Reference on EC 3.4.22.2 - papain
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vartak, H.G.; Rele, M.V.; Jagannathan, V.
Proteinase inhibitors from Vigna unguiculata subsp. cylindrica. III. Properties and kinetics of inhibitors of papain, subtilisin, and trypsin
Arch. Biochem. Biophys.
204
134-140
1980
Carica papaya
Dubois, T.; Jacquet, A.; Schnek, A.G.; Looze, Y.
The thiol proteinases from the latex of Carica papaya L. I. Fractionation, purification and preliminary characterization
Biol. Chem. Hoppe-Seyler
369
733-740
1988
Carica papaya
Glazer, A.N.; Smith, E.L.
Papain and other plant sulfhydryl proteolytic enzymes
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
3
501-546
1971
Carica papaya
-
Saito, M.; Kawaguchi, N.; Hashimoto, M.; Kodama, T.; Higuchi, N.; Tanaka, T.; Nomoto, K.; Murachi, T.
Purification and structure of novel cysteine proteinase inhibitors, staccopins P1 and P2, from Staphylococcus tanabeensis
Agric. Biol. Chem.
51
861-868
1987
Carica papaya
-
Abe, K.; Emori, Y.; Kondo, H.; Arai, S.; Suzuki, K.
The NH2-terminal 21 amino acid residues are not essential for the papain-inhibitory activity of oryzacystatin, a member of the cystatin superfamily. Expression of oryzacystatin cDNA and its truncated fragments in Escherichia coli
J. Biol. Chem.
263
7655-7659
1988
Carica papaya
Groeger, U.; Stehle, P.; Furst, P.; Leuchtenberger, W.; Drauz, K.
Papain-catalyzed synthesis of dipeptides
Food Biotechnol.
2
187-198
1989
Carica papaya
-
Cohen, L.W.; Coghlan, V.M.; Dihel, L.C.
Cloning and sequencing of papain-encoding cDNA
Gene
48
219-227
1986
Carica papaya
Chiou, R.Y.Y.; Beuchat, L.R.
Characteristics and application of immobilized papain in a continuous-flow reactor
Biotechnol. Appl. Biochem.
8
529-536
1986
Carica papaya
Storer, A.; Carey, P.R.
Comparison of the kinetics and mechanism of the papain-catalyzed hydrolysis of esters and thiono esters
Biochemistry
24
6808-6818
1985
Carica papaya
Syu, W.J.; Wu, S.H.; Wang, K.T.
Purification of papain by affinity chromatography
J. Chromatogr.
262
346-351
1983
Carica papaya
Kilara, A.; Shahani, K.M.; Wagner, F.W.
Preparation and properties of immobilized papain and lipase
Biotechnol. Bioeng.
14
1703-1714
1977
Carica papaya
-
Messing, R.A.
Insoluble papain prepared by adsorption on porous glass
Enzymologia
38
39-42
1970
Carica papaya
Burke, D.E.; Lewis, S.D.; Shafer, J.A.
A two-step procedure for purification of papain from extract of papaya latex
Arch. Biochem. Biophys.
164
30-36
1974
Carica papaya
Drenth, J.; Jansonius, J.N.; Koekoek, R.; Wolters, B.G.
Papain, X-ray structure
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
3
485-499
1971
Carica papaya
-
Skelton, G.S.
Papaya proteinases. III. Effect of activators on the hydrolysis of benzoyl argininamide
Enzymologia
35
279-282
1968
Carica papaya
Matsumoto, K.; Murata, M.; Sumiya, S.; Mizoue, K.; Kitamura, K.; Ishida, T.
X-ray crystal structure of papain complexed with cathepsin B-specific covalent-type inhibitor: substrate specificity and inhibitory activity
Biochim. Biophys. Acta
1383
93-100
1998
Carica papaya
Sueyoshi, T.; Enjyoji, K.; Shimada, T.; Kato, H.; Iwanaga, S.; Bando, Y.; Kominami, E.; Katunuma, N.
A new function of kininogens as thiol-proteinase inhibitors: inhibition of papain and cathepsins B, H and L by bovine, rat and human plasma kininogens
FEBS Lett.
182
193-195
1985
Carica papaya
Mitchell, R.E.J.; Chaiken, I.M.; Smith, E.L.
The complete amino acid sequence of papain. Additions and corrections
J. Biol. Chem.
245
3485-3492
1970
Carica papaya
Blumberg, S.; Schechter, I.; Berger, A.
The purification of papain by affinity chromatography
Eur. J. Biochem.
15
97-102
1970
Carica papaya
Fink, A.L.; Bender, M.L.
Binding sites for substrate leaving groups and added nucleophiles in papain-catalyzed hydrolyses
Biochemistry
8
5109-5118
1969
Carica papaya
Menard, R.; Storer, A.C.
Papain
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
555-557
1998
Carica papaya
-
Skelton, G.S.
Papaya proteinases. I. Temperature-and pH-stability curves
Enzymologia
35
270-274
1968
Carica papaya
Skelton, G.S.
Papaya proteinases. II. Effect of ascorbic acid on proteolytic activity
Enzymologia
35
275-278
1968
Carica papaya
Sluyterman, L.A.AE.
Product inhibition of papain action
Biochim. Biophys. Acta
85
316-321
1964
Carica papaya
Sluyterman, L.A.AE.
Kinetics of the hydrolysis of benzoylglycine ethyl ester catalyzed by papain
Biochim. Biophys. Acta
85
305-315
1964
Carica papaya
Baker, E.; Drenth, J.
The thiol proteases: structure and mechanism
Biological Macromolecules and Assemblies (Junak, F. McPherson eds. )
3
313-368
1987
Carica papaya
-
Smyth, D.G.
Use of papain, pepsin, and subtilisin in sequence determination
Methods Enzymol.
11
421-426
1967
Carica papaya
-
Schrder, E.; Phillips, C.; Garman, E.; Harlos, K.; Crawford, C.
X-ray crystallographic structure of a papain-leupeptin complex
FEBS Lett.
315
38-42
1993
Carica papaya
Carty, R.P.; Kirschenbaum, D.M.
The papain-catalyzed synthesis of hippuryl anilide
Biochim. Biophys. Acta
85
446-461
1964
Carica papaya
Kim, M.J.; Yamamoto, D.; Matsumoto, K.; Inoue, M.; Ishida, T.; Mizuno, H.; Sumiya, S.; Kitamura, K.
Crystal structure of papain-E64-c complex. Binding diversity of E64-c to papain S2 and S3 subsites
Biochem. J.
287
797-803
1992
Carica papaya
Stubbs, M.T.; Laber, B.; Bode, W.; Huber, R.; Jerala, R.; Lenaricic, B.; Turk, V.
The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction
EMBO J.
9
1939-1947
1990
Carica papaya
Mekkes, J.R.; le Poole, I.C.; Das, P.K.; Kammeyer, A.; Westerhof, W.
In vitro tissue-digesting properties of krill enzymes compared with fibrinolysin/DNAse, papain and placebo
Int. J. Biochem. Cell Biol.
29
703-706
1997
Carica papaya
Yamamoto, A.; Tomoo, K.; Doi, M.; Ohishi, H.; Inoue, M.; Ishida, T.; Yamamoto, D.; Tsuboi, S.; Okamoto, H.; Okada, Y.
Crystal structure of papain-succinyl-Gln-Val-Val-Ala-Ala-p-nitroanilide complex at 1.7-A resolution: noncovalent binding mode of a common sequence of endogenous thiol protease inhibitors
Biochemistry
31
11305-11309
1992
Carica papaya
Yamamoto, D.; Ishida, T.; Inoue, M.
A comparison between the binding modes of a substrate and inhibitor to papain as observed in complex crystal structures
Biochem. Biophys. Res. Commun.
171
711-716
1990
Carica papaya
Menard, R.; Khouri, H.E.; Plouffe, C.; Dupras, R.; Ripoll, D.; Vernet, T.; Tessier, D.C.; Laliberte, F.; Thomas, D.Y.; Storer, A.C.
A protein engineering study of the role of aspartate 158 in the catalytic mechanism of papain
Biochemistry
29
6706-6713
1990
Carica papaya
Khouri, H.E.; Vernet, T.; Menard, R.; Parlati, F.; Laflamme, P.; Tessier, D.C.; Gour-Salin, B.; Thomas, D.Y.; Storer, A.C.
Engineering of papain
Biochemistry
30
8929-8936
1991
Carica papaya
Matsumoto, K.; Murata, M.; Sumiya, S.; Kitamura, K.; Ishida, T.
Clarification of substrate specificity of papain by crystal analyses of complexes with covalent-type inhibitors
Biochim. Biophys. Acta
1208
268-276
1994
Carica papaya
Kozak, M.; Kozian, E.; Gronka, Z.; Jaskolski, M.
Crystallization and preliminary crystallographic studies of a new form of papain from Carica papaya
Acta Biochim. Pol.
44
601-606
1997
Carica papaya
LaLonde, J.M.; Zhao, B.; Smith, W.W.; Janson, C.A.; DesJarlais, R.I.; Tomaszek, T.A.; Carr, T.J.; Thompson, S.K.; Oh, H.; Yamashita, D.N.; Veber, D.F.; Abdel-Meguid, S.S.
Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites
J. Med. Chem.
41
4567-4576
1998
Carica papaya
Inman, F.P.; Hazen, S.R.
Characterization of a large fragment produced by proteolysis of human immunoglobulin M with papain
J. Biol. Chem.
243
5598-5604
1968
Carica papaya
Brocklehurst, K.; Carlsson, J.; Kierstan, M.P.J.; Crok, E.M.
Covalent chromatography by thiol-disulfide interchange
Methods Enzymol.
34B
532-544
1974
Carica papaya
-
Brocklehurst, K.; Carlsson, J.; Kierstan, M.P.J.; Crook, E.M.
Covalent chromatography. Preparation of fully active papain from dried papaya latex
Biochem. J.
133
573-584
1973
Carica papaya
Brocklehurst, K.; Baines, B.S.; Kierstan, M.P.J.
Papain and other constituents of Carica papaya L
Top. Enzyme Ferment. Biotechnol.
5
262-335
1981
Carica papaya
-
Kennedy, J.F.; Pike, V.W.
Papain, chymotrypsin and related proteins - a comparative study of their beer chill-proofing abilities and characteristics
Enzyme Microb. Technol.
3
59-63
1981
Carica papaya
-
Abernethy, J.L.; Lovett, C.M.; Haddad, A.; Felberg, J.D.
Stereoselective action of acylated crude papain toward mandelic and atrolactic hydrazides
Bioorg. Chem.
11
251-261
1982
Carica papaya
-
Szabelski, M.; Stachowiak, K.; Wiczk, W.
Influence of organic solvents on papain kinetics
Acta Biochim. Pol.
48
1197-1201
2001
Carica papaya
Szabelski, M.; Stachowiak, K.; Wiczk, W.
Influence of Me2SO and incubation time on papain activity studied using fluorogenic substrates
Acta Biochim. Pol.
48
995-1002
2001
Carica papaya
Tseng, C.C.; Tseng, C.P.; Levine, M.J.; Bobek, L.A.
Differential effect toward inhibition of papain and cathepsin C by recombinant human salivary cystatin SN and its variants produced by a baculovirus system
Arch. Biochem. Biophys.
380
133-140
2000
Carica papaya
Achilles, K.; Schirmeister, T.; Otto, H.H.
beta-Lactam derivatives as enzyme inhibitors: 1-peptidyl derivatives of 4-phenylazetidin-2-one as inhibitors of elastase and papain
Arch. Pharm.
333
243-253
2000
Carica papaya
Edwin, F.; Sharma, Y.V.; Jagannadham, M.V.
Stabilization of molten globule state of papain by urea
Biochem. Biophys. Res. Commun.
290
1441-1446
2002
Carica papaya
Lowther, J.; Djurdjevic-Pahl, A.; Hewage, C.; Malthouse, J.P.
A 13C-NMR study of the inhibition of papain by a dipeptide-glyoxal inhibitor
Biochem. J.
366
983-987
2002
Carica papaya
Theodorou, L.G.; Lymperopoulos, K.; Bieth, J.G.; Papamichael, E.M.
Insight into the catalysis of hydrolysis of four newly synthesized substrates by papain: a proton inventory study
Biochemistry
40
3996-4004
2001
Carica papaya
Hwang, S.R.; Steineckert, B.; Toneff, T.; Bundey, R.; Logvinova, A.V.; Goldsmith, P.; Hook, V.Y.
The novel serpin endopin 2 demonstrates cross-class inhibition of papain and elastase: localization of endopin 2 to regulated secretory vesicles of neuroendocrine chromaffin cells
Biochemistry
41
10397-10405
2002
Carica papaya
Edwin, F.; Jagannadham, M.V.
Single disulfide bond reduced papain exists in a compact intermediate state
Biochim. Biophys. Acta
1479
69-82
2000
Carica papaya
Xian, M.; Chen, X.; Liu, Z.; Wang, K.; Wang, P.G.
Inhibition of papain by S-nitrosothiols. Formation of mixed disulfides
J. Biol. Chem.
275
20467-20473
2000
Carica papaya
Ghosh, K.; Chattopadhyaya, R.
Papain does not cleave operator-bound lambda repressor: structural characterization of the carboxy terminal domain and the hinge
J. Biomol. Struct. Dyn.
18
557-567
2001
Carica papaya
Luo, Q.; Mao, X.; Kong, L.; Huang, X.; Zou, H.
High-performance affinity chromatography for characterization of human immunoglobulin G digestion with papain
J. Chromatogr. B
776
139-147
2002
Carica papaya
Golan, R.; Zehavi, U.; Naim, M.; Patchornik, A.; Smirnoff, P.; Herchman, M.
Inhibition of Papaya latex papain by photosensitive inhibitors. 1-(4,5-dimethoxy-2-nitrophenyl)-2-nitroethene and 1,1-dicyano-2-(4,5-dimethoxy-2-nitrophenyl)-ethene
J. Protein Chem.
19
117-122
2000
Carica papaya
Kaul, P.; Sathish, H.A.; Prakash, V.
Effect of metal ions on structure and activity of papain from Carica papaya
Nahrung
46
2-6
2002
Carica papaya
Achilles, K.; Schneider, M.; Schirmeister, T.; Otto, H.H.
beta-Lactam derivatives as enzyme inhibitors: N-substituted derivatives of (S)-4-oxoazetidine-2-carboxylate as inhibitors of elastase and papain
Pharmazie
55
798-802
2000
Carica papaya
Sharma, Y.V.; Jagannadham, M.V.
N-terminal domain unfolds first in the sequential unfolding of papain
Protein Pept. Lett.
10
83-90
2003
Carica papaya
Franco, O.L.; Grossi de Sa, M.F.; Sales, M.P.; Mello, L.V.; Oliveira, A.S.; Rigden, D.J.
Overlapping binding sites for trypsin and papain on a Kunitz-type proteinase inhibitor from Prosopis juliflora
Proteins Struct. Funct. Genet.
49
335-341
2002
Carica papaya
Naeem, A.; Khan, K.A.; Khan, R.H.
Characterization of a partially folded intermediate of papain induced by fluorinated alcohols at low pH
Arch. Biochem. Biophys.
432
79-87
2004
Carica papaya
Gutierrez-Gonzalez, L.H.; Rojo-Dominguez, A.; Cabrera-Gonzalez, N.E.; Perez-Montfort, R.; Padilla-Zuniga, A.J.
Loosely packed papain prosegment displays inhibitory activity
Arch. Biochem. Biophys.
446
151-160
2006
Carica papaya (P00784)
Bratkovic, T.; Lunder, M.; Popovic, T.; Kreft, S.; Turk, B.; Strukelj, B.; Urleb, U.
Affinity selection to papain yields potent peptide inhibitors of cathepsins L, B, H, and K
Biochem. Biophys. Res. Commun.
332
897-903
2005
Carica papaya
Vishu Kumar, A.B.; Varadaraj, M.C.; Gowda, L.R.; Tharanathan, R.N.
Characterization of chito-oligosaccharides prepared by chitosanolysis with the aid of papain and pronase, and their bactericidal action against Bacillus cereus and Escherichia coli
Biochem. J.
391
167-175
2005
Carica papaya
Gul, S.; Mellor, G.W.; Thomas, E.W.; Brocklehurst, K.
Temperature-dependences of the kinetics of reactions of papain and actinidin with a series of reactivity probes differing in key molecular recognition features
Biochem. J.
396
17-21
2006
Carica papaya
Valente, C.; Guedes, R.C.; Moreira, R.; Iley, J.; Gut, J.; Rosenthal, P.J.
Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum
Bioorg. Med. Chem. Lett.
16
4115-4119
2006
Carica papaya
Theppakorn, T.; Kanasawud, P.; Halling, P.J.
Activity of immobilized papain dehydrated by n-propanol in low-water media
Biotechnol. Lett.
26
133-136
2004
Carica papaya
Lei, H.; Wang, W.; Chen, L.; Li, X.; Yi, B.; Deng, L.
The preparation and catalytically active characterization of papain immobilized on magnetic composite microspheres
Enzyme Microb. Technol.
35
15-21
2004
Carica papaya
-
Konno, K.; Hirayama, C.; Nakamura, M.; Tateishi, K.; Tamura, Y.; Hattori, M.; Kohno, K.
Papain protects papaya tress from herbivorous insects: role of cysteine proteases in latex
Plant J.
37
370-374
2004
Carica papaya
Alphey, M.S.; Hunter, W.N.
High-resolution complex of papain with remnants of a cysteine protease inhibitor derived from Trypanosoma brucei
Acta Crystallogr. Sect. F
F62
504-508
2006
Carica papaya
Gul, S.; Hussain, S.; Thomas, M.P.; Resmini, M.; Verma, C.S.; Thomas, E.W.; Brocklehurst, K.
Generation of nucleophilic character in the Cys25/His159 ion pair of papain involves Trp177 but not Asp158
Biochemistry
47
2025-2035
2008
Carica papaya
Narai-Kanayama, A.; Koshino, H.; Aso, K.
Mass spectrometric and kinetic studies on slow progression of papain-catalyzed polymerization of L-glutamic acid diethyl ester
Biochim. Biophys. Acta
1780
881-891
2008
Carica papaya
Naeem, A.; Fatima, S.; Khan, R.H.
Characterization of partially folded intermediates of papain in presence of cationic, anionic, and nonionic detergents at low pH
Biopolymers
83
1-10
2006
Carica papaya
Theodorou, L.G.; Bieth, J.G.; Papamichael, E.M.
The catalytic mode of cysteine proteinases of papain (C1) family
Biores. Technol.
98
1931-1939
2007
Carica papaya
Haquette, P.; Salmain, M.; Svedlung, K.; Martel, A.; Rudolf, B.; Zakrzewski, J.; Cordier, S.; Roisnel, T.; Fosse, C.; Jaouen, G.
Cysteine-specific, covalent anchoring of transition organometallic complexes to the protein papain from Carica papaya
ChemBioChem
8
224-231
2007
Carica papaya
Martinez, M.; Diaz-Mendoza, M.; Carrillo, L.; Diaz, I.
Carboxy terminal extended phytocystatins are bifunctional inhibitors of papain and legumain cysteine proteinases
FEBS Lett.
581
2914-2918
2007
Carica papaya
Sathish, H.A.; Kumar, P.R.; Prakash, V.
Mechanism of solvent induced thermal stabilization of papain
Int. J. Biol. Macromol.
41
383-390
2007
Carica papaya
Hatori, Y.; Majima, E.; Tsuda, T.; Toyoshima, C.
Domain organization and movements in heavy metal ion pumps: papain digestion of CopA, a Cu+-transporting ATPase
J. Biol. Chem.
282
25213-25221
2007
Carica papaya
Sangeetha, K.; Abraham, T.E.
Chemical modification of papain for use in alkaline medium
J. Mol. Catal. B
38
171-177
2006
Carica papaya
-
Li, G.; Vaidya, A.; Viswanathan, K.; Cui, J.; Xie, W.; Gao, W.; Gross, R.A.
Rapid regioselective oligomerization of L-glutamic acid diethyl ester catalyzed by papain
Macromolecules
39
7915-7921
2006
Carica papaya
-
Grabovac, V.; Schmitz, T.; Foeger, F.; Bernkop-Schnuerch, A.
Papain: an effective permeation enhancer for orally administered low molecular weight heparin
Pharm. Res.
24
1001-1006
2007
Carica papaya
Shabab, M.; Kulkarni, M.J.; Khan, M.I.
Study of papain-cystatin interaction by intensity fading MALDI-TOF-MS
Protein J.
27
7-12
2008
Carica papaya
Lang, A.; Hatscher, C.; Kuhl, P.
Papain-catalyzed synthesis of Z-L-aminoacyl-antipyrine amides from Z-protected amino acid esters and 4-aminoantipyrine
Tetrahedron Lett.
48
3371-3374
2007
Carica papaya (P00784)
-
Cornell, H.J.; Doherty, W.; Stelmasiak, T.
Papaya latex enzymes capable of detoxification of gliadin
Amino Acids
38
155-165
2009
Carica papaya
Diaz-Mochon, J.J.; Planonth, S.; Bradley, M.
From 10,000 to 1: Selective synthesis and enzymatic evaluation of fluorescence resonance energy transfer peptides as specific substrates for chymopapain
Anal. Biochem.
384
101-105
2009
Carica papaya
Xue, Y.; Nie, H.; Zhu, L.; Li, S.; Zhang, H.
Immobilization of Modified Papain with Anhydride Groups on Activated Cotton Fabric
Appl. Biochem. Biotechnol.
160
109-121
2009
Carica papaya, Carica papaya (P00784)
Su, S.N.; Nie, H.L.; Zhu, L.M.; Chen, T.X.
Optimization of adsorption conditions of papain on dye affinity membrane using response surface methodology
Biores. Technol.
100
2336-2340
2009
Carica papaya
Redzynia, I.; Ljunggren, A.; Bujacz, A.; Abrahamson, M.; Jaskolski, M.; Bujacz, G.
Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases
FEBS J.
276
793-806
2009
Carica papaya (P00784)
Choudhury, D.; Roy, S.; Chakrabarti, C.; Biswas, S.; Dattagupta, J.K.
Production and recovery of recombinant propapain with high yield
Phytochemistry
70
465-472
2009
Carica papaya (P00784)
Homaei, A.A.; Sajedi, R.H.; Sariri, R.; Seyfzadeh, S.; Stevanato, R.
Cysteine enhances activity and stability of immobilized papain
Amino Acids
38
937-942
2010
Carica papaya
Chen, C.X.; Jiang, B.; Branford-White, C.; Zhu, L.M.
Enantioselective reductive amination of alpha-keto acids by papain-based semisynthetic enzyme
Biochemistry (Moscow)
74
36-40
2009
Carica papaya
Chen, T.X.; Nie, H.L.; Li, S.B.; Branford-White, C.; Su, S.N.; Zhu, L.M.
Comparison: adsorption of papain using immobilized dye ligands on affinity membranes
Colloids Surf. B Biointerfaces
72
25-31
2009
Carica papaya
Zhang, Y.; Shi, G.; Zhao, F.
Hydrolysis of casein catalyzed by papain in n-propanol/NaCl two-phase system
Enzyme Microb. Technol.
46
438-443
2010
Carica papaya
Li, S.; Tang, Y.
Accurate determination of internalization for target binding antibody using papain digestion and flow cytometry
Hybridoma
29
133-139
2010
Carica papaya
Andrade, L.B.; Oliveira, A.S.; Ribeiro, J.K.; Kiyota, S.; Vasconcelos, I.M.; de Oliveira, J.T.; de Sales, M.P.
Effects of a novel pathogenesis-related class 10 (PR-10) protein from Crotalaria pallida roots with papain inhibitory activity against root-knot nematode Meloidogyne incognita
J. Agric. Food Chem.
58
4145-4152
2010
Carica papaya
Kempson, I.M.; Barnes, T.J.; Prestidge, C.A.
Use of TOF-SIMS to study adsorption and loading behavior of methylene blue and papain in a nano-porous silicon layer
J. Am. Soc. Mass Spectrom.
21
254-260
2010
Carica papaya
da Silva, C.R.; Oliveira, M.B.; Motta, E.S.; de Almeida, G.S.; Varanda, L.L.; de Padula, M.; Leitao, A.C.; Caldeira-de-Araujo, A.
Genotoxic and cytotoxic safety evaluation of papain (Carica papaya L.) using in vitro assays
J. Biomed. Biotechnol.
2010
197898
2010
Carica papaya
Szabo, A.; Kotorman, M.; Laczko, I.; Simon, L.
Influence of carbohydrates on stability of papain in aqueous tetrahydrofuran mixture
J. Chem. Technol. Biotechnol.
84
133-138
2009
Carica papaya
-
Jeong, J.; Hur, W.
Even-numbered peptides from a papain hydrolysate of silk fibroin
J. Chromatogr.
878
836-840
2010
Carica papaya
Mehta, S.K.; Bhawna, S.K.; Ram, G.
Behavior of papain in mixed micelles of anionic-cationic surfactants having similar tails and dissimilar head groups
J. Colloid Interface Sci.
344
105-111
2010
Carica papaya
Rudolf, B.; Salmain, M.; Martel, A.; Palusiak, M.; Zakrzewski, J.
eta(1)-N-succinimidato complexes of iron, molybdenum and tungsten as reversible inhibitors of papain
J. Inorg. Biochem.
103
1162-1168
2009
Carica papaya
Hyono, A.; Gaboriaud, F.; Mazda, T.; Takata, Y.; Ohshima, H.; Duval, J.F.
Impacts of papain and neuraminidase enzyme treatment on electrohydrodynamics and IgG-mediated agglutination of type A red blood cells
Langmuir
25
10873-10885
2009
Carica papaya
Panicker, S.; Borgia, J.; Fhied, C.; Mikecz, K.; Oegema, T.R.
Oral glucosamine modulates the response of the liver and lymphocytes of the mesenteric lymph nodes in a papain-induced model of joint damage and repair
Osteoarthritis Cartilage
17
1014-1021
2009
Carica papaya
Choudhury, D.; Biswas, S.; Roy, S.; Dattagupta, J.K.
Improving thermostability of papain through structure-based protein engineering
Protein Eng. Des. Sel.
23
457-467
2010
Carica papaya
Zhao, Y.; Gutshall, L.; Jiang, H.; Baker, A.; Beil, E.; Obmolova, G.; Carton, J.; Taudte, S.; Amegadzie, B.
Two routes for production and purification of Fab fragments in biopharmaceutical discovery research: Papain digestion of mAb and transient expression in mammalian cells
Protein Expr. Purif.
67
182-189
2009
Carica papaya
Oliveira, A.S.; Migliolo, L.; Aquino, R.O.; Ribeiro, J.K.; Macedo, L.L.; Bemquerer, M.P.; Santos, E.A.; Kiyota, S.; de Sales, M.P.
Two Kunitz-type inhibitors with activity against trypsin and papain from Pithecellobium dumosum seeds: purification, characterization, and activity towards pest insect digestive enzyme
Protein Pept. Lett.
16
1526-1532
2009
Carica papaya
Shokhen, M.; Khazanov, N.; Albeck, A.
Challenging a paradigm: Theoretical calculations of the protonation state of the Cys25-His159 catalytic diad in free papain
Proteins Struct. Funct. Bioinform.
77
916-926
2009
Carica papaya
Zulli, G.; Lopes, P.; Velasco, M.; Alcantara, M.; Rogero, S.; Lugao, A.; Mathor, M.
Influence of gamma radiation onto polymeric matrix with papain
Radiat. Phys. Chem.
79
286-288
2010
Carica papaya
-
Hu, W.; Guan, Z.; Deng, X.; He, Y.H.
Enzyme catalytic promiscuity: The papain-catalyzed Knoevenagel reaction
Biochimie
94
656-661
2012
Carica papaya
de Beer, R.J.; Zarzycka, B.; Amatdjais-Groenen, H.I.; Jans, S.C.; Nuijens, T.; Quaedflieg, P.J.; van Delft, F.L.; Nabuurs, S.B.; Rutjes, F.P.
Papain-catalyzed peptide bond formation: enzyme-specific activation with guanidinophenyl esters
ChemBioChem
12
2201-2207
2011
Carica papaya
Chu, M.H.; Liu, K.L.; Wu, H.Y.; Yeh, K.W.; Cheng, Y.S.
Crystal structure of tarocystatin-papain complex: implications for the inhibition property of group-2 phytocystatins
Planta
234
243-254
2011
Carica papaya (P00784)
Li, M.; Su, E.; You, P.; Gong, X.; Sun, M.; Xu, D.; Wei, D.
Purification and in situ immobilization of papain with aqueous two-phase system
PLoS ONE
5
e15168
2010
Carica papaya
Llerena-Suster, C.; Jose, C.; Collins, S.; Briand, L.; Morcelle, S.
Investigation of the structure and proteolytic activity of papain inaqueous miscible organic media
Process Biochem.
47
47-56
2012
Carica papaya
-
Shokhen, M.; Khazanov, N.; Albeck, A.
The mechanism of papain inhibition by peptidyl aldehydes
Proteins
79
975-985
2011
Carica papaya (P00784)
Homaei, A.; Barkheh, H.; Sariri, R.; Stevanato, R.
Immobilized papain on gold nanorods as heterogeneous biocatalysts
Amino Acids
46
1649-1657
2014
Carica papaya
Kim, C.J.; Lee, D.I.; Lee, C.H.; Ahn, I.S.
A dityrosine-based substrate for a protease assay: application for the selective assessment of papain and chymopapain activity
Anal. Chim. Acta
723
101-107
2012
Carica papaya
Uygun, D.A.; Akduman, B.; Uygun, M.; Akgoel, S.; Denizli, A.
Purification of papain using reactive green 5 attached supermacroporous monolithic cryogel
Appl. Biochem. Biotechnol.
167
552-563
2012
Carica papaya
Fan, Y.; Yan, J.; Zhang, S.; Li, J.; Chen, D.; Duan, P.
Fluorescence spectroscopic analysis of the interaction of papain with ionic liquids
Appl. Biochem. Biotechnol.
168
592-603
2012
Carica papaya
Chalabi, M.; Khademi, F.; Yarani, R.; Mostafaie, A.
Proteolytic activities of kiwifruit actinidin (Actinidia deliciosa cv. Hayward) on different fibrous and globular proteins: a comparative study of actinidin with papain
Appl. Biochem. Biotechnol.
172
4025-4037
2014
Carica papaya
Chou, Y.W.; Cheng, S.C.; Lai, H.Y.; Chou, C.Y.
Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease
Arch. Biochem. Biophys.
520
74-80
2012
Alphacoronavirus
Wei, D.; Huang, X.; Liu, J.; Tang, M.; Zhan, C.G.
Reaction pathway and free energy profile for papain-catalyzed hydrolysis of N-acetyl-Phe-Gly 4-nitroanilide
Biochemistry
52
5145-5154
2013
Carica papaya
Rudakova, A.S.; Rudakov, S.V.; Kakhovskaya, I.A.; Shutov, A.D.
11S Storage globulin from pumpkin seeds: regularities of proteolysis by papain
Biochemistry
79
820-825
2014
Carica papaya
Mohr, T.; Desser, L.
Plant proteolytic enzyme papain abrogates angiogenic activation of human umbilical vein endothelial cells (HUVEC) in vitro
BMC Complement. Altern. Med.
13
231
2013
Carica papaya
Esti, M.; Benucci, I.; Lombardelli, C.; Liburdi, K.; Garzillo, A.
Papain from papaya (Carica papaya L.) fruit and latex: Preliminary characterization in alcoholic-acidic buffer for wine application
Food Bioprod. Process.
91
595-598
2013
Carica papaya
Alpay, P.; Uygun, D.
Usage of immobilized papain for enzymatic hydrolysis of proteins
J. Mol. Catal. B
111
56-63
2015
Carica papaya
-
Richau, K.H.; Kaschani, F.; Verdoes, M.; Pansuriya, T.C.; Niessen, S.; Stueber, K.; Colby, T.; Overkleeft, H.S.; Bogyo, M.; Van der Hoorn, R.A.
Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics
Plant Physiol.
158
1583-1599
2012
Carica papaya
Milosevic, J.; Jankovic, B.; Prodanovic, R.; Polovic, N.
Comparative stability of ficin and papain in acidic conditions and the presence of ethanol
Amino Acids
51
829-838
2019
Carica papaya (P00784)
Mugita, N.; Nambu, T.; Takahashi, K.; Wang, P.L.; Komasa, Y.
Proteases, actinidin, papain and trypsin reduce oral biofilm on the tongue in elderly subjects and in vitro
Arch. Oral Biol.
82
233-240
2017
Carica papaya (P00784)
Lachmanova, S.; Kolivoska, V.; Pospisil, L.; Fanelli, N.; Hromadova, M.
Adsorption of papain on solid substrates of different hydrophobicity
Biointerphases
11
031003
2016
Carica papaya (P00784)
Liu, J.; Sharma, A.; Niewiara, M.; Singh, R.; Ming, R.; Yu, Q.
Papain-like cysteine proteases in Carica papaya lineage-specific gene duplication and expansion
BMC Genomics
19
26
2018
Carica papaya (P00784), Carica papaya
Pan, A.D.; Zeng, H.Y.; Foua, G.B.; Alain, C.; Li, Y.Q.
Enzymolysis of chitosan by papain and its kinetics
Carbohydr. Polym.
135
199-206
2016
Carica papaya (P00784)
Roy, S.; Biswas, S.
Asp72 of pro-peptide is an important pH sensor in the zymogen activation process of papain A structural and mechanistic insight
Curr. Sci.
114
2356-2362
2018
Carica papaya (P00784)
-
Homaei, A.; Samari, F.
Investigation of activity and stability of papain by adsorption on multi-wall carbon nanotubes
Int. J. Biol. Macromol.
105
1630-1635
2017
Carica papaya (P00784)
Homaei, A.
Enhanced activity and stability of papain immobilized on CNBr-activated sepharose
Int. J. Biol. Macromol.
75
373-377
2015
Carica papaya (P00784)
Leichner, C.; Menzel, C.; Laffleur, F.; Bernkop-Schnuerch, A.
Development and in vitro characterization of a papain loaded mucolytic self-emulsifying drug delivery system (SEDDS)
Int. J. Pharm.
530
346-353
2017
Carica papaya (P00784)
Barekat, S.; Soltanizadeh, N.
Application of high-intensity ultrasonic radiation coupled with papain treatment to modify functional properties of beef Longissimus lumborum
J. Food Sci. Technol.
56
224-232
2019
Carica papaya (P00784)
Feng, L.; Cao, Y.; Xu, D.; Zhang, D.; Huang, Z.
Influence of chitosan-sodium alginate pretreated with ultrasound on the enzyme activity, viscosity and structure of papain
J. Sci. Food Agric.
97
1561-1566
2017
Carica papaya (P00784)
Liu, X.; Zeng, H.; Liao, M.; Claude Alain Gohi, B.; Feng, B.
Determination of the kinetics and influence of the mercury ion on papain catalytic activity
RSC Adv.
5
68906-68913
2015
Carica papaya (P00784)
-
Zhang, B.; Li, P.; Zhang, H.; Fan, L.; Wang, H.; Li, X.; Tian, L.; Ali, N.; Ali, Z.; Zhang, Q.
Papain/Zn3(PO4)2 hybrid nanoflower Preparation, characterization and its enhanced catalytic activity as an immobilized enzyme
RSC Adv.
6
46702-46710
2016
Carica papaya (P00784)
-
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