Any feedback?
Information on EC 3.4.21.75 - Furin
for references in articles please use BRENDA:EC3.4.21.75Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
3.4.21.75 FurinSpecify your search results
Word Map
- 3.4.21.75
- proproteins
- sars-cov-2
- covid-19
- metalloproteinase
- ectodomain
- spike
- endoprotease
- coronavirus
- viruses
-
trans-golgi
-
disintegrin
- adam17
- ace2
- pandemic
- tmprss2
- neuropeptides
- endosomes
-
neuroendocrine
-
endoproteolytic
- propeptide
- proinsulin
- zymogen
- prodomain
- mt1-mmp
- virion
- anthrax
- subtilisins
- proglucagon
- proopiomelanocortin
-
exotoxin
-
uncleaved
- alpha1-antitrypsin
- prorenin
-
baffs
- portland
- betacoronavirus
- prostasin
-
secretogranin
-
alpha-amidating
-
juxtamembrane
- pharmacology
-
sds-stable
- medicine
-
corticotrophs
-
polybasic
- prosegment
-
monobasic
- drug development
- industry
- mers-cov
- pcsk9
- paramyxoviruses
-
membrane-type
-
subtilase
- analysis
The enzyme appears in viruses and cellular organisms
Synonyms
furin, sheddase, prohormone convertase, furin a, furin protease, proconvertase, subtilisin-like proprotein convertase, furin-like protease, furin convertase, kpc-1, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Dibasic processing enzyme
-
-
-
-
PACE
-
-
-
-
Paired basic amino acid cleaving enzyme
-
-
-
-
Paired basic amino acid converting enzyme
-
-
-
-
Paired basic amino acid residue cleaving enzyme
-
-
-
-
PC1
-
-
-
-
prohormone convertase
-
-
-
-
Proprotein convertase
-
-
-
-
Serine proteinase PACE
-
-
-
-
SPC3
-
-
-
-
Trans golgi network protease furin
-
-
-
-
additional information
furin belongs to the family of proprotein convertase subtilisin/kexin type proteases
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
141760-45-4
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
prohormone convertases specificities for prohormone cleavage, overview
-
-
?
additional information
?
-
-
prohormone convertases specificities for prohormone cleavage, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
prohormone convertases specificities for prohormone cleavage, overview
-
-
?
additional information
?
-
-
prohormone convertases specificities for prohormone cleavage, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Missed
Distribution of furin, TNF-?, and TGF-?2 in the endometrium of missed abortion and voluntary first trimester termination cases.
Acute Kidney Injury
Hemojuvelin Modulates Iron Stress During Acute Kidney Injury: Improved by Furin Inhibitor.
adam 17 endopeptidase deficiency
Short-term TNF? shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.
Adenocarcinoma
A Soluble Form of the Giant Cadherin Fat1 Is Released from Pancreatic Cancer Cells by ADAM10 Mediated Ectodomain Shedding.
Adenocarcinoma
Alternative pathway for the role of furin in tumor cell invasion process. Enhanced MMP-2 levels through bioactive TGFbeta.
Adenocarcinoma
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Adenocarcinoma
Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
Adenocarcinoma of Lung
Effect of Furin inhibitor on lung adenocarcinoma cell growth and metastasis.
Adenocarcinoma of Lung
FURIN correlated with immune infiltration serves as a potential biomarker in SARS-CoV-2 infection-related lung adenocarcinoma.
Adenocarcinoma of Lung
Structural variations and expression profiles of the SARS-CoV-2 host invasion genes in lung cancer.
Adenoma
Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas.
Alzheimer Disease
A ratiometric electrochemical strategy for sensitive determination of Furin activity based on dual signal amplification and antifouling nanosurfaces.
Alzheimer Disease
Gallic Acid is a Dual ?/?-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
Alzheimer Disease
Genetic regulatory subnetworks and key regulating genes in rat hippocampus perturbed by prenatal malnutrition: implications for major brain disorders.
Alzheimer Disease
Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine.
Alzheimer Disease
The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster.
Alzheimer Disease
The influence of BACE1 on macrophage recruitment and activity in the injured peripheral nerve.
Alzheimer Disease
Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.
Alzheimer Disease
[Generation and characterization of the adult neuron-specific ADAM10 knock-out mice].
Amyloidosis
Gallic Acid is a Dual ?/?-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
Amyloidosis, Familial
Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilization.
Amyloidosis, Familial
Gelsolin domain 2 Ca2+ affinity determines susceptibility to furin proteolysis and familial amyloidosis of finnish type.
Amyloidosis, Familial
Pathological and functional amyloid formation orchestrated by the secretory pathway.
Amyloidosis, Familial
The role of gelsolin domain 3 in familial amyloidosis (Finnish type).
Anemia
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.
Anovulation
Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice.
Anthrax
A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen.
Anthrax
A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types.
Anthrax
Anthrax toxin component, Protective Antigen, protects insects from bacterial infections.
Anthrax
Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.
Anthrax
Both PA63 and PA83 are endocytosed within an anthrax protective antigen mixed heptamer: A putative mechanism to overcome a furin deficiency.
Anthrax
Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin.
Anthrax
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.
Anthrax
Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activity.
Anthrax
Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays.
Anthrax
Imaging specific cell surface protease activity in living cells using reengineered bacterial cytotoxins.
Anthrax
Inhibition of furin/PC-catalyzed surface and intracellular processing by small molecules.
Anthrax
Inter-alpha-inhibitor proteins are endogenous furin inhibitors and provide protection against experimental anthrax intoxication.
Anthrax
Latent cytokines: development of novel cleavage sites and kinetic analysis of their differential sensitivity to MMP-1 and MMP-3.
Anthrax
Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin.
Anthrax
Oligomerization of anthrax toxin protective antigen and binding of lethal factor during endocytic uptake into mammalian cells.
Anthrax
Protection from anthrax toxin-mediated killing of macrophages by the combined effects of furin inhibitors and chloroquine.
Anthrax
Selective and potent furin inhibitors protect cells from anthrax without significant toxicity.
Anthrax
Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin.
Anthrax
Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden.
Anthrax
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.
Anthrax
The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing.
Anthrax
Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin.
Aortic Valve Stenosis
Distinct downregulation of C-type natriuretic peptide system in human aortic valve stenosis.
Arthritis
Furin Expression in Patients With Psoriasis-A Patient Cohort Endangered to SARS-COV2?
Arthritis, Rheumatoid
Increased expression of the proprotein convertase enzyme FURIN in rheumatoid arthritis.
Arthritis, Rheumatoid
Increased FURIN expression in rheumatoid arthritis patients and its anti-inflammatory effect.
Arthritis, Rheumatoid
Inhibition of furin results in increased growth, invasiveness and cytokine production of synoviocytes from patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Proprotein convertase enzyme FURIN is upregulated in primary Sjögren's syndrome.
Asthma
A potential new target for asthma therapy: A Disintegrin and Metalloprotease 10 (ADAM10) involvement in murine experimental asthma.
Asthma
ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma.
Asthma
Correction to: Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma.
Astrocytoma
Inhibition of furin-mediated processing results in suppression of astrocytoma cell growth and invasiveness.
Atherosclerosis
A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis.
Atherosclerosis
FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice.
Atherosclerosis
Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.
Atherosclerosis
Hepatic overexpression of the prodomain of furin lessens progression of atherosclerosis and reduces vascular remodeling in response to injury.
Atherosclerosis
Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.
Atherosclerosis
Proprotein convertase enzyme FURIN is upregulated in primary Sjögren's syndrome.
Atherosclerosis
Proprotein convertase furin/PCSK3 and atherosclerosis: New insights and potential therapeutic targets.
Atherosclerosis
Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels.
Atherosclerosis
Proprotein convertases in human atherosclerotic plaques: the overexpression of FURIN and its substrate cytokines BAFF and APRIL.
Autoimmune Diseases
Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway.
Autoimmune Diseases
The Plasma Level of Proprotein Convertase FURIN in Patients with Suspected Infection in the Emergency Room: A Prospective Cohort Study.
Autoimmune Diseases
The Role of Proprotein Convertases in the Regulation of the Function of Immune Cells in the Oncoimmune Response.
Autoimmune Hypophysitis
Frequent appearance of autoantibodies against prohormone convertase 1/3 and neuroendocrine protein 7B2 in patients with nonfunctioning pituitary macroadenoma.
Bacterial Infections
Human furin Cys198 imposes dihedral and positional restraints on His194 for optimal Ser386-proton transfer.
Bacterial Infections
Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine.
Bone Resorption
Proprotein convertase furin regulates osteocalcin and bone endocrine function.
Borna Disease
Processing of the Borna disease virus glycoprotein gp94 by the subtilisin-like endoprotease furin.
Brain Ischemia
Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA.
Breast Neoplasms
ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties.
Breast Neoplasms
Cancer/testis antigen-Plac1 promotes invasion and metastasis of breast cancer through Furin/NICD/PTEN signaling pathway.
Breast Neoplasms
Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases.
Breast Neoplasms
Elevated expression of proprotein convertases alters breast cancer cell growth in response to estrogen and tamoxifen.
Breast Neoplasms
Fas/FasL-dependent and -independent activation of caspase-8 in doxorubicin-treated human breast cancer MCF-7 cells: ADAM10 down-regulation activates Fas/FasL signaling pathway.
Breast Neoplasms
Furin Prodomain ppFurin Enhances Ca2+ Entry Through Orai and TRPC6 Channels' Activation in Breast Cancer Cells.
Breast Neoplasms
Furin-instructed aggregated gold nanoparticles for re-educating tumor associated macrophages and overcoming breast cancer chemoresistance.
Breast Neoplasms
Identification of ADAM10 as a Major Source of HER2 Ectodomain Sheddase Activity in HER2 Overexpressing Breast Cancer Cells.
Breast Neoplasms
In Vivo Bioluminescence Imaging of Furin Activity in Breast Cancer Cells Using Bioluminogenic Substrates.
Breast Neoplasms
Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis.
Breast Neoplasms
Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation.
Breast Neoplasms
Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines.
Breast Neoplasms
Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer.
Breast Neoplasms
Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer.
Breast Neoplasms
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells.
Breast Neoplasms
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.
Breast Neoplasms
Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor.
Bronchitis
Characterization of cellular furin content as a potential factor determining the susceptibility of cultured human and animal cells to coronavirus infectious bronchitis virus infection.
Bronchitis
Proteolytic activation of the spike protein at a novel RRRR/S motif is implicated in furin-dependent entry, syncytium formation, and infectivity of coronavirus infectious bronchitis virus in cultured cells.
Carcinogenesis
Alternative pathway for the role of furin in tumor cell invasion process. Enhanced MMP-2 levels through bioactive TGFbeta.
Carcinogenesis
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Carcinogenesis
FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs.
Carcinogenesis
Hypoxia enhances cancer cell invasion through relocalization of the proprotein convertase furin from the trans-Golgi network to the cell surface.
Carcinogenesis
Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins.
Carcinogenesis
Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activity.
Carcinogenesis
Limitations of inhibitory activities of polyphenols on furin-mediated substrate processing.
Carcinogenesis
Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer.
Carcinogenesis
Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer.
Carcinogenesis
MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice.
Carcinogenesis
Near-Infrared Fluorescent Furin Probe for Revealing the Role of Furin in Cellular Carcinogenesis and Specific Cancer Imaging.
Carcinogenesis
Sheddase Activity of Tumor Necrosis Factor-{alpha} Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck Cancer.
Carcinogenesis
T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development.
Carcinogenesis
The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells.
Carcinogenesis
The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer.
Carcinogenesis
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.
Carcinogenesis
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.
Carcinogenesis
Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth.
Carcinoid Tumor
Expression of prohormone convertase, PC2, in adrenocorticotropin-producing thymic carcinoid with elevated plasma corticotropin-releasing hormone.
Carcinoid Tumor
Immunohistochemical expressions of prohormone convertase (PC)1/3 and PC2 in carcinoids of various organs.
Carcinoma
A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells.
Carcinoma
A second mutant allele of furin in the processing-incompetent cell line, LoVo. Evidence for involvement of the homo B domain in autocatalytic activation.
Carcinoma
Autocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site.
Carcinoma
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Carcinoma
Correction: Simultaneous Expression of Furin and Vascular Endothelial Growth Factor in Human Oral Tongue Squamous Cell Carcinoma Progression.
Carcinoma
Effect of ultraviolet radiation on the expression of pp38MAPK and furin in human keratinocyte-derived cell lines.
Carcinoma
ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activation.
Carcinoma
Elevated furin expression in aggressive human head and neck tumors and tumor cell lines.
Carcinoma
Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus.
Carcinoma
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Carcinoma
ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis.
Carcinoma
Furin expression in squamous cell carcinomas of the oral cavity and other sites evaluated by tissue microarray technology.
Carcinoma
Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells.
Carcinoma
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin.
Carcinoma
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells.
Carcinoma
Prodomain of the proprotein convertase subtilisin/kexin Furin (ppFurin) protects from tumor progression and metastasis.
Carcinoma
Prohormone convertase and autocrine growth factor mRNAs are coexpressed in small cell lung carcinoma.
Carcinoma
Proteolytic cleavage of glycoprotein B is dispensable for in vitro replication, but required for syncytium formation of pseudorabies virus.
Carcinoma
Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells.
Carcinoma
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.
Carcinoma
Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression.
Carcinoma
Soluble Form of the (Pro)Renin Receptor Generated by Intracellular Cleavage by Furin Is Secreted in Plasma.
Carcinoma
Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation.
Carcinoma
The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.
Carcinoma
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.
Carcinoma
Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth.
Carcinoma
[Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas.]
Carcinoma
[Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix].
Carcinoma, Hepatocellular
Enzymatic inhibition of MICA sheddase ADAM17 by lomofungin in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Furin overexpression suppresses tumor growth and predicts a better postoperative disease-free survival in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth.
Carcinoma, Hepatocellular
Polyphenols with indirect proprotein convertase inhibitory activity.
Carcinoma, Hepatocellular
Suppression of furin by interferon-? and the impact on hepatitis B virus antigen biosynthesis in human hepatocytes.
Carcinoma, Hepatocellular
Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines.
Carcinoma, Non-Small-Cell Lung
Proprotein convertase furin in SARS-CoV-2 and non-small cell lung cancer.
Carcinoma, Renal Cell
ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activation.
Carcinoma, Squamous Cell
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Carcinoma, Squamous Cell
Correction: Simultaneous Expression of Furin and Vascular Endothelial Growth Factor in Human Oral Tongue Squamous Cell Carcinoma Progression.
Carcinoma, Squamous Cell
Effect of ultraviolet radiation on the expression of pp38MAPK and furin in human keratinocyte-derived cell lines.
Carcinoma, Squamous Cell
Elevated furin expression in aggressive human head and neck tumors and tumor cell lines.
Carcinoma, Squamous Cell
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Carcinoma, Squamous Cell
Furin expression in squamous cell carcinomas of the oral cavity and other sites evaluated by tissue microarray technology.
Carcinoma, Squamous Cell
Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells.
Carcinoma, Squamous Cell
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin.
Carcinoma, Squamous Cell
Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells.
Carcinoma, Squamous Cell
Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression.
Carcinoma, Squamous Cell
Structural variations and expression profiles of the SARS-CoV-2 host invasion genes in lung cancer.
Carcinoma, Squamous Cell
Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation.
Carcinoma, Squamous Cell
Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth.
Carcinoma, Squamous Cell
[Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix].
Cardiomyopathies
RNA sequencing analysis and atrial natriuretic Peptide production in patients with dilated and ischemic cardiomyopathy.
Cardiovascular Diseases
Proprotein convertase furin/PCSK3 and atherosclerosis: New insights and potential therapeutic targets.
Chikungunya Fever
Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein.
Cholera
Low-cost production of proinsulin in tobacco and lettuce chloroplasts for injectable or oral delivery of functional insulin and C-peptide.
Cholera
Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice.
Cholera
Receptor-mediated oral delivery of a bioencapsulated green fluorescent protein expressed in transgenic chloroplasts into the mouse circulatory system.
Cholera
The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor.
Choriocarcinoma
The (pro)renin receptor and soluble (pro)renin receptor in choriocarcinoma.
Choriocarcinoma
The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization.
Choriocarcinoma
The proprotein convertase furin is required for trophoblast syncytialization.
Choroidal Neovascularization
A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization.
Coinfection
Production and characterization of simian--human immunodeficiency virus-like particles.
Coinfection
Proparathyroid hormone processing by the proprotein convertase-7: comparison with furin and assessment of modulation of parathyroid convertase messenger ribonucleic acid levels by calcium and 1,25-dihydroxyvitamin D3.
Coinfection
Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediated by the human endoprotease furin.
Colitis
Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway.
Colitis, Ulcerative
Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway.
Colonic Neoplasms
Inactivation of proprotein convertases in T cells inhibits PD-1 expression and creates a favorable immune microenvironment in colorectal cancer.
Colonic Neoplasms
Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses.
Colonic Neoplasms
Single Nucleotide Polymorphism (rs4932178) in the P1 Promoter of FURIN Is Not Prognostic to Colon Cancer.
Colorectal Neoplasms
Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin ?-Sarcin- or RNase T1-Based Immunotoxins.
Colorectal Neoplasms
The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer.
Communicable Diseases
Elongated and Shortened Peptidomimetic Inhibitors of the Proprotein Convertase Furin.
Communicable Diseases
Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases.
Communicable Diseases
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Communicable Diseases
The Plasma Level of Proprotein Convertase FURIN in Patients with Suspected Infection in the Emergency Room: A Prospective Cohort Study.
Coronary Artery Disease
FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease-Associated Genetic Variant and Influences Monocyte Transendothelial Migration.
Coronary Artery Disease
FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice.
Coronary Artery Disease
Platelet Activation and Plasma Levels of Furin Are Associated With Prognosis of Patients With Coronary Artery Disease and COVID-19.
Coronavirus Infections
A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation.
Coronavirus Infections
Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells.
Coronavirus Infections
Whole Genome Analysis and Targeted Drug Discovery Using Computational Methods and High Throughput Screening Tools for Emerged Novel Coronavirus (2019-nCoV).
COVID-19
A bird eye view on cystic fibrosis: An underestimated multifaceted chronic disorder.
COVID-19
A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells.
COVID-19
A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection.
COVID-19
ACE2 and Furin Expressions in Oral Epithelial Cells Possibly Facilitate COVID-19 Infection via Respiratory and Fecal-Oral Routes.
COVID-19
ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19.
COVID-19
ACE2, TMPRSS2, and furin gene expression in the airways of people with asthma-implications for COVID-19.
COVID-19
Assessing COVID-19 susceptibility through analysis of the genetic and epigenetic diversity of ACE2-mediated SARS-CoV-2 entry.
COVID-19
Association between circulating furin levels, obesity and pro-inflammatory markers in children.
COVID-19
Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2-infected patients.
COVID-19
Comparison of clinically approved molecules on SARS-CoV-2 drug target proteins: a molecular docking study.
COVID-19
COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells.
COVID-19
COVID-19 in Smokeless Tobacco Habitués: Increased Susceptibility and Transmission.
COVID-19
Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection.
COVID-19
Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19.
COVID-19
Expression of ACE2, TMPRSS2, and Furin in Mouse Ear Tissue, and the Implications for SARS-CoV-2 Infection.
COVID-19
Expression of angiotensin-converting enzyme 2 and proteases in COVID-19 patients: A potential role of cellular FURIN in the pathogenesis of SARS-CoV-2.
COVID-19
Expression profiles of the SARS-CoV-2 host invasion genes in nasopharyngeal and oropharyngeal swabs of COVID-19 patients.
COVID-19
Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infection.
COVID-19
FURIN correlated with immune infiltration serves as a potential biomarker in SARS-CoV-2 infection-related lung adenocarcinoma.
COVID-19
Furin Expression in Patients With Psoriasis-A Patient Cohort Endangered to SARS-COV2?
COVID-19
Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects.
COVID-19
Genomic Feature Analysis of Betacoronavirus Provides Insights Into SARS and COVID-19 Pandemics.
COVID-19
How Do Enveloped Viruses Exploit the Secretory Proprotein Convertases to Regulate Infectivity and Spread?
COVID-19
Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues.
COVID-19
Increased mortality of COVID-19 infected diabetes patients: role of furin proteases.
COVID-19
Instigators of COVID-19 in Immune Cells are Increased in Tobacco Cigarette Smokers and Electronic Cigarette Vapers Compared to Non-smokers.
COVID-19
Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants.
COVID-19
Multimodal single-cell omics analysis identifies epithelium-immune cell interactions and immune vulnerability associated with sex differences in COVID-19.
COVID-19
Osmotic Adaptation by Na+-Dependent Transporters and ACE2: Correlation with Hemostatic Crisis in COVID-19.
COVID-19
Persistently Increased Systemic ACE2 Activity Is Associated With an Increased Inflammatory Response in Smokers With COVID-19.
COVID-19
Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?
COVID-19
Platelet Activation and Plasma Levels of Furin Are Associated With Prognosis of Patients With Coronary Artery Disease and COVID-19.
COVID-19
Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent Bibliometrics.
COVID-19
Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease.
COVID-19
Single-cell analysis of SARS-CoV-2 receptor ACE2 and spike protein priming expression of proteases in the human heart.
COVID-19
Structure of Furin Protease Binding to SARS-CoV-2 Spike Glycoprotein and Implications for Potential Targets and Virulence.
COVID-19
Synergy of melanin and vitamin-D may play a fundamental role in preventing SARS-CoV-2 infections and halt COVID-19 by inactivating furin protease.
COVID-19
The conundrum of using hyperoxia in COVID-19 treatment strategies: may intermittent therapeutic hyperoxia play a helpful role in the expression of the surface receptors ACE2 and Furin in lung tissue via triggering of HIF-1??
COVID-19
The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2.
COVID-19
The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes.
COVID-19
Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells.
COVID-19
Virus strain from a mild COVID-19 patient in Hangzhou represents a new trend in SARS-CoV-2 evolution potentially related to Furin cleavage site.
COVID-19
[Mechanism of QingfeiPaidu decoction for treatment of COVID-19: analysis based on network pharmacology and molecular docking technology].
Creutzfeldt-Jakob Syndrome
TREM2 expression in the brain and biological fluids in prion diseases.
Cystic Fibrosis
Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A-induced cytotoxicity.
Cystic Fibrosis
SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients.
Dementia
Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia.
Dengue
A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection.
Dengue
Dengue virus capsid anchor modulates the efficiency of polyprotein processing and assembly of viral particles.
Dengue
Differential modulation of prM cleavage, extracellular particle distribution, and virus infectivity by conserved residues at nonfurin consensus positions of the dengue virus pr-M junction.
Dengue
Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication.
Dengue
Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins.
Dengue
Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin.
Dengue
Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates.
Diabetes Mellitus
A case of prohormone convertase deficiency diagnosed with type 2 diabetes.
Diabetes Mellitus
Diagnostic utility of BNP, corin and furin as biomarkers for cardiovascular complications in type 2 diabetes mellitus patients.
Diabetes Mellitus
Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues.
Diabetes Mellitus
Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality.
Diabetes Mellitus
The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes.
Diabetes Mellitus
Topical GDF11 accelerates skin wound healing in both type 1 and 2 diabetic mouse models.
Diabetes Mellitus, Type 2
A case of prohormone convertase deficiency diagnosed with type 2 diabetes.
Diabetes Mellitus, Type 2
Diagnostic utility of BNP, corin and furin as biomarkers for cardiovascular complications in type 2 diabetes mellitus patients.
Diphtheria
A novel recombinant immuno-tBid with a furin site effectively suppresses the growth of HER2-positive osteosarcoma cells in vitro.
Diphtheria
A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen.
Diphtheria
A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts.
Diphtheria
Anti-tumor effects of a recombinant anti-prostate specific membrane antigen immunotoxin against prostate cancer cells.
Diphtheria
Evidence for involvement of furin in cleavage and activation of diphtheria toxin.
Diphtheria
Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activity.
Diphtheria
Limitations of inhibitory activities of polyphenols on furin-mediated substrate processing.
Diphtheria
Pseudomonas exotoxin exhibits increased sensitivity to furin when sequences at the cleavage site are mutated to resemble the arginine-rich loop of diphtheria toxin.
Diphtheria
Recombinant immunoproapoptotic proteins with furin site can translocate and kill HER2-positive cancer cells.
Diphtheria
The effect of direct translocation across endosomes on the cytotoxicity of the recombinant protein e23sFv-Fdt-casp6 to HER2 positive gastric cancer cells.
Dry Eye Syndromes
Proprotein convertase enzyme FURIN is upregulated in primary Sjögren's syndrome.
Ectodermal Dysplasia 1, Anhidrotic
Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasia.
Encephalitis
Gallic Acid is a Dual ?/?-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
Encephalitis
The furin-S2' site in avian coronavirus plays a key role in central nervous system damage progression.
Encephalitis, Tick-Borne
Resuscitating mutations in a furin cleavage-deficient mutant of the flavivirus tick-borne encephalitis virus.
Encephalomyelitis, Venezuelan Equine
Antibody to the E3 Glycoprotein Protects Mice Against Lethal Venezuelan Equine Encephalitis.
Endometrial Neoplasms
Proprotein convertases in post-menopausal endometrial cancer: Distinctive regulation and non-invasive diagnosis.
Endometrial Neoplasms
The significance of post-translational removal of ?-DG-N in early stage endometrial cancer development.
Endometriosis
ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling.
Epilepsy
Implications of the subtilisin/kexin-like precursor convertases in the development and function of nervous tissues.
Essential Hypertension
Associations between genetic variations in the FURIN gene and hypertension.
Exocrine Pancreatic Insufficiency
SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients.
Fetal Growth Retardation
Altered serum soluble furin and prorenin receptor levels in pregnancies with pre-eclampsia and fetal growth restriction.
Foot-and-Mouth Disease
Co-expression of self-cleaved multiple proteins derived from Porcine Reproductive and Respiratory Syndrome Virus by bi-cistronic and tri-cistronic DNA vaccines.
Fraser Syndrome
Establishment of proprotein convertase, furinA knocked-out lines in medaka, Oryzias latipes, and unique form of medaka furin-like prorprotein convertase (mflPC).
Fraser Syndrome
Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes.
furin deficiency
A case of prohormone convertase deficiency diagnosed with type 2 diabetes.
furin deficiency
Both PA63 and PA83 are endocytosed within an anthrax protective antigen mixed heptamer: A putative mechanism to overcome a furin deficiency.
furin deficiency
Deficient serum furin predicts risk of abdominal obesity: findings from a prospective cohort of Chinese adults.
furin deficiency
Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic ? Cells of Mice.
furin deficiency
Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy.
Gastrinoma
Proprotein-Processing Endoprotease Furin and its Substrate Parathyroid Hormone-Related Protein Are Coexpressed in Insulinoma Cells.
Gingivitis
[Comparative clinical results in the treatment of gingivitis catarrhalis chronica with Furin M, applied by a tray for retention of the drug and by mouth rinsing]
Glioblastoma
Inhibition of furin-mediated processing results in suppression of astrocytoma cell growth and invasiveness.
Glioblastoma
Reoxygenation of hypoxic glioblastoma multiforme cells potentiates the killing effect of an interleukin-13-based cytotoxin.
Glioma
?1,6 GlcNAc branches-modified protein tyrosine phosphatase Mu attenuates its tyrosine phosphatase activity and promotes glioma cell migration through PLC?-PKC pathways.
Glioma
Processing of immunosuppressive pro-TGF-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases.
Glucose Intolerance
Proprotein convertase furin regulates osteocalcin and bone endocrine function.
Head and Neck Neoplasms
Increased furin activity enhances the malignant phenotype of human head and neck cancer cells.
Head and Neck Neoplasms
Sheddase Activity of Tumor Necrosis Factor-{alpha} Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck Cancer.
Heart Failure
Differential expression of the pro-natriuretic peptide convertases corin and furin in experimental heart failure and atrial fibrosis.
Heart Failure
Post-transcriptional modification of pro-BNP in heart failure: is glycosylation and circulating furin key for cardiovascular homeostasis?
Heart Failure
Post-translational modifications enhance NT-proBNP and BNP production in acute decompensated heart failure.
Heart Failure
Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites.
Heart Failure
Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease.
Hemochromatosis
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.
Hemophilia A
Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models.
Hemophilia A
Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A.
Hemophilia A
Stable expression of native Coagulation factor VIII using the 2A self-processing sequence and furin cleavage site.
Hemorrhagic Fever, Crimean
Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin.
Hemorrhagic Fever, Ebola
Ebola virus envelope glycoprotein derived peptide in human Furin-bound state: computational studies.
Hemorrhagic Fever, Ebola
Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture.
Hepatitis
Cleavage inhibition of the murine coronavirus spike protein by a furin-like enzyme affects cell-cell but not virus-cell fusion.
Hepatitis B
Characterization of genotype-specific carboxyl-terminal cleavage sites of hepatitis B virus e antigen precursor and identification of furin as the candidate enzyme.
Hepatitis B
Entecavir combined with furin inhibitor simultaneously reduces hepatitis B virus replication and e antigen secretion.
Hepatitis B
Furin mRNA expression in peripheral blood correlates with chronic hepatitis B virus infection.
Hepatitis B
Influence of a single nucleotide polymorphism in the P1 promoter of the furin gene on transcription activity and hepatitis B virus infection.
Hepatitis B
Initiation of duck hepatitis B virus infection requires cleavage by a furin-like protease.
Hepatitis B
Proteolytic processing of the hepatitis B virus e antigen precursor. Cleavage at two furin consensus sequences.
Hepatitis B
Suppression of furin by interferon-? and the impact on hepatitis B virus antigen biosynthesis in human hepatocytes.
Hepatitis B
Therapeutic potential of furin inhibitors for the chronic infection of hepatitis B virus.
Hepatitis B
[Hepatitis B virus-mediated effects on host expression of the proprotein convertase Furin].
Hepatitis B, Chronic
Entecavir combined with furin inhibitor simultaneously reduces hepatitis B virus replication and e antigen secretion.
Hepatitis B, Chronic
Furin mRNA expression in peripheral blood correlates with chronic hepatitis B virus infection.
Hepatitis C
Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-?1: Role of TGF-?1 in HCV replication.
Hereditary Sensory and Autonomic Neuropathies
A third HSAN5 mutation disrupts the nerve growth factor furin cleavage site.
Herpes Zoster
Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice.
Herpes Zoster
Extreme positive selection on a new highly-expressed larval glycoprotein (LGP) gene in Galaxias fishes (Osmeriformes: Galaxiidae).
Herpes Zoster
Mouse zona pellucida glycoproteins mZP2 and mZP3 undergo carboxy-terminal proteolytic processing in growing oocytes.
HIV Infections
Soluble T Cell Immunoglobulin Mucin Domain 3 Is Shed from CD8+ T Cells by the Sheddase ADAM10, Is Increased in Plasma during Untreated HIV Infection, and Correlates with HIV Disease Progression.
Hodgkin Disease
Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells.
Huntington Disease
Decreased hypothalamic prohormone convertase expression in huntington disease patients.
Hypercholesterolemia
[Relationship between genetic variation of furin gene and hypercholesterolemia and hyper-low-density lipoprotein cholesterolemia in Kazakh general population].
Hyperkalemia
How SARS-CoV-2 might affect potassium balance via impairing epithelial sodium channels?
Hypertension
Altered serum soluble furin and prorenin receptor levels in pregnancies with pre-eclampsia and fetal growth restriction.
Hypertension
Association of Rs2071410 on Furin with Transient Ischemic Attack Susceptibility and Prognosis in a Chinese Population.
Hypertension
FURIN variant associations with postexercise hypotension are intensity and race dependent.
Hypertension
Identification of Hub Genes Associated with Hypertension and Their Interaction with miRNA Based on Weighted Gene Coexpression Network Analysis (WGCNA) Analysis.
Hypertension
Serum furin as a biomarker of high blood pressure: findings from a longitudinal study in Chinese adults.
Hypertension
The association between paired basic amino acid cleaving enzyme 4 gene haplotype and diastolic blood pressure.
Hyperthyroidism
Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines.
Hypoglycemia
Defective expression of prohormone convertase 4 and enhanced expression of insulin-like growth factor II by pleural solitary fibrous tumor causing hypoglycemia.
Hypophosphatemia
Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia.
Infections
A fusion-loop antibody enhances the infectious properties of immature flavivirus particles.
Infections
A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro.
Infections
A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection.
Infections
A toggle switch controls the low pH-triggered rearrangement and maturation of the dengue virus envelope proteins.
Infections
Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic parameters using the purified, secreted soluble protease expressed by a recombinant baculovirus.
Infections
ACE2 and Furin Expressions in Oral Epithelial Cells Possibly Facilitate COVID-19 Infection via Respiratory and Fecal-Oral Routes.
Infections
Alpha-Defensin HD5 Inhibits Furin Cleavage of Human Papillomavirus 16 L2 To Block Infection.
Infections
Antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2.
Infections
Bioinformatics prediction of B and T cell epitopes within the spike and nucleocapsid proteins of SARS-CoV2.
Infections
Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong.
Infections
Blockage of Filoviral Glycoprotein Processing by Use of a Protein-Based Inhibitor.
Infections
Bovine respiratory syncytial virus lacking the virokinin or with a mutation in furin cleavage site RA(R/K)R109 induces less pulmonary inflammation without impeding the induction of protective immunity in calves.
Infections
Characterization of cellular furin content as a potential factor determining the susceptibility of cultured human and animal cells to coronavirus infectious bronchitis virus infection.
Infections
Cleavage and serum reactivity of the severe acute respiratory syndrome coronavirus spike protein.
Infections
Cleavage of the HPV16 Minor Capsid Protein L2 during Virion Morphogenesis Ablates the Requirement for Cellular Furin during De Novo Infection.
Infections
Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection.
Infections
Common genetic variation in humans impacts in vitro susceptibility to SARS-CoV-2 infection.
Infections
Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection.
Infections
Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis.
Infections
Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection.
Infections
Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19.
Infections
Expression of angiotensin-converting enzyme 2 and proteases in COVID-19 patients: A potential role of cellular FURIN in the pathogenesis of SARS-CoV-2.
Infections
Functional comparison of SARS-CoV-2 with closely related pangolin and bat coronaviruses.
Infections
Furin Cleavage of L2 during Papillomavirus Infection: Minimal Dependence on Cyclophilins.
Infections
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion.
Infections
Furin Expression in Patients With Psoriasis-A Patient Cohort Endangered to SARS-COV2?
Infections
Furin mRNA expression in peripheral blood correlates with chronic hepatitis B virus infection.
Infections
FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs.
Infections
Heparan sulfate-independent cell binding and infection with furin-precleaved papillomavirus capsids.
Infections
Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein.
Infections
Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues.
Infections
Impact of inhibitors and L2 antibodies upon the infectivity of diverse alpha and beta human papillomavirus types.
Infections
Increased susceptibility of SARS-CoV2 infection on oral cancer patients; cause and effects: An hypothesis.
Infections
Influence of a single nucleotide polymorphism in the P1 promoter of the furin gene on transcription activity and hepatitis B virus infection.
Infections
Initiation of duck hepatitis B virus infection requires cleavage by a furin-like protease.
Infections
Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin.
Infections
Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.
Infections
Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?
Infections
Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection.
Infections
Preparation and properties of a papillomavirus infectious intermediate and its utility for neutralization studies.
Infections
Production of Furin-Cleaved Papillomavirus Pseudovirions and Their Use for In Vitro Neutralization Assays of L1- or L2-Specific Antibodies.
Infections
Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediated by the human endoprotease furin.
Infections
Proteolytic processing of the Cryptosporidium glycoprotein gp40/15 by human furin and by a parasite-derived furin-like protease activity.
Infections
Recombinant Sendai viruses expressing fusion proteins with two furin cleavage sites mimic the syncytial and receptor-independent infection properties of respiratory syncytial virus.
Infections
Saliva: What Dental Practitioners Should Know about the Role of This Biofluid in the Transmission and Diagnostic of SARS-CoV-2.
Infections
Single-cell RNA sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium.
Infections
Suppression of furin by interferon-? and the impact on hepatitis B virus antigen biosynthesis in human hepatocytes.
Infections
Targeted infection of endothelial cells by avian influenza virus A/FPV/Rostock/34 (H7N1) in chicken embryos.
Infections
Tetraspanin CD9 affects HPV16 infection by modulating ADAM17 activity and the ERK signalling pathway.
Infections
The old but new: Can unfractioned heparin and low molecular weight heparins inhibit proteolytic activation and cellular internalization of SARS-CoV2 by inhibition of host cell proteases?
Infections
The Plasma Level of Proprotein Convertase FURIN in Patients with Suspected Infection in the Emergency Room: A Prospective Cohort Study.
Infections
The Proprotein Convertase Subtilisin/Kexin FurinA Regulates Zebrafish Host Response against Mycobacterium marinum.
Infections
The role of NH4Cl and cysteine proteases in Human Papillomavirus type 16 infection.
Infections
Therapeutic potential of furin inhibitors for the chronic infection of hepatitis B virus.
Infections
Vimentin Modulates Infectious Internalization of Human Papillomavirus 16 Pseudovirions.
Infections
[Hepatitis B virus-mediated effects on host expression of the proprotein convertase Furin].
Infections
[Study on a putative, proprotein convertase-cleaved product of HBV core protein in vitro].
Infertility
Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice.
Infertility, Female
Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice.
Inflammatory Bowel Diseases
High Expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a Sheddase for TNF-? in the Mucosa of Patients with Inflammatory Bowel Diseases.
Influenza in Birds
Combined QM/MM mechanistic study of the acylation process in furin complexed with the H5N1 avian influenza virus hemagglutinin's cleavage site.
Influenza in Birds
Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza.
Influenza in Birds
Design and Structure-Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin.
Influenza in Birds
Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein.
Influenza in Birds
Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activity.
Influenza in Birds
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.
Influenza in Birds
Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160.
Influenza in Birds
Inhibition of furin/PC-catalyzed surface and intracellular processing by small molecules.
Influenza in Birds
Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation.
Influenza in Birds
Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication.
Influenza in Birds
Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.
Influenza in Birds
Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones.
Influenza in Birds
Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses.
Influenza in Birds
Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure.
Influenza in Birds
Selective and potent furin inhibitors protect cells from anthrax without significant toxicity.
Influenza in Birds
Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus.
Influenza in Birds
Source of high pathogenicity of an avian influenza virus H5N1: why H5 is better cleaved by furin.
Influenza in Birds
Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.
Influenza in Birds
Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin.
Influenza in Birds
[Protease-dependent virus tropism and pathogenicity: The role for TMPRSS2].
Influenza, Human
A mono phenylalanine-based motif (F790) and a leucine-dependent motif (LI760) mediate internalization of furin.
Influenza, Human
A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions.
Influenza, Human
Activation of an influenza virus A/turkey/Oregon/71 HA insertion variant by the subtilisin-like endoprotease furin.
Influenza, Human
Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong.
Influenza, Human
Design and Structure-Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin.
Influenza, Human
Human microRNA-24 modulates highly pathogenic avian-origin H5N1 influenza A virus infection in A549 cells by targeting secretory pathway furin.
Influenza, Human
Identification and characterization of spodoptera frugiperda furin: a thermostable subtilisin-like endopeptidase.
Influenza, Human
Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides.
Influenza, Human
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.
Influenza, Human
Maturation of HIV envelope glycoprotein precursors by cellular endoproteases.
Influenza, Human
Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin.
Influenza, Human
Synthesis of tight binding inhibitors and their action on the proprotein-processing enzyme furin.
Influenza, Human
The H5N1 influenza variant Fujian-like hemagglutinin selected following vaccination exhibits a compromised furin cleavage : neurological Consequences of highly pathogenic Fujian H5N1 strains.
Influenza, Human
[Protease-dependent virus tropism and pathogenicity: The role for TMPRSS2].
Insulin Resistance
Discovery of a possible role of asprosin in ovarian follicular function.
Insulin Resistance
[Relationship between genetic variation of Furin and insulin resistance in Chinese Kazakh population].
Insulinoma
Biosynthesis of the prohormone convertase PC2 in Chinese hamster ovary cells and in rat insulinoma cells.
Insulinoma
Isolation of two complementary deoxyribonucleic acid clones from a rat insulinoma cell line based on similarities to Kex2 and furin sequences and the specific localization of each transcript to endocrine and neuroendocrine tissues in rats.
Insulinoma
Proprotein-Processing Endoprotease Furin and its Substrate Parathyroid Hormone-Related Protein Are Coexpressed in Insulinoma Cells.
Insulinoma
Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate.
Iron Deficiencies
Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis.
Iron Deficiencies
In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23.
Iron Overload
Effect of iron overload on furin expression in wild-type and ?-thalassemic mice.
Iron Overload
Hemojuvelin Modulates Iron Stress During Acute Kidney Injury: Improved by Furin Inhibitor.
Ischemic Attack, Transient
Association of Rs2071410 on Furin with Transient Ischemic Attack Susceptibility and Prognosis in a Chinese Population.
Kidney Neoplasms
The significance of TRIP11 and T3 signalling pathway in renal cancer progression and survival of patients.
Kidney Neoplasms
The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.
Laryngeal Neoplasms
Radiotherapy-associated Furin Expression and Tumor Invasiveness in Recurrent Laryngeal Cancer.
Leukemia
A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection?
Leukemia
Aberrant expression of functional BAFF-system receptors by malignant B-cell precursors impacts leukemia cell survival.
Leukemia
Artificially controlled aggregation of proteins and targeting in hematopoietic cells.
Leukemia
Furin cleavage of the Moloney murine leukemia virus Env precursor reorganizes the spike structure.
Leukemia
Furin cleavage potentiates the membrane fusion-controlling intersubunit disulfide bond isomerization activity of leukemia virus Env.
Leukemia
The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system.
Liver Neoplasms
Furin overexpression suppresses tumor growth and predicts a better postoperative disease-free survival in hepatocellular carcinoma.
Lung Neoplasms
A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection?
Lung Neoplasms
Elevated furin expression in aggressive human head and neck tumors and tumor cell lines.
Lung Neoplasms
Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19.
Lung Neoplasms
Prohormone convertase and autocrine growth factor mRNAs are coexpressed in small cell lung carcinoma.
Lung Neoplasms
Proprotein convertases: "master switches" in the regulation of tumor growth and progression.
Lupus Erythematosus, Systemic
Proprotein convertase enzyme FURIN is upregulated in primary Sjögren's syndrome.
Malaria
Immunization against a merozoite sheddase promotes multiple invasion of red blood cells and attenuates Plasmodium infection in mice.
Malaria
Molecular Determinants for Subcellular Trafficking of the Malarial Sheddase PfSUB2.
Malaria
The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion.
Malaria, Falciparum
Molecular Determinants for Subcellular Trafficking of the Malarial Sheddase PfSUB2.
Malnutrition
Genetic regulatory subnetworks and key regulating genes in rat hippocampus perturbed by prenatal malnutrition: implications for major brain disorders.
Marfan Syndrome
Establishment of proprotein convertase, furinA knocked-out lines in medaka, Oryzias latipes, and unique form of medaka furin-like prorprotein convertase (mflPC).
Massive Hepatic Necrosis
Influences on hepatitis B virus replication by a naturally occurring mutation in the core gene.
Measles
Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein.
Measles
Recombinant measles virus requiring an exogenous protease for activation of infectivity.
Melanoma
Cumulative influence of matrix metalloproteinase-1 and -2 in the migration of melanoma cells within three-dimensional type I collagen lattices.
Melanoma
Furin Prodomain ppFurin Enhances Ca2+ Entry Through Orai and TRPC6 Channels' Activation in Breast Cancer Cells.
Melanoma
Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix Metalloproteinase.
Melanoma
Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma.
Metabolic Syndrome
A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection.
Metabolic Syndrome
ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-?.
Metabolic Syndrome
Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis.
Mouth Neoplasms
Increased susceptibility of SARS-CoV2 infection on oral cancer patients; cause and effects: An hypothesis.
Mouth Neoplasms
Oral cancer and periodontal disease increase the risk of COVID 19? A mechanism mediated through furin and cathepsin overexpression.
Multiple Sclerosis
ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain.
Muscular Dystrophy, Duchenne
Mitochondrial dysfunction causes Ca2+ overload and ECM degradation-mediated muscle damage in C. elegans.
Myocardial Infarction
Co-elevation of brain natriuretic peptide and proprotein-processing endoprotease furin after myocardial infarction in rats.
Myocardial Infarction
Elevated FURIN levels in predicting mortality and cardiovascular events in patients with acute myocardial infarction.
Myocardial Infarction
Role of miR-24, Furin, and Transforming Growth Factor-?1 Signal Pathway in Fibrosis After Cardiac Infarction.
Neoplasm Metastasis
A SEMA3E mutant resistant to cleavage by furins (UNCL-SEMA3E) inhibits choroidal neovascularization.
Neoplasm Metastasis
Cancer/testis antigen-Plac1 promotes invasion and metastasis of breast cancer through Furin/NICD/PTEN signaling pathway.
Neoplasm Metastasis
Effect of Furin inhibitor on lung adenocarcinoma cell growth and metastasis.
Neoplasm Metastasis
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Neoplasm Metastasis
ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis.
Neoplasm Metastasis
Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells via Hippo-YAP pathway.
Neoplasm Metastasis
FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs.
Neoplasm Metastasis
Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.
Neoplasm Metastasis
Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis.
Neoplasm Metastasis
Inhibition of furin/PC-catalyzed surface and intracellular processing by small molecules.
Neoplasm Metastasis
Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer.
Neoplasm Metastasis
Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer.
Neoplasm Metastasis
Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.
Neoplasm Metastasis
Prodomain of the proprotein convertase subtilisin/kexin Furin (ppFurin) protects from tumor progression and metastasis.
Neoplasm Metastasis
Role of c-Src activity in the regulation of gastric cancer cell migration.
Neoplasm Metastasis
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.
Neoplasm Metastasis
Single Nucleotide Polymorphism (rs4932178) in the P1 Promoter of FURIN Is Not Prognostic to Colon Cancer.
Neoplasm Metastasis
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.
Neoplasm Metastasis
The mechanism of PDX in regulating cervical cancer HeLa cell proliferation and tumor formation.
Neoplasm Metastasis
The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion.
Neoplasm Metastasis
Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines.
Neoplasm Metastasis
[Effects of ?1-PDX, a furin inhibitor, on growth, invasion, and tumorigenicity of cervical cancer HeLa cells].
Neoplasms
A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen.
Neoplasms
A fine-needle aspiration-based protein signature discriminates benign from malignant breast lesions.
Neoplasms
A Golgi-Targeting and Dual-Color "Turn-On" Probe for Spatially Precise Imaging of Furin.
Neoplasms
A Novel TNF-? Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice.
Neoplasms
A pressor dose of angiotensin II has no influence on the angiotensin-converting enzyme 2 and other molecules associated with SARS-CoV-2 infection in mice.
Neoplasms
A SEMA3E mutant resistant to cleavage by furins (UNCL-SEMA3E) inhibits choroidal neovascularization.
Neoplasms
Activatable oligomerizable imaging agents for photoacoustic imaging of furin-like activity in living subjects.
Neoplasms
ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding.
Neoplasms
ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice.
Neoplasms
ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells.
Neoplasms
ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-?.
Neoplasms
Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios.
Neoplasms
Alternative pathway for the role of furin in tumor cell invasion process. Enhanced MMP-2 levels through bioactive TGFbeta.
Neoplasms
An Antibody Designed to Improve Adoptive NK-Cell Therapy Inhibits Pancreatic Cancer Progression in a Murine Model.
Neoplasms
Assessing experimental models in myocardial injury: Lack of activation of the proteases TACE and calpain in brief ischaemia and reperfusion.
Neoplasms
BacMam production and crystal structure of nonglycosylated apo human furin at 1.89?Å resolution.
Neoplasms
Blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain.
Neoplasms
Cancer/testis antigen-Plac1 promotes invasion and metastasis of breast cancer through Furin/NICD/PTEN signaling pathway.
Neoplasms
Case Report: Immune-mediated Complete Response in a Patient With Recurrent Advanced Ewing Sarcoma (EWS) After Vigil Immunotherapy.
Neoplasms
Cellular sheddases are induced by Merkel cell polyomavirus small tumour antigen to mediate cell dissociation and invasiveness.
Neoplasms
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Neoplasms
Construction and characterization of novel, recombinant immunotoxins targeting the Her2/neu oncogene product: in vitro and in vivo studies.
Neoplasms
Control of spontaneous ovarian tumors by CD8+ T cells through NKG2D-targeted delivery of antigenic peptide.
Neoplasms
Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents.
Neoplasms
Cytotoxic activity of immunotoxin SS1P is modulated by TACE-dependent mesothelin shedding.
Neoplasms
Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase.
Neoplasms
Defective expression of prohormone convertase 4 and enhanced expression of insulin-like growth factor II by pleural solitary fibrous tumor causing hypoglycemia.
Neoplasms
Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis.
Neoplasms
Detection of a soluble form of CD109 in serum of CD109 transgenic and tumor xenografted mice.
Neoplasms
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
Neoplasms
Distribution and colocalization of cholecystokinin with the prohormone convertase enzymes PC1, PC2, and PC5 in rat brain.
Neoplasms
ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activation.
Neoplasms
Elevated furin expression in aggressive human head and neck tumors and tumor cell lines.
Neoplasms
Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation.
Neoplasms
Endoproteolytic processing of proopiomelanocortin and prohormone convertases 1 and 2 in neuroendocrine cells overexpressing prohormone convertases 1 or 2.
Neoplasms
Engineering of ?1-antitrypsin variants with improved specificity for the proprotein convertase furin using site-directed random mutagenesis.
Neoplasms
Engineering of alpha1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: importance of the P2' residue in stable complex formation of the serpin with proprotein convertase.
Neoplasms
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Neoplasms
Enzyme-instructed self-aggregation of Fe3O4 nanoparticles for enhanced MRI T2 imaging and photothermal therapy of tumors.
Neoplasms
Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19.
Neoplasms
Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation.
Neoplasms
ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis.
Neoplasms
Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP/MMP-17 expression in vivo using beta-galactosidase.
Neoplasms
Expression of angiotensin-converting enzyme 2 and proteases in COVID-19 patients: A potential role of cellular FURIN in the pathogenesis of SARS-CoV-2.
Neoplasms
Expression of microRNA-21 and TIMP-3 in paradoxical psoriasiform reactions during treatment with antitumor necrosis factor agents.
Neoplasms
Expression of the prohormone convertase PC2 correlates with the presence of corticotropin-like intermediate lobe peptide in human adrenocorticotropin-secreting tumors.
Neoplasms
Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis.
Neoplasms
Functionally confirmed compound heterozygous ADAM17 missense loss-of-function variants cause neonatal inflammatory skin and bowel disease 1.
Neoplasms
FURIN correlated with immune infiltration serves as a potential biomarker in SARS-CoV-2 infection-related lung adenocarcinoma.
Neoplasms
Furin Enzyme and pH Synergistically Triggered Aggregation of Gold Nanoparticles for Activated Photoacoustic Imaging and Photothermal Therapy of Tumors.
Neoplasms
Furin expression in squamous cell carcinomas of the oral cavity and other sites evaluated by tissue microarray technology.
Neoplasms
Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells.
Neoplasms
Furin inhibitor D6R suppresses epithelial-mesenchymal transition in SW1990 and PaTu8988 cells via the Hippo-YAP signaling pathway.
Neoplasms
Furin mediates brain-derived neurotrophic factor upregulation in cultured rat astrocytes exposed to oxygen-glucose deprivation.
Neoplasms
Furin overexpression suppresses tumor growth and predicts a better postoperative disease-free survival in hepatocellular carcinoma.
Neoplasms
Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells via Hippo-YAP pathway.
Neoplasms
Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP.
Neoplasms
FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs.
Neoplasms
Gemogenovatucel-T (Vigil) immunotherapy as maintenance in frontline stage III/IV ovarian cancer (VITAL): a randomised, double-blind, placebo-controlled, phase 2b trial.
Neoplasms
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin.
Neoplasms
Human furin Cys198 imposes dihedral and positional restraints on His194 for optimal Ser386-proton transfer.
Neoplasms
Hypoxia enhances cancer cell invasion through relocalization of the proprotein convertase furin from the trans-Golgi network to the cell surface.
Neoplasms
Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays.
Neoplasms
Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues.
Neoplasms
Immunohistochemical expressions of prohormone convertase (PC)1/3 and PC2 in carcinoids of various organs.
Neoplasms
Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.
Neoplasms
In situ evidence of involvement of Schwann cells in ulcerative colitis: autocrine and paracrine signaling by A disintegrin and metalloprotease-17-mediated tumor necrosis factor alpha production.
Neoplasms
In Situ Imaging of Furin Activity with a Highly Stable Probe by Releasing of Precipitating Fluorochrome.
Neoplasms
In Vivo Bioluminescence Imaging of Furin Activity in Breast Cancer Cells Using Bioluminogenic Substrates.
Neoplasms
Inactivation of proprotein convertases in T cells inhibits PD-1 expression and creates a favorable immune microenvironment in colorectal cancer.
Neoplasms
Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin ?-Sarcin- or RNase T1-Based Immunotoxins.
Neoplasms
Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer.
Neoplasms
Increased furin activity enhances the malignant phenotype of human head and neck cancer cells.
Neoplasms
Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis.
Neoplasms
Inhibition of furin results in increased growth, invasiveness and cytokine production of synoviocytes from patients with rheumatoid arthritis.
Neoplasms
Inhibition of furin/PC-catalyzed surface and intracellular processing by small molecules.
Neoplasms
Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor.
Neoplasms
Inhibition of processing of parathyroid hormone-related peptide by anti-sense furin: effect in vitro and in vivo on rat Leydig (H-500) tumor cells.
Neoplasms
Inhibition of Tumor Cells Proliferation and Migration by the Flavonoid Furin Inhibitor Isolated From Oroxylum indicum.
Neoplasms
Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats.
Neoplasms
Interleukin-33 is a Novel Immunosuppressor that Protects Cancer Cells from TIL Killing by a Macrophage-Mediated Shedding Mechanism.
Neoplasms
Intracellular Disassembly of Self-Quenched Nanoparticles Turns NIR Fluorescence on for Sensing Furin Activity in Cells and in Tumors.
Neoplasms
L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas.
Neoplasms
Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines.
Neoplasms
Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth.
Neoplasms
Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer.
Neoplasms
Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer.
Neoplasms
Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis.
Neoplasms
Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site.
Neoplasms
Modifying the soil to affect the seed: role of stromal-derived matrix metalloproteinases in cancer progression.
Neoplasms
Modular Pore-Forming Immunotoxins with Caged Cytotoxicity Tailored by Directed Evolution.
Neoplasms
Near-Infrared Fluorescent Furin Probe for Revealing the Role of Furin in Cellular Carcinogenesis and Specific Cancer Imaging.
Neoplasms
Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix Metalloproteinase.
Neoplasms
One-step 18F-fluorination of smart positron emission tomography tracer for sensing furin activity in tumors.
Neoplasms
p38 Kinase is Crucial for Osteopontin-induced Furin Expression that Supports Cervical Cancer Progression.
Neoplasms
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression.
Neoplasms
Pan-Cancer Analysis of FURIN as a Potential Prognostic and Immunological Biomarker.
Neoplasms
Phase II study of Vigil® DNA engineered immunotherapy as maintenance in advanced stage ovarian cancer.
Neoplasms
Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality.
Neoplasms
Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression.
Neoplasms
Post-translational processing of proopiomelanocortin (POMC) in mouse pituitary melanotroph tumors induced by a POMC-simian virus 40 large T antigen transgene.
Neoplasms
Potent inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin: Implications for broad anti-tumor efficacy.
Neoplasms
Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.
Neoplasms
Processing of CD109 by furin and its role in the regulation of TGF-beta signaling.
Neoplasms
Prodomain of the proprotein convertase subtilisin/kexin Furin (ppFurin) protects from tumor progression and metastasis.
Neoplasms
Proprotein convertases in post-menopausal endometrial cancer: Distinctive regulation and non-invasive diagnosis.
Neoplasms
Proprotein-Processing Endoprotease Furin and its Substrate Parathyroid Hormone-Related Protein Are Coexpressed in Insulinoma Cells.
Neoplasms
Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A.
Neoplasms
Proteolytic processing of pro-opiomelanocortin occurs in acidifying secretory granules of AtT-20 cells.
Neoplasms
Radiotherapy-associated Furin Expression and Tumor Invasiveness in Recurrent Laryngeal Cancer.
Neoplasms
Reactive oxygen species mediate tumor necrosis factor alpha-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate.
Neoplasms
Recombinant immunoproapoptotic proteins with furin site can translocate and kill HER2-positive cancer cells.
Neoplasms
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.
Neoplasms
Relationships between serum HER2 ECD, TIMP-1 and clinical outcomes in Taiwanese breast cancer.
Neoplasms
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.
Neoplasms
Selective cytotoxicity to HER2-positive tumor cells by a recombinant e23sFv-TD-tBID protein containing a furin cleavage sequence.
Neoplasms
Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency.
Neoplasms
Self-Assembly of Amphiphilic Peptides for Recognizing High Furin-Expressing Cancer Cells.
Neoplasms
Sheddase Activity of Tumor Necrosis Factor-{alpha} Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck Cancer.
Neoplasms
Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression.
Neoplasms
Single Nucleotide Polymorphism (rs4932178) in the P1 Promoter of FURIN Is Not Prognostic to Colon Cancer.
Neoplasms
Soluble Form of the (Pro)Renin Receptor Generated by Intracellular Cleavage by Furin Is Secreted in Plasma.
Neoplasms
Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity.
Neoplasms
Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor.
Neoplasms
T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development.
Neoplasms
Targeted Coating With Antigenic Peptide Renders Tumor Cells Susceptible to CD8(+) T Cell-mediated Killing.
Neoplasms
Targeted delivery of activatable fluorescent probe for detection of furin activity in living cells.
Neoplasms
Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype.
Neoplasms
Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin.
Neoplasms
Targeting proprotein convertases in furin-rich lung cancer cells results in decreased in vitro and in vivo growth.
Neoplasms
Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden.
Neoplasms
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.
Neoplasms
The growth hormone receptor interacts with its sheddase, the tumour necrosis factor-alpha-converting enzyme (TACE).
Neoplasms
The mechanism of PDX in regulating cervical cancer HeLa cell proliferation and tumor formation.
Neoplasms
The membrane-proximal domain of ADAM17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase.
Neoplasms
The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion.
Neoplasms
The proprotein convertase furin is required to maintain viability of alveolar rhabdomyosarcoma cells.
Neoplasms
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.
Neoplasms
The Proprotein Convertase Subtilisin/Kexin FurinA Regulates Zebrafish Host Response against Mycobacterium marinum.
Neoplasms
The proprotein convertases furin and PACE4 play a significant role in tumor progression.
Neoplasms
Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines.
Neoplasms
TNF-alpha converting enzyme (TACE) protein expression in different clinical subtypes of multiple sclerosis.
Neoplasms
TNF?-Erk1/2 signaling pathway-regulated SerpinE1 and SerpinB2 are involved in lipopolysaccharide-induced porcine granulosa cell proliferation.
Neoplasms
Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression.
Neoplasms
Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth.
Neoplasms
Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin.
Neoplasms
Tumor imaging using radiolabelled matrix metalloproteinase-activated anthrax proteins.
Neoplasms
Tumor Necrosis Factor-? Converting Enzyme (TACE) Is a Growth Hormone Binding Protein (GHBP) Sheddase: The Metalloprotease TACE/ADAM-17 Is Critical for (PMA-Induced) GH Receptor Proteolysis and GHBP Generation.
Neoplasms
Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation.
Neoplasms
Tumor necrosis factor-alpha converting enzyme in the human placenta throughout gestation.
Neoplasms
Tumor necrosis factor-alpha processing inhibitor-1 inhibits skin fibrosis in a bleomycin-induced murine model of scleroderma.
Neoplasms
Tumour necrosis factor (TNF-alpha) alpha converting enzyme and soluble TNF-alpha receptor type 1 in psoriasis patients in relation to the chronic alcohol consumption.
Neoplasms
[Generation and characterization of the adult neuron-specific ADAM10 knock-out mice].
Neoplasms
[Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix].
Nervous System Diseases
FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs.
Neuralgia
Effect of recombinant adenovirus coding for endomorphin-2 on neuropathic pain in rats.
Neurodegenerative Diseases
Furin promotes dendritic morphogenesis and learning and memory in transgenic mice.
Neurodegenerative Diseases
Roles of endoproteolytic ?-cleavage and shedding of the prion protein in neurodegeneration.
Neurodegenerative Diseases
[Furin as proprotein convertase and its role in normaland pathological biological processes].
Neuroinflammatory Diseases
Gallic Acid is a Dual ?/?-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
Neuroinflammatory Diseases
HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin.
Newcastle Disease
Cellular CARD11 Inhibits the Fusogenic Activity of Newcastle Disease Virus via CBM Signalosome-Mediated Furin Reduction in Chicken Fibroblasts.
Non-alcoholic Fatty Liver Disease
A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection?
Non-alcoholic Fatty Liver Disease
Pediatric Non-Alcoholic Fatty Liver Disease Is Affected by Genetic Variants Involved in Lifespan/Healthspan.
Obesity
A higher level of serum furin indicates a higher risk of microalbuminuria: results from a longitudinal study in Chinese adults.
Obesity
Association between circulating furin levels, obesity and pro-inflammatory markers in children.
Obesity
Deficient serum furin predicts risk of abdominal obesity: findings from a prospective cohort of Chinese adults.
Obesity
Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.
Obesity
Idiopathic gonadotrophin deficiency: genetic questions addressed through phenotypic characterization.
Obesity
Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity.
Obesity
Proprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity.
Obesity
[Association between sequence variation of Furin gene and obesity in ethnic Kazakh from Xinjiang].
Obesity, Abdominal
Deficient serum furin predicts risk of abdominal obesity: findings from a prospective cohort of Chinese adults.
Osteoarthritis
Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGF?-dependent manner and limits osteoarthritis in mice.
Osteoporosis
Association between circulating furin levels, obesity and pro-inflammatory markers in children.
Osteosarcoma
A furin inhibitor downregulates osteosarcoma cell migration by downregulating the expression levels of MT1-MMP via the Wnt signaling pathway.
Osteosarcoma
A novel recombinant immuno-tBid with a furin site effectively suppresses the growth of HER2-positive osteosarcoma cells in vitro.
Ovarian Neoplasms
ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis.
Ovarian Neoplasms
Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer.
Ovarian Neoplasms
Novel cooperative pathway of c-Myc and Furin, a pro-protein convertase, in cell proliferation as a therapeutic target in ovarian cancers.
Overweight
Association between circulating furin levels, obesity and pro-inflammatory markers in children.
Pancreatic Neoplasms
A Soluble Form of the Giant Cadherin Fat1 Is Released from Pancreatic Cancer Cells by ADAM10 Mediated Ectodomain Shedding.
Pancreatic Neoplasms
An Antibody Designed to Improve Adoptive NK-Cell Therapy Inhibits Pancreatic Cancer Progression in a Murine Model.
Pancreatic Neoplasms
Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells via Hippo-YAP pathway.
Pancreatic Neoplasms
Methyl-CpG-binding protein 2 drives the Furin/TGF-?1/Smad axis to promote epithelial-mesenchymal transition in pancreatic cancer cells.
Pancreatic Neoplasms
The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells.
Pancreatic Neoplasms
The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells.
Papillomavirus Infections
Alcohol metabolism by oral streptococci and interaction with human papillomavirus leads to malignant transformation of oral keratinocytes.
Papillomavirus Infections
Furin Cleavage of L2 during Papillomavirus Infection: Minimal Dependence on Cyclophilins.
Papillomavirus Infections
Heparan sulfate-independent cell binding and infection with furin-precleaved papillomavirus capsids.
Paralysis
Mitochondrial dysfunction causes Ca2+ overload and ECM degradation-mediated muscle damage in C. elegans.
Paramyxoviridae Infections
A monomeric uncleaved respiratory syncytial virus F antigen retains prefusion-specific neutralizing epitopes.
Paramyxoviridae Infections
Analysis of cathepsin and furin proteolytic enzymes involved in viral fusion protein activation in cells of the bat reservoir host.
Paramyxoviridae Infections
Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones.
Paramyxoviridae Infections
Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2.
Pemphigus
Pathogenic Epitopes of Autoantibodies in Pemphigus Reside in the Amino-Terminal Adhesive Region of Desmogleins Which Are Unmasked by Proteolytic Processing of Prosequence.
Perinatal Death
Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development.
Periodontal Diseases
Oral cancer and periodontal disease increase the risk of COVID 19? A mechanism mediated through furin and cathepsin overexpression.
Persistent Infection
Furin mRNA expression in peripheral blood correlates with chronic hepatitis B virus infection.
Persistent Infection
The Proprotein Convertase Subtilisin/Kexin FurinA Regulates Zebrafish Host Response against Mycobacterium marinum.
Persistent Infection
Therapeutic potential of furin inhibitors for the chronic infection of hepatitis B virus.
Pheochromocytoma
Differential expression and processing of secretogranin II in relation to the status of pheochromocytoma: implications for the production of the tumoral marker EM66.
Pheochromocytoma
PC5-A-mediated processing of pro-neurotensin in early compartments of the regulated secretory pathway of PC5-transfected PC12 cells.
Pheochromocytoma
Regulation of carboxypeptidase E by membrane depolarization in PC12 pheochromocytoma cells: comparison with mRNAs encoding other peptide- and catecholamine-biosynthetic enzymes.
Pituitary Diseases
Frequent appearance of autoantibodies against prohormone convertase 1/3 and neuroendocrine protein 7B2 in patients with nonfunctioning pituitary macroadenoma.
Pituitary Neoplasms
Distribution and regulation of proconvertases PC1 and PC2 in human pituitary adenomas.
Pituitary Neoplasms
Frequent appearance of autoantibodies against prohormone convertase 1/3 and neuroendocrine protein 7B2 in patients with nonfunctioning pituitary macroadenoma.
Pneumonia
Bovine respiratory syncytial virus lacking the virokinin or with a mutation in furin cleavage site RA(R/K)R109 induces less pulmonary inflammation without impeding the induction of protective immunity in calves.
Polycystic Ovary Syndrome
Discovery of a possible role of asprosin in ovarian follicular function.
Post-Exercise Hypotension
FURIN variant associations with postexercise hypotension are intensity and race dependent.
Postural Orthostatic Tachycardia Syndrome
Proconvertase Furin Is Downregulated in Postural Orthostatic Tachycardia Syndrome.
Prader-Willi Syndrome
Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome.
Pre-Eclampsia
Altered serum soluble furin and prorenin receptor levels in pregnancies with pre-eclampsia and fetal growth restriction.
Prostatic Neoplasms
ALCAM/CD166 Is a TGF-?-Responsive Marker and Functional Regulator of Prostate Cancer Metastasis to Bone.
Prostatic Neoplasms
The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.
Proteinuria
The epithelial sodium channel ?-subunit is processed proteolytically in human kidney.
Psoriasis
A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection?
Psoriasis
Expression of microRNA-21 and TIMP-3 in paradoxical psoriasiform reactions during treatment with antitumor necrosis factor agents.
Psoriasis
Furin Expression in Patients With Psoriasis-A Patient Cohort Endangered to SARS-COV2?
Pulmonary Disease, Chronic Obstructive
Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis.
Pulmonary Disease, Chronic Obstructive
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis.
Pulmonary Disease, Chronic Obstructive
Dysbalance of ACE2 levels - a possible cause for severe COVID-19 outcome in COPD.
Pulmonary Edema
Is Spironolactone the Preferred Renin-Angiotensin-Aldosterone Inhibitor for Protection Against COVID-19?
Rhabdomyosarcoma
Furin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse model.
Rhabdomyosarcoma
The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion.
Rhabdomyosarcoma, Alveolar
The proprotein convertase furin is required to maintain viability of alveolar rhabdomyosarcoma cells.
Rheumatic Diseases
The Plasma Level of Proprotein Convertase FURIN in Patients with Suspected Infection in the Emergency Room: A Prospective Cohort Study.
Sarcoma, Ewing
Case Report: Immune-mediated Complete Response in a Patient With Recurrent Advanced Ewing Sarcoma (EWS) After Vigil Immunotherapy.
Seizures
Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA expression of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived neurotrophic factor expression.
Sepsis
Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis.
Sepsis
Separating signal from noise: the challenge of identifying useful biomarkers in sepsis.
Sepsis
The Plasma Level of Proprotein Convertase FURIN in Patients with Suspected Infection in the Emergency Room: A Prospective Cohort Study.
Severe Acute Respiratory Syndrome
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis.
Severe Acute Respiratory Syndrome
Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity.
Severe Acute Respiratory Syndrome
FURIN correlated with immune infiltration serves as a potential biomarker in SARS-CoV-2 infection-related lung adenocarcinoma.
Severe Acute Respiratory Syndrome
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.
Severe Acute Respiratory Syndrome
The SARS-CoV-2 Transcriptome and the Dynamics of the S Gene Furin Cleavage Site in Primary Human Airway Epithelia.
Severe Acute Respiratory Syndrome
The Science Underlying COVID-19: Implications for the Cardiovascular System.
Skin Neoplasms
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Skin Neoplasms
T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development.
Small Cell Lung Carcinoma
Prohormone convertase and autocrine growth factor mRNAs are coexpressed in small cell lung carcinoma.
Solitary Fibrous Tumors
Defective expression of prohormone convertase 4 and enhanced expression of insulin-like growth factor II by pleural solitary fibrous tumor causing hypoglycemia.
Somatostatinoma
Proprotein-Processing Endoprotease Furin and its Substrate Parathyroid Hormone-Related Protein Are Coexpressed in Insulinoma Cells.
Spinal Cord Injuries
Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion.
Squamous Cell Carcinoma of Head and Neck
Correction: Simultaneous Expression of Furin and Vascular Endothelial Growth Factor in Human Oral Tongue Squamous Cell Carcinoma Progression.
Squamous Cell Carcinoma of Head and Neck
Elevated furin expression in aggressive human head and neck tumors and tumor cell lines.
Squamous Cell Carcinoma of Head and Neck
Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells.
Squamous Cell Carcinoma of Head and Neck
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin.
Squamous Cell Carcinoma of Head and Neck
Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression.
Squamous Cell Carcinoma of Head and Neck
Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation.
Squamous Cell Carcinoma of Head and Neck
The proprotein convertase furin in tumour progression.
Stomach Neoplasms
Prohormone convertase furin has a role in gastric cancer cell proliferation with parathyroid hormone-related peptide in a reciprocal manner.
Stomach Neoplasms
Role of c-Src activity in the regulation of gastric cancer cell migration.
Stroke
Serum activity of angiotensin converting enzyme 2 is decreased in patients with acute ischemic stroke.
Tachycardia
Proconvertase Furin Is Downregulated in Postural Orthostatic Tachycardia Syndrome.
Teratocarcinoma
CCK processing by pituitary GH3 cells, human teratocarcinoma cells NT2 and hNT differentiated human neuronal cells evidence for a differentiation-induced change in enzyme expression and pro CCK processing.
Thrombosis
Ibrutinib, but not zanubrutinib, induces platelet receptor shedding of GPIb-IX-V complex and integrin ?IIb?3 in mice and humans.
Thyroid Neoplasms
Differential modulation of prohormone convertase mRNA by second messenger activators in two cholecystokinin-producing cell lines.
Trauma, Nervous System
ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury.
Triple Negative Breast Neoplasms
Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer.
Triple Negative Breast Neoplasms
Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer.
Uterine Cervical Neoplasms
Identification of a Six-Gene Signature for Predicting the Overall Survival of Cervical Cancer Patients.
Uterine Cervical Neoplasms
p38 Kinase is Crucial for Osteopontin-induced Furin Expression that Supports Cervical Cancer Progression.
Uterine Cervical Neoplasms
[Effects of ?1-PDX, a furin inhibitor, on growth, invasion, and tumorigenicity of cervical cancer HeLa cells].
Vaccinia
Activation of an influenza virus A/turkey/Oregon/71 HA insertion variant by the subtilisin-like endoprotease furin.
Vaccinia
Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage.
Vaccinia
Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.
Vaccinia
Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases.
Vaccinia
Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways.
Vaccinia
Comparison of substrate specificities against the fusion glycoprotein of virulent Newcastle disease virus between a chick embryo fibroblast processing protease and mammalian subtilisin-like proteases.
Vaccinia
Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin.
Vaccinia
Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide.
Vaccinia
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.
Vaccinia
Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation.
Vaccinia
Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.
Vaccinia
Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3.
Vaccinia
Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study.
Vaccinia
Proprotein processing activity and cleavage site selectivity of the Kex2-like endoprotease PACE4.
Vaccinia
Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses.
Vaccinia
Role of prohormone convertases in pro-neuropeptide Y processing: coexpression and in vitro kinetic investigations.
Vaccinia
Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus.
Vaccinia
Stretch-induced hypertrophic growth of cardiocytes and processing of brain-type natriuretic peptide are controlled by proprotein-processing endoprotease furin.
Vaccinia
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity.
Vascular Diseases
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.
Vascular System Injuries
Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels.
Vipoma
Proprotein-Processing Endoprotease Furin and its Substrate Parathyroid Hormone-Related Protein Are Coexpressed in Insulinoma Cells.
Viremia
The furin-S2' site in avian coronavirus plays a key role in central nervous system damage progression.
Virus Diseases
ACE2 expression is related to the interferon response in airway epithelial cells but is that functional for SARS-CoV-2 entry?
Virus Diseases
Characterization of cellular furin content as a potential factor determining the susceptibility of cultured human and animal cells to coronavirus infectious bronchitis virus infection.
Virus Diseases
Design and Structure-Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin.
Virus Diseases
Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol.
Virus Diseases
Human microRNA-24 modulates highly pathogenic avian-origin H5N1 influenza A virus infection in A549 cells by targeting secretory pathway furin.
Virus Diseases
Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays.
Virus Diseases
Template-assisted rational design of peptide inhibitors of furin using the lysine fragment of the mung bean trypsin inhibitor.
Virus Diseases
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.
Virus Diseases
The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes.
Vitiligo
The Ca2+-Binding Capacity of Epidermal Furin Is Disrupted by H2O2-Mediated Oxidation in Vitiligo.
West Nile Fever
The infectivity of prM-containing partially mature West Nile virus does not require the activity of cellular furin-like proteases.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
additional information
additional information
no PCSK3 in head, ovary, and small intestine, expression in the adult, not embryo stage
brenda
additional information
-
no PCSK3 in head, ovary, and small intestine, expression in the adult, not embryo stage
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination of neuropeptides and expression profiling, overview
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Delfino, K.R.; Southey, B.R.; Sweedler, J.V.; Rodriguez-Zas, S.L.
Genome-wide census and expression profiling of chicken neuropeptide and prohormone convertase genes
Neuropeptides
44
31-44
2010
Gallus gallus (Q91000), Gallus gallus
brenda
EXTERNAL LINKS (specific for EC-Number 3.4.21.75)
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
About BRENDA
Social media
Help
Survey
Download
Contribution
Legal
Curated at
Member of
