Reference on EC 3.4.21.B39 - stratum corneum tryptic enzyme
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Mus musculus (P15945), Homo sapiens (Q9Y337)
Yousef, G.M.; Diamandis, E.P.
The new human tissue kallikrein gene family: structure, function, and association to disease
Endocr. Rev.
22
184-204
2001
Homo sapiens (Q9Y337)
Brattsand, M.; Egelrud, T.
Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation
J. Biol. Chem.
274
30033-30040
1999
Homo sapiens (Q9Y337), Homo sapiens
Ekholm, I.E.; Brattsand, M.; Egelrud, T.
Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process?
J. Invest. Dermatol.
114
56-63
2000
Homo sapiens (Q9Y337), Homo sapiens
Yousef, G.M.; Kapadia, C.; Polymeris, M.E.; Borgono, C.; Hutchinson, S.; Wasney, G.A.; Soosaipillai, A.; Diamandis, E.P.
The human kallikrein protein 5 (hK5) is enzymatically active, glycosylated and forms complexes with two protease inhibitors in ovarian cancer fluids
Biochim. Biophys. Acta
1628
88-96
2003
Homo sapiens (Q9Y337), Homo sapiens
Prezas, P.; Arlt, M.J.; Viktorov, P.; Soosaipillai, A.; Holzscheiter, L.; Schmitt, M.; Talieri, M.; Diamandis, E.P.; Krueger, A.; Magdolen, V.
Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells
Biol. Chem.
387
807-811
2006
Homo sapiens
Caubet, C.; Jonca, N.; Brattsand, M.; Guerrin, M.; Bernard, D.; Schmidt, R.; Egelrud, T.; Simon, M.; Serre, G.
Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7
J. Invest. Dermatol.
122
1235-1244
2004
Homo sapiens
Michael, I.P.; Sotiropoulou, G.; Pampalakis, G.; Magklara, A.; Ghosh, M.; Wasney, G.; Diamandis, E.P.
Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression
J. Biol. Chem.
280
14628-14635
2005
Homo sapiens
Michael, I.P.; Pampalakis, G.; Mikolajczyk, S.D.; Malm, J.; Sotiropoulou, G.; Diamandis, E.P.
Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression
J. Biol. Chem.
281
12743-12750
2006
Homo sapiens
Komatsu, N.; Tsai, B.; Sidiropoulos, M.; Saijoh, K.; Levesque, M.A.; Takehara, K.; Diamandis, E.P.
Quantification of eight tissue kallikreins in the Stratum corneum and sweat
J. Invest. Dermatol.
126
925-929
2006
Homo sapiens
Kurlender, L.; Yousef, G.M.; Memari, N.; Robb, J.D.; Michael, I.P.; Borgono, C.; Katsaros, D.; Stephan, C.; Jung, K.; Diamandis, E.P.
Differential expression of a human kallikrein 5 (KLK5) splice variant in ovarian and prostate cancer
Tumour Biol.
25
149-156
2004
Homo sapiens
Yousef, G.M.; White, N.M.; Kurlender, L.; Michael, I.; Memari, N.; Robb, J.D.; Katsaros, D.; Stephan, C.; Jung, K.; Diamandis, E.P.
The kallikrein gene 5 splice variant 2 is a new biomarker for breast and ovarian cancer
Tumour Biol.
25
221-227
2005
Homo sapiens
Petraki, C.D.; Gregorakis, A.K.; Vaslamatzis, M.M.; Papanastasiou, P.A.; Yousef, G.M.; Levesque, M.A.; Diamandis, E.P.
Prognostic Implications of the Immunohistochemical Expression of Human Kallikreins 5, 6, 10 and 11 in Renal Cell Carcinoma
Tumour Biol.
27
1-7
2006
Homo sapiens
Shinoda, Y.; Kozaki, K.; Imoto, I.; Obara, W.; Tsuda, H.; Mizutani, Y.; Shuin, T.; Fujioka, T.; Miki, T.; Inazawa, J.
Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells
Cancer Sci.
98
1078-1086
2007
Homo sapiens
Voegeli, R.; Rawlings, A.V.; Doppler, S.; Heiland, J.; Schreier, T.
Profiling of serine protease activities in human stratum corneum and detection of a stratum corneum tryptase-like enzyme
Int. J. Cosmet. Sci.
29
191-200
2007
Homo sapiens
Debela, M.; Magdolen, V.; Schechter, N.; Valachova, M.; Lottspeich, F.; Craik, C.S.; Choe, Y.; Bode, W.; Goettig, P.
Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences
J. Biol. Chem.
281
25678-25688
2006
Homo sapiens (Q9Y337)
Debela, M.; Goettig, P.; Magdolen, V.; Huber, R.; Schechter, N.M.; Bode, W.
Structural basis of the zinc inhibition of human tissue kallikrein 5
J. Mol. Biol.
373
1017-1031
2007
Homo sapiens (Q9Y337), Homo sapiens
Deraison, C.; Bonnart, C.; Lopez, F.; Besson, C.; Robinson, R.; Jayakumar, A.; Wagberg, F.; Brattsand, M.; Hachem, J.P.; Leonardsson, G.; Hovnanian, A.
LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction
Mol. Biol. Cell
18
3607-3619
2007
Homo sapiens (Q9Y337)
Rajapakse, S.; Ogiwara, K.; Yamano, N.; Kimura, A.; Hirata, K.; Takahashi, S.; Takahashi, T.
Characterization of mouse tissue kallikrein 5
Zool. Sci.
23
963-968
2006
Mus musculus
Shaw, J.L.; Petraki, C.; Watson, C.; Bocking, A.; Diamandis, E.P.
Role of tissue kallikrein-related peptidases in cervical mucus remodeling and host defense
Biol. Chem.
389
1513-1522
2008
Homo sapiens (Q9Y337)
Debela, M.; Beaufort, N.; Magdolen, V.; Schechter, N.M.; Craik, C.S.; Schmitt, M.; Bode, W.; Goettig, P.
Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7
Biol. Chem.
389
623-632
2008
Homo sapiens
Korbakis, D.; Gregorakis, A.K.; Scorilas, A.
Quantitative analysis of human kallikrein 5 (KLK5) expression in prostate needle biopsies: an independent cancer biomarker
Clin. Chem.
55
904-913
2009
Homo sapiens (Q9Y337), Homo sapiens
Pettus, J.R.; Johnson, J.J.; Shi, Z.; Davis, J.W.; Koblinski, J.; Ghosh, S.; Liu, Y.; Ravosa, M.J.; Frazier, S.; Stack, M.S.
Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity
Histol. Histopathol.
24
197-207
2009
Homo sapiens
Brattsand, M.; Stefansson, K.; Hubiche, T.; Nilsson, S.K.; Egelrud, T.
SPINK9: A selective, skin-specific Kazal-type serine protease inhibitor
J. Invest. Dermatol.
129
1656-1665
2009
Homo sapiens
Meyer-Hoffert, U.; Wu, Z.; Schroeder, J.M.
Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor
PLoS ONE
4
e4372
2009
Homo sapiens
Mavridis, K.; Talieri, M.; Scorilas, A.
KLK5 gene expression is severely upregulated in androgen-independent prostate cancer cells after treatment with the chemotherapeutic agents docetaxel and mitoxantrone
Biol. Chem.
391
467-474
2010
Homo sapiens (Q9Y337)
Li, X.; Liu, J.; Wang, Y.; Zhang, L.; Ning, L.; Feng, Y.
Parallel underexpression of kallikrein 5 and kallikrein 7 mRNA in breast malignancies
Cancer Sci.
100
601-607
2009
Homo sapiens
Briot, A.; Deraison, C.; Lacroix, M.; Bonnart, C.; Robin, A.; Besson, C.; Dubus, P.; Hovnanian, A.
Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome
J. Exp. Med.
206
1135-1147
2009
Mus musculus (Q9D140), Mus musculus
Teixeira, T.S.; Freitas, R.F.; Abrahao, O.; Devienne, K.F.; de Souza, L.R.; Blaber, S.I.; Blaber, M.; Kondo, M.Y.; Juliano, M.A.; Juliano, L.; Puzer, L.
Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7
Bioorg. Med. Chem. Lett.
21
6112-6115
2011
Homo sapiens
Britland, S.; Hoyle, M.
Transcriptional gene silencing of kallikrein 5 and kallikrein 7 using siRNA prevents epithelial cell detachment induced by alkaline shock in an in vitro model of eczema
Biotechnol. Prog.
28
485-489
2011
Homo sapiens
Jiang, R.; Shi, Z.; Johnson, J.J.; Liu, Y.; Stack, M.S.
Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma
J. Biol. Chem.
286
9127-9135
2011
Homo sapiens
De Souza, L.; M. Melo, P.; Paschoalin, T.; Carmona, A.; Kondo, M.; Hirata, I.; Blaber, M.; Tersariol, I.; Takatsuka, J.; Juliano, M.; Juliano, L.; Gomes, R.; Puzer, L.
Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
Biochem. Biophys. Res. Commun.
433
333-337
2013
Homo sapiens (Q9Y337)
Sakabe, J.; Yamamoto, M.; Hirakawa, S.; Motoyama, A.; Ohta, I.; Tatsuno, K.; Ito, T.; Kabashima, K.; Hibino, T.; Tokura, Y.
Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes
J. Biol. Chem.
288
17179-17189
2013
Homo sapiens (Q9Y337), Homo sapiens
Santos, J.A.; Kondo, M.Y.; Freitas, R.F.; dos Santos, M.H.; Ramalho, T.C.; Assis, D.M.; Juliano, L.; Juliano, M.A.; Puzer, L.
The natural flavone fukugetin as a mixed-type inhibitor for human tissue kallikreins
Bioorg. Med. Chem. Lett.
26
1485-1489
2016
Homo sapiens
White, G.V.; Edgar, E.V.; Holmes, D.S.; Lewell, X.Q.; Liddle, J.; Polyakova, O.; Smith, K.J.; Thorpe, J.H.; Walker, A.L.; Wang, Y.; Young, R.J.; Hovnanian, A.
Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome
Bioorg. Med. Chem. Lett.
29
821-825
2019
Homo sapiens (Q9Y337)
Hoelz, L.V.B.; Zorzanelli, B.C.; Azevedo, P.H.R.A.; Passos, S.G.; de Souza, L.R.; Zani, M.; Pinheiro, S.; Puzer, L.; Dias, L.R.S.; Muri, E.M.F.
Synthesis, biological evaluation and molecular modeling of pseudo-peptides based statine as inhibitors for human tissue kallikrein 5
Eur. J. Med. Chem.
112
39-47
2016
Homo sapiens (Q9Y337), Homo sapiens
Andoh, T.; Tsujii, K.; Kuraishi, Y.
Increase in pruritogenic kallikrein 5 in the skin of NC mice with chronic dermatitis
Exp. Dermatol.
24
978-980
2015
Mus musculus (P15945)
Yang, F.; Li, J.Y.; Yin, Q.N.; Yang, K.; Dong, S.N.; Bai, L.J.; Liu, P.; Tong, X.W.
Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer tissue expression analysis and relationship with disease course
Genet. Mol. Res.
14
9655-9666
2015
Homo sapiens (Q9Y337), Homo sapiens
Cartner, T.; Brand, N.; Tian, K.; Saud, A.; Carr, T.; Stapleton, P.; Lane, M.E.; Rawlings, A.V.
Effect of different alcohols on stratum corneum kallikrein 5 and phospholipase A2 together with epidermal keratinocytes and skin irritation
Int. J. Cosmet. Sci.
39
188-196
2017
Homo sapiens (Q9Y337)
Jang, H.; Matsuda, A.; Jung, K.; Karasawa, K.; Matsuda, K.; Oida, K.; Ishizaka, S.; Ahn, G.; Amagai, Y.; Moon, C.; Kim, S.H.; Arkwright, P.D.; Takamori, K.; Matsuda, H.; Tanaka, A.
Skin pH is the master switch of kallikrein 5-mediated skin barrier destruction in a murine atopic dermatitis model
J. Invest. Dermatol.
136
127-135
2016
Mus musculus (P15945), Mus musculus
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