Reference on EC 3.4.21.78 - granzyme A
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Odake, S.; Kam, C.M.; Narasimhan, L.; Poe, M.; Blake, J.T.; Krahenbuhl, O.; Tschopp, J.; Powers, J.C.
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins
Biochemistry
30
2217-2227
1991
Homo sapiens, Mus musculus
Gershenfeld, H.K.; Hershberger, R.J.; Shows, T.B.; Weissman, I.L.
Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease
Proc. Natl. Acad. Sci. USA
85
1184-1188
1988
Homo sapiens
Simon, M.M.; Hoschutzky, H.; Fruth, U.; Simon, H.G.; Kramer, M.D.
Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes
EMBO J.
5
3267-3274
1986
Mus musculus
Simon, M.M.; Kramer, M.D.
Granzyme A
Methods Enzymol.
244
68-79
1994
Homo sapiens, Mus musculus
Kummer, J.A.; Kamp, A.M.; Citarella, F.; Horrevoets, A.J.G.; Hack, C.E.
Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C
J. Biol. Chem.
271
9281-9286
1996
Homo sapiens
Vettel, U.; Brunner, G.; Bar-Shavit, R.; Vlodavsky, I.; Kramer, M.D.
Charge-dependent binding of granzyme A (MTSP-1) to basement membranes
Eur. J. Immunol.
23
279-282
1993
Mus musculus
Irmler, M.; Hertig, S.; MacDonald, H.R.; Sadoul, R.; Becherer, J.D.; Proudfoot, A.; Solari, R.; Tschopp, J.
Granzyme A is an interleukin 1 beta-converting enzyme
J. Exp. Med.
181
1917-1922
1995
Mammalia
Spaeny-Dekking, E.H.A.; Kamp, A.M.; Froelich, C.J.; Hack, C.E.
Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors
Blood
95
1465-1472
2000
Homo sapiens
Bell, J.K.; Goetz, D.H.; Mahrus, S.; Harris, J.L.; Fletterick, R.J.; Craik, C.S.
The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity
Nat. Struct. Biol.
10
527-534
2003
Homo sapiens
Hink-Schauer, C.; Estebanez-Perpina, E.; Kurschus, F.C.; Bode, W.; Jenne, D.E.
Crystal structure of the apoptosis-inducing human granzyme A dimer
Nat. Struct. Biol.
10
535-540
2003
Homo sapiens
Beresford, P.J.; Kam, C.M.; Powers, J.C.; Lieberman, J.
Recombinant human granzyme A binds to putative HLA-associated proteins and cleaves one of them
Proc. Natl. Acad. Sci. USA
94
9285-9290
1997
Homo sapiens
Grossman, W.J.; Verbsky, J.W.; Tollefsen, B.L.; Kemper, C.; Atkinson, J.P.; Ley, T.J.
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells
Blood
104
2840-2848
2004
Homo sapiens
Mahrus, S.; Craik, C.S.
Selective chemical functional probes of granzymes A and B reveal granzyme B Is a major effector of natural killer cell-mediated lysis of target cells
Chem. Biol.
12
567-577
2005
Homo sapiens
Zhu, P.; Zhang, D.; Chowdhury, D.; Martinvalet, D.; Keefe, D.; Shi, L.; Lieberman, J.
Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70
EMBO Rep.
7
431-437
2006
Homo sapiens
Martinvalet, D.; Zhu, P.; Lieberman, J.
Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis
Immunity
22
355-370
2005
Homo sapiens
Bade, B.; Boettcher, H.E.; Lohrmann, J.; Hink-Schauer, C.; Bratke, K.; Jenne, D.E.; Virchow, J.C., Jr.; Luttmann, W.
Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes
Int. Immunol.
17
1419-1428
2005
Homo sapiens (P51124)
Pardo, J.; Bosque, A.; Brehm, R.; Wallich, R.; Naval, J.; Mullbacher, A.; Anel, A.; Simon, M.M.
Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis
J. Cell Biol.
167
457-468
2004
Mus musculus
Shacklett, B.L.; Cox, C.A.; Quigley, M.F.; Kreis, C.; Stollman, N.H.; Jacobson, M.A.; Andersson, J.; Sandberg, J.K.; Nixon, D.F.
Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection
J. Immunol.
173
641-648
2004
Homo sapiens
Vernooy, J.H.; Moeller, G.M.; van Suylen, R.J.; van Spijk, M.P.; Cloots, R.H.; Hoet, P.H.; Pennings, H.J.; Wouters, E.F.
Increased granzyme A expression in type II pneumocytes of patients with severe chronic obstructive pulmonary disease
Am. J. Respir. Crit. Care Med.
175
464-472
2007
Homo sapiens (P12544), Homo sapiens
Buzza, M.S.; Bird, P.I.
Extracellular granzymes: current perspectives
Biol. Chem.
387
827-837
2006
Homo sapiens (P12544)
Hirayasu, H.; Yoshikawa, Y.; Tsuzuki, S.; Fushiki, T.
A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis
Biosci. Biotechnol. Biochem.
71
234-237
2007
Rattus norvegicus (Q8CJF4)
Baschuk, N.; Utermoehlen, O.; Gugel, R.; Warnecke, G.; Karow, U.; Paulsen, D.; Brombacher, F.; Kroenke, M.; Deppert, W.
Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice
Cancer Immunol. Immunother.
56
1625-1636
2007
Mus musculus (P11032)
Hochegger, K.; Eller, P.; Huber, J.M.; Bernhard, D.; Mayer, G.; Zlabinger, G.J.; Rosenkranz, A.R.
Expression of granzyme A in human polymorphonuclear neutrophils
Immunology
121
166-173
2007
Homo sapiens (P12544), Homo sapiens
Kaiserman, D.; Bird, C.H.; Sun, J.; Matthews, A.; Ung, K.; Whisstock, J.C.; Thompson, P.E.; Trapani, J.A.; Bird, P.I.
The major human and mouse granzymes are structurally and functionally divergent
J. Cell Biol.
175
619-630
2006
Mus musculus (P11032), Mus musculus, Homo sapiens (P12544), Homo sapiens
Myoumoto, A.; Nakatani, K.; Koshimizu, T.; Matsubara, H.; Adachi, S.; Tsujimoto, G.
Glucocorticoid-induced granzyme A expression can be used as a marker of glucocorticoid sensitivity for acute lymphoblastic leukemia therapy
J. Hum. Genet.
52
328-333
2007
Homo sapiens (P12544), Homo sapiens
Lee-Kirsch, M.A.; Chowdhury, D.; Harvey, S.; Gong, M.; Senenko, L.; Engel, K.; Pfeiffer, C.; Hollis, T.; Gahr, M.; Perrino, F.W.; Lieberman, J.; Hubner, N.
A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus
J. Mol. Med.
85
531-537
2007
Homo sapiens (P12544)
Martinvalet, D.; Dykxhoorn, D.M.; Ferrini, R.; Lieberman, J.
Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death
Cell
133
681-692
2008
Homo sapiens
Yoshikawa, Y.; Hirayasu, H.; Tsuzuki, S.; Fushiki, T.
Granzyme A and thrombin differentially promote the release of interleukin-8 from alveolar epithelial A549 cells
Cytotechnology
62
325-332
2010
Homo sapiens
Van Damme, P.; Maurer-Stroh, S.; Hao, H.; Colaert, N.; Timmerman, E.; Eisenhaber, F.; Vandekerckhove, J.; Gevaert, K.
The substrate specificity profile of human granzyme A
Biol. Chem.
391
983-997
2010
Homo sapiens
Ilzecka, J.
Granzymes A and B levels in serum of patients with amyotrophic lateral sclerosis
Clin. Biochem.
44
650-653
2011
Homo sapiens
Huang, R.; Zhong, S.; Liu, H.; Kong, R.; Wang, Y.; Hu, W.; Guo, Q.
Identification and characterization of common carp (Cyprinus carpio L.) granzyme A/K, a cytotoxic cell granule-associated serine protease
Fish Shellfish Immunol.
29
388-398
2010
Cyprinus carpio (D8WWX5), Cyprinus carpio
Grodzovski, I.; Lichtenstein, M.; Galski, H.; Lorberboum-Galski, H.
IL-2-granzyme A chimeric protein overcomes multidrug resistance (MDR) through a caspase 3-independent apoptotic pathway
Int. J. Cancer
128
1966-1980
2011
Homo sapiens
Hartmann, W.; Marsland, B.J.; Otto, B.; Urny, J.; Fleischer, B.; Korten, S.
A novel and divergent role of granzyme A and B in resistance to helminth infection
J. Immunol.
186
2472-2481
2011
Mus musculus
Arias, M.A.; Jimenez de Baguees, M.P.; Aguilo, N.; Menao, S.; Hervas-Stubbs, S.; de Martino, A.; Alcaraz, A.; Simon, M.M.; Froelich, C.J.; Pardo, J.
Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis
Cell Rep.
8
420-429
2014
Mus musculus (P11032), Mus musculus, Mus musculus B6 (P11032)
Kaiserman, D.; Stewart, S.E.; Plasman, K.; Gevaert, K.; Van Damme, P.; Bird, P.I.
Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A
J. Biol. Chem.
289
9408-9417
2014
Mus musculus, Homo sapiens (P12544), Homo sapiens
van den Boogaard, F.E.; van Gisbergen, K.P.; Vernooy, J.H.; Medema, J.P.; Roelofs, J.J.; van Zoelen, M.A.; Endeman, H.; Biesma, D.H.; Boon, L.; Vant Veer, C.; de Vos, A.F.; van der Poll, T.
Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia
Am. J. Physiol. Lung Cell Mol. Physiol.
311
L507-L516
2016
Mus musculus (P11032), Homo sapiens (P12544), Homo sapiens, Mus musculus C57BL/6 (P11032)
Lee, P.; Park, B.; Chi, S.; Bae, K.; Kim, S.; Cho, S.; Kang, S.; Kim, J.; Park, S.
Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells
BMB Rep.
49
560-565
2016
Homo sapiens (P12544)
Cheuk, S.; Martini, E.; Bergh, K.; Chang, D.; Rethi, B.; Staehle, M.; Eidsmo, L.
Granzyme A potentiates chemokine production in IL-17-stimulated keratinocytes
Exp. Dermatol.
26
824-827
2017
Homo sapiens (P12544)
Velaga, S.; Ukena, S.; Dringenberg, U.; Alter, C.; Pardo, J.; Kershaw, O.; Franzke, A.
Granzyme a is required for regulatory T-cell mediated prevention of gastrointestinal graft-versus-host disease
PLoS ONE
10
e0124927
2015
Mus musculus (P11032), Mus musculus
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