Reference on EC 3.4.21.B28 - fibroblast activation protein alpha subunit
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Goldstein, L.A.; Ghersi, G.; Pineiro-Sanchez, M.L.; Salamone, M.; Yeh, Y.; Flessate, D.; Chen, W.T.
Molecular cloning of seprase: a serine integral membrane protease from human melanoma
Biochim. Biophys. Acta
1361
11-19
1997
Homo sapiens (Q12884)
Rettig, W.J.; Garin-Chesa, P.; Healey, J.H.; Su, S.L.; Ozer, H.L.; Schwab, M.; Albino, A.P.; Old, L.J.
Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin
Cancer Res.
53
3327-3335
1993
Homo sapiens
Rettig, W.J.; Su, S.L.; Fortunato, S.R.; Scanlan, M.J.; Raj, B.K.; Garin-Chesa, P.; Healey, J.H.; Old, L.J.
Fibroblast activation protein: purification, epitope mapping and induction by growth factors
Int. J. Cancer
58
385-392
1994
Homo sapiens
Pineiro-Sanchez, M.L.; Goldstein, L.A.; Dodt, J.; Howard, L.; Yeh, Y.; Tran, H.; Argraves, W.S.; Chen, W.T.
Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease
J. Biol. Chem.
272
7595-7601
1997
Homo sapiens (Q12884), Homo sapiens
Park, J.E.; Lenter, M.C.; Zimmermann, R.N.; Garin-Chesa, P.; Old, L.J.; Rettig, W.J.
Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts
J. Biol. Chem.
274
36505-36512
1999
Homo sapiens
Sun, S.; Albright, C.F.; Fish, B.H.; George, H.J.; Selling, B.H.; Hollis, G.F.; Wynn, R.
Expression, purification, and kinetic characterization of full-length human fibroblast activation protein
Protein Expr. Purif.
24
274-281
2002
Homo sapiens (Q12884), Homo sapiens
Iwasa, S.; Okada, K.; Chen, W.T.; Jin, X.; Yamane, T.; Ooi, A.; Mitsumata, M.
Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer
Cancer Lett.
227
229-236
2005
Homo sapiens
Huang, Y.; Wang, S.; Kelly, T.
Seprase promotes rapid tumor growth and increased microvessel density in a mouse model of human breast cancer
Cancer Res.
64
2712-2716
2004
Homo sapiens
Ghersi, G.; Zhao, Q.; Salamone, M.; Yeh, Y.; Zucker, S.; Chen, W.T.
The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices
Cancer Res.
66
4652-4661
2006
Homo sapiens
Acharya, P.S.; Zukas, A.; Chandan, V.; Katzenstein, A.L.; Pure, E.
Fibroblast activation protein: a serine protease expressed at the remodeling interface in idiopathic pulmonary fibrosis
Hum. Pathol.
37
352-360
2006
Homo sapiens
Collins, P.J.; McMahon, G.; OBrien, P.; OConnor, B.
Purification, identification and characterisation of seprase from bovine serum
Int. J. Biochem. Cell Biol.
36
2320-2333
2004
Bos taurus
Aertgeerts, K.; Levin, I.; Shi, L.; Snell, G.P.; Jennings, A.; Prasad, G.S.; Zhang, Y.; Kraus, M.L.; Salakian, S.; Sridhar, V.; Wijnands, R.; Tennant, M.G.
Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha
J. Biol. Chem.
280
19441-19444
2005
Homo sapiens
Ramirez-Montagut, T.; Blachere, N.E.; Sviderskaya, E.V.; Bennett, D.C.; Rettig, W.J.; Garin-Chesa, P.; Houghton, A.N.
FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor
Oncogene
23
5435-5446
2004
Mus musculus, Mus musculus C57BL/6
Mori, Y.; Kono, K.; Matsumoto, Y.; Fujii, H.; Yamane, T.; Mitsumata, M.; Chen, W.T.
The expression of a type II transmembrane serine protease (Seprase) in human gastric carcinoma
Oncology
67
411-419
2004
Homo sapiens
Gilmore, B.F.; Lynas, J.F.; Scott, C.J.; McGoohan, C.; Martin, L.; Walker, B.
Dipeptide proline diphenyl phosphonates are potent, irreversible inhibitors of seprase (FAPalpha)
Biochem. Biophys. Res. Commun.
346
436-446
2006
Homo sapiens
Meadows, S.A.; Edosada, C.Y.; Mayeda, M.; Tran, T.; Quan, C.; Raab, H.; Wiesmann, C.; Wolf, B.B.
Ala657 and conserved active site residues promote fibroblast activation protein endopeptidase activity via distinct mechanisms of transition state stabilization
Biochemistry
46
4598-4605
2007
Homo sapiens (Q12884)
Aggarwal, S.; Brennen, W.N.; Kole, T.P.; Schneider, E.; Topaloglu, O.; Yates, M.; Cotter, R.J.; Denmeade, S.R.
Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites
Biochemistry
47
1076-1086
2008
Homo sapiens
O'Brien, P.; O'Connor, B.F.
Seprase: An overview of an important matrix serine protease
Biochim. Biophys. Acta
1784
1130-1145
2008
Bos taurus, Gallus gallus, Mus musculus (P97321), Homo sapiens (Q12884), Xenopus laevis (Q91651)
Lai, K.S.; Ho, N.; Cheng, J.D.; Tung, C.
Selective fluorescence probes for dipeptidyl peptidase activity-fibroblast activation protein and dipeptidyl peptidase IV
Bioconjug. Chem.
18
1246-1250
2007
Mus musculus
Tran, T.; Quan, C.; Edosada, C.Y.; Mayeda, M.; Wiesmann, C.; Sutherlin, D.; Wolf, B.B.
Synthesis and structure-activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP
Bioorg. Med. Chem. Lett.
17
1438-1442
2007
Homo sapiens (Q12884)
Lee, K.N.; Jackson, K.W.; Christiansen, V.J.; Lee, C.S.; Chun, J.; McKee, P.A.
Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein
Blood
107
1397-1404
2006
Homo sapiens
Christiansen, V.J.; Jackson, K.W.; Lee, K.N.; McKee, P.A.
The effect of a single nucleotide polymorphism on human alpha 2-antiplasmin activity
Blood
109
5286-5292
2007
Homo sapiens
Ge, Y.; Zhan, F.; Barlogie, B.; Epstein, J.; Shaughnessy, J.J.; Yaccoby, S.
Fibroblast activation protein (FAP) is upregulated in myelomatous bone and supports myeloma cell survival
Br. J. Haematol.
133
83-92
2006
Homo sapiens (Q12884), Homo sapiens
Edosada, C.Y.; Quan, C.; Wiesmann, C.; Tran, T.; Sutherlin, D.; Reynolds, M.; Elliott, J.M.; Raab, H.; Fairbrother, W.; Wolf, B.B.
Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity
J. Biol. Chem.
281
7437-7444
2006
Homo sapiens
Lee, K.N.; Jackson, K.W.; Terzyan, S.; Christiansen, V.J.; McKee,P.A.
Using substrate specificity of antiplasmin-cleaving enzyme for fibroblast activation protein inhibitor design
Biochemistry
48
5149-5158
2009
Homo sapiens (Q12884), Homo sapiens
Edosada, C.Y.; Quan, C.; Tran, T.; Pham, V.; Wiesmann, C.; Fairbrother, W.; Wolf, B.B.
Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity
FEBS Lett.
580
1581-1586
2006
Homo sapiens (Q12884)
Kennedy, A.; Dong, H.; Chen, D.; Chen, W.T.
Elevation of seprase expression and promotion of an invasive phenotype by collagenous matrices in ovarian tumor cells
Int. J. Cancer
124
27-35
2009
Homo sapiens (Q12884)
Goscinski, M.A.; Suo, Z.H.; Nesland, J.M.; Chen, W.T.; Zakrzewska, M.; Wang, J.; Zhang, S.; Florenes, V.A.; Giercksky, K.E.
Seprase, dipeptidyl peptidase IV and urokinase-type plasminogen activator expression in dysplasia and invasive squamous cell carcinoma of the esophagus. A study of 229 cases from Anyang Tumor Hospital, Henan Province, China
Oncology
75
49-59
2008
Homo sapiens (Q12884)
Mentlein, R.; Hattermann, K.; Hemion, C.; Jungbluth, A.; Held-Feindt, J.
Expression and role of the cell surface protease seprase/fibroblast activation protein-alpha (FAP-alpha) in astroglial tumors
Biol. Chem.
392
199-207
2011
Homo sapiens
Keane, F.; Nadvi, N.; Yao, T.; Gorrell, M.
Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha
FEBS J.
278
1316-1332
2011
Homo sapiens (Q12884)
Lee, K.; Jackson, K.; Christiansen, V.; Dolence, E.; Mckee, P.
Enhancement of fibrinolysis by inhibiting enzymatic cleavage of precursor alpha2-antiplasmin
J. Thromb. Haemost.
9
987-996
2011
Homo sapiens
Yang, L.; Ma, L.; Lai, D.
Over-expression of fibroblast activation protein alpha increases tumor growth in xenografts of ovarian cancer cells
Acta Biochim. Biophys. Sin. (Shanghai)
45
928-937
2013
Homo sapiens (Q12844)
Jia, J.; Martin, T.A.; Ye, L.; Jiang, W.G.
FAP-alpha (fibroblast activation protein-alpha) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway
BMC Cell Biol.
15
16
2014
Homo sapiens (Q12844)
Yang, W.; Han, W.; Ye, S.; Liu, D.; Wu, J.; Liu, H.; Li, C.; Chen, H.
Fibroblast activation protein-alpha promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanisms
Exp. Mol. Pathol.
95
105-110
2013
Homo sapiens (Q12844)
Jambunathan, K.; Watson, D.S.; Endsley, A.N.; Kodukula, K.; Galande, A.K.
Comparative analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein alpha
FEBS Lett.
586
2507-2512
2012
Homo sapiens (Q12844), Homo sapiens
Keane, F.M.; Yao, T.W.; Seelk, S.; Gall, M.G.; Chowdhury, S.; Poplawski, S.E.; Lai, J.H.; Li, Y.; Wu, W.; Farrell, P.; Vieira de Ribeiro, A.J.; Osborne, B.; Yu, D.M.; Seth, D.; Rahman, K.; Haber, P.; Topaloglu, A.K.; Wang, C.; Thomson, S.; Hennessy, A.; Prins, J.; Twigg, S.M.; McLennan, S.V.; McCaughan, G.W.; Ba, B.a.c.
Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs
FEBS open bio
4
43-54
2013
Papio sp., Mus musculus (P97321), Mus musculus, Homo sapiens (Q12844), Homo sapiens
Jansen, K.; De Winter, H.; Heirbaut, L.; Cheng, J.; Joossens, J.; Lambeir, A.; De Meester, I.; Augustyns, K.; Van Der Veken, P.
Selective inhibitors of fibroblast activation protein (FAP) with a xanthine scaffold
MedChemComm
5
1700-1707
2013
Homo sapiens (Q12844)
-
Knopf, J.D.; Tholen, S.; Koczorowska, M.M.; De Wever, O.; Biniossek, M.L.; Schilling, O.
The stromal cell-surface protease fibroblast activation protein-alpha localizes to lipid rafts and is recruited to invadopodia
Biochim. Biophys. Acta
1853
2515-2525
2015
Homo sapiens
Liu, J.; Huang, C.; Peng, C.; Xu, F.; Li, Y.; Yutaka, Y.; Xiong, B.; Yang, X.
Stromal fibroblast activation protein alpha promotes gastric cancer progression via epithelial-mesenchymal transition through Wnt/ beta-catenin pathway
BMC Cancer
18
1099
2018
Homo sapiens
Lv, B.; Xie, F.; Zhao, P.; Ma, X.; Jiang, W.; Yu, J.; Zhang, X.; Jia, J.
Promotion of cellular growth and motility is independent of enzymatic activity of fibroblast activation protein-alpha
Cancer Genomics Proteomics
13
201-208
2016
Homo sapiens
Bracke, A.; Van Elzen, R.; Van Der Veken, P.; Augustyns, K.; De Meester, I.; Lambeir, A.M.
The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma
Clin. Chim. Acta
495
154-160
2019
Homo sapiens
Busek, P.; Hrabal, P.; Fric, P.; Sedo, A.
Co-expression of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans islets
Histochem. Cell Biol.
143
497-504
2015
Homo sapiens
-
Jia, J.; Martin, T.A.; Ye, L.; Meng, L.; Xia, N.; Jiang, W.G.; Zhang, X.
Fibroblast activation protein-alpha promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways
Int. J. Mol. Med.
41
275-283
2018
Homo sapiens
Zhang, H.E.; Hamson, E.J.; Koczorowska, M.M.; Tholen, S.; Chowdhury, S.; Bailey, C.G.; Lay, A.J.; Twigg, S.M.; Lee, Q.; Roediger, B.; Biniossek, M.L.; ORourke, M.B.; McCaughan, G.W.; Keane, F.M.; Schilling, O.; Gorrell, M.D.
Identification of novel natural substrates of fibroblast activation protein-alpha by differential degradomics and proteomics
Mol. Cell. Proteomics
18
65-85
2019
Mus musculus
Mazur, A.; Holthoff, E.; Vadali, S.; Kelly, T.; Post, S.R.
Cleavage of type I collagen by fibroblast activation protein-alpha enhances class A scavenger receptor mediated macrophage adhesion
PLoS ONE
11
e0150287
2016
Mus musculus
Gunderson, A.; Yamazaki, T.; McCarty, K.; Phillips, M.; Alice, A.; Bambina, S.; Zebertavage, L.; Friedman, D.; Cottam, B.; Newell, P.; Gough, M.; Crittenden, M.; Van der Veken, P.; Young, K.
Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma
PLoS ONE
14
e0211117
2019
Homo sapiens
Busek, P.; Balaziova, E.; Matrasova, I.; Hilser, M.; Tomas, R.; Syrucek, M.; Zemanova, Z.; Krepela, E.; Belacek, J.; Sedo, A.
Fibroblast activation protein alpha is expressed by transformed and stromal cells and is associated with mesenchymal features in glioblastoma
Tumour Biol.
37
13961-13971
2016
Homo sapiens
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