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Disease on EC 3.4.22.29 - picornain 2A

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Habitual
Decreased USP2a Expression Inhibits Trophoblast Invasion and Associates With Recurrent Miscarriage.
Adenocarcinoma
MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer.
USP2a alters chemotherapeutic response by modulating redox.
Adenocarcinoma of Lung
USP2a Supports Metastasis by Tuning TGF-? Signaling.
Breast Neoplasms
MdmX is a substrate for the deubiquitinating enzyme USP2a.
Carcinoma
Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas.
Carcinoma, Embryonal
MdmX is a substrate for the deubiquitinating enzyme USP2a.
Carcinoma, Hepatocellular
Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A.
Cardiomyopathies
Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: a genetic predisposition to viral heart disease.
Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside.
Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy.
Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy.
Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy.
Nitric oxide inhibits dystrophin proteolysis by coxsackieviral protease 2A through S-nitrosylation: A protective mechanism against enteroviral cardiomyopathy.
Cardiomyopathy, Dilated
Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside.
Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy.
Selective delivery of nitric oxide to a cellular target: a pseudosubstrate-coupled dinitrosyl-iron complex inhibits the enteroviral protease 2A.
Common Cold
Solution structure of the 2A protease from a common cold agent, human rhinovirus C2, strain W12.
The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis.
Confusion
Multiple eIF4GI-specific protease activities present in uninfected and poliovirus-infected cells.
Conjunctivitis
Essential Role of Enterovirus 2A Protease in Counteracting Stress Granule Formation and the Induction of Type I Interferon.
Encephalomyelitis
Genetic analysis of mengovirus protein 2A: its function in polyprotein processing and virus reproduction.
Enterovirus Infections
Selective Removal of FG Repeat Domains from the Nuclear Pore Complex by Enterovirus 2A(pro).
Foot-and-Mouth Disease
Bovine viral diarrhea virus is a suitable viral vector for stable expression of heterologous gene when inserted in between N(pro) and C genes.
Expression of a foreign protein by influenza A virus.
Extremely efficient cleavage of eIF4G by picornaviral proteinases L and 2A in vitro.
Foot-and-mouth disease virus 2A protease mediates cleavage in attenuated Sabin 3 poliovirus vectors engineered for delivery of foreign antigens.
Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4 gamma.
Generation and characterization of an Npro-disrupted marker bovine viral diarrhea virus derived from a BAC cDNA.
Genomic sequence analyses of segments 1 to 6 of Dendrolimus punctatus cytoplasmic polyhedrosis virus.
Intact eukaryotic initiation factor 4G is required for hepatitis A virus internal initiation of translation.
NMR analysis of the interaction of picornaviral proteinases Lb and 2A with their substrate eukaryotic initiation factor 4GII.
Nucleotide sequence of genome segment 5 from Bombyx mori cypovirus 1.
Picornavirus internal ribosome entry segments: comparison of translation efficiency and the requirements for optimal internal initiation of translation in vitro.
Recognition of picornavirus internal ribosome entry sites within cells; influence of cellular and viral proteins.
Replicating foamy virus-based vectors directing high level expression of foreign genes.
Rhinovirus 2A proteinase mediated stimulation of rhinovirus RNA translation is additive to the stimulation effected by cellular RNA binding proteins.
Sindbis virus vectors designed to express a foreign protein as a cleavable component of the viral structural polyprotein.
The structures of picornaviral proteinases.
[Construction of recombinant yellow fever virus 17D containing 2A fragment as a vaccine vector]
Glioblastoma
Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma.
Glioma
Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas.
Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma.
Up-regulation of USP2a and FASN in gliomas correlates strongly with glioma grade.
Hand, Foot and Mouth Disease
Crystal Structure of 2A Proteinase from Hand, Foot and Mouth Disease Virus.
Heart Diseases
Structure and dynamics of coxsackievirus B4 2A proteinase, an enyzme involved in the etiology of heart disease.
Heart Failure
Nitric oxide inhibits dystrophin proteolysis by coxsackieviral protease 2A through S-nitrosylation: A protective mechanism against enteroviral cardiomyopathy.
Hepatitis A
Duck Hepatitis A virus possesses a distinct type IV internal ribosome entry site element of picornavirus.
The structures of picornaviral proteinases.
Hepatitis C
Picornavirus internal ribosome entry segments: comparison of translation efficiency and the requirements for optimal internal initiation of translation in vitro.
Subgenomic hepatitis C virus replicons inducing expression of a secreted enzymatic reporter protein.
Translation driven by picornavirus IRES is hampered from Sindbis virus replicons: rescue by poliovirus 2A protease.
Validating Enterovirus D68-2Apro as an Antiviral Drug Target and the Discovery of Telaprevir as a Potent D68-2Apro Inhibitor.
Infections
2A proteinase of human rhinovirus cleaves cytokeratin 8 in infected HeLa cells.
A thermosensitive mutant of HRV2 2A proteinase: evidence for direct cleavage of eIF4GI and eIF4GII.
Blockade of the poliovirus-induced cytopathic effect in neural cells by monoclonal antibody against poliovirus or the human poliovirus receptor.
Characterization of poliovirus 2A proteinase by mutational analysis: residues required for autocatalytic activity are essential for induction of cleavage of eukaryotic initiation factor 4F polypeptide p220.
Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro.
Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling.
Coxsackievirus Counters the Host Innate Immune Response by Blocking Type III Interferon Expression.
Cytoplasmic translocation, aggregation, and cleavage of TDP-43 by enteroviral proteases modulate viral pathogenesis.
Detection of infective poliovirus by a simple, rapid, and sensitive flow cytometry method based on fluorescence resonance energy transfer technology.
Efficient cleavage of p220 by poliovirus 2Apro expression in mammalian cells: effects on vaccinia virus.
Enterovirus 71 2A Protease Inhibits P-Body Formation To Promote Viral RNA Synthesis.
Enterovirus 71 inhibits cytoplasmic stress granule formation during the late stage of infection.
Enterovirus 71 protease 2Apro and 3Cpro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication.
Enterovirus D68 Protease 2Apro Targets TRAF3 To Subvert Host Innate Immune Responses.
Enterovirus Persistence in Cardiac Cells of Patients Suffering From Idiopathic Dilated Cardiomyopathy is Linked to 5' Terminal Genomic RNA-Deleted Viral Populations With Viral-Encoded Proteinase Activities.
Essential Role of Enterovirus 2A Protease in Counteracting Stress Granule Formation and the Induction of Type I Interferon.
Expression of poliovirus 2Apro in mammalian cells: effects on translation.
Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4 gamma.
HIV-1 transcripts use IRES-initiation under conditions where Cap-dependent translation is restricted by poliovirus 2A protease.
Human rhinovirus proteinase 2A induces T(H)1 and T(H)2 immunity in patients with chronic obstructive pulmonary disease.
Infection with enterovirus 71 or expression of its 2A protease induces apoptotic cell death.
Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy.
Interaction of 2A proteinase of human rhinovirus genetic group A with eIF4E is required for eIF4G cleavage during infection.
Involvement of membrane traffic in the replication of poliovirus genomes: effects of brefeldin A.
Picornavirus 2A protease regulates stress granule formation to facilitate viral translation.
Poliovirus 2A Protease Triggers a Selective Nucleo-Cytoplasmic Redistribution of Splicing Factors to Regulate Alternative Pre-mRNA Splicing.
Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections.
Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection.
Rhinovirus 16 2A Protease Affects Nuclear Localization of 3CD during Infection.
RHINOVIRUS 3C PROTEASE CAN LOCALISE IN THE NUCLEUS AND ALTER ACTIVE AND PASSIVE NUCLEOCYTOPLASMIC TRANSPORT.
The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase.
The mammalian host protein DAP5 facilitates the initial round of translation of Coxsackievirus B3 RNA.
The predominant elF4G-specific cleavage activity in poliovirus-infected HeLa cells is distinct from 2A protease.
Toll-Like Receptor 3 Is Involved in Detection of Enterovirus A71 Infection and Targeted by Viral 2A Protease.
Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene.
Ubiquitin-like protein ISG15 (interferon-stimulated gene of 15 kDa) in host defense against heart failure in a mouse model of virus-induced cardiomyopathy.
Use of fluorescence resonance energy transfer for rapid detection of enteroviral infection in vivo.
Viral proteinase requirements for the nucleocytoplasmic relocalization of cellular splicing factor SRp20 during picornavirus infections.
Visualizing and quantifying the differential cleavages of the eukaryotic translation initiation factors eIF4GI and eIF4GII in the enterovirus-infected cell.
[The 2A protease of enterovirus 71 cleaves nup62 to inhibit nuclear transport].
Influenza, Human
Reverse genetic engineering of the human rhinovirus serotype 16 genome to introduce an antibody-detectable tag.
Lung Neoplasms
The ubiquitin-specific protease USP2a prevents endocytosis-mediated EGFR degradation.
Meningitis, Aseptic
Essential Role of Enterovirus 2A Protease in Counteracting Stress Granule Formation and the Induction of Type I Interferon.
Mouth Diseases
Crystal Structure of 2A Proteinase from Hand, Foot and Mouth Disease Virus.
Myelitis
Enterovirus D68 Protease 2Apro Targets TRAF3 To Subvert Host Innate Immune Responses.
Validating Enterovirus D68-2Apro as an Antiviral Drug Target and the Discovery of Telaprevir as a Potent D68-2Apro Inhibitor.
Myocarditis
Essential Role of Enterovirus 2A Protease in Counteracting Stress Granule Formation and the Induction of Type I Interferon.
Homology modeling, docking, molecular dynamics simulation, and structural analyses of coxsakievirus B3 2A protease: An enzyme involved in the pathogenesis of inflammatory myocarditis.
Neoplasm Metastasis
Decreased USP2a Expression Inhibits Trophoblast Invasion and Associates With Recurrent Miscarriage.
USP2a Supports Metastasis by Tuning TGF-? Signaling.
Neoplasms
Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas.
Decreased USP2a Expression Inhibits Trophoblast Invasion and Associates With Recurrent Miscarriage.
Identification of small-molecule inhibitors of USP2a.
Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G
MdmX is a substrate for the deubiquitinating enzyme USP2a.
MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer.
Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas.
The Isopeptidase USP2a Protects Human Prostate Cancer from Apoptosis.
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer.
The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer.
Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma.
USP2a Supports Metastasis by Tuning TGF-? Signaling.
Paralysis
Essential Role of Enterovirus 2A Protease in Counteracting Stress Granule Formation and the Induction of Type I Interferon.
Translation driven by picornavirus IRES is hampered from Sindbis virus replicons: rescue by poliovirus 2A protease.
Picornaviridae Infections
Relationship of p220 cleavage during picornavirus infection to 2A proteinase sequencing.
Pneumonia
Human rhinovirus proteinase 2A induces T(H)1 and T(H)2 immunity in patients with chronic obstructive pulmonary disease.
Poliomyelitis
Identification of two determinants that attenuate vaccine-related type 2 poliovirus.
Interference with vaccinia virus growth caused by insertion of the coding sequence for poliovirus protease 2A.
Structure-Function Mutational Analysis and Prediction of the Potential Impact of High Risk Non-Synonymous Single-Nucleotide Polymorphism on Poliovirus 2A Protease Stability Using Comprehensive Informatics Approaches.
[Insertional mutagenesis of protease 2A of the poliomyelitis virus and its substrate, simultaneously expressed in Escherichia coli cells]
Prostatic Neoplasms
Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas.
MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer.
The Isopeptidase USP2a Protects Human Prostate Cancer from Apoptosis.
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer.
The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer.
USP2a activation of MYC in prostate cancer.
Pulmonary Disease, Chronic Obstructive
Human rhinovirus proteinase 2A induces T(H)1 and T(H)2 immunity in patients with chronic obstructive pulmonary disease.
Respiratory Tract Infections
Enterovirus D68 Protease 2Apro Targets TRAF3 To Subvert Host Innate Immune Responses.
Human rhinovirus proteinase 2A induces T(H)1 and T(H)2 immunity in patients with chronic obstructive pulmonary disease.
Squamous Cell Carcinoma of Head and Neck
Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas.
Swine Vesicular Disease
An attenuating mutation in the 2A protease of swine vesicular disease virus, a picornavirus, regulates cap- and internal ribosome entry site-dependent protein synthesis.
Importance of arginine 20 of the swine vesicular disease virus 2A protease for activity and virulence.
Significance of arginine 20 in the 2A protease for swine vesicular disease virus pathogenicity.
Virulence of swine vesicular disease virus is determined at two amino acids in capsid protein VP1 and 2A protease.
Urinary Bladder Neoplasms
Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis.
The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer.
Vaccinia
A poliovirus minireplicon containing an inactive 2A proteinase is expressed in vaccinia virus-infected cells.
Efficient cleavage of p220 by poliovirus 2Apro expression in mammalian cells: effects on vaccinia virus.
Encapsidation and serial passage of a poliovirus replicon which expresses an inactive 2A proteinase.
Expression of poliovirus 2Apro in mammalian cells: effects on translation.
Interference with vaccinia virus growth caused by insertion of the coding sequence for poliovirus protease 2A.
Limited expression of poliovirus by vaccinia virus recombinants due to inhibition of the vector by proteinase 2A.
Mutational analysis of poliovirus 2Apro. Distinct inhibitory functions of 2apro on translation and transcription.
Translation of mRNAs from Vesicular Stomatitis Virus and Vaccinia Virus Is Differentially Blocked in Cells with Depletion of eIF4GI and/or eIF4GII.
Vesicular Stomatitis
Expression of poliovirus 2Apro in mammalian cells: effects on translation.
Poliovirus protease 2A is required for interference with vesicular stomatitis virus-specified protein synthesis.
Translation of mRNAs from Vesicular Stomatitis Virus and Vaccinia Virus Is Differentially Blocked in Cells with Depletion of eIF4GI and/or eIF4GII.
Virus Diseases
Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy.
Multiple eIF4GI-specific protease activities present in uninfected and poliovirus-infected cells.
Validating Enterovirus D68-2Apro as an Antiviral Drug Target and the Discovery of Telaprevir as a Potent D68-2Apro Inhibitor.
Yellow Fever
[Construction of recombinant yellow fever virus 17D containing 2A fragment as a vaccine vector]