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Synonyms
egf-bp, epidermal growth factor-binding protein, egf-binding protein, hmw-egf, kallikrein 9, epidermal growth factor urogastrone, high molecular weight epidermal growth factor, human tissue kallikrein 9, s3 kallikrein, kallikrein-related peptidase 9,
more
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2-aminobenzoyl-TSVIRRVQ-ethylenediamine + H2O
?
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-
-
-
?
AAPF-7-amido-4-methylcoumarin + H2O
AAPF + 7-amino-4-methylcoumarin
15% activity compared to LLVY-7-amido-4-methylcoumarin
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-
?
benzyloxycarbonyl-Arg-Val-Arg-Arg-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Arg-Val-Arg-Arg + 7-amino-4-methylcoumarin
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low activity
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-
?
benzyloxycarbonyl-Gln-Arg-Arg-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Gln-Arg-Arg + 7-amino-4-methylcoumarin
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-
-
-
?
benzyloxycarbonyl-Glu-Lys-Lys-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Glu-Lys-Lys + 7-amino-4-methylcoumarin
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low activity
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-
?
benzyloxycarbonyl-Leu-Lys-Arg-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Leu-Lys-Arg + 7-amino-4-methylcoumarin
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-
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-
?
D-Val-Leu-Arg-NHPhNO2
?
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?
gurmarin + H2O
?
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?
L-kininogen + H2O
kinin + ?
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?
LLVY-7-amido-4-methylcoumarin + H2O
LLVY + 7-amino-4-methylcoumarin
preferred substrate
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-
?
Nalpha-benzoyl-L-arginine ethyl ester
?
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?
Nalpha-p-Tosyl-L-arginine methyl ester
?
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?
o-aminobenzoyl-SVIRRVQ-ethylenediamine + H2O
?
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-
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?
o-aminobenzoyl-TSVIRRPQ-ethylenediamine + H2O
?
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-
-
-
?
p-toluenesulfonyl-L-arginine methyl ester + H2O
p-toluenesulfonyl-L-arginine + methyl alcohol
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-
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-
?
polypeptide + H2O
peptides
pre-[epidermal growth factor] + H2O
epidermal growth factor + ?
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-
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-
?
prorenin 2 + H2O
renin 2 + ?
Pyr-Arg-Tyr-Lys-Arg-4-methyl-coumaryl-7-amide + H2O
Pyr-Arg-Tyr-Lys-Arg + 7-amino-4-methylcoumarin
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best substrate
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-
?
tissue kallikrein 10 + H2O
?
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?
additional information
?
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polypeptide + H2O
peptides
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?
polypeptide + H2O
peptides
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?
polypeptide + H2O
peptides
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?
prorenin 2 + H2O
renin 2 + ?
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recombinant substrate, enzymatically inactive proform
product is the enzymatically active enzyme form
?
prorenin 2 + H2O
renin 2 + ?
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specific for mouse prorenin 2 from submandibular gland
product is the enzymatically active enzyme form
?
additional information
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enzyme is regulated by steroid hormones in breast cancer cell line BT-474
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additional information
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the enzyme has strong preference for tyrosine over phenylalanine at the P1 cleavage position
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?
additional information
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the enzyme has strong preference for tyrosine over phenylalanine at the P1 cleavage position
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?
additional information
?
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rK9 is able to accommodate aromatic residues in position P1, and prefer a prolyl and hydrophobic residues in position P2'
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?
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Androgen-Insensitivity Syndrome
Induction of epidermal growth factor by tri-iodo-L-thyronine in the submandibular glands of mice with testicular feminization.
Carcinogenesis
Epidermal Growth Factor (EGF) Autocrine Activation of Human Platelets Promotes EGF Receptor-Dependent Oral Squamous Cell Carcinoma Invasion, Migration, and Epithelial Mesenchymal Transition.
Hypertension
Increased Klk9 Urinary Excretion Is Associated to Hypertension-Induced Cardiovascular Damage and Renal Alterations.
Infections
Epidermal growth factor-binding protein in Mycobacterium avium and Mycobacterium tuberculosis: a possible role in the mechanism of infection.
Neoplasms
Epidermal Growth Factor (EGF) Autocrine Activation of Human Platelets Promotes EGF Receptor-Dependent Oral Squamous Cell Carcinoma Invasion, Migration, and Epithelial Mesenchymal Transition.
Neoplasms
The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-epidermal growth factor (EGF) to active high-molecular-weight EGF.
Ovarian Neoplasms
Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.
Tuberculosis
Epidermal growth factor-binding protein in Mycobacterium avium and Mycobacterium tuberculosis: a possible role in the mechanism of infection.
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Rattus norvegicus (P07647), Mus musculus (P15949), Homo sapiens (Q9UKQ9)
brenda
Yousef, G.M.; Diamandis, E.P.
The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3 (KLK9)
Genomics
65
184-194
2000
Homo sapiens (Q9UKQ9)
brenda
Kikkawa, Y.; Yamanaka, N.; Tada, J.; Kanamori, N.; Tsumura, K.; Hosoi, K.
Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22)
Biochim. Biophys. Acta
1382
55-64
1998
Mus musculus
brenda
El Moujahed, A.; Brillard-Bourdet, M.; Juliano, M.A.; Moreau, T.; Chagas, J.R.; Gutman, N.; Prado, E.S.; Gauthier, F.
Kininogen-derived fluorogenic substrates for investigating the vasoactive properties of rat kallikreins. Identification of a T-kinin-releasing rat kallikrein
Eur. J. Biochem.
247
652-658
1997
Rattus norvegicus
brenda
Tan, O.L.; Whitbread, A.K.; Clements, J.A.; Dong, Y.
Kallikrein-related peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers: do they have a function?
Biol. Chem.
387
697-705
2006
Homo sapiens
brenda
Memari, N.; Grass, L.; Nakamura, T.; Karakucuk, I.; Diamandis, E.P.
Human tissue kallikrein 9: production of recombinant proteins and specific antibodies
Biol. Chem.
387
733-740
2006
Homo sapiens
brenda
Chao, J.
Mouse kallikrein 9, epidermal growth factor-binding protein
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press
2
1602-1603
2004
Mus musculus
-
brenda
Yamada, A.; Nakamura, Y.; Sugita, D.; Shirosaki, S.; Ohkuri, T.; Katsukawa, H.; Nonaka, K.; Imoto, T.; Ninomiya, Y.
Induction of salivary kallikreins by the diet containing a sweet-suppressive peptide, gurmarin, in the rat
Biochem. Biophys. Res. Commun.
346
386-392
2006
Rattus norvegicus
brenda
Angelopoulou, K.; Karagiannis, G.S.
The canine kallikrein-related peptidases 9 and 10: structural characterization and expression in mammary cancer
Mamm. Genome
20
758-767
2010
Canis lupus familiaris (D2IJT6)
brenda
Filippou, P.S.; Farkona, S.; Brinc, D.; Yu, Y.; Prassas, I.; Diamandis, E.P.
Biochemical and functional characterization of the human tissue kallikrein 9
Biochem. J.
474
2417-2433
2017
Homo sapiens (Q9UKQ9), Homo sapiens
brenda
Filippou, P.; Korbakis, D.; Farkona, S.; Soosaipillai, A.; Karakosta, T.; Diamandis, E.P.
A new enzyme-linked immunosorbent assay (ELISA) for human free and bound kallikrein 9
Clin. Proteomics
14
4
2017
Homo sapiens (Q9UKQ9), Homo sapiens
brenda