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Information on EC 3.4.21.92 - Endopeptidase Clp and Organism(s) Mus musculus and UniProt Accession O88696

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.92 Endopeptidase Clp
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This record set is specific for:
Mus musculus
UNIPROT: O88696 not found.
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The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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Hydrolysis of proteins to small peptides in the presence of ATP and Mg2+. alpha-Casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolysed (such as succinyl-Leu-Tyr-/-NHMec, and Leu-Tyr-Leu-/-Tyr-Trp, in which cleavage of the -Tyr-/-Leu- and -Tyr-/-Trp bonds also occurs)
Synonyms
clp protease, clpap, clpxp protease, clpc1, clpp1, caseinolytic protease, clpp protease, clpp2, clpp1p2, atp-dependent clp protease, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Clp protease
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ClpP Protease
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ATP-dependent Clp protease
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-
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Caseinolytic protease
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-
-
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Clp protease
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-
-
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ClpP
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-
-
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endopeptidase Clp
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-
-
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endopeptidase Ti
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-
-
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Heat shock protein F21.5
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-
-
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Protease Ti
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-
-
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stress protein G7
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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-
-
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CAS REGISTRY NUMBER
COMMENTARY hide
110910-59-3
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131017-00-0
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131017-01-1
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
casein-fluorescein isothiocyanate + H2O
?
show the reaction diagram
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-
-
?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ATP
stimulates proteolytic activity of ClpP in heart mitochondria of muscle creatine kinase mutants
additional information
frataxin deficiency causes significant upregulation of both mitochondrial Lon and ClpP proteases in the cardiac mouse model for Friedreich ataxia. ClpP protein level is progressively enhanced, with ca. 3fold, 3.5fold and 4.5fold increases at 5, 7 and 10 weeks of age in muscle creatine kinase mutants, respectively, despite no change in mRNA levels
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CLPP_MOUSE
272
0
29800
Swiss-Prot
Mitochondrion (Reliability: 3)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
Clp sequenced, nuclear encoded gene
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
correlative effect of Lon and ClpP upregulation on loss of mitochondrial Fe-S proteins during the progression of Friedreich ataxia suggesting that Fe-S proteins are potential targets of Lon and ClpP proteases in Friedreich ataxia
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Porankiewicz, J.; Wang, J.; Clarke, A.K.
New insights into the ATP-dependent Clp protease: Escherichia coli and beyond
Mol. Microbiol.
32
449-458
1999
Aquifex aeolicus (O67357), Arabidopsis thaliana (P56772), Arabidopsis thaliana (Q787X4), Bacillus subtilis (P80244), Bordetella pertussis, Borreliella burgdorferi (O51698), Caenorhabditis elegans (Q27539), Caulobacter vibrioides (B8GX16), Chlamydia trachomatis (P38002), Chlamydomonas moewusii (P42379), Chlamydomonas reinhardtii (P42380), Chlorella vulgaris (P56317), Chlorobaculum tepidum, Clostridium acetobutylicum, Cyanophora paradoxa (Q36863), Deinococcus radiodurans, Enterococcus faecalis, Epifagus virginiana (P30063), Escherichia coli, Fritillaria agrestis (O49081), Haemophilus influenzae (P43867), Helicobacter pylori, Homo sapiens (Q16740), Lactococcus lactis (Q9ZAB0), Listeria monocytogenes, Marchantia polymorpha (P12208), Mus musculus (O88696), Mycobacterium tuberculosis (P9WPC5 and P9WPC3), Mycobacterium tuberculosis H37Rv (P9WPC5 and P9WPC3), Myxococcus xanthus, Nicotiana tabacum (P12210), Oryza sativa (P0C312), Paracoccus denitrificans (P54414), Pinus contorta (P36387), Pinus thunbergii (P41609), Populus tremula, Porphyromonas gingivalis, Pseudomonas aeruginosa, Rhodobacter capsulatus, Salmonella enterica subsp. enterica serovar Typhimurium, Shewanella putrefaciens, Solanum lycopersicum (Q42886), Streptococcus pyogenes, Streptococcus salivarius (P36398), Streptomyces coelicolor, Synechococcus sp., Synechococcus sp. (O34125), Synechococcus sp. (P54415), Synechocystis sp. (P54416), Synechocystis sp. (P74467), Synechocystis sp. (Q59993), Treponema pallidum (O84003), Triticum aestivum (P24064), Yersinia enterocolitica (O30612), Yersinia enterocolitica (Q60107), Zea mays (P12340)
Manually annotated by BRENDA team
Guillon, B.; Bulteau, A.L.; Wattenhofer-Donze, M.; Schmucker, S.; Friguet, B.; Puccio, H.; Drapier, J.C.; Bouton, C.
Frataxin deficiency causes upregulation of mitochondrial Lon and ClpP proteases and severe loss of mitochondrial Fe-S proteins
FEBS J.
276
1036-1047
2009
Mus musculus (O88696)
Manually annotated by BRENDA team