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Information on EC 3.4.21.B2 - granzyme M and Organism(s) Rattus norvegicus and UniProt Accession Q03238

for references in articles please use BRENDA:EC3.4.21.B2
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B2 granzyme M
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This record set is specific for:
Rattus norvegicus
UNIPROT: Q03238
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
endopeptidase activity. Cleaves substrates containing a methionine side chain at P1
Synonyms
granzyme m, met-ase-1, gzm m, hgzmm, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CAS REGISTRY NUMBER
COMMENTARY hide
159745-66-1
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
a series of peptide phosphonates and chloromethyl ketones tested, neither inhibitor type proved to be especially potent toward the enzyme, including the general serine protease inhibitor, 3,4-dichloroisocoumarin
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GRAM_RAT
258
0
28339
Swiss-Prot
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, Hepes buffer, pH 7.5, several months
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rukamp, B.J.; Kam, C.M.; Natarajan, S.; Bolton, B.W.; Smyth, M.J.; Kelly, J.M.; Powers, J.C.
Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates
Arch. Biochem. Biophys.
422
9-22
2004
Homo sapiens (P51124), Homo sapiens, Rattus norvegicus (Q03238)
Manually annotated by BRENDA team
Froelich, C.J.; Pardo, J.; Simon, M.M.
Granule-associated serine proteases: granzymes might not just be killer proteases
Trends Immunol.
30
117-123
2009
Mus musculus (O08643), Homo sapiens (P51124), Rattus norvegicus (Q03238)
Manually annotated by BRENDA team