Reference on EC 3.4.22.33 - Fruit bromelain
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rowan, A.D.; Buttle, D.J.; Barrett, A.J.
The cysteine proteinases of the pineapple plant
Biochem. J.
266
869-875
1990
plant, Bromelia pinguin
Ota, S.; Horie, K.; Hagino, F.; Hashimoto, C.; Date, H.
Fractionation and some properties of the proteolytically active components of bromelains in the stem and the fruit of the pineapple plant
J. Biochem.
71
817-830
1972
Ananas comosus
Ota, S.; Muta, E.; Katahira, Y.; Okamoto, Y.
Reinvestigation of fractionation and some properties of the proteolytically active components of stem and fruit bromelains
J. Biochem.
98
219-228
1985
Ananas comosus
Rowan, A.D.; Brzin, J.; Buttle, D.J.; Barrett, A.J.
Inhibition of cysteine proteinases by a protein inhibitor from potato
FEBS Lett.
269
328-330
1990
BRENDA: Ananas comosus
Textmining: Solanum tuberosum
Shipton, M.; Brocklehurst, K.
Benzofuroxan as a thiol-specific reactivity probe. Kinetics of its reactions with papain, ficin, bromelain and low-molecular-weight thiols
Biochem. J.
167
799-810
1977
Electron
Suh, H.J.; Lee, H.; Cho, H.Y.; Yang, H.C.
Purification and characterization of bromelain isolated from pineapple
Han'guk Nonghwa Hakhoechi
35
300-307
1992
Ananas comosus
-
Yamada, F.; Takahashi, N.; Murachi, T.
Purification and characterization of a proteinase from pineapple fruit, fruit bromelain FA2
J. Biochem.
79
1223-1234
1976
Ananas comosus
Sasaki, M.; Kato, T.; Iida, S.
Antigenic determinant common to four kinds of thiol proteases of plant origin
J. Biochem.
74
635-637
1973
Ananas comosus
Toro-Goyco, E.; Rodriguez-Costas, I.
Immunochemical studies on pinguinain. A sulfhydryl plant protease
Arch. Biochem. Biophys.
175
359-366
1976
Ananas comosus, Bromelia pinguin
Shigeta, S.; Kubota, H.; Tamura, H.
Purification and characterization of an alpha-mannosidase of sea-squirt
J. Biochem.
94
1827-1832
1983
Saccharomyces cerevisiae
Maurer, H.R.
Bromelain: biochemistry, pharmacology and medical use
Cell. Mol. Life Sci.
58
1234-1245
2001
Ananas comosus
Harrach, T.; Eckert, K.; Maurer, H.R.; Machleidt, I.; Machleidt, W.; Nuck, R.
Isolation and characterization of two forms of an acidic bromelain stem proteinase
J. Protein Chem.
17
351-361
1998
Ananas comosus
Rowan, A.D.
Fruit bromelain
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
2
1137-1138
2004
Ananas comosus
-
Hale, L.P.; Greer, P.K.; Trinh, C.T.; James, C.L.
Proteinase activity and stability of natural bromelain preparations
Int. Immunopharmacol.
5
783-793
2005
Ananas comosus
Hemavathi, A.B.; Hebbar, H.U.; Raghavarao, K.S.
Reverse micellar extraction of bromelain from Ananas comosus L. Merryl
J. Chem. Technol. Biotechnol.
82
985-992
2007
Ananas comosus (O23791)
-
Cabral, H.; Leopoldino, A.M.; Tajara, E.H.; Greene, L.J.; Faca, V.M.; Mateus, R.P.; Ceron, C.R.; de Souza Judice, W.A.; Julianod, L.; Bonilla-Rodriguez, G.O.
Preliminary functional characterization, cloning and primary sequence of Fastuosain, a cysteine peptidase isolated from fruits of Bromelia fastuosa
Protein Pept. Lett.
13
83-89
2006
BRENDA: Bromelia fastuosa (Q6Q2T4), Bromelia fastuosa
Textmining: Bromeliaceae
Shukor, M.Y.; Masdor, N.; Baharom, N.A.; Jamal, J.A.; Abdullah, M.P.; Shamaan, N.A.; Syed, M.A.
An inhibitive determination method for heavy metals using bromelain, a cysteine protease
Appl. Biochem. Biotechnol.
144
283-291
2008
Ananas comosus
Fitzhugh, D.J.; Shan, S.; Dewhirst, M.W.; Hale, L.P.
Bromelain treatment decreases neutrophil migration to sites of inflammation
Clin. Immunol.
128
66-74
2008
Ananas comosus, Mus musculus
Secor, E.R.; Carson, W.F.; Singh, A.; Pensa, M.; Guernsey, L.A.; Schramm, C.M.; Thrall, R.S.
Oral bromelain attenuates inflammation in an ovalbumin-induced murine model of asthma
Evid. Based. Complement Alternat. Med.
5
61-69
2008
Ananas comosus
Chobotova, K.; Vernallis, A.B.; Majid, F.A.
Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives
Cancer Lett.
290
148-156
2010
Ananas comosus
Neuteboom, L.W.; Matsumoto, K.O.; Christopher, D.A.
An extended AE-rich N-terminal trunk in secreted pineapple cystatin enhances inhibition of fruit bromelain and is posttranslationally removed during ripening
Plant Physiol.
151
515-527
2009
BRENDA: Ananas comosus (O23791), Ananas comosus
Textmining: plant
Liang, H.; Li, M.; Shi, M.; Liao, A.; Wu, R.
Study on the stability of fruit bromelain
Adv. Mater. Res.
421
19-22
2012
Ananas comosus
-
Ferreira, J.; Bresolin, L.; Silveira, E.; Tambourgi, E.
Purification of bromelain from ananas comosus by PEG/phosphate ATPS
Chem. Eng. Transact.
24
931-936
2011
Ananas comosus
-
Yin, L.; Sun, C.; Han, X.; Xu, L.; Xu, Y.; Qi, Y.; Peng, J.
Preparative purification of bromelain (EC 3.4.22.33) from pineapple fruit by high-speed counter-current chromatography using a reverse-micelle solvent system
Food Chem.
129
925-932
2011
Ananas comosus
Gautam, S.; Mishra, S.; Dash, V.; Goyal, A.; Rath, G.
Comparative study of extraction, purification and estimation of bromelain from stem and fruit of pineapple plant
Thai J. Pharm. Sci.
34
67-76
2010
Ananas comosus
-
Arshad, Z.I.; Amid, A.; Yusof, F.; Jaswir, I.; Ahmad, K.; Loke, S.P.
Bromelain: an overview of industrial application and purification strategies
Appl. Microbiol. Biotechnol.
98
7283-7297
2014
Ananas comosus (O23791), Ananas comosus
Corzo, C.; Waliszewski, K.; Welti-Chanes, J.
Pineapple fruit bromelain affinity to different protein substrates
Food Chem.
133
631-635
2012
Ananas comosus (O23791)
Devi, Y.; Rupachandra Singh, L.; Kunjeshwori Devi, S.
Pineapple fruit bromelain and its application: A review
Indian J. Agric. Biochem.
25
1-7
2012
Ananas comosus (O23791)
-
Lopez-Garcia, B.; Hernandez, M.; Segundo, B.S.
Bromelain, a cysteine protease from pineapple (Ananas comosus) stem, is an inhibitor of fungal plant pathogens
Lett. Appl. Microbiol.
55
62-67
2012
Ananas comosus, plant
Mohan, R.; Sivakumar, V.; Rangasamy, T.; Muralidharan, C.
Optimisation of bromelain enzyme extraction from pineapple (Ananas comosus) and application in process industry
Am. J. Biochem. Biotechnol.
12
188-195
2016
Ananas comosus (O23791)
-
Misran, E.; Idris, A.; Mat Sarip, S.; Yaakob, H.
Properties of bromelain extract from different parts of the pineapple variety Morris
Biocatal. Agricult. Biotechnol.
18
101095
2019
Ananas comosus
-
Ramli, A.N.M.; Manas, N.H.A.; Hamid, A.A.A.; Hamid, H.A.; Illias, R.M.
Comparative structural analysis of fruit and stem bromelain from Ananas comosus
Food Chem.
266
183-191
2018
Ananas comosus (O23791), Ananas comosus
Meza-Espinoza, L.; de Los Angeles Vivar-Vera, M.; de Lourdes Garcia-Magana, M.; Sayago-Ayerdi, S.G.; Chacon-Lopez, A.; Becerrea-Verdin, E.M.; Montalvo-Gonzalez, E.
Enzyme activity and partial characterization of proteases obtained from Bromelia karatas fruit and compared with Bromelia pinguin proteases
Food Sci. Biotechnol.
27
509-517
2018
Bromelia pinguin, Bromelia karatas
Chakraborty, S.; Rao, P.; Mishra, H.
Modeling the inactivation kinetics of fruit bromelain in pineapple during high-pressure and thermal treatments
Innov. Food Sci. Emerg. Technol.
33
10-18
2016
Ananas comosus (O23791)
-
Sao Paulo Barretto Miranda, I.K.; Fontes Suzart Miranda, A.; Souza, F.V.; Vannier-Santos, M.A.; Pirovani, C.P.; Pepe, I.M.; Rodowanski, I.J.; Ferreira, K.T.; Mendes Souza Vaz, L.; de Assis, S.A.
The biochemical characterization, stabilization studies and the antiproliferative effect of bromelain against B16F10 murine melanoma cells
Int. J. Food Sci. Nutr.
68
442-454
2017
Ananas comosus (O23791), Ananas comosus (O23801), Ananas comosus AGB 772 (O23791), Ananas comosus AGB 772 (O23801)
Das, S.; Bhattacharyya, D.
Destabilization of human insulin fibrils by peptides of fruit bromelain derived from Ananas comosus (pineapple)
J. Cell. Biochem.
118
4881-4896
2017
BRENDA: Ananas comosus (O23791), Ananas comosus
Textmining: Homo sapiens
Ghensi, P.; Cucchi, A.; Bonaccorso, A.; Ferroni, L.; Gardin, C.; Mortellaro, C.; Zavan, B.
In vitro effect of bromelain on the regenerative properties of mesenchymal stem cells
J. Craniofac. Surg.
30
1064-1067
2019
Ananas comosus (O24641)
Andjaitan, M.; Tutunnugrah, T.; Pamudja, K.; Idris, F.; Tjandra, M.; Wiriantono, T.
Bromelain enzyme from pineapple fruit as an antiviral agent against HIV, hepatitis C and human papiloma virus
J. Eng. Appl. Sci.
13
3125-3130
2018
Ananas comosus (O23791)
-
Zhi, N.; Zong, K.; Jia, X.; Wang, L.; Liang, J.
Effect of high pressure processing on fibrinolytic activity of fruit bromelain in vivo
J. Food Process Eng.
42
e13146
2019
Ananas comosus (O23791)
-
Kaur, T.; Kaur, A.; Grewal, R.K.
Kinetics studies with fruit bromelain (Ananas comosus) in the presence of cysteine and divalent ions
J. Food Sci. Technol.
52
5954-5960
2015
Ananas comosus (O23791)
Baur, X; Fruhmann, G
Allergic reactions, including asthma, to the pineapple protease bromelain following occupational exposure.
Clin Allergy
9
443-50
1979
Ananas comosus
Mine, T; Fujii, I; Hata, S
[Clinical study on the effect of ananase (a new oral plant protease concentrate) on the ocular diseases]
Nippon Ganka Kiyo
17
688-94
1966
plant
Mynott, TL; Luke, RK; Chandler, DS
Oral administration of protease inhibits enterotoxigenic Escherichia coli receptor activity in piglet small intestine.
Gut
38
28-32
1996
Ananas comosus, Sus scrofa
MARTIN, GJ; EHRENREICH, J; ASBELL, N
[BROMELIN, A PROTEASE OF PINEAPPLE WITH ANTIEDEMA ACTION (ANANASE).]
Minerva Med
56
SUPPL:13-22
1965
Ananas comosus
Fukuda, M; Kondo, T; Osawa, T
Studies on the hydrazinolysis of glycoproteins. Core structures of oligosaccharides obtained from Porcine thyroglobulin and pineapple stem bromelain.
J Biochem (Tokyo)
80
1223-32
1976
Ananas comosus, Sus scrofa
Lotz-Winter, H
On the pharmacology of bromelain: an update with special regard to animal studies on dose-dependent effects.
Planta Med
56
249-53
1990
animal, Ananas comosus, Metazoa, plant
Mynott, TL; Guandalini, S; Raimondi, F; Fasano, A
Bromelain prevents secretion caused by Vibrio cholerae and Escherichia coli enterotoxins in rabbit ileum in vitro.
Gastroenterology
113
175-84
1997
Ananas comosus
Chandler, DS; Mynott, TL
Bromelain protects piglets from diarrhoea caused by oral challenge with K88 positive enterotoxigenic Escherichia coli.
Gut
43
196-202
1998
Ananas comosus
Mynott, TL; Ladhams, A; Scarmato, P; Engwerda, CR
Bromelain, from pineapple stems, proteolytically blocks activation of extracellular regulated kinase-2 in T cells.
J Immunol
163
2568-75
1999
Ananas comosus
Secor, ER; Carson, WF; Cloutier, MM; Guernsey, LA; Schramm, CM; Wu, CA; Thrall, RS
Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease.
Cell Immunol
237
68-75
2005
Ananas comosus
Massimiliano, R; Pietro, R; Paolo, S; Sara, P; Michele, F
Role of bromelain in the treatment of patients with pityriasis lichenoides chronica.
J Dermatolog Treat
18
219-22
2007
Ananas comosus
Garbin, F; Harrach, T; Eckert, K; Maurer, H
Bromelain proteinase-f9 augments human lymphocyte-mediated growth-inhibition of various tumor-cells in-vitro.
Int J Oncol
5
197-203
1994
Ananas comosus
Muntari, B; Amid, A; Mel, M; Jami, MS; Salleh, HM
Recombinant bromelain production in Escherichia coli: process optimization in shake flask culture by response surface methodology.
AMB Express
2
12
2012
Escherichia coli
Sancesario, GM; Nuccetelli, M; Cerri, A; Zegeer, J; Severini, C; Ciotti, MT; Pieri, M; Martorana, A; Caltagirone, C; Nistico, R; Bernardini, S
Bromelain degrades A?1-42 monomers and soluble aggregates: an in vitro study in cerebrospinal fluid of Alzheimer's disease patients.
Curr Alzheimer Res
2018
Ananas comosus, plant
Nor, MZM; Ramchandran, L; Duke, M; Vasiljevic, T
Performance of a Two-Stage Membrane System for Bromelain Separation from Pineapple Waste Mixture as Impacted by Enzymatic Pretreatment and Diafiltration.
Food Technol Biotechnol
56
218-227
2018
Ananas comosus
Nwagu, TN; Ugwuodo, CJ
Stabilizing bromelain for therapeutic applications by adsorption immobilization on spores of probiotic Bacillus.
Int J Biol Macromol
127
406-414
2019
Ananas comosus, plant
Razali, R; Budiman, C; Kamaruzaman, KA; Subbiah, VK
Soluble Expression and Catalytic Properties of Codon-Optimized Recombinant Bromelain from MD2 Pineapple in Escherichia coli.
Protein J
40
406-418
2021
Ananas comosus
Yin L;Sun CK;Han X;Xu L;Xu Y;Qi Y;Peng J
Preparative purification of bromelain (EC 3.4.22.33) from pineapple fruit by high-speed counter-current chromatography using a reverse-micelle solvent system
Food chemistry
129
925-932
2011
Ananas comosus
Waters, CA; Makens, MA
Rapid fluorescent-antibody method with bromelase for identification of group A streptococci.
J Clin Microbiol
5
255-6
1977
Streptococcus sp. 'group A'
Vidal, GP; Sasaki, M
Limited proteolysis of human IgG by fruit bromelain.
J Biochem (Tokyo)
74
497-503
1973
Homo sapiens
Karl, M; Burkhardt, K; Backhausz, R; Fickert, G; Lajos, J
Immunochemical investigations of bromelin fragments of normal human IgG.
Ann Immunol Hung
16
217-27
1972
Homo sapiens
Levine, N; Seifter, E; Connerton, C; Levenson, SM
Debridement of experimental skin burns of pigs with bromelain, a pineapple-stem enzyme.
Plast Reconstr Surg
52
413-24
1973
Suidae
Cawley, LP; Goodwin, WL
Electron microscopic investigation of the binding of bromelin by erythrocytes.
Vox Sang
13
393-405
1967
Electron
Waller, M; Curry, N; Mallory, J
Immunochemical and serological studies of enzymatically fractionated human IgG globulins. I. Hydrolysis with pepsin, papain, ficin and bromelin.
Immunochemistry
5
577-83
1968
Homo sapiens
Cawley, LP; Schneider, D; Eberhardt, L
Immunoelectrophoretic and serologic study of the immunologically active components of bromelin with rabbit anti-bromelin.
Vox Sang
11
81-9
0
Oryctolagus cuniculus
Taub, SJ
The use of Ananase in sinusitis. A study of 60 patients.
Eye Ear Nose Throat Mon
45
96 passim
1966
Homo sapiens
Barbarino, F; Szabó, P; Neumann, E
The influence of bromelin on digestion and absorption in control animals and in methotrexate-induced "cytostatic" enteropathy.
J Nucl Med Allied Sci
26
97-103
0
Metazoa
DAOULAS LE BOURDELLES, F; FINE, JM
[Detection of anti-Rh antibodies using protease-treated erythrocytes; comparative use of 2 plant proteases: papain and bromelin.]
C R Seances Soc Biol Fil
150
1388-90
1956
plant
PERONA, G; CORTESI, S; GHIOTTO, G; DESANDRE, G
LOSS OF ACETYLCHOLINESTERASE IN HUMAN ERYTHROCYTES TREATED WITH TRYPSIN, PAPAIN OR BROMELIN: ITS RELATIONSHIP WITH SUSCEPTIBILITY TO ACID LYSIS IN VITRO.
Br J Haematol
11
171-6
1965
Homo sapiens
CIRELLI, MG
[TREATMENT OF INFLAMMATION AND EDEMA WITH BROMELIN. A CONCENTRATED PLANT PROTEOLYTIC ENZYME.]
Minerva Med
56
SUPPL:29-33
1965
plant
KULHANEK, V; MAJSKY, A
[PROTEINASE INHIBITORS IN HUMAN SERUM AS THE CAUSE OF THE PROZONE PHENOMENON IN THE PIROFSKY BROMELIN TEST.]
Z Immunitats Allergieforsch
128
72-80
1965
Homo sapiens
Miller, EV; Hall, GD
Distribution of Total Soluble Solids, Ascorbic Acid, Total Acid, and Bromelin Activity in The Fruit of the Natal Pineapple (Ananas Comosus L. MERR.).
Plant Physiol
28
532-4
1953
Ananas comosus
Chittenden, RH
On the Proteolytic Action of Bromelin, the Ferment of Pineapple Juice.
J Physiol
15
249-310
1893
Ananas comosus
Guimarães-Ferreira, CA; Rodrigues, EG; Mortara, RA; Cabral, H; Serrano, FA; Ribeiro-dos-Santos, R; Travassos, LR
Antitumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cysteine proteinase from Bromelia fastuosa.
Neoplasia
9
723-33
2007
Bromelia fastuosa, Mus musculus, Mus sp., Metazoa
Winnick, T; Davis, AR; Greenberg, DM
PHYSICOCHEMICAL PROPERTIES OF THE PROTEOLYTIC ENZYME FROM THE LATEX OF THE MILKWEED, ASCLEPIAS SPECIOSA TORR. SOME COMPARISONS WITH OTHER PROTEASES : III. KINETICS OF THE HEAT INACTIVATION OF PAPAIN, BROMELIN, AND ASCLEPAIN.
J Gen Physiol
23
301-308
1940
Asclepias speciosa
PETERMANN, ML
The splitting of human gamma globulin antibodies by papain and bromelin.
J Am Chem Soc
68
106-13
1946
Homo sapiens
Borrelli, F; Capasso, R; Severino, B; Fiorino, F; Aviello, G; De Rosa, G; Mazzella, M; Romano, B; Capasso, F; Fasolino, I; Izzo, AA
Inhibitory effects of bromelain, a cysteine protease derived from pineapple stem (Ananas comosus), on intestinal motility in mice.
Neurogastroenterol Motil
23
745-e331
2011
Ananas comosus, Mus sp.
Owoyele, BV; Bakare, AO; Ologe, MO
Bromelain: A Review on its Potential as a Therapy for the Management of Covid-19.
Niger J Physiol Sci
35
10-19
2020
Severe acute respiratory syndrome coronavirus 2
Corzo CA;Waliszewski KN;Welti-Chanes J
Pineapple fruit bromelain affinity to different protein substrates
Food chemistry
133
631-635
2012
Ananas comosus
Nakamura, S; Iwanaga, S; Suzuki, T
On the activation of bovine plasma factor XIII. Amino acid sequence of the peptide released by thrombin and the terminal residues of the subunit polypeptides.
J Biochem (Tokyo)
78
1247-66
1975
Bos taurus, Homo sapiens, Rattus
Mühlfeld, J; Sachs, V
[Influence of sound and enzyme treatment on antigenic properties of human erythrocytes. II. Enzyme treatment]
Blut
30
289-94
1975
Homo sapiens
Matagne, A; Bolle, L; El Mahyaoui, R; Baeyens-Volant, D; Azarkan, M
The proteolytic system of pineapple stems revisited: Purification and characterization of multiple catalytically active forms.
Phytochemistry
138
29-51
2017
Ananas comosus
valos-Flores, E; Lpez-Castillo, LM; Wielsch, N; Hupfer, Y; Winkler, R; Magaa-Ortiz, D
Protein extract of Bromelia karatas L. rich in cysteine proteases (ananain- and bromelain-like) has antibacterial activity against foodborne pathogens Listeria monocytogenes and Salmonella Typhimurium.
Folia Microbiol (Praha)
2021
Ananas comosus, Bromelia karatas
Siniakov, MS; Kharitonenkov, IG; Grigorjev, VB
Structure of bromelain-released influenza virus haemagglutinin as revealed by electrophoresis, sedimentation and electron microscopy.
Arch Virol
62
145-62
1979
Electron, influenza A virus, Viruses
Katz, F; Moats, W; Jan, YN
A carbohydrate epitope expressed uniquely on the cell surface of Drosophila neurons is altered in the mutant nac (neurally altered carbohydrate).
EMBO J
7
3471-7
1988
Ananas comosus, plant
Fujiyoshi, T; Hayashi, I; Oh-ishi, S
Kaolin-induced writhing response in mice: activation of the plasma kallikrein-kinin system by kaolin.
J Pharmacobiodyn
12
483-7
1989
Mus sp.
Houck, JC; Chang, CM; Klein, G
Isolation of an effective debriding agent from the stems of pineapple plants.
Int J Tissue React
5
125-34
1983
Ananas comosus, plant
Mynott, TL; Crossett, B; Prathalingam, SR
Proteolytic inhibition of Salmonella enterica serovar typhimurium-induced activation of the mitogen-activated protein kinases ERK and JNK in cultured human intestinal cells.
Infect Immun
70
86-95
2002
Escherichia coli, Ananas comosus
Hale, LP; Chichlowski, M; Trinh, CT; Greer, PK
Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis.
Inflamm Bowel Dis
2010
Ananas comosus
Leite, MS; Fujiki, TL; Silva, FV; Fileti, AM
Online intelligent controllers for an enzyme recovery plant: design methodology and performance.
Enzyme Res
2010
250843
2010
plant, Ananas comosus
Luoga, W; Mansur, F; Buttle, DJ; Duce, IR; Garnett, MC; Lowe, A; Behnke, JM
The relative anthelmintic efficacy of plant-derived cysteine proteinases on intestinal nematodes.
J Helminthol
1-10
2013
Actinidia deliciosa, Carica papaya, Hemigraphis bakeri, Electron
Mansur, F; Luoga, W; Buttle, DJ; Duce, IR; Lowe, A; Behnke, JM
The anthelmintic efficacy of natural plant cysteine proteinases against two rodent cestodes Hymenolepis diminuta and Hymenolepis microstoma in vitro.
Vet Parasitol
201
48-58
2014
Hymenolepis diminuta, Rodentia, Hymenolepis microstoma, Carica papaya
Negoro, S; Takashima, T; Fujiwara, H; Tsuyuguchi, I
Regulatory mechanism of autoantibody production in mice to bromelin-treated isologous red blood cells.
Immunology
36
257-64
1979
Mus sp., Rattus
Sagisaka, K; Sugiyama, Y; Tsugawa, N
Fragmentation of human albumin with proteolytic enzymes and its antigenicity with special reference to human-specificity.
Tohoku J Exp Med
125
115-20
1978
Homo sapiens
Bussard, A; Rattner, E; Vanko, L; Pages, J
[Multiple expressions of mouse peritoneal cell immune potential]
Ann Immunol (Paris)
128
319-21
0
Mus musculus, Mus sp., Ovis aries
Kasturi, KN; Mayer, R; Bona, CA; Scott, VE; Sidman, CL
Germline V genes encode viable motheaten mouse autoantibodies against thymocytes and red blood cells.
J Immunol
145
2304-11
1990
Mus musculus
Walker, MR; Woof, JM; Brüggemann, M; Jefferis, R; Burton, DR
Interaction of human IgG chimeric antibodies with the human FcRI and FcRII receptors: requirements for antibody-mediated host cell-target cell interaction.
Mol Immunol
26
403-11
1989
Homo sapiens
Stepek, G; Buttle, DJ; Duce, IR; Lowe, A; Behnke, JM
Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro.
Parasitology
130
203-11
2005
Ananas comosus
Sim?ek, Z; Alt?nba?, A; Deliba??, T; Yksel, O
Incomplete stomach emptying as a complication of intragastric balloon treatment and a solution suggestion: Pineapple juice drinking.
Turk J Gastroenterol
24
330-3
2013
Ananas comosus
Peixoto, DM; Rizzo, JA; Schor, D; Silva, AR; Oliveira, DC; Sol, D; Sarinho, E
Use of honey associated with Ananas comosus (Bromelin) in the treatment of acute irritative cough.
Rev Paul Pediatr
2016
Homo sapiens
Sripan, P; Aukkanimart, R; Boonmars, T; Sriraj, P; Songsri, J; Boueroy, P; Khueangchaingkhwang, S; Pumhirunroj, B; Artchayasawat, A
Application of Pineapple Juice in the Fish Digestion Process for Carcinogenic Liver Fluke Metacercaria Collection
Asian Pac J Cancer Prev
18
779-782
2017
Ananas comosus, Chondrichthyes
Oduwole, O; Udoh, EE; Oyo-Ita, A; Meremikwu, MM
Honey for acute cough in children.
Cochrane Database Syst Rev
4
CD007094
2018
Homo sapiens, Bromeliaceae
Kim, DS; Joo, N
Texture Characteristics of Horse Meat for the Elderly Based on the Enzyme Treatment.
Food Sci Anim Resour
40
74-86
2020
Equus caballus
Vellini, M; Desideri, D; Milanese, A; Omini, C; Daffonchio, L; Hernandez, A; Brunelli, G
Possible involvement of eicosanoids in the pharmacological action of bromelain.
Arzneimittelforschung
36
110-2
1986
Ananas comosus
Batkin, S; Taussig, SJ; Szekerezes, J
Antimetastatic effect of bromelain with or without its proteolytic and anticoagulant activity.
J Cancer Res Clin Oncol
114
507-8
1988
Mus sp., plant
Brien, S; Lewith, G; Walker, AF; Middleton, R; Prescott, P; Bundy, R
Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study.
QJM
99
841-50
2006
Ananas comosus
Zaman, M; Ehtram, A; Chaturvedi, SK; Nusrat, S; Khan, RH
Amyloidogenic behavior of different intermediate state of stem bromelain: A biophysical insight.
Int J Biol Macromol
91
477-85
2016
Ananas comosus
Murthy, SS; Narsaiah, TB
Cytotoxic Effect of Bromelain on HepG2 Hepatocellular Carcinoma Cell Line.
Appl Biochem Biotechnol
193
1873-1897
2021
Ananas comosus
Ogasawara, K; Mazda, T; Shimizu, M
The identification of inhibitors in bromelin one-stage irregular antibody screening techniques.
Blut
54
51-5
1987
Homo sapiens
Shulman, S; Gray, BA; Stevens, L
Studies on local immunity to sperm-dissolving of cervical mucus by use of bromelin with retention of antibody activity.
Am J Reprod Immunol
1
49-52
1980
Homo sapiens
Ingerslev, HJ; Poulsen, F
Bromelin for liquefaction of cervical mucus in sperm antibody testing: its effect on spermagglutinating immunoglobulin G.
Fertil Steril
33
61-3
1980
Homo sapiens
Zhou, Z; Wang, L; Feng, P; Yin, L; Wang, C; Zhi, S; Dong, J; Wang, J; Lin, Y; Chen, D; Xiong, Y; Peng, J
Inhibition of Epithelial TNF-? Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis.
Front Immunol
8
1468
2017
Rattus
Sinurat, PP; Sjahrir, H; Rambe, AS; Ganie, RA
The Alteration of Plasma Matrix Metalloproteinase-9 Level after the Addition of Bromelin 500 mg to Standard Therapy of Acute Ischemic Stroke and Its Correlation with Outcome.
Open Access Maced J Med Sci
6
624-628
2018
Homo sapiens
Han, Z; Kraiyot, S; Kittikun, AH; Zhou, W; Li, J
Fractionation and activity profiling of fruit bromelain from pineapples of Phuket variety growing in Thailand.
J Food Biochem
e13011
2019
Ananas comosus
Pang, WC; Ramli, ANM; Hamid, AAA
Comparative modelling studies of fruit bromelain using molecular dynamics simulation.
J Mol Model
26
142
2020
Ananas comosus
Hidaka, M; Nagata, M; Kawano, Y; Sekiya, H; Kai, H; Yamasaki, K; Okumura, M; Arimori, K
Inhibitory effects of fruit juices on cytochrome P450 2C9 activity in vitro.
Biosci Biotechnol Biochem
72
406-11
2008
Ananas comosus
Pérez-Jáuregui, J; Escate-Cavero, A; Vega-Galina, J; Ruiz-Argüelles, GJ; Macip-Nieto, G
[Probable coumarin poisoning upon ingestion of an anti-inflammatory agent]
Rev Invest Clin
47
311-3
0
Homo sapiens
Rieu, D; Bizot, B; Monis, M; Taib, M; Bonnet, H; Jean, R
[Neonatal jaundice due to anti-D allo-immunization with negative direct Coombs' test]
Arch Fr Pediatr
32
UNKNOWN
0
Homo sapiens
Kretschmer, V; Heuckeroth, A; Schulzki, T; Dietrich, G
[Superiority of the gel centrifugation method (ID System) in detection of erythrocyte antibodies]
Beitr Infusionsther
30
375-7
1992
Bos taurus
Kretschmer, V; Heuckeroth, A; Schulzki, T; Dietrich, G
Superiority of gel centrifugation in antibody screening and identification.
Infusionsther Transfusionsmed
19
226-30
1992
Bos taurus
Kobilinsky, L; Harrington, JJ
Detection and use of salivary hemagglutinins for forensic blood grouping.
J Forensic Sci
33
396-403
1988
Indicator
Leach, MF; AuBuchon, JP
Use of enzyme treatment to enhance reactivity of HLA and platelet-specific antibodies in solid-phase RBC adherence assays.
Transfusion
42
476-80
2002
Homo sapiens, Purpura
Pellicano, R; Strona, S; Simondi, D; Reggiani, S; Pallavicino, F; Sguazzini, C; Bonagura, AG; Rizzetto, M; Astegiano, M
Benefit of dietary integrators for treating functional dyspepsia: a prospective pilot study.
Minerva Gastroenterol Dietol
55
227-35
2009
Helicobacter pylori, Homo sapiens
Trusek, A; Kijak, E
Drug Carriers Based on Graphene Oxide and Hydrogel: Opportunities and Challenges in Infection Control Tested by Amoxicillin Release.
Materials (Basel)
14
2021
plant
Silva MEMPE;Mazzilli RN;Cusin F
Composition of hydrolysates from meat.
Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems
12
219-225
1999
Ananas comosus, Bos taurus, Gallus gallus, Meleagris gallopavo
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