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Information on EC 3.4.21.B26 - proprotein convertase 5 and Organism(s) Rattus norvegicus and UniProt Accession P41413

for references in articles please use BRENDA:EC3.4.21.B26
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B26 proprotein convertase 5
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Rattus norvegicus
UNIPROT: P41413
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
cleavage at the RX(K/R)R consensus motif. Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-/-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.
Synonyms
pc5/6, pcsk5, pc5/6a, pc5-a, proprotein convertase 5/6, prohormone convertase 5, proprotein convertase subtilisin/kexin type 5, pc5-b, pc5/6b, proprotein convertase 5, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CAS REGISTRY NUMBER
COMMENTARY hide
99676-46-7
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
0.05 mM inhibits PC activity and consequently av cleavage
PC5-specific antisense oligonucleotide-1
inhibits PC activity and consequently av cleavage
PC5-specific antisense oligonucleotide-2
inhibits PC activity and consequently av cleavage, most potent inhibitor
Rapamycin
strongly inhibits
additional information
av cleavage not inhibited by the MMP-inhibitor GM6001 and PC5-specific antisense oligonucleotide-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
trans-Golgi network
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PCSK5_RAT
1809
0
201308
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
117000
-
SDS-PAGE, soluble PC5 isolated from the medium of GH4-C1 cells infected with the vaccinia virus recombinant
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partially purified, DEAE column
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
medicine
-
crucial role in heart development and in endothelial cells, involved in embryonic bone morphogenesis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stawowy, P.; Kallisch, H.; Veinot, J.P.; Kilimnik, A.; Prichett, W.; Goetze, S.; Seidah, N.G.; Chretien, M.; Fleck, E.; Graf, K.
Endoproteolytic activation of av integrin by proprotein convertase PC5 is required for Vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling
Circulation
109
770-776
2004
Homo sapiens (Q92824), Rattus norvegicus (P41413)
Manually annotated by BRENDA team
Seidah, N.G.; Chretien, M.
Proprotein convertase 5
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press
2
1874-1877
2004
Homo sapiens, Mus musculus, Rattus norvegicus
-
Manually annotated by BRENDA team
Stawowy Philip, S.P.; Fleck Eckar, F.E.
Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels
J. Mol. Med.
83
865-875
2005
Homo sapiens (Q92824), Rattus norvegicus (P41413)
Manually annotated by BRENDA team