Reference on EC 3.4.21.B2 - granzyme M
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Smyth, M.J.; O'Connor, M.D.; Kelly, J.M.; Ganesvaran, P.; Thia, K.Y.; Trapani, J.A.
Expression of recombinant human Met-ase-1: a NK cell-specific granzyme
Biochem. Biophys. Res. Commun.
217
675-683
1995
Homo sapiens
Sattar, R.; Ali, S.A.; Abbasi, A.
Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling
Biochem. Biophys. Res. Commun.
308
726-735
2003
Homo sapiens
Smyth, M.J.; O'Connor, M.D.; Trapani, J.A.; Kershaw, M.H.; Brinkworth, R.I.
A novel substrate-binding pocket interaction restricts the specificity of the human NK cell-specific serine protease, Met-ase-1
J. Immunol.
156
4174-4181
1996
Homo sapiens
Bade, B.; Boettcher, H.E.; Lohrmann, J.; Hink-Schauer, C.; Bratke, K.; Jenne, D.E.; Virchow, J.C., Jr.; Luttmann, W.
Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes
Int. Immunol.
17
1419-1428
2005
Homo sapiens (P51124)
Pao L.I.; Sumaria N.; Kelly J.M.; van Dommelen S.; Cretney E.; Wallace M.E.; Anthony D.A.; Uldrich A.P.; Godfrey D.I.; Papadimitriou J.M.; Mullbacher A.; Degli-Esposti M.A.; Smyth M.J.
Functional analysis of granzyme M and its role in immunity to infection
J. Immunol.
175
3235-3243
2005
Mus musculus
Rukamp, B.J.; Kam, C.M.; Natarajan, S.; Bolton, B.W.; Smyth, M.J.; Kelly, J.M.; Powers, J.C.
Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates
Arch. Biochem. Biophys.
422
9-22
2004
Homo sapiens (P51124), Homo sapiens, Rattus norvegicus (Q03238)
Kelly, J.M.; Waterhouse, N.J.; Cretney, E.; Browne, K.A.; Ellis, S.; Trapani, J.A.; Smyth, M.J.
Granzyme M mediates a novel form of perforin-dependent cell death
J. Biol. Chem.
279
22236-22242
2004
Homo sapiens
Mahrus, S.; Kisiel, W.; Craik, C.S.
Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B
J. Biol. Chem.
279
54275-54282
2004
Homo sapiens
Lu, H.; Hou, Q.; Zhao, T.; Zhang, H.; Zhang, Q.; Wu, L.; Fan, Z.
Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation
J. Immunol.
177
1171-1178
2006
Homo sapiens
Morice, W.G.; Jevremovic, D.; Hanson, C.A.
The expression of the novel cytotoxic protein granzyme M by large granular lymphocytic leukaemias of both T-cell and NK-cell lineage: an unexpected finding with implications regarding the pathobiology of these disorders
Br. J. Haematol.
137
237-239
2007
Homo sapiens
Hua, G.; Zhang, Q.; Fan, Z.
Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme M-mediated apoptosis
J. Biol. Chem.
282
20553-20560
2007
Homo sapiens (P51124)
Cullen, S.P.; Afonina, I.S.; Donadini, R.; Luethi, A.U.; Medema, J.P.; Bird, P.I.; Martin, S.J.
Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing
J. Biol. Chem.
284
5137-5147
2009
Homo sapiens (P51124), Homo sapiens
Bovenschen, N.; de Koning, P.J.; Quadir, R.; Broekhuizen, R.; Damen, J.M.; Froelich, C.J.; Slijper, M.; Kummer, J.A.
NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network
J. Immunol.
180
8184-8191
2008
Homo sapiens (P51124), Homo sapiens
Wu, L.; Wang, L.; Hua, G.; Liu, K.; Yang, X.; Zhai, Y.; Bartlam, M.; Sun, F.; Fan, Z.
Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M
J. Immunol.
183
421-429
2009
Homo sapiens (P51124), Homo sapiens
Froelich, C.J.; Pardo, J.; Simon, M.M.
Granule-associated serine proteases: granzymes might not just be killer proteases
Trends Immunol.
30
117-123
2009
Mus musculus (O08643), Homo sapiens (P51124), Rattus norvegicus (Q03238)
Hu, D.; Liu, S.; Shi, L.; Li, C.; Wu, L.; Fan, Z.
Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells
J. Biol. Chem.
285
18326-18335
2010
Homo sapiens (P51124)
Anthony, D.A.; Andrews, D.M.; Chow, M.; Watt, S.V.; House, C.; Akira, S.; Bird, P.I.; Trapani, J.A.; Smyth, M.J.
A role for granzyme M in TLR4-driven inflammation and endotoxicosis
J. Immunol.
185
1794-1803
2010
Mus musculus
Khurshid, R.; Saleem, M.; Akhtar, M.S.; Salim, A.
Granzyme M: Characterization with sites of post-translational modification and specific sites of interaction with substrates and inhibitors
Mol. Biol. Rep.
392
199-207
2010
Homo sapiens (P51124), Homo sapiens
de Koning, P.J.; Tesselaar, K.; Bovenschen, N.; Colak, S.; Quadir, R.; Volman, T.J.; Kummer, J.A.
The cytotoxic protease granzyme M is expressed by lymphocytes of both the innate and adaptive immune system
Mol. Immunol.
47
903-911
2010
Homo sapiens (P51124), Homo sapiens
De Poot, S.; Lai, K.; Hovingh, E.; Bovenschen, N.
Granzyme M cannot induce cell death via cleavage of mouse FADD
Apoptosis
18
533-534
2013
Mus musculus (O08643), Mus musculus, Homo sapiens (P51124)
Schiffer, S.; Letzian, S.; Jost, E.; Mladenov, R.; Hristodorov, D.; Huhn, M.; Fischer, R.; Barth, S.; Thepen, T.
Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells
Cancer Lett.
341
178-185
2013
Homo sapiens (P51124), Homo sapiens
van Domselaar, R.; de Poot, S.A.; Remmerswaal, E.B.; Lai, K.W.; ten Berge, I.J.; Bovenschen, N.
Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication
Cell Death Differ.
20
419-429
2013
Homo sapiens (P51124), Homo sapiens
de Poot, S.A.; Lai, K.W.; van der Wal, L.; Plasman, K.; Van Damme, P.; Porter, A.C.; Gevaert, K.; Bovenschen, N.
Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis
Cell Death Differ.
21
416-426
2014
Homo sapiens (P51124), Homo sapiens
Souza-Fonseca-Guimaraes, F.; Krasnova, Y.; Putoczki, T.; Miles, K.; MacDonald, K.P.; Town, L.; Shi, W.; Gobe, G.C.; McDade, L.; Mielke, L.A.; Tye, H.; Masters, S.L.; Belz, G.T.; Huntington, N.D.; Radford-Smith, G.; Smyth, M.J.
Granzyme M has a critical role in providing innate immune protection in ulcerative colitis
Cell Death Dis.
7
e2302
2016
Homo sapiens (P51124), Homo sapiens
Wensink, A.C.; Wiewel, M.A.; Jongeneel, L.H.; Boes, M.; van der Poll, T.; Hack, C.E.; Bovenschen, N.
Granzyme M and K release in human experimental endotoxemia
Immunobiology
221
773-777
2016
Homo sapiens (P51124), Homo sapiens
Wang, H.; Sun, Q.; Wu, Y.; Wang, L.; Zhou, C.; Ma, W.; Zhang, Y.; Wang, S.; Zhang, S.
Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation
Oncotarget
6
5818-5831
2015
Mus musculus (O08643), Mus musculus, Homo sapiens (P51124), Homo sapiens
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