Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.4.21.B2 - granzyme M

for references in articles please use BRENDA:EC3.4.21.B2
preliminary BRENDA-supplied EC number
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B2 granzyme M
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
UNIPROT: O08643
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
endopeptidase activity. Cleaves substrates containing a methionine side chain at P1
Synonyms
granzyme m, met-ase-1, gzm m, hgzmm, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CAS REGISTRY NUMBER
COMMENTARY hide
159745-66-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
human Fas-associated protein with Death Domain + H2O
?
show the reaction diagram
-
cleavage at residue Met196
-
?
mouse Fas-associated protein with Death Domain mutant V193M/L194S + H2O
?
show the reaction diagram
no substrate: wild-type mouse Fas-associated protein with Death Domain lacking a residue corresponding to Met196 of the human substrate
cleavage at residue M193
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
granzyme M induces the epithelial mesenchymal transition in cancer cells associated with STAT3 activation. It increases chemoresistance, colony formation, cytokine secretion and invasiveness
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
O08643_MOUSE
264
0
29122
TrEMBL
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Froelich, C.J.; Pardo, J.; Simon, M.M.
Granule-associated serine proteases: granzymes might not just be killer proteases
Trends Immunol.
30
117-123
2009
Mus musculus (O08643), Homo sapiens (P51124), Rattus norvegicus (Q03238)
Manually annotated by BRENDA team
De Poot, S.; Lai, K.; Hovingh, E.; Bovenschen, N.
Granzyme M cannot induce cell death via cleavage of mouse FADD
Apoptosis
18
533-534
2013
Homo sapiens (P51124), Mus musculus (O08643), Mus musculus
Manually annotated by BRENDA team
Wang, H.; Sun, Q.; Wu, Y.; Wang, L.; Zhou, C.; Ma, W.; Zhang, Y.; Wang, S.; Zhang, S.
Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation
Oncotarget
6
5818-5831
2015
Homo sapiens (P51124), Homo sapiens, Mus musculus (O08643), Mus musculus
Manually annotated by BRENDA team