Reference on EC 3.4.21.B10 - neurosin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Mus musculus (P15947), Homo sapiens (Q92876)
Yousef, G.M.; Diamandis, E.P.
The new human tissue kallikrein gene family: structure, function, and association to disease
Endocr. Rev.
22
184-204
2001
Homo sapiens (Q92876)
Pampalakis, G.; Kurlender, L.; Diamandis, E.P.; Sotiropoulou, G.
Cloning and characterization of novel isoforms of the human kallikrein 6 gene
Biochem. Biophys. Res. Commun.
320
54-61
2004
Homo sapiens (Q92876), Homo sapiens
Bayes, A.; Tsetsenis, T.; Ventura, S.; Vendrell, J.; Aviles, F.X.; Sotiropoulou, G.
Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation/inactivation
Biol. Chem.
385
517-524
2004
Homo sapiens
Prezas, P.; Arlt, M.J.; Viktorov, P.; Soosaipillai, A.; Holzscheiter, L.; Schmitt, M.; Talieri, M.; Diamandis, E.P.; Krueger, A.; Magdolen, V.
Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells
Biol. Chem.
387
807-811
2006
Homo sapiens
Ni, X.; Zhang, W.; Huang, K.C.; Wang, Y.; Ng, S.K.; Mok, S.C.; Berkowitz, R.S.; Ng, S.W.
Characterisation of human kallikrein 6/protease M expression in ovarian cancer
Br. J. Cancer
91
725-731
2004
Homo sapiens
Yamaguchi, N.
Neurosin or human kallikrein 6
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
2
1585-1587
2004
Homo sapiens, Mus musculus, Rattus norvegicus
-
Darling, M.R.; Jackson-Boeters, L.; Daley, T.D.; Diamandis, E.P.
Human kallikrein 6 expression in salivary gland tumors
J. Histochem. Cytochem.
54
337-342
2006
Homo sapiens
Blaber, S.I.; Yoon, H.; Scarisbrick, I.A.; Juliano, M.A.; Blaber, M.
The autolytic regulation of human kallikrein-related peptidase 6
Biochemistry
46
5209-5217
2007
Homo sapiens
Pampalakis, G.; Sotiropoulou, G.
Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer
Biol. Chem.
387
773-782
2006
Homo sapiens (Q92876), Homo sapiens
Shan, S.J.; Scorilas, A.; Katsaros, D.; Diamandis, E.P.
Transcriptional upregulation of human tissue kallikrein 6 in ovarian cancer: clinical and mechanistic aspects
Br. J. Cancer
96
362-372
2007
Homo sapiens (Q92876), Homo sapiens
Klucky, B.; Mueller, R.; Vogt, I.; Teurich, S.; Hartenstein, B.; Breuhahn, K.; Flechtenmacher, C.; Angel, P.; Hess, J.
Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion
Cancer Res.
67
8198-8206
2007
Mus musculus, Homo sapiens (Q92876), Homo sapiens
Singh, J.; Naran, A.; Misso, N.L.; Rigby, P.J.; Thompson, P.J.; Bhoola, K.D.
Expression of kallikrein-related peptidases (KRP/hK5, 7, 6, 8) in subtypes of human lung carcinoma
Int. Immunopharmacol.
8
300-306
2008
Homo sapiens
Debela, M.; Magdolen, V.; Schechter, N.; Valachova, M.; Lottspeich, F.; Craik, C.S.; Choe, Y.; Bode, W.; Goettig, P.
Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences
J. Biol. Chem.
281
25678-25688
2006
Homo sapiens (Q92876)
Angelo, P.F.; Lima, A.R.; Alves, F.M.; Blaber, S.I.; Scarisbrick, I.A.; Blaber, M.; Juliano, L.; Juliano, M.A.
Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects
J. Biol. Chem.
281
3116-3126
2006
Homo sapiens
Henkhaus, R.S.; Roy, U.K.; Cavallo-Medved, D.; Sloane, B.F.; Gerner, E.W.; Ignatenko, N.A.
Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells
Neoplasia
10
140-148
2008
Homo sapiens
Bando, Y.; Ito, S.; Nagai, Y.; Terayama, R.; Kishibe, M.; Jiang, Y.P.; Mitrovic, B.; Takahashi, T.; Yoshida, S.
Implications of protease M/neurosin in myelination during experimental demyelination and remyelination
Neurosci. Lett.
405
175-180
2006
Mus musculus, Mus musculus BALB/c
Luo, L.; Soosaipillai, A.; Grass, L.; Diamandis, E.P.
Characterization of human kallikreins 6 and 10 in ascites fluid from ovarian cancer patients
Tumour Biol.
27
227-234
2006
Homo sapiens
Debela, M.; Beaufort, N.; Magdolen, V.; Schechter, N.M.; Craik, C.S.; Schmitt, M.; Bode, W.; Goettig, P.
Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7
Biol. Chem.
389
623-632
2008
Homo sapiens, Homo sapiens (Q92876)
Pampalakis, G.; Arampatzidou, M.; Amoutzias, G.; Kossida, S.; Sotiropoulou, G.
Identification and analysis of mammalian KLK6 orthologue genes for prediction of physiological substrates
Comput. Biol. Chem.
32
111-121
2008
Canis lupus familiaris, Macaca mulatta, Mus musculus, Pan troglodytes, Rattus norvegicus, Sus scrofa, Bos taurus (A6QQ95), Bos taurus, Homo sapiens (Q92876), Homo sapiens
Oikonomopoulou, K.; Hansen, K.K.; Saifeddine, M.; Tea, I.; Blaber, M.; Blaber, S.I.; Scarisbrick, I.; Andrade-Gordon, P.; Cottrell, G.S.; Bunnett, N.W.; Diamandis, E.P.; Hollenberg, M.D.
Proteinase-activated receptors, targets for kallikrein signaling
J. Biol. Chem.
281
32095-32112
2006
Homo sapiens (Q92876)
Li, H.X.; Hwang, B.Y.; Laxmikanthan, G.; Blaber, S.I.
Blaber, M.; Golubkov, P.A.; Ren, P.; Iverson, B.L.; Georgiou, G.: Substrate specificity of human kallikreins 1 and 6 determined by phage display
Protein Sci.
17
664-672
2008
Homo sapiens (Q92876)
Pampalakis, G.; Prosnikli, E.; Agalioti, T.; Vlahou, A.; Zoumpourlis, V.; Sotiropoulou, G.
A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition
Cancer Res.
69
3779-3787
2009
Homo sapiens (Q92876), Homo sapiens
Tatebe, H.; Watanabe, Y.; Kasai, T.; Mizuno, T.; Nakagawa, M.; Tanaka, M.; Tokuda, T.
Extracellular neurosin degrades alpha-synuclein in cultured cells
Neurosci. Res.
67
341-346
2010
Homo sapiens
Krenzer, S.; Peterziel, H.; Mauch, C.; Blaber, S.I.; Blaber, M.; Angel, P.; Hess, J.
Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment
J. Invest. Dermatol.
131
2281-2288
2011
Homo sapiens
Scarisbrick, I.A.; Epstein, B.; Cloud, B.A.; Yoon, H.; Wu, J.; Renner, D.N.; Blaber, S.I.; Blaber, M.; Vandell, A.G.; Bryson, A.L.
Functional role of kallikrein 6 in regulating immune cell survival
PLoS ONE
6
e18376
2011
Homo sapiens, Mus musculus
Scarisbrick, I.A.; Radulovic, M.; Burda, J.E.; Larson, N.; Blaber, S.I.; Giannini, C.; Blaber, M.; Vandell, A.G.
Kallikrein 6 is a novel molecular trigger of reactive astrogliosis
Biol. Chem.
393
355-367
2012
Mus musculus
Seiz, L.; Dorn, J.; Kotzsch, M.; Walch, A.; Grebenchtchikov, N.I.; Gkazepis, A.; Schmalfeldt, B.; Kiechle, M.; Bayani, J.; Diamandis, E.P.; Langer, R.; Sweep, F.C.; Schmitt, M.; Magdolen, V.
Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients
Biol. Chem.
393
391-401
2012
Homo sapiens (Q92876), Homo sapiens
Vakrakou, A.; Devetzi, M.; Papachristopoulou, G.; Malachias, A.; Scorilas, A.; Xynopoulos, D.; Talieri, M.
Kallikrein-related peptidase 6 (KLK6) expression in the progression of colon adenoma to carcinoma
Biol. Chem.
395
1105-1117
2014
Homo sapiens (Q92876), Homo sapiens
Liang, G.; Chen, X.; Aldous, S.; Pu, S.F.; Mehdi, S.; Powers, E.; Xia, T.; Wang, R.
Human kallikrein 6 inhibitors with a para-amidobenzylanmine P1 group identified through virtual screening
Bioorg. Med. Chem. Lett.
22
2450-2455
2012
Homo sapiens (Q92876), Homo sapiens
Scarisbrick, I.A.; Yoon, H.; Panos, M.; Larson, N.; Blaber, S.I.; Blaber, M.; Rodriguez, M.
Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis
Brain Pathol.
22
709-722
2012
Mus musculus, Homo sapiens (Q92876), Mus musculus SJL/J
Zhang, Y.; Zhang, Z.; Yang, L.; Xu, B.; Li, W.; Tang, P.; Zhang, Z.; Han, N.; Gao, Y.; Cheng, S.; Xiao, T.
Identification of human tissue kallikrein 6 as a potential marker of laryngeal cancer based on the relevant secretory/releasing protein database
Dis. Markers
2014
594093
2014
Homo sapiens (Q92876), Homo sapiens
Grin, A.; Samaan, S.; Tripathi, M.; Rotondo, F.; Kovacs, K.; Bassily, M.N.; Yousef, G.M.
Evaluation of human tissue kallikrein-related peptidases 6 and 10 expression in early gastroesophageal adenocarcinoma
Hum. Pathol.
46
541-548
2015
Homo sapiens (Q92876), Homo sapiens
Yoon, H.; Radulovic, M.; Wu, J.; Blaber, S.I.; Blaber, M.; Fehlings, M.G.; Scarisbrick, I.A.
Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity
J. Neurochem.
127
283-298
2013
Mus musculus, Mus musculus C57/BL6J
Talieri, M.; Zoma, M.; Devetzi, M.; Scorilas, A.; Ardavanis, A.
Kallikrein-related peptidase 6 (KLK6) gene expression in intracranial tumors
Tumour Biol.
33
1375-1383
2012
Homo sapiens (Q92876), Homo sapiens
Kim, J.J.; Kim, J.T.; Yoon, H.R.; Kang, M.A.; Kim, J.H.; Lee, Y.H.; Kim, J.W.; Lee, S.J.; Song, E.Y.; Myung, P.K.; Lee, H.G.
Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer
Tumour Biol.
33
731-738
2012
Homo sapiens (Q92876), Homo sapiens
Silva, R.N.; Oliveira, L.C.G.; Parise, C.B.; Oliveira, J.R.; Severino, B.; Corvino, A.; di Vaio, P.; Temussi, P.A.; Caliendo, G.; Santagada, V.; Juliano, L.; Juliano, M.A.
Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease?
Biochim. Biophys. Acta
1865
558-564
2017
Homo sapiens (Q92876), Homo sapiens
Yoon, H.; Scarisbrick, I.A.
Kallikrein-related peptidase 6 exacerbates disease in an autoimmune model of multiple sclerosis
Biol. Chem.
397
1277-1286
2016
Mus musculus
Yoon, H.; Radulovic, M.; Scarisbrick, I.A.
Kallikrein-related peptidase 6 orchestrates astrocyte form and function through proteinase activated receptor-dependent mechanisms
Biol. Chem.
399
1041-1052
2018
Mus musculus
Santos, J.A.; Kondo, M.Y.; Freitas, R.F.; dos Santos, M.H.; Ramalho, T.C.; Assis, D.M.; Juliano, L.; Juliano, M.A.; Puzer, L.
The natural flavone fukugetin as a mixed-type inhibitor for human tissue kallikreins
Bioorg. Med. Chem. Lett.
26
1485-1489
2016
Homo sapiens
Korbakis, D.; Soosaipillai, A.; Diamandis, E.P.
Study of kallikrein-related peptidase 6 (KLK6) and its complex with alpha1-antitrypsin in biological fluids
Clin. Chem. Lab. Med.
55
1385-1396
2017
Homo sapiens (Q92876), Homo sapiens
Sananes, A.; Cohen, I.; Shahar, A.; Hockla, A.; De Vita, E.; Miller, A.K.; Radisky, E.S.; Papo, N.
A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering
J. Biol. Chem.
293
12663-12680
2018
Homo sapiens (Q92876), Homo sapiens
Schrader, C.H.; Kolb, M.; Zaoui, K.; Flechtenmacher, C.; Grabe, N.; Weber, K.J.; Hielscher, T.; Plinkert, P.K.; Hess, J.
Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients
Mol. Cancer
14
107
2015
Homo sapiens (Q92876), Homo sapiens
Spencer, B.; Valera, E.; Rockenstein, E.; Trejo-Morales, M.; Adame, A.; Masliah, E.
A brain-targeted, modified neurosin (kallikrein-6) reduces alpha-synuclein accumulation in a mouse model of multiple system atrophy
Mol. Neurodegener.
10
48
2015
Mus musculus (Q91Y82), Mus musculus
Kishibe, M.; Baida, G.; Bhalla, P.; Lavker, R.M.; Schlosser, B.; Iinuma, S.; Yoshida, S.; Dudley, J.T.; Budunova, I.
Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids
Oncotarget
7
69479-69488
2016
Mus musculus
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