Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
endothelial lipase + H2O
?
-
-
-
?
human immunodeficiency virus type 1 Vpr + H2O
?
undergoes proteolytic processing at a very well conserved proprotein convertase cleavage site, R85QRR88-/-, proprotein convertases PC5 and PACE4 can efficiently process extracellular Vpr
-
-
?
Lefty protein + H2O
?
-
-
-
?
PCSK9 + H2O
truncated PCSK9-DELTAN218 + ?
-
-
-
?
preprohepcidin + H2O
?
key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin
-
-
?
pro-cocaine- and amphetamine-regulated transcript precursor + H2O
bioactive pro-cocaine- and amphetamine-regulated transcript I + bioactive pro-cocaine- and amphetamine-regulated transcript II + ?
PC5/6A preferentially cleaves the pairs of basic sites, KR/KK, of the CART precursor isoforms
-
-
?
pyroglutamic acid-RTKR-7-amido-4-methylcoumarin + H2O
pyroglutamic acid-RTKR + 7-amino-4-methylcoumarin
-
-
-
?
2-aminobenzoic acid-SKKRKRRFLG-(3-nitro)-Tyr-A + H2O
2-aminobenzoic acid-SKKRKRR + FLG-(3-nitro)-Tyr-A
-
fluorogenic substrate encompassing the processing site of envelope glycoproteins of respiratory syncytial virus
-
?
2-aminobenzoyl-GGRRTRREAI-(3-nitro)-Tyr-A + H2O
2-aminobenzoyl-GGRRTRR + EAI-(3-nitro)-Tyr-A
-
fluorogenic substrate encompassing the processing site of envelope glycoproteins of ebola virus
-
?
2-aminobenzoyl-RNTPRERKKRGL-(3-nitro)-Tyr-A + H2O
2-aminobenzoyl-RNTPRERKKR + GL-(3-nitro)-Tyr-A
-
-
-
?
2-aminobenzoyl-RNTPRERRRKKRGL-(3-nitro)-Tyr-A + H2O
2-aminobenzoyl-RNTPRERRRKKR + GL-(3-nitro)-Tyr-A
-
fluorogenic substrate encompassing the processing site of envelope glycoproteins of Hong Kong virus
-
?
2-aminobenzoyl-RNTPRKKRGL-(3-nitro)-Tyr-A + H2O
2-aminobenzoyl-RNTPRKKR + GL-(3-nitro)-Tyr-A
-
-
-
?
2-aminobenzoyl-RNTPRRRKKRGL-(3-nitro)-Tyr-A + H2O
2-aminobenzoyl-RNTPRRRKKR + GL-(3-nitro)-Tyr-A
-
-
-
?
2-aminobenzoyl-SKKRKRRFLG-(3-nitro)-Tyr-A + H2O
2-aminobenzoyl-SKKRKRR + FLG-(3-nitro)-Tyr-A
-
-
-
-
?
pro-von Willebrand factor + H2O
von Willebrand factor + ?
-
-
-
?
additional information
?
-
osteopontin + H2O
?
Pcsk5/PCSK5 is temporally and spatially expressed with Opn/OPN (Spp1/SPP1) in osteoblasts and osteocytes, indicating that osteopontin could be a physiologically relevant substrate for PC5/6 or PC5/6-activated proteases in bone. Cleavage of osteopontin may modify the function of osteopontin in bone and/or modulate other enzymatic cleavages of osteopontin, leading to alterations in the bone phenotype
-
-
?
osteopontin + H2O
?
the enzyme (PC5/6A) efficiently and completely cleaves human osteopontin into three distinct fragments migrating at about 50 kDa, about 18 kDa, and 16 kDa, with evidence for the predicted cleavage sites being at 168RSKSKKFR175-/- and 241KQSR244-/-. PC5/6 also partially cleaves mouse osteopontin to release fragments of about 30 kDa and 29 kDa
-
-
?
additional information
?
-
death at birth of the PC5/6-deficient embryos
-
-
?
additional information
?
-
-
no substrate: amyloid-beta precursor protein
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Basak, A.; Zhong, M.; Munzer, J.S.; Chretien, M.; Seidah, N.G.
Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides
Biochem. J.
353
537-545
2001
Mus musculus
brenda
De Strooper, B.; Creemers, J.W.; Moechars, D.; Huylebroeck, D.; Van De Ven, W.J.; Van Leuven, F.; Van den Berghe, H.
Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes
Biochim. Biophys. Acta
1246
185-188
1995
Mus musculus
brenda
De Bie, I.; Marcinkiewicz, M.; Malide, D.; Lazure, C.; Nakayama, K.; Bendayan, M.; Seidah, N.G.
The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments
J. Cell. Biol.
135
1261-1275
1996
Mus musculus
brenda
Tang, M.; Mikhailik, A.; Pauli, I.; Giudice, L.C.; Fazelabas, A.T.; Tulac, S.; Carson, D.D.; Kaufman, D.G.; Barbier, C.; Creemers, J.W.; Tabibzadeh, S.
Decidual differentiation of stromal cells promotes proprotein convertase 5/6 expression and lefty processing
Endocrinology
146
5313-5320
2005
Mus musculus (Q04592), Mus musculus
brenda
Seidah, N.G.; Chretien, M.
Proprotein convertase 5
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press
2
1874-1877
2004
Homo sapiens, Mus musculus, Rattus norvegicus
-
brenda
Essalmani, R.; Hamelin, J.; Marcinkiewicz, J.; Chamberland, A.; Mbikay, M.; Chretien, M.; Seidah, N.G.; Prat, A.
Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse
Mol. Cell. Biol.
26
354-361
2006
Homo sapiens (Q92824), Mus musculus
brenda
Stein, J.; Shah, R.; Steiner, D.F.; Dey, A.
RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor
Biochem. J.
400
209-215
2006
Mus musculus (Q04592)
brenda
Dikeakos, J.D.; Mercure, C.; Lacombe, M.; Seidah, N.G.; Reudelhuber, T.L.
PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism
FEBS J.
274
4094-4102
2007
Mus musculus
brenda
Seidah, N.G.; Mayer, G.; Zaid, A.; Rousselet, E.; Nassoury, N.; Poirier, S.; Essalmani, R.; Prat, A.
The activation and physiological functions of the proprotein convertases
Int. J. Biochem. Cell Biol.
40
1111-1125
2008
Mus musculus (Q04592)
brenda
Mayer, G.; Hamelin, J.; Asselin, M.; Pasquato, A.; Marcinkiewicz, E.; Tang, M.; Tabibzadeh, S.; Seidah, N.G.
The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates
J. Biol. Chem.
283
2373-2384
2008
Mus musculus (Q04592)
brenda
Reynolds Nicole , R.N.; Blum Aliss, B.A.; Kitagawa Kouk, K.K.; Beinfeld, M.C.
Inhibition of PC5 expression decreases CCK secretion and increases PC2 expression
Peptides
27
901-904
2006
Mus musculus (Q04592), Mus musculus
brenda
Padua, M.B.; Hansen, P.J.
Regulation of DNA synthesis and the cell cycle in human prostate cancer cells and lymphocytes by ovine uterine serpin
BMC Cell Biol.
9
5
2008
Mus musculus (Q04592)
brenda
Essalmani, R.; Zaid, A.; Marcinkiewicz, J.; Chamberland, A.; Pasquato, A.; Seidah, N.G.; Prat, A.
In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate
Proc. Natl. Acad. Sci. USA
105
5750-5755
2008
Mus musculus (Q04592), Mus musculus
brenda
Xiao, Y.; Chen, G.; Richard, J.; Rougeau, N.; Li, H.; Seidah, N.G.; Cohen, E.A.
Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases
Virology
372
384-397
2008
Mus musculus (Q04592)
brenda
Sun, X.; Essalmani, R.; Seidah, N.G.; Prat, A.
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model
Mol. Cancer
8
73
2009
Mus musculus
brenda
Fritzsche, J.; Stawowy, P.
Time for endothelial cell proprotein convertase PC5/6 in cardiovascular medicine?
J. Mol. Med.
89
1061-1063
2011
Mus musculus
brenda
Hoac, B.; Susan-Resiga, D.; Essalmani, R.; Marcinkiweicz, E.; Seidah, N.G.; McKee, M.D.
Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone
Bone
107
45-55
2018
Mus musculus (Q04592)
brenda