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Reference on EC 3.4.21.89 - Signal peptidase I

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Packer, J.C.L.; Andre, D.; Howe, C.J.
Cloning and sequence analysis of a signal peptidase I from the thermophilic cyanobacterium Phormidium laminosum
Plant Mol. Biol.
27
199-204
1995
Phormidium laminosum
Manually annotated by BRENDA team
Tschantz, W.R.; Dalbey, R.E.
Bacterial leader peptidase 1
Methods Enzymol.
244
285-301
1994
Escherichia coli, Escherichia coli MC1061/pRD8
Manually annotated by BRENDA team
Lively, M.O.; Newsome, A.L.; Nusier, M.
Eukaryote microsomal signal peptidases
Methods Enzymol.
244
301-314
1994
Canis lupus familiaris, Gallus gallus
Manually annotated by BRENDA team
Nunnari, J.; Fox, T.D.; Walter, P.
A mitochondrial protease with two catalytic subunits of nonoverlapping specificities
Science
262
1997-2004
1993
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Tschantz, W.R.; Sung, M.; Delgado-Partin, V.M.; Dalbey, R.E.
A serine and a lysine residue implicated in the catalytic mechanism of the Escherichia coli leader peptidase
J. Biol. Chem.
268
27349-27354
1993
Escherichia coli
Manually annotated by BRENDA team
Black, M.T.
Evidence that the catalytic activity of prokaryote leader peptidase depends upon the operation of a serine-lysine catalytic dyad
J. Bacteriol.
175
4957-4961
1993
Escherichia coli
Manually annotated by BRENDA team
Wolfe, P.B.; Zwizinski, C.; Wickner, W.
Purification and characterization of leader peptidase from Escherichia coli
Methods Enzymol.
97
40-46
1983
Escherichia coli
Manually annotated by BRENDA team
Date, T.; Silver, P.; Wickner, W.
Molecular genetics of Escherichia coli leader peptidase
Methods Enzymol.
97
46-57
1983
Escherichia coli
Manually annotated by BRENDA team
Dalbey, R.E.; von Heijne, G.
Signal peptidases in prokaryotes and eukaryotes--a new protease family [published erratum appears in Trends Biochem Sci 1993 Jan;18(1):25]
Trends Biochem. Sci.
17
474-478
1992
Saccharomyces cerevisiae, Gallus gallus, Escherichia coli, Pseudomonas fluorescens, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Dalbey, R.E.
Leader peptidase
Mol. Microbiol.
51
2855-2860
1991
Escherichia coli
Manually annotated by BRENDA team
Muller, M.
Proteolysis in protein import and export: signal peptide processing in eu- and prokaryotes
Experientia
48
118-129
1992
Saccharomyces cerevisiae, Canis lupus familiaris, Gallus gallus, Escherichia coli, Neurospora crassa, Pisum sativum, Rattus norvegicus
Manually annotated by BRENDA team
Anderson, C.M.; Gray, J.
Cleavage of the precursor of pea chloroplast cytochrome f by leader peptidase from Escherichia coli
FEBS Lett.
280
383-386
1991
Escherichia coli
Manually annotated by BRENDA team
Barkocy-Gallagher, G.A.; Bassford, P.J.
Synthesis of precursor maltose-binding protein with proline in the +1 position of the cleavage site interferes with the activity of Escherichia coli signal peptidase I in vivo
J. Biol. Chem.
267
1231-1238
1992
Escherichia coli
Manually annotated by BRENDA team
Wieseler, B.; Schiltz, E.; Muller, M.
Identification and solubilization of a signal peptidase from the phototrophic bacterium Rhodobacter capsulatus
FEBS Lett.
298
273-276
1992
Rhodobacter capsulatus
Manually annotated by BRENDA team
Newsome, A.L.; McLean, J.W.; Lively, M.O.
Molecular cloning of a cDNA encoding the glycoprotein of hen oviduct microsomal signal peptidase
Biochem. J.
282
447-452
1992
Gallus gallus
Manually annotated by BRENDA team
Black, M.T.; Munn, J.G.R.; Allsop, A.E.
On the catalytic mechanism of prokaryotic leader peptidase 1
Biochem. J.
282
539-543
1992
Escherichia coli, Pseudomonas fluorescens
Manually annotated by BRENDA team
Shelness, G.S.; Lin, L.; Nicchitta, C.V.
Membrane topology and biogenesis of eukaryotic signal peptidase
J. Biol. Chem.
268
5201-5208
1993
Canis lupus familiaris
Manually annotated by BRENDA team
Kuo, D.W.; Chan, H.K.; Wilson, C.J.; Griffin, P.R.; Williams, H.; Knight, W.B.
Escherichia coli leader peptidase: production of an active form lacking a requirement for detergent and development of peptide substrates
Arch. Biochem. Biophys.
303
274-280
1993
Escherichia coli
Manually annotated by BRENDA team
Kuo, D.; Weidner, J.; Griffin, P.; Shah, S.K.; Knight, W.B.
Determination of the kinetic parameters of Escherichia coli leader peptidase activity using a continuous assay: the pH dependence and time-dependent inhibition by beta-lactams are consistent with a novel serine protease mechanism
Biochemistry
33
8347-8354
1994
Escherichia coli
Manually annotated by BRENDA team
Kirchweger, R.; Ziegler, E.; Lamphear, B.J.; Waters, D.; Liebig, H.D.; Sommergruber, W.; Sobrino, F.; Hohenadl, C.; Blaas, D.; Rhoads, R.E.; Skern, T.
Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4gamma
J. Virol.
68
5677-5684
1994
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Chatterjee, S.; Suciu, D.; Dalbey, R.E.; Kahn, P.C.; Inouye, M.
Determination of Km and kcat for signal peptidase I using a full length secretory precursor, pro-OmpA-nuclease A
J. Mol. Biol.
254
311-314
1995
Escherichia coli
Manually annotated by BRENDA team
Tschantz, W.R.; Paetzel, M.; Cao, G.; Suciu, D.; Inouye, M.; Dalbey, R.E.
Characterization of a soluble, catalytically active form of Escherichia coli leader peptidase: requirement of detergent or phospholipid for optimal activity
Biochemistry
34
3935-3941
1995
Escherichia coli
Manually annotated by BRENDA team
Kim, Y.T.; Muramatsu, T.; Takahashi, K.
Leader peptidase from Escherichia coli: overexpression, characterization, and inactivation by modification of tryptophan residues 300 and 310 with N-bromosuccinimide
J. Biochem.
117
535-544
1995
Escherichia coli
Manually annotated by BRENDA team
Paetzel, M.; Chernaia, M.; Strynadka, N.; Tschantz, W.; Cao, G.; Dalbey, R.E.; James, M.N.G.
Crystallization of a soluble, catalytically active form of Escherichia coli leader peptidase
Proteins Struct. Funct. Genet.
23
122-125
1995
Escherichia coli
Manually annotated by BRENDA team
Kalies, K.U.; Hartmann, E.
Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex
J. Biol. Chem.
271
3925-3929
1996
Canis lupus familiaris, Homo sapiens
Manually annotated by BRENDA team
Talarico, T.L.; Dev, I.K.; Bassford, P.J.; Ray, R.H.
Inter-molecular degradation of signal peptidase I in vitro
Biochem. Biophys. Res. Commun.
181
650-656
1991
Escherichia coli, Escherichia coli MC1061
Manually annotated by BRENDA team
Wickner, W.; Moore, K.; Dibb, N.; Geissert, D.; Rice, M.
Inhibition of purified Escherichia coli leader peptidase by the leader (signal) peptide of bacteriophage M13 procoat
J. Bacteriol.
169
3821-3822
1987
Escherichia coli
Manually annotated by BRENDA team
Halpin, C.; Elderfield, P.D.; James, H.E.; Zimmermann, R.; Dunbar, B.; Robinson, C.
The reaction specificities of the thylakoidal processing peptidase and Escherichia coli leader peptidase are identical
EMBO J.
82
3917-3921
1989
Escherichia coli
Manually annotated by BRENDA team
Dev, I.K.; Ray, P.H.; Novak, P.
Minimum substrate sequence for signal peptidase I of Escherichia coli
J. Biol. Chem.
265
20069-20072
1990
Escherichia coli
Manually annotated by BRENDA team
Zwizinski, C.; Wickner, W.
Purification and characterization of leader (signal) peptidase from Escherichia coli
J. Biol. Chem.
255
7973-7977
1980
Escherichia coli
Manually annotated by BRENDA team
Wolfe, P.B.; Silver, P.; Wickner, W.
The isolation of homogeneous leader peptidase from a strain of Escherichia coli which overproduces the enzyme
J. Biol. Chem.
257
7898-7902
1982
Escherichia coli, Escherichia coli overproducing
Manually annotated by BRENDA team
Dierstein, R.; Wickner, W.
Requirements for substrate recognition by bacterial leader peptidase
EMBO J.
5
427-431
1986
Escherichia coli
Manually annotated by BRENDA team
Dalbey, R.E.; Wickner, W.
Leader peptidase of Escherichia coli: critical role of a small domain in membrane assembly
Science
235
783-787
1987
Escherichia coli
Manually annotated by BRENDA team
Novak, P.; Dev, I.K.
Degradation of a signal peptide by protease IV and oligopeptidase A
J. Bacteriol.
170
5067-5075
1988
Escherichia coli
Manually annotated by BRENDA team
Guarne, A.; Hampoelz, B.; Glaser, W.; Carpena, X.; Torma, J.; Fita, I.; Skern, T.
Structural and biochemical features distinguish the foot-and-mouth disease virus leader proteinase from other papain-like enzymes
J. Mol. Biol.
302
1227-1240
2000
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Geukens, N.; Frederix, F.; Reekmans, G.; Lammertyn, E.; Van Mellaert, L.; Dehaen, W.; Maes, G.; Anne, J.
Analysis of type I signal peptidase affinity and specificity for preprotein substrates
Biochem. Biophys. Res. Commun.
314
459-467
2004
Escherichia coli, Streptomyces lividans
Manually annotated by BRENDA team
Stein, R.L.; Barbosa, M.D.F.S.; Bruckner, R.
Kinetic and mechanistic studies of signal peptidase I from Escherichia coli
Biochemistry
39
7973-7983
2000
Escherichia coli
Manually annotated by BRENDA team
Gallagher, J.; Kaderbhai, N.N.; Kaderbhai, M.A.
Kinetic constants of signal peptidase I using cytochrome b5 as a precursor substrate
Biochim. Biophys. Acta
1550
1-5
2001
Escherichia coli
Manually annotated by BRENDA team
Zheng, F.; Angleton, E.L.; Lu, J.; Peng, S.B.
In vitro and in vivo self-cleavage of Streptococcus pneumoniae signal peptidase I
Eur. J. Biochem.
269
3969-3977
2002
Streptococcus pneumoniae
Manually annotated by BRENDA team
Chu, H.H.; Hoang, V.; Kreutzmann, P.; Hofemeister, B.; Melzer, M.; Hofemeister, J.
Identification and properties of type I-signal peptidases of Bacillus amyloliquefaciens
Eur. J. Biochem.
269
458-469
2002
Bacillus amyloliquefaciens
Manually annotated by BRENDA team
Bruton, G.; Huxley, A.; O'Hanlon, P.; Orlek, B.; Eggleston, D.; Humphries, J.; Readshaw, S.; West, A.; Ashman, S.; Brown, M.; Moore, K.; Pope, A.; O'Dwyer, K.; Wang, L.
Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to alpha-ketoamide inhibitors
Eur. J. Med. Chem.
38
351-356
2003
Escherichia coli, Staphylococcus aureus
Manually annotated by BRENDA team
Nilsson, IM.; Johnson, A.E.; von Heijne, Gunnar
Cleavage of a tail-anchored protein by signal peptidase
FEBS Lett.
516
106-108
2002
Canis lupus familiaris
Manually annotated by BRENDA team
Peng, S.B.; Wang, L.; Moomaw, J.; Peery, R.B.; Sun, P.M.; Johnson, R.B.; Lu, J.; Treadway, P
Skatrud, P.L.; Wang, Q.M.: Biochemical characterization of signal peptidase I from gram-positive Streptococcus pneumoniae
J. Bacteriol.
183
621-627
2001
Streptococcus pneumoniae
Manually annotated by BRENDA team
Ng, S.Y.M.; Jarrell, K.F.
Cloning and characterization of archael type I signal peptidase from Methanococcus voltae
J. Bacteriol.
185
5936-5942
2003
Methanococcus voltae, Methanococcus voltae PS
Manually annotated by BRENDA team
Ichihara, S.; Suzuki, T.; Suzuki, M.; Mizushima, S.
Molecular cloning and sequencing of the sppA gene and characterization of the encoded protease IV, a signal peptide peptidase, of Escherichia coli
J. Biol. Chem.
261
9405-9411
1986
Escherichia coli
Manually annotated by BRENDA team
Cioffi, J.A.; Allen, K.L.; Lively, M.O.; Kemper, B.
Parallel effects of signal peptide hydrophobic core modifications on co-translational translocation and post-translational cleavage by purified signal peptidase
J. Biol. Chem.
264
15052-15058
1989
Gallus gallus
Manually annotated by BRENDA team
Engel, L.S.; Hill, J.M.; Caballero, A.R.; Green, L.C.; O'Callaghan, R.J.
Protease IV, a unique extracellular protease and virulence factor from Pseudomonas aeruginosa
J. Biol. Chem.
273
16792-16797
1998
Pseudomonas aeruginosa, Pseudomonas aeruginosa PA103-29
Manually annotated by BRENDA team
Bolhuis, A.; Matzen, A.; Hyyrylainen, H.L.; Kontinen, V.P.; Meima, R.; Chapuis, J.; Venema, G.; Bron, S.; Freudl, R.; van Dijl, J.M.
Signal peptide peptidase- and ClpP-like proteins of Bacillus subtilis required for efficient translocation and processing of secretory proteins
J. Biol. Chem.
274
24585-24592
1999
Bacillus subtilis
Manually annotated by BRENDA team
Carlos, J.L.; Paetzel, M.; Brubaker, G.; Karla, A.; Ashwell, C.M.; Lively, M.O.; Cao, G.; Bullinger, P.; Dalbey, R.E.
The role of the membrane-spanning domain of type I signal peptidases in substrate cleavage site selection
J. Biol. Chem.
275
38813-38822
2000
Bacillus subtilis (P28628), Bacillus subtilis, Escherichia coli (P00803), Escherichia coli
Manually annotated by BRENDA team
Klenotic, P.A; Carlos, J.L.; Samuelson, J.C.; Schuenemann, T.A.; Tschantz, W.R.; Paetzel, M.; Strynadka, N.C.J.; Dalbey, R.E.
The role of the conserved box E residues in the active site of the Escherichia coli type I signal peptidase
J. Biol. Chem.
275
6490-6498
2000
Escherichia coli
Manually annotated by BRENDA team
Sharkov, N.A.; Cai, D.
Discovery of substrate for type I signal peptidase SpsB from Staphylococcus aureus
J. Biol. Chem.
277
5796-5803
2002
Staphylococcus aureus
Manually annotated by BRENDA team
Paetzel, M.; Dalbey, R.E.; Strynadka, N.C.J.
Crystal structures of a bacterial signal peptidase in complex with a beta-lactam inhibitor
Nature
396
186-190
1998
Escherichia coli
Manually annotated by BRENDA team
Suciu, D.; Chatterjee, S.; Inouye, M.
Catalytic efficiency of signal peptidase I of Escherichia coli is comparable to that of members of the serine protease family
Protein Eng.
10
1057-1060
1997
Escherichia coli
Manually annotated by BRENDA team
Dalbey, R.E.; Lively, M.O.; Bron,S.; Van Diijl, J.M.
The chemistry and enzymology of the type I signal peptidases
Protein Sci.
6
1129-1138
1997
Bacillus amyloliquefaciens, Bacillus licheniformis, Bacillus subtilis, Bradyrhizobium japonicum, Caenorhabditis elegans (P34525), Canis lupus familiaris, Escherichia coli, Gallus gallus, Haemophilus influenzae, Homo sapiens (Q15005), Methanocaldococcus jannaschii, Mycobacterium tuberculosis, no activity in Mycoplasma genitalium, Phormidium laminosum, Pseudomonas fluorescens, Rana sp., Rattus norvegicus, Rhodobacter capsulatus (Q52697), Saccharomyces cerevisiae, Salmonella enterica subsp. enterica serovar Typhimurium, Schizosaccharomyces pombe (Q10259), Staphylococcus aureus, [Bacillus] caldolyticus
Manually annotated by BRENDA team
Paetzel, M.; Strynadka, N.C.J.
Common protein architecture and binding sites in proteases utilizing a Ser/Lys dyad mechanism
Protein Sci.
8
2533-2536
1999
Escherichia coli
Manually annotated by BRENDA team
Michaelis, G.; Esser, K.; Tursun, B.; Stohn, J.P.; Hanson, S.; Pratje, E.
Mitochondrial signal peptidases of yeast: the rhomboid peptidase Pcp1 and its substrate cytochrome c peroxidase
Gene
354
58-63
2005
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Wang, Y.; Bruckner, R.; Stein, R.L.
Regulation of signal peptidase by phospholipids in membrane: characterization of phospholipid bilayer-incorporated Escherichia coli signal peptidase
Biochemistry
43
265-270
2004
Escherichia coli
Manually annotated by BRENDA team
Kim, Y.T.; Kurita, R.; Kojima, M.; Nishii, W.; Tanokura, M.; Muramatsu, T.; Ito, H.; Takahashi, K.
Identification of arginine residues important for the activity of Escherichia coli signal peptidase I
Biol. Chem.
385
381-388
2004
Escherichia coli
Manually annotated by BRENDA team
Bardy, S.L.; Ng, S.Y.; Carnegie, D.S.; Jarrell, K.F.
Site-directed mutagenesis analysis of amino acids critical for activity of the type I signal peptidase of the archaeon Methanococcus voltae
J. Bacteriol.
187
1188-1191
2005
Methanococcus voltae
Manually annotated by BRENDA team
Fine, A.; Irihimovitch, V.; Dahan, I.; Konrad, Z.; Eichler, J.
Cloning, expression, and purification of functional Sec11a and Sec11b, type I signal peptidases of the archaeon Haloferax volcanii
J. Bacteriol.
188
1911-1919
2006
Haloferax volcanii
Manually annotated by BRENDA team
Vauloup-Fellous, C.; Pene, V.; Garaud-Aunis, J.; Harper, F.; Bardin, S.; Suire, Y.; Pichard, E.; Schmitt, A.; Sogni, P.; Pierron, G.; Briand, P.; Rosenberg, A.R.
Signal peptide peptidase-catalyzed cleavage of hepatitis C virus core protein is dispensable for virus budding, but destabilizes the viral capsid
J. Biol. Chem.
22
27679-27692
2006
Mesocricetus auratus
Manually annotated by BRENDA team
Kulanthaivel, P.; Kreuzman, A.J.; Strege, M.A.; Belvo, M.D.; Smitka, T.A.; Clemens, M.; Swartling, J.R.; Minton, K.L.; Zheng, F.; Angleton, E.L.; Mullen, D.; Jungheim, L.N.; Klimkowski, V.J.; Nicas, T.I.; Thompson, R.C.; Peng, S.B.
Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I
J. Biol. Chem.
279
36250-36258
2004
Streptococcus pneumoniae, Escherichia coli
Manually annotated by BRENDA team
Karla, A.; Lively, M.O.; Paetzel, M.; Dalbey, R.
The identification of residues that control signal peptidase cleavage fidelity and substrate specificity
J. Biol. Chem.
280
6731-6741
2005
Escherichia coli (P00803)
Manually annotated by BRENDA team
Matsumi, R.; Atomi, H.; Imanaka, T.
Identification of the amino acid residues essential for proteolytic activity in an archaeal signal peptide peptidase
J. Biol. Chem.
281
10533-10539
2006
Thermococcus kodakarensis
Manually annotated by BRENDA team
Sharma, S.; Pradhan, A.; Chauhan, V.S.; Tuteja, R.
Isolation and characterization of type I signal peptidase of different malaria parasites
J. Biomed. Biotechnol.
2005
301-309
2005
Plasmodium yoelii (Q5Q1M8), Plasmodium yoelii, Plasmodium knowlesi (Q5Q1M9), Plasmodium knowlesi, Plasmodium falciparum (Q6PSM6), Plasmodium falciparum
Manually annotated by BRENDA team
Inoue, K.; Baldwin, A.J.; Shipman, R.L.; Matsui, K.; Theg, S.M.; Ohme-Takagi, M.
Complete maturation of the plastid protein translocation channel requires a type I signal peptidase
J. Cell Biol.
171
425-430
2005
Arabidopsis thaliana
Manually annotated by BRENDA team
Majeau, N.; Gagne, V.; Bolduc, M.; Leclerc, D.
Signal peptide peptidase promotes the formation of hepatitis C virus non-enveloped particles and is captured on the viral membrane during assembly
J. Gen. Virol.
86
3055-3064
2005
Homo sapiens
Manually annotated by BRENDA team
Heimann, M.; Roman-Sosa, G.; Martoglio, B.; Thiel, H.J.; Rumenapf, T.
Core protein of pestiviruses is processed at the C terminus by signal peptide peptidase
J. Virol.
80
1915-1921
2006
Classical swine fever virus
Manually annotated by BRENDA team
Lammertyn, E.; Van Mellaert, L.; Meyen, E.; Lebeau, I.; De Buck, E.; Anne, J.; Geukens, N.
Molecular and functional characterization of type I signal peptidase from Legionella pneumophila
Microbiology
150
1475-1483
2004
Legionella pneumophila
Manually annotated by BRENDA team
Bonnemain, C.; Raynaud, C.; Reglier-Poupet, H.; Duball, I.; Frehel, C.; Lety, M.A.; Berche, P.; Charbit, A.
Differential roles of multiple signal peptidases in the virulence of Listeria monocytogenes
Mol. Microbiol.
51
1251-1266
2004
Listeria monocytogenes
Manually annotated by BRENDA team
Loureiro, J.; Lilley, B.N.; Spooner, E.; Noriega, V.; Tortorella, D.; Ploegh, H.L.
Signal peptide peptidase is required for dislocation from the endoplasmic reticulum
Nature
441
894-897
2006
Homo sapiens
Manually annotated by BRENDA team
Nahrstedt, H.; Wittchen, K.; Rachman, M.A.; Meinhardt, F.
Identification and functional characterization of a type I signal peptidase gene of Bacillus megaterium DSM319
Appl. Microbiol. Biotechnol.
64
243-249
2004
Priestia megaterium (Q845L3), Priestia megaterium
Manually annotated by BRENDA team
Musial-Siwek, M.; Kendall, D.A.; Yeagle, P.L.
Solution NMR of signal peptidase, a membrane protein
Biochim. Biophys. Acta
1778
937-944
2008
Escherichia coli
Manually annotated by BRENDA team
Buzder-Lantos, P.; Bockstael, K.; Anne, J.; Herdewijn, P.
Substrate based peptide aldehyde inhibits bacterial type I signal peptidase
Bioorg. Med. Chem. Lett.
19
2880-2883
2009
Staphylococcus aureus
Manually annotated by BRENDA team
Musial-Siwek, M.; Yeagle, P.L.; Kendall, D.A.
A small subset of signal peptidase residues are perturbed by signal peptide binding
Chem. Biol. Drug Des.
72
140-146
2008
Escherichia coli
Manually annotated by BRENDA team
Shipman, R.L.; Inoue, K.
Suborganellar localization of plastidic type I signal peptidase 1 depends on chloroplast development
FEBS Lett.
583
938-942
2009
Arabidopsis thaliana (Q8H0W1)
Manually annotated by BRENDA team
Pene, V.; Hernandez, C.; Vauloup-Fellous, C.; Garaud-Aunis, J.; Rosenberg, A.R.
Sequential processing of hepatitis C virus core protein by host cell signal peptidase and signal peptide peptidase: a reassessment
J. Viral Hepat.
16
705-715
2009
Homo sapiens
Manually annotated by BRENDA team
Kaderbhai, N.N.; Harding, V.; Kaderbhai, M.A.
Signal peptidase I-mediated processing of an engineered mammalian cytochrome b(5) precursor is an exocytoplasmic post-translocational event in Escherichia coli
Mol. Membr. Biol.
25
388-399
2008
Escherichia coli (P00803), Escherichia coli
Manually annotated by BRENDA team
Luo, C.; Roussel, P.; Dreier, J.; Page, M.G.; Paetzel, M.
Crystallographic analysis of bacterial signal peptidase in ternary complex with arylomycin A2 and a beta-sultam inhibitor
Biochemistry
48
8976-8984
2009
Escherichia coli (P00803), Escherichia coli
Manually annotated by BRENDA team
Harris, D.A.; Powers, M.E.; Romesberg, F.E.
Synthesis and biological evaluation of penem inhibitors of bacterial signal peptidase
Bioorg. Med. Chem. Lett.
19
3787-3790
2009
Staphylococcus epidermidis RP62A
Manually annotated by BRENDA team
Taheri, T.; Salmanian, A.H.; Gholami, E.; Doustdari, F.; Zahedifard, F.; Rafati, S.
Leishmania major: Disruption of signal peptidase type I and its consequences on survival, growth and infectivity
Exp. Parasitol.
126
135-145
2010
Leishmania major, Leishmania major MHOM/IL/80/Friedlin
Manually annotated by BRENDA team
Rao, S.; Bockstael, K.; Nath, S.; Engelborghs, Y.; Anne, J.; Geukens, N.
Enzymatic investigation of the Staphylococcus aureus type I signal peptidase SpsB - implications for the search for novel antibiotics
FEBS J.
276
3222-3234
2009
Staphylococcus aureus
Manually annotated by BRENDA team
Bockstael, K.; Geukens, N.; Rao, C.V.; Herdewijn, P.; Anne, J.; Van Aerschot, A.
An easy and fast method for the evaluation of Staphylococcus epidermidis type I signal peptidase inhibitors
J. Microbiol. Methods
78
231-237
2009
Staphylococcus epidermidis
Manually annotated by BRENDA team
Bockstael, K.; Geukens, N.; Van Mellaert, L.; Herdewijn, P.; Anne, J.; Van Aerschot, A.
Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis
Microbiology
155
3719-3729
2009
Staphylococcus epidermidis
Manually annotated by BRENDA team
Shipman-Roston, R.L.; Ruppel, N.J.; Damoc, C.; Phinney, B.S.; Inoue, K.
The significance of protein maturation by plastidic type I signal peptidase 1 for thylakoid development in Arabidopsis chloroplasts
Plant Physiol.
152
1297-1308
2010
Arabidopsis thaliana
Manually annotated by BRENDA team
Crauste, C.; Froeyen, M.; Anne, J.; Herdewijn, P.
Asymmetric synthesis of new beta-lactam lipopeptides as bacterial signal peptidase I inhibitors
Eur. J. Org. Chem.
2011
3437-3449
2011
Staphylococcus aureus
-
Manually annotated by BRENDA team
Powers, M.E.; Smith, P.A.; Roberts, T.C.; Fowler, B.J.; King, C.C.; Trauger, S.A.; Siuzdak, G.; Romesberg, F.E.
Type I signal peptidase and protein secretion in Staphylococcus epidermidis
J. Bacteriol.
193
340-348
2011
Staphylococcus epidermidis
Manually annotated by BRENDA team
Byun, H.; Halani, N.; Mertz, J.A.; Ali, A.F.; Lozano, M.M.; Dudley, J.P.
Retroviral Rem protein requires processing by signal peptidase and retrotranslocation for nuclear function
Proc. Natl. Acad. Sci. USA
107
12287-12292
2010
Mus musculus
Manually annotated by BRENDA team
De Bona, P.; Deshmukh, L.; Gorbatyuk, V.; Vinogradova, O.; Kendall, D.A.
Structural studies of a signal peptide in complex with signal peptidase I cytoplasmic domain: The stabilizing effect of membrane-mimetics on the acquired fold
Proteins
80
807-817
2011
Escherichia coli
Manually annotated by BRENDA team
Fink-Lavi, E.; Eichler, J.
Identification of residues essential for the catalytic activity of Sec11b, one of the two type I signal peptidases of Haloferax volcanii
FEMS Microbiol. Lett.
278
257-260
2007
Haloferax volcanii (D4GYJ8), Haloferax volcanii, Haloferax volcanii DSM 3757 (D4GYJ8)
Manually annotated by BRENDA team
Ting, Y.; Batot, G.; Baker, E.; Young, P.
Expression, purification and crystallization of a membrane-associated, catalytically active type I signal peptidase from Staphylococcus aureus
Acta Crystallogr. Sect. F
71
61-65
2015
Staphylococcus aureus, Staphylococcus aureus Newman
Manually annotated by BRENDA team
Smith, P.A.; Romesberg, F.E.
Mechanism of action of the arylomycin antibiotics and effects of signal peptidase I inhibition
Antimicrob. Agents Chemother.
56
5054-5060
2012
Escherichia coli, Staphylococcus aureus
Manually annotated by BRENDA team
Zhang, W.; Xia, Y.
ER type I signal peptidase subunit (LmSPC1) is essential for the survival of Locusta migratoria manilensis and affects moulting, feeding, reproduction and embryonic development
Insect Mol. Biol.
23
269-285
2014
Locusta migratoria manilensis (R9UE57), Locusta migratoria manilensis
Manually annotated by BRENDA team
Ollinger, J.; OMalley, T.; Ahn, J.; Odingo, J.; Parish, T.
Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions
J. Bacteriol.
194
2614-2619
2012
Mycobacterium tuberculosis (P9WKA1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKA1)
Manually annotated by BRENDA team
Schallenberger, M.A.; Niessen, S.; Shao, C.; Fowler, B.J.; Romesberg, F.E.
Type I signal peptidase and protein secretion in Staphylococcus aureus
J. Bacteriol.
194
2677-2686
2012
Staphylococcus aureus, Staphylococcus aureus NCTC 8325
Manually annotated by BRENDA team
Waite, R.D.; Rose, R.S.; Rangarajan, M.; Aduse-Opoku, J.; Hashim, A.; Curtis, M.A.
Pseudomonas aeruginosa possesses two putative type I signal peptidases, LepB and PA1303, each with distinct roles in physiology and virulence
J. Bacteriol.
194
4521-4536
2012
Pseudomonas aeruginosa (Q9I441), Pseudomonas aeruginosa (Q9I5G7), Pseudomonas aeruginosa
Manually annotated by BRENDA team
Renier, S.; Chafsey, I.; Chambon, C.; Caccia, N.; Charbit, A.; Hebraud, M.; Desvaux, M.
Contribution of the multiple Type I signal peptidases to the secretome of Listeria monocytogenes: Deciphering their specificity for secreted exoproteins by exoproteomic analysis
J. Proteomics
117
95-105
2015
Listeria monocytogenes
Manually annotated by BRENDA team
Midorikawa, T.; Endow, J.K.; Dufour, J.; Zhu, J.; Inoue, K.
Plastidic type I signal peptidase 1 is a redox-dependent thylakoidal processing peptidase
Plant J.
80
592-603
2014
Arabidopsis thaliana (Q8H0W1), Arabidopsis thaliana
Manually annotated by BRENDA team
Bhanu, M.; Kendall, D.
Fluorescence spectroscopy of soluble E. coli SPase I DELTA2-75 reveals conformational changes in response to ligand binding
Proteins
82
596-606
2014
Escherichia coli (A0A140N8W1), Escherichia coli
Manually annotated by BRENDA team
Yeh, C.H.; Walsh, S.I.; Craney, A.; Tabor, M.G.; Voica, A.F.; Adhikary, R.; Morris, S.E.; Romesberg, F.E.
Optimization of a beta-lactam scaffold for antibacterial activity via the inhibition of bacterial type I signal peptidase
ACS Med. Chem. Lett.
9
376-380
2018
Escherichia coli (P00803), Escherichia coli MG1655 (P00803), Staphylococcus epidermidis, Staphylococcus epidermidis RP26A, Yersinia pestis, Yersinia pestis KIM+6
Manually annotated by BRENDA team
Steed, D.B.; Liu, J.; Wasbrough, E.; Miller, L.; Halasohoris, S.; Miller, J.; Somerville, B.; Hershfield, J.R.; Romesberg, F.E.
Origins of Yersinia pestis sensitivity to the arylomycin antibiotics and the inhibition of type I signal peptidase
Antimicrob. Agents Chemother.
59
3887-3898
2015
Yersinia pestis
Manually annotated by BRENDA team
Zalucki, Y.M.; Jennings, M.P.
Signal peptidase I processed secretory signal sequences selection for and against specific amino acids at the second position of mature protein
Biochem. Biophys. Res. Commun.
483
972-977
2017
Methanococcus voltae, Sulfurisphaera tokodaii, Escherichia coli (P00803), Saccharomyces cerevisiae (P15367), Saccharomyces cerevisiae, Bacillus subtilis (P28628), Bacillus subtilis 168 (P28628), Sulfurisphaera tokodaii 7, Methanococcus voltae A3, Saccharomyces cerevisiae ATCC 204508 (P15367)
Manually annotated by BRENDA team
Musik, J.E.; Zalucki, Y.M.; Day, C.J.; Jennings, M.P.
Efficient function of signal peptidase 1 of Escherichia coli is partly determined by residues in the mature N-terminus of exported proteins
Biochim. Biophys. Acta
1861
1018-1022
2019
Escherichia coli (P00803), Escherichia coli
Manually annotated by BRENDA team
Walsh, S.I.; Craney, A.; Romesberg, F.E.
Not just an antibiotic target exploring the role of type I signal peptidase in bacterial virulence
Bioorg. Med. Chem.
24
6370-6378
2016
Actinomyces sp., Bacillus anthracis (A0A1S0QR24), Bacillus cereus (A0A7D3YGV4), Bacillus cereus 03BB108 (A0A7D3YGV4), Clostridioides difficile (A0A031W9H6), Corynebacterium diphtheriae, Enterococcus faecalis (A0A1B4XP47), Enterococcus sp., Escherichia coli (P00803), Lacticaseibacillus rhamnosus (A0A180C927), Listeria monocytogenes, Pseudomonas aeruginosa (Q9I5G7), Pseudomonas aeruginosa 1C (Q9I5G7), Pseudomonas aeruginosa ATCC 15692 (Q9I5G7), Pseudomonas aeruginosa CIP 104116 (Q9I5G7), Pseudomonas aeruginosa DSM 22644 (Q9I5G7), Pseudomonas aeruginosa JCM 14847 (Q9I5G7), Pseudomonas aeruginosa LMG 12228 (Q9I5G7), Pseudomonas aeruginosa PRS 101 (Q9I5G7), Staphylococcus aureus (P0A070), Staphylococcus epidermidis (Q5HQJ6), Staphylococcus epidermidis ATCC 35984 (Q5HQJ6), Streptococcus agalactiae, Streptococcus gallolyticus, Streptococcus pneumoniae, Streptococcus pyogenes (A0A4U7IU30)
Manually annotated by BRENDA team
Bochtler, M.; Mizgalska, D.; Veillard, F.; Nowak, M.L.; Houston, J.; Veith, P.; Reynolds, E.C.; Potempa, J.
The Bacteroidetes Q-rule pyroglutamate in signal peptidase I substrates
Front. Microbiol.
9
230
2018
Porphyromonas gingivalis (Q7MTG0), Porphyromonas gingivalis W83 (Q7MTG0), Porphyromonas gingivalis ATCC BAA-308 (Q7MTG0)
Manually annotated by BRENDA team
Endow, J.K.; Singhal, R.; Fernandez, D.E.; Inoue, K.
Chaperone-assisted post-translational transport of plastidic type I signal peptidase 1
J. Biol. Chem.
290
28778-28791
2015
Arabidopsis thaliana (Q8H0W1), Arabidopsis thaliana
Manually annotated by BRENDA team
Hazenbos, W.L.; Skippington, E.; Tan, M.W.
Staphylococcus aureus type I signal peptidase essential or not essential, thats the question
Microb. Cell
4
108-111
2017
Staphylococcus aureus (P0A070), Staphylococcus aureus
Manually annotated by BRENDA team
Aynapudi, J.; El-Rami, F.; Ge, X.; Stone, V.; Zhu, B.; Kitten, T.; Xu, P.
Involvement of signal peptidase I in Streptococcus sanguinis biofilm formation
Microbiology
163
1306-1318
2017
Streptococcus sanguinis (A3CKV0), Streptococcus sanguinis, Streptococcus sanguinis SK36 (A3CKV0)
Manually annotated by BRENDA team