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Reference on EC 3.4.21.B28 - fibroblast activation protein alpha subunit

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Goldstein, L.A.; Ghersi, G.; Pineiro-Sanchez, M.L.; Salamone, M.; Yeh, Y.; Flessate, D.; Chen, W.T.
Molecular cloning of seprase: a serine integral membrane protease from human melanoma
Biochim. Biophys. Acta
1361
11-19
1997
Homo sapiens (Q12884)
Manually annotated by BRENDA team
Rettig, W.J.; Garin-Chesa, P.; Healey, J.H.; Su, S.L.; Ozer, H.L.; Schwab, M.; Albino, A.P.; Old, L.J.
Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin
Cancer Res.
53
3327-3335
1993
Homo sapiens
Manually annotated by BRENDA team
Rettig, W.J.; Su, S.L.; Fortunato, S.R.; Scanlan, M.J.; Raj, B.K.; Garin-Chesa, P.; Healey, J.H.; Old, L.J.
Fibroblast activation protein: purification, epitope mapping and induction by growth factors
Int. J. Cancer
58
385-392
1994
Homo sapiens
Manually annotated by BRENDA team
Pineiro-Sanchez, M.L.; Goldstein, L.A.; Dodt, J.; Howard, L.; Yeh, Y.; Tran, H.; Argraves, W.S.; Chen, W.T.
Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease
J. Biol. Chem.
272
7595-7601
1997
Homo sapiens (Q12884), Homo sapiens
Manually annotated by BRENDA team
Park, J.E.; Lenter, M.C.; Zimmermann, R.N.; Garin-Chesa, P.; Old, L.J.; Rettig, W.J.
Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts
J. Biol. Chem.
274
36505-36512
1999
Homo sapiens
Manually annotated by BRENDA team
Sun, S.; Albright, C.F.; Fish, B.H.; George, H.J.; Selling, B.H.; Hollis, G.F.; Wynn, R.
Expression, purification, and kinetic characterization of full-length human fibroblast activation protein
Protein Expr. Purif.
24
274-281
2002
Homo sapiens (Q12884), Homo sapiens
Manually annotated by BRENDA team
Iwasa, S.; Okada, K.; Chen, W.T.; Jin, X.; Yamane, T.; Ooi, A.; Mitsumata, M.
Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer
Cancer Lett.
227
229-236
2005
Homo sapiens
Manually annotated by BRENDA team
Huang, Y.; Wang, S.; Kelly, T.
Seprase promotes rapid tumor growth and increased microvessel density in a mouse model of human breast cancer
Cancer Res.
64
2712-2716
2004
Homo sapiens
Manually annotated by BRENDA team
Ghersi, G.; Zhao, Q.; Salamone, M.; Yeh, Y.; Zucker, S.; Chen, W.T.
The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices
Cancer Res.
66
4652-4661
2006
Homo sapiens
Manually annotated by BRENDA team
Acharya, P.S.; Zukas, A.; Chandan, V.; Katzenstein, A.L.; Pure, E.
Fibroblast activation protein: a serine protease expressed at the remodeling interface in idiopathic pulmonary fibrosis
Hum. Pathol.
37
352-360
2006
Homo sapiens
Manually annotated by BRENDA team
Collins, P.J.; McMahon, G.; OBrien, P.; OConnor, B.
Purification, identification and characterisation of seprase from bovine serum
Int. J. Biochem. Cell Biol.
36
2320-2333
2004
Bos taurus
Manually annotated by BRENDA team
Aertgeerts, K.; Levin, I.; Shi, L.; Snell, G.P.; Jennings, A.; Prasad, G.S.; Zhang, Y.; Kraus, M.L.; Salakian, S.; Sridhar, V.; Wijnands, R.; Tennant, M.G.
Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha
J. Biol. Chem.
280
19441-19444
2005
Homo sapiens
Manually annotated by BRENDA team
Ramirez-Montagut, T.; Blachere, N.E.; Sviderskaya, E.V.; Bennett, D.C.; Rettig, W.J.; Garin-Chesa, P.; Houghton, A.N.
FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor
Oncogene
23
5435-5446
2004
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Mori, Y.; Kono, K.; Matsumoto, Y.; Fujii, H.; Yamane, T.; Mitsumata, M.; Chen, W.T.
The expression of a type II transmembrane serine protease (Seprase) in human gastric carcinoma
Oncology
67
411-419
2004
Homo sapiens
Manually annotated by BRENDA team
Gilmore, B.F.; Lynas, J.F.; Scott, C.J.; McGoohan, C.; Martin, L.; Walker, B.
Dipeptide proline diphenyl phosphonates are potent, irreversible inhibitors of seprase (FAPalpha)
Biochem. Biophys. Res. Commun.
346
436-446
2006
Homo sapiens
Manually annotated by BRENDA team
Meadows, S.A.; Edosada, C.Y.; Mayeda, M.; Tran, T.; Quan, C.; Raab, H.; Wiesmann, C.; Wolf, B.B.
Ala657 and conserved active site residues promote fibroblast activation protein endopeptidase activity via distinct mechanisms of transition state stabilization
Biochemistry
46
4598-4605
2007
Homo sapiens (Q12884)
Manually annotated by BRENDA team
Aggarwal, S.; Brennen, W.N.; Kole, T.P.; Schneider, E.; Topaloglu, O.; Yates, M.; Cotter, R.J.; Denmeade, S.R.
Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites
Biochemistry
47
1076-1086
2008
Homo sapiens
Manually annotated by BRENDA team
O'Brien, P.; O'Connor, B.F.
Seprase: An overview of an important matrix serine protease
Biochim. Biophys. Acta
1784
1130-1145
2008
Bos taurus, Gallus gallus, Mus musculus (P97321), Homo sapiens (Q12884), Xenopus laevis (Q91651)
Manually annotated by BRENDA team
Lai, K.S.; Ho, N.; Cheng, J.D.; Tung, C.
Selective fluorescence probes for dipeptidyl peptidase activity-fibroblast activation protein and dipeptidyl peptidase IV
Bioconjug. Chem.
18
1246-1250
2007
Mus musculus
Manually annotated by BRENDA team
Tran, T.; Quan, C.; Edosada, C.Y.; Mayeda, M.; Wiesmann, C.; Sutherlin, D.; Wolf, B.B.
Synthesis and structure-activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP
Bioorg. Med. Chem. Lett.
17
1438-1442
2007
Homo sapiens (Q12884)
Manually annotated by BRENDA team
Lee, K.N.; Jackson, K.W.; Christiansen, V.J.; Lee, C.S.; Chun, J.; McKee, P.A.
Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein
Blood
107
1397-1404
2006
Homo sapiens
Manually annotated by BRENDA team
Christiansen, V.J.; Jackson, K.W.; Lee, K.N.; McKee, P.A.
The effect of a single nucleotide polymorphism on human alpha 2-antiplasmin activity
Blood
109
5286-5292
2007
Homo sapiens
Manually annotated by BRENDA team
Ge, Y.; Zhan, F.; Barlogie, B.; Epstein, J.; Shaughnessy, J.J.; Yaccoby, S.
Fibroblast activation protein (FAP) is upregulated in myelomatous bone and supports myeloma cell survival
Br. J. Haematol.
133
83-92
2006
Homo sapiens (Q12884), Homo sapiens
Manually annotated by BRENDA team
Edosada, C.Y.; Quan, C.; Wiesmann, C.; Tran, T.; Sutherlin, D.; Reynolds, M.; Elliott, J.M.; Raab, H.; Fairbrother, W.; Wolf, B.B.
Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity
J. Biol. Chem.
281
7437-7444
2006
Homo sapiens
Manually annotated by BRENDA team
Lee, K.N.; Jackson, K.W.; Terzyan, S.; Christiansen, V.J.; McKee,P.A.
Using substrate specificity of antiplasmin-cleaving enzyme for fibroblast activation protein inhibitor design
Biochemistry
48
5149-5158
2009
Homo sapiens (Q12884), Homo sapiens
Manually annotated by BRENDA team
Edosada, C.Y.; Quan, C.; Tran, T.; Pham, V.; Wiesmann, C.; Fairbrother, W.; Wolf, B.B.
Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity
FEBS Lett.
580
1581-1586
2006
Homo sapiens (Q12884)
Manually annotated by BRENDA team
Kennedy, A.; Dong, H.; Chen, D.; Chen, W.T.
Elevation of seprase expression and promotion of an invasive phenotype by collagenous matrices in ovarian tumor cells
Int. J. Cancer
124
27-35
2009
Homo sapiens (Q12884)
Manually annotated by BRENDA team
Goscinski, M.A.; Suo, Z.H.; Nesland, J.M.; Chen, W.T.; Zakrzewska, M.; Wang, J.; Zhang, S.; Florenes, V.A.; Giercksky, K.E.
Seprase, dipeptidyl peptidase IV and urokinase-type plasminogen activator expression in dysplasia and invasive squamous cell carcinoma of the esophagus. A study of 229 cases from Anyang Tumor Hospital, Henan Province, China
Oncology
75
49-59
2008
Homo sapiens (Q12884)
Manually annotated by BRENDA team
Mentlein, R.; Hattermann, K.; Hemion, C.; Jungbluth, A.; Held-Feindt, J.
Expression and role of the cell surface protease seprase/fibroblast activation protein-alpha (FAP-alpha) in astroglial tumors
Biol. Chem.
392
199-207
2011
Homo sapiens
Manually annotated by BRENDA team
Keane, F.; Nadvi, N.; Yao, T.; Gorrell, M.
Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha
FEBS J.
278
1316-1332
2011
Homo sapiens (Q12884)
Manually annotated by BRENDA team
Lee, K.; Jackson, K.; Christiansen, V.; Dolence, E.; Mckee, P.
Enhancement of fibrinolysis by inhibiting enzymatic cleavage of precursor alpha2-antiplasmin
J. Thromb. Haemost.
9
987-996
2011
Homo sapiens
Manually annotated by BRENDA team
Yang, L.; Ma, L.; Lai, D.
Over-expression of fibroblast activation protein alpha increases tumor growth in xenografts of ovarian cancer cells
Acta Biochim. Biophys. Sin. (Shanghai)
45
928-937
2013
Homo sapiens (Q12844)
Manually annotated by BRENDA team
Jia, J.; Martin, T.A.; Ye, L.; Jiang, W.G.
FAP-alpha (fibroblast activation protein-alpha) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway
BMC Cell Biol.
15
16
2014
Homo sapiens (Q12844)
Manually annotated by BRENDA team
Yang, W.; Han, W.; Ye, S.; Liu, D.; Wu, J.; Liu, H.; Li, C.; Chen, H.
Fibroblast activation protein-alpha promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanisms
Exp. Mol. Pathol.
95
105-110
2013
Homo sapiens (Q12844)
Manually annotated by BRENDA team
Jambunathan, K.; Watson, D.S.; Endsley, A.N.; Kodukula, K.; Galande, A.K.
Comparative analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein alpha
FEBS Lett.
586
2507-2512
2012
Homo sapiens (Q12844), Homo sapiens
Manually annotated by BRENDA team
Keane, F.M.; Yao, T.W.; Seelk, S.; Gall, M.G.; Chowdhury, S.; Poplawski, S.E.; Lai, J.H.; Li, Y.; Wu, W.; Farrell, P.; Vieira de Ribeiro, A.J.; Osborne, B.; Yu, D.M.; Seth, D.; Rahman, K.; Haber, P.; Topaloglu, A.K.; Wang, C.; Thomson, S.; Hennessy, A.; Prins, J.; Twigg, S.M.; McLennan, S.V.; McCaughan, G.W.; Ba, B.a.c.
Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs
FEBS open bio
4
43-54
2013
Papio sp., Mus musculus (P97321), Mus musculus, Homo sapiens (Q12844), Homo sapiens
Manually annotated by BRENDA team
Jansen, K.; De Winter, H.; Heirbaut, L.; Cheng, J.; Joossens, J.; Lambeir, A.; De Meester, I.; Augustyns, K.; Van Der Veken, P.
Selective inhibitors of fibroblast activation protein (FAP) with a xanthine scaffold
MedChemComm
5
1700-1707
2013
Homo sapiens (Q12844)
-
Manually annotated by BRENDA team
Knopf, J.D.; Tholen, S.; Koczorowska, M.M.; De Wever, O.; Biniossek, M.L.; Schilling, O.
The stromal cell-surface protease fibroblast activation protein-alpha localizes to lipid rafts and is recruited to invadopodia
Biochim. Biophys. Acta
1853
2515-2525
2015
Homo sapiens
Manually annotated by BRENDA team
Liu, J.; Huang, C.; Peng, C.; Xu, F.; Li, Y.; Yutaka, Y.; Xiong, B.; Yang, X.
Stromal fibroblast activation protein alpha promotes gastric cancer progression via epithelial-mesenchymal transition through Wnt/ beta-catenin pathway
BMC Cancer
18
1099
2018
Homo sapiens
Manually annotated by BRENDA team
Lv, B.; Xie, F.; Zhao, P.; Ma, X.; Jiang, W.; Yu, J.; Zhang, X.; Jia, J.
Promotion of cellular growth and motility is independent of enzymatic activity of fibroblast activation protein-alpha
Cancer Genomics Proteomics
13
201-208
2016
Homo sapiens
Manually annotated by BRENDA team
Bracke, A.; Van Elzen, R.; Van Der Veken, P.; Augustyns, K.; De Meester, I.; Lambeir, A.M.
The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma
Clin. Chim. Acta
495
154-160
2019
Homo sapiens
Manually annotated by BRENDA team
Busek, P.; Hrabal, P.; Fric, P.; Sedo, A.
Co-expression of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans islets
Histochem. Cell Biol.
143
497-504
2015
Homo sapiens
-
Manually annotated by BRENDA team
Jia, J.; Martin, T.A.; Ye, L.; Meng, L.; Xia, N.; Jiang, W.G.; Zhang, X.
Fibroblast activation protein-alpha promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways
Int. J. Mol. Med.
41
275-283
2018
Homo sapiens
Manually annotated by BRENDA team
Zhang, H.E.; Hamson, E.J.; Koczorowska, M.M.; Tholen, S.; Chowdhury, S.; Bailey, C.G.; Lay, A.J.; Twigg, S.M.; Lee, Q.; Roediger, B.; Biniossek, M.L.; ORourke, M.B.; McCaughan, G.W.; Keane, F.M.; Schilling, O.; Gorrell, M.D.
Identification of novel natural substrates of fibroblast activation protein-alpha by differential degradomics and proteomics
Mol. Cell. Proteomics
18
65-85
2019
Mus musculus
Manually annotated by BRENDA team
Mazur, A.; Holthoff, E.; Vadali, S.; Kelly, T.; Post, S.R.
Cleavage of type I collagen by fibroblast activation protein-alpha enhances class A scavenger receptor mediated macrophage adhesion
PLoS ONE
11
e0150287
2016
Mus musculus
Manually annotated by BRENDA team
Gunderson, A.; Yamazaki, T.; McCarty, K.; Phillips, M.; Alice, A.; Bambina, S.; Zebertavage, L.; Friedman, D.; Cottam, B.; Newell, P.; Gough, M.; Crittenden, M.; Van der Veken, P.; Young, K.
Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma
PLoS ONE
14
e0211117
2019
Homo sapiens
Manually annotated by BRENDA team
Busek, P.; Balaziova, E.; Matrasova, I.; Hilser, M.; Tomas, R.; Syrucek, M.; Zemanova, Z.; Krepela, E.; Belacek, J.; Sedo, A.
Fibroblast activation protein alpha is expressed by transformed and stromal cells and is associated with mesenchymal features in glioblastoma
Tumour Biol.
37
13961-13971
2016
Homo sapiens
Manually annotated by BRENDA team