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ezrin + H2O
?
granzyme M directly and efficiently cleaves the actin-plasma membrane linker ezrin
-
-
?
heterogeneous nuclear ribonucleoprotein K + H2O
?
-
granzyme M most efficiently cleaves heterogeneous nuclear ribonucleoprotein K in the presence of RNA at multiple sites, thereby likely destroying heterogeneous nuclear ribonucleoprotein K function
-
?
human Fas-associated protein with Death Domain + H2O
?
-
cleavage at residue Met196
-
?
mouse Fas-associated protein with Death Domain mutant V193M/L194S + H2O
?
no substrate: wild-type mouse Fas-associated protein with Death Domain lacking a residue corresponding to Met196 of the human substrate
cleavage at residue M193
-
?
N-benzyloxycarbonyl-alanyl-alanyl-methionine-thiobenzylester + H2O
N-benzyloxycarbonyl-alanyl-alanyl-methionine + phenylmethanethiol
-
-
-
?
N-benzyloxycarbonyl-alanyl-alanyl-prolyl-methionine-thiobenzylester + H2O
N-benzyloxycarbonyl-alanyl-alanyl-prolyl-methionine + phenylmethanethiol
-
-
-
?
N-benzyloxycarbonyl-alanyl-aspartyl-methionine-thiobenzylester + H2O
-benzyloxycarbonyl-alanyl-aspartyl-methionine + phenylmethanethiol
-
-
-
?
N-benzyloxycarbonyl-alanyl-lysyl-methionine-thiobenzylester + H2O
N-benzyloxycarbonyl-alanyl-lysyl-methionine + phenylmethanethiol
-
-
-
?
N-benzyloxycarbonyl-alanyl-prolyl-methionine-thiobenzylester + H2O
N-benzyloxycarbonyl-alanyl-prolyl-methionine + phenylmethanethiol
-
-
-
?
N-benzyloxycarbonyl-alanyl-seryl-methionine-thiobenzylester + H2O
N-benzyloxycarbonyl-alanyl-seryl-methionine + phenylmethanethiol
-
-
-
?
N-benzyloxycarbonyl-aspartyl-prolyl-methionine-thiobenzylester + H2O
N-benzyloxycarbonyl-aspartyl-prolyl-methionine + phenylmethanethiol
-
-
-
?
N-benzyloxycarbonyl-L-Phe-L-Pro-L-Met-thiobenzyl ester + H2O
?
-
-
-
?
N-benzyloxycarbonyl-lysyl-prolyl-methionine-thiobenzylester + H2O
N-benzyloxycarbonyl-lysyl-prolyl-methionine + phenylmethanethiol
-
-
-
?
N-benzyloxycarbonyl-prolyl-prolyl-methionine-thiobenzylester + H2O
N-benzyloxycarbonyl-prolyl-prolyl-methionine + phenylmethanethiol
-
-
-
?
N-benzyloxycarbonyl-seryl-prolyl-methionine-thiobenzylester + H2O
N-benzyloxycarbonyl-seryl-prolyl-methionine + phenylmethanethiol
-
-
-
?
N2-Cbz-L-Asp(O-tBut)-L-Pro-L-Met thiobenzyl ester + H2O
N2-Cbz-L-Asp(O-tBut)-L-Pro-L-Met + phenylmethanethiol
-
-
-
?
N2-CBZ-O3-tBut-L-Ser-L-Pro-L-Met-SBzl + H2O
N2-CBZ-O3-tBut-L-Ser-L-Pro-L-Met + phenylmethanethiol
-
-
-
?
N2-[(benzyloxy)carbonyl]-N6-(tert-butoxycarbonyl)-L-lysyl-L-prolyl-L-methionyl thiobenzyl ester + H2O
N2-[(benzyloxy)carbonyl]-N6-(tert-butoxycarbonyl)-L-lysyl-L-prolyl-L-methionine + phenylmethanethiol
-
-
-
?
survivin + H2O
?
the inhibitor of the apoptosis gene family member survivin is a physiological substrate for GzmM. GzmM hydrolyzes survivin at Leu-138 to remove the last four C-terminal residues. The truncated form is more rapidly hydrolyzed through proteasome-mediated degradation
-
-
?
topoisomerase II alpha + H2O
?
-
cleavage of topoisomerase II alpha by granzyme M at Leu1280 separates topoisomerase II alpha functional domains from the nuclear localization signals and leads to nuclear exit of topoisomerase II alpha catalytic activity
-
?
tumor necrosis factor receptor-associated protein 1 + H2O
?
-
-
-
?
acetyl-GRLL-7-amido-4-methylcoumarin + H2O
acetyl-GRLL + 7-amino-4-methylcoumarin
-
-
-
-
?
acetyl-KEPL-7-amido-4-methylcoumarin + H2O
acetyl-KEPL + 7-amino-4-methylcoumarin
-
-
-
-
?
acetyl-KEPM-7-amido-4-methylcoumarin + H2O
acetyl-KEPM + 7-amino-4-methylcoumarin
-
-
-
-
?
acetyl-KVAM-7-amido-4-methylcoumarin + H2O
acetyl-KVAM + 7-amino-4-methylcoumarin
-
-
-
-
?
acetyl-KVPL-7-amido-4-methylcoumarin + H2O
acetyl-KVPL + 7-amino-4-methylcoumarin
-
-
-
-
?
acetyl-KVPM-7-amido-4-methylcoumarin + H2O
acetyl-KVPM + 7-amino-4-methylcoumarin
-
-
-
-
?
acetyl-KYAL-7-amido-4-methylcoumarin + H2O
acetyl-KYAL + 7-amino-4-methylcoumarin
-
-
-
-
?
acetyl-KYPL-7-amido-4-methylcoumarin + H2O
acetyl-KYPL + 7-amino-4-methylcoumarin
-
-
-
-
?
acetyl-KYPM-7-amido-4-methylcoumarin + H2O
acetyl-KYPM + 7-amino-4-methylcoumarin
-
-
-
-
?
acetyl-MEPL-7-amido-4-methylcoumarin + H2O
acetyl-MEPL + 7-amino-4-methylcoumarin
-
-
-
-
?
acetyl-RYPL-7-amido-4-methylcoumarin + H2O
acetyl-RYPL + 7-amino-4-methylcoumarin
-
-
-
-
?
acetyl-VPL-7-amido-4-methylcoumarin + H2O
acetyl-VPL + 7-amino-4-methylcoumarin
-
-
-
-
?
inhibitor of caspase-activated DNase + H2O
?
N-tert-butoxycarbonyl-Ala-Ala-Met thiobenzyl ester + H2O
N-tert-butoxycarbonyl-Ala-Ala-Met + phenylmethanethiol
-
activity only occurs with deletion mutants, but not with wild-type enzyme
-
?
N-tert-butoxycarbonyl-Ala-Ala-Met-thiobenzyl ester + H2O
N-tert-butoxycarbonyl-Ala-Ala-Met + phenylmethanethiol
-
cleaves thiobenzylester substrates specifically after methionine, norleucine or leucine residues in the primary substrate site P1
-
?
poly(ADP-ribose) polymerase + H2O
?
proteinase inhibitor 9 + H2O
?
-
effective hydrolysis and inactivation, bypassing proteinase inhibitor 9 inhibition of granzyme B
-
-
?
succinyl-Ala-Ala-Pro-Leu-4-nitroanilide + H2O
?
-
-
-
-
?
additional information
?
-
alpha-tubulin + H2O
?
direct alpha-tubulin proteolysis by granzyme M is complex and occurs at multiple cleavage sites, one of them being Leu at position 269. Granzyme M disturbs tubulin polymerization dynamics in vitro and induces microtubule network disorganization in tumor cells in vivo
-
-
?
alpha-tubulin + H2O
?
direct alpha-tubulin proteolysis by granzyme M is complex and occurs at multiple cleavage sites, one of them being Leu at position 269. Granzyme M disturbed tubulin polymerization dynamics in vitro and induced microtubule network disorganization in tumor cells in vivo
-
-
?
nucleophosmin + H2O
?
the nucleolar phosphoprotein, nucleophosmin (NPM), is cleaved and inactivated. Targeting of NPM by granzyme M may contribute to tumor cell eradication by abolishing NPM function
-
-
?
nucleophosmin + H2O
?
the nucleolar phosphoprotein, nucleophosmin (NPM), is cleaved and inactivated
-
-
?
inhibitor of caspase-activated DNase + H2O
?
-
-
-
-
?
inhibitor of caspase-activated DNase + H2O
?
-
direct degradation to release the nuclease activity of caspase-activated DNase for damaging DNA
-
-
?
poly(ADP-ribose) polymerase + H2O
?
-
-
-
-
?
poly(ADP-ribose) polymerase + H2O
?
-
cleavage to prevent cellular DNA repair and force apoptosis
-
-
?
Protein + H2O
?
-
-
-
?
additional information
?
-
the enzyme has a strong preference for Pro at the P2 position and Ala, Ser, or Asp at the P3 position
-
-
?
additional information
?
-
-
the enzyme has a strong preference for Pro at the P2 position and Ala, Ser, or Asp at the P3 position
-
-
?
additional information
?
-
isolated granzyme M induces cell death and disorganizes the microtubule network by targeting alpha-tubulin. Granzyme M inactivates the GzmB inhibitor protease inhibitor 9, thereby increasing the susceptibility of target cells to granzyme B-induced apoptosis
-
-
?
additional information
?
-
the recombinant GrM protein displays proteolytic activity only against a synthetic substrate that matches with the known cleavage specificity of the granzyme, which is after a Leu
-
-
?
additional information
?
-
-
the recombinant GrM protein displays proteolytic activity only against a synthetic substrate that matches with the known cleavage specificity of the granzyme, which is after a Leu
-
-
?
additional information
?
-
-
cleaves the carboxyl side of long narrow hydrophobic amino acids, such as methionine, but not large, bulky hydrophobic amino acids such as phenylalanine
-
?
additional information
?
-
-
hydrolyzes substrates containing a methionine-side chain at P1
-
?
additional information
?
-
-
participates in target cell death inflicted by cytotoxic lymphocytes
-
?
additional information
?
-
-
involved in granule exocytosis form of target cell death induced by cytotoxic lymphocytes
-
?
additional information
?
-
-
preference of proline over alanine at P2 and leucine over norleucine over methionine at P1, broad specificity at P3 and P4
-
-
?
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0.079 - 0.635
N-benzyloxycarbonyl-alanyl-alanyl-methionine-thiobenzylester
0.188 - 1.02
N-benzyloxycarbonyl-alanyl-alanyl-prolyl-methionine-thiobenzylester
0.267 - 0.695
N-benzyloxycarbonyl-alanyl-aspartyl-methionine-thiobenzylester
0.793 - 3.89
N-benzyloxycarbonyl-alanyl-lysyl-methionine-thiobenzylester
0.22 - 0.694
N-benzyloxycarbonyl-alanyl-prolyl-methionine-thiobenzylester
0.21 - 2.66
N-benzyloxycarbonyl-alanyl-seryl-methionine-thiobenzylester
0.418 - 0.441
N-benzyloxycarbonyl-aspartyl-prolyl-methionine-thiobenzylester
0.361 - 0.894
N-benzyloxycarbonyl-lysyl-prolyl-methionine-thiobenzylester
0.036 - 0.181
N-benzyloxycarbonyl-phenylalanyl-prolyl-methionine-thiobenzylester
0.0915 - 0.217
N-benzyloxycarbonyl-prolyl-prolyl-methionine-thiobenzylester
0.92 - 6.65
N-benzyloxycarbonyl-seryl-prolyl-methionine-thiobenzylester
0.0334 - 0.129
N2-Cbz-L-Asp(O-tBut)-L-Pro-L-Met thiobenzyl ester
0.0366 - 0.0423
N2-CBZ-O3-tBut-L-Ser-L-Pro-L-Met-SBzl
0.0263 - 0.083
N2-[(benzyloxy)carbonyl]-N6-(tert-butoxycarbonyl)-L-lysyl-L-prolyl-L-methionyl thiobenzyl ester
0.8
acetyl-KEPL-7-amido-4-methylcoumarin
-
-
2.4
acetyl-KEPM-7-amido-4-methylcoumarin
-
-
0.72
acetyl-KVAM-7-amido-4-methylcoumarin
-
-
0.37
acetyl-KVPL-7-amido-4-methylcoumarin
-
-
1.3
acetyl-KVPM-7-amido-4-methylcoumarin
-
-
0.4
acetyl-KYAL-7-amido-4-methylcoumarin
-
-
1
acetyl-KYPL-7-amido-4-methylcoumarin
-
-
2
acetyl-KYPM-7-amido-4-methylcoumarin
-
-
1.8
acetyl-MEPL-7-amido-4-methylcoumarin
-
-
1.5
acetyl-RYPL-7-amido-4-methylcoumarin
-
-
1.3
acetyl-VPL-7-amido-4-methylcoumarin
-
-
0.079
N-benzyloxycarbonyl-alanyl-alanyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
0.184
N-benzyloxycarbonyl-alanyl-alanyl-methionine-thiobenzylester
murine granzyme M without bovine serum albumin
0.635
N-benzyloxycarbonyl-alanyl-alanyl-methionine-thiobenzylester
-
0.188
N-benzyloxycarbonyl-alanyl-alanyl-prolyl-methionine-thiobenzylester
-
0.236
N-benzyloxycarbonyl-alanyl-alanyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
1.02
N-benzyloxycarbonyl-alanyl-alanyl-prolyl-methionine-thiobenzylester
murine granzyme M without bovine serum albumin
0.267
N-benzyloxycarbonyl-alanyl-aspartyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
0.695
N-benzyloxycarbonyl-alanyl-aspartyl-methionine-thiobenzylester
-
0.793
N-benzyloxycarbonyl-alanyl-lysyl-methionine-thiobenzylester
murine granzyme M without bovine serum albumin
3.89
N-benzyloxycarbonyl-alanyl-lysyl-methionine-thiobenzylester
-
0.22
N-benzyloxycarbonyl-alanyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
0.275
N-benzyloxycarbonyl-alanyl-prolyl-methionine-thiobenzylester
-
0.694
N-benzyloxycarbonyl-alanyl-prolyl-methionine-thiobenzylester
murine granzyme M without bovine serum albumin
0.21
N-benzyloxycarbonyl-alanyl-seryl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
1.3
N-benzyloxycarbonyl-alanyl-seryl-methionine-thiobenzylester
-
2.66
N-benzyloxycarbonyl-alanyl-seryl-methionine-thiobenzylester
murine granzyme M without bovine serum albumin
0.418
N-benzyloxycarbonyl-aspartyl-prolyl-methionine-thiobenzylester
-
0.441
N-benzyloxycarbonyl-aspartyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
0.361
N-benzyloxycarbonyl-lysyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
0.894
N-benzyloxycarbonyl-lysyl-prolyl-methionine-thiobenzylester
-
0.036
N-benzyloxycarbonyl-phenylalanyl-prolyl-methionine-thiobenzylester
-
0.181
N-benzyloxycarbonyl-phenylalanyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
0.0915
N-benzyloxycarbonyl-prolyl-prolyl-methionine-thiobenzylester
-
0.217
N-benzyloxycarbonyl-prolyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
0.92
N-benzyloxycarbonyl-seryl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
6.65
N-benzyloxycarbonyl-seryl-prolyl-methionine-thiobenzylester
-
0.0334
N2-Cbz-L-Asp(O-tBut)-L-Pro-L-Met thiobenzyl ester
-
0.129
N2-Cbz-L-Asp(O-tBut)-L-Pro-L-Met thiobenzyl ester
murine granzyme M with bovine serum albumin
0.0366
N2-CBZ-O3-tBut-L-Ser-L-Pro-L-Met-SBzl
murine granzyme M with bovine serum albumin
0.0423
N2-CBZ-O3-tBut-L-Ser-L-Pro-L-Met-SBzl
-
0.0263
N2-[(benzyloxy)carbonyl]-N6-(tert-butoxycarbonyl)-L-lysyl-L-prolyl-L-methionyl thiobenzyl ester
-
0.083
N2-[(benzyloxy)carbonyl]-N6-(tert-butoxycarbonyl)-L-lysyl-L-prolyl-L-methionyl thiobenzyl ester
murine granzyme M with bovine serum albumin
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2.46 - 10.8
N-benzyloxycarbonyl-alanyl-alanyl-methionine-thiobenzylester
13.1 - 30
N-benzyloxycarbonyl-alanyl-alanyl-prolyl-methionine-thiobenzylester
0.0903 - 0.438
N-benzyloxycarbonyl-alanyl-aspartyl-methionine-thiobenzylester
6.07 - 9.68
N-benzyloxycarbonyl-alanyl-lysyl-methionine-thiobenzylester
10.6 - 18.1
N-benzyloxycarbonyl-alanyl-prolyl-methionine-thiobenzylester
1.68 - 12.8
N-benzyloxycarbonyl-alanyl-seryl-methionine-thiobenzylester
17.3 - 29
N-benzyloxycarbonyl-aspartyl-prolyl-methionine-thiobenzylester
0.031 - 13.1
N-benzyloxycarbonyl-lysyl-prolyl-methionine-thiobenzylester
0.0784 - 6.08
N-benzyloxycarbonyl-phenylalanyl-prolyl-methionine-thiobenzylester
0.00785 - 6.08
N-benzyloxycarbonyl-prolyl-prolyl-methionine-thiobenzylester
0.26 - 255
N-benzyloxycarbonyl-seryl-prolyl-methionine-thiobenzylester
0.042 - 2.13
N2-Cbz-L-Asp(O-tBut)-L-Pro-L-Met thiobenzyl ester
0.0917 - 0.161
N2-CBZ-O3-tBut-L-Ser-L-Pro-L-Met-SBzl
0.03 - 0.335
N2-[(benzyloxy)carbonyl]-N6-(tert-butoxycarbonyl)-L-lysyl-L-prolyl-L-methionyl thiobenzyl ester
0.79
acetyl-KEPL-7-amido-4-methylcoumarin
-
-
0.42
acetyl-KEPM-7-amido-4-methylcoumarin
-
-
0.077
acetyl-KVAM-7-amido-4-methylcoumarin
-
-
0.7
acetyl-KVPL-7-amido-4-methylcoumarin
-
-
0.74
acetyl-KVPM-7-amido-4-methylcoumarin
-
-
0.06
acetyl-KYAL-7-amido-4-methylcoumarin
-
-
0.77
acetyl-KYPL-7-amido-4-methylcoumarin
-
-
0.115
acetyl-KYPM-7-amido-4-methylcoumarin
-
-
0.142
acetyl-MEPL-7-amido-4-methylcoumarin
-
-
0.22
acetyl-RYPL-7-amido-4-methylcoumarin
-
-
0.0044
acetyl-VPL-7-amido-4-methylcoumarin
-
-
2.46
N-benzyloxycarbonyl-alanyl-alanyl-methionine-thiobenzylester
murine granzyme M without bovine serum albumin
4.35
N-benzyloxycarbonyl-alanyl-alanyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
10.8
N-benzyloxycarbonyl-alanyl-alanyl-methionine-thiobenzylester
-
13.1
N-benzyloxycarbonyl-alanyl-alanyl-prolyl-methionine-thiobenzylester
-
16.1
N-benzyloxycarbonyl-alanyl-alanyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
30
N-benzyloxycarbonyl-alanyl-alanyl-prolyl-methionine-thiobenzylester
murine granzyme M without bovine serum albumin
0.0903
N-benzyloxycarbonyl-alanyl-aspartyl-methionine-thiobenzylester
-
0.438
N-benzyloxycarbonyl-alanyl-aspartyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
6.07
N-benzyloxycarbonyl-alanyl-lysyl-methionine-thiobenzylester
murine granzyme M without bovine serum albumin
9.68
N-benzyloxycarbonyl-alanyl-lysyl-methionine-thiobenzylester
-
10.6
N-benzyloxycarbonyl-alanyl-prolyl-methionine-thiobenzylester
-
12.3
N-benzyloxycarbonyl-alanyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
18.1
N-benzyloxycarbonyl-alanyl-prolyl-methionine-thiobenzylester
murine granzyme M without bovine serum albumin
1.68
N-benzyloxycarbonyl-alanyl-seryl-methionine-thiobenzylester
-
3.56
N-benzyloxycarbonyl-alanyl-seryl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
12.8
N-benzyloxycarbonyl-alanyl-seryl-methionine-thiobenzylester
murine granzyme M without bovine serum albumin
17.3
N-benzyloxycarbonyl-aspartyl-prolyl-methionine-thiobenzylester
-
29
N-benzyloxycarbonyl-aspartyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
0.031 - 0.51
N-benzyloxycarbonyl-lysyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
8.01
N-benzyloxycarbonyl-lysyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
13.1
N-benzyloxycarbonyl-lysyl-prolyl-methionine-thiobenzylester
-
0.0784
N-benzyloxycarbonyl-phenylalanyl-prolyl-methionine-thiobenzylester
-
0.634
N-benzyloxycarbonyl-phenylalanyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
6.08
N-benzyloxycarbonyl-phenylalanyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
0.00785
N-benzyloxycarbonyl-prolyl-prolyl-methionine-thiobenzylester
-
0.973
N-benzyloxycarbonyl-prolyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
6.08
N-benzyloxycarbonyl-prolyl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
0.26
N-benzyloxycarbonyl-seryl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
52.1
N-benzyloxycarbonyl-seryl-prolyl-methionine-thiobenzylester
murine granzyme M with bovine serum albumin
255
N-benzyloxycarbonyl-seryl-prolyl-methionine-thiobenzylester
-
0.042
N2-Cbz-L-Asp(O-tBut)-L-Pro-L-Met thiobenzyl ester
-
2.13
N2-Cbz-L-Asp(O-tBut)-L-Pro-L-Met thiobenzyl ester
murine granzyme M with bovine serum albumin
0.0917
N2-CBZ-O3-tBut-L-Ser-L-Pro-L-Met-SBzl
-
0.161
N2-CBZ-O3-tBut-L-Ser-L-Pro-L-Met-SBzl
murine granzyme M with bovine serum albumin
0.03
N2-[(benzyloxy)carbonyl]-N6-(tert-butoxycarbonyl)-L-lysyl-L-prolyl-L-methionyl thiobenzyl ester
-
0.335
N2-[(benzyloxy)carbonyl]-N6-(tert-butoxycarbonyl)-L-lysyl-L-prolyl-L-methionyl thiobenzyl ester
murine granzyme M with bovine serum albumin
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Smyth, M.J.; O'Connor, M.D.; Kelly, J.M.; Ganesvaran, P.; Thia, K.Y.; Trapani, J.A.
Expression of recombinant human Met-ase-1: a NK cell-specific granzyme
Biochem. Biophys. Res. Commun.
217
675-683
1995
Homo sapiens
brenda
Sattar, R.; Ali, S.A.; Abbasi, A.
Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling
Biochem. Biophys. Res. Commun.
308
726-735
2003
Homo sapiens
brenda
Smyth, M.J.; O'Connor, M.D.; Trapani, J.A.; Kershaw, M.H.; Brinkworth, R.I.
A novel substrate-binding pocket interaction restricts the specificity of the human NK cell-specific serine protease, Met-ase-1
J. Immunol.
156
4174-4181
1996
Homo sapiens
brenda
Bade, B.; Boettcher, H.E.; Lohrmann, J.; Hink-Schauer, C.; Bratke, K.; Jenne, D.E.; Virchow, J.C., Jr.; Luttmann, W.
Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes
Int. Immunol.
17
1419-1428
2005
Homo sapiens (P51124)
brenda
Rukamp, B.J.; Kam, C.M.; Natarajan, S.; Bolton, B.W.; Smyth, M.J.; Kelly, J.M.; Powers, J.C.
Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates
Arch. Biochem. Biophys.
422
9-22
2004
Homo sapiens (P51124), Homo sapiens, Rattus norvegicus (Q03238)
brenda
Kelly, J.M.; Waterhouse, N.J.; Cretney, E.; Browne, K.A.; Ellis, S.; Trapani, J.A.; Smyth, M.J.
Granzyme M mediates a novel form of perforin-dependent cell death
J. Biol. Chem.
279
22236-22242
2004
Homo sapiens
brenda
Mahrus, S.; Kisiel, W.; Craik, C.S.
Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B
J. Biol. Chem.
279
54275-54282
2004
Homo sapiens
brenda
Lu, H.; Hou, Q.; Zhao, T.; Zhang, H.; Zhang, Q.; Wu, L.; Fan, Z.
Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation
J. Immunol.
177
1171-1178
2006
Homo sapiens
brenda
Morice, W.G.; Jevremovic, D.; Hanson, C.A.
The expression of the novel cytotoxic protein granzyme M by large granular lymphocytic leukaemias of both T-cell and NK-cell lineage: an unexpected finding with implications regarding the pathobiology of these disorders
Br. J. Haematol.
137
237-239
2007
Homo sapiens
brenda
Hua, G.; Zhang, Q.; Fan, Z.
Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme M-mediated apoptosis
J. Biol. Chem.
282
20553-20560
2007
Homo sapiens (P51124)
brenda
Cullen, S.P.; Afonina, I.S.; Donadini, R.; Luethi, A.U.; Medema, J.P.; Bird, P.I.; Martin, S.J.
Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing
J. Biol. Chem.
284
5137-5147
2009
Homo sapiens (P51124), Homo sapiens
brenda
Bovenschen, N.; de Koning, P.J.; Quadir, R.; Broekhuizen, R.; Damen, J.M.; Froelich, C.J.; Slijper, M.; Kummer, J.A.
NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network
J. Immunol.
180
8184-8191
2008
Homo sapiens (P51124), Homo sapiens
brenda
Wu, L.; Wang, L.; Hua, G.; Liu, K.; Yang, X.; Zhai, Y.; Bartlam, M.; Sun, F.; Fan, Z.
Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M
J. Immunol.
183
421-429
2009
Homo sapiens (P51124), Homo sapiens
brenda
Froelich, C.J.; Pardo, J.; Simon, M.M.
Granule-associated serine proteases: granzymes might not just be killer proteases
Trends Immunol.
30
117-123
2009
Mus musculus (O08643), Homo sapiens (P51124), Rattus norvegicus (Q03238)
brenda
Hu, D.; Liu, S.; Shi, L.; Li, C.; Wu, L.; Fan, Z.
Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells
J. Biol. Chem.
285
18326-18335
2010
Homo sapiens (P51124)
brenda
Khurshid, R.; Saleem, M.; Akhtar, M.S.; Salim, A.
Granzyme M: Characterization with sites of post-translational modification and specific sites of interaction with substrates and inhibitors
Mol. Biol. Rep.
392
199-207
2010
Homo sapiens (P51124), Homo sapiens
brenda
de Koning, P.J.; Tesselaar, K.; Bovenschen, N.; Colak, S.; Quadir, R.; Volman, T.J.; Kummer, J.A.
The cytotoxic protease granzyme M is expressed by lymphocytes of both the innate and adaptive immune system
Mol. Immunol.
47
903-911
2010
Homo sapiens (P51124), Homo sapiens
brenda
De Poot, S.; Lai, K.; Hovingh, E.; Bovenschen, N.
Granzyme M cannot induce cell death via cleavage of mouse FADD
Apoptosis
18
533-534
2013
Homo sapiens (P51124), Mus musculus (O08643), Mus musculus
brenda
Schiffer, S.; Letzian, S.; Jost, E.; Mladenov, R.; Hristodorov, D.; Huhn, M.; Fischer, R.; Barth, S.; Thepen, T.
Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells
Cancer Lett.
341
178-185
2013
Homo sapiens (P51124), Homo sapiens
brenda
van Domselaar, R.; de Poot, S.A.; Remmerswaal, E.B.; Lai, K.W.; ten Berge, I.J.; Bovenschen, N.
Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication
Cell Death Differ.
20
419-429
2013
Homo sapiens (P51124), Homo sapiens
brenda
de Poot, S.A.; Lai, K.W.; van der Wal, L.; Plasman, K.; Van Damme, P.; Porter, A.C.; Gevaert, K.; Bovenschen, N.
Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis
Cell Death Differ.
21
416-426
2014
Homo sapiens (P51124), Homo sapiens
brenda
Souza-Fonseca-Guimaraes, F.; Krasnova, Y.; Putoczki, T.; Miles, K.; MacDonald, K.P.; Town, L.; Shi, W.; Gobe, G.C.; McDade, L.; Mielke, L.A.; Tye, H.; Masters, S.L.; Belz, G.T.; Huntington, N.D.; Radford-Smith, G.; Smyth, M.J.
Granzyme M has a critical role in providing innate immune protection in ulcerative colitis
Cell Death Dis.
7
e2302
2016
Homo sapiens (P51124), Homo sapiens
brenda
Wensink, A.C.; Wiewel, M.A.; Jongeneel, L.H.; Boes, M.; van der Poll, T.; Hack, C.E.; Bovenschen, N.
Granzyme M and K release in human experimental endotoxemia
Immunobiology
221
773-777
2016
Homo sapiens (P51124), Homo sapiens
brenda
Wang, H.; Sun, Q.; Wu, Y.; Wang, L.; Zhou, C.; Ma, W.; Zhang, Y.; Wang, S.; Zhang, S.
Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation
Oncotarget
6
5818-5831
2015
Homo sapiens (P51124), Homo sapiens, Mus musculus (O08643), Mus musculus
brenda