Reference on EC 3.4.22.15 - cathepsin L
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Maciewicz, R.A.; Etherington, D.J.
A comparison of four cathepsins (B, L, N and S) with collagenolytic activity from rabbit spleen
Biochem. J.
256
433-440
1988
Oryctolagus cuniculus
Baricos, W.H.; Zhou, Y.; Mason, R.W.; Barrett, A.J.
Human kidney cathepsins B and L. Characterization and potential role in degradation of glomerular basement membrane
Biochem. J.
252
301-304
1988
Homo sapiens
Reilly, J.J.; Mason, R.W.; Chen, P.; Joseph, L.J.; Sukhatme, V.P.; Yee, R.; Chapman, H.A.
Synthesis and processing of cathepsin L, an elastase, by human alveolar macrophages
Biochem. J.
257
493-498
1989
Homo sapiens
Crawford, C.; Mason, R.W.; Wikstrom, P.; Shaw, E.
The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B
Biochem. J.
253
751-758
1988
Homo sapiens
Towatari, T.; Katunuma, N.
Amino acid sequence of rat liver cathepsin L
FEBS Lett.
236
57-61
1988
Rattus norvegicus
Maciewicz, R.E.; Etherington, D.J.
Enzyme immunoassay for cathepsin B and L in synovial fluids from patients with arthritis
Biochem. Soc. Trans.
16
812-813
1988
Homo sapiens
-
Dufour, E.; Dive, V.; Toma, F.
Delineation of chicken cathepsin L secondary structure; relationship between pH dependence activity and helix content
Biochim. Biophys. Acta
955
58-64
1988
Gallus gallus
Nishimura, Y.; Furuno, K.; Kato, K.
Biosynthesis and processing of lysosomal cathepsin L in primary cultures of rat hepatocytes
Arch. Biochem. Biophys.
263
107-116
1988
Rattus norvegicus
McDonald, J.K.; Kadkhodayan, S.
Cathepsin L: a latent proteinase in guinea pig sperm
Biochem. Biophys. Res. Commun.
151
827-835
1988
Cavia porcellus
Kirschke, H.; Wikstrom, P.; Shaw, E.
Active center differences between cathepsins L and B: the S1 binding region
FEBS Lett.
228
128-130
1988
Rattus norvegicus
Hiwasa, T.; Sakiyama, S.; Yokoyama, S.; Ha, J.M.; Fujita, J.; Noguchi, S.; Bando, Y.; Kominami, E.; Katunuma, N.
Inhibition of cathepsin L-induced degradation of epidermal growth factor receptors by c-Ha-ras gene products
Biochem. Biophys. Res. Commun.
151
78-85
1988
Rattus norvegicus
Ishidoh, K.; Towatari, T.; Imajoh, S.; Kawasaki, H.; Kominami, E.; Katunuma, N.; Suzuki, K.
Molecular cloning and sequencing of cDNA for rat cathepsin L
FEBS Lett.
223
69-73
1987
Rattus norvegicus
Marks, N.; Berg, M.J.
Rat brain cathepsin L: characterization and differentiation from cathepsin B utilizing opioid peptides
Arch. Biochem. Biophys.
259
131-143
1987
Rattus norvegicus
Troen, B.R.; Gal, S.; Gottesman, M.M.
Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin
Biochem. J.
246
731-735
1987
Mus musculus
Dufour, E.; Obled, A.; Valin, C.; Bechet, D.; Ribadeau-Dumas, B.; Huet, J.C.
Purification and amino acid sequence of chicken liver cathepsin L
Biochemistry
26
5689-5695
1987
Gallus gallus
Gal, S.; Gottesman, M.M.
The major excreted protein (MEP) of transformed mouse cells and cathepsin L have similar protease specificity
Biochem. Biophys. Res. Commun.
139
156-162
1986
Mus musculus
Mason, R.W.
Species variants of cathepsin L and their immunological identification
Biochem. J.
240
285-288
1986
Bos taurus, Oryctolagus cuniculus, Ovis aries, Homo sapiens, Rattus norvegicus
Bando, Y.; Kominami, E.; Katunuma, N.
Purification and tissue distribution of rat cathepsin L
J. Biochem.
100
35-42
1986
Rattus norvegicus
Mason, R.W.; Johnson, D.A.; Barrett, A.J.; Chapman, H.A.
Elastinolytic activity of human cathepsin L
Biochem. J.
233
925-927
1986
Homo sapiens
Maciewicz, R.A.; Etherington, D.J.
Separation of cathepsins B, L, N and S from rabbit spleen
Biochem. Soc. Trans.
13
1169-1170
1985
Oryctolagus cuniculus
-
Recklies, A.D.; Mort, J.S.
Rat mammary gland in culture secretes a stable high molecular weight form of cathepsin L
Biochem. Biophys. Res. Commun.
131
402-407
1985
Rattus norvegicus
Mason, R.W.; Green, G.D.J.; Barrett, A.J.
Human liver cathepsin L
Biochem. J.
226
233-241
1985
Homo sapiens
Guncar, G.; Pungercic, G.; Klemencic, I.; Turk, V.; Turk, D.
Crystal structure of HMC class II-associated p41 li fragment bound to cathepsin I reveals the structural basis for differentiation between cathepsin L and S
EMBO J.
18
793-803
1999
Homo sapiens
Pagano, M.; Esnard, F.; Engler, R.; Gauthier, F.
Inhibition of human liver cathepsin L by alpha 2 cysteine-proteinase inhibitor and the low-Mr cysteine proteinase inhibitor from human serum
Biochem. J.
220
147-155
1984
Homo sapiens
Mason, R.W.; Taylor, M.A.J.; Etherington, D.J.
The purification and properties of cathepsin L from rabbit liver
Biochem. J.
217
209-217
1984
Oryctolagus cuniculus
Berri, M.; Rouchon, P.; Zabari, M.; Quali, A.
Purification and characterization of a new potential in vivo inhibitor of cathepsin L from bovine skeletal muscle
Comp. Biochem. Physiol. B
119
283-288
1998
Rattus norvegicus
Kooistra, T.; Millard, P.C.; Lloyd, J.B.
Role of thiols in degradation of proteins by cathepsins
Biochem. J.
204
471-477
1982
Rattus norvegicus
Kirschke, H.; Kembhavi, A.A.; Bohley, P.; Barrett, A.J.
Action of rat liver cathepsin L on collagen and other substrates
Biochem. J.
201
376-372
1982
Rattus norvegicus
-
Gal, S.; Gottesman, M.M.
Isolation and sequence of a cDNA for human pro-(cathepsin L)
Biochem. J.
253
303-306
1988
Homo sapiens
Aranishi, F.; Ogata, H.; Hara, K.; Osatomi, K.; Ishihara, T.M.
Purification and characterization of cathepsin L from hepatopancreas of carp Cyprinus carpio
Comp. Biochem. Physiol. B
118
531-537
1997
Cyprinus carpio, Rattus norvegicus
Hashida, S.; Kominami, E.; Katunuma, N.
Inhibitions of cathepsin B and cathepsin L by E-64 in vivo. II. Incorporation of [3H]E-64 into rat liver lysosomes in vivo
J. Biochem.
91
1373-1380
1982
Rattus norvegicus
Okitani, A.; Matsukura, U.; Kato, H.; Fujimaki, M.
Purification and some properties of a myofibrillar protein-degrading protease, cathepsin L, from rabbit skeletal muscle
J. Biochem.
87
1133-1143
1980
Oryctolagus cuniculus
Kirschke, H.; Langner, J.; Wiederanders, B.; Ansorge, S.; Bohley, P.
Cathepsin L. A new proteinase from rat-liver lysosomes
Eur. J. Biochem.
74
293-301
1977
Rattus norvegicus
Coetzer, T.H.T.; Dennehy, K.M.; Pike, R.N.; Dennison, C.
Baboon (Papio ursinus) cathepsin L: purification, characterization and comparison with human and sheep cathepsin L
Comp. Biochem. Physiol. B
112
429-439
1995
Papio ursinus
Fujishima, A.; Imai, Y.; Nomura, T.; Fujisawa, Y.; Yamamoto, Y.; Sugawara, T.
The crystal structure of human cathepsin L complexed with E-64
FEBS Lett.
407
47-50
1997
Homo sapiens
Ogrinc, T.; Dolenc, I.; Ritonja, A.; Turk, V.
Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidney
FEBS Lett.
336
555-559
1993
Homo sapiens
Katunuma, N.; Kominami, E.
Lysosomal sequestration of cytosolic enzymes and lysosomal thiol cathepsins
Adv. Enzyme Regul.
23
159-168
1985
Rattus norvegicus
Vlkel, H.; Kurz, U.; Linder, J.; Klumpp, S.; Gnau, V.; Jung, G.; Schultz, J.E.
Cathepsin L is an intracellular and extracellular protease in Paramecium tetraurelia. Purification, cloning, sequencing and specific inhibition by its expressed propeptide
Eur. J. Biochem.
238
198-206
1996
Paramecium tetraurelia
Reddy, C.K.; Dhar, S.C.
Purification and characterization of collagenolytic property of renal cathepsin L from arthritic rat
Int. J. Biochem.
24
1465-1473
1992
Rattus norvegicus
Day, S.R.; Dalton, J.P.; Clough, K.A.; Leonardo, L.; Tiu, W.U.; Brindley, P.J.
Characterization and cloning of the cathepsin L proteinase of Schistosoma japonicum
Biochem. Biophys. Res. Commun.
217
1-9
1995
Schistosoma japonicum
Nomura, T.; Fujishima, A.; Fujisawa, Y.
Characterization and crystallization of recombinant human cathepsin L
Biochem. Biophys. Res. Commun.
228
792-796
1996
Homo sapiens
Michel, A.; Ghoneim, H.; Resto, M.; Klinkert, M.Q.; Kunz, W.
Sequence, characterization and localization of a cysteine proteinase cathepsin L in Schistosoma mansoni
Mol. Biochem. Parasitol.
73
7-18
1995
Schistosoma mansoni
Yamashita, M.; Konagaya, S.
Purification and characterization of cathepsin I from the white muscle of chum salmon, Oncorhynchus keta
Comp. Biochem. Physiol. B
96
247-252
1990
Oncorhynchus keta
Estrada, S.; Nycander, M.; Hill, N.J.; Craven, C.J.; Waltho, J.P.; Bjrk, I.
The role of Gly-4 of human cystatin A (stefin A) in the binding of target proteinases. Characterization by kinetic and equilibrium methods of the interactions of cystatin A Gly-4 mutants with papain, cathepsin B, and cathepsin L
Biochemistry
37
7551-7560
1998
Ovis aries
Pike, R.N.; Coetzer, T.H.T.; Dennison, C.
Proteolytic active complexes of cathepsin L and a cysteine proteinase inhibitor. Purification and demonstration of their formation in vitro
Arch. Biochem. Biophys.
294
623-629
1992
Ovis aries
Dennison, C.; Pike, R.; Coetzer, T.; Kirk, K.
Characterization of the activity and stability of single-chain cathepsin L and of proteolytically active cathepsin L/cystatin complexes
Biol. Chem. Hoppe-Seyler
373
419-425
1992
Ovis aries
Raghav, N.; Singh, K.H.
Effect of some steroidal & non-steroidal anti-inflammatory drugs on purified goat brain cathepsin
Indian J. Med. Res.
98
188-192
1993
Capra hircus
Hiwasa, T.; Yokoyama, S.; Ha, J.M.; Noguchi, S.; Sakiyama, S.
c-Ha-ras gene products are potent inhibitors of cathepsin B and L
FEBS Lett.
211
23-26
1987
Rattus norvegicus
Mason, R.W.; Taylor, M.A.J.; Etherington, D.J.
Purification and characterisation of collagenolytic cathepsins from rabbit liver
FEBS Lett.
146
33-36
1982
Oryctolagus cuniculus
Dahl, S.W.; Halkier, T.; Lauritzen, C.; Dolenc, I.; Pedersen, J.; Turk, V.; Turk, B.
Human recombinant Pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing
Biochemistry
40
1671-1678
2001
Homo sapiens
Guay, J.; Falgueyret, J.P.; Ducret, A.; Percival, M.D.; Mancini, J.A.
Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides
Eur. J. Biochem.
267
6311-6318
2000
Homo sapiens
Al-Jassabi, S.
Purification and characterization of cathepsin L from skeletal muscle of the lizard Agama stellio stellio
Biochemistry (Moscow)
65
959-962
2000
Agama stellio stellio
Ohashi, K.; Naruto, M.; Nakaki, T.; Sano, E.
Identification of interleukin-8 converting enzyme as cathepsin L
Biochim. Biophys. Acta
1649
30-39
2003
Homo sapiens
Desmazes, C.; Gauthier, F.; Lalmanach, G.
Cathepsin L, but not cathepsin B, is a potential kininogenase
Biol. Chem.
382
811-815
2001
Homo sapiens
Brinker, A.; Weber, E.; Stoll, D.; Voigt, J.; Muller, A.; Sewald, N.; Jung, G.; Wiesmuller, K.H.; Bohley, P.
Highly potent inhibitors of human cathepsin L identified by screening combinatorial pentapeptide amide collections
Eur. J. Biochem.
267
5085-5092
2000
Homo sapiens
Bocock, J.P.; Edgell, C.J.; Marr, H.S.; Erickson, A.H.
Human proteoglycan testican-1 inhibits the lysosomal cysteine protease cathepsin L
Eur. J. Biochem.
270
4008-4015
2003
Homo sapiens
Fujimoto, K.; Yamamoto, T.; Kitano, T.; Abe, S.
Promotion of cathepsin L activity in newt spermatogonial apoptosis induced by prolactin
FEBS Lett.
521
43-46
2002
Cynops pyrrhogaster
Chiva, C.; Barthe, P.; Codina, A.; Gairi, M.; Molina, F.; Granier, C.; Pugniere, M.; Inui, T.; Nishio, H.; Nishiuchi, Y.; Kimura, T.; Sakakibara, S.; Albericio, F.; Giralt, E.
Synthesis and NMR structure of p41icf, a potent inhibitor of human cathepsin L
J. Am. Chem. Soc.
125
1508-1517
2003
Homo sapiens
Fujii-Taira, I.; Tanaka, Y.; Homma, K.J.; Natori, S.
Hydrolysis and synthesis of substrate proteins for cathepsin L in the brain basement membranes of Sarcophaga during metamorphosis
J. Biochem.
128
539-542
2000
Sarcophaga peregrina
Fiebiger, E.; Maehr, R.; Villadangos, J.; Weber, E.; Erickson, A.; Bikoff, E.; Ploegh, H.L.; Lennon-Dumenil, A.M.
Invariant chain controls the activity of extracellular cathepsin L
J. Exp. Med.
196
1263-1269
2002
Mus musculus
Beers, C.; Honey, K.; Fink, S.; Forbush, K.; Rudensky, A.
Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages
J. Exp. Med.
197
169-179
2003
Mus musculus (P06797)
Falgueyret, J.P.; Oballa, R.M.; Okamoto, O.; Wesolowski, G.; Aubin, Y.; Rydzewski, R.M.; Prasit, P.; Riendeau, D.; Rodan, S.B.; Percival, M.D.
Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L
J. Med. Chem.
44
94-104
2001
Homo sapiens
Chowdhury, S.F.; Sivaraman, J.; Wang, J.; Devanathan, G.; Lachance, P.; Qi, H.; Menard, R.; Lefebvre, J.; Konishi, Y.; Cygler, M.; Sulea, T.; Purisima, E.O.
Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides
J. Med. Chem.
45
5321-5329
2002
Homo sapiens (P07711), Homo sapiens
Klose, A.; Zigrino, P.; Dennhoefer, R.; Mauch, C.; Hunzelmann, N.
Identification and discrimination of extracellularly active cathepsins B and L in high-invasive melanoma cells
Anal. Biochem.
353
57-62
2006
Homo sapiens
Puzer, L.; Cotrin, S.S.; Alves, M.F.; Egborge, T.; Araujo, M.S.; Juliano, M.A.; Juliano, L.; Broemme, D.; Carmona, A.K.
Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L
Arch. Biochem. Biophys.
430
274-283
2004
Homo sapiens
Johnson, G.D.; Jiang, W.
Characterization of cathepsin L secreted by Sf21 insect cells
Arch. Biochem. Biophys.
444
7-14
2005
Spodoptera frugiperda
Hwang, S.R.; Stoka, V.; Turk, V.; Hook, V.
Resistance of cathepsin L compared to elastase to proteolysis when complexed with the serpin endopin 2C, and recovery of cathepsin L activity
Biochem. Biophys. Res. Commun.
340
1238-1243
2006
Homo sapiens
Meh, P.; Pavsic, M.; Turk, V.; Baici, A.; Lenarcic, B.
Dual concentration-dependent activity of thyroglobulin type-1 domain of testican: specific inhibitor and substrate of cathepsin L
Biol. Chem.
386
75-83
2005
Homo sapiens
Mallen-St Clair, J.; Shi, G.P.; Sutherland, R.E.; Chapman, H.A.; Caughey, G.H.; Wolters, P.J.
Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice
Biol. Chem.
387
1143-1146
2006
Mus musculus
Khalikova, T.A.; Zhanaeva, S.Y.; Korolenko, T.A.; Kaledin, V.I.; Kogan, G.
Regulation of activity of cathepsins B, L, and D in murine lymphosarcoma model at a combined treatment with cyclophosphamide and yeast polysaccharide
Cancer Lett.
223
77-83
2005
Mus musculus
Zheng, X.; Chou, P.M.; Mirkin, B.L.; Rebbaa, A.
Senescence-initiated reversal of drug resistance: specific role of cathepsin L
Cancer Res.
64
1773-1780
2004
Homo sapiens
Bylaite, M.; Moussali, H.; Marciukaitiene, I.; Ruzicka, T.; Walz, M.
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases
Exp. Dermatol.
15
110-118
2006
Homo sapiens
Deraison, C.; Darboux, I.; Duportets, L.; Gorojankina, T.; Rahbe, Y.; Jouanin, L.
Cloning and characterization of a gut-specific cathepsin L from the aphid Aphis gossypii
Insect Mol. Biol.
13
165-177
2004
Aphis gossypii
Nepal, R.M.; Mampe, S.; Shaffer, B.; Erickson, A.H.; Bryant, P.
Cathepsin L maturation and activity is impaired in macrophages harboring M. avium and M. tuberculosis
Int. Immunol.
18
931-939
2006
Mus musculus
Laurent-Matha, V.; Derocq, D.; Prebois, C.; Katunuma, N.; Liaudet-Coopman, E.
Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B
J. Biochem.
139
363-371
2006
Homo sapiens
Cheng, T.; Hitomi, K.; van Vlijmen-Willems, I.M.; de Jongh, G.J.; Yamamoto, K.; Nishi, K.; Watts, C.; Reinheckel, T.; Schalkwijk, J.; Zeeuwen, P.L.
Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification
J. Biol. Chem.
281
15893-15899
2006
Homo sapiens
Marquis, R.W.; James, I.; Zeng, J.; Trout, R.E.; Thompson, S.; Rahman, A.; Yamashita, D.S.; Xie, R.; Ru, Y.; Gress, C.J.; Blake, S.; Lark, M.A.; Hwang, S.M.; Tomaszek, T.; Offen, P.; Head, M.S.; Cummings, M.D.; Veber, D.F.
Azepanone-based inhibitors of human cathepsin L
J. Med. Chem.
48
6870-6878
2005
Homo sapiens
Urbich, C.; Heeschen, C.; Aicher, A.; Sasaki, K.; Bruhl, T.; Farhadi, MR.; Vajkoczy, P.; Hofmann, W.K.; Peters, C.; Pennacchio, L.A.; Abolmaali, N.D.; Chavakis, E.; Reinheckel, T.; Zeiher, A.M.; Dimmeler, S.
Cathepsin L is required for endothelial progenitor cell-induced neovascularization
Nat. Med.
11
206-213
2005
Homo sapiens, Mus musculus
Neveu, C.; Abad, P.; Castagnone-Sereno, P.
Molecular cloning and characterization of an intestinal cathepsin L protease from the plant-parasitic nematode Meloidogyne incognita
Physiol. Mol. Plant Pathol.
63
159-165
2004
Meloidogyne incognita
-
Wang, S.Q.; Du, Q.S.; Zhao, K.; Li, A.X.; Wei, D.Q.; Chou, K.C.
Virtual screening for finding natural inhibitor against cathepsin-L for SARS therapy
Amino Acids
33
129-135
2007
Homo sapiens
Anagli, J.; Abounit, K.; Stemmer, P.; Han, Y.; Allred, L.; Weinsheimer, S.; Movsisyan, A.; Seyfried, D.
Effects of cathepsins B and L inhibition on postischemic protein alterations in the brain
Biochem. Biophys. Res. Commun.
366
86-91
2008
Rattus norvegicus (P07154)
Fairhead, M.; Kelly, S.M.; van der Walle, C.F.
A heparin binding motif on the pro-domain of human procathepsin L mediates zymogen destabilization and activation
Biochem. Biophys. Res. Commun.
366
862-867
2008
Homo sapiens (P07711), Homo sapiens
Goulet, B.; Truscott, M.; Nepveu, A.
A novel proteolytically processed CDP/Cux isoform of 90 kDa is generated by cathepsin L
Biol. Chem.
387
1285-1293
2006
Homo sapiens
Caserman, S.; Kenig, S.; Sloane, B.F.; Lah, T.T.
Cathepsin L splice variants in human breast cell lines
Biol. Chem.
387
629-634
2006
Homo sapiens
Sevenich, L.; Pennacchio, L.A.; Peters, C.; Reinheckel, T.
Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice
Biol. Chem.
387
885-891
2006
Homo sapiens
Ohshita, T.; Hiroi, Y.
Cathepsin L plays an important role in the lysosomal degradation of L-lactate dehydrogenase
Biosci. Biotechnol. Biochem.
70
2254-2261
2006
Rattus norvegicus
Vicik, R.; Busemann, M.; Gelhaus, C.; Stiefl, N.; Scheiber, J.; Schmitz, W.; Schulz, F.; Mladenovic, M.; Engels, B.; Leippe, M.; Baumann, K.; Schirmeister, T.
Aziridide-based inhibitors of cathepsin L: synthesis, inhibition activity, and docking studies
ChemMedChem
1
1126-1141
2006
Homo sapiens
Hu, K.J.; Leung, P.C.
Food digestion by cathepsin L and digestion-related rapid cell differentiation in shrimp hepatopancreas
Comp. Biochem. Physiol. B
146
69-80
2007
Metapenaeus ensis (Q7Z0G9), Metapenaeus ensis
Shingles, J.; Lilley, C.J.; Atkinson, H.J.; Urwin, P.E.
Meloidogyne incognita: molecular and biochemical characterisation of a cathepsin L cysteine proteinase and the effect on parasitism following RNAi
Exp. Parasitol.
115
114-120
2007
Meloidogyne incognita, Meloidogyne incognita J2
Hu, Y.; Morioka, K.; Itoh, Y.
Hydrolysis of surimi paste from walleye pollock (Theragra chalcogramma) by cysteine proteinase cathepsin L and effect of the proteinase inhibitor (E-64) on gelation
Food Chem.
104
702-708
2007
Gadus chalcogrammus
Liu, J.; Shi, G.P.; Zhang, W.Q.; Zhang, G.R.; Xu, W.H.
Cathepsin L function in insect moulting: molecular cloning and functional analysis in cotton bollworm, Helicoverpa armigera
Insect Mol. Biol.
15
823-834
2006
Helicoverpa armigera (Q6UB44), Helicoverpa armigera
Liu, H.; Yin, L.; Zhang, N.; Li, S.; Ma, C.
Purification and characterization of cathepsin L from the muscle of silver carp (Hypophthalmichthys molitrix)
J. Agric. Food Chem.
54
9584-9591
2006
Hypophthalmichthys molitrix
Spira, D.; Stypmann, J.; Tobin, D.J.; Petermann, I.; Mayer, C.; Hagemann, S.; Vasiljeva, O.; Guenther, T.; Schuele, R.; Peters, C.; Reinheckel, T.
Cell type-specific functions of the lysosomal protease cathepsin L in the heart
J. Biol. Chem.
282
37045-37052
2007
Homo sapiens, Mus musculus
Novinec, M.; Grass, R.N.; Stark, W.J.; Turk, V.; Baici, A.; Lenarcic, B.
Interaction between human cathepsins K, L, and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors
J. Biol. Chem.
282
7893-7902
2007
Homo sapiens
Sever, S.; Altintas, M.M.; Nankoe, S.R.; Moeller, C.C.; Ko, D.; Wei, C.; Henderson, J.; del Re, E.C.; Hsing, L.; Erickson, A.; Cohen, C.D.; Kretzler, M.; Kerjaschki, D.; Rudensky, A.; Nikolic, B.; Reiser, J.
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease
J. Clin. Invest.
117
2095-2104
2007
Homo sapiens (P07711)
Chowdhury, S.F.; Joseph, L.; Kumar, S.; Tulsidas, S.R.; Bhat, S.; Ziomek, E.; Menard, R.; Sivaraman, J.; Purisima, E.O.
Exploring inhibitor binding at the S subsites of cathepsin L
J. Med. Chem.
51
1361-1368
2008
Homo sapiens
Funkelstein, L.; Toneff, T.; Hwang, S.R.; Reinheckel, T.; Peters, C.; Hook, V.
Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression
J. Neurochem.
106
384-391
2008
Mus musculus, Mus musculus (P06797)
Bulynko, Y.A.; Hsing, L.C.; Mason, R.W.; Tremethick, D.J.; Grigoryev, S.A.
Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin
Mol. Cell. Biol.
26
4172-4184
2006
Mus musculus
Yang, M.; Zhang, Y.; Pan, J.; Sun, J.; Liu, J.; Libby, P.; Sukhova, G.K.; Doria, A.; Katunuma, N.; Peroni, O.D.; Guerre-Millo, M.; Kahn, B.B.; Clement, K.; Shi, G.P.
Cathepsin L activity controls adipogenesis and glucose tolerance
Nat. Cell Biol.
9
970-977
2007
Homo sapiens
Fairhead, M.; van der Walle, C.F.
The heavy-light chain loop of human cathepsin-L modulates its activity and stability
Protein Pept. Lett.
15
47-53
2008
Homo sapiens (P07711), Homo sapiens
Lecaille, F.; Chowdhury, S.; Purisima, E.; Broemme, D.; Lalmanach, G.
The S2 subsites of cathepsins K and L and their contribution to collagen degradation
Protein Sci.
16
662-670
2007
Homo sapiens
Pager, C.T.; Craft, W.W.; Patch, J.; Dutch, R.E.
A mature and fusogenic form of the Nipah virus fusion protein requires proteolytic processing by cathepsin L
Virology
346
251-257
2006
Mus musculus
Liu, Y.; Li, X.; Peng, D.; Tan, Z.; Liu, H.; Qing, Y.; Xue, Y.; Shi, G.P.
Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease
Am. J. Cardiol.
103
476-481
2009
Homo sapiens
Li, W.; Kornmark, L.; Jonasson, L.; Forssell, C.; Yuan, X.M.
Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis
Atherosclerosis
202
92-102
2009
Homo sapiens
Jean, D.; Rousselet, N.; Frade, R.
Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5-untranslated region
Biochem. J.
413
125-134
2008
Homo sapiens
Zheng, X.; Chu, F.; Mirkin, B.L.; Sudha, T.; Mousa, S.A.; Rebbaa, A.
Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy
Biochim. Biophys. Acta
1783
2294-2300
2008
Homo sapiens
Serbielle, C.; Moreau, S.; Veillard, F.; Voldoire, E.; Bezier, A.; Mannucci, M.A.; Volkoff, A.N.; Drezen, J.M.; Lalmanach, G.; Huguet, E.
Identification of parasite-responsive cysteine proteases in Manduca sexta
Biol. Chem.
390
493-502
2009
Manduca sexta
Takahashi, K.; Ueno, T.; Tanida, I.; Minematsu-Ikeguchi, N.; Murata, M.; Kominami, E.
Characterization of CAA0225, a novel inhibitor specific for cathepsin L, as a probe for autophagic proteolysis
Biol. Pharm. Bull.
32
475-479
2009
Homo sapiens, Rattus norvegicus
Myers, M.C.; Shah, P.P.; Beavers, M.P.; Napper, A.D.; Diamond, S.L.; Smith, A.B.; Huryn, D.M.
Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype
Bioorg. Med. Chem. Lett.
18
3646-3651
2008
Homo sapiens
Irie, O.; Ehara, T.; Iwasaki, A.; Yokokawa, F.; Sakaki, J.; Hirao, H.; Kanazawa, T.; Teno, N.; Horiuchi, M.; Umemura, I.; Gunji, H.; Masuya, K.; Hitomi, Y.; Iwasaki, G.; Nonomura, K.; Tanabe, K.; Fukaya, H.; Kosaka, T.; Snell, C.R.; Hallett, A.
Discovery of selective and nonpeptidic cathepsin S inhibitors
Bioorg. Med. Chem. Lett.
18
3959-3962
2008
Homo sapiens
Irie, O.; Yokokawa, F.; Ehara, T.; Iwasaki, A.; Iwaki, Y.; Hitomi, Y.; Konishi, K.; Kishida, M.; Toyao, A.; Masuya, K.; Gunji, H.; Sakaki, J.; Iwasaki, G.; Hirao, H.; Kanazawa, T.; Tanabe, K.; Kosaka, T.; Hart, T.W.; Hallett, A.
4-Amino-2-cyanopyrimidines: novel scaffold for nonpeptidic cathepsin S inhibitors
Bioorg. Med. Chem. Lett.
18
4642-4646
2008
Homo sapiens (P07711)
Irie, O.; Kosaka, T.; Kishida, M.; Sakaki, J.; Masuya, K.; Konishi, K.; Yokokawa, F.; Ehara, T.; Iwasaki, A.; Iwaki, Y.; Hitomi, Y.; Toyao, A.; Gunji, H.; Teno, N.; Iwasaki, G.; Hirao, H.; Kanazawa, T.; Tanabe, K.; Hiestand, P.C.; Malcangio, M.; Fox, A.J.; Bevan, S.J.; Yaqoob, M.; Culshaw, A.J.; Hart, T.W.; Hallet, A.
Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-cyanopyrimidines. Part 2
Bioorg. Med. Chem. Lett.
18
5280-5284
2008
Homo sapiens (P07711)
Ayesa, S.; Lindquist, C.; Agback, T.; Benkestock, K.; Classon, B.; Henderson, I.; Hewitt, E.; Jansson, K.; Kallin, A.; Sheppard, D.; Samuelsson, B.
Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: effect of sulfonamides P3 substituents on potency and selectivity
Bioorg. Med. Chem.
17
1307-1324
2009
Homo sapiens
Zhu, B.W.; Zhao, L.L.; Sun, L.M.; Li, D.M.; Murata, Y.; Yu, L.; Zhang, L.
Purification and characterization of a cathepsin L-like enzyme from the body wall of the sea cucumber Stichopus japonicus
Biosci. Biotechnol. Biochem.
72
1430-1437
2008
Apostichopus japonicus
Herszenyi, L.; Farinati, F.; Cardin, R.; Istvan, G.; Molnar, L.D.; Hritz, I.; De Paoli, M.; Plebani, M.; Tulassay, Z.
Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer
BMC Cancer
8
194
2008
Homo sapiens
Duncan, E.M.; Muratore-Schroeder, T.L.; Cook, R.G.; Garcia, B.A.; Shabanowitz, J.; Hunt, D.F.; Allis, C.D.
Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation
Cell
135
284-294
2008
Mus musculus
Fairhead, M.; Johnson, K.A.; Kowatz, T.; McMahon, S.A.; Carter, L.G.; Oke, M.; Liu, H.; Naismith, J.H.; van der Walle, C.F.
Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras
Chem. Commun. (Camb. )
15
1765-1767
2008
Homo sapiens (P07711)
Lefebvre, C.; Vandenbulcke, F.; Bocquet, B.; Tasiemski, A.; Desmons, A.; Verstraete, M.; Salzet, M.; Cocquerelle, C.
Cathepsin L and cystatin B gene expression discriminates immune coelomic cells in the leech Theromyzon tessulatum
Dev. Comp. Immunol.
32
795-807
2008
Theromyzon tessulatum (Q8IT42), Theromyzon tessulatum
Hook, V.; Funkelstein, L.; Toneff, T.; Mosier, C.; Hwang, S.R.
Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin
Endocrine
35
429-437
2009
Homo sapiens
dos Reis, F.C.; Smith, B.O.; Santos, C.C.; Costa, T.F.; Scharfstein, J.; Coombs, G.H.; Mottram, J.C.; Lima, A.P.
The role of conserved residues of chagasin in the inhibition of cysteine peptidases
FEBS Lett.
582
485-490
2008
Homo sapiens
Yeh, H.Y.; Klesius, P.H.
Channel catfish, Ictalurus punctatus, cysteine proteinases: cloning, characterisation and expression of cathepsin H and L
Fish Shellfish Immunol.
26
332-338
2009
Ictalurus punctatus (B5LVX4), Ictalurus punctatus
Thomas, V.; Samanta, S.; Fikrig, E.
Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function
Infect. Immun.
76
4905-4912
2008
Homo sapiens
Sullivan, S.; Tosetto, M.; Kevans, D.; Coss, A.; Wang, L.; ODonoghue, D.; Hyland, J.; Sheahan, K.; Mulcahy, H.; OSullivan, J.
Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer
Int. J. Cancer
125
54-61
2009
Homo sapiens
Mihelic, M.; Dobersek, A.; Guncar, G.; Turk, D.
Inhibitory fragment from the p41 form of invariant chain can regulate activity of cysteine cathepsins in antigen presentation
J. Biol. Chem.
283
14453-14460
2008
Homo sapiens, Homo sapiens (P07711), Mus musculus, Mus musculus (P06797)
Abboud-Jarrous, G.; Atzmon, R.; Peretz, T.; Palermo, C.; Gadea, B.B.; Joyce, J.A.; Vlodavsky, I.
Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment
J. Biol. Chem.
283
18167-18176
2008
Bos taurus, Homo sapiens
Cailhier, J.F.; Sirois, I.; Laplante, P.; Lepage, S.; Raymond, M.A.; Brassard, N.; Prat, A.; Iozzo, R.V.; Pshezhetsky, A.V.; Hebert, M.J.
Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis
J. Biol. Chem.
283
27220-27229
2008
Homo sapiens
Morin, V.; Sanchez, A.; Quinones, K.; Huidobro, J.G.; Iribarren, C.; Bustos, P.; Puchi, M.; Geneviere, A.M.; Imschenetzky, M.
Cathepsin L inhibitor I blocks mitotic chromosomes decondensation during cleavage cell cycles of sea urchin embryos
J. Cell. Physiol.
216
790-795
2008
Tetrapygus niger
Beavers, M.P.; Myers, M.C.; Shah, P.P.; Purvis, J.E.; Diamond, S.L.; Cooperman, B.S.; Huryn, D.M.; Smith, A.B.
Molecular docking of cathepsin L inhibitors in the binding site of papain
J. Chem. Inf. Model.
48
1464-1472
2008
Homo sapiens (P07711)
Benbrahim-Tallaa, L.; Siddeek, B.; Bozec, A.; Tronchon, V.; Florin, A.; Friry, C.; Tabone, E.; Mauduit, C.; Benahmed, M.
Alterations of Sertoli cell activity in the long-term testicular germ cell death process induced by fetal androgen disruption
J. Endocrinol.
196
21-31
2008
Rattus norvegicus
Yadav, M.R.; Shinde, A.K.; Chouhan, B.S.; Giridhar, R.; Menard, R.
Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors
J. Enzyme Inhib. Med. Chem.
23
190-197
2008
Homo sapiens
Ito, H.; Watanabe, M.; Kim, Y.T.; Takahashi, K.
Inhibition of rat liver cathepsins B and L by the peptide aldehyde benzyloxycarbonyl-leucyl-leucyl-leucinal and its analogues
J. Enzyme Inhib. Med. Chem.
24
279-286
2009
Rattus norvegicus
Nepal, R.M.; Vesosky, B.; Turner, J.; Bryant, P.
DM, but not cathepsin L, is required to control an aerosol infection with Mycobacterium tuberculosis
J. Leukoc. Biol.
84
1011-1018
2008
Mus musculus
Irie, O.; Kosaka, T.; Ehara, T.; Yokokawa, F.; Kanazawa, T.; Hirao, H.; Iwasaki, A.; Sakaki, J.; Teno, N.; Hitomi, Y.; Iwasaki, G.; Fukaya, H.; Nonomura, K.; Tanabe, K.; Koizumi, S.; Uchiyama, N.; Bevan, S.J.; Malcangio, M.; Gentry, C.; Fox, A.J.; Yaqoob, M.; Culshaw, A.J.; Allan Hallett, A.J.
Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain
J. Med. Chem.
51
5502-5505
2008
Homo sapiens, Rattus norvegicus
Urbich, C.; Dernbach, E.; Roessig, L.; Zeiher, A.M.; Dimmeler, S.
High glucose reduces cathepsin L activity and impairs invasion of circulating progenitor cells
J. Mol. Cell. Cardiol.
45
429-436
2008
Homo sapiens
Tang, Q.; Cai, J.; Shen, D.; Bian, Z.; Yan, L.; Wang, Y.X.; Lan, J.; Zhuang, G.Q.; Ma, W.Z.; Wang, W.
Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling
J. Mol. Med.
87
249-260
2009
Homo sapiens
Klein, D.M.; Felsenstein, K.M.; Brenneman, D.E.
Cathepsins B and L differentially regulate amyloid precursor protein processing
J. Pharmacol. Exp. Ther.
328
813-821
2009
Mus musculus
Porotto, M.; Orefice, G.; Yokoyama, C.; Mungall, B.; Realubit, R.; Sganga, M.; Aljofan, M.; Whitt, M.; Glickman, F.; Moscona, A.
Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy
J. Virol.
83
5148-5155
2009
Homo sapiens
Zhang, F.; Zhang, Y.; Li, P.L.
Dependence of cathepsin L-induced coronary endothelial dysfunction upon activation of NAD(P)H oxidase
Microvasc. Res.
78
45-50
2009
Bos taurus
Huang, R.; Que, X.; Hirata, K.; Brinen, L.S.; Lee, J.H.; Hansell, E.; Engel, J.; Sajid, M.; Reed, S.
The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin
Mol. Biochem. Parasitol.
164
86-94
2009
Toxoplasma gondii
Zhu, S.; Wei, L.; Yamasaki, K.; Gallo, R.L.
Activation of cathepsin L by the cathelin-like domain of protegrin-3
Mol. Immunol.
45
2531-2536
2008
Homo sapiens
Shah, P.P.; Myers, M.C.; Beavers, M.P.; Purvis, J.E.; Jing, H.; Grieser, H.J.; Sharlow, E.R.; Napper, A.D.; Huryn, D.M.; Cooperman, B.S.; Smith, A.B.; Diamond, S.L.
Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L
Mol. Pharmacol.
74
34-41
2008
Homo sapiens
Haecker, H.G.; Grundmann, F.; Lohr, F.; Ottersbach, P.A.; Zhou, J.; Schnakenburg, G.; Guetschow, M.
2-Amino- and 2-alkylthio-4H-3,1-benzothiazin-4-ones: synthesis, interconversion and enzyme inhibitory activities
Molecules
14
378-402
2009
Homo sapiens
Hwang, S.R.; Bundey, R.; Toneff, T.; Hook, V.
Endopin serpin protease inhibitors localize with neuropeptides in secretory vesicles and neuroendocrine tissues
Neuroendocrinology
89
210-216
2009
Bos taurus
Navab, R.; Pedraza, C.; Fallavollita, L.; Wang, N.; Chevet, E.; Auguste, P.; Jenna, S.; You, Z.; Bikfalvi, A.; Hu, J.; OConnor, R.; Erickson, A.; Mort, J.S.; Brodt, P.
Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels
Oncogene
27
4973-4985
2008
Mus musculus
Li, Y.; Hu, X.; Liu, X.; Xu, J.; Hu, F.; Ma, C.; Yu, X.
Molecular cloning and analysis of stage and tissue-specific expression of Cathepsin L-like protease from Clonorchis sinensis
Parasitol. Res.
105
447-452
2009
Clonorchis sinensis
Park, Y.; Kong, J.Y.; Cho, H.
A furanquinone from Paulownia tomentosa stem for a new cathepsin K inhibitor
Phytother. Res.
23
1485-1488
2009
Homo sapiens
Biswas, G.; Srinivasan, S.; Anandatheerthavarada, H.K.; Avadhani, N.G.
Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling
Proc. Natl. Acad. Sci. USA
105
186-191
2008
Mus musculus
Hill, J.J.; Moreno, M.J.; Lam, J.C.; Haqqani, A.S.; Kelly, J.F.
Identification of secreted proteins regulated by cAMP in glioblastoma cells using glycopeptide capture and label-free quantification
Proteomics
9
535-549
2009
Homo sapiens
Diederich, S.; Thiel, L.; Maisner, A.
Role of endocytosis and cathepsin-mediated activation in Nipah virus entry
Virology
375
391-400
2008
Chlorocebus aethiops
Sevenich, L.; Hagemann, S.; Stoeckle, C.; Tolosa, E.; Peters, C.; Reinheckel, T.
Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice
Biochimie
92
1674-1680
2010
Homo sapiens
Coppini, L.P.; Barros, N.M.; Oliveira, M.; Hirata, I.Y.; Alves, M.F.; Paschoalin, T.; Assis, D.M.; Juliano, M.A.; Puzer, L.; Broemme, D.; Carmona, A.K.
Plasminogen hydrolysis by cathepsin S and identification of derived peptides as selective substrate for cathepsin V and cathepsin L inhibitor
Biol. Chem.
391
561-570
2010
Homo sapiens
Song, G.; Bailey, D.W.; Dunlap, K.A.; Burghardt, R.C.; Spencer, T.E.; Bazer, F.W.; Johnson, G.A.
Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae
Biol. Reprod.
82
854-864
2010
Sus scrofa
Huryn, D.M.; Smith, A.B.
The identification, characterization and optimization of small molecule probes of cysteine proteases: experiences of the Penn center for molecular discovery with cathepsin B and cathepsin L
Curr. Top. Med. Chem.
9
1206-1216
2009
Homo sapiens
Fontanesi, L.; Speroni, C.; Buttazzoni, L.; Scotti, E.; Costa, L.N.; Davoli, R.; Russo, V.
Association between cathepsin L (CTSL) and cathepsin S (CTSS) polymorphisms and meat production and carcass traits in Italian Large White pigs
Meat Sci.
85
331-338
2010
Sus scrofa (E1UJ48), Sus scrofa
See, V.; Free, P.; Cesbron, Y.; Nativo, P.; Shaheen, U.; Rigden, D.J.; Spiller, D.G.; Fernig, D.G.; White, M.R.; Prior, I.A.; Brust, M.; Lounis, B.; Levy, R.
Cathepsin L digestion of nanobioconjugates upon endocytosis
ACS Nano
3
2461-2468
2009
Homo sapiens
Shimada, N.; Ohno-Matsui, K.; Iseki, S.; Koike, M.; Uchiyama, Y.; Wang, J.; Yoshida, T.; Sato, T.; Peters, C.; Mochizuki, M.; Morita, I.
Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization
Am. J. Pathol.
176
2571-2580
2010
Mus musculus
Zheng, X.; Chu, F.; Chou, P.; Gallati, C.; Dier, U.; Mirkin, B.; Mousa, S.; Rebbaa, A.
Cathepsin L inhibition suppresses drug resistance in vitro and in vivo: A putative mechanism
Am. J. Physiol. Cell Physiol.
296
C65-C74
2009
Homo sapiens
Ahn, S.J.; Sung, J.H.; Kim, N.Y.; Lee, A.R.; Jeon, S.J.; Lee, J.S.; Kim, J.K.; Chung, J.K.; Lee, H.H.
Molecular cloning, expression, and characterization of cathepsin L from mud loach (Misgurnus mizolepis)
Appl. Biochem. Biotechnol.
162
1858-1871
2010
Misgurnus mizolepis (A5HJW4)
Hsu, K.F.; Wu, C.L.; Huang, S.C.; Wu, C.M.; Hsiao, J.R.; Yo, Y.T.; Chen, Y.H.; Shiau, A.L.; Chou, C.Y.
Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells
Autophagy
5
451-460
2009
Homo sapiens
Ueno, T.; Takahashi, K.
A cathepsin L-specific inhibitor preferentially inhibits degradation of autophagosomal LC3 and GABARAP in HeLa and Huh-7 cells
Autophagy
5
878-879
2009
Homo sapiens
Yamazaki, Y.; Kamei, Y.; Sugita, S.; Akaike, F.; Kanai, S.; Miura, S.; Hirata, Y.; Troen, B.R.; Kitamura, T.; Nishino, I.; Suganami, T.; Ezaki, O.; Ogawa, Y.
The cathepsin L gene is a direct target of FOXO1 in skeletal muscle
Biochem. J.
427
171-178
2010
Mus musculus
Fortenberry, Y.M.; Brandal, S.; Bialas, R.C.; Church, F.C.
Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration
Biochim. Biophys. Acta
1800
580-590
2010
Homo sapiens
Schilling, K.; Krner, A.; Sehmisch, S.; Kreusch, A.; Kleint, R.; Benedix, Y.; Schlabrakowski, A.; Wiederanders, B.
Selectivity of propeptide-enzyme interaction in cathepsin L-like cysteine proteases
Biol. Chem.
390
167-174
2009
Homo sapiens
Leto, G.; Sepporta, M.V.; Crescimanno, M.; Flandina, C.; Tumminello, F.M.
Cathepsin L in metastatic bone disease: therapeutic implications
Biol. Chem.
391
655-664
2010
Homo sapiens
Visone, T.; Charron, M.; Wright, W.W.
Activation and repression domains within the promoter of the rat cathepsin L gene orchestrate sertoli cell-specific and stage-specific gene transcription in transgenic mice
Biol. Reprod.
81
571-579
2009
Rattus norvegicus
Asaad, N.; Bethel, P.A.; Coulson, M.D.; Dawson, J.E.; Ford, S.J.; Gerhardt, S.; Grist, M.; Hamlin, G.A.; James, M.J.; Jones, E.V.; Karoutchi, G.I.; Kenny, P.W.; Morley, A.D.; Oldham, K.; Rankine, N.; Ryan, D.; Wells, S.L.; Wood, L.; Augustin, M.; Krapp, S.; Simader, H.; Steinbacher, S.
Dipeptidyl nitrile inhibitors of Cathepsin L
Bioorg. Med. Chem. Lett.
19
4280-4283
2009
Homo sapiens
Kishore Kumar, G.D.; Chavarria, G.E.; Charlton-Sevcik, A.K.; Arispe, W.M.; Macdonough, M.T.; Strecker, T.E.; Chen, S.E.; Siim, B.G.; Chaplin, D.J.; Trawick, M.L.; Pinney, K.G.
Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors
Bioorg. Med. Chem. Lett.
20
1415-1419
2010
Homo sapiens
Fei, X.F.; Qin, Z.H.; Xiang, B.; Li, L.Y.; Han, F.; Fukunaga, K.; Liang, Z.Q.
Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine
Brain Res.
1264
85-97
2009
Rattus norvegicus
Almaguel, F.G.; Liu, J.W.; Pacheco, F.J.; De Leon, D.; Casiano, C.A.; De Leon, M.
Lipotoxicity-mediated cell dysfunction and death involve lysosomal membrane permeabilization and cathepsin L activity
Brain Res.
1318
133-143
2010
Rattus norvegicus
Martinez, O.; Johnson, J.; Manicassamy, B.; Rong, L.; Olinger, G.G.; Hensley, L.E.; Basler, C.F.
Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition
Cell. Microbiol.
12
148-157
2010
Homo sapiens
Biswas, N.; Rodriguez-Flores, J.L.; Courel, M.; Gayen, J.R.; Vaingankar, S.M.; Mahata, M.; Torpey, J.W.; Taupenot, L.; OConnor, D.T.; Mahata, S.K.
Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides
Endocrinology
150
3547-3557
2009
Homo sapiens
Klose, A.; Wilbrand-Hennes, A.; Brinckmann, J.; Hunzelmann, N.
Alternate trafficking of cathepsin L in dermal fibroblasts induced by UVA radiation
Exp. Dermatol.
19
e117-e123
2010
Homo sapiens
Xu, X.; Yuan, G.; Liu, W.; Zhang, Y.; Chen, W.
Expression of cathepsin L in nasopharyngeal carcinoma and its clinical significance
Exp. Oncol.
31
102-105
2009
Homo sapiens
Meemon, K.; Khawsuk, W.; Sriburee, S.; Meepool, A.; Sethadavit, M.; Sansri, V.; Wanichanon, C.; Sobhon, P.
Fasciola gigantica: histology of the digestive tract and the expression of cathepsin L
Exp. Parasitol.
125
371-379
2010
Fasciola gigantica (Q9XYL8), Fasciola gigantica
Zeeuwen, P.L.; van Vlijmen-Willems, I.M.; Cheng, T.; Rodijk-Olthuis, D.; Hitomi, K.; Hara-Nishimura, I.; John, S.; Smyth, N.; Reinheckel, T.; Hendriks, W.J.; Schalkwijk, J.
The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea
FASEB J.
24
3744-3755
2010
Mus musculus
Cardenas-Lopez, J.; Haard, N.
Identification of a cysteine proteinase from Jumbo squid (Dosidicus gigas) hepatopancreas as cathepsin L
Food Chem.
112
442-447
2009
Dosidicus gigas
-
Wartmann, T.; Mayerle, J.; Kaehne, T.; Sahin-Toth, M.; Ruthenbuerger, M.; Matthias, R.; Kruse, A.; Reinheckel, T.; Peters, C.; Weiss, F.U.; Sendler, M.; Lippert, H.; Schulz, H.U.; Aghdassi, A.; Dummer, A.; Teller, S.; Halangk, W.; Lerch, M.M.
Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice
Gastroenterology
138
726-737
2010
Homo sapiens
Konjar, S.; Sutton, V.R.; Hoves, S.; Repnik, U.; Yagita, H.; Reinheckel, T.; Peters, C.; Turk, V.; Turk, B.; Trapani, J.A.; Kopitar-Jerala, N.
Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L
Immunology
131
257-267
2010
Homo sapiens, Mus musculus
Larson, E.T.; Parussini, F.; Huynh, M.H.; Giebel, J.D.; Kelley, A.M.; Zhang, L.; Bogyo, M.; Merritt, E.A.; Carruthers, V.B.
Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl
J. Biol. Chem.
284
26839-26850
2009
Toxoplasma gondii (Q6DMN0), Toxoplasma gondii
Ceru, S.; Konjar, S.; Maher, K.; Repnik, U.; Krizaj, I.; Bencina, M.; Renko, M.; Nepveu, A.; Zerovnik, E.; Turk, B.; Kopitar-Jerala, N.
Stefin B interacts with histones and cathepsin L in the nucleus
J. Biol. Chem.
285
10078-10086
2010
Homo sapiens
Higgins, W.J.; Fox, D.M.; Kowalski, P.S.; Nielsen, J.E.; Worrall, D.M.
Heparin enhances serpin inhibition of the cysteine protease cathepsin L
J. Biol. Chem.
285
3722-3729
2010
Homo sapiens
Puchi, M.; Garcia-Huidobro, J.; Cordova, C.; Aguilar, R.; Dufey, E.; Imschenetzky, M.; Bustos, P.; Morin, V.
A new nuclear protease with cathepsin L properties is present in Hela and Caco-2 cells
J. Cell. Biochem.
111
1099-1106
2010
Homo sapiens
Villa-Mancera, A.; Quiroz-Romero, H.; Correa, D.; Alonso, R.A.
Proteolytic activity in Fasciola hepatica is reduced by the administration of cathepsin L mimotopes
J. Helminthol.
85
51-55
2011
Fasciola hepatica
Shenoy, R.T.; Chowdhury, S.F.; Kumar, S.; Joseph, L.; Purisima, E.O.; Sivaraman, J.
A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors
J. Med. Chem.
52
6335-6346
2009
Homo sapiens (P07711)
Gibbons, A.; McElvaney, N.; Taggart, C.; Cryan, S.
Delivery of rSLPI in a liposomal carrier for inhalation provides protection against cathepsin L degradation
J. Microencapsul.
26
513-522
2009
Homo sapiens
Hu, Y.; Morioka, K.; Itoh, Y.
Participation of cysteine protease cathepsin L in the gel disintegration of red bulleye (Priacanthus macracanthus) surimi gel paste
J. Sci. Food Agric.
90
370-375
2010
Priacanthus macracanthus
Hood, C.L.; Abraham, J.; Boyington, J.C.; Leung, K.; Kwong, P.D.; Nabel, G.J.
Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity
J. Virol.
84
2972-2982
2010
Homo sapiens
Lankelma, J.M.; Voorend, D.M.; Barwari, T.; Koetsveld, J.; Van der Spek, A.H.; De Porto, A.P.; Van Rooijen, G.; Van Noorden, C.J.
Cathepsin L, target in cancer treatment?
Life Sci.
86
225-233
2010
Homo sapiens
Urbanelli, L.; Trivelli, F.; Ercolani, L.; Sementino, E.; Magini, A.; Tancini, B.; Franceschini, R.; Emiliani, C.
Cathepsin L increased level upon Ras mutants expression: the role of p38 and p44/42 MAPK signaling pathways
Mol. Cell. Biochem.
343
49-57
2010
Homo sapiens
Minokadeh, A.; Funkelstein, L.; Toneff, T.; Hwang, S.R.; Beinfeld, M.; Reinheckel, T.; Peters, C.; Zadina, J.; Hook, V.
Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression
Mol. Cell. Neurosci.
43
98-107
2010
Mus musculus
Parussini, F.; Coppens, I.; Shah, P.P.; Diamond, S.L.; Carruthers, V.B.
Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii
Mol. Microbiol.
76
1340-1357
2010
Toxoplasma gondii
Shah, P.P.; Wang, T.; Kaletsky, R.L.; Myers, M.; Puvis, J.E.; Jing, H.; Huryn, D.M.; Greenbaum, D.C.; Smith, A.B.; Bates, P.; Diamond, S.L.
A small molecule oxocarbazate inhibitor of human cathepsin L blocks SARS and Ebola pseudotype virus infection into HEK 293T cells
Mol. Pharmacol.
78
319-324
2010
Homo sapiens
Dennemaerker, J.; Lohmueller, T.; Mayerle, J.; Tacke, M.; Lerch, M.M.; Coussens, L.M.; Peters, C.; Reinheckel, T.
Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis
Oncogene
29
1611-1621
2010
Mus musculus
Rodrigues, A.C.; Garcia, H.A.; Ortiz, P.A.; Cortez, A.P.; Martinkovic, F.; Paiva, F.; Batista, J.S.; Minervino, A.H.; Campaner, M.; Pral, E.M.; Alfieri, S.C.; Teixeira, M.M.
Cysteine proteases of Trypanosoma (Megatrypanum) theileri: Cathepsin L-like gene sequences as targets for phylogenetic analysis, genotyping diagnosis
Parasitol. Int.
59
318-325
2010
Trypanosoma theileri (E5DHH4), Trypanosoma theileri
Beinfeld, M.C.; Funkelstein, L.; Foulon, T.; Cadel, S.; Kitagawa, K.; Toneff, T.; Reinheckel, T.; Peters, C.; Hook, V.
Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies
Peptides
30
1882-1891
2009
Mus musculus
Sansanwal, P.; Shukla, A.A.; Das, T.K.; Chauhan, S.S.
Truncated human cathepsin L, encoded by a novel splice variant, exhibits altered subcellular localization and cytotoxicity
Protein Pept. Lett.
17
238-245
2010
Homo sapiens (Q9HBQ7), Homo sapiens
Yamaguchi, M.; Tahara, Y.; Makino, T.; Shimizu, T.; Date, A.
Comparison of cathepsin L activity in cheek and forearm stratum corneum in young female adults
Skin Res. Technol.
15
370-375
2009
Homo sapiens
Yoshii, H.; Kamiyama, H.; Minematsu, K.; Goto, K.; Mizota, T.; Oishi, K.; Katunuma, N.; Yamamoto, N.; Kubo, Y.
Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells
Virology
394
227-234
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Diederich, S.; Dietzel, E.; Maisner, A.
Nipah virus fusion protein: influence of cleavage site mutations on the cleavability by cathepsin L, trypsin and furin
Virus Res.
145
300-306
2009
Homo sapiens
Savalas, L.R.; Gasnier, B.; Damme, M.; Luebke, T.; Wrocklage, C.; Debacker, C.; Jezegou, A.; Reinheckel, T.; Hasilik, A.; Saftig, P.; Schroeder, B.
Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L
Biochem. J.
439
113-128
2011
Mus musculus
Costa, T.F.; Reis, F.C.; Lima, A.P.
Substrate inhibition and allosteric regulation by heparan sulfate of Trypanosoma brucei cathepsin L
Biochim. Biophys. Acta
1824
493-501
2012
Trypanosoma brucei
Hook, V.; Funkelstein, L.; Wegrzyn, J.; Bark, S.; Kindy, M.; Hook, G.
Cysteine cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimers disease
Biochim. Biophys. Acta
1824
89-104
2012
Mus musculus
Norbury, L.J.; Beckham, S.; Pike, R.N.; Grams, R.; Spithill, T.W.; Fecondo, J.V.; Smooker, P.M.
Adult and juvenile Fasciola cathepsin L proteases: different enzymes for different roles
Biochimie
93
604-611
2011
Fasciola hepatica, Fasciola gigantica
Li, W.W.; Jin, X.K.; He, L.; Jiang, H.; Gong, Y.N.; Xie, Y.N.; Wang, Q.
Molecular cloning, characterization, expression and activity analysis of cathepsin L in Chinese mitten crab, Eriocheir sinensis
Fish Shellfish Immunol.
29
1010-1018
2010
Eriocheir sinensis (E3TGS2), Eriocheir sinensis
Shenoy, R.T.; Sivaraman, J.
Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors
J. Struct. Biol.
173
14-19
2011
Homo sapiens (P07711), Homo sapiens
Adams-Cioaba, M.A.; Krupa, J.C.; Xu, C.; Mort, J.S.; Min, J.
Structural basis for the recognition and cleavage of histone H3 by cathepsin L
Nat. Commun.
2
197
2011
Homo sapiens (P07711), Homo sapiens
Janoir, C.; Pechine, S.; Grosdidier, C.; Collignon, A.
Cwp84, a surface-associated protein of Clostridium difficile, is a cysteine protease with degrading activity on extracellular matrix proteins
J. Bacteriol.
189
7174-7180
2007
Clostridioides difficile (Q83UF3), Clostridioides difficile, Clostridioides difficile 79-685 (Q83UF3)
ChapetonMontes, D.; Candela, T.; Collignon, A.; Janoir, C.
Localization of the Clostridium difficile cysteine protease Cwp84 and insights into its maturation process
J. Bacteriol.
193
5314-5321
2011
Clostridioides difficile (Q83UF3), Clostridioides difficile
Sansri, V.; Changklungmoa, N.; Chaichanasak, P.; Sobhon, P.; Meemon, K.
Molecular cloning, characterization and functional analysis of a novel juvenile-specific cathepsin L of Fasciola gigantica
Acta Trop.
128
76-84
2013
Fasciola gigantica (Q6T857), Fasciola gigantica
Legowska, M.; Wysocka, M.; Burster, T.; Pikula, M.; Rolka, K.; Lesner, A.
Ultrasensitive internally quenched substrates of human cathepsin L
Anal. Biochem.
466
30-37
2014
Homo sapiens
Torkar, A.; Lenarcic, B.; Lah, T.; Dive, V.; Devel, L.
Identification of new peptide amides as selective cathepsin L inhibitors: the first step towards selective irreversible inhibitors?
Bioorg. Med. Chem. Lett.
23
2968-2973
2013
Homo sapiens
Lee, A.R.; Bak, H.J.; Kim, N.Y.; Kim, M.S.; Go, H.J.; Han, J.W.; Ahn, S.J.; Park, N.G.; Chung, J.K.; Lee, H.H.
Cloning, heterologous expression, and enzymatic characterization of cathepsin L from starfish (Asterina pectinifera)
Biosci. Biotechnol. Biochem.
76
2342-2346
2012
Patiria pectinifera (I6QMK7)
Ramalho, S.D.; De Sousa, L.R.; Nebo, L.; Maganhi, S.H.; Caracelli, I.; Zukerman-Schpector, J.; Lima, M.I.; Alves, M.F.; Da Silva, M.F.; Fernandes, J.B.; Vieira, P.C.
Triterpenoids as novel natural inhibitors of human cathepsin L
Chem. Biodivers.
11
1354-1363
2014
Homo sapiens
Pietra, D.; Borghini, A.; Ricci, C.; Bianucci, A.M.
Enzyme kinetics studies on 29-kDa human liver cathepsin L
Chem. Biol. Drug Des.
84
648-658
2014
Homo sapiens (P07711), Homo sapiens
Hu, X.; Hu, X.; Hu, B.; Wen, C.; Xie, Y.; Wu, D.; Tao, Z.; Li, A.; Gao, Q.
Molecular cloning and characterization of cathepsin L from freshwater mussel, Cristaria plicata
Fish Shellfish Immunol.
40
446-454
2014
Cristaria plicata (G1EAS0), Cristaria plicata
Zhong, C.; Cai, Q.; Liu, G.; Sun, L.; Hara, K.; Su, W.; Cao, M.
Purification and characterisation of cathepsin L from the skeletal muscle of blue scad (Decapterus maruadsi) and comparison of its role with myofibril-bound serine proteinase in the degradation of myofibrillar proteins
Food Chem.
133
1560-1568
2012
Decapterus maruadsi
Steverding, D.; Sexton, D.W.; Wang, X.; Gehrke, S.S.; Wagner, G.K.; Caffrey, C.R.
Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target
Int. J. Parasitol.
42
481-488
2012
Trypanosoma brucei
Waniek, P.; Pacheco Costa, J.; Jansen, A.; Costa, J.; Araujo, C.
Cathepsin L of Triatoma brasiliensis (Reduviidae, Triatominae): Sequence characterization, expression pattern and zymography
J. Insect Physiol.
58
178-187
2012
Triatoma brasiliensis (E4W4G9), Triatoma brasiliensis (G9F9V4), Triatoma brasiliensis
Li, Y.; Huang, Y.; Hu, X.; Liu, X.; Ma, C.; Zhao, J.; Wu, Z.; Xu, J.; Yu, X.
41.5-kDa Cathepsin L protease from Clonorchis sinensis: expression, characterization, and serological reactivity of one excretory-secretory antigen
Parasitol. Res.
111
673-680
2012
Clonorchis sinensis (B5G4Y8), Clonorchis sinensis
Wang, Y.R.; Qin, S.; Han, R.; Wu, J.C.; Liang, Z.Q.; Qin, Z.H.; Wang, Y.
Cathepsin L plays a role in quinolinic acid-induced NF-?b activation and excitotoxicity in rat striatal neurons
PLoS ONE
8
e75702
2013
Rattus norvegicus
Sansri, V.; Meemon, K.; Changklungmoa, N.; Kueakhai, P.; Chantree, P.; Chaichanasak, P.; Lorsuwannarat, N.; Itagaki, T.; Sobhon, P.
Protection against Fasciola gigantica infection in mice by vaccination with recombinant juvenile-specific cathepsin L
Vaccine
33
1596-1601
2015
Fasciola gigantica (Q6T857), Fasciola gigantica
Shivanna, V.; Kim, Y.; Chang, K.O.
Endosomal acidification and cathepsin L activity is required for calicivirus replication
Virology
464-465
287-295
2014
feline calicivirus, Murine norovirus 1, Porcine enteric sapovirus
Tamhane, T.; Lllukkumbura, R.; Lu, S.; Maelandsmo, G.M.; Haugen, M.H.; Brix, K.
Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells
Biochimie
122
208-218
2016
Homo sapiens (P07711)
Dana, D.; Garcia, J.; Bhuiyan, A.I.; Rathod, P.; Joo, L.; Novoa, D.A.; Paroly, S.; Fath, K.R.; Chang, E.J.; Pathak, S.K.
Cell penetrable, clickable and tagless activity-based probe of human cathepsin L
Bioorg. Chem.
85
505-514
2019
Homo sapiens (P07711), Homo sapiens
Parker, E.N.; Song, J.; Kishore Kumar, G.D.; Odutola, S.O.; Chavarria, G.E.; Charlton-Sevcik, A.K.; Strecker, T.E.; Barnes, A.L.; Sudhan, D.R.; Wittenborn, T.R.; Siemann, D.W.; Horsman, M.R.; Chaplin, D.J.; Trawick, M.L.; Pinney, K.G.
Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L
Bioorg. Med. Chem.
23
6974-6992
2015
Homo sapiens (P07711), Homo sapiens
Luo, H.; Tie, L.; Cao, M.; Hunter, A.K.; Pabst, T.M.; Du, J.; Field, R.; Li, Y.; Wang, W.K.
Cathepsin L causes proteolytic cleavage of chinese-hamster-ovary cell expressed proteins during processing and storage identification, characterization, and mitigation
Biotechnol. Prog.
35
e2732
2019
Cricetulus griseus (G3INC5), Cricetulus griseus
Jefferson, T.; McShan, D.; Warfield, J.; Ogungbe, I.V.
Screening and identification of inhibitors of Trypanosoma brucei cathepsin L with antitrypanosomal activity
Chem. Biol. Drug Des.
87
154-158
2016
Homo sapiens (P07711), Homo sapiens, Trypanosoma brucei brucei (Q95PM0), Trypanosoma brucei rhodesiense (Q95PM0), Trypanosoma brucei brucei 427 (Q95PM0)
Pranjol, M.Z.I.; Gutowski, N.J.; Hannemann, M.; Whatmore, J.L.
Cathepsin L induces proangiogenic changes in human omental microvascular endothelial cells via activation of the ERK1/2 pathway
Curr. Cancer Drug Targets
19
231-242
2019
Homo sapiens (P07711), Homo sapiens
de Sousa, L.R.; Wu, H.; Nebo, L.; Fernandes, J.B.; da Silva, M.F.; Kiefer, W.; Schirmeister, T.; Vieira, P.C.
Natural products as inhibitors of recombinant cathepsin L of Leishmania mexicana
Exp. Parasitol.
156
42-48
2015
Leishmania mexicana (E9AMH6), Leishmania mexicana
Korenc, M.; Lenarcic, B.; Novinec, M.
Human cathepsin L, a papain-like collagenase without proline specificity
FEBS J.
282
4328-4340
2015
Homo sapiens (P07711), Homo sapiens
Sosnowski, P.; Turk, D.
Caught in the act the crystal structure of cleaved cathepsin L bound to the active site of cathepsin L
FEBS Lett.
590
1253-1261
2016
Homo sapiens (P07711)
Sun, B.G.; Hu, Y.H.
Identification, mRNA expression profiling and activity characterization of cathepsin L from red drum (Sciaenops ocellatus)
Fish Physiol. Biochem.
41
1463-1473
2015
Sciaenops ocellatus (A0A0K0M968), Sciaenops ocellatus
Shen, J.D.; Cai, Q.F.; Yan, L.J.; Du, C.H.; Liu, G.M.; Su, W.J.; Ke, C.; Cao, M.J.
Cathepsin L is an immune-related protein in Pacific abalone (Haliotis discus hannai) - purification and characterization
Fish Shellfish Immunol.
47
986-995
2015
Haliotis discus hannai (K7QTY9), Haliotis discus hannai
Yang, C.; Lin, X.W.; Xu, W.H.
Cathepsin L participates in the remodeling of the midgut through dissociation of midgut cells and activation of apoptosis via caspase-1
Insect Biochem. Mol. Biol.
82
21-30
2017
Helicoverpa armigera (B9UCR2), Helicoverpa armigera
Cao, Y.; Liu, X.; Li, Y.; Lu, Y.; Zhong, H.; Jiang, W.; Chen, A.F.; Billiar, T.R.; Yuan, H.; Cai, J.
Cathepsin L activity correlates with proteinuria in chronic kidney disease in humans
Int. Urol. Nephrol.
49
1409-1417
2017
Homo sapiens (P07711), Homo sapiens
Ma, C.; Liang, K.; Tang, L.; He, S.; Liu, X.; He, M.; Li, Y.
Identification and characteristics of a cathepsin L-like cysteine protease from Clonorchis sinensis
Parasitol. Res.
118
829-835
2019
Clonorchis sinensis (B5G4Y8), Clonorchis sinensis
Ferraro, F.; Merlino, A.; Dell Oca, N.; Gil, J.; Tort, J.F.; Gonzalez, M.; Cerecetto, H.; Cabrera, M.; Corvo, I.
Identification of chalcones as Fasciola hepatica cathepsin L inhibitors using a comprehensive experimental and computational approach
PLoS Negl. Trop. Dis.
10
e0004834
2016
Fasciola hepatica (B3TM67), Fasciola hepatica (Q7JNQ9), Fasciola hepatica
Hernandez Alvarez, L.; Naranjo Feliciano, D.; Hernandez Gonzalez, J.E.; de Oliveira Soares, R.O.; Barreto Gomes, D.E.; Pascutti, P.G.
Insights into the Interactions of Fasciola hepatica cathepsin L3 with a substrate and potential novel inhibitors through in silico approaches
PLoS Negl. Trop. Dis.
9
e0003759
2015
Fasciola hepatica (B3TM67), Fasciola hepatica
Hashimoto, Y.; Kondo, C.; Katunuma, N.
An active 32-kDa cathepsin L is secreted directly from HT 1080 fibrosarcoma cells and not via lysosomal exocytosis
PLoS ONE
10
e0145067
2015
Homo sapiens (P07711), Homo sapiens
Leon-Janampa, N.; Liendo, R.; Gilman, R.H.; Padilla, C.; Garcia, H.H.; Gonzales, A.; Sheen, P.; Pajuelo, M.J.; Zimic, M.; Zimic, M.
Characterization of a novel cathepsin L-like protease from Taenia solium metacestodes for the immunodiagnosis of porcine cysticercosis
Vet. Parasitol.
267
9-16
2019
Taenia solium (A0A1S5WII4), Taenia solium
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