Disease on EC 3.4.21.B10 - neurosin
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Adenocarcinoma
Evaluation of human tissue kallikrein-related peptidases 6 and 10 expression in early gastroesophageal adenocarcinoma.
Adenocarcinoma
Kallikrein-Related Peptidase 6 Is Associated with the Tumour Microenvironment of Pancreatic Ductal Adenocarcinoma.
Adenoma
Kallikrein-related peptidase 6 (KLK6) expression in the progression of colon adenoma to carcinoma.
Alzheimer Disease
Accumulation of ?-synuclein in dementia with Lewy bodies is associated with decline in the ?-synuclein-degrading enzymes kallikrein-6 and calpain-1.
Alzheimer Disease
Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease.
Alzheimer Disease
Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease.
Alzheimer Disease
Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients.
Alzheimer Disease
Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia.
Alzheimer Disease
Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease.
Alzheimer Disease
One round of SELEX for the generation of DNA aptamers directed against KLK6.
Alzheimer Disease
Plasmatic level of neurosin predicts outcome of mild cognitive impairment.
Alzheimer Disease
Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)-antichymotrypsin.
Alzheimer Disease
Trypsin and trypsin-like proteases in the brain: proteolysis and cellular functions.
Alzheimer Disease
Value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease.
Barrett Esophagus
Evaluation of human tissue kallikrein-related peptidases 6 and 10 expression in early gastroesophageal adenocarcinoma.
Brain Injuries, Traumatic
Kallikrein-related peptidase 6: a biomarker for traumatic brain injury in the rat.
Breast Neoplasms
A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition.
Breast Neoplasms
An integrated cell line-based discovery strategy identified follistatin and kallikrein 6 as serum biomarker candidates of breast carcinoma.
Breast Neoplasms
Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance.
Breast Neoplasms
Kallikrein-related peptidase 6 (KLK6) expression differentiates tumor subtypes and predicts clinical outcome in breast cancer patients.
Breast Neoplasms
Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer.
Carcinogenesis
Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein.
Carcinoma
Copy number and expression alterations of miRNAs in the ovarian cancer cell line OVCAR-3: impact on kallikrein 6 protein expression.
Carcinoma
Differential roles of kallikrein-related peptidase 6 in malignant transformation and ?Np63?-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma.
Carcinoma
Human kallikrein 6 (hK6): a new potential serum biomarker for diagnosis and prognosis of ovarian carcinoma.
Carcinoma
Human kallikrein 6 (zyme/protease M/neurosin): a new serum biomarker of ovarian carcinoma.
Carcinoma
Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells.
Carcinoma
Kallikrein-related peptidase 6 (KLK6) expression in the progression of colon adenoma to carcinoma.
Carcinoma
Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients.
Carcinoma, Endometrioid
Human kallikrein 6: a new potential serum biomarker for uterine serous papillary cancer.
Carcinoma, Non-Small-Cell Lung
High Kallikrein-Related Peptidase 6 in Non-Small Cell Lung Cancer Cells: an indicator of tumor proliferation and poor prognosis.
Carcinoma, Ovarian Epithelial
Cancer antigen 125, human epididymis 4, kallikrein 6, osteopontin and soluble mesothelin-related peptide immunocomplexed with immunoglobulin M in epithelial ovarian cancer diagnosis.
Carcinoma, Ovarian Epithelial
KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma.
Carcinoma, Squamous Cell
Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients.
Chickenpox
Kallikrein-6-Regulated Pathways Shed Light on New Potential Targets in Varicella Zoster Virus Infection.
Colonic Neoplasms
Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells.
Colonic Neoplasms
Specific microRNA-mRNA Regulatory Network of Colon Cancer Invasion Mediated by Tissue Kallikrein-Related Peptidase 6.
Colonic Neoplasms
Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer.
Colorectal Neoplasms
Evaluation and prognostic significance of human tissue kallikrein-related peptidase 6 (KLK6) in colorectal cancer.
Colorectal Neoplasms
Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein.
Colorectal Neoplasms
Lymph node tissue kallikrein-related peptidase 6 mRNA: a progression marker for colorectal cancer.
Colorectal Neoplasms
Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer.
Dementia
A brain-targeted, modified neurosin (kallikrein-6) reduces ?-synuclein accumulation in a mouse model of multiple system atrophy.
Dementia
Accumulation of ?-synuclein in dementia with Lewy bodies is associated with decline in the ?-synuclein-degrading enzymes kallikrein-6 and calpain-1.
Dementia
Lentivirus Mediated Delivery of Neurosin Promotes Clearance of Wild-type ?-Synuclein and Reduces the Pathology in an ?-Synuclein Model of LBD.
Dementia
Low CSF levels of both ?-synuclein and the ?-synuclein cleaving enzyme neurosin in patients with synucleinopathy.
Dementia
The role of human kallikrein 6, clusterin and adiponectin as potential blood biomarkers of dementia.
Dementia
Value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease.
Dementia, Vascular
Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia.
Dementia, Vascular
Value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease.
Demyelinating Diseases
Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease?
Demyelinating Diseases
Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system.
Demyelinating Diseases
Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease.
Demyelinating Diseases
Kallikrein 6 Regulates Early CNS Demyelination in a Viral Model of Multiple Sclerosis.
Demyelinating Diseases
Kallikrein-related peptidase 6: a biomarker for traumatic brain injury in the rat.
Demyelinating Diseases
Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects.
Encephalomyelitis
In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins.
Encephalomyelitis
Kallikrein 6 secreted by oligodendrocytes regulates the progression of experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins.
Encephalomyelitis, Autoimmune, Experimental
Kallikrein 6 secreted by oligodendrocytes regulates the progression of experimental autoimmune encephalomyelitis.
Endometriosis
CD44, TGM2 and EpCAM as novel plasma markers in endometrial cancer diagnosis.
Glioblastoma
Clinical significance and novel mechanism of action of kallikrein 6 in glioblastoma.
Herpes Zoster
Kallikrein-6-Regulated Pathways Shed Light on New Potential Targets in Varicella Zoster Virus Infection.
Laryngeal Neoplasms
Identification of human tissue kallikrein 6 as a potential marker of laryngeal cancer based on the relevant secretory/releasing protein database.
Lung Neoplasms
Growth and survival of lung cancer cells: regulation by kallikrein-related peptidase 6 via activation of proteinase-activated receptor 2 and the epidermal growth factor receptor.
Lung Neoplasms
High Kallikrein-Related Peptidase 6 in Non-Small Cell Lung Cancer Cells: an indicator of tumor proliferation and poor prognosis.
Melanoma
Cell adhesion and communication proteins are differentially expressed in melanoma progression model.
Melanoma
Expression and Function of the Kallikrein-Related Peptidase 6 in the Human Melanoma Microenvironment.
Melanoma
Expression of Kallikrein-Related Peptidase 6 in Primary Mucosal Malignant Melanoma of the Head and Neck.
Multiple Sclerosis
Differential expression of multiple kallikreins in a viral model of multiple sclerosis points to unique roles in the innate and adaptive immune response.
Multiple Sclerosis
Human kallikrein 6 cerebrospinal levels are elevated in multiple sclerosis.
Multiple Sclerosis
Kallikrein 6 Regulates Early CNS Demyelination in a Viral Model of Multiple Sclerosis.
Multiple Sclerosis
Kallikrein-related peptidase 6 exacerbates disease in an autoimmune model of multiple sclerosis.
Multiple Sclerosis
Trypsin and trypsin-like proteases in the brain: proteolysis and cellular functions.
Multiple System Atrophy
A brain-targeted, modified neurosin (kallikrein-6) reduces ?-synuclein accumulation in a mouse model of multiple system atrophy.
Multiple System Atrophy
Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of ?-synuclein in multiple system atrophy.
Neoplasm Metastasis
Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein.
Neoplasm Metastasis
Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer.
Neoplasm, Residual
Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker.
Neoplasms
A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
Neoplasms
A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition.
Neoplasms
Cancer antigen 125, human epididymis 4, kallikrein 6, osteopontin and soluble mesothelin-related peptide immunocomplexed with immunoglobulin M in epithelial ovarian cancer diagnosis.
Neoplasms
Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells.
Neoplasms
Correlation of hK6 expression with tumor recurrence and prognosis in advanced gastric cancer.
Neoplasms
Development of Monoclonal Antibodies and Characterization of an ELISA Platform Against Kallikrein-Related Peptidase 6 as a Tumor Biomarker.
Neoplasms
Effects of a phytoestrogen-containing soy extract on the growth-inhibitory activity of ICI 182 780 in an experimental model of estrogen-dependent breast cancer.
Neoplasms
Expression and Function of the Kallikrein-Related Peptidase 6 in the Human Melanoma Microenvironment.
Neoplasms
Expression of Kallikrein-Related Peptidase 6 in Primary Mucosal Malignant Melanoma of the Head and Neck.
Neoplasms
Growth and survival of lung cancer cells: regulation by kallikrein-related peptidase 6 via activation of proteinase-activated receptor 2 and the epidermal growth factor receptor.
Neoplasms
High Kallikrein-Related Peptidase 6 in Non-Small Cell Lung Cancer Cells: an indicator of tumor proliferation and poor prognosis.
Neoplasms
Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance.
Neoplasms
Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells.
Neoplasms
Human kallikrein 6: a new potential serum biomarker for uterine serous papillary cancer.
Neoplasms
Identification and analysis of mammalian KLK6 orthologue genes for prediction of physiological substrates.
Neoplasms
Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker.
Neoplasms
Insights into the activity control of the kallikrein-related peptidase 6: small-molecule modulators and allosterism.
Neoplasms
Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells.
Neoplasms
Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein.
Neoplasms
Kallikrein-related peptidase 6 (KLK6) expression differentiates tumor subtypes and predicts clinical outcome in breast cancer patients.
Neoplasms
Kallikrein-Related Peptidase 6 Is Associated with the Tumour Microenvironment of Pancreatic Ductal Adenocarcinoma.
Neoplasms
Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients.
Neoplasms
Lack of stimulatory activity of a phytoestrogen-containing soy extract on the growth of breast cancer tumors in mice.
Neoplasms
Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer.
Neoplasms
Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer.
Neoplasms
Reference intervals and biological variation for kallikrein 6: influence of age and renal failure.
Neoplasms
Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.
Neoplasms
Silencing of kallikrein-related peptidase 6 attenuates the proliferation, migration, and invasion of gastric cancer cells through inhibition of epithelial-mesenchymal transition.
Neoplasms
The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family.
Neoplasms
Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer.
Neoplasms
Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer.
Neurobehavioral Manifestations
Value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease.
Neurodegenerative Diseases
Insights into the activity control of the kallikrein-related peptidase 6: small-molecule modulators and allosterism.
Neurodegenerative Diseases
One round of SELEX for the generation of DNA aptamers directed against KLK6.
Neurodegenerative Diseases
Reference intervals and biological variation for kallikrein 6: influence of age and renal failure.
Neurodegenerative Diseases
Trypsin and trypsin-like proteases in the brain: proteolysis and cellular functions.
Neuroinflammatory Diseases
Kallikrein-related peptidase 6: a biomarker for traumatic brain injury in the rat.
Nevus
Cell adhesion and communication proteins are differentially expressed in melanoma progression model.
Ovarian Neoplasms
Characterisation of human kallikrein 6/protease M expression in ovarian cancer.
Ovarian Neoplasms
Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer.
Ovarian Neoplasms
Cloning and characterization of novel isoforms of the human kallikrein 6 gene.
Ovarian Neoplasms
Copy number and expression alterations of miRNAs in the ovarian cancer cell line OVCAR-3: impact on kallikrein 6 protein expression.
Ovarian Neoplasms
Diagnostic value of KLK6 as an ovarian cancer biomarker: A meta-analysis.
Ovarian Neoplasms
Differential N-glycosylation of kallikrein 6 derived from ovarian cancer cells or the central nervous system.
Ovarian Neoplasms
Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation/inactivation.
Ovarian Neoplasms
Identification and analysis of mammalian KLK6 orthologue genes for prediction of physiological substrates.
Ovarian Neoplasms
Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker.
Ovarian Neoplasms
Potential markers that complement expression of CA125 in epithelial ovarian cancer.
Ovarian Neoplasms
Prognostic value of kallikrein-related peptidase 6 protein expression levels in advanced ovarian cancer evaluated by automated quantitative analysis (AQUA).
Ovarian Neoplasms
Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)-antichymotrypsin.
Ovarian Neoplasms
Separation of kallikrein 6 glycoprotein subpopulations in biological fluids by anion-exchange chromatography coupled to ELISA and identification by mass spectrometry.
Ovarian Neoplasms
Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients.
Ovarian Neoplasms
Transcriptional upregulation of human tissue kallikrein 6 in ovarian cancer: clinical and mechanistic aspects.
Ovarian Neoplasms
Validation of a Novel Biomarker Panel for the Detection of Ovarian Cancer.
Parkinson Disease
A brain-targeted, modified neurosin (kallikrein-6) reduces ?-synuclein accumulation in a mouse model of multiple system atrophy.
Parkinson Disease
Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro.
Parkinson Disease
Lentivirus Mediated Delivery of Neurosin Promotes Clearance of Wild-type ?-Synuclein and Reduces the Pathology in an ?-Synuclein Model of LBD.
Parkinson Disease
Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease.
Parkinson Disease
Low CSF levels of both ?-synuclein and the ?-synuclein cleaving enzyme neurosin in patients with synucleinopathy.
Parkinson Disease
Trypsin and trypsin-like proteases in the brain: proteolysis and cellular functions.
Peripheral Nervous System Diseases
Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease.
Prostatic Neoplasms
Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer.
Prostatic Neoplasms
RE: Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer.
Renal Insufficiency
Reference intervals and biological variation for kallikrein 6: influence of age and renal failure.
Spinal Cord Injuries
In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins.
Squamous Cell Carcinoma of Head and Neck
Differential roles of kallikrein-related peptidase 6 in malignant transformation and ?Np63?-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients.
Stomach Neoplasms
Clinicopathologic and biological significance of kallikrein 6 overexpression in human gastric cancer.
Stomach Neoplasms
Correlation of hK6 expression with tumor recurrence and prognosis in advanced gastric cancer.
Stomach Neoplasms
Expression and biological significance of human kallikrein 6 in gastric cancer tissues.
Stomach Neoplasms
Kallikrein-related peptidase 6 induces chemotherapeutic resistance by attenuating auranofin-induced cell death through activation of autophagy in gastric cancer.
Stomach Neoplasms
Silencing of kallikrein-related peptidase 6 attenuates the proliferation, migration, and invasion of gastric cancer cells through inhibition of epithelial-mesenchymal transition.
Stomach Neoplasms
Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer.
Stomach Ulcer
Expression and biological significance of human kallikrein 6 in gastric cancer tissues.
Subarachnoid Hemorrhage
Kallikrein 6 as a serum prognostic marker in patients with aneurysmal subarachnoid hemorrhage.
Synucleinopathies
Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies.
Synucleinopathies
Low CSF levels of both ?-synuclein and the ?-synuclein cleaving enzyme neurosin in patients with synucleinopathy.
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