRC4, ASC and Caspase-1 Are Inflammasome Components that Are Mediated by P2Y2R Activation in Breast Cancer Cells.
NLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer.
NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide.
NLRP3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study.
NLRP3 Inflammasome: A Possible Link Between Obesity-Associated Low-Grade Chronic Inflammation and Colorectal Cancer Development.
NOD-Like Receptor Protein 3 Inflammasome Priming and Activation in Barrett's Epithelial Cells.
Non-invasive in vivo imaging of caspase-1 activation enables rapid and spatiotemporal detection of acute and chronic inflammatory disorders.
Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study.
O(2)-Vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate protection against D-galactosamine/endotoxin-induced hepatotoxicity in mice: genomic analysis using microarrays.
Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis.
Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators.
Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis.
Overexpression of caspase-1 in pancreatic disorders: implications for a function besides apoptosis.
Overexpression of IL-1ra gene up-regulates interleukin-1beta converting enzyme (ICE) gene expression: possible mechanism underlying IL-1beta-resistance of cancer cells.
Oxidative stress does not contribute to the release of proinflammatory cytokines through activating the Nod-like receptor protein 3 inflammasome in patients with obstructive sleep apnoea.
p38 mitogen activated protein kinase mediates both death signaling and functional depression in the heart.
Pathophysiology of NSAID-Associated Intestinal Lesions in the Rat: Luminal Bacteria and Mucosal Inflammation as Targets for Prevention.
Pharmacogenomics of cantharidin in tumor cells.
Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell.
Poxviral modifiers of cytokine responses to infection.
Prognostic impact of {triangleup}TAp73 isoform levels and their target genes in colon cancer patients.
Prognostic Relevance of Expression of EMP1, CASP1, and NLRP3 Genes in Pediatric B-Lineage Acute Lymphoblastic Leukemia.
Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis.
Protective effect of leaf essential oil from Cinnamomum osmophloeum Kanehira on endotoxin-induced intestinal injury in mice associated with suppressed local expression of molecules in the signaling pathways of TLR4 and NLRP3.
Protective effects of morin against depressive-like behavior prompted by chronic unpredictable mild stress in rats: Possible role of inflammasome-related pathways.
Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors.
Protein network exploration prioritizes targets for modulating neuroinflammation in Parkinson's disease.
Provocative decompression causes diffuse vascular injury in mice mediated by microparticles containing interleukin-1?.
Pyoderma gangrenosum-a novel approach?
Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma.
Qianliexin capsule exerts anti-inflammatory activity in chronic non-bacterial prostatitis and benign prostatic hyperplasia via NF-?B and inflammasome.
Reciprocal negative regulation between the tumor suppressor protein p53 and B cell CLL/lymphoma 6 (BCL6) via control of caspase-1 expression.
Regression of schwannomas induced by adeno-associated virus-mediated delivery of caspase-1.
Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis.
Regulatory effects of apoptosis-associated speck-like protein on cytokines in the P388D1 macrophage-like cell line.
Repeated Morphine Prolongs Postoperative Pain in Male Rats.
Restoration of transforming growth factor beta signaling pathway in human prostate cancer cells suppresses tumorigenicity via induction of caspase-1-mediated apoptosis.
Resveratrol inhibits high-glucose-induced inflammatory "metabolic memory" in human retinal vascular endothelial cells through SIRT1-dependent signaling.
Retroviral delivery and tetracycline-dependent expression of IL-1beta-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells.
Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases.
Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin.
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Rosiglitazone ameliorates radiation-induced intestinal inflammation in rats by inhibiting NLRP3 inflammasome and TNF-? production.
Rutin attenuates neuroinflammation in spinal cord injury rats.
S-allyl cysteine, an active ingredient of garlic, attenuates acute liver dysfunction induced by lipopolysaccharide/ d-galactosamine in mouse: Underlying mechanisms.
Saliva levels of caspase-1, TNF-?, and IFN-? in primary Sjögren's syndrome: oral mucosal abnormalities revisited
Sequence and expression variations in 23 genes involved in mitochondrial and non-mitochondrial apoptotic pathways and risk of oral leukoplakia and cancer.
Serum caspase-1 levels in metastatic melanoma patients: relationship with tumour burden and non-response to biochemotherapy.
Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression.
Sialylated human milk oligosaccharides prevent intestinal inflammation by inhibiting toll like receptor 4/NLRP3 inflammasome pathway in necrotizing enterocolitis rats.
Silencing of long non-coding RNA MEG3 alleviates lipopolysaccharide-induced acute lung injury by acting as a molecular sponge of microRNA-7b to modulate NLRP3.
Silencing of the caspase-1 gene occurs in murine and human renal cancer cells and causes solid tumor growth in vivo.
Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation.
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease.
SP1-induced ZFAS1 aggravates sepsis-induced cardiac dysfunction via miR-590-3p/NLRP3-mediated autophagy and pyroptosis.
Stress-induced cartilage degradation does not depend on NLRP3 inflammasome in osteoarthritis.
Stress-related gene expression in mice treated with inorganic arsenicals.
Suppressive Effect of Huzhentongfeng on Experimental Gouty Arthritis: An In Vivo and In Vitro Study.
Targeting procaspase-3 with WF-208, a novel PAC-1 derivative, causes selective cancer cell apoptosis.
Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy.
TCR-dependent sensitization of human ?? T cells to non-myeloid IL-18 in cytomegalovirus and tumor stress surveillance.
Thalidomide Improves the Intestinal Mucosal Injury and Suppresses Mesenteric Angiogenesis and Vasodilatation by Down-Regulating Inflammasomes-Related Cascades in Cirrhotic Rats.
The 5352 A allele of the pro-inflammatory caspase-1 gene predicts late-acquired stent malapposition in STEMI patients treated with sirolimus stents.
The Caspase-1/IL-18 Axis of the Inflammasome in Tumor Cells: A Modulator of the Th1/Tc1 Response of Tumor-Infiltrating T Lymphocytes in Colorectal Cancer.
The constitutive protease release by primary human acute myeloid leukemia cells.
The effects of polymorphisms in 7 candidate genes on resistance to Salmonella Enteritidis in native chickens.
The expression of apoptosis-related proteins and the apoptotic rate in glial tumors of the brain.
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
The NLRP3 inflammasome: a therapeutic target for inflammation-associated cancers.
The novel interplay between CD44 standard isoform and the caspase-1/IL1B pathway to induce hepatocellular carcinoma progression.
The possible ameliorative effect of simvastatin versus sulfasalazine on acetic acid induced ulcerative colitis in adult rats.
The role of cellular flice inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer.
The role of exosomal miR-375-3p: A potential suppressor in bladder cancer via the Wnt/?-catenin pathway.
Thioredoxin-Interacting Protein: a Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice.
TLR2 and Nod2 Mediate Resistance or Susceptibility to Fatal Intracellular Ehrlichia Infection in Murine Models of Ehrlichiosis.
Tofacitinib inhibits granulocyte-macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils.
Toll like receptor 4 and hepatocellular carcinoma; A systematic review.
Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445.
Tumor necrosis factor and lymphotoxin: protection against oxidative stress through induction of MnSOD.
Tumor necrosis factor-alpha-induced apoptosis in olfactory epithelium in vitro: possible roles of caspase 1 (ICE), caspase 2 (ICH-1), and caspase 3 (CPP32).
Tumor necrosis factor-alpha-induced caspase-1 gene expression. Role of p73.
Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer.
USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3.
Virus-Like Particle-Drug Conjugates Induce Protective, Long-lasting Adaptive Antitumor Immunity in the Absence of Specifically Targeted Tumor Antigens.
[C1q/tumor necrosis factor related protein 6 (CTRP6) is involved in gentamicin-induced acute kidney injury in rats].
[Impact of preoperative drug therapy on the expression of apoptosis markers in colorectal liver metastases].
[NLRP3 inflammasome induces pyroptosis in lung tissues of radiation-induced lung injury in mice].
Nephritis
Caspase-1 is required for maintenance of marginal zone B cells in pristane-induced lupus.
Nephrolithiasis
Vitexin exerts protective effects against calcium oxalate crystal-induced kidney pyroptosis in vivo and in vitro.
Nervous System Diseases
Serum Amyloid A-Mediated Inflammasome Activation of Microglial Cells in Cerebral Ischemia.
[Pyroptosis and stroke].
Netherton Syndrome
Caspase-1 activity of stratum corneum and serum interleukin-18 level are increased in patients with Netherton syndrome.
Neuralgia
Involvement of the spinal NALP1 inflammasome in neuropathic pain and aspirin-triggered-15-epi-lipoxin A4 induced analgesia.
miR-223 Inhibits the Polarization and Recruitment of Macrophages via NLRP3/IL-1? Pathway to Meliorate Neuropathic Pain.
Neurilemmoma
Delivery of Therapeutic Proteins via Extracellular Vesicles: Review and Potential Treatments for Parkinson's Disease, Glioma, and Schwannoma.
Regression of schwannomas induced by adeno-associated virus-mediated delivery of caspase-1.
Neuroblastoma
Activation of caspase-3 alone is insufficient for apoptotic morphological changes in human neuroblastoma cells.
Caspase-1 as a radio- and chemo-sensitiser in vitro and in vivo.
Caspase-1 inhibitors abolish deleterious enhancement of COX-2 expression induced by HIV-1 gp120 in human neuroblastoma cells.
Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.
Cell death in amyotrophic lateral sclerosis: interplay between neuronal and glial cells.
Characterization of CPP32-like protease activity following apoptotic challenge in SH-SY5Y neuroblastoma cells.
Ginsenoside Rh2 induces apoptosis via activation of caspase-1 and -3 and up-regulation of Bax in human neuroblastoma.
High levels of expression and nuclear localization of interleukin-1 beta converting enzyme (ICE) and CPP32 in favorable human neuroblastomas.
IL-1beta and ICE mRNA are not altered upon beta-amyloid(25-35) induced neurotoxicity in human neuroblastoma cells.
Interleukin-1 beta converting enzyme (ICE) is preferentially expressed in neuroblastomas with favourable prognosis.
Pyroptosis induced by enterovirus A71 infection in cultured human neuroblastoma cells.
TNF-? May Mediate Inflammasome Activation in the Absence of Bacterial Infection in More than One Way.
Neurodegenerative Diseases
Caspase-1 inhibition attenuates activation of BV2 microglia induced by LPS-treated RAW264.7 macrophages.
Effects of caspase-1 knockout on chronic neural recording quality and longevity: insight into cellular and molecular mechanisms of the reactive tissue response.
Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration.
Inhibition of Caspase-1 Ameliorates Ischemia-Associated Blood-Brain Barrier Dysfunction and Integrity by Suppressing Pyroptosis Activation.
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease.
Neuroinflammatory Diseases
A novel nutritional mixture, MBN, prevents memory impairment via inhibiting NLRP3 inflammasome formation in 5xFAD transgenic mice.
A novel role of interleukin-1-converting enzyme in cytokine-mediated inducible nitric oxide synthase gene expression: Implications for neuroinflammatory diseases.
A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer's and Parkinson's Disease.
Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo.
Acceleration of NLRP3 inflammasome by chronic cerebral hypoperfusion in Alzheimer's disease model mouse.
Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors.
Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats.
An Engineered sgsh Mutant Zebrafish Recapitulates Molecular and Behavioural Pathobiology of Sanfilippo Syndrome A/MPS IIIA.
Atorvastatin ameliorates early brain injury after subarachnoid hemorrhage via inhibition of pyroptosis and neuroinflammation.
C-terminal truncation exacerbates the aggregation and cytotoxicity of ?-Synuclein: A vicious cycle in Parkinson's disease.
Caspase-1 Deficiency Alleviates Dopaminergic Neuronal Death via Inhibiting Caspase-7/AIF Pathway in MPTP/p Mouse Model of Parkinson's Disease.
Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer's disease mouse model.
Chrysomycin A Attenuates Neuroinflammation by Down-Regulating NLRP3/Cleaved Caspase-1 Signaling Pathway in LPS-Stimulated Mice and BV2 Cells.
Converging actions of alcohol on liver and brain immune signaling.
EK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury.
Ellagic acid ameliorates neuroinflammation and demyelination in experimental autoimmune encephalomyelitis: Involvement of NLRP3 and pyroptosis.
Exosome-mediated inflammasome signaling after central nervous system injury.
High Ca(2+) Influx During Traumatic Brain Injury Leads to Caspase-1-Dependent Neuroinflammation and Cell Death.
HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation.
Inflammasome Caspase-1 Activity is Elevated in Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage and Predicts Functional Outcome.
Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition.
Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease.
Interaction between hyperphosphorylated tau and pyroptosis in forskolin and streptozotocin induced AD models.
Intranasal Delivery of a Caspase-1 Inhibitor in the Treatment of Global Cerebral Ischemia.
Involvement of NLRC4 inflammasome through caspase-1 and IL-1? augments neuroinflammation and contributes to memory impairment in an experimental model of Alzheimer's like disease.
Isovitexin modulates autophagy in Alzheimer's disease via miR-107 signalling.
Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases.
Melatonin improves quality and longevity of chronic neural recording.
miR-223 Inhibits the Polarization and Recruitment of Macrophages via NLRP3/IL-1? Pathway to Meliorate Neuropathic Pain.
Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation.
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma.
NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL-? in sclerotic hippocampi.
NLRP3 inflammasome pathway is involved in olfactory bulb pathological alteration induced by MPTP.
Non-invasive in vivo imaging of caspase-1 activation enables rapid and spatiotemporal detection of acute and chronic inflammatory disorders.
P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH.
Protein network exploration prioritizes targets for modulating neuroinflammation in Parkinson's disease.
Pterostilbene inhibits amyloid-?-induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase-1 inflammasome pathway.
Salvianolic acid B protects against MPP+-induced neuronal injury via repressing oxidative stress and restoring mitochondrial function.
Sinomenine Alleviates Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis through Inhibiting NLRP3 Inflammasome.
The Mechanisms of Cerebral Vascular Dysfunction and Neuroinflammation by MMP-Mediated Degradation of VEGFR-2 in Alcohol Ingestion.
The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease.
The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia.
The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain Injury.
The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability.
Transient receptor potential melastatin 2 contributes to neuroinflammation and negatively regulates cognitive outcomes in a pilocarpine-induced mouse model of epilepsy.
VX-765 reduces neuroinflammation after spinal cord injury in mice.
Neuronal Ceroid-Lipofuscinoses
Caspase 1 activity influences juvenile Batten disease (CLN3) pathogenesis.
Non-alcoholic Fatty Liver Disease
Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3.
Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation.
Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases.
Expression of NALPs in adipose and the fibrotic progression of non-alcoholic fatty liver disease in obese subjects.
Hepatic nucleotide binding oligomerization domain-like receptors pyrin domain-containing 3 inflammasomes are associated with the histologic severity of non-alcoholic fatty liver disease.
Inhibition of hepatic interleukin-18 production by rosiglitazone in a rat model of nonalcoholic fatty liver disease.
Mice Deficient in the IL-1? Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.
NLRP3 inflammasome activation is required for fibrosis development in NAFLD.
Sini powder ameliorates the inflammatory response in rats with stress-induced non-alcoholic fatty liver disease by inhibiting the nuclear factor kappa-B / pyrin domain-containing protein 3 pathway.
[Effects of GPR81 agonist on insulin resistance in rats with nonalcoholic fatty liver disease].
non-specific serine/threonine protein kinase deficiency
LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.
Obesity
Cardiovascular diseases, NLRP3 inflammasome, and western dietary patterns.
Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis.
Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity.
Caspases and inflammasomes in metabolic inflammation.
Inflammasome is a central player in the induction of obesity and insulin resistance.
Obesity development in caspase-1-deficient mice.
Probiotics modify body weight together with anxiety states via pro-inflammatory factors in HFD-treated Syrian golden hamster.
Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases.
The Impact of Acute Ingestion of a Ketone Monoester Drink on LPS-Stimulated NLRP3 Activation in Humans with Obesity.
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity.
Obstetric Labor, Premature
A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis.
Evidence of the involvement of caspase-1 under physiologic and pathologic cellular stress during human pregnancy: a link between the inflammasome and parturition.
Gasdermin D: Evidence of pyroptosis in spontaneous preterm labor with sterile intra-amniotic inflammation or intra-amniotic infection.
Optic Atrophy, Autosomal Dominant
Recombinant High-Mobility Group Box 1 (rHMGB1) Promotes NRF2-Independent Mitochondrial Fusion through CXCR4/PSMB5-Mediated Drp1 Degradation in Endothelial Cells.
Osteoarthritis
Caspase-1 level in synovial fluid is high in patients with spondyloarthropathy but not in patients with gout.
Expression and function of the NALP3 inflammasome in rheumatoid synovium.
Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy.
Novel irreversible caspase-1 inhibitor attenuates the maturation of intracellular interleukin-1beta.
Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis.
The in situ up-regulation of chondrocyte interleukin-1-converting enzyme and interleukin-18 levels in experimental osteoarthritis is mediated by nitric oxide.
The NLRP3/Caspase-1/Interleukin-1? Axis Is Active in Human Lumbar Cartilaginous Endplate Degeneration.
Osteoarthritis, Knee
Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy.
miR-107 affects cartilage matrix degradation in the pathogenesis of knee osteoarthritis by regulating caspase-1.
Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis.
Osteolysis
Metal-induced delayed type hypersensitivity responses potentiate particle induced osteolysis in a sex and age dependent manner.
Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation.
Osteomyelitis
Alendronate augments interleukin-1beta release from macrophages infected with periodontal pathogenic bacteria through activation of caspase-1.
Dietary modulation of the microbiome affects autoinflammatory disease.
New discoveries in CRMO: IL-1?, the neutrophil, and the microbiome implicated in disease pathogenesis in Pstpip2-deficient mice.
Osteonecrosis
Bisphosphonate Induces Osteonecrosis of the Jaw in Diabetic Mice via NLRP3/Caspase-1-Dependent IL-1? Mechanism.
Osteoporosis
NLRP3 inflammasome activation in mesenchymal stem cells inhibits osteogenic differentiation and enhances adipogenic differentiation.
Osteosarcoma
Berberine affects osteosarcoma via downregulating the caspase-1/IL-1? signaling axis.
c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.
Caspase-1 as a radio- and chemo-sensitiser in vitro and in vivo.
Identification of characteristic gene modules of osteosarcoma using bioinformatics analysis indicates the possible molecular pathogenesis.
Serum concentrations of APO-1/Fas and interleukin-1beta-converting enzyme in osteosarcoma correlate with response to chemotherapy.
Otitis Media
Activation of NLRP3 inflammasome in human middle ear cholesteatoma and chronic otitis media.
NLRP3 inflammasome expression in lipopolysaccharide-induced otitis media.
Otitis Media with Effusion
NLRP3 inflammasome expression in lipopolysaccharide-induced otitis media.
Role of Macrophage Migration Inhibitory Factor in NLRP3 Inflammasome Expression in Otitis Media.
Ototoxicity
Protective mechanism of Korean Red Ginseng in cisplatin-induced ototoxicity through attenuation of nuclear factor-?B and caspase-1 activation.
Rosmarinic acid, active component of Dansam-Eum attenuates ototoxicity of cochlear hair cells through blockage of caspase-1 activity.
Ovarian Neoplasms
Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein.
Interferon regulatory factor-1 mediates interferon-gamma-induced apoptosis in ovarian carcinoma cells.
Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro.
The expression profile of apoptosis-related genes in the chicken as a human epithelial ovarian cancer model.
The role of c-FLIP(L) in ovarian cancer: Chaperoning tumor cells from immunosurveillance and increasing their invasive potential.
[The influences of interleukin-1 beta converting enzyme expression on the biologic characteristics of ovarian cancer cells]
Overweight
Caspase-11-mediated enteric neuronal pyroptosis underlies Western diet-induced colonic dysmotility.
Pancreatic Neoplasms
Interferon gamma inhibits growth of human pancreatic carcinoma cells via caspase-1 dependent induction of apoptosis.
Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis.
Overexpression of caspase-1 in pancreatic disorders: implications for a function besides apoptosis.
Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells.
The effects of NLRP3 inflammasome inhibition by MCC950 on LPS-induced pancreatic adenocarcinoma inflammation.
Pancreatitis
Caspase-1 inhibition alleviates acute renal injury in rats with severe acute pancreatitis.
Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis.
Clinical relevance of caspase-1 activated cytokines in acute pancreatitis: high correlation of serum interleukin-18 with pancreatic necrosis and systemic complications.
Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition.
Interleukin-18: a pro-inflammatory cytokine that plays an important role in acute pancreatitis.
Overexpression of caspase-1 (interleukin-1beta converting enzyme) in chronic pancreatitis and its participation in apoptosis and proliferation.
Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis.
Overexpression of caspase-1 in pancreatic disorders: implications for a function besides apoptosis.
Ritonavir and disulfiram may be synergistic in lowering active interleukin-18 levels in acute pancreatitis, and thereby hasten recovery.
Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE).
Sterile inflammatory response in acute pancreatitis.
Therapeutic effects of caspase-1 inhibitors on acute lung injury in experimental severe acute pancreatitis.
TLR9 and the NLRP3 Inflammasome Link Acinar Cell Death With Inflammation in Acute Pancreatitis.
Pancreatitis, Acute Necrotizing
Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis.
Clinical relevance of caspase-1 activated cytokines in acute pancreatitis: high correlation of serum interleukin-18 with pancreatic necrosis and systemic complications.
Pancreatitis, Chronic
Overexpression of caspase-1 (interleukin-1beta converting enzyme) in chronic pancreatitis and its participation in apoptosis and proliferation.
Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis.
Overexpression of caspase-1 in pancreatic disorders: implications for a function besides apoptosis.
Papilloma
Expression of Inflammasome-Associated Proteins in Human Oropharyngeal Squamous Cell Carcinoma.
Inflammasome activation is critical to the protective immune response during chemically induced squamous cell carcinoma.
Paramyxoviridae Infections
Emerging views of mitophagy in immunity and autoimmune diseases.
Human parainfluenza virus type 2 V protein inhibits caspase-1.
Parasitemia
Elevated plasma abscisic acid is associated with asymptomatic falciparum malaria and with IgG-/caspase-1-dependent immunity in Plasmodium yoelii-infected mice.
Paratyphoid Fever
Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever.
Parkinson Disease
Caspase-1 Deficiency Alleviates Dopaminergic Neuronal Death via Inhibiting Caspase-7/AIF Pathway in MPTP/p Mouse Model of Parkinson's Disease.
Cdk5-Dependent Activation of Neuronal Inflammasomes in Parkinson's Disease.
Delivery of Therapeutic Proteins via Extracellular Vesicles: Review and Potential Treatments for Parkinson's Disease, Glioma, and Schwannoma.
Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo.
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease.
Parkinsonian Disorders
Emerging views of mitophagy in immunity and autoimmune diseases.
Isoflavone Attenuates the Caspase-1 and Caspase-3 Level in Cell Model of Parkinsonism.
Pericarditis
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.
Periodontal Diseases
GWAS for Interleukin-1? levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation.
Relevance of Caspase-1 and Nlrp3 Inflammasome on Inflammatory Bone Resorption in A Murine Model of Periodontitis.
Salivary Levels of NLRP3 Inflammasome-Related Proteins as Potential Biomarkers of Periodontal Clinical Status.
Upregulation of proteins of the NLRP3 inflammasome in patients with periodontitis and uncontrolled type 2 diabetes.
Periodontitis
Cranberry Proanthocyanidins Neutralize the Effects of Aggregatibacter actinomycetemcomitans Leukotoxin.
NLRP6 Induces Pyroptosis by Activation of Caspase-1 in Gingival Fibroblasts.
Relevance of Caspase-1 and Nlrp3 Inflammasome on Inflammatory Bone Resorption in A Murine Model of Periodontitis.
Role of inflammasomes in the pathogenesis of periodontal disease and therapeutics.
Peripheral Nerve Injuries
Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes.
Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats.
Peritonitis
1'-Acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression.
A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction.
Apoptosis inhibitor of macrophage (AIM) contributes to IL-10-induced anti-inflammatory response through inhibition of inflammasome activation.
BECN2 (beclin 2) Negatively Regulates Inflammasome Sensors Through ATG9A-Dependent but ATG16L1- and LC3-Independent Non-Canonical Autophagy.
Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome.
Mechanistic insight into the attenuation of gouty inflammation by Taiwanese green propolis via inhibition of the NLRP3 inflammasome.
Molecule 16673-34-0: a new tool in our arsenal against inflammation.
Repositioning of the ?-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome.
Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Inflammasome.
The ketone metabolite ?-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
The local inflammatory responses to infection of the peritoneal cavity in humans: their regulation by cytokines, macrophages, and other leukocytes.
TLR4 and NLRP3 Caspase 1- IL-1?- Axis are not Involved in Colon Ascendens Stent Peritonitis (Casp)-Associated Heart Disease.
Toll-Like Receptor 4 and NLRP3 Caspase 1- Interleukin-1?-Axis are Not Involved in Colon Ascendens Stent Peritonitis-Associated Heart Disease.
Persistent Infection
Cardiac apoptosis in severe relapsing fever borreliosis.
Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection.
Pleuropneumonia
Caspase-1 inhibitor reduced the lung injury in a mouse model of pleuropneumonia caused by Actinobacillus pleuropneumoniae.
Pneumococcal Infections
Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.
NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages.
Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization.
Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia.
Pneumonia
4,4'-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor.
ASC and NLRP3 impair host defense during lethal pneumonia caused by serotype 3 Streptococcus pneumoniae in mice.
Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin.
Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation.
Caspase-1 Activation Protects Lung Endothelial Barrier Function During Infection-induced Stress.
Effects of gestational exposure to perfluorooctane sulfonate on the lung development of offspring rats.
Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies.
Interleukin-1 Receptor and Caspase-1 are Required for the Th17 Response in NO2-Promoted Allergic Airway Disease.
NLRP3/Caspase-1-Independent IL-1{beta} Production Mediates Diesel Exhaust Particle-Induced Pulmonary Inflammation.
Outer membrane protein A inhibits the degradation of caspase-1 to regulate NLRP3 inflammasome activation and exacerbate the Acinetobacter baumannii pulmonary inflammation.
PAD2 Mediates Caspase-1 Associated Lethality in Pseudomonas Aeruginosa Pneumonia Induced Sepsis.
Polyvalent Bacterial Lysate Protects Against Pneumonia Independently of Neutrophils, IL-17A or Caspase-1 Activation.
Role of IL-1{alpha} and the Nlrp3/caspase-1/IL-1{beta} axis in cigarette smoke-induced pulmonary inflammation and COPD.
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.
The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation.
[TLR-4 involvement in pyroptosis of mice with pulmonary inflammation infected by Actinobacillus pleuropneumoniae].
Pneumonia, Pneumococcal
ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism.
Polycystic Ovary Syndrome
Serum Caspase-1 levels in women with polycystic ovary syndrome.
Porcine Reproductive and Respiratory Syndrome
Signaling in innate immunity and inflammation.
Post-Lyme Disease Syndrome
Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism.
Postpartum Hemorrhage
Identification and validation of uterine stimulant methylergometrine as a potential inhibitor of caspase-1 activation.
Pre-Eclampsia
Lipoxin A4 suppresses angiotensin II type 1 receptor autoantibody in preeclampsia via modulating caspase-1.
[C1q and tumor necrosis factor related protein 4 (CTRP4) suppresses caspase-1/IL-1? inflammatory pathway in trophoblasts of rat models with preeclampsia].
[Caspase 1, superoxide dismutase (D-mutase) and calretinin expression in the placenta and in the basal decidua in preeclampsia].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Inflammasome-mediated glucocorticoid resistance: The receptor rheostat.
Prognostic Relevance of Expression of EMP1, CASP1, and NLRP3 Genes in Pediatric B-Lineage Acute Lymphoblastic Leukemia.
Premature Birth
A clear and present danger: inflammasomes DAMPing down disorders of pregnancy.
Inflammation-Induced Intra-Amniotic inflammation induces preterm birth by Activating the NLRP3 inflammasome.
Prion Diseases
The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia.
Prolactinoma
Microglial NLRP3 inflammasome activation-mediated inflammation promotes prolactinoma development.
Prostatic Hyperplasia
[Expression and significance of caspase-1 in benign hyperplastic prostate tissues]
Prostatic Neoplasms
Activation of TGF-beta signalling in human prostate cancer cells suppresses tumorigenicity via deregulation of cell cycle progression and induction of caspase-1 mediated apoptosis: significance in prostate tumorigenesis.
Bcl-2 antagonizes the combined apoptotic effect of transforming growth factor-beta and dihydrotestosterone in prostate cancer cells.
Caspase-1 enhances the apoptotic response of prostate cancer cells to ionizing radiation.
Correction: Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation.
Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation.
Dihydrotestosterone enhances transforming growth factor-beta-induced apoptosis in hormone-sensitive prostate cancer cells.
IL-18 is produced by prostate cancer cells and secreted in response to interferons.
Immunohistochemical expression of caspase-1 and -9, uncleaved caspase-3 and -6, cleaved caspase-3 and -6 as well as Bcl-2 in benign epithelium and cancer of the prostate.
Immunohistochemical study of Fas, Fas ligand and interleukin-1 beta converting enzyme expression in human prostatic cancer.
Loss of caspase-1 and caspase-3 protein expression in human prostate cancer.
Protein profiling of isolated leukocytes, myofibroblasts, epithelial, Basal, and endothelial cells from normal, hyperplastic, cancerous, and inflammatory human prostate tissues.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation.
Proteinuria
Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation.
The changes in pyroptosis-related inflammatory factors in the peripheral blood of patients with Henoch-Schonlein purpura.
Pseudomonas Infections
cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection.
Caspase-1 cleavage of the TLR adaptor TRIF inhibits autophagy and ?-interferon production during Pseudomonas aeruginosa infection.
Caspase-1 induces apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC)-mediated necrosis independently of its catalytic activity.
Cutting edge: IL-1? processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1.
Psoriasis
Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin in?ammation.
Caspase 1/11 deficiency or pharmacological inhibition mitigates psoriasis-like phenotype in mice.
EFLA 945 restricts AIM2 inflammasome activation by preventing DNA entry for psoriasis treatment.
Expression of NLPR3 in Psoriasis Is Associated with Enhancement of Interleukin-1? and Caspase-1.
Key component of inflammasome, NLRC4, was identified in the lesional epidermis of psoriatic patients.
Methotrexate regulates Th-1 response by suppressing caspase-1 and cytokines in psoriasis patients.
Multifactorial Activation of NLRP3 Inflammasome: Relevance for a Precision Approach to Atherosclerotic Cardiovascular Risk and Disease.
The activity of caspase-1 is increased in lesional psoriatic epidermis.
The Increased Expression of Matrix Metalloproteinase-9 Messenger RNA in the Non-lesional Skin of Patients with Large Plaque Psoriasis Vulgaris.
Pterygium
Pyroptosis in pterygium pathogenesis.
Pulmonary Disease, Chronic Obstructive
Dual function inhibitors of relevance to chronic obstructive pulmonary disease.
P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke.
Role of P2X7 Receptors in Release of IL-1?: A Possible Mediator of Pulmonary Inflammation.
The Anti-inflammatory Effect of Alpha-1 Antitrypsin in Rhinovirus-infected Human Airway Epithelial Cells.
The inflammasome pathway in stable COPD and acute exacerbations.
The NLRP3 Inflammasome Regulates Bronchial Epithelial Cell Injury and Pro-apoptosis After Exposure to Biomass Fuel Smoke.
Pulmonary Edema
Caspase-1 Activation Protects Lung Endothelial Barrier Function During Infection-induced Stress.
Caspase-1 Inhibitor Prevents Neurogenic Pulmonary Edema After Subarachnoid Hemorrhage in Mice.
Pulmonary Fibrosis
Innate immunity and inflammation in systemic sclerosis.
[Expression and significance of NLRP3/IL-1?/TGF-?(1) signal axis in rat model of silicosis pulmonary fibrosis].
Pulpitis
Activation of the NLRP3/caspase-1 inflammasome in human dental pulp tissue and human dental pulp fibroblasts.
Rabies
Correlation of inducible nitric oxide synthase (iNOS) inhibition with TNF-?, caspase-1, FasL and TLR-3 in pathogenesis of rabies in mouse model.
Inhibition of caspase-1 prolongs survival of mice infected with rabies virus.
receptor protein serine/threonine kinase deficiency
Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-?B and MAPK signaling.
Relapsing Fever
Cardiac apoptosis in severe relapsing fever borreliosis.
Renal Insufficiency, Chronic
Caspase-1 Plays a Critical Role in Accelerating Chronic Kidney Disease-Promoted Neointimal Hyperplasia in the Carotid Artery.
NLRP3 inflammasome activation in dialyzed chronic kidney disease patients.
Renal involvement in autoinflammatory diseases and inflammasome-mediated chronic kidney damage.
Reperfusion Injury
Activated caspase-1 is not a central mediator of inflammation in the course of ischemia-reperfusion.
Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury.
An inflammasome-independent role for epithelial-expressed nlrp3 in renal ischemia-reperfusion injury.
Apoptotic retinal neuronal death by ischemia-reperfusion is executed by two distinct caspase family proteases.
BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia.
Caspase-1-independent maturation of IL-1? in Ischemic Brain Injury: is there a role for gelatinases?
Decreased retinal neuronal cell death in caspase-1 knockout mice.
Differential effects of caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney.
Dunye Guanxinning Improves Acute Myocardial Ischemia-Reperfusion Injury by Inhibiting Neutrophil Infiltration and Caspase-1 Activity.
Early activation of caspase-1 after retinal ischemia and reperfusion injury in mice.
Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice.
Ischemia reperfusion injury induces pyroptosis and mediates injury in steatotic liver thorough Caspase 1 activation.
Ischemia-reperfusion induces renal tubule pyroptosis via the CHOP-caspase-11 pathway.
The Role of Pyroptosis in Ischemic and Reperfusion Injury of the Heart.
Transient Receptor Potential Melastatin 2 Negatively Regulates LPS-ATP-Induced Caspase-1-Dependent Pyroptosis of Bone Marrow-Derived Macrophage by Modulating ROS Production.
[Retinal neuronal cell death: molecular mechanism and neuroprotection]
Respiratory Distress Syndrome
Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection.
Respiratory Syncytial Virus Infections
Caspase-1 independent viral clearance and adaptive immunity against mucosal respiratory syncytial virus infection.
Respiratory syncytial virus infection of human alveolar epithelial cells enhances interferon regulatory factor 1 and interleukin-1beta-converting enzyme gene expression but does not cause apoptosis.
Retinal Degeneration
Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa.
Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration.
Expression of a CARD Slows the Retinal Degeneration of a Geographic Atrophy Mouse Model.
Gene expression in the mouse retina: the effect of damaging light.
Retinal Diseases
Atypical cytomegalovirus retinal disease in pyroptosis-deficient mice with murine acquired immunodeficiency syndrome.
Retinitis Pigmentosa
Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa.
Retinoblastoma
Functions of ceramide in coordinating cellular responses to stress.
Involvement of interleukin-1beta-converting enzyme in apoptosis of irradiated retinoblastomas.
Rheumatic Diseases
Activation of caspase-1 is mediated by stimulation of interferon genes and NLR family pyrin domain containing 3 in monocytes of active systemic lupus erythematosus.
[Caspase-1 regulates autoinflammation in rheumatic diseases].
Rhinitis, Allergic
AIM2 inflammasome activation may mediate high mobility group box 1 release in murine allergic rhinitis.
Bamboo salt reduces allergic responses by modulating the caspase-1 activation in an OVA-induced allergic rhinitis mouse model.
Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro System.
Inhibition of IL-32 and TSLP production through the attenuation of caspase-1 activation in an animal model of allergic rhinitis by Naju Jjok (Polygonum tinctorium).
ribonuclease iii deficiency
DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis.
Salmonella Infections
Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms.
Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone.
Caspase-1 Activation Protects Lung Endothelial Barrier Function During Infection-induced Stress.
Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.
Caspase-7 mediates caspase-1-induced apoptosis independently of Bid.
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages.
Role of inflammasomes in salmonella infection.
Salmonella and Caspase-1: A complex Interplay of Detection and Evasion.
Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1? production.
Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkc?.
Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes.
Sarcoma 180
Hepatocyte growth factor/scatter factor activates the apoptosis signaling pathway by increasing caspase-3 activity in sarcoma 180 cells.
Schnitzler Syndrome
Free circulating interleukin-18 is increased in Schnitzler syndrome: a new autoinflammatory disease?
Scleroderma, Systemic
Effects of Parvovirus B19 In Vitro Infection on Monocytes from Patients with Systemic Sclerosis: Enhanced Inflammatory Pathways by Caspase-1 Activation and Cytokine Production.
Evaluation of caspase 1 and sFas serum levels in patients with systemic sclerosis: correlation with lung dysfunction, joint and bone involvement.
The inflammasome activating caspase-1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis.
The Role of the NLRP3 Inflammasome in Fibrosis.
Scrapie
Neuroinvasion by scrapie following inoculation via the skin is independent of migratory Langerhans cells.
Role of interleukin-1 in prion disease-associated astrocyte activation.
Seizures
Chaihu-Longgu-Muli Decoction exerts an antiepileptic effect in rats by improving pyroptosis in hippocampal neurons.
Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy.
Interleukin-1? Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice.
Subicular Caspase-1 Contributes to Pharmacoresistance in Temporal Lobe Epilepsy.
[Expression and significance of caspase-1, IL-18 and IL-1beta in the hippocampus of the developing recurrent seizures rats]
[Role of caspase-1 and cytokines activated by caspase-1 in brain injury of the developing rats following recurrent seizures.]
Seizures, Febrile
Febrile seizures: characterization of double-stranded RNA-induced gene expression.
Structure-based discovery of CZL80, a caspase-1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility.
Sepsis
Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism.
Artemisinin protects mice against burn sepsis through inhibiting NLRP3 inflammasome activation.
Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.
C10X polymorphism in the CARD8 gene is associated with bacteraemia.
Carbon Monoxide Inhibits the Expression of Proteins Associated with Intestinal Mucosal Pyroptosis in a Rat Model of Sepsis Induced by Cecal Ligation and Puncture.
Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis.
Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18.
Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses.
Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12.
Diagnostic value of apoptosis biomarkers in severe sepsis-A pilot study.
Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice.
Fli-1 transcription factor regulates the expression of caspase-1 in lung pericytes.
Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner.
Improved Emergency Myelopoiesis and Survival in Neonatal Sepsis by Caspase-1/11 Ablation.
Inflammasome expression and cytomegalovirus viremia in critically ill patients with sepsis.
Inflammasome mRNA expression in human monocytes during early septic shock.
Inhibition of caspase-1 activation in gram-negative sepsis and experimental endotoxemia.
Microvesicular caspase-1 mediates lymphocyte apoptosis in sepsis.
MiR-210-3p Enhances Cardiomyocyte Apoptosis and Mitochondrial Dysfunction by Targeting the NDUFA4 Gene in Sepsis-Induced Myocardial Dysfunction.
Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock.
Novel therapeutic targets for sepsis: regulation of exaggerated inflammatory responses.
Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators.
PAD2 Mediates Caspase-1 Associated Lethality in Pseudomonas Aeruginosa Pneumonia Induced Sepsis.
Protective effect of erythropoietin against lipopolysaccharide induced inflammation and mitochondrial damage in liver.
Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model.
Simultaneous activation of apoptosis and inflammation in pathogenesis of septic shock: a hypothesis.
Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes.
Targeting caspase-1 in sepsis: a novel approach to an old problem.
TEMPORARY REMOVAL: An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis.
The activation of IL-17 signaling pathway promotes pyroptosis in pneumonia-induced sepsis.
The impact of caspase-12 on susceptibility to candidemia.
The inflammatory caspases: guardians against infections and sepsis.
TLR4 and NLRP3 Caspase 1- IL-1?- Axis are not Involved in Colon Ascendens Stent Peritonitis (Casp)-Associated Heart Disease.
Toll-Like Receptor 4 and NLRP3 Caspase 1- Interleukin-1?-Axis are Not Involved in Colon Ascendens Stent Peritonitis-Associated Heart Disease.
[Activation of NOD-like receptor protein 3 inflammasome mediates inflammatory response and apoptosis in septic intestinal injury model].
[Effects of resveratrol-mediated inhibition of NOD-like receptor protein 3 inflammasomevia activating silent information regulator 1 on the injury of intestinal mucosal barrier function after sepsis].
Sepsis-Associated Encephalopathy
Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis.
Severe Dengue
CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages.
Shock, Septic
Gastrodin alleviates inflammatory injury of cardiomyocytes in septic shock mice via inhibiting NLRP3 expression.
Inflammasome mRNA expression in human monocytes during early septic shock.
Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Modeling caspase-1 inhibition: Implications for catalytic mechanism and drug design.
Non-invasive in vivo imaging of caspase-1 activation enables rapid and spatiotemporal detection of acute and chronic inflammatory disorders.
Sequential changes of NLRP3 inflammasome activation in sepsis and its relationship with death.
Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock.
The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock.
Silicosis
Effects of the Interactions between Dust Exposure and Genetic Polymorphisms in Nalp3, Caspase-1, and IL-1? on the Risk of Silicosis: A Case-Control Study.
[Expression and significance of NLRP3/IL-1?/TGF-?(1) signal axis in rat model of silicosis pulmonary fibrosis].
Skin Diseases
IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions.
Increased expression of caspase-1 and interleukin-18 in peeling skin disease, and a novel mutation of corneodesmosin.
Induction of biologically active IL-1 beta-converting enzyme and mature IL-1 beta in human keratinocytes by inflammatory and immunologic stimuli.
When Beauty Is Skin Deep: Regulation of the Wound Response by Caspase-8, RIPK3, and the Inflammasome.
Skin Neoplasms
Caspase-1 Activity Is Required for UVB-Induced Apoptosis of Human Keratinocytes.
Smoldering Multiple Myeloma
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.
Spinal Cord Injuries
Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model.
Effect of VX?765 on the transcriptome profile of mice spinal cords with acute injury.
Estrogen Attenuates Local Inflammasome Expression and Activation after Spinal Cord Injury.
Exosome-mediated inflammasome signaling after central nervous system injury.
Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis.
Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury.
Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury.
VX-765 reduces neuroinflammation after spinal cord injury in mice.
Spondylarthropathies
Caspase-1 level in synovial fluid is high in patients with spondyloarthropathy but not in patients with gout.
Sporotrichosis
Involvement of major components from Sporothrix schenckii cell wall in the caspase-1 activation, nitric oxide and cytokines production during experimental sporotrichosis.
Squamous Cell Carcinoma of Head and Neck
CD38 triggers inflammasome-mediated pyroptotic cell death in head and neck squamous cell carcinoma.
Expression of Inflammasome-Associated Proteins in Human Oropharyngeal Squamous Cell Carcinoma.
ST Elevation Myocardial Infarction
The 5352 A allele of the pro-inflammatory caspase-1 gene predicts late-acquired stent malapposition in STEMI patients treated with sirolimus stents.
Starvation
?-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation.
Status Epilepticus
Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus.
Stomach Diseases
Caspase-1 Has Both Pro-Inflammatory and Regulatory Properties in Helicobacter Infections, Which Are Differentially Mediated by Its Substrates IL-1? and IL-18.
Stomach Neoplasms
Caspase-1 activity as a possible predictor of apoptosis induced by cisplatin in gastric cancer cells.
Caspase-1 Has Both Pro-Inflammatory and Regulatory Properties in Helicobacter Infections, Which Are Differentially Mediated by Its Substrates IL-1? and IL-18.
Core 1-derived mucin-type O-glycosylation protects against spontaneous gastritis and gastric cancer.
Helicobacter pylori infection upregulates interleukin-18 production from gastric epithelial cells.
Loss of caspase-1 gene expression in human gastric carcinomas and cell lines.
Ornithine decarboxylase (ODC1) gene variant (rs2302615) is associated with gastric cancer independently of Helicobacter pylori CagA serostatus.
Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma.
Stomach Ulcer
[Effects of caspase-1 inhibitor VX765 on cold-restraint stress-induced acute gastric ulcer in mice].
Stroke
AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice.
Caspase inhibitors: a review of recently patented compounds (2013-2015).
Caspase-1 inhibition mediates neuroprotection in experimental stroke by polarizing M2 microglia/macrophage and suppressing NF-?B activation.
Does Caspase-6 Have a Role in Perinatal Brain Injury?
Effects of caspase-1 knockout on chronic neural recording quality and longevity: insight into cellular and molecular mechanisms of the reactive tissue response.
Inflammasome Proteins in Serum and Serum-Derived Extracellular Vesicles as Biomarkers of Stroke.
Inhibited CSF1R Alleviates Ischemia Injury via Inhibition of Microglia M1 Polarization and NLRP3 Pathway.
Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke.
Molecular mechanisms of cerebral ischemia-induced neuronal death.
Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-?B, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability.
Recent insights into the regulatory networks of NLRP3 inflammasome activation.
Subarachnoid Hemorrhage
Caspase-1 Inhibitor Prevents Neurogenic Pulmonary Edema After Subarachnoid Hemorrhage in Mice.
Inflammasome Caspase-1 Activity is Elevated in Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage and Predicts Functional Outcome.
Target inhibition of caspase-8 alleviates brain damage after subarachnoid hemorrhage.
Superinfection
Aggravated MRSA pneumonia secondary to influenza A virus infection is derived from decreased expression of IL-1?.
Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Syphilis
MiR-223-3p inhibits rTp17-induced inflammasome activation and pyroptosis by targeting NLRP3.
Testicular Neoplasms
Interleukin-1 superfamily genes expression in normal or impaired human spermatogenesis.
Thrombosis
Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia.
Inflammasome activation promotes venous thrombosis through pyroptosis.
Neutrophil extracellular traps and inflammasomes cooperatively promote venous thrombosis in mice.
Toll-Like Receptor 9 Signaling Is Critical for Early Experimental Deep Vein Thrombosis Resolution.
Thymoma
a-Tocopherol modifies the expression of genes related to oxidative stress and apoptosis during invitro maturation and enhances the developmental competence of rabbit oocytes.
Cypermethrin Alters the Expression Profile of mRNAs in the Adult Rat Striatum: A Putative Mechanism of Postnatal Pre-exposure Followed by Adulthood Re-exposure-Enhanced Neurodegeneration.
In vivo and in vitro maturation of rabbit oocytes differently affects the gene expression profile, mitochondrial distribution, apoptosis and early embryo development.
Thyroid Neoplasms
TRAIL-induced apoptosis of thyroid cancer cells: potential for therapeutic intervention.
Toxoplasmosis
A highly conserved toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage.
P2X7 receptor mediates NLRP3-dependent IL-1? secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells.
Tuberculosis
Caspase 1 and caspase 8 in HIV infected patients with and without tuberculosis.
Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo.
Caspase-1-Processed Cytokines IL-1{beta} and IL-18 Promote IL-17 Production by {gamma}{delta} and CD4 T Cells That Mediate Autoimmunity.
Critical role of AIM2 in Mycobacterium tuberculosis infection.
Geranylgeraniol regulates negatively caspase-1 autoprocessing: implication in the Th1 response against Mycobacterium tuberculosis.
Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1.
Hydroxymethylglutaryl-coenzyme A reductase inhibition stimulates caspase-1 activity and Th1-cytokine release in peripheral blood mononuclear cells.
Inhibition of the Plasma-Membrane-Associated Serine Protease Cathepsin G by Mycobacterium tuberculosis Rv3364c Suppresses Caspase-1 and Pyroptosis in Macrophages.
Microglial activation of the NLRP3 inflammasome by the priming signals derived from macrophages infected with mycobacteria.
Modulation of macrophage apoptosis by antimycobacterial therapy: physiological role of apoptosis in the control of Mycobacterium tuberculosis.
Modulation of the inflammatory process by statins.
Mycobacterium tuberculosis Induces Interleukin-32 Production through a Caspase- 1/IL-18/Interferon-gamma-Dependent Mechanism.
Mycobacterium tuberculosis infection causes different levels of apoptosis and necrosis in human macrophages and alveolar epithelial cells.
PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques.
Susceptibility to M tuberculosis infection in HIV-positive patients is associated with CARD8 genetic variant.
The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis Infection.
The RD1 locus in the Mycobacterium tuberculosis genome contributes to activation of caspase-1 via induction of potassium ion efflux in infected macrophages.
Tuberculosis, Pulmonary
Impaired interleukin-1beta converting enzyme (ICE) activity in patients with pulmonary tuberculosis.
Tularemia
Transcriptional profiling of Francisella tularensis infected peripheral blood mononuclear cells: a predictive tool for tularemia.
Typhoid Fever
Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever.
Salmonella exploits caspase-1 to colonize Peyer's patches in a murine typhoid model.
Uremia
The effect of uremia and hemodialysis on caspase-1 and caspase-3 activity in neutrophils.
Ureteral Obstruction
Role and Association of Inflammatory and Apoptotic Caspases in Renal Tubulointerstitial Fibrosis.
The NLRP3 inflammasome promotes renal inflammation and contributes to CKD.
Urologic Neoplasms
Overexpression of IL-1ra gene up-regulates interleukin-1beta converting enzyme (ICE) gene expression: possible mechanism underlying IL-1beta-resistance of cancer cells.
Urticaria
[Cryopyrin-associated periodic syndromes].
Uterine Cervical Neoplasms
Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.
Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death.
MiRNA-214 promotes the pyroptosis and inhibits the proliferation of cervical cancer cells via regulating the expression of NLRP3.
Uterine Neoplasms
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells.
Uveitis
NOD1 expression in the eye and functional contribution to IL-1beta-dependent ocular inflammation in mice.
The NLRP3 inflammasome is active but not essential in endotoxin-induced uveitis.
Vaccinia
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced fever.
Vaginitis
Secretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by Candida albicans in Mice.
Varicocele
Apoptosis-related proteins in the testes of infertile men with varicocele.
NLRP3 Inflammasome: A New Pharmacological Target for Reducing Testicular Damage Associated with Varicocele.
Varicose Veins
Weighted Gene Co-expression Network Analysis for RNA-Sequencing Data of the Varicose Veins Transcriptome.
Vasospasm, Intracranial
Antivasospastic and antiinflammatory effects of caspase inhibitor in experimental subarachnoid hemorrhage.
Venous Thrombosis
Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia.
Inflammasome activation promotes venous thrombosis through pyroptosis.
Viremia
Inflammasome expression and cytomegalovirus viremia in critically ill patients with sepsis.
Virus Diseases
Avian leukosis virus subgroup J triggers caspase-1-mediated inflammatory response in chick livers.
Bovine herpesvirus 1 productive infection stimulates inflammasome formation and caspase 1 activity.
Caspase 3 activation is essential for efficient influenza virus propagation.
Caspase-1 Deficient Mice Are More Susceptible to Influenza A Virus Infection With PA Variation.
Caspase-1 independent viral clearance and adaptive immunity against mucosal respiratory syncytial virus infection.
CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages.
Correlation of inducible nitric oxide synthase (iNOS) inhibition with TNF-?, caspase-1, FasL and TLR-3 in pathogenesis of rabies in mouse model.
Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA.
Human metapneumovirus activates NOD-like receptor protein 3 inflammasome via its small hydrophobic protein which plays a detrimental role during infection in mice.
Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression.
NLRP3 inflammasome activation and oxidative stress status in the mild and moderate SARS-CoV-2 infected patients: impact of melatonin as a medicinal supplement.
Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation.
Protective immunity to influenza: lessons from the virus for successful vaccine design.
Respiratory syncytial virus infection of human alveolar epithelial cells enhances interferon regulatory factor 1 and interleukin-1beta-converting enzyme gene expression but does not cause apoptosis.
Sendai Virus V Protein Inhibits the Secretion of Interleukin-1? by Preventing NLRP3 Inflammasome Assembly.
The Anti-inflammatory Effect of Alpha-1 Antitrypsin in Rhinovirus-infected Human Airway Epithelial Cells.
The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity.
Virus infection induces proteolytic processing of IL-18 in human macrophages via caspase-1 and caspase-3 activation.
Vitiligo
ATP-P2X7-Induced Inflammasome Activation Contributes to Melanocyte Death and CD8+ T-Cell Trafficking to the Skin in Vitiligo.
Whooping Cough
Caspase-1-independent interleukin-1? is required for clearance of Bordetella pertussis infections and whole-cell vaccine-mediated immunity.
Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis.
Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration.
Yersinia Infections
Analysis of Inflammasome Activation in Response to Yersinia Infection by Fluorescence Microscopy Detection of Active Caspase-1 Puncta.
Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality.
Zika Virus Infection
Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis.
Zika Virus Impairs Host NLRP3-mediated Inflammasome Activation in an NS3-dependent Manner.
Zika virus induces inflammasome activation in the glial cell line U87-MG.