Reference on EC 3.4.21.61 - Kexin
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Steiner, D.F.; Smeekens, S.P.; Ohagi, S.; Chan, S.J.
The new enzymology of precursor processing endoproteases
J. Biol. Chem.
267
23435-23438
1992
Saccharomyces cerevisiae
Fuller, R.S.; Brake, A.; Thorner, J.
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease
Proc. Natl. Acad. Sci. USA
86
1434-1438
1989
Saccharomyces cerevisiae, Saccharomyces cerevisiae overproducing
Achstetter, T.; Wolf, D.H.
Hormone processing and membrane-bound proteinases in yeast
EMBO J.
4
173-177
1985
Saccharomyces cerevisiae
Julius, D.; Brake, A.; Blair, L.; Kunisawa, R.; Thorner, J.
Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor
Cell
37
1075-1089
1984
Saccharomyces cerevisiae
Mizuno, K.; Nakamura, T.; Oshima, T.; Tanaka, S.; Matsuo, H.
Characterization of KEX2-encoded endopeptidase from yeast Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
159
305-311
1989
Saccharomyces cerevisiae
Mizuno, K.; Nakamura, T.; Ohshima, T.; Tanaka, S.; Matsuo, H.
Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases
Biochem. Biophys. Res. Commun.
156
246-254
1988
Saccharomyces cerevisiae
Angliker, H.; Wikstrom, P.; Shaw, E.; Brenner, C.; Fuller, R.S.
The synthesis of inhibitors for processing proteinases and their action on the Kex2 proteinase of yeast
Biochem. J.
293
75-81
1993
Saccharomyces cerevisiae
Brenner, C.; Bevan, A.; Fuller, R.S.
Biochemical and genetic methods for analyzing specificity and activity of a precursor-processing enzyme: yeast Kex2 protease, kexin
Methods Enzymol.
244
152-167
1994
Saccharomyces cerevisiae
Rockwell, N.C.; Krysan, D.J.; Fuller, R.S.
Synthesis of Peptidyl Methylcoumarin Esters as Substrates and Active-Site Titrants for the Prohormone Processing Proteases Kex2 and PC2
Anal. Biochem.
280
201-208
2000
Saccharomyces cerevisiae
Rockwell, N.C.; Fuller, R.S.
Interplay between S1 and S4 subsites in Kex2 protease: Kex2 exhibits dual specificity for the P4 side chain
Biochemistry
37
3386-3391
1998
Saccharomyces cerevisiae
Rockwell, N.C.; Fuller, R.S.
Direct measurement of acylenzyme hydrolysis demonstrates rate-limiting deacylation in cleavage of physiological sequences by the processing protease Kex2
Biochemistry
40
3657-3665
2001
Saccharomyces cerevisiae
Holyoak, T.; Wilson, M.A.; Fenn, T.D.; Kettner, C.A.; Petsko, G.A.; Fuller, R.S.; Ringe, D.
2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor
Biochemistry
42
6709-6718
2003
Saccharomyces cerevisiae (P13134)
Bessmertnaya, L.; Loiko, II; Goncharova, T.I.; Ivanov, N.V.; Rumsh, L.D.; Antonov, V.K.
Specific cleavage of hybrid proteins by proteinase encoded by the KEX2 gene
Biochemistry
62
850-857
1997
Saccharomyces cerevisiae
Suzuki, Y.; Ikeda, N.; Kataoka, E.; Ohsuye, K.
Effect of amino acid substitution at the P3 and P4 subsites of fusion proteins on Kex2 protease activity
Biotechnol. Appl. Biochem.
32
53-60
2000
Saccharomyces cerevisiae
-
Liu, Z.X.; Fei, H.; Chi, C.W.
Two engineered eglin c mutants potently and selectively inhibiting kexin or furin
FEBS Lett.
556
116-120
2004
Saccharomyces cerevisiae
Rockwell, N.C.; Fuller, R.S.
Differential utilization of enzyme-substrate interactions for acylation but not deacylation during the catalytic cycle of Kex2 protease
J. Biol. Chem.
276
38394-38399
2001
Saccharomyces cerevisiae
Han, H.E.; Rho, S.H.; Lee, Y.J.; Park, W.J.
Engineering of Kex2 variants exhibiting altered substrate specificity
Biochem. Biophys. Res. Commun.
337
1102-1106
2005
Saccharomyces cerevisiae
Holyoak, T.; Kettner, C.A.; Petsko, G.A.; Fuller, R.S.; Ringe, D.
Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases
Biochemistry
43
2412-2421
2004
Saccharomyces cerevisiae
Waechter, A.; Schwappach, B.
The yeast CLC chloride channel is proteolytically processed by the furin-like protease Kex2p in the first extracellular loop
FEBS Lett.
579
1149-1153
2005
Saccharomyces cerevisiae
Rozan, L.; Krysan, D.J.; Rockwell, N.C.; Fuller, R.S.
Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin
J. Biol. Chem.
279
35656-35663
2004
Saccharomyces cerevisiae
Ugleholdt, R.; Poulsen, M.L.; Holst, P.J.; Irminger, J.C.; Orskov, C.; Pedersen, J.; Rosenkilde, M.M.; Zhu, X.; Steiner, D.F.; Holst, J.J.
Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor
J. Biol. Chem.
281
11050-11057
2006
Mus musculus, Rattus norvegicus
Rabah, N.; Gauthier, D.; Dikeakos, J.D.; Reudelhuber, T.L.; Lazure, C.
The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro
FEBS J.
274
3482-3491
2007
Mus musculus
Mayer, G.; Hamelin, J.; Asselin, M.; Pasquato, A.; Marcinkiewicz, E.; Tang, M.; Tabibzadeh, S.; Seidah, N.G.
The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates
J. Biol. Chem.
283
2373-2384
2008
Homo sapiens
Serviene, E.; Cepononyte, S.; Lebionka, A.; Melvydas, V.
Influence of Kex1p and Kex2p proteases on the function of Saccharomyces cerevisiae K2 preprotoxin
Biologija (Vilnius)
53
35-38
2007
Saccharomyces cerevisiae
-
Heiman, M.G.; Engel, A.; Walter, P.
The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating
J. Cell Biol.
176
209-222
2007
Lachancea kluyveri
Billova, S.; Galanopoulou, A.S.; Seidah, N.G.; Qiu, X.; Kumar, U.
Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain
Neuroscience
147
403-418
2007
Rattus norvegicus
Thacker, C.; Sheps, J.A.; Rose, A.M.
Caenorhabditis elegans dpy-5 is a cuticle procollagen processed by a proprotein convertase
Cell. Mol. Life Sci.
63
1193-1204
2006
Caenorhabditis elegans
Alborn, W.E.; Cao, G.; Careskey, H.E.; Qian, Y.W.; Subramaniam, D.R.; Davies, J.; Conner, E.M.; Konrad, R.J.
Serum proprotein convertase subtilisin kexin type 9 is correlated directly with serum LDL cholesterol
Clin. Chem.
53
1814-1819
2007
Homo sapiens
Schmidt, R.J.; Zhang, Y.; Zhao, Y.; Qian, Y.W.; Wang, H.; Lin, A.; Ehsani, M.E.; Yu, X.; Wang, G.; Singh, J.; Su, E.W.; Li, S.; Konrad, R.J.; Cao, G.
A novel splicing variant of proprotein convertase subtilisin/kexin type 9
DNA Cell Biol.
27
183-189
2008
Homo sapiens
Kobayashi, H.; Takahashi, E.; Oguma, K.; Fujii, Y.; Yamanaka, H.; Negishi, T.; Arimoto-Kobayashi, S.; Tsuji, T.; Okamoto, K.
Cleavage specificity of the serine protease of Aeromonas sobria, a member of the kexin family of subtilases
FEMS Microbiol. Lett.
256
165-170
2006
Aeromonas sobria
Graham, M.J.; Lemonidis, K.M.; Whipple, C.P.; Subramaniam, A.; Monia, B.P.; Crooke, S.T.; Crooke, R.M.
Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice
J. Lipid Res.
48
763-767
2007
Mus musculus, Mus musculus C57BL/6
Careskey, H.E.; Davis, R.A.; Alborn, W.E.; Troutt, J.S.; Cao, G.; Konrad, R.J.
Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9
J. Lipid Res.
49
394-398
2008
Homo sapiens
Jeong, H.J.; Lee, H.S.; Kim, K.S.; Kim, Y.K.; Yoon, D.; Park, S.W.
Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2
J. Lipid Res.
49
399-409
2008
Homo sapiens, Mus musculus
Wheatley, J.L.; Holyoak, T.
Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2
Proc. Natl. Acad. Sci. USA
104
6626-6631
2007
Saccharomyces cerevisiae
Leblond, F.; Seidah, N.G.; Precourt, L.P.; Delvin, E.; Dominguez, M.; Levy, E.
Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells
Am. J. Physiol. Gastrointest. Liver Physiol.
296
G805-G815
2009
Homo sapiens (Q8NBP7)
Le May, C.; Kourimate, S.; Langhi, C.; Chetiveaux, M.; Jarry, A.; Comera, C.; Collet, X.; Kuipers, F.; Krempf, M.; Cariou, B.; Costet, P.
Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia
Arterioscler. Thromb. Vasc. Biol.
29
684-690
2009
Mus musculus, Homo sapiens (Q8NBP7), Homo sapiens
Kourimate, S.; Chetiveaux, M.; Jarnoux, A.L.; Lalanne, F.; Costet, P.
Cellular and secreted pro-protein convertase subtilisin/kexin type 9 catalytic activity in hepatocytes
Atherosclerosis
206
134-140
2009
Homo sapiens (Q8NBP7), Homo sapiens, Mus musculus
Ni, Y.G.; Condra, J.H.; Orsatti, L.; Shen, X.; Di Marco, S.; Pandit, S.; Bottomley, M.J.; Ruggeri, L.; Cummings, R.T.; Cubbon, R.M.; Santoro, J.C.; Ehrhardt, A.; Lewis, D.; Fisher, T.S.; Ha, S.; Njimoluh, L.; Wood, D.D.; Hammond, H.A.; Wisniewski, D.; Volpari, C.; Noto, A.; Lo Surdo, P.; Hubbard, B.; Carfi, A.
A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake
J. Biol. Chem.
285
12882-12891
2010
Homo sapiens (Q8NBP7)
Lan, H.; Pang, L.; Smith, M.M.; Levitan, D.; Ding, W.; Liu, L.; Shan, L.; Shah, V.V.; Laverty, M.; Arreaza, G.; Zhang, Q.; Murgolo, N.J.; Hernandez, M.; Greene, J.R.; Gustafson, E.L.; Bayne, M.L.; Davis, H.R.; Hedrick, J.A.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) affects gene expression pathways beyond cholesterol metabolism in liver cells
J. Cell. Physiol.
224
273-281
2010
Homo sapiens (Q8NBP7)
Chan, J.C.; Piper, D.E.; Cao, Q.; Liu, D.; King, C.; Wang, W.; Tang, J.; Liu, Q.; Higbee, J.; Xia, Z.; Di, Y.; Shetterly, S.; Arimura, Z.; Salomonis, H.; Romanow, W.G.; Thibault, S.T.; Zhang, R.; Cao, P.; Yang, X.P.; Yu, T.; Lu, M.; Retter, M.W.; Kwon, G.; Henne, K.; Pan, O.; Tsai, M.M.; Fuchslocher, B.; Yang, E.; Z, Z.h.
A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
Proc. Natl. Acad. Sci. USA
106
9820-9825
2009
Homo sapiens (Q8NBP7), Macaca fascicularis, Mus musculus
Davignon, J.; Dubuc, G.
Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels
Trans. Am. Clin. Climatol. Assoc.
120
163-173
2009
Homo sapiens (Q8NBP7), Homo sapiens
Mousavi, S.A.; Berge, K.E.; Berg, T.; Leren, T.P.
Affinity and kinetics of proprotein convertase subtilisin/kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells
FEBS J.
278
2938-2950
2011
Homo sapiens
Zandberg, W.F.; Benjannet, S.; Hamelin, J.; Pinto, B.M.; Seidah, N.G.
N-glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1
Glycobiology
21
1290-1300
2011
Mus musculus
Du, F.; Hui, Y.; Zhang, M.; Linton, M.; Fazio, S.; Fan, D.
A novel domain interaction regulates secretion of proprotein convertase subtilisin/kexin type 9
J. Biol. Chem.
286
43054-43061
2011
Homo sapiens, Mus musculus
Pearlstein, R.; Hu, Q.; Zhou, J.; Yowe, D.; Levell, J.; Dale, B.; Kaushik, V.; Daniels, D.; Hanrahan, S.; Sherman, W.; Abel, R.
New hypotheses about the structure-function of proprotein convertase subtilisin/kexin type 9: Analysis of the epidermal growth factor-like repeat A docking site using WaterMap
Proteins
78
2571-2586
2010
Homo sapiens
Sun, H.; Samarghandi, A.; Zhang, N.; Yao, Z.; Xiong, M.; Teng, B.B.
Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor
Arterioscler. Thromb. Vasc. Biol.
32
1585-1595
2012
Homo sapiens (Q8NBP7), Mus musculus (Q80W65), Mus musculus C57BL/6 (Q80W65)
Schulz, R.; Schlueter, K.D.; Laufs, U.
Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9)
Basic Res. Cardiol.
110
4
2015
Mus musculus (Q80W65), Homo sapiens (Q8NBP7)
Kwakernaak, A.J.; Lambert, G.; Dullaart, R.P.
Plasma proprotein convertase subtilisin-kexin type 9 is predominantly related to intermediate density lipoproteins
Clin. Biochem.
47
679-682
2014
Homo sapiens (Q8NBP7)
Lipari, M.T.; Li, W.; Moran, P.; Kong-Beltran, M.; Sai, T.; Lai, J.; Lin, S.J.; Kolumam, G.; Zavala-Solorio, J.; Izrael-Tomasevic, A.; Arnott, D.; Wang, J.; Peterson, A.S.; Kirchhofer, D.
Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels
J. Biol. Chem.
287
43482-43491
2012
Homo sapiens (Q8NBP7)
Chorba, J.S.; Shokat, K.M.
The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis
J. Biol. Chem.
289
29030-29043
2014
Homo sapiens (Q8NBP7)
Canuel, M.; Sun, X.; Asselin, M.C.; Paramithiotis, E.; Prat, A.; Seidah, N.G.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1)
PLoS ONE
8
e64145
2013
Cricetulus griseus, Homo sapiens, Mus musculus (Q80W65), Mus musculus
Geschwindner, S.; Andersson, G.M.; Beisel, H.G.; Breuer, S.; Hallberg, C.; Kihlberg, B.M.; Lindqvist, A.M.; OMahony, G.; Plowright, A.T.; Raubacher, F.; Knecht, W.
Characterisation of de novo mutations in the C-terminal domain of proprotein convertase subtilisin/kexin type 9
Protein Eng. Des. Sel.
2015
1-9
2015
Homo sapiens (Q8NBP7), Homo sapiens
Volpe, M.; Rubattu, S.
Novel insights into the mechanisms regulating pro-atrial natriuretic peptide cleavage in the heart and blood pressure regulation proprotein convertase subtilisin/kexin 6 is the corin activating enzyme
Circ. Res.
118
196-198
2016
Homo sapiens
Bang, S.; Chae, H.S.; Lee, C.; Choi, H.G.; Ryu, J.; Li, W.; Lee, H.; Jeong, G.S.; Chin, Y.W.; Shim, S.H.
New aromatic compounds from the fruiting body of Sparassis crispa (Wulf.) and their inhibitory activities on proprotein convertase subtilisin/kexin type 9 mRNA expression
J. Agric. Food Chem.
65
6152-6157
2017
Homo sapiens (Q8NBP7)
Jiang, H.; Wang, L.; Wang, F.; Pan, J.
Proprotein convertase subtilisin/kexin type 6 promotes in vitro proliferation, migration and inflammatory cytokine secretion of synovial fibroblast-like cells from rheumatoid arthritis via nuclear-kappaB, signal transducer and activator of transcription 3 and activator of transcription 3 and extracellular signal regulated 1/2 pathways
Mol. Med. Rep.
16
8477-8484
2017
Homo sapiens (P29122), Homo sapiens
Wang, P.; Wang, F.; Wang, L.; Pan, J.
Proprotein convertase subtilisin/kexin type 6 activates the extracellular signal-regulated kinase 1/2 and Wnt family member 3A pathways and promotes in vitro proliferation, migration and invasion of breast cancer MDA-MB-231 cells
Oncol. Lett.
16
145-150
2018
Homo sapiens (P29122), Homo sapiens
html completed
