Reference on EC 3.4.21.B7 - mannan-binding lectin-associated serine protease 1
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Takahashi, A.; Takayama, Y.; Hatsuse, H.; Kawakami, M.
Presence of a serine protease in the complement-activating component of the complement-dependent bactericidal factor, RaRF, in mouse serum
Biochem. Biophys. Res. Commun.
190
681-687
1993
Mus musculus
Takada, F.; Takayama, Y.; Hatsuse, H.; Kawakami, M.
A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum
Biochem. Biophys. Res. Commun.
196
1003-1009
1993
Homo sapiens (P48740), Homo sapiens
Matsushita, M.; Ezekowitz, R.A.; Fujita, T.
The Gly-54--Asp allelic form of human mannose-binding protein (MBP) fails to bind MBP-associated serine protease
Biochem. J.
311
1021-1023
1995
Homo sapiens
-
Feinberg, H.; Uitdehaag, J.C.M.; Davies, J.M.; Wallis, R.; Drickamer, K.; Weis, W.I.
Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2
EMBO J.
22
2348-2359
2003
Rattus norvegicus
Matsushita, M.; Endo, Y.; Fujita, T.
MASP1 (MBL-associated serine protease 1)
Immunobiology
199
340-347
1998
Homo sapiens, Mus musculus
Chen, C.B.; Wallis, R.
Stoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activation
J. Biol. Chem.
276
25894-25902
2001
Homo sapiens
Rossi, V.; Cseh, S.; Bally, I.; Thielens, N.M.; Jensenius, J.C.; Arlaud, G.J.
Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2
J. Biol. Chem.
276
40880-40887
2001
Homo sapiens
Takayama, Y.; Takada, F.; Takahashi, A.; Kawakami, M.
A 100-kDa protein in the C4-activating component of Ra-reactive factor is a new serine protease having module organization similar to C1r and C1s
J. Immunol.
152
2308-2316
1994
Mus musculus (P98064), Mus musculus, Mus musculus BALB/c (P98064)
Ogata, R.T.; Low, P.J.; Kawakami, M.
Substrate specificities of the protease of mouse serum Ra-reactive factor
J. Immunol.
154
2351-2357
1995
Mus musculus
Matsushita, M.; Thiel, S.; Jensenius, J.C.; Terai, I.; Fujita, T.
Proteolytic activities of two types of mannose-binding lectin-associated serine protease
J. Immunol.
165
2637-2642
2000
Homo sapiens (P48740), Homo sapiens
Thielens, N.M.; Cseh, S.; Thiel, S.; Vorup-Jensen, T.; Rossi, V.; Jensenius, J.C.; Arlaud, G.J.
Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL
J. Immunol.
166
5068-5077
2001
Homo sapiens
Ambrus, G.; Gal, P.; Kojima, M.; Szilagyi, K.; Balczer, J.; Antal, J.; Graf, L.; Laich, A.; Moffatt, B.E.; Schwaeble, W.; Sim, R.B.; Zavodszky, P.
Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments
J. Immunol.
170
1374-1382
2003
Homo sapiens (P48740)
Chen, C.B.; Wallis, R.
Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases
J. Biol. Chem.
279
26058-26065
2004
Rattus norvegicus
Sorensen, R.; Thiel, S.; Jensenius, J.C.
Mannan-binding-lectin-associated serine proteases, characteristics and disease associations
Semin. Immunopathol.
27
299-319
2005
Homo sapiens
Schwaeble, W.J.; Stover, C.; Reid, K.B.
Mannan-binding lectin-associated serine proteases
Handbook of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
2
1623-1627
2004
Lethenteron camtschaticum, Halocynthia roretzi, Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus laevis, Branchiostoma belcheri
-
Zundel, S.; Cseh, S.; Lacroix, M.; Dahl, M.R.; Matsushita, M.; Andrieu, J.P.; Schwaeble, W.J.; Jensenius, J.C.; Fujita, T.; Arlaud, G.J.; Thielens, N.M.
Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2
J. Immunol.
172
4342-4350
2004
Homo sapiens
Mayilyan, K.R.; Presanis, J.S.; Arnold, J.N.; Hajela, K.; Sim, R.B.
Heterogeneity of MBL-MASP complexes
Mol. Immunol.
43
1286-1292
2006
Homo sapiens
Brown, K.S.; Keogh, M.J.; Tagiuri, N.; Grainge, M.J.; Presanis, J.S.; Ryder, S.D.; Irving, W.L.; Ball, J.K.; Sim, R.B.; Hickling, T.P.
Severe fibrosis in hepatitis C virus-infected patients is associated with increased activity of the mannan-binding lectin (MBL)/MBL-associated serine protease 1 (MASP-1) complex
Clin. Exp. Immunol.
147
90-98
2007
Homo sapiens
Moller-Kristensen, M.; Thiel, S.; Sjoeholm, A.; Matsushita, M.; Jensenius, J.C.
Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway
Int. Immunol.
19
141-149
2007
Homo sapiens
Dobo, J.; Harmat, V.; Sebestyen, E.; Beinrohr, L.; Zavodszky, P.; Gal, P.
Purification, crystallization and preliminary X-ray analysis of human mannose-binding lectin-associated serine protease-1 (MASP-1) catalytic region
Acta Crystallogr. Sect. F
64
781-784
2008
Homo sapiens (P48740), Homo sapiens
Krarup, A.; Gulla, K.C.; Gal, P.; Hajela, K.; Sim, R.B.
The action of MBL-associated serine protease 1 (MASP1) on factor XIII and fibrinogen
Biochim. Biophys. Acta
1784
1294-1300
2008
Homo sapiens (P48740)
Teillet, F.; Gaboriaud, C.; Lacroix, M.; Martin, L.; Arlaud, G.J.; Thielens, N.M.
Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins
J. Biol. Chem.
283
25715-25724
2008
Homo sapiens (P48740), Homo sapiens
Takahashi, M.; Iwaki, D.; Kanno, K.; Ishida, Y.; Xiong, J.; Matsushita, M.; Endo, Y.; Miura, S.; Ishii, N.; Sugamura, K.; Fujita, T.
Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway
J. Immunol.
180
6132-6138
2008
Mus musculus (P98064), Mus musculus
Gal, P.; Dobo, J.; Zavodszky, P.; Sim, R.B.
Early complement proteases: C1r, C1s and MASPs. A structural insight into activation and functions
Mol. Immunol.
46
2745-2752
2009
Homo sapiens (P48740)
Gulla, K.C.; Gupta, K.; Krarup, A.; Gal, P.; Schwaeble, W.J.; Sim, R.B.; OConnor, C.D.; Hajela, K.
Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot
Immunology
129
482-495
2010
Homo sapiens
Kocsis, A.; Kekesi, K.A.; Szasz, R.; Vegh, B.M.; Balczer, J.; Dobo, J.; Zavodszky, P.; Gal, P.; Pal, G.
Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation
J. Immunol.
185
4169-4178
2010
Homo sapiens
Banda, N.K.; Takahashi, M.; Takahashi, K.; Stahl, G.L.; Hyatt, S.; Glogowska, M.; Wiles, T.A.; Endo, Y.; Fujita, T.; Michael Holers, V.; Arend, W.P.
Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement
Mol. Immunol.
49
281-289
2011
Mus musculus
Dobo, J.; Major, B.; Kekesi, K.A.; Szabo, I.; Megyeri, M.; Hajela, K.; Juhasz, G.; Zavodszky, P.; Gal, P.
Cleavage of kininogen and subsequent bradykinin release by the complement component: mannose-binding lectin-associated serine protease (MASP)-1
PLoS ONE
6
e20036
2011
Homo sapiens
Gingras, A.R.; Girija, U.V.; Keeble, A.H.; Panchal, R.; Mitchell, D.A.; Moody, P.C.; Wallis, R.
Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation
Structure
19
1635-1643
2011
Homo sapiens
Sekine, H.; Takahashi, M.; Iwaki, D.; Fujita, T.
The role of MASP-1/3 in complement activation
Adv. Exp. Med. Biol.
735
41-53
2013
Mus musculus (P98064), Mus musculus
Thiel, S.; Jensen, L.; Degn, S.E.; Nielsen, H.J.; Gal, P.; Dobo, J.; Jensenius, J.C.
Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components
Clin. Exp. Immunol.
169
38-48
2012
Homo sapiens (P48740)
Heja, D.; Harmat, V.; Fodor, K.; Wilmanns, M.; Dobo, J.; Kekesi, K.A.; Zavodszky, P.; Gal, P.; Pal, G.
Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 are essential for lectin pathway activation and reveal structural plasticity of MASP-2
J. Biol. Chem.
287
20290-20300
2012
Homo sapiens (P48740)
La Bonte, L.; Pavlov, V.; Tan, Y.; Takahashi, K.; Takahashi, M.; Banda, N.; Zou, C.; Fujita, T.; Stahl, G.
Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis
J. Immunol.
188
885-891
2012
Mus musculus (P98064), Mus musculus
Degn, S.E.; Jensen, L.; Olszowski, T.; Jensenius, J.C.; Thiel, S.
Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44
J. Immunol.
191
1334-1345
2013
Homo sapiens (P48740)
Degn, S.; Jensenius, J.; Thiel, S.
The pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function
J. Immunol.
192
5447-5448
2014
Homo sapiens (P48740), Mus musculus (P48740)
Parej, K.; Hermann, A.; Donath, N.; Zavodszky, P.; Gal, P.; Dobo, J.
Dissociation and re-association studies on the interaction domains of mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, provide evidence for heterodimer formation
Mol. Immunol.
59
1-9
2014
Homo sapiens (P48740), Homo sapiens
Megyeri, M.; Jani, P.K.; Kajdacsi, E.; Dobo, J.; Schwaner, E.; Major, B.; Rigo, J.; Zavodszky, P.; Thiel, S.; Cervenak, L.; Gal, P.
Serum MASP-1 in complex with MBL activates endothelial cells
Mol. Immunol.
59
39-45
2014
Homo sapiens (P48740)
Dobo, J.; Schroeder, V.; Jenny, L.; Cervenak, L.; Zavodszky, P.; Gal, P.
Multiple roles of complement MASP-1 at the interface of innate immune response and coagulation
Mol. Immunol.
61
69-78
2014
Homo sapiens (P48740), Homo sapiens
Jenny, L.; Dobo, J.; Gal, P.; Schroeder, V.
MASP-1 of the complement system promotes clotting via prothrombin activation
Mol. Immunol.
65
398-405
2015
Homo sapiens (P48740)
Hess, K.; Ajjan, R.; Phoenix, F.; Dobo, J.; Gal, P.; Schroeder, V.
Effects of MASP-1 of the complement system on activation of coagulation factors and plasma clot formation
PLoS ONE
7
e35690
2012
Homo sapiens (P48740)
Jani, P.K.; Kajdacsi, E.; Megyeri, M.; Dobo, J.; Doleschall, Z.; Futosi, K.; Timar, C.I.; Mocsai, A.; Mako, V.; Gal, P.; Cervenak, L.
MASP-1 induces a unique cytokine pattern in endothelial cells: a novel link between complement system and neutrophil granulocytes
PLoS ONE
9
e87104
2014
Homo sapiens (P48740), Homo sapiens
Degn, S.E.; Thiel, S.; Jensenius, J.C.
Recombinant expression of the autocatalytic complement protease MASP-1 is crucially dependent on co-expression with its inhibitor, C1 inhibitor
Protein Expr. Purif.
88
173-182
2013
Homo sapiens (P48740), Homo sapiens
Jenny, L.; Ajjan, R.; King, R.; Thiel, S.; Schroeder, V.
Plasma levels of mannan-binding lectin-associated serine proteases MASP-1 and MASP-2 are elevated in type 1 diabetes and correlate with glycaemic control
Clin. Exp. Immunol.
180
227-232
2015
Homo sapiens (P48740), Homo sapiens
Dang, Y.F.; Shen, Y.B.; Xu, X.Y.; Wang, S.T.; Meng, X.Z.; Li, L.S.; Zhang, M.; Hu, M.Y.; Lv, L.Q.; Wang, R.Q.; Li, J.L.
Mannan-binding lectin-associated serine protease-1 (MASP-1) mediates immune responses against Aeromonas hydrophila invitro and invivo in grass carp
Fish Shellfish Immunol.
66
93-102
2017
Ctenopharyngodon idella
Mu, L.; Yin, X.; Wu, H.; Han, K.; Wu, L.; Ding, M.; Bian, X.; Li, B.; Fu, S.; Liang, F.; Guo, Z.; Ye, J.
Expression and functional characterization of a mannose-binding lectin-associated serine protease-1 (MASP-1) from Nile tilapia (Oreochromis niloticus) in host defense against bacterial infection
Fish Shellfish Immunol.
91
68-77
2019
Oreochromis niloticus
Oroszlan, G.; Kortvely, E.; Szakacs, D.; Kocsis, A.; Dammeier, S.; Zeck, A.; Ueffing, M.; Zavodszky, P.; Pal, G.; Gal, P.; Dobo, J.
MASP-1 and MASP-2 do not activate pro-factor D in resting human blood, whereas MASP-3 is a potential activator kinetic analysis involving specific MASP-1 and MASP-2 inhibitors
J. Immunol.
196
857-865
2016
Homo sapiens (P48740), Homo sapiens
Jenny, L.; Dobo, J.; Gal, P.; Schroeder, V.
MASP-1 of the complement system promotes clotting via prothrombin activation
Mol. Immunol.
65
398-405
2015
Homo sapiens (P48740)
Jani, P.K.; Schwaner, E.; Kajdacsi, E.; Debreczeni, M.L.; Ungai-Salanki, R.; Dobo, J.; Doleschall, Z.; Rigo, J.; Geiszt, M.; Szabo, B.; Gal, P.; Cervenak, L.
Complement MASP-1 enhances adhesion between endothelial cells and neutrophils by up-regulating E-selectin expression
Mol. Immunol.
75
38-47
2016
Homo sapiens (P48740), Homo sapiens
Jenny, L.; Dobo, J.; Gal, P.; Schroeder, V.
MASP-1 induced clotting - the first model of prothrombin activation by MASP-1
PLoS ONE
10
e0144633
2015
Homo sapiens (P48740)
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