Reference on EC 3.4.21.93 - Proprotein convertase 1
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Steiner, D.F.; Smeekens, S.P.; Ohagi, S.; Chan, S.J.
The new enzymology of precursor processing endoproteases
J. Biol. Chem.
267
23435-23438
1992
Homo sapiens, Mus musculus
Wuthrich, M.; Creemers, J.W.M.; van de Ven, W.J.M.; Sterchi, E.E.
Human lactase-phlorizin hydrolase is not processed by furin, PC1/PC3, PC2, PACE4 and PC5/PC6A of the family of subtilisin-like proprotein processing proteases
Biochim. Biophys. Acta
1311
199-203
1996
Homo sapiens, Mus musculus, Sus scrofa, Vaccinia virus
Jean, F.; Basak, A.; DiMaio, J.; Seidah, N.G.; Lazure, C.
An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor
Biochem. J.
307
689-695
1995
Homo sapiens
Smeekens, S.P.; Avruch, A.S.; LaMendola, J.; Chan, S.J.; Steiner, D.F.
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans
Proc. Natl. Acad. Sci. USA
88
340-344
1991
Mus musculus
Seidah, N.G.; Chretien, M.
Pro-protein convertases of subtilisin/kexin family
Methods Enzymol.
244
175-188
1994
Homo sapiens, Mus musculus
Li, Q.L.; Jansen, E.; Brent, G.A.; Friedman, T.C.
Regulation of prohormone convertase 1 (PC1) by thyroid hormone
Am. J. Physiol. Endocrinol. Metab.
280
E160-170
2001
Homo sapiens, Rattus norvegicus
Basak, A.; Lazure, C.
Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes
Biochem. J.
373
231-239
2003
Mus musculus
Jutras, I.; Seidah, N.G.; Reudelhuber, T.L.; Brechler, V.
Two activation states of the prohormone convertase PC1 in the secretory pathway
J. Biol. Chem.
272
15184-15188
1997
Mus musculus
Boudreault, A.; Gauthier, D.; Lazure, C.
Proprotein convertase PC1/3-related peptides are potent slow tight-binding inhibitors of murine PC1/3 and Hfurin
J. Biol. Chem.
273
31574-31580
1998
BRENDA: Mus musculus
Textmining: Homo sapiens
Viale, A.; Ortola, C.; Hervieu, G.; Furuta, M.; Barbero, P.; Steiner, D.F.; Seidah, N.G.; Nahon, J.L.
Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals
J. Biol. Chem.
274
6536-6545
1999
Mus musculus, Rattus norvegicus, Rattus norvegicus Wistar
Jutras, I.; Seidah, N.G.; Reudelhuber, T.L.
A predicted alpha-helix mediates targeting of the proprotein convertase PC1 to the regulated secretory pathway
J. Biol. Chem.
275
40337-40343
2000
Mus musculus, Rattus norvegicus
Basak, A.; Koch, P.; Dupelle, M.; Fricker, L.D.; Devi, L.A.; Chretien, M.; Seidah, N.G.
Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1
J. Biol. Chem.
276
32720-32728
2001
Mus musculus
Li, Q.L.; Jansen, E.; Friedman, T.C.
Regulation of prohormone convertase 1 (PC1) by gp130-related cytokines
Mol. Cell. Endocrinol.
158
143-152
1999
Mus musculus, Rattus norvegicus
Muller, L.; Lindberg, I.
The cell biology of the prohormone convertases PC1 and PC2
Prog. Nucleic Acid Res. Mol. Biol.
63
69-108
1999
Drosophila sp. (in: flies), Mus musculus, no activity in Caenorhabditis elegans, Rattus norvegicus, no activity in Lymnaea stagnalis
Boudreault, A.; Gauthier, D.; Rondeau, N.; Savaria, D.; Seidah, N.G.; Chretien, M.; Lazure, C.
Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells
Protein Expr. Purif.
14
353-366
1998
BRENDA: Mus musculus
Textmining: Autographa californica nucleopolyhedrovirus, Spodoptera frugiperda, Transformation
Bonic, A.; Mackin, R.B.
Expression, purification, and PC1-mediated processing of human proglucagon, glicentin, and major proglucagon fragment
Protein Expr. Purif.
28
15-24
2003
Homo sapiens
Otsuji, T.; Okuda-Ashitaka, E.; Kojima, S.; Akiyama, H.; Ito, S.; Ohmiya, Y.
Monitoring for dynamic biological processing by intramolecular bioluminescence resonance energy transfer system using secreted luciferase
Anal. Biochem.
329
230-237
2004
insertion sequences
Stettler, H.; Suri, G.; Spiess, M.
Proprotein convertase PC3 is not a transmembrane protein
Biochemistry
44
5339-5345
2005
Homo sapiens
Tzimas, G.N.; Chevet, E.; Jenna, S.; Nguyen, D.T.; Khatib, A.M.; Marcus, V.; Zhang, Y.; Chretien, M.; Seidah, N.; Metrakos, P.
Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases
BMC Cancer
5
149
2005
Homo sapiens
Marzban, L.; Trigo-Gonzalez, G.; Zhu, X.; Rhodes, C.J.; Halban, P.A.; Steiner, D.F.; Verchere, C.B.
Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide
Diabetes
53
141-148
2004
Mus musculus
Posner, S.F.; Vaslet, C.A.; Jurofcik, M.; Lee, A.; Seidah, N.G.; Nillni, E.A.
Stepwise posttranslational processing of pro-growth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1
Endocrine
23
199-213
2004
Mus musculus
Dey, A.; Norrbom, C.; Zhu, X.; Stein, J.; Zhang, C.; Ueda, K.; Steiner, D.F.
Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone
Endocrinology
145
1961-1971
2004
Mus musculus
Dey, A.; Lipkind, G.M.; Rouille, Y.; Norrbom, C.; Stein, J.; Zhang, C.; Carroll, R.; Steiner, D.F.
Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon
Endocrinology
146
713-727
2005
Mus musculus
Salvas, A.; Benjannet, S.; Reudelhuber, T.L.; Chretien, M.; Seidah, N.G.
Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi
FEBS Lett.
579
5621-5625
2005
Mus musculus
Mulcahy, L.R.; Vaslet, C.A.; Nillni, E.A.
Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides
J. Biol. Chem.
280
39818-39826
2005
BRENDA: Rattus norvegicus
Textmining: Rattus
Ugleholdt, R.; Poulsen, M.L.; Holst, P.J.; Irminger, J.C.; Orskov, C.; Pedersen, J.; Rosenkilde, M.M.; Zhu, X.; Steiner, D.F.; Holst, J.J.
Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor
J. Biol. Chem.
281
11050-11057
2006
Mus musculus
Rabah, N.; Gauthier, D.; Wilkes, B.C.; Gauthier, D.J.; Lazure, C.
Single amino acid substitution in the PC1/3 propeptide can induce significant modifications of its inhibitory profile toward its cognate enzyme
J. Biol. Chem.
281
7556-7567
2006
Mus musculus (P63239)
Sanchez, V.C.; Goldstein, J.; Stuart, R.C.; Hovanesian, V.; Huo, L.; Munzberg, H.; Friedman, T.C.; Bjorbaek, C.; Nillni, E.A.
Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone
J. Clin. Invest.
114
357-369
2004
Rattus norvegicus
Lee, S.N.; Prodhomme, E.; Lindberg, I.
Prohormone convertase 1 (PC1) processing and sorting: effect of PC1 propeptide and proSAAS
J. Endocrinol.
182
353-364
2004
Mus musculus
Henrich, S.; Lindberg, I.; Bode, W.; Than, M.E.
Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity
J. Mol. Biol.
345
211-227
2004
Homo sapiens
Shen, X.; Li, Q.L.; Brent, G.A.; Friedman, T.C.
Thyroid hormone regulation of prohormone convertase 1 (PC1): regional expression in rat brain and in vitro characterization of negative thyroid hormone response elements
J. Mol. Endocrinol.
33
21-33
2004
Rattus norvegicus
Tagen, M.B.; Beinfeld, M.C.
Recombinant prohormone convertase 1 and 2 cleave purified pro cholecystokinin (CCK) and a synthetic peptide containing CCK 8 Gly Arg Arg and the carboxyl-terminal flanking peptide
Peptides
26
2530-2535
2005
Mus musculus
Rabah, N.; Gauthier, D.J.; Gauthier, D.; Lazure, C.
Improved PC1/3 production through recombinant expression in insect cells and larvae
Protein Expr. Purif.
37
377-384
2004
BRENDA: Mus musculus
Textmining: Brassica oleracea var. capitata
Rabah, N.; Gauthier, D.; Dikeakos, J.D.; Reudelhuber, T.L.; Lazure, C.
The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro
FEBS J.
274
3482-3491
2007
BRENDA: Mus musculus
Textmining: Homo sapiens
Billova, S.; Galanopoulou, A.S.; Seidah, N.G.; Qiu, X.; Kumar, U.
Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain
Neuroscience
147
403-418
2007
Rattus norvegicus
Espinosa, V.P.; Ferrini, M.; Shen, X.; Lutfy, K.; Nillni, E.A.; Friedman, T.C.
Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism
Am. J. Physiol. Endocrinol. Metab.
292
E175-E186
2007
Rattus norvegicus
Wideman, R.D.; Covey, S.D.; Webb, G.C.; Drucker, D.J.; Kieffer, T.J.
A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice
Diabetes
56
2744-2752
2007
Mus musculus
Lloyd, D.J.; Bohan, S.; Gekakis, N.
Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice
Hum. Mol. Genet.
15
1884-1893
2006
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Farooqi, I.S.; Volders, K.; Stanhope, R.; Heuschkel, R.; White, A.; Lank, E.; Keogh, J.; ORahilly, S.; Creemers, J.W.
Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3
J. Clin. Endocrinol. Metab.
92
3369-3373
2007
Homo sapiens
Lou, H.; Smith, A.M.; Coates, L.C.; Cawley, N.X.; Loh, Y.P.; Birch, N.P.
The transmembrane domain of the prohormone convertase PC3: a key motif for targeting to the regulated secretory pathway
Mol. Cell. Endocrinol.
267
17-25
2007
Mus musculus, Rattus norvegicus
Marandi, M.; Mowla, S.J.; Tavallaei, M.; Yaghoobi, M.M.; Jafarnejad, S.M.
Proprotein convertases 1 and 2 (PC1 and PC2) are expressed in neurally differentiated rat bone marrow stromal stem cells (BMSCs)
Neurosci. Lett.
420
198-203
2007
BRENDA: Rattus norvegicus
Textmining: Rattus
Rehfeld, J.F.; Zhu, X.; Norrbom, C.; Bundgaard, J.R.; Johnsen, A.H.; Nielsen, J.E.; Vikesaa, J.; Stein, J.; Dey, A.; Steiner, D.F.; Friis-Hansen, L.
Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17
Biochem. J.
415
35-43
2008
Mus musculus
Lankat-Buttgereit, B.; Mueller, S.; Schmidt, H.; Parhofer, K.G.; Gress, T.M.; Goeke, R.
Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line
Biol. Cell
100
703-715
2008
Homo sapiens
Garruti, G.; Cotecchia, S.; Giampetruzzi, F.; Giorgino, F.; Giorgino, R.
Neuroendocrine deregulation of food intake, adipose tissue and the gastrointestinal system in obesity and metabolic syndrome
J. Gastrointestin. Liver Dis.
17
193-198
2008
Homo sapiens
Fox, D.L.; Good, D.J.
Nescient helix-loop-helix 2 interacts with signal transducer and activator of transcription 3 to regulate transcription of prohormone convertase 1/3
Mol. Endocrinol.
22
1438-1448
2008
Mus musculus
Espinosa, V.P.; Liu, Y.; Ferrini, M.; Anghel, A.; Nie, Y.; Tripathi, P.V.; Porche, R.; Jansen, E.; Stuart, R.C.; Nillni, E.A.; Lutfy, K.; Friedman, T.C.
Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction
Neuroscience
156
788-799
2008
Homo sapiens, Rattus norvegicus
Gagnon, J.; Mayne, J.; Mbikay, M.; Woulfe, J.; Chretien, M.
Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine
Regul. Pept.
152
54-60
2009
Mus musculus
Zhou, J.; Cai, Z.H.
Molecular cloning and characterization of prohormone convertase 1 gene in abalone (Haliotis diversicolor supertexta)
Comp. Biochem. Physiol. B
155
331-339
2010
Haliotis diversicolor supertexta
Sun, J.; Zhang, C.; Fang, X.; Lei, C.; Lan, X.; Chen, H.
Novel single nucleotide polymorphisms of the caprine PC1 gene and association with growth traits
Biochem. Genet.
48
779-788
2010
Capra hircus (D8V3M2)
Ozawa, A.; Peinado, J.R.; Lindberg, I.
Modulation of prohormone convertase 1/3 properties using site-directed mutagenesis
Endocrinology
151
4437-4445
2010
Mus musculus
Kilimnik, G.; Kim, A.; Steiner, D.; Friedman, T.; Hara, M.
Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic alpha-cells in mouse models of beta-cell regeneration
Islets
2
149-155
2010
Mus musculus
Zhan, S.; Zhou, A.; Lan, J.; Yang, T.
Proprotein convertase 1 mRNA and protein expression in ischemic rat cortex after reperfusion
Neural Regen. Res.
6
295-299
2011
Rattus norvegicus
-
Hiramoto, K.; Yamate, Y.; Kobayashi, H.; Ishii, M.; Sato, E.F.; Inoue, M.
Ultraviolet B irradiation of the mouse eye induces pigmentation of the skin more strongly than does stress loading, by increasing the levels of prohormone convertase 2 and alpha-melanocyte-stimulating hormone
Clin. Exp. Dermatol.
38
71-76
2013
Mus musculus (P63239)
Ozawa, S.; Katsuta, H.; Suzuki, K.; Takahashi, K.; Tanaka, T.; Sumitani, Y.; Nishida, S.; Yoshimoto, K.; Ishida, H.
Estimated proinsulin processing activity of prohormone convertase (PC) 1/3 rather than PC2 is decreased in pancreatic beta-cells of type 2 diabetic patients
Endocr. J.
61
607-614
2014
Homo sapiens (P29120)
Blanco, E.H.; Peinado, J.R.; Martin, M.G.; Lindberg, I.
Biochemical and cell biological properties of the human prohormone convertase 1/3 Ser357Gly mutation: a PC1/3 hypermorph
Endocrinology
155
3434-3447
2014
Homo sapiens (P29120)
Gagnon, H.; Refaie, S.; Gagnon, S.; Desjardins, R.; Salzet, M.; Day, R.
Proprotein convertase 1/3 (PC1/3) in the rat alveolar macrophage cell line NR8383: localization, trafficking and effects on cytokine secretion
PLoS ONE
8
e61557
2013
Rattus norvegicus
Wilschanski, M.; Abbasi, M.; Blanco, E.; Lindberg, I.; Yourshaw, M.; Zangen, D.; Berger, I.; Shteyer, E.; Pappo, O.; Bar-Oz, B.; Martin, M.G.; Elpeleg, O.
A novel familial mutation in the PCSK1 gene that alters the oxyanion hole residue of proprotein convertase 1/3 and impairs its enzymatic activity
PLoS ONE
9
e108878
2014
Homo sapiens (P29120)
Elferich, J.; Williamson, D.M.; David, L.L.; Shinde, U.
Determination of histidine pKa values in the propeptides of furin and proprotein convertase 1/3 using histidine hydrogen-deuterium exchange mass spectrometry
Anal. Chem.
87
7909-7917
2015
Homo sapiens (P29120)
Righi, A.; Faustini-Fustini, M.; Morandi, L.; Monti, V.; Asioli, S.; Mazzatenta, D.; Bacci, A.; Foschini, M.P.
The changing faces of corticotroph cell adenomas the role of prohormone convertase 1/3
Endocrine
56
286-297
2017
Homo sapiens (P29120)
Li, J.; Mao, Z.; Huang, J.; Xia, J.
PICK1 is essential for insulin production and the maintenance of glucose homeostasis
Mol. Biol. Cell
29
587-596
2018
Mus musculus
Duhamel, M.; Rodet, F.; Murgoci, A.N.; Desjardins, R.; Gagnon, H.; Wisztorski, M.; Fournier, I.; Day, R.; Salzet, M.
The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways
Sci. Rep.
6
19360
2016
BRENDA: Mus musculus
Textmining: Mus sp., Rattus
Nakayama, K; Kim, WS; Torii, S; Hosaka, M; Nakagawa, T; Ikemizu, J; Baba, T; Murakami, K
Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression.
J Biol Chem
267
5897-900
1992
Saccharomyces cerevisiae, Mus musculus
Feng, Y; Reznik, SE; Fricker, LD
ProSAAS and prohormone convertase 1 are broadly expressed during mouse development.
Brain Res Gene Expr Patterns
1
135-40
2002
Mus musculus
Creemers, JW; Choquet, H; Stijnen, P; Vatin, V; Pigeyre, M; Beckers, S; Meulemans, S; Than, ME; Yengo, L; Tauber, M; Balkau, B; Elliott, P; Jarvelin, MR; Van Hul, W; Van Gaal, L; Horber, F; Pattou, F; Froguel, P; Meyre, D
Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity.
Diabetes
61
383-90
2012
Homo sapiens, Mus musculus
Wang, L; Sui, L; Panigrahi, SK; Meece, K; Xin, Y; Kim, J; Gromada, J; Doege, CA; Wardlaw, SL; Egli, D; Leibel, RL
PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons.
Stem Cell Reports
8
264-277
2017
Homo sapiens, Mus sp.
Shakya, M; Gahlot, S; White, A; Verchere, CB; Low, MJ; Lindberg, I
Mice lacking PC1/3 expression in POMC-expressing cells do not develop obesity.
Endocrinology
2021
Mus sp., Mus musculus
Creemers, JW; Roebroek, AJ; Van de Ven, WJ
Expression in human lung tumor cells of the proprotein processing enzyme PC1/PC3. Cloning and primary sequence of a 5 kb cDNA.
FEBS Lett
300
82-8
1992
Homo sapiens
Konoshita, T; Gasc, JM; Villard, E; Takeda, R; Seidah, NG; Corvol, P; Pinet, F
Expression of PC2 and PC1/PC3 in human pheochromocytomas.
Mol Cell Endocrinol
99
307-14
1994
Homo sapiens
Ohagi, S; Sakaguchi, H; Sanke, T; Tatsuta, H; Hanabusa, T; Nanjo, K
Human prohormone convertase 3 gene: exon-intron organization and molecular scanning for mutations in Japanese subjects with NIDDM.
Diabetes
45
897-901
1996
Homo sapiens
Tanaka, S; Kurabuchi, S; Mochida, H; Kato, T; Takahashi, S; Watanabe, T; Nakayama, K
Immunocytochemical localization of prohormone convertases PC1/PC3 and PC2 in rat pancreatic islets.
Arch Histol Cytol
59
261-71
1996
Rattus, Oryctolagus cuniculus
Hörsch, D; Day, R; Seidah, NG; Weihe, E; Schäfer, MK
Immunohistochemical localization of the pro-peptide processing enzymes PC1/PC3 and PC2 in the human anal canal.
Peptides
18
755-60
1997
Homo sapiens
Szpirer, C; Tissir, F; Rivière, M; Van Vooren, P; Kela, J; Lallemand, F; Gabant, P; Hoebee, B; Klinga-Levan, K; Levan, G; Szpirer, J
Rat Chromosome 2: assignment of the genes encoding cyclin B1, interleukin 6 signal transducer, and proprotein convertase 1 to the Mcs1-containing region and identification of new microsatellite markers.
Mamm Genome
10
30-4
1999
Rattus
Quan, X; Laes, JF; Ravoet, M; Van Vooren, P; Szpirer, J; Szpirer, C
Localization of new, microdissection- generated, anonymous markers and of the genes Pcsk1, Dhfr, Ndub13, and Ccnb1 to rat chromosome region 2q1.
Cytogenet Cell Genet
88
119-23
2000
Rattus
Jackson, RS; Creemers, JW; Farooqi, IS; Raffin-Sanson, ML; Varro, A; Dockray, GJ; Holst, JJ; Brubaker, PL; Corvol, P; Polonsky, KS; Ostrega, D; Becker, KL; Bertagna, X; Hutton, JC; White, A; Dattani, MT; Hussain, K; Middleton, SJ; Nicole, TM; Milla, PJ; Lindley, KJ; O'Rahilly, S
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.
J Clin Invest
112
1550-60
2003
Homo sapiens, Mus sp.
St Germain, C; Croissandeau, G; Mayne, J; Baltz, JM; Chrétien, M; Mbikay, M
Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.
Mol Reprod Dev
72
483-93
2005
Mus musculus, Homo sapiens
Mbikay, M; Croissandeau, G; Sirois, F; Anini, Y; Mayne, J; Seidah, NG; Chrétien, M
A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.
Dev Biol
306
584-98
2007
Mus musculus, insertion sequences, Mus sp.
Morash, MG; MacDonald, AB; Croll, RP; Anini, Y
Molecular cloning, ontogeny and tissue distribution of zebrafish (Danio rerio) prohormone convertases: pcsk1 and pcsk2.
Gen Comp Endocrinol
162
179-87
2009
Danio rerio, Chondrichthyes
Blanchard, A; Iwasiow, B; Yarmill, A; Fresnosa, A; Silha, J; Myal, Y; Murphy, LC; Chrétien, M; Seidah, N; Shiu, RP
Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic mice.
Can J Physiol Pharmacol
87
831-8
2009
Homo sapiens, mouse mammary tumor virus, Mus musculus, Mus sp.
Yourshaw, M; Solorzano-Vargas, RS; Pickett, LA; Lindberg, I; Wang, J; Cortina, G; Pawlikowska-Haddal, A; Baron, H; Venick, RS; Nelson, SF; Martín, MG
Exome sequencing finds a novel PCSK1 mutation in a child with generalized malabsorptive diarrhea and diabetes insipidus.
J Pediatr Gastroenterol Nutr
57
759-67
2013
Homo sapiens
Philippe, J; Stijnen, P; Meyre, D; De Graeve, F; Thuillier, D; Delplanque, J; Gyapay, G; Sand, O; Creemers, JW; Froguel, P; Bonnefond, A
A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity.
Int J Obes (Lond)
2014
Homo sapiens
Kulanuwat, S; Phonrat, B; Tungtrongchitr, A; Limwongse, C; Chongviriyaphan, N; Tungtrongchitr, R; Santiprabhob, J
Effects of PCSK1 genetic variants on obesity among Thai children and their family members: in relation to health risk, and biochemical and anthropometric parameters.
Southeast Asian J Trop Med Public Health
45
214-25
2014
Homo sapiens, Thais
Sun, J; Shan, L; Zhang, C; Chen, H
Haplotype combination of the bovine PCSK1 gene sequence variants and association with growth traits in Jiaxian cattle.
J Genet
93
e123-9
2014
Bos taurus
Kulanuwat, S; Santiprabhob, J; Phonrat, B; Limwongse, C; Tungtrongchitr, A; Chongviriyaphan, N; Tungtrongchitr, R
Association between rs155971 in the PCSK1 gene and the lipid profile of obese Thai children: a family-based study.
Genet Mol Res
14
9136-44
2015
Homo sapiens
Stijnen, P; Brouwers, B; Dirkx, E; Ramos-Molina, B; Van Lommel, L; Schuit, F; Thorrez, L; Declercq, J; Creemers, JW
Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity.
Int J Obes (Lond)
2016
Homo sapiens, Mus musculus, Mus sp.
Stijnen, P; Ramos-Molina, B; O'Rahilly, S; Creemers, JW
PCSK1 Mutations and Human Endocrinopathies: From Obesity to Gastrointestinal Disorders.
Endocr Rev
37
347-71
2016
Homo sapiens
Ramos-Molina, B; Martin, MG; Lindberg, I
PCSK1 Variants and Human Obesity.
Prog Mol Biol Transl Sci
140
47-74
2016
Homo sapiens
Nordang, GB; Busk, ØL; Tveten, K; Hanevik, HI; Fell, AK; Hjelmesæth, J; Holla, ØL; Hertel, JK
Next-generation sequencing of the monogenic obesity genes LEP, LEPR, MC4R, PCSK1 and POMC in a Norwegian cohort of patients with morbid obesity and normal weight controls.
Mol Genet Metab
2017
Homo sapiens
Muhsin, NIA; Bentley, L; Bai, Y; Goldsworthy, M; Cox, RD
A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes.
Mamm Genome
31
17-29
2020
Mus musculus, Homo sapiens
Cho, YK; Lee, JM; Song, G; Choi, HS; Cho, EH; Kim, SW
The Ominous Trio of PCSK1, CHD7, and PAX4: Normosmic Hypogonadotropic Hypogonadism with Maturity-Onset Diabetes in a Young Man.
Clin Endocrinol (Oxf)
2020
Homo sapiens
Saikia, M; Holter, MM; Donahue, LR; Lee, IS; Zheng, QC; Wise, JL; Todero, JE; Phuong, DJ; Garibay, D; Coch, R; Sloop, KW; Garcia-Ocana, A; Danko, CG; Cummings, BP
GLP-1 receptor signaling increases PCSK1 and ? cell features in human ? cells.
JCI Insight
6
2021
Homo sapiens
Qian, Y; Wu, B; Liu, R; Lu, Y; Zhang, P; Shao, C; Huang, Y; Wang, H
Case Report: Complete Maternal Uniparental Isodisomy of Chromosome 5 (iUPD(5)mat) With PCSK1 Nonsense Variant in an Infant With Recurrent Diarrhea.
Front Genet
12
668326
2021
Homo sapiens
Aerts, L; Terry, NA; Sainath, NN; Torres, C; Martín, MG; Ramos-Molina, B; Creemers, JW
Novel Homozygous Inactivating Mutation in the PCSK1 Gene in an Infant with Congenital Malabsorptive Diarrhea.
Genes (Basel)
12
2021
Homo sapiens
Obaroakpo, JU; Liu, L; Zhang, S; Lu, J; Liu, L; Pang, X; Lv, J
In vitro modulation of glucagon-like peptide release by DPP-IV inhibitory polyphenol-polysaccharide conjugates of sprouted quinoa yoghurt.
Food Chem
324
126857
2020
Chenopodium quinoa
LaMendola, J; Martin, SK; Steiner, DF
Expression of PC3, carboxypeptidase E and enkephalin in human monocyte-derived macrophages as a tool for genetic studies.
FEBS Lett
404
19-22
1997
Homo sapiens
Reudelhuber, TL; Ramla, D; Chiu, L; Mercure, C; Seidah, NG
Proteolytic processing of human prorenin in renal and non-renal tissues.
Kidney Int
46
1522-4
1994
Homo sapiens, Mus musculus
Ahlqvist, E; Turrini, F; Lang, ST; Taneera, J; Zhou, Y; Almgren, P; Hansson, O; Isomaa, B; Tuomi, T; Eriksson, K; Eriksson, JG; Lyssenko, V; Groop, L
A common variant upstream of the PAX6 gene influences islet function in man.
Diabetologia
55
94-104
2012
Homo sapiens
Fontanesi, L; Bertolini, F; Scotti, E; Trevisi, P; Buttazzoni, L; Dall'olio, S; Davoli, R; Bosi, P; Russo, V
Polymorphisms in an obesity-related gene (PCSK1) are associated with fat deposition and production traits in Italian heavy pigs.
Animal
6
1913-24
2012
Suidae, Homo sapiens, Sus scrofa, Metazoa, Pieris brassicae
Nagle, GT; van Heumen, WR; Knock, SL; Garcia, AT; McCullough, DA; Kurosky, A
Occurrence of a furin-like prohormone processing enzyme in Aplysia neuroendocrine bag cells.
Comp Biochem Physiol B
105
345-8
1993
Saccharomyces cerevisiae, Aplysia californica, Homo sapiens, Mus musculus
Oliva, AA; Chan, SJ; Steiner, DF
Evolution of the prohormone convertases: identification of a homologue of PC6 in the protochordate amphioxus.
Biochim Biophys Acta
1477
338-48
2000
Branchiostoma lanceolatum, vertebrata
Zakaria, A; Berthault, C; Cosson, B; Jung, V; Guerrera, IC; Rachdi, L; Scharfmann, R
Glucose treatment of human pancreatic ?-cells enhances translation of mRNAs involved in energetics and insulin secretion.
J Biol Chem
297
100839
2021
Homo sapiens
Sebaai, N; Lesage, J; Breton, C; Vieau, D; Deloof, S
Perinatal food deprivation induces marked alterations of the hypothalamo-pituitary-adrenal axis in 8-month-old male rats both under basal conditions and after a dehydration period.
Neuroendocrinology
79
163-73
2004
Rattus, Metazoa, Hippocampus
Yu, Y; Wang, X; Liu, C; Yao, D; Hu, M; Li, J; Hu, N; Liu, L; Liu, X
Combined contributions of over-secreted glucagon-like peptide 1 and suppressed insulin secretion to hyperglycemia induced by gatifloxacin in rats.
Toxicol Appl Pharmacol
266
375-84
2013
Rattus, Homo sapiens
Dušátková, L; Zamrazilová, H; Sedlá?ková, B; V?elák, J; Hlavatý, P; Aldhoon Hainerová, I; Korenková, V; Bradnová, O; Bendlová, B; Kunešová, M; Hainer, V
Association of obesity susceptibility gene variants with metabolic syndrome and related traits in 1,443 czech adolescents.
Folia Biol (Praha)
59
123-33
2013
Homo sapiens
Wang, Y; Wang, A; Donovan, SM; Teran-Garcia, M
Individual Genetic Variations Related to Satiety and Appetite Control Increase Risk of Obesity in Preschool-Age Children in the STRONG Kids Program.
Hum Hered
75
152-159
2013
Homo sapiens
Bauer, Y; Tedrow, J; de Bernard, S; Birker-Robaczewska, M; Gibson, KF; Juan Guardela, B; Hess, P; Klenk, A; Lindell, KO; Poirey, S; Renault, B; Rey, M; Weber, E; Nayler, O; Kaminski, N
A Novel Genomic Signature with Translational Significance for Human Idiopathic Pulmonary Fibrosis.
Am J Respir Cell Mol Biol
2014
Homo sapiens
Dušátková, L; Zamrazilová, H; Aldhoon Hainerová, I; Atkinson, RL; Sedlá?ková, B; Lee, ZP; V?elák, J; Bendlová, B; Kunešová, M; Hainer, V
Association of adenovirus 36 infection with obesity-related gene variants in adolescents.
Physiol Res
64 Suppl 2
S197-202
2015
Homo sapiens, Human adenovirus 36
Min, SY; Kady, J; Nam, M; Rojas-Rodriguez, R; Berkenwald, A; Kim, JH; Noh, HL; Kim, JK; Cooper, MP; Fitzgibbons, T; Brehm, MA; Corvera, S
Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice.
Nat Med
22
312-8
2016
Electron, Homo sapiens, Mus sp.
Raboin, MJ; Letaw, J; Mitchell, AD; Toffey, D; McKelvey, J; Roberts, CT; Curran, JE; Vinson, A
Genetic Architecture of Human Obesity Traits in the Rhesus Macaque.
Obesity (Silver Spring)
27
479-488
2019
Homo sapiens, Macaca, Metazoa
Ak?nc?, A; Turkkahraman, D; Tekedereli, I; Özer, L; Evren, B; Sahin, ?; Kalkan, T; Çürek, Y; Çamtosun, E; Do?er, E; Bideci, A; Güven, A; Eren, E; Sangün, Ö; Çay?r, A; Bilir, P; Törel Ergür, A; Ercan, O
Novel Mutations in Obesity-Related Genes in Turkish Children with Non-Syndromic Early Onset Severe Obesity: A Multicentre Study
J Clin Res Pediatr Endocrinol
2019
Homo sapiens
Cooiman, MI; Kleinendorst, L; Aarts, EO; Janssen, IMC; van Amstel, HKP; Blakemore, AI; Hazebroek, EJ; Meijers-Heijboer, HJ; van der Zwaag, B; Berends, FJ; van Haelst, MM
Genetic Obesity and Bariatric Surgery Outcome in 1014 Patients with Morbid Obesity.
Obes Surg
30
470-477
2020
Homo sapiens
Shi, XW; Lyu, AL; Wang, S; Lyu, M; Yue, J
[Heritability of obesity in children aged 30-36 months and an analysis of single nucleotide polymorphisms at four loci in Xi'an, China].
Zhongguo Dang Dai Er Ke Za Zhi
22
355-360
2020
Homo sapiens
Guan, Y; Sun, H; Chen, H; Li, P; Shan, Y; Li, X
Physicochemical characterization and the hypoglycemia effects of polysaccharide isolated from Passiflora edulis Sims peel.
Food Funct
12
4221-4230
2021
Passiflora edulis, Mus sp.
Icimoto, MY; Barros, NM; Ferreira, JC; Marcondes, MF; Andrade, D; Machado, MF; Juliano, MA; Júdice, WA; Juliano, L; Oliveira, V
Hysteretic behavior of proprotein convertase 1/3 (PC1/3).
PLoS One
6
e24545
2011
Mus musculus, Transformation
Mbikay, M; Sirois, F; Nkongolo, KK; Basak, A; Chrétien, M
Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity.
Mol Genet Metab
104
682-7
2011
Homo sapiens
Lee, SN; Lee, DH; Sohn, MH; Yoon, JH
Overexpressed PC1/3 induces an epithelial-mesenchymal transition in airway epithelium.
Eur Respir J
2013
Homo sapiens
Hsiao, TJ; Hwang, Y; Chang, HM; Lin, E
Association of the rs6235 variant in the proprotein convertase subtilisin/kexin type 1 (PCSK1) gene with obesity and related traits in a Taiwanese population.
Gene
533
32-7
2014
Homo sapiens
Prabhu, Y; Blanco, EH; Liu, M; Peinado, JR; Wheeler, MC; Gekakis, N; Arvan, P; Lindberg, I
Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function.
Endocrinology
155
2391-401
2014
Homo sapiens, Mus musculus, Mus sp.
Härter, B; Fuchs, I; Müller, T; Akbulut, UE; Cakir, M; Janecke, AR
Early Clinical Diagnosis of PC1/3 Deficiency in a Patient With a Novel Homozygous PCSK1 Splice-Site Mutation.
J Pediatr Gastroenterol Nutr
62
577-80
2016
Homo sapiens
Pépin, L; Colin, E; Tessarech, M; Rouleau, S; Bouhours-Nouet, N; Bonneau, D; Coutant, R
A New Case of PCSK1 Pathogenic Variant With Congenital Proprotein Convertase 1/3 Deficiency and Literature Review.
J Clin Endocrinol Metab
104
985-993
2019
Homo sapiens
Greenwood, M; Paterson, A; Rahman, PA; Gillard, BT; Langley, S; Iwasaki, Y; Murphy, D; Greenwood, MP
Transcription factor Creb3l1 regulates the synthesis of prohormone convertase enzyme PC1/3 in endocrine cells.
J Neuroendocrinol
32
e12851
2020
Rattus
Gendron, FP; Mongrain, S; Laprise, P; McMahon, S; Dubois, CM; Blais, M; Asselin, C; Rivard, N
The CDX2 transcription factor regulates furin expression during intestinal epithelial cell differentiation.
Am J Physiol Gastrointest Liver Physiol
290
G310-8
2006
Rattus
Burnett, LC; LeDuc, CA; Sulsona, CR; Paull, D; Rausch, R; Eddiry, S; Carli, JF; Morabito, MV; Skowronski, AA; Hubner, G; Zimmer, M; Wang, L; Day, R; Levy, B; Fennoy, I; Dubern, B; Poitou, C; Clement, K; Butler, MG; Rosenbaum, M; Salles, JP; Tauber, M; Driscoll, DJ; Egli, D; Leibel, RL
Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome.
J Clin Invest
127
293-305
2017
Mus sp.
Sawada, M; Finniss, S; Dickinson, CJ
Diminished prohormone convertase 3 expression (PC1/PC3) inhibits progastrin post-translational processing.
Regul Pept
89
19-28
2000
Homo sapiens
Creemers, JW; Pritchard, LE; Gyte, A; Le Rouzic, P; Meulemans, S; Wardlaw, SL; Zhu, X; Steiner, DF; Davies, N; Armstrong, D; Lawrence, CB; Luckman, SM; Schmitz, CA; Davies, RA; Brennand, JC; White, A
Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132: interaction between AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3.
Endocrinology
147
1621-31
2006
Mus sp., Rattus
Benzinou, M; Creemers, JW; Choquet, H; Lobbens, S; Dina, C; Durand, E; Guerardel, A; Boutin, P; Jouret, B; Heude, B; Balkau, B; Tichet, J; Marre, M; Potoczna, N; Horber, F; Le Stunff, C; Czernichow, S; Sandbaek, A; Lauritzen, T; Borch-Johnsen, K; Andersen, G; Kiess, W; Körner, A; Kovacs, P; Jacobson, P; Carlsson, LM; Walley, AJ; Jørgensen, T; Hansen, T; Pedersen, O; Meyre, D; Froguel, P
Common nonsynonymous variants in PCSK1 confer risk of obesity.
Nat Genet
40
943-5
2008
Homo sapiens
Qi, Q; Li, H; Loos, RJ; Liu, C; Hu, FB; Wu, H; Yu, Z; Lin, X
Association of PCSK1 rs6234 with obesity and related traits in a Chinese Han population.
PLoS One
5
e10590
2010
Homo sapiens
Choquet, H; Stijnen, P; Creemers, JW
Genetic and Functional Characterization of PCSK1.
Methods Mol Biol
768
247-53
2011
Homo sapiens
Li, XM; Ling, Y; Lu, DR; Lu, ZQ; Liu, Y; Chen, HY; Gao, X
The obesity-related polymorphism PCSK1 rs6235 is associated with essential hypertension in the Han Chinese population.
Hypertens Res
2012
Homo sapiens
Villalobos-Comparán, M; Villamil-Ramírez, H; Villarreal-Molina, T; Larrieta-Carrasco, E; León-Mimila, P; Romero-Hidalgo, S; Jacobo-Albavera, L; Liceaga-Fuentes, AE; Campos-Pérez, FJ; López-Contreras, BE; Tusié-Luna, T; Del Río-Navarro, BE; Aguilar-Salinas, CA; Canizales-Quinteros, S
PCSK1 rs6232 is associated with childhood and adult class III obesity in the Mexican population.
PLoS One
7
e39037
2012
Homo sapiens
Wei, X; Ma, X; Lu, R; Bai, G; Zhang, J; Deng, R; Gu, N; Feng, N; Guo, X
Genetic variants in PCSK1 gene are associated with the risk of coronary artery disease in type 2 diabetes in a Chinese Han population: a case control study.
PLoS One
9
e87168
2014
Homo sapiens
Gu, Q; Yazdanpanah, M; van Hoek, M; Hofman, A; Gao, X; de Rooij, FW; Sijbrands, EJ
Common variants in PCSK1 influence blood pressure and body mass index.
J Hum Hypertens
2014
Homo sapiens
Stijnen, P; Tuand, K; Varga, TV; Franks, PW; Aertgeerts, B; Creemers, JW
The association of common variants in PCSK1 with obesity: a HuGE review and meta-analysis.
Am J Epidemiol
180
1051-65
2014
Homo sapiens
Löffler, D; Behrendt, S; Creemers, JW; Klammt, J; Aust, G; Stanik, J; Kiess, W; Kovacs, P; Körner, A
Functional and clinical relevance of novel and known PCSK1 variants for childhood obesity and glucose metabolism.
Mol Metab
6
295-305
2017
Homo sapiens
Tang, SS; Liang, ZY; Guo, LR; Zhang, JH; Zhou, D
Proprotein convertase 1 mediated proneuropeptide proteolytic processing in ischemic neuron injury.
Bratisl Lek Listy
118
609-612
2017
Mus musculus, Transformation
Ramos-Molina, B; Molina-Vega, M; Fernández-García, JC; Creemers, JW
Hyperphagia and Obesity in Prader?Willi Syndrome: PCSK1 Deficiency and Beyond?
Genes (Basel)
9
2018
Homo sapiens
Jarvela, TS; Gahlot, S; Shakya, M; Bachor, T; White, A; Low, MJ; Lindberg, I
Reduced stability and pH-dependent activity of a common obesity-linked PCSK1 polymorphism, N221D.
Endocrinology
2019
Homo sapiens, Mus musculus
Zhou, J; Yang, L; Yu, J; Zhang, K; Xu, Z; Cao, Z; Luan, P; Li, H; Zhang, H
Association of PCSK1 gene polymorphisms with abdominal fat content in broilers.
Anim Sci J
91
e13371
0
Gallus gallus
Chou, CL; Chen, TJ; Lin, CY; Lee, SW; Wang, SC; Chu, SS; Yang, CC
PCSK1 Overexpression in Rectal Cancer Correlates with Poor Response to Preoperative Chemoradiotherapy and Prognosis.
Onco Targets Ther
13
3141-3150
2020
Homo sapiens
Lin, E; Pei, D; Huang, YJ; Hsieh, CH; Wu, LS
Gene-gene interactions among genetic variants from obesity candidate genes for nonobese and obese populations in type 2 diabetes.
Genet Test Mol Biomarkers
13
485-93
2009
Homo sapiens
Alarcon, C; Verchere, CB; Rhodes, CJ
Translational Control of Glucose-Induced Islet Amyloid Polypeptide Production in Pancreatic Islets.
Endocrinology
2012
Rattus
Choi, S; Korstanje, R
Proprotein convertases in high-density lipoprotein metabolism.
Biomark Res
1
27
2013
Mus musculus
Ayers, KL; Glicksberg, BS; Garfield, AS; Longerich, S; White, JA; Yang, P; Du, L; Chittenden, TW; Gulcher, JR; Roy, S; Fiedorek, F; Gottesdiener, K; Cohen, S; North, KE; Schadt, EE; Li, SD; Chen, R; Van der Ploeg, LHT
Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment.
J Clin Endocrinol Metab
103
2601-2612
2018
Homo sapiens
Dong, X; Chiu, H; Park, YJ; Zou, W; Zou, Y; Özkan, E; Chang, C; Shen, K
Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions.
Elife
5
2016
Caenorhabditis elegans
Kaur, H; Muhlhausler, BS; Sim, PS; Page, A; Li, H; Nunez-Salces, M; Clarke, GS; Huang, L; Wilson, RL; Veldhuis, JD; Chen, C; Roberts, CT; Gatford, KL
Pregnancy, but not dietary octanoic acid supplementation, stimulates the ghrelin-pituitary growth.
J Endocrinol
2020
Mus sp.
Papers to appear in forthcoming issues
Protein Expr Purif
14
IV
1998
Mus musculus, Alain
Bell, ME; McDonald, TJ; Myers, DA
Proopiomelanocortin processing in the anterior pituitary of the ovine fetus after lesion of the hypothalamic paraventricular nucleus.
Endocrinology
146
2665-73
2005
Ovis aries
Nath, AK; Krauthammer, M; Li, P; Davidov, E; Butler, LC; Copel, J; Katajamaa, M; Oresic, M; Buhimschi, I; Buhimschi, C; Snyder, M; Madri, JA
Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects.
PLoS ONE
4
e4221
2009
Homo sapiens
Corpeleijn, E; Petersen, L; Holst, C; Saris, WH; Astrup, A; Langin, D; Macdonald, I; Martinez, JA; Oppert, JM; Polak, J; Pedersen, O; Froguel, P; Arner, P; Sørensen, TI; Blaak, EE
Obesity-related Polymorphisms and Their Associations With the Ability to Regulate Fat Oxidation in Obese Europeans: The NUGENOB Study.
Obesity (Silver Spring)
2009
Candida dubliniensis
Yu, Y; Liu, L; Wang, X; Liu, X; Liu, X; Xie, L; Wang, G
Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies.
Biochem Pharmacol
79
1000-6
2010
Rattus
Malouf, GG; Job, S; Paradis, V; Fabre, M; Brugières, L; Saintigny, P; Vescovo, L; Belghiti, J; Branchereau, S; Faivre, S; de Reyniès, A; Raymond, E
Transcriptional profiling of pure fibrolamellar hepatocellular carcinoma reveals an endocrine signature.
Hepatology
2014
Homo sapiens
Ramalingam, S; Eisenberg, A; Foo, WC; Freedman, J; Armstrong, AJ; Moss, LG; Harrison, MR
Treatment-related neuroendocrine prostate cancer resulting in Cushing's syndrome.
Int J Urol
23
1038-1041
2016
Homo sapiens
Enya, M; Horikawa, Y; Iizuka, K; Takeda, J
Association of genetic variants of the incretin-related genes with quantitative traits and occurrence of type 2 diabetes in Japanese.
Mol Genet Metab Rep
1
350-361
2014
Homo sapiens
Skarbaliene, J; Rigbolt, KT; Fosgerau, K; Billestrup, N
In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes.
Eur J Pharmacol
2017
Rattus
Polex-Wolf, J; Lam, BY; Larder, R; Tadross, J; Rimmington, D; Bosch, F; Cenzano, VJ; Ayuso, E; Ma, MK; Rainbow, K; Coll, AP; O'Rahilly, S; Yeo, GS
Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.
J Clin Invest
128
960-969
2018
Mus sp.
Caralli, M; Roman, C; Coste, ME; Roquelaure, B; Buffat, C; Bourgeois, P; Badens, C; Fabre, A
Genetic Enteropathies Linked to Epithelial Structural Abnormalities and Enteroendocrine Deficiency: A Systematic Review.
J Pediatr Gastroenterol Nutr
72
826-832
2021
Homo sapiens
Courbage, S; Poitou, C; Le Beyec-Le Bihan, J; Karsenty, A; Lemale, J; Pelloux, V; Lacorte, JM; Carel, JC; Lecomte, N; Storey, C; De Filippo, G; Coupaye, M; Oppert, JM; Tounian, P; Clément, K; Dubern, B
Implication of heterozygous variants in genes of the leptin-melanocortin pathway in severe obesity.
J Clin Endocrinol Metab
2021
Homo sapiens
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